Search

Your search keyword '"Latus, Heiner"' showing total 274 results
Start Over Author "Latus, Heiner"
274 results on '"Latus, Heiner"'

2. Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot.

Author

Mîra, Anna, Lamata, Pablo, Pushparajah, Kuberan, Abraham, Georgina, Mauger, Charlène, McCulloch, Andrew, Omens, Jeffrey, Bissell, Malenka, Blair, Zach, Huffaker, Tyler, Tandon, Animesh, Engelhardt, Sandy, Koehler, Sven, Pickardt, Thomas, Beerbaum, Philipp, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Young, Alistair, and Hussain, Tarique

Subjects
Biomarker, Biventricular shape, Magnetic resonance imaging, Tetralogy of Fallot, Cardiac Surgical Procedures, Humans, Predictive Value of Tests, Pulmonary Valve Insufficiency, Tetralogy of Fallot, Ventricular Function, Right
Abstract

BACKGROUND: Maladaptive remodelling mechanisms occur in patients with repaired tetralogy of Fallot (rToF) resulting in a cycle of metabolic and structural changes. Biventricular shape analysis may indicate mechanisms associated with adverse events independent of pulmonary regurgitant volume index (PRVI). We aimed to determine novel remodelling patterns associated with adverse events in patients with rToF using shape and function analysis. METHODS: Biventricular shape and function were studied in 192 patients with rToF (median time from TOF repair to baseline evaluation 13.5 years). Linear discriminant analysis (LDA) and principal component analysis (PCA) were used to identify shape differences between patients with and without adverse events. Adverse events included death, arrhythmias, and cardiac arrest with median follow-up of 10 years. RESULTS: LDA and PCA showed that shape characteristics pertaining to adverse events included a more circular left ventricle (LV) (decreased eccentricity), dilated (increased sphericity) LV base, increased right ventricular (RV) apical sphericity, and decreased RV basal sphericity. Multivariate LDA showed that the optimal discriminative model included only RV apical ejection fraction and one PCA mode associated with a more circular and dilated LV base (AUC = 0.77). PRVI did not add value, and shape changes associated with increased PRVI were not predictive of adverse outcomes. CONCLUSION: Pathological remodelling patterns in patients with rToF are significantly associated with adverse events, independent of PRVI. Mechanisms related to incident events include LV basal dilation with a reduced RV apical ejection fraction.

Published
2022

3. Unsupervised Domain Adaptation from Axial to Short-Axis Multi-Slice Cardiac MR Images by Incorporating Pretrained Task Networks

Author

Koehler, Sven, Hussain, Tarique, Blair, Zach, Huffaker, Tyler, Ritzmann, Florian, Tandon, Animesh, Pickardt, Thomas, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Wolf, Ivo, and Engelhardt, Sandy

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Anisotropic multi-slice Cardiac Magnetic Resonance (CMR) Images are conventionally acquired in patient-specific short-axis (SAX) orientation. In specific cardiovascular diseases that affect right ventricular (RV) morphology, acquisitions in standard axial (AX) orientation are preferred by some investigators, due to potential superiority in RV volume measurement for treatment planning. Unfortunately, due to the rare occurrence of these diseases, data in this domain is scarce. Recent research in deep learning-based methods mainly focused on SAX CMR images and they had proven to be very successful. In this work, we show that there is a considerable domain shift between AX and SAX images, and therefore, direct application of existing models yield sub-optimal results on AX samples. We propose a novel unsupervised domain adaptation approach, which uses task-related probabilities in an attention mechanism. Beyond that, cycle consistency is imposed on the learned patient-individual 3D rigid transformation to improve stability when automatically re-sampling the AX images to SAX orientations. The network was trained on 122 registered 3D AX-SAX CMR volume pairs from a multi-centric patient cohort. A mean 3D Dice of $0.86\pm{0.06}$ for the left ventricle, $0.65\pm{0.08}$ for the myocardium, and $0.77\pm{0.10}$ for the right ventricle could be achieved. This is an improvement of $25\%$ in Dice for RV in comparison to direct application on axial slices. To conclude, our pre-trained task module has neither seen CMR images nor labels from the target domain, but is able to segment them after the domain gap is reduced. Code: https://github.com/Cardio-AI/3d-mri-domain-adaptation, Comment: Accepted for IEEE Transaction on Medical Imaging (TMI) 2021 on 13.01.2021

