768 results on '"Lau, Bryan"'
Search Results
2. Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial.
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Park, Han-Sol, Yin, Anna, Barranta, Caelan, Lee, John, Caputo, Christopher, Sachithanandham, Jaiprasath, Li, Maggie, Yoon, Steve, Sitaras, Ioannis, Jedlicka, Anne, Eby, Yolanda, Ram, Malathi, Fernandez, Reinaldo, Baker, Owen, Shenoy, Aarthi, Mosnaim, Giselle, Fukuta, Yuriko, Patel, Bela, Heath, Sonya, Levine, Adam, Meisenberg, Barry, Spivak, Emily, Anjan, Shweta, Huaman, Moises, Blair, Janis, Zand, Martin, Cachay, Edward, Raval, Jay, Kassaye, Seble, Marshall, Christi, Yarava, Anusha, Lane, Karen, McBee, Nichol, Gawad, Amy, Karlen, Nicky, Singh, Atika, Ford, Daniel, Jabs, Douglas, Appel, Lawrence, Shade, David, Lau, Bryan, Ehrhardt, Stephan, Baksh, Sheriza, Shapiro, Janna, Ou, Jiangda, Na, Yu, Knoll, Maria, Ornelas-Gatdula, Elysse, Arroyo-Curras, Netzahualcoyotl, Gniadek, Thomas, Caturegli, Patrizio, Wu, Jinke, Ndahiro, Nelson, Betenbaugh, Michael, Hanley, Daniel, Casadevall, Arturo, Shoham, Shmuel, Bloch, Evan, Gebo, Kelly, Tobian, Aaron, Laeyendecker, Oliver, Pekosz, Andrew, Klein, Sabra, Sullivan, David, Paxton, James, Gerber, Jonathan, Petrini, Joann, Broderick, Patrick, Rausch, William, Cordisco, Marie, Hammel, Jean, Greenblatt, Benjamin, Cluzet, Valerie, Cruser, Daniel, Oei, Kevin, Abinante, Matthew, Hammitt, Laura, Sutcliffe, Catherine, Currier, Judith, Forthal, Donald, and Ziman, Alyssa
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COVID-19 ,Immunoglobulins ,Immunotherapy ,Humans ,COVID-19 ,COVID-19 Serotherapy ,Antibodies ,Viral ,Immunization ,Passive ,Hospitalization ,SARS-CoV-2 ,Male ,Female ,Middle Aged ,Adult ,Immunoglobulin G ,Antibodies ,Neutralizing ,Double-Blind Method ,Aged ,Blood Donors ,Outpatients - Abstract
BACKGROUNDCOVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion antibody levels sufficient to prevent disease progression are not defined.METHODSThis secondary analysis correlated donor and recipient antibody levels to hospitalization risk among unvaccinated, seronegative CCP recipients within the outpatient, double-blind, randomized clinical trial that compared CCP to control plasma. The majority of COVID-19 CCP arm hospitalizations (15/17, 88%) occurred in this unvaccinated, seronegative subgroup. A functional cutoff to delineate recipient high versus low posttransfusion antibody levels was established by 2 methods: (i) analyzing virus neutralization-equivalent anti-Spike receptor-binding domain immunoglobulin G (anti-S-RBD IgG) responses in donors or (ii) receiver operating characteristic (ROC) curve analysis.RESULTSSARS-CoV-2 anti-S-RBD IgG antibody was volume diluted 21.3-fold into posttransfusion seronegative recipients from matched donor units. Virus-specific antibody delivered was approximately 1.2 mg. The high-antibody recipients transfused early (symptom onset within 5 days) had no hospitalizations. A CCP-recipient analysis for antibody thresholds correlated to reduced hospitalizations found a statistical significant association between early transfusion and high antibodies versus all other CCP recipients (or control plasma), with antibody cutoffs established by both methods-donor-based virus neutralization cutoffs in posttransfusion recipients (0/85 [0%] versus 15/276 [5.6%]; P = 0.03) or ROC-based cutoff (0/94 [0%] versus 15/267 [5.4%]; P = 0.01).CONCLUSIONIn unvaccinated, seronegative CCP recipients, early transfusion of plasma units in the upper 30% of study donors antibody levels reduced outpatient hospitalizations. High antibody level plasma units, given early, should be reserved for therapeutic use.TRIAL REGISTRATIONClinicalTrials.gov NCT04373460.FUNDINGDepartment of Defense (W911QY2090012); Defense Health Agency; Bloomberg Philanthropies; the State of Maryland; NIH (3R01AI152078-01S1, U24TR001609-S3, 1K23HL151826NIH); the Mental Wellness Foundation; the Moriah Fund; Octapharma; the Healthnetwork Foundation; the Shear Family Foundation; the NorthShore Research Institute; and the Rice Foundation.
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- 2024
3. An injury-responsive mmp14b enhancer is required for heart regeneration.
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Zlatanova, Ivana, Sun, Fei, Wu, Roland, Chen, Xiaoxin, Lau, Bryan, Colombier, Pauline, Sinha, Tanvi, Xu, Shan-Mei, Huang, Guo, Black, Brian, Materna, Stefan, and Celona, Barbara
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Animals ,Mice ,Zebrafish ,Endothelial Cells ,Myocardium ,Myocytes ,Cardiac ,Cell Proliferation ,Regeneration ,Mammals - Abstract
Mammals have limited capacity for heart regeneration, whereas zebrafish have extraordinary regeneration abilities. During zebrafish heart regeneration, endothelial cells promote cardiomyocyte cell cycle reentry and myocardial repair, but the mechanisms responsible for promoting an injury microenvironment conducive to regeneration remain incompletely defined. Here, we identify the matrix metalloproteinase Mmp14b as an essential regulator of heart regeneration. We identify a TEAD-dependent mmp14b endothelial enhancer induced by heart injury in zebrafish and mice, and we show that the enhancer is required for regeneration, supporting a role for Hippo signaling upstream of mmp14b. Last, we show that MMP-14 function in mice is important for the accumulation of Agrin, an essential regulator of neonatal mouse heart regeneration. These findings reveal mechanisms for extracellular matrix remodeling that promote heart regeneration.
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- 2023
4. Association of Alcohol Use with COVID-19 Infection and Hospitalization Among People Living with HIV in the United States, 2020
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Xia, Chunyi, Chander, Geetanjali, Hutton, Heidi E., McCaul, Mary E., Delaney, Joseph A., Mayer, Kenneth H., Jacobson, Jeffrey M., Puryear, Sarah, Crane, Heidi M., Shapiro, Adrienne E., Cachay, Edward R., Lau, Bryan, Napravnik, Sonia, Saag, Michael, and Lesko, Catherine R.
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- 2024
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5. Clinical management and outcomes of HIV-positive patients newly diagnosed with prostate cancer: a single institution experience
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Markowski, Mark C., Pirsl, Filip, Keruly, Jeanne C., Chander, Geetanjali, Moore, Richard D., Lau, Bryan, and Joshu, Corinne E.
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- 2024
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6. The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort
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Knapp, Emily A, Kress, Amii M, Parker, Corette B, Page, Grier P, McArthur, Kristen, Gachigi, Kennedy K, Alshawabkeh, Akram N, Aschner, Judy L, Bastain, Theresa M, Breton, Carrie V, Bendixsen, Casper G, Brennan, Patricia A, Bush, Nicole R, Buss, Claudia, Camargo, Carlos A, Catellier, Diane, Cordero, José F, Croen, Lisa, Dabelea, Dana, Deoni, Sean, D’Sa, Viren, Duarte, Cristiane S, Dunlop, Anne L, Elliott, Amy J, Farzan, Shohreh F, Ferrara, Assiamira, Ganiban, Jody M, Gern, James E, Giardino, Angelo P, Towe-Goodman, Nissa R, Gold, Diane R, Habre, Rima, Hamra, Ghassan B, Hartert, Tina, Herbstman, Julie B, Hertz-Picciotto, Irva, Hipwell, Alison E, Karagas, Margaret R, Karr, Catherine J, Keenan, Kate, Kerver, Jean M, Koinis-Mitchell, Daphne, Lau, Bryan, Lester, Barry M, Leve, Leslie D, Leventhal, Bennett, LeWinn, Kaja Z, Lewis, Johnnye, Litonjua, Augusto A, Lyall, Kristen, Madan, Juliette C, McEvoy, Cindy T, McGrath, Monica, Meeker, John D, Miller, Rachel L, Morello-Frosch, Rachel, Neiderhiser, Jenae M, O’Connor, Thomas G, Oken, Emily, O’Shea, Michael, Paneth, Nigel, Porucznik, Christina A, Sathyanarayana, Sheela, Schantz, Susan L, Spindel, Eliot R, Stanford, Joseph B, Stroustrup, Annemarie, Teitelbaum, Susan L, Trasande, Leonardo, Volk, Heather, Wadhwa, Pathik D, Weiss, Scott T, Woodruff, Tracey J, Wright, Rosalind J, Zhao, Qi, Jacobson, Lisa P, and Outcomes, on behalf of program collaborators for Environmental Influences on Child Health
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Public Health ,Health Sciences ,Human Genome ,Prevention ,Nutrition ,Pediatric ,Behavioral and Social Science ,Genetics ,Clinical Research ,Pediatric Research Initiative ,2.2 Factors relating to the physical environment ,Aetiology ,Good Health and Well Being ,Child ,Humans ,United States ,Environmental Exposure ,Cohort Studies ,Child Health ,Air Pollution ,Outcome Assessment ,Health Care ,adolescent ,child ,child development ,child health ,child well-being ,cohort studies ,environmental exposure ,epidemiologic methods ,Mathematical Sciences ,Medical and Health Sciences ,Epidemiology - Abstract
The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children's health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7-11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).
