1. [ß-lactam antibiotics resistance in Latin American countries].
- Author
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Latorre-Barragan MF, Zurita-Leal AC, and Gudiño Gomezjurado ME
- Subjects
- Bacterial Infections epidemiology, Bacterial Infections microbiology, Drug Resistance, Bacterial genetics, Gram-Negative Bacteria drug effects, Gram-Negative Bacteria isolation & purification, Gram-Positive Bacteria drug effects, Gram-Positive Bacteria isolation & purification, Humans, Latin America, Anti-Bacterial Agents pharmacology, Bacterial Infections drug therapy, beta-Lactams pharmacology
- Abstract
Ever since antimicrobial activity was observed at the end of the XIX century and antibiotics were produced on a large scale in the 40s, microorganisms have developed multiple resistance mechanisms, making treatment of infectious diseases difficult. For instance, several Gram-positive and Gram-negative bacteria lowered their sensitivity to ß-Lactam antibiotics as a result of their inadequate use and abuse. For this reason, microbial resistance to these drugs represents an increasing health problem in Latin America due to the emergence of drug-resistant bacterial strains. This review aims to summarize and analyze scientific literature reporting resistance to ß-lactam antibiotics in Latin America. We compiled scientific papers published during the last five years from PubMed, SciELO, and LILACS-BIREME. We found that: (i) it is common to identify resistance genes for ß-lactams in the soil and animal farms, and (ii) over 40% of strains isolated from clinical samples developed resistance against ß-lactam antibiotics.
- Published
- 2019
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