Published
2021
Full Text
View/download PDF

4. How well do U-Net-based segmentation trained on adult cardiac magnetic resonance imaging data generalise to rare congenital heart diseases for surgical planning?

Author

Koehler, Sven, Tandon, Animesh, Hussain, Tarique, Latus, Heiner, Pickardt, Thomas, Sarikouch, Samir, Beerbaum, Philipp, Greil, Gerald, Engelhardt, Sandy, and Wolf, Ivo

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Planning the optimal time of intervention for pulmonary valve replacement surgery in patients with the congenital heart disease Tetralogy of Fallot (TOF) is mainly based on ventricular volume and function according to current guidelines. Both of these two biomarkers are most reliably assessed by segmentation of 3D cardiac magnetic resonance (CMR) images. In several grand challenges in the last years, U-Net architectures have shown impressive results on the provided data. However, in clinical practice, data sets are more diverse considering individual pathologies and image properties derived from different scanner properties. Additionally, specific training data for complex rare diseases like TOF is scarce. For this work, 1) we assessed the accuracy gap when using a publicly available labelled data set (the Automatic Cardiac Diagnosis Challenge (ACDC) data set) for training and subsequent applying it to CMR data of TOF patients and vice versa and 2) whether we can achieve similar results when applying the model to a more heterogeneous data base. Multiple deep learning models were trained with four-fold cross validation. Afterwards they were evaluated on the respective unseen CMR images from the other collection. Our results confirm that current deep learning models can achieve excellent results (left ventricle dice of $0.951\pm{0.003}$/$0.941\pm{0.007}$ train/validation) within a single data collection. But once they are applied to other pathologies, it becomes apparent how much they overfit to the training pathologies (dice score drops between $0.072\pm{0.001}$ for the left and $0.165\pm{0.001}$ for the right ventricle)., Comment: Accepted for SPIE Medical Imaging 2020

Published
2020

5. Clinical impact of novel cardiovascular magnetic resonance technology on patients with congenital heart disease: a scientific statement of the Association for European Pediatric and Congenital Cardiology and the European Association of Cardiovascular Imaging of the European Society of Cardiology

Author

Voges, Inga, Raimondi, Francesca, McMahon, Colin J, Ait-Ali, Lamia, Babu-Narayan, Sonya V, Botnar, René M, Burkhardt, Barbara, Gabbert, Dominik D, Grosse-Wortmann, Lars, Hasan, Hosan, Hansmann, Georg, Helbing, Willem A, Krupickova, Sylvia, Latus, Heiner, Martini, Nicola, Martins, Duarte, Muthurangu, Vivek, Ojala, Tiina, Ooij, Pim van, and Pushparajah, Kuberan

Subjects
CONGENITAL heart disease diagnosis, MEDICAL protocols, REFERENCE values, MAGNETIC resonance imaging, MEDICAL societies, DECISION making in clinical medicine, VIRTUAL reality, DEEP learning, MYOCARDIUM, THREE-dimensional printing, DIGITAL image processing, AUGMENTED reality, CHILDREN, ADULTS
Abstract

Cardiovascular magnetic resonance (CMR) imaging is recommended in patients with congenital heart disease (CHD) in clinical practice guidelines as the imaging standard for a large variety of diseases. As CMR is evolving, novel techniques are becoming available. Some of them are already used clinically, whereas others still need further evaluation. In this statement, the authors give an overview of relevant new CMR techniques for the assessment of CHD. Studies with reference values for these new techniques are listed in the Supplementary data online, supplement. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Relationship Between Shape and Contractile Function in Left Ventricles of Patients with Repaired Tetralogy of Fallot: Cardiac Mri-derived Computational Study