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- 2023
7. Optical properties of defects in solids via quantum embedding with good active space orbitals
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Lau, Bryan T. G., Busemeyer, Brian, and Berkelbach, Timothy C.
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Condensed Matter - Materials Science ,Physics - Chemical Physics - Abstract
The study of isolated defects in solids is a natural target for classical or quantum embedding methods that treat the defect at a high level of theory and the rest of the solid at a lower level of theory. Here, in the context of active-space-based quantum embeddings, we study the performance of three active-space orbital selection schemes based on canonical (energy-ordered) orbitals, local orbitals defined in the spirit of density matrix embedding theory, and approximate natural transition orbitals. Using equation-of-motion coupled-cluster theory with single and double excitations (CCSD), we apply these active space selection schemes to the calculation of the vertical singlet excitation energy of a substitutional carbon dimer defect in hexagonal boron nitride, an oxygen vacancy in magnesium oxide, and a carbon vacancy in diamond. Especially when used in combination with a simple composite correction, we find that the best performing schemes can predict the excitation energy to about 0.1-0.2 eV of its converged value using only a few hundred orbitals, even when the full supercell has thousands of orbitals, which amounts to many-orders-of-magnitude computational savings when using correlated electronic structure theories. When compared to assigned experimental spectra and accounting for vibrational corrections, we find that CCSD predicts excitation energies that are accurate to about 0.1-0.3 eV, which is comparable to its performance in molecules and bulk solids., Comment: 8 pages, 4 figures
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- 2023
8. What does it mean to be 'representative'?
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Rudolph, Jacqueline E., Zhong, Yongqi, Duggal, Priya, Mehta, Shruti H., and Lau, Bryan
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Statistics - Applications - Abstract
Medical and population health science researchers frequently make ambiguous statements about whether they believe their study sample or results are "representative" of some (implicit or explicit) target population. Here, we provide a comprehensive definition of representativeness, with the goal of capturing the different ways in which a study can be representative of a target population. We propose that a study is representative if the estimate obtained in the study sample is generalizable to the target population (either due to representative sampling, estimation of stratum specific effects, or quantitative methods to generalize or transport estimates) or the interpretation of the results is generalizable to the target population (based on fundamental scientific premises and substantive background knowledge). We explore this definition in the context of four COVID-19 studies, ranging from laboratory science to descriptive epidemiology. All statements regarding representativeness should make clear the way in which the study results generalize, the target population the results are being generalized to, and the assumptions that must hold for that generalization to be scientifically or statistically justifiable., Comment: 15 pages, 0 figures
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- 2022
9. Missing data interpolation in integrative multi-cohort analysis with disparate covariate information
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Smirnova, Ekaterina, Zhong, Yongqi, Alsaadawi, Rasha, Ning, Xu, Kress, Amii, Kuiper, Jordan, Zhang, Mingyu, Lyall, Kristen, Martenies, Sheenas, Alshawabkeh, Akram, Bulka, Catherine, Camargo, Carlos, Choi, Jaeun, Colicino, Elena, Dunlop, Anne, Elliott, Michael, Ferrara, Assiamira, Gebrestadik, Tebeb, Gui, Jiang, Harrall, Kylie, Hartert, Tina, Lester, Barry, Manigault, Andrew, Manjourides, Justin, Ni, Yu, Wright, Rosalind, Wright, Robert, Ziegler, Katherine, and Lau, Bryan
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Statistics - Methodology - Abstract
Integrative analysis of datasets generated by multiple cohorts is a widely-used approach for increasing sample size, precision of population estimators, and generalizability of analysis results in epidemiological studies. However, often each individual cohort dataset does not have all variables of interest for an integrative analysis collected as a part of an original study. Such cohort-level missingness poses methodological challenges to the integrative analysis since missing variables have traditionally: (1) been removed from the data for complete case analysis; or (2) been completed by missing data interpolation techniques using data with the same covariate distribution from other studies. In most integrative-analysis studies, neither approach is optimal as it leads to either loosing the majority of study covariates or challenges in specifying the cohorts following the same distributions. We propose a novel approach to identify the studies with same distributions that could be used for completing the cohort-level missing information. Our methodology relies on (1) identifying sub-groups of cohorts with similar covariate distributions using cohort identity random forest prediction models followed by clustering; and then (2) applying a recursive pairwise distribution test for high dimensional data to these sub-groups. Extensive simulation studies show that cohorts with the same distribution are correctly grouped together in almost all simulation settings. Our methods' application to two ECHO-wide Cohort Studies reveals that the cohorts grouped together reflect the similarities in study design. The methods are implemented in R software package relate.
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- 2022
10. Transfusing convalescent plasma as post-exposure prophylaxis against SARS-CoV-2 infection: a double-blinded, phase 2 randomized, controlled trial
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Shoham, Shmuel, Bloch, Evan M, Casadevall, Arturo, Hanley, Daniel, Lau, Bryan, Gebo, Kelly, Cachay, Edward, Kassaye, Seble G, Paxton, James H, Gerber, Jonathan, Levine, Adam C, Naeim, Arash, Currier, Judith, Patel, Bela, Allen, Elizabeth S, Anjan, Shweta, Appel, Lawrence, Baksh, Sheriza, Blair, Paul W, Bowen, Anthony, Broderick, Patrick, Caputo, Christopher A, Cluzet, Valerie, Cordisco, Marie Elena, Cruser, Daniel, Ehrhardt, Stephan, Forthal, Donald, Fukuta, Yuriko, Gawad, Amy L, Gniadek, Thomas, Hammel, Jean, Huaman, Moises A, Jabs, Douglas A, Jedlicka, Anne, Karlen, Nicky, Klein, Sabra, Laeyendecker, Oliver, Lane, Karen, McBee, Nichol, Meisenberg, Barry, Merlo, Christian, Mosnaim, Giselle, Park, Han-Sol, Pekosz, Andrew, Petrini, Joann, Rausch, William, Shade, David M, Shapiro, Janna R, Singleton, J Robinson, Sutcliffe, Catherine, Thomas, David L, Yarava, Anusha, Zand, Martin, Zenilman, Jonathan M, Tobian, Aaron AR, and Sullivan, David J
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Biomedical and Clinical Sciences ,Clinical Sciences ,Biodefense ,Lung ,Pneumonia ,Clinical Trials and Supportive Activities ,Vaccine Related ,Prevention ,Infectious Diseases ,Emerging Infectious Diseases ,Clinical Research ,Infection ,Good Health and Well Being ,Humans ,Adolescent ,Adult ,SARS-CoV-2 ,COVID-19 ,Post-Exposure Prophylaxis ,COVID-19 Serotherapy ,Double-Blind Method ,Immunization ,Passive ,post-exposure-prophylaxis ,convalescent plasma ,transfusion ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundThe efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent plasma (CCP) for preventing infection in exposed, uninfected individuals is unknown. CCP might prevent infection when administered before symptoms or laboratory evidence of infection.MethodsThis double-blinded, phase 2 randomized, controlled trial (RCT) compared the efficacy and safety of prophylactic high titer (≥1:320 by Euroimmun ELISA) CCP with standard plasma. Asymptomatic participants aged ≥18 years with close contact exposure to a person with confirmed coronavirus disease 2019 (COVID-19) in the previous 120 hours and negative SARS-CoV-2 test within 24 hours before transfusion were eligible. The primary outcome was new SARS-CoV-2 infection.ResultsIn total, 180 participants were enrolled; 87 were assigned to CCP and 93 to control plasma, and 170 transfused at 19 sites across the United States from June 2020 to March 2021. Two were excluded for screening SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) positivity. Of the remaining 168 participants, 12/81 (14.8%) CCP and 13/87 (14.9%) control recipients developed SARS-CoV-2 infection; 6 (7.4%) CCP and 7 (8%) control recipients developed COVID-19 (infection with symptoms). There were no COVID-19-related hospitalizations in CCP and 2 in control recipients. Efficacy by restricted mean infection free time (RMIFT) by 28 days for all SARS-CoV-2 infections (25.3 vs 25.2 days; P = .49) and COVID-19 (26.3 vs 25.9 days; P = .35) was similar for both groups.ConclusionsAdministration of high-titer CCP as post-exposure prophylaxis, although appearing safe, did not prevent SARS-CoV-2 infection.Clinical trials registrationNCT04323800.
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- 2023
11. COVID-19 and the HIV continuum in people living with HIV enrolled in Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) cohorts
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Lesko, Catherine R, Keruly, Jeanne C, Moore, Richard D, Shen, Nicola M, Pytell, Jarratt D, Lau, Bryan, Fojo, Anthony T, Mehta, Shruti H, Kipke, Michele, Baum, Marianna K, Shoptaw, Steven, Gorbach, Pamina M, Mustanski, Brian, Javanbakht, Marjan, Siminski, Suzanne, and Chander, Geetanjali
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Mental Health ,Substance Misuse ,Prevention ,HIV/AIDS ,Tobacco Smoke and Health ,Clinical Research ,Behavioral and Social Science ,Drug Abuse (NIDA only) ,Tobacco ,Mental health ,Good Health and Well Being ,Male ,Humans ,Medication Adherence ,Pandemics ,COVID-19 ,HIV Infections ,Substance-Related Disorders ,Antidepressant therapy ,Care cascade ,Depression ,Depressive symptoms ,Viral non-suppression ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Substance Abuse ,Biochemistry and cell biology ,Pharmacology and pharmaceutical sciences ,Epidemiology - Abstract
BackgroundThe COVID-19 pandemic disrupted the normal delivery of HIV care, altered social support networks, and caused economic insecurity. People with HIV (PWH) are vulnerable to such disruptions, particularly if they have a history of substance use. We describe engagement in care and adherence to antiretroviral therapy (ART) for PWH during the pandemic.MethodsFrom May 2020 to February 2021, 773 PWH enrolled in 6 existing cohorts completed 1495 surveys about substance use and engagement in HIV care during the COVID-19 pandemic. We described the prevalence and correlates of having missed a visit with an HIV provider in the past month and having missed a dose of ART in the past week.ResultsThirteen percent of people missed an HIV visit in the past month. Missing a visit was associated with unstable housing, food insecurity, anxiety, low resiliency, disruptions to mental health care, and substance use including cigarette smoking, hazardous alcohol use, cocaine, and cannabis use. Nineteen percent of people reported missing at least one dose of ART in the week prior to their survey. Missing a dose of ART was associated with being a man, low resiliency, disruptions to mental health care, cigarette smoking, hazardous alcohol use, cocaine, and cannabis use, and experiencing disruptions to substance use treatment.ConclusionsSocial determinants of health, substance use, and disruptions to mental health and substance use treatment were associated with poorer engagement in HIV care. Close attention to continuity of care during times of social disruption is especially critical for PWH.
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- 2022
12. The relationship of alcohol and other drug use during the COVID-19 pandemic among people with or at risk of HIV; A cross-sectional survey of people enrolled in Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) cohorts
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Pytell, Jarratt D, Shen, Nicola M, Keruly, Jeanne C, Lesko, Catherine R, Lau, Bryan, Fojo, Anthony T, Baum, Marianna K, Gorbach, Pamina M, Javanbakht, Marjan, Kipke, Michele, Kirk, Gregory D, Mustanski, Brian, Shoptaw, Steven, Siminski, Susanne, Moore, Richard D, and Chander, Geetanjali
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Biomedical and Clinical Sciences ,Clinical Sciences ,Alcoholism ,Alcohol Use and Health ,Substance Misuse ,Prevention ,HIV/AIDS ,Coronaviruses Disparities and At-Risk Populations ,Minority Health ,Social Determinants of Health ,Health Disparities ,Sexually Transmitted Infections ,Behavioral and Social Science ,Clinical Research ,Emerging Infectious Diseases ,Brain Disorders ,Drug Abuse (NIDA only) ,Clinical Trials and Supportive Activities ,Infectious Diseases ,Coronaviruses ,Mental health ,Good Health and Well Being ,Humans ,Cross-Sectional Studies ,HIV Infections ,Pandemics ,COVID-19 ,Substance-Related Disorders ,Cannabis ,Ethanol ,USA ,Alcohol use ,Stimulant use ,Opioid use ,Multiple substance use ,HIV ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Substance Abuse ,Biochemistry and cell biology ,Pharmacology and pharmaceutical sciences ,Epidemiology - Abstract
BackgroundAlcohol use during the COVID-19 pandemic increased. People living with HIV or at risk for HIV acquisition often have psycho-social and structural barriers or co-occurring substance use making them vulnerable to the adverse effects of alcohol. We describe factors associated with alcohol use during the COVID-19 pandemic in this group.MethodsFrom May 2020 to February 2021, 1984 people enrolled in 6 existing cohort studies completed surveys about alcohol and other drug use during the COVID-19 pandemic. We describe the past-month prevalence of no alcohol use, low-risk use, and hazardous use. We use multinomial regression to describe factors associated with low-risk or hazardous alcohol use relative to no alcohol use.ResultsForty-five percent of participants reported no alcohol use, 33% low-risk use, and 22% hazardous use in the past 30 days. Cannabis and stimulant use were associated with a higher prevalence of low-risk use relative to no use. Tobacco, stimulant, cannabis use and recent overdose were associated with a higher prevalence of hazardous use relative to no use. Substance use treatment and living with HIV were associated with a lower prevalence of low-risk or hazardous use relative to no use.ConclusionsStimulant use was strongly associated with a higher prevalence of hazardous alcohol use while engagement in substance use treatment or living with HIV was associated with a lower prevalence. Ascertaining hazardous alcohol and other drug use, particularly stimulants, in clinical care could identify people at higher risk for adverse outcome and harm reduction counseling.
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- 2022
13. Allowing Physicians to Choose the Value of Compensation for Participation in a Web-Based Survey: Randomized Controlled Trial
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Turnbull, Alison E, O'Connor, Cristi L, Lau, Bryan, Halpern, Scott D, and Needham, Dale M
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundSurvey response rates among physicians are declining, and determining an appropriate level of compensation to motivate participation poses a major challenge. ObjectiveTo estimate the effect of permitting intensive care physicians to select their preferred level of compensation for completing a short Web-based survey on physician (1) response rate, (2) survey completion rate, (3) time to response, and (4) time spent completing the survey. MethodsA total of 1850 US intensivists from an existing database were randomized to receive a survey invitation email with or without an Amazon.com incentive available to the first 100 respondents. The incentive could be instantly redeemed for an amount chosen by the respondent, up to a maximum of US $50. ResultsThe overall response rate was 35.90% (630/1755). Among the 35.4% (111/314) of eligible participants choosing the incentive, 80.2% (89/111) selected the maximum value. Among intensivists offered an incentive, the response was 6.0% higher (95% CI 1.5-10.5, P=.01), survey completion was marginally greater (807/859, 94.0% vs 892/991, 90.0%; P=.06), and the median number of days to survey response was shorter (0.8, interquartile range [IQR] 0.2-14.4 vs 6.6, IQR 0.3-22.3; P=.001), with no difference in time spent completing the survey. ConclusionsPermitting intensive care physicians to determine compensation level for completing a short Web-based survey modestly increased response rate and substantially decreased response time without decreasing the time spent on survey completion.
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- 2015
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14. Cold shock domain–containing protein E1 is a posttranscriptional regulator of the LDL receptor
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Smith, Geoffrey A, Padmanabhan, Arun, Lau, Bryan H, Pampana, Akhil, Li, Li, Lee, Clara Y, Pelonero, Angelo, Nishino, Tomohiro, Sadagopan, Nandhini, Xia, Vivian Q, Jain, Rajan, Natarajan, Pradeep, Wu, Roland S, Black, Brian L, Srivastava, Deepak, Shokat, Kevan M, and Chorba, John S
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Medical Biotechnology ,Biomedical and Clinical Sciences ,Atherosclerosis ,Heart Disease ,Digestive Diseases ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Genetics ,Biotechnology ,Aetiology ,2.1 Biological and endogenous factors ,Animals ,Cold-Shock Response ,DNA-Binding Proteins ,Humans ,Mice ,Proprotein Convertase 9 ,RNA ,Messenger ,RNA-Binding Proteins ,Receptors ,LDL ,Transcription ,Genetic ,Biological Sciences ,Medical and Health Sciences ,Medical biotechnology ,Biomedical engineering - Abstract
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to identify regulators of the LDLR beyond the targets of current therapies and known causes of familial hypercholesterolemia. We found that cold shock domain-containing protein E1 (CSDE1) enhanced hepatic LDLR messenger RNA (mRNA) decay via its 3' untranslated region and regulated atherogenic lipoproteins in vivo. Using parallel phenotypic genome-wide CRISPR interference screens in a tissue culture model, we identified 40 specific regulators of the LDLR that were not previously identified by observational human genetic studies. Among these, we demonstrated that, in HepG2 cells, CSDE1 regulated the LDLR at least as strongly as statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. In addition, we showed that hepatic gene silencing of Csde1 treated diet-induced dyslipidemia in mice to a similar degree as Pcsk9 silencing. These results suggest the therapeutic potential of targeting CSDE1 to manipulate the posttranscriptional regulation of the LDLR mRNA for the prevention of cardiovascular disease. Our approach of modeling a clinically relevant phenotype in a forward genetic screen, followed by mechanistic pharmacologic dissection and in vivo validation, may serve as a generalizable template for the identification of therapeutic targets in other human disease states.