Author

Gusseva, Maria, primary, Hussain, Tarique, additional, Pickardt, Thomas, additional, Beerbaum, Philipp, additional, Sarikouch, Samir, additional, Latus, Heiner, additional, Greil, Gerald, additional, Chabiniok, Radomir, additional, Chapelle, Dominque, additional, Lamata, Pablo, additional, and Tandon, Animesh, additional

Published
2024
Full Text
View/download PDF

13. Left Ventricular Physiology and Ventricular‐Vascular Interactions in Young Patients After Heart Transplantation

Author

Latus, Heiner, primary, Raap, Ramona, additional, Klingel, Karin, additional, Happel, Christoph, additional, Moysich, Axel, additional, Khalil, Markus, additional, Kerst, Gunter, additional, Milla, Jakob, additional, Skrzypek, Susanne, additional, Thul, Josef, additional, Jux, Christian, additional, Schranz, Dietmar, additional, and Apitz, Christian, additional

Published
2023
Full Text
View/download PDF

32. Impact of Right Ventricular Pressure Load After Repair of Tetralogy of Fallot

Author

Latus, Heiner, primary, Stammermann, Jana, additional, Voges, Inga, additional, Waschulzik, Birgit, additional, Gutberlet, Matthias, additional, Diller, Gerhard‐Paul, additional, Schranz, Dietmar, additional, Ewert, Peter, additional, Beerbaum, Philipp, additional, Kühne, Titus, additional, Sarikouch, Samir, additional, Kerst, Gunter, additional, Kanaan, Majed, additional, Lebherz, Corinna, additional, Rüffer, André, additional, Gkalpakiotis, Dimitrios, additional, Schedifka, Andrea, additional, Buheitel, Gernot, additional, Streble, Joachim, additional, Willing, Rainer, additional, Schubert, Stephan, additional, Laser, Kai Thorsten, additional, Sandica, Eugen, additional, Trusen, Burkhard, additional, Berger, Felix, additional, Miera, Oliver, additional, Ovroutski, Stanislav, additional, Schmitt, Katharina, additional, Photiadis, Joachim, additional, Opgen‐Rhein, Bernd, additional, Weiss, Katja, additional, Klaassen, Sabine, additional, Berns, Christoph, additional, Boeckel, Thomas, additional, Haverkämper, Guido, additional, Kästner, Andreas, additional, Koch, Heike, additional, Peters, Björn, additional, Schmidt, Florian, additional, Timme, Jens, additional, Engel, Konstanze, additional, Franzbach, Birgit, additional, Senft, Gabriela, additional, Beyer, Frank, additional, Winter, Klaus, additional, Breuer, Johannes, additional, Schneider, Martin, additional, Bahlmann, Jens, additional, Griese, Eberhard, additional, Lê, Trong Phi, additional, Hebe, Joachim, additional, Nürnberg, Jan‐Hendrik, additional, Magsaam, Annette, additional, Müller, Ronald, additional, Potthoff, Ludger, additional, Voigt, Renate, additional, Krüger, Tim, additional, Gerleve, Hubert, additional, Kleideiter, Ulrich, additional, Schneider‐Kulla, Dirk, additional, Krülls‐Münch, Jürgen, additional, Menke, Thomas, additional, Lehn, Martin, additional, Heilmann, Antje, additional, Tomczak, Helge, additional, Tarusinov, Gleb, additional, Scheid, Michael, additional, Mayatepek, Ertan, additional, Pillekamp, Frank, additional, Lichtenberg, Artur, additional, Terpeluk, Christiane, additional, Kolterer, Bruno, additional, Dittrich, Sven, additional, Gundlach, Ulrike, additional, Cesnjevar, Robert, additional, Müntjes, Carsten, additional, Morf, Geert, additional, Esmaeili, Anoosh, additional, Backhoff, Stephan, additional, Stiller, Brigitte, additional, Beyersdorf, Friedhelm, additional, Kroll, Johannes, additional, Häffner, Nicole, additional, Siaplaouras, Jannos, additional, Masri‐Zada, Antje, additional, Jux, Christian, additional, Böning, Andreas, additional