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- 2022
15. Determinants of receipt of prostate cancer screening among men living with HIV enrolled in an urban HIV Clinic in the United States over the period of 2000–2020
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Pirsl, Filip, Keruly, Jeanne C., Moore, Richard D., Lau, Bryan, and Joshu, Corinne E.
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- 2024
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16. Early Outpatient Treatment for Covid-19 with Convalescent Plasma
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Sullivan, David J, Gebo, Kelly A, Shoham, Shmuel, Bloch, Evan M, Lau, Bryan, Shenoy, Aarthi G, Mosnaim, Giselle S, Gniadek, Thomas J, Fukuta, Yuriko, Patel, Bela, Heath, Sonya L, Levine, Adam C, Meisenberg, Barry R, Spivak, Emily S, Anjan, Shweta, Huaman, Moises A, Blair, Janis E, Currier, Judith S, Paxton, James H, Gerber, Jonathan M, Petrini, Joann R, Broderick, Patrick B, Rausch, William, Cordisco, Marie-Elena, Hammel, Jean, Greenblatt, Benjamin, Cluzet, Valerie C, Cruser, Daniel, Oei, Kevin, Abinante, Matthew, Hammitt, Laura L, Sutcliffe, Catherine G, Forthal, Donald N, Zand, Martin S, Cachay, Edward R, Raval, Jay S, Kassaye, Seble G, Foster, E Colin, Roth, Michael, Marshall, Christi E, Yarava, Anusha, Lane, Karen, McBee, Nichol A, Gawad, Amy L, Karlen, Nicky, Singh, Atika, Ford, Daniel E, Jabs, Douglas A, Appel, Lawrence J, Shade, David M, Ehrhardt, Stephan, Baksh, Sheriza N, Laeyendecker, Oliver, Pekosz, Andrew, Klein, Sabra L, Casadevall, Arturo, Tobian, Aaron AR, and Hanley, Daniel F
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Clinical Trials and Supportive Activities ,Neurodegenerative ,Patient Safety ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adult ,Ambulatory Care ,COVID-19 ,Disease Progression ,Double-Blind Method ,Hospitalization ,Humans ,Immunization ,Passive ,Treatment Outcome ,United States ,COVID-19 Serotherapy ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundPolyclonal convalescent plasma may be obtained from donors who have recovered from coronavirus disease 2019 (Covid-19). The efficacy of this plasma in preventing serious complications in outpatients with recent-onset Covid-19 is uncertain.MethodsIn this multicenter, double-blind, randomized, controlled trial, we evaluated the efficacy and safety of Covid-19 convalescent plasma, as compared with control plasma, in symptomatic adults (≥18 years of age) who had tested positive for severe acute respiratory syndrome coronavirus 2, regardless of their risk factors for disease progression or vaccination status. Participants were enrolled within 8 days after symptom onset and received a transfusion within 1 day after randomization. The primary outcome was Covid-19-related hospitalization within 28 days after transfusion.ResultsParticipants were enrolled from June 3, 2020, through October 1, 2021. A total of 1225 participants underwent randomization, and 1181 received a transfusion. In the prespecified modified intention-to-treat analysis that included only participants who received a transfusion, the primary outcome occurred in 17 of 592 participants (2.9%) who received convalescent plasma and 37 of 589 participants (6.3%) who received control plasma (absolute risk reduction, 3.4 percentage points; 95% confidence interval, 1.0 to 5.8; P = 0.005), which corresponded to a relative risk reduction of 54%. Evidence of efficacy in vaccinated participants cannot be inferred from these data because 53 of the 54 participants with Covid-19 who were hospitalized were unvaccinated and 1 participant was partially vaccinated. A total of 16 grade 3 or 4 adverse events (7 in the convalescent-plasma group and 9 in the control-plasma group) occurred in participants who were not hospitalized.ConclusionsIn participants with Covid-19, most of whom were unvaccinated, the administration of convalescent plasma within 9 days after the onset of symptoms reduced the risk of disease progression leading to hospitalization. (Funded by the Department of Defense and others; CSSC-004 ClinicalTrials.gov number, NCT04373460.).
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- 2022
17. Drug and alcohol use among people living with HIV in care in the United States by geographic region
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Crane, Heidi M, Nance, Robin M, Whitney, Bridget M, Ruderman, Stephanie, Tsui, Judith I, Chander, Geetanjali, McCaul, Mary E, Lau, Bryan, Mayer, Kenneth H, Batey, D Scott, Safren, Steven A, Moore, Richard D, Eron, Joseph J, Napravnik, Sonia, Mathews, W Chris, Fredericksen, Rob J, Hahn, Andrew W, Mugavero, Michael J, Lober, William B, Saag, Michael S, Kitahata, Mari M, and Delaney, Joseph AC
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Clinical and Health Psychology ,Health Sciences ,Public Health ,Human Society ,Psychology ,Sociology ,Prevention ,Substance Misuse ,Methamphetamine ,Brain Disorders ,Alcoholism ,Alcohol Use and Health ,HIV/AIDS ,Drug Abuse (NIDA only) ,Good Health and Well Being ,Alcohol Drinking ,Analgesics ,Opioid ,Crack Cocaine ,HIV Infections ,Humans ,Practice Patterns ,Physicians' ,United States ,Drug use ,alcohol use ,marijuana ,methamphetamine ,HIV ,Public Health and Health Services ,Public health ,Clinical and health psychology - Abstract
Substance use in the U.S. varies by geographic region. Opioid prescribing practices and marijuana, heroin, and methamphetamine availability are evolving differently across regions. We examined self-reported substance use among people living with HIV (PLWH) in care at seven sites from 2017-2019 to understand current regional substance use patterns. We calculated the percentage and standardized percentage of PLWH reporting current drug use and at-risk and binge alcohol use by U.S. Census Bureau geographic region and examined associations in adjusted logistic regression analyses. Among 7,686 PLWH, marijuana use was the most prevalent drug (30%), followed by methamphetamine/crystal (8%), cocaine/crack (7%), and illicit opioids (3%). One-third reported binge alcohol use (32%). Differences in percent of current use by region were seen for marijuana (24-41%) and methamphetamine/crystal (2-15%), with more use in the West and Northeast, and binge alcohol use (26-40%). In adjusted analyses, PLWH in the Midwest were significantly less likely to use methamphetamine/crystal (aOR: 0.13;0.06-0.25) or illicit opioids (aOR:0.16;0.05-0.53), and PLWH in the Northeast were more likely to use cocaine/crack (aOR:1.59;1.16-2.17), compared to PLWH in the West. Understanding differences in substance use patterns in the current era, as policies continue to evolve, will enable more targeted interventions in clinical settings among PLWH.
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- 2021
18. Lower endoscopy, early-onset, and average-onset colon cancer among Medicaid beneficiaries with and without HIV
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Joshu, Corinne E., Calkins, Keri L., Rudolph, Jacqueline E., Xu, Xiaoqiang, Wentz, Eryka, Coburn, Sally B., Kaur, Maneet, Pirsl, Filip, Moore, Richard D., and Lau, Bryan
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- 2024
- Full Text
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19. Regional Embedding Enables High-Level Quantum Chemistry for Surface Science
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Lau, Bryan T. G., Knizia, Gerald, and Berkelbach, Timothy C.
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Condensed Matter - Materials Science ,Physics - Chemical Physics - Abstract
Compared to common density functionals, ab initio wave function methods can provide greater reliability and accuracy, which could prove useful when modeling adsorbates or defects of otherwise periodic systems. However, the breaking of translational symmetry necessitates large supercells that are often prohibitive for correlated wave function methods. As an alternative, we introduce the regional embedding approach, which enables correlated wave function treatments of only a target fragment of interest through small, fragment-localized orbital spaces constructed using a simple overlap criterion. Applications to the adsorption of water on lithium hydride, hexagonal boron nitride, and graphene substrates show that regional embedding combined with focal point corrections can provide converged CCSD(T) (coupled cluster) adsorption energies with very small fragment sizes.