, Akintürk, Hakan, additional, Paul, Thomas, additional, Sigler, Matthias, additional, Tirilomis, Theodor, additional, Schürer, Gabriele, additional, Hartmann, Johannes, additional, Grabitz, Ralph, additional, Liebaug, Uta, additional, Rotzsch, Claudius, additional, Kozlik‐Feldmann, Rainer, additional, Rickers, Carsten, additional, Mir, Thomas, additional, Hübler, Michael, additional, Sachweh, Jörg, additional, Renz, Stefan, additional, Schemm, Andreas, additional, Friedrich, Bernd, additional, Schlobohm, Otmar, additional, Böthig, Dietmar, additional, Wermter, Burkhard, additional, Kelter‐Klöpping, Andrea, additional, Horke, Alexander, additional, Bauersachs, Johann, additional, Westhoff‐Bleck, Mechthild, additional, Gorenflo, Matthias, additional, Karck, Matthias, additional, Loukanov, Tsvetomir, additional, Schrüfer, Hermann, additional, Wilken, Martin, additional, Abdul‐Khaliq, Hashim, additional, Rädle‐Hurst, Tanja, additional, Rentzsch, Axel, additional, Schäfers, Hans‐Joachim, additional, Reichert, Hagen, additional, Vilser, Daniel, additional, Kriebel, Thomas, additional, Boysen, Arnulf, additional, Uebing, Anselm, additional, Attmann, Tim, additional, Cremer, Joachim Thomas, additional, Scheewe, Jens, additional, Buchholz‐Berdau, Regina, additional, Möller, Peter, additional, Horter, Thorsten, additional, Brockmeier, Konrad, additional, Bennink, Gerardus B. W. E, additional, Baldus, Stephan, additional, Gillor, Alex, additional, Niehues, Tim, additional, Lawrenz, Wolfgang, additional, Leidig, Steffen, additional, Dähnert, Ingo, additional, Riede, Frank‐Thomas, additional, Kostelka, Martin, additional, Kändler, Liane, additional, Bethge, Martin, additional, Köster, Stefan, additional, Schröder, Christoph, additional, Karstedt, Jens, additional, Seitz, Uwe, additional, Kampmann, Christoph, additional, Dohle, Daniel‐Sebastian, additional, Stahl, Frank, additional, Abedini, Mojtaba, additional, Müller‐Scholden, Joachim, additional, Hager, Alfred, additional, Huntgeburth, Michael, additional, Kaemmerer, Harald, additional, Nagdyman, Nicole, additional, Schoetzau, Jörg, additional, Tutarel, Oktay, additional, Lange, Rüdiger, additional, Hörer, Jürgen, additional, Haas, Nikolaus A, additional, Hauser, Michael, additional, Roithmaier, Alexander, additional, Kehl, Hans‐Gerd, additional, Lammers, Astrid, additional, Malec, Edward, additional, Baumgartner, Helmut, additional, Diller, Gerhard, additional, Bahle, Roswitha, additional, Hofner, Gerald, additional, Zink, Stefan, additional, Reif, Roland, additional, Singer, Helmut, additional, Parlasca, Christoph, additional, Freund, Matthias W, additional, Schumacher, Michael, additional, Dewald, Oliver, additional, Darrelmann, Christine, additional, Willmann, Olaf, additional, Schmiedl, Norbert, additional, Quick, Peter, additional, Hillebrand, Dirk, additional, Michele Eiselt, Stephan, additional, Nekarda, Torsten, additional, Eberhard, Michael, additional, Baier, Georg, additional, Uhlemann, Frank, additional, Tzanavaros, Ioannis, additional, Beyer, Alexander, additional, Binz, Gudrun, additional, Hess, Steffen, additional, Teufel, Thomas, additional, Handke, Ronald‐Peter, additional, Hofbeck, Michael, additional, Kaulitz, Renate, additional, Sieverding, Ludger, additional, Schlensak, Christian, additional, Apitz, Christian, additional, Kaestner, Michael, additional, Holtvogt, Jürgen, additional, Wippermann, Carl‐Friedrich, additional, Hinz, Sönke, additional, Heusch, Andreas, additional, Wirbelauer, Johannes, additional, and Brosi, Wolfgang, additional