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- 2020
20. Timing of Antiretroviral Therapy Initiation and Risk of Cancer Among Persons Living With Human Immunodeficiency Virus
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Silverberg, Michael J, Leyden, Wendy, Hernández-Ramírez, Raúl U, Qin, Li, Lin, Haiqun, Justice, Amy C, Hessol, Nancy A, Achenbach, Chad J, D’Souza, Gypsyamber, Engels, Eric A, Althoff, Keri N, Mayor, Angel M, Sterling, Timothy R, Kitahata, Mari M, Bosch, Ronald J, Saag, Michael S, Rabkin, Charles S, Horberg, Michael A, Gill, M John, Grover, Surbhi, Mathews, W Christopher, Li, Jun, Crane, Heidi M, Gange, Stephen J, Lau, Bryan, Moore, Richard D, Dubrow, Robert, and Neugebauer, Romain S
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Hematology ,Sexually Transmitted Infections ,HIV/AIDS ,Lymphatic Research ,Prevention ,Emerging Infectious Diseases ,Clinical Research ,Infectious Diseases ,Health Disparities ,Cancer ,Rare Diseases ,Minority Health ,Lymphoma ,Women's Health ,Infection ,Good Health and Well Being ,Acquired Immunodeficiency Syndrome ,CD4 Lymphocyte Count ,HIV ,HIV Infections ,Humans ,Neoplasms ,Sarcoma ,Kaposi ,cancer ,epidemiology ,antiretroviral therapy ,causal inference ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundPersons living with human immunodeficiency virus (HIV; PLWH) experience a high burden of cancer. It remains unknown which cancer types are reduced in PLWH with earlier initiation of antiretroviral therapy (ART).MethodsWe evaluated AIDS-free, ART-naive PLWH during 1996-2014 from 22 cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. PLWH were followed from first observed CD4 of 350-500 cells/µL (baseline) until incident cancer, death, lost-to-follow-up, or December 2014. Outcomes included 6 cancer groups and 5 individual cancers that were confirmed by chart review or cancer registry linkage. We evaluated the effect of earlier (in the first 6 months after baseline) versus deferred ART initiation on cancer risk. Marginal structural models were used with inverse probability weighting to account for time-dependent confounding and informative right-censoring, with weights informed by subject's age, sex, cohort, baseline year, race/ethnicity, HIV transmission risk, smoking, viral hepatitis, CD4, and AIDS diagnoses.ResultsProtective results for earlier ART were found for any cancer (adjusted hazard ratio [HR] 0.57; 95% confidence interval [CI], .37-.86), AIDS-defining cancers (HR 0.23; 95% CI, .11-.49), any virus-related cancer (HR 0.30; 95% CI, .16-.54), Kaposi sarcoma (HR 0.25; 95% CI, .10-.61), and non-Hodgkin lymphoma (HR 0.22; 95% CI, .06-.73). By 15 years, there was also an observed reduced risk with earlier ART for virus-related NADCs (0.6% vs 2.3%; adjusted risk difference -1.6; 95% CI, -2.8, -.5).ConclusionsEarlier ART initiation has potential to reduce the burden of virus-related cancers in PLWH but not non-AIDS-defining cancers (NADCs) without known or suspected viral etiology.
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- 2021
21. Combining Effect Estimates Across Cohorts and Sufficient Adjustment Sets for Collaborative Research
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Hamra, Ghassan B, Lesko, Catherine R, Buckley, Jessie P, Jensen, Elizabeth T, Tancredi, Daniel, Lau, Bryan, Hertz-Picciotto, Irva, and Outcomes, on behalf of program collaborators for Environmental influences on Child Health
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Epidemiology ,Statistics ,Health Sciences ,Mathematical Sciences ,Bias ,Computer Simulation ,Humans ,Logistic Models ,Probability ,Collaborative research ,Directed acyclic graph ,Simulation ,program collaborators for Environmental influences on Child Health Outcomes ,Public Health and Health Services ,Public health - Abstract
BackgroundCollaborative research often combines findings across multiple, independent studies via meta-analysis. Ideally, all study estimates that contribute to the meta-analysis will be equally unbiased. Many meta-analyses require all studies to measure the same covariates. We explored whether differing minimally sufficient sets of confounders identified by a directed acyclic graph (DAG) ensures comparability of individual study estimates. Our analysis applied four statistical estimators to multiple minimally sufficient adjustment sets identified in a single DAG.MethodsWe compared estimates obtained via linear, log-binomial, and logistic regression and inverse probability weighting, and data were simulated based on a previously published DAG.ResultsOur results show that linear, log-binomial, and inverse probability weighting estimators generally provide the same estimate of effect for different estimands that are equally sufficient to adjust confounding bias, with modest differences in random error. In contrast, logistic regression often performed poorly, with notable differences in effect estimates obtained from unique minimally sufficient adjustment sets, and larger standard errors than other estimators.ConclusionsOur findings do not support the reliance of collaborative research on logistic regression results for meta-analyses. Use of DAGs to identify potentially differing minimally sufficient adjustment sets can allow meta-analyses without requiring the exact same covariates.
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- 2021
22. Secular Trends in Breast Cancer Risk Among Women With HIV Initiating ART in North America
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Coburn, Sally B, Shiels, Meredith S, Silverberg, Michael J, Horberg, Michael A, Gill, M John, Brown, Todd T, Visvanathan, Kala, Connor, Avonne E, Napravnik, Sonia, Marcus, Julia L, Moore, Richard D, Mathews, W Chris, Mayor, Angel M, Sterling, Timothy R, Li, Jun, Rabkin, Charles S, D'Souza, Gyspyamber, Lau, Bryan, Althoff, Keri N, and AIDS, for the North American AIDS Cohort Collaboration on Research and Design of the International Epidemiology Databases to Evaluate
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Oncology and Carcinogenesis ,Prevention ,Breast Cancer ,Aging ,Sexually Transmitted Infections ,Infectious Diseases ,Women's Health ,HIV/AIDS ,Cancer ,Good Health and Well Being ,Adult ,Age Distribution ,Anti-HIV Agents ,Breast Neoplasms ,Cohort Studies ,Female ,HIV Infections ,Humans ,Incidence ,Middle Aged ,North America ,Proportional Hazards Models ,Risk Factors ,women with HIV ,breast cancer trends ,mortality ,North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiology Databases to Evaluate AIDS ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
BackgroundStudies suggest lower risk of breast cancer in women with HIV versus without HIV. These estimates may be biased by lower life expectancy and younger age distribution of women with HIV. Our analysis evaluated this bias and characterized secular trends in breast cancer among women with HIV initiating antiretroviral therapy. We hypothesized breast cancer risk would increase over time as mortality decreased.SettingWomen with HIV prescribed antiretroviral therapy in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) from 1997 through 2016.MethodsWe estimated breast cancer hazard (cause-specific hazard ratios) and cumulative incidence accounting for competing risks (subdistribution hazard ratios) to assess changes in breast cancer risk over time. This was assessed overall (1997-2016) and within/across calendar periods. Analyses were adjusted for race/ethnicity and inverse probability weighted for cohort. Cumulative incidence was graphically assessed by calendar period and race/ethnicity.ResultsWe observed 11,587 women during 1997-2016, contributing 63 incident breast cancer diagnoses and 1,353 deaths [73,445 person-years (median follow-up = 4.5 years)]. Breast cancer cumulative incidence was 3.2% for 1997-2016. We observed no secular trends in breast cancer hazard or cumulative incidence. There were annual declines in the hazard and cumulative incidence of death (cause-specific hazard ratios and subdistribution hazard ratios: 0.89, 95% confidence interval: 0.87 to 0.91) which remained within and across calendar periods.ConclusionsThese findings contradict the hypothesis of increasing breast cancer risk with declining mortality over time among women with HIV, suggesting limited impact of changing mortality on breast cancer risk. Additional inquiry is merited as survival improves among women with HIV.
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- 2021
23. Changing Patterns of Alcohol Use and Probability of Unsuppressed Viral Load Among Treated Patients with HIV Engaged in Routine Care in the United States
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Lesko, Catherine R, Nance, Robin M, Lau, Bryan, Fojo, Anthony T, Hutton, Heidi E, Delaney, Joseph AC, Crane, Heidi M, Cropsey, Karen L, Mayer, Kenneth H, Napravnik, Sonia, Geng, Elvin, Mathews, W Christopher, McCaul, Mary E, and Chander, Geetanjali
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Public Health ,Health Sciences ,Pediatric ,Underage Drinking ,Women's Health ,Alcoholism ,Alcohol Use and Health ,Infectious Diseases ,Substance Misuse ,HIV/AIDS ,Sexually Transmitted Infections ,Minority Health ,Health Disparities ,Behavioral and Social Science ,Good Health and Well Being ,Adult ,Alcohol Drinking ,HIV Infections ,Humans ,Medication Adherence ,Probability ,United States ,Viral Load ,Alcohol drinking ,Drinking behavior ,HIV infections ,Prospective studies ,Patient reported outcome measures ,Viral load ,CNICS ,Public Health and Health Services ,Social Work ,Public health - Abstract
We examined HIV viral load non-suppression ([Formula: see text] 200 copies/mL) subsequent to person-periods (3-18 months) bookended by two self-reports of alcohol use on a standardized patient reported outcome assessment among adults in routine HIV care. We examined the relative risk (RR) of non-suppression associated with increases and decreases in alcohol use (relative to stable use), stratified by use at the start of the person-period. Increases in drinking from abstinence were associated with higher risk of viral non-suppression (low-risk without binge: RR 1.16, 95% CI 1.03, 1.32; low-risk with binge: RR 1.35, 95% CI 1.11, 1.63; high-risk: RR 1.89, 95% CI 1.16, 3.08). Decreases in drinking from high-risk drinking were weakly, and not statistically significantly associated with lower risk of viral non-suppression. Other changes in alcohol use were not associated with viral load non-suppression. Most changes in alcohol consumption among people using alcohol at baseline were not strongly associated with viral non-suppression.