Published
2022
Full Text
View/download PDF

33. Additional file 1 of Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot

Author

Mîra, Anna, Lamata, Pablo, Pushparajah, Kuberan, Abraham, Georgina, Mauger, Charlène A., McCulloch, Andrew D., Omens, Jeffrey H., Bissell, Malenka M., Blair, Zach, Huffaker, Tyler, Tandon, Animesh, Engelhardt, Sandy, Koehler, Sven, Pickardt, Thomas, Beerbaum, Philipp, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Young, Alistair A., and Hussain, Tarique

Abstract

Additional file 1. Additional data.

Published
2022
Full Text
View/download PDF

34. Additional file 2 of Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot

Author

Mîra, Anna, Lamata, Pablo, Pushparajah, Kuberan, Abraham, Georgina, Mauger, Charlène A., McCulloch, Andrew D., Omens, Jeffrey H., Bissell, Malenka M., Blair, Zach, Huffaker, Tyler, Tandon, Animesh, Engelhardt, Sandy, Koehler, Sven, Pickardt, Thomas, Beerbaum, Philipp, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Young, Alistair A., and Hussain, Tarique

Abstract

Additional file 2: Video S1. Animations of shape variations associated with adverse outcomes.

Published
2022
Full Text
View/download PDF

37. Le CÅ“ur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot

Author

Mîra, Anna, primary, Lamata, Pablo, additional, Pushparajah, Kuberan, additional, Abraham, Georgina, additional, Mauger, Charlène A., additional, McCulloch, Andrew D., additional, Omens, Jeffrey H., additional, Bissell, Malenka M., additional, Blair, Zach, additional, Huffaker, Tyler, additional, Tandon, Animesh, additional, Engelhardt, Sandy, additional, Koehler, Sven, additional, Pickardt, Thomas, additional, Beerbaum, Philipp, additional, Sarikouch, Samir, additional, Latus, Heiner, additional, Greil, Gerald, additional, Young, Alistair A., additional, and Hussain, Tarique, additional

Published
2022
Full Text
View/download PDF

38. Real-time CMR guidance for intracardiac and great vessel pressure mapping in patients with congenital heart disease using an MR conditional guidewire—results of 25 patients

Author

Meierhofer, Christian, primary, Belker, Kristina, additional, Shehu, Nerejda, additional, Latus, Heiner, additional, Mkrtchyan, Naira, additional, Naumann, Susanne, additional, Martinoff, Stefan, additional, Stern, Heiko, additional, Eicken, Andreas, additional, and Ewert, Peter, additional

Published
2021
Full Text
View/download PDF

42. Exercise-dependent changes in ventricular–arterial coupling and aortopulmonary collateral flow in Fontan patients: a real-time CMR study.