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- 2021
24. Alcohol use and the longitudinal HIV care continuum for people with HIV who enrolled in care between 2011 and 2019
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Lesko, Catherine R., Gnang, Jeanine S., Fojo, Anthony T., Hutton, Heidi E., McCaul, Mary E., Delaney, Joseph A., Cachay, Edward R., Mayer, Kenneth H., Crane, Heidi M., Batey, D. Scott, Napravnik, Sonia, Christopoulos, Katerina A., Lau, Bryan, and Chander, Geetanjali
- Published
- 2023
- Full Text
- View/download PDF
25. Receipt of prostate-specific antigen test in Medicaid beneficiaries with and without HIV in 2001-2015 in 14 states
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Pirsl, Filip, primary, Calkins, Keri, additional, Rudolph, Jacqueline, additional, Wentz, Eryka, additional, Xu, Xiaoqiang, additional, Zhou, Yiyi, additional, Lau, Bryan, additional, and Joshu, Corinne, additional
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- 2024
- Full Text
- View/download PDF
26. Unveiling inequities in representation: Racial disparities in supportive care breast cancer clinical trial enrollment.
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Reyes, Kevin R, primary, Lau, Bryan Hill-Fung, additional, Tang, Felicia, additional, Gardner, Bianca, additional, Cui, Kathleen, additional, Trejo, Evelin, additional, and Velazquez Manana, Ana I., additional
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- 2024
- Full Text
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27. Respondent-driven sampling is more efficient than facility-based strategies at identifying undiagnosed people who inject drugs living with HIV in India
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McFall, Allison M., Solomon, Sunil S., Lau, Bryan, Latkin, Carl, Srikrishnan, Aylur K., Anand, Santhanam, Vasudevan, Canjeevaram K., Kumar, Muniratnam Suresh, Lucas, Gregory M., and H. Mehta, Shruti
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- 2023
- Full Text
- View/download PDF
28. The temporal relationship of alcohol use and subsequent self-reported health status among people with HIV
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Pytell, Jarratt D., Li, Ximin, Thompson, Carol, Lesko, Catherine R., McCaul, Mary E., Hutton, Heidi, Batey, D. Scott, Cachay, Edward, Mayer, Kenneth H., Napravnik, Sonia, Christopoulos, Katerina, Yang, Cui, Crane, Heidi M., Chander, Geetanjali, and Lau, Bryan
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- 2023
- Full Text
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29. Quantum plasmons and intraband excitons in doped nanoparticles: Failure of the Tamm-Dancoff approximation and importance of electron-hole attraction
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Lau, Bryan T. G. and Berkelbach, Timothy C.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Chemical Physics - Abstract
We use excited-state quantum chemistry techniques to investigate the intraband absorption of doped semiconductor nanoparticles as a function of doping density, nanoparticle radius, and material properties. The excess electrons are modeled as interacting particles confined in a sphere. We compare the predictions of various single-excitation theories, including time-dependent Hartree-Fock, the random-phase approximation, and configuration interaction with single excitations. We find that time-dependent Hartree-Fock most accurately describes the character of the excitation, as compared to equation-of-motion coupled-cluster theory with single and double excitations. The excitation evolves from confinement-dominated, to excitonic, to plasmonic with increasing number of electrons at fixed density, and the threshold number of electrons to produce a plasmon increases with density due to quantum confinement. Exchange integrals (attractive electron-hole interactions) are essential to properly describe excitons, and de-excitations (i.e.~avoidance of the Tamm-Dancoff approximation) are essential to properly describe plasmons. We propose a schematic model whose analytic solutions closely reproduce our numerical calculations. Our results are in good agreement with experimental spectra of doped ZnO nanoparticles at a doping density of $1.4\times 10^{20}$ cm$^{-3}$., Comment: 10 pages, 5 figures
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- 2019
30. CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor
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Smith, Geoffrey A, Padmanabhan, Arun, Lau, Bryan H, Pampana, Akhil, Li, Li, Lee, Y Clara, Pelonero, Angelo, Nishino, Tomohiro, Sadagopan, Nandhini, Jain, Rajan, Natarajan, Pradeep, Wu, Roland S, Black, Brian L, Srivastava, Deepak, Shokat, Kevan M, and Chorba, John S
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Genetics ,Biological Sciences ,Heart Disease ,Digestive Diseases ,Heart Disease - Coronary Heart Disease ,Biotechnology ,Atherosclerosis ,Human Genome ,Cardiovascular ,Aetiology ,Underpinning research ,1.1 Normal biological development and functioning ,2.1 Biological and endogenous factors ,Good Health and Well Being - Abstract
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to identify regulators of the LDLR beyond the targets of current clinical therapies and known causes of familial hypercholesterolemia. We show that Cold Shock Domain-Containing Protein E1 (CSDE1) enhances hepatic LDLR mRNA decay via its 3’ untranslated region to regulate atherogenic lipoproteins in vivo . Using parallel phenotypic genome-wide CRISPR interference screens, we found 40 specific regulators of the LDLR left unidentified by observational human genetics. Among these, we show that CSDE1 regulates the LDLR at least as strongly as the mechanistically distinct pathways exploited by the best available clinical therapies: statins and PCSK9 inhibitors. Additionally, we show that hepatic gene silencing of Csde1 treats diet-induced dyslipidemia in mice better than that of Pcsk9 . Our results reveal the therapeutic potential of manipulating a newly identified key factor in the post-transcriptional regulation of the LDLR mRNA for the prevention of cardiovascular disease. We anticipate that our approach of modelling a clinically relevant phenotype in a forward genetic screen, followed by mechanistic pharmacologic dissection and in vivo validation, will serve as a generalizable template for the identification of therapeutic targets in other human disease states. One Sentence Summary A genome-wide CRISPR screen identifies CSDE1 as a key regulator of hepatic LDLR mRNA decay in vivo , making it a promising target for heart disease. Graphical Abstract
- Published
- 2020
31. Physical Health and Mental Fatigue Disability Associated with Long COVID: Baseline Results from a US Nationwide Cohort
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Lau, Bryan, Wentz, Eryka, Ni, Zhanmo, Yenokyan, Karine, Vergara, Candelaria, Mehta, Shruti H., and Duggal, Priya
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- 2023
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32. Alcohol consumption upon direct-acting antiviral therapy for hepatitis C among persons with human immunodeficiency virus in the United States
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Chen, Po-Hung, Yenokyan, Karine, Fojo, Anthony T., Hutton, Heidi E., Lesko, Catherine R., McCaul, Mary E., Yang, Cui, Cachay, Edward R., Crane, Heidi M., Jacobson, Jeffrey M., Kim, H. Nina, Kitahata, Mari M., Mayer, Kenneth H., Moore, Richard D., Napravnik, Sonia, Saag, Michael, Lau, Bryan, and Chander, Geetanjali
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- 2022
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33. COVID-19 and the HIV continuum in people living with HIV enrolled in Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) cohorts
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Lesko, Catherine R., Keruly, Jeanne C., Moore, Richard D., Shen, Nicola M., Pytell, Jarratt D., Lau, Bryan, Fojo, Anthony T., Mehta, Shruti H., Kipke, Michele, Baum, Marianna K., Shoptaw, Steven, Gorbach, Pamina M., Mustanski, Brian, Javanbakht, Marjan, Siminski, Suzanne, and Chander, Geetanjali
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- 2022
- Full Text
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34. The relationship of alcohol and other drug use during the COVID-19 pandemic among people with or at risk of HIV; A cross-sectional survey of people enrolled in Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) cohorts
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Pytell, Jarratt D., Shen, Nicola M., Keruly, Jeanne C., Lesko, Catherine R., Lau, Bryan, Fojo, Anthony T., Baum, Marianna K., Gorbach, Pamina M., Javanbakht, Marjan, Kipke, Michele, Kirk, Gregory D., Mustanski, Brian, Shoptaw, Steven, Siminski, Susanne, Moore, Richard D., and Chander, Geetanjali
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- 2022
- Full Text
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35. Incidence of prostate cancer in Medicaid beneficiaries with and without HIV in 2001-2015 in 14 states
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Pirsl, Filip, primary, Calkins, Keri, additional, Rudolph, Jacqueline E, additional, Wentz, Eryka, additional, Xu, Xiaoqiang, additional, Lau, Bryan, additional, and Joshu, Corinne E., additional
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- 2024
- Full Text
- View/download PDF
36. Retention in care and antiretroviral therapy adherence among Medicaid beneficiaries with HIV, 2001-2015
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Rudolph, Jacqueline E, primary, Calkins, Keri L, additional, Zhang, Xueer, additional, Zhou, Yiyi, additional, Xu, Xiaoqiang, additional, Wentz, Eryka, additional, Joshu, Corinne E, additional, and Lau, Bryan, additional
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- 2024
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37. Incidence of colon cancer among Medicaid beneficiaries with and without HIV under comparable colorectal cancer screening patterns
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Rudolph, Jacqueline E, primary, Calkins, Keri, additional, Zhang, Xueer, additional, Zhou, Yiyi, additional, Pirsl, Filip, additional, Xu, Xiaoqiang, additional, Saylor, Eryka, additional, Lau, Bryan, additional, and Joshu, Corinne E, additional
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- 2024
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38. Cohort profile: the Johns Hopkins COVID Long Study (JHCLS), a United States Nationwide Prospective Cohort Study
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Wentz, Eryka, primary, Ni, Zhanmo, additional, Yenokyan, Karine, additional, Vergara, Candelaria, additional, Pahwa, Jessica, additional, Kammerling, Thea, additional, Xiao, Pu, additional, Duggal, Priya, additional, Lau, Bryan, additional, and Mehta, Shruti H, additional
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- 2024
- Full Text
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39. Meta-analysis under imbalance in measurement of confounders in cohort studies using only summary-level data
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Ray, Debashree, Muñoz, Alvaro, Zhang, Mingyu, Li, Xiuhong, Chatterjee, Nilanjan, Jacobson, Lisa P., and Lau, Bryan
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- 2022
- Full Text
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40. Alcohol Use Patterns and Subsequent Sexual Behaviors Among Women, Men who have Sex with Men and Men who have Sex with Women Engaged in Routine HIV Care in the United States
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Hutton, Heidi E, Lesko, Catherine R, Li, Ximin, Thompson, Carol B, Lau, Bryan, Napravnik, Sonia, Mayer, Kenneth H, Mathews, W Christopher, McCaul, Mary E, Crane, Heidi M, Fredericksen, Rob J, Cropsey, Karen L, Saag, Michael, Christopoulos, Katerina, and Chander, Geetanjali
- Subjects
Public Health ,Health Sciences ,Behavioral and Social Science ,HIV/AIDS ,Infectious Diseases ,Substance Misuse ,Prevention ,Sexually Transmitted Infections ,Alcoholism ,Alcohol Use and Health ,Sexual and Gender Minorities (SGM/LGBT*) ,Clinical Research ,Prevention of disease and conditions ,and promotion of well-being ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Oral and gastrointestinal ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Alcohol Drinking ,Cross-Sectional Studies ,Female ,HIV Infections ,Humans ,Male ,Middle Aged ,Prevalence ,Risk-Taking ,Sexual Behavior ,United States ,Unsafe Sex ,HIV ,Alcohol use ,Sexual risk behaviors ,Hazardous drinking ,Binge drinking ,Women ,Men who have sex with men ,MSM ,Men who have sex with women ,MSW ,Public Health and Health Services ,Social Work ,Public health - Abstract
Among people with HIV, alcohol use is associated with increased prevalence of sexual transmission behaviors. We examined associations between alcohol use in the prior year and sexual behaviors approximately six months later among 1857 women, 6752 men who have sex with men (MSM) and 2685 men who have sex with women (MSW). Any alcohol use was associated with increased risk of unsafe vaginal sex among women; anal sex and =>2 anal sex partners among MSM; and anal sex, =>2 anal or vaginal sex partners, and unsafe vaginal sex among MSW. In particular, among women >7 alcoholic drinks/week and among MSW =>5 alcoholic drinks/drinking day increased the likelihood of certain subsequent sexual behaviors. For all groups, especially women, the risk of sex under the influence of drugs/alcohol markedly increased with increases in quantity and frequency of alcohol consumption. These different patterns of drinking and sexual behaviors indicate the importance of tailored counseling messages to women, MSM and MSW.
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- 2019
41. Do Symptoms of Depression Interact with Substance Use to Affect HIV Continuum of Care Outcomes?
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Fojo, Anthony T, Lesko, Catherine R, Calkins, Keri L, Moore, Richard D, McCaul, Mary E, Hutton, Heidi E, Mathews, William C, Crane, Heidi, Christopoulos, Katerina, Cropsey, Karen, Mugavero, Michael J, Mayer, Kenneth, Pence, Brian W, Lau, Bryan, and Chander, Geetanjali
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Public Health ,Health Sciences ,Mental Health ,Depression ,Behavioral and Social Science ,Brain Disorders ,Alcoholism ,Alcohol Use and Health ,Clinical Research ,HIV/AIDS ,Health Services ,Substance Misuse ,Mental health ,Good Health and Well Being ,Adult ,Aged ,Alcohol Drinking ,Alcoholism ,Anti-HIV Agents ,Continuity of Patient Care ,Female ,HIV ,HIV Infections ,Humans ,Male ,Middle Aged ,Patient Compliance ,Substance-Related Disorders ,Treatment Outcome ,Alcohol ,Illicit drug use ,Viral suppression ,Public Health and Health Services ,Social Work ,Public health - Abstract
Few studies examine how depression and substance use interact to affect HIV control. In 14,380 persons with HIV (PWH), we used logistic regression and generalized estimating equations to evaluate how symptoms of depression interact with alcohol, cocaine, opioid, and methamphetamine use to affect subsequent retention in care, maintaining an active prescription for ART, and consistent virologic suppression. Among PWH with no or mild depressive symptoms, heavy alcohol use had no association with virologic suppression (OR 1.00 [0.95-1.06]); among those with moderate or severe symptoms, it was associated with reduced viral suppression (OR 0.80 [0.74-0.87]). We found no interactions with heavy alcohol use on retention in care or maintaining ART prescription or with other substances for any outcome. These results highlight the importance of treating moderate or severe depression in PWH, especially with comorbid heavy alcohol use, and support multifaceted interventions targeting alcohol use and depression.
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- 2019
42. HIV Viral Suppression Trends Over Time Among HIV-Infected Patients Receiving Care in the United States, 1997 to 2015: A Cohort Study.
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Nance, Robin M, Delaney, JA Chris, Simoni, Jane M, Wilson, Ira B, Mayer, Kenneth H, Whitney, Bridget M, Aunon, Frances M, Safren, Steven A, Mugavero, Michael J, Mathews, W Christopher, Christopoulos, Katerina A, Eron, Joseph J, Napravnik, Sonia, Moore, Richard D, Rodriguez, Benigno, Lau, Bryan, Fredericksen, Rob J, Saag, Michael S, Kitahata, Mari M, and Crane, Heidi M
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Clinical Research ,HIV/AIDS ,Prevention ,Infectious Diseases ,Behavioral and Social Science ,Infection ,Good Health and Well Being ,Adult ,Age Factors ,Anti-HIV Agents ,Depression ,Female ,HIV Infections ,HIV Integrase Inhibitors ,Humans ,Longitudinal Studies ,Male ,Medication Adherence ,Middle Aged ,Race Factors ,Substance-Related Disorders ,United States ,Viral Load ,Clinical Sciences ,Public Health and Health Services - Abstract
BackgroundBecause HIV viral suppression is essential for optimal outcomes and prevention efforts, understanding trends and predictors is imperative to inform public health policy.ObjectiveTo evaluate viral suppression trends in people living with HIV (PLWH), including the relationship of associated factors, such as demographic characteristics and integrase strand transfer inhibitor (ISTI) use.DesignLongitudinal observational cohort study.Setting8 HIV clinics across the United States.ParticipantsPLWH receiving clinical care.MeasurementsTo understand trends in viral suppression (≤400 copies/mL), annual viral suppression rates from 1997 to 2015 were determined. Analyses were repeated with tests limited to 1 random test per person per year and using inverse probability of censoring weights to address loss to follow-up. Joint longitudinal and survival models and linear mixed models of PLWH receiving antiretroviral therapy (ART) were used to examine associations between viral suppression or continuous viral load (VL) levels and demographic factors, substance use, adherence, and ISTI use.ResultsViral suppression increased from 32% in 1997 to 86% in 2015 on the basis of all tests among 31 930 PLWH. In adjusted analyses, being older (odds ratio [OR], 0.76 per decade [95% CI, 0.74 to 0.78]) and using an ISTI-based regimen (OR, 0.54 [CI, 0.51 to 0.57]) were associated with lower odds of having a detectable VL, and black race was associated with higher odds (OR, 1.68 [CI, 1.57 to 1.80]) (P < 0.001 for each). Similar patterns were seen with continuous VL levels; when analyses were limited to 2010 to 2015; and with adjustment for adherence, substance use, or depression.LimitationResults are limited to PLWH receiving clinical care.ConclusionHIV viral suppression rates have improved dramatically across the United States, which is likely partially attributable to improved ART, including ISTI-based regimens. However, disparities among younger and black PLWH merit attention.Primary funding sourceNational Institutes of Health.
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- 2018
43. Decreased Alcohol Consumption in an Implementation Study of Computerized Brief Intervention among HIV Patients in Clinical Care
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McCaul, Mary E., Hutton, Heidi E., Cropsey, Karen L., Crane, Heidi M., Lesko, Catherine R., Chander, Geetanjali, Mugavero, Michael J., Kitahata, Mari M., Lau, Bryan, and Saag, Michael S.
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- 2021
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44. Characterizing multimorbidity in ALIVE: comparing single and ensemble clustering methods.