Author

Latus, Heiner, Hofmann, Lucas, Gummel, Kerstin, Khalil, Markus, Yerebakan, Can, Waschulzik, Birgit, Schranz, Dietmar, Voges, Inga, Jux, Christian, and Reich, Bettina

Subjects
PULMONARY circulation, VENA cava superior, COLLATERAL circulation, MAGNETIC resonance imaging, EXERCISE, RESEARCH funding, EMPLOYEES' workload, AORTA, CARDIOPULMONARY bypass, ERGOMETRY, VENA cava inferior, HEMODYNAMICS, HEART failure
Abstract

Aims Inefficient ventricular–arterial (V–A) coupling has been described in Fontan patients and may result in adverse haemodynamics. A varying amount of aortopulmonary collateral (APC) flow is also frequently present that increases volume load of the single ventricle. The aim of the study was to assess changes in V–A coupling and APC flow during exercise CMR. Methods and results Eighteen Fontan patients (age 24 ± 3 years) and 14 controls (age 23 ± 4 years) underwent exercise CMR using a cycle ergometer. Ventricular volumetry and flow measurements in the ascending aorta (AAO), inferior (IVC), and superior (SVC) vena cava were assessed using real-time sequences during stepwise increases in work load. Measures of systemic arterial elastance Ea, ventricular elastance Ees, and V–A coupling (Ea/Ees) were assessed. APC flow was quantified as AAO − (SVC + IVC). Ea remained unchanged during all levels of exercise in both groups (P = 0.39 and P = 0.11). Ees increased in both groups (P = 0.001 and P < 0.001) with exercise but was lower in the Fontan group (P = 0.04). V–A coupling was impaired in Fontan patients at baseline (P = 0.04). Despite improvement during exercise (P = 0.002) V–A coupling remained impaired compared with controls (P = 0.001). Absolute APC flow in Fontan patients did not change during exercise even at maximum work load (P = 0.98). Conclusions Inefficient V–A coupling was already present at rest in Fontan patients and aggravated during exercise due to a limited increase in ventricular contractility which demonstrates the importance of a limited functional reserve of the single ventricle. APC flow remained unchanged suggesting no further increase in volume load during exercise. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

46. Abstract 8928: Le Coeur En Sabot: Shape and Regional Function Predict Adverse Outcome in Patients with Repaired Tetralogy of Fallot

Author

Mira, Anna, primary, Lamata, Pablo, additional, Young, Alistair, additional, Pickardt, Thomas, additional, Tandon, Animesh A, additional, Sarikouch, Samir, additional, Omens, Jeff, additional, Latus, Heiner, additional, Beerbaum, Philipp B, additional, Koehler, Sven, additional, Bissell, Malenka, additional, Blair, Zachary, additional, Huffaker, Tyler, additional, Pushparajah, Kuberan, additional, Mauger, Charlene, additional, Abraham, Georgina, additional, McCulloch, Andrew, additional, Greil, Gerald, additional, Engelhardt, Sandy, additional, and Hussain, Mohammad, additional

Published
2021
Full Text
View/download PDF

47. Favorable Atrial Remodeling After Percutaneous Pulmonary Valve Implantation and Its Association With Changes in Exercise Capacity and Right Ventricular Function

Author

Latus, Heiner, primary, Born, Danik, additional, Shehu, Nerejda, additional, Stern, Heiko, additional, Hager, Alfred, additional, Georgiev, Stainimir, additional, Tanase, Daniel, additional, Meierhofer, Christian, additional, Ewert, Peter, additional, Eicken, Andreas, additional, and Tutarel, Oktay, additional

Published
2021
Full Text
View/download PDF

48. Unsupervised Domain Adaptation From Axial to Short-Axis Multi-Slice Cardiac MR Images by Incorporating Pretrained Task Networks

Author

Koehler, Sven, primary, Hussain, Tarique, additional, Blair, Zach, additional, Huffaker, Tyler, additional, Ritzmann, Florian, additional, Tandon, Animesh, additional, Pickardt, Thomas, additional, Sarikouch, Samir, additional, Latus, Heiner, additional, Greil, Gerald, additional, Wolf, Ivo, additional, and Engelhardt, Sandy, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results