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Rudolph, Jacqueline E, Lau, Bryan, Genberg, Becky L, Sun, Jing, Kirk, Gregory D, and Mehta, Shruti H
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RESEARCH funding , *CLUSTER analysis (Statistics) , *PRIMARY health care , *PSYCHOLOGY of HIV-positive persons , *COMPARATIVE studies , *MACHINE learning , *COMORBIDITY , *ALGORITHMS - Abstract
Multimorbidity, defined as having 2 or more chronic conditions, is a growing public health concern, but research in this area is complicated by the fact that multimorbidity is a highly heterogenous outcome. Individuals in a sample may have a differing number and varied combinations of conditions. Clustering methods, such as unsupervised machine learning algorithms, may allow us to tease out the unique multimorbidity phenotypes. However, many clustering methods exist, and choosing which to use is challenging because we do not know the true underlying clusters. Here, we demonstrate the use of 3 individual algorithms (partition around medoids, hierarchical clustering, and probabilistic clustering) and a clustering ensemble approach (which pools different clustering approaches) to identify multimorbidity clusters in the AIDS Linked to the Intravenous Experience cohort study. We show how the clusters can be compared based on cluster quality, interpretability, and predictive ability. In practice, it is critical to compare the clustering results from multiple algorithms and to choose the approach that performs best in the domain(s) that aligns with plans to use the clusters in future analyses. [ABSTRACT FROM AUTHOR]
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- 2024
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45. The Patient Reported Outcomes as a Clinical Tool (PROACT) Pilot Study: What Can be Gained by Sharing Computerized Patient-Reported Mental Health and Substance Use Symptoms with Providers in HIV Care?
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Jabour, Sarah M., Chander, Geetanjali, Riekert, Kristin A., Keruly, Jeanne C., Herne, Kayla, Hutton, Heidi, Beach, Mary Catherine, Lau, Bryan, Moore, Richard D., and Monroe, Anne K.
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- 2021
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46. Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV
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Bilal, Usama, McCaul, Mary E, Crane, Heidi M, Mathews, W Christopher, Mayer, Kenneth H, Geng, Elvin, Napravnik, Sonia, Cropsey, Karen L, Mugavero, Michael J, Saag, Michael S, Hutton, Heidi, Lau, Bryan, and Chander, Geetanjali
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Biomedical and Clinical Sciences ,Clinical Sciences ,Psychology ,Clinical Research ,Digestive Diseases ,Alcoholism ,Alcohol Use and Health ,Emerging Infectious Diseases ,Prevention ,Hepatitis ,Chronic Liver Disease and Cirrhosis ,HIV/AIDS ,Liver Disease ,Infectious Diseases ,Behavioral and Social Science ,Hepatitis - C ,Drug Abuse (NIDA only) ,Substance Misuse ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Prevention of disease and conditions ,and promotion of well-being ,2.2 Factors relating to the physical environment ,Aetiology ,Cardiovascular ,Oral and gastrointestinal ,Cancer ,Infection ,Stroke ,Good Health and Well Being ,Adult ,Age Factors ,Alcohol Abstinence ,Alcohol Drinking ,Alcoholism ,Anxiety ,Depression ,Disease Progression ,Female ,HIV Infections ,Hepatitis C ,Chronic ,Humans ,Logistic Models ,Longitudinal Studies ,Male ,Marijuana Use ,Middle Aged ,Sex Factors ,Substance-Related Disorders ,United States ,HIV ,Alcoholic Beverages ,Behavior ,Statistical Models ,Neurosciences ,Substance Abuse ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
BackgroundOur aim was to describe alcohol consumption trajectories in a cohort of people living with HIV and determine clinical and sociodemographic predictors of each trajectory.MethodsThis is a prospective cohort study of 7,906 patients in the 7 Centers for AIDS Research Network of Integrated Clinical Systems sites. Alcohol consumption was categorized as none, moderate, and alcohol misuse. Predictors included age, race/ethnicity, depressive or anxiety symptoms, illicit drug use (opioids, methamphetamines, cocaine/crack), marijuana use, hepatitis C virus (HCV) infection, HIV transmission risk factor, and HIV disease progression. We estimated sex-stratified alcohol consumption trajectories and their predictors.ResultsWe found 7 trajectories of alcohol consumption in men: stable nondrinking and increased drinking (71% and 29% of initial nondrinking); stable moderate, reduced drinking, and increased alcohol misuse (59%, 21%, and 21% of initial moderate alcohol use); and stable alcohol misuse and reduced alcohol misuse (75% and 25% of initial alcohol misuse). Categories were similar in women, except lack of an increase to alcohol misuse trajectory among women that begin with moderate use. Older men and women were more likely to have stable nondrinking, while younger men were more likely to increase to or remain in alcohol misuse. Minorities, people with depressive or anxiety symptoms, HCV-infected individuals, and people who injected drugs were more likely to reduce use. Illicit drug use was associated with a reduction in overall drinking, while marijuana use was associated with stable moderate drinking or misuse.ConclusionsLongitudinal trajectories of increasing alcohol use and stable misuse highlight the need to integrate routine screening and alcohol misuse interventions into HIV primary care.
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- 2018
47. Evaluating the Population Impact on Racial/Ethnic Disparities in HIV in Adulthood of Intervening on Specific Targets: A Conceptual and Methodological Framework
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Howe, Chanelle J, Dulin-Keita, Akilah, Cole, Stephen R, Hogan, Joseph W, Lau, Bryan, Moore, Richard D, Mathews, W Christopher, Crane, Heidi M, Drozd, Daniel R, Geng, Elvin, Boswell, Stephen L, Napravnik, Sonia, Eron, Joseph J, Mugavero, Michael J, and Systems, for the CFAR Network of Integrated Clinical
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Epidemiology ,Health Sciences ,Sexually Transmitted Infections ,Clinical Research ,Behavioral and Social Science ,Prevention ,Minority Health ,Infectious Diseases ,HIV/AIDS ,Good Health and Well Being ,Adult ,Anti-HIV Agents ,Ethnicity ,Female ,HIV ,HIV Infections ,Health Status Disparities ,Healthcare Disparities ,Humans ,Male ,Observational Studies as Topic ,Racial Groups ,United States ,health status disparities ,CFAR Network of Integrated Clinical Systems ,Mathematical Sciences ,Medical and Health Sciences - Abstract
Reducing racial/ethnic disparities in human immunodeficiency virus (HIV) disease is a high priority. Reductions in HIV racial/ethnic disparities can potentially be achieved by intervening on important intermediate factors. The potential population impact of intervening on intermediates can be evaluated using observational data when certain conditions are met. However, using standard stratification-based approaches commonly employed in the observational HIV literature to estimate the potential population impact in this setting may yield results that do not accurately estimate quantities of interest. Here we describe a useful conceptual and methodological framework for using observational data to appropriately evaluate the impact on HIV racial/ethnic disparities of interventions. This framework reframes relevant scientific questions in terms of a controlled direct effect and estimates a corresponding proportion eliminated. We review methods and conditions sufficient for accurate estimation within the proposed framework. We use the framework to analyze data on 2,329 participants in the CFAR [Centers for AIDS Research] Network of Integrated Clinical Systems (2008-2014) to evaluate the potential impact of universal prescription of and ≥95% adherence to antiretroviral therapy on racial disparities in HIV virological suppression. We encourage the use of the described framework to appropriately evaluate the potential impact of targeted interventions in addressing HIV racial/ethnic disparities using observational data.
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- 2018
48. Estimating multiple time‐fixed treatment effects using a semi‐Bayes semiparametric marginal structural Cox proportional hazards regression model
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Cole, Stephen R, Edwards, Jessie K, Westreich, Daniel, Lesko, Catherine R, Lau, Bryan, Mugavero, Michael J, Mathews, W Christopher, Eron, Joseph J, Greenland, Sander, and Investigators, for the CNICS
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Mathematical Sciences ,Statistics ,Anti-HIV Agents ,Bayes Theorem ,Biometry ,HIV Infections ,Humans ,Models ,Statistical ,Proportional Hazards Models ,Regression Analysis ,bias ,causal inference ,cohort study ,semi-Bayes ,semiparametric ,survival analysis ,CNICS Investigators ,Statistics & Probability - Abstract
Marginal structural models for time-fixed treatments fit using inverse-probability weighted estimating equations are increasingly popular. Nonetheless, the resulting effect estimates are subject to finite-sample bias when data are sparse, as is typical for large-sample procedures. Here we propose a semi-Bayes estimation approach which penalizes or shrinks the estimated model parameters to improve finite-sample performance. This approach uses simple symmetric data-augmentation priors. Limited simulation experiments indicate that the proposed approach reduces finite-sample bias and improves confidence-interval coverage when the true values lie within the central "hill" of the prior distribution. We illustrate the approach with data from a nonexperimental study of HIV treatments.
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- 2018
49. Computer delivered intervention for alcohol and sexual risk reduction among women attending an urban sexually transmitted infection clinic: A randomized controlled trial
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Chander, Geetanjali, Hutton, Heidi E., Xu, Xiaoqiang, Canan, Chelsea E., Gaver, Jennifer, Finkelstein, Joseph, Lesko, Catherine R., McCaul, Mary E., and Lau, Bryan
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- 2021
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50. Optical Properties of Defects in Solids via Quantum Embedding with Good Active Space Orbitals
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Lau, Bryan T. G., primary, Busemeyer, Brian, additional, and Berkelbach, Timothy C., additional
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- 2024
- Full Text
- View/download PDF
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