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24. sj-pdf-1-sri-10.1177_1553350621991224 ��� Supplemental Material for Learning Laparoscopic Surgery Skills With a 4K Ultra-High Definition 2D vs a Three-Dimensional HD Laparoscopic System: Results From a Prospective Randomized Trial

Author

Thomaschewski, Michael, J��rgens, Thorsten, Keck, Tobias, Laubert, Tilman, and Benecke, Claudia

Subjects
FOS: Materials engineering, FOS: Other engineering and technologies, FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, 91299 Materials Engineering not elsewhere classified, FOS: Health sciences, 110314 Orthopaedics, 99999 Engineering not elsewhere classified
Abstract

Supplemental Material, sj-pdf-1-sri-10.1177_1553350621991224 for Learning Laparoscopic Surgery Skills With a 4K Ultra-High Definition 2D vs a Three-Dimensional HD Laparoscopic System: Results From a Prospective Randomized Trial by Michael Thomaschewski, Thorsten J��rgens, Tobias Keck, Tilman Laubert and Claudia Benecke in Surgical Innovation

Published
2021
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25. Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease

Author

Zheng, Tenghao Ellinghaus, David Juzenas, Simonas Cossais, Francois Burmeister, Greta Mayr, Gabriele Jorgensen, Isabella Friis Teder-Laving, Maris Skogholt, Anne Heidi and Chen, Sisi Strege, Peter R. Ito, Go Banasik, Karina and Becker, Thomas Bokelmann, Frank Brunak, Soren Buch, Stephan and Clausnitzer, Hartmut Datz, Christian Degenhardt, Frauke and Doniec, Marek Erikstrup, Christian Esko, Tonu Forster, Michael Frey, Norbert Fritsche, Lars G. Gabrielsen, Maiken Elvestad Grassle, Tobias Gsur, Andrea Gross, Justus and Hampe, Jochen Hendricks, Alexander Hinz, Sebastian Hveem, Kristian Jongen, Johannes Junker, Ralf Karlsen, Tom Hemming and Hemmrich-Stanisak, Georg Kruis, Wolfgang Kupcinskas, Juozas and Laubert, Tilman Rosenstiel, Philip C. Roecken, Christoph and Laudes, Matthias Leendertz, Fabian H. Lieb, Wolfgang and Limperger, Verena Margetis, Nikolaos Matz-Rensing, Kerstin and Nemeth, Christopher Georg Ness-Jensen, Eivind Nowak-Gottl, Ulrike Pandit, Anita Pedersen, Ole Birger Peleikis, Hans Gunter Peuker, Kenneth Rodriguez, Cristina Leal Ruehlemann, Malte Christoph Schniewind, Bodo Schulzky, Martin and Skieceviciene, Jurgita Tepel, Jurgen Thomas, Laurent and Uellendahl-Werth, Florian Ullum, Henrik Vogel, Ilka Volzke, Henry von Fersen, Lorenzo von Schonfels, Witigo Vanderwerff, Brett Wilking, Julia Wittig, Michael Zeissig, Sebastian and Zobel, Myrko Zawistowski, Matthew Vacic, Vladimir Sazonova, Olga Noblin, Elizabeth S. Farrugia, Gianrico Beyder, Arthur and Wedel, Thilo Kahlke, Volker Schafmayer, Clemens D'Amato, Mauro Franke, Andre DBDS Consortium The 23andMe Res Team

Subjects
inorganic chemicals, integumentary system, polycyclic compounds, heterocyclic compounds
Abstract

Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study (GWAS) meta-analysis to identify genetic risk factors for HEM to date. Design We conducted a GWAS meta-analysis of 218 920 patients with HEM and 725 213 controls of European ancestry. Using GWAS summary statistics, we performed multiple genetic correlation analyses between HEM and other traits as well as calculated HEM polygenic risk scores (PRS) and evaluated their translational potential in independent datasets. Using functional annotation of GWAS results, we identified HEM candidate genes, which differential expression and coexpression in HEM tissues were evaluated employing RNA-seq analyses. The localisation of expressed proteins at selected loci was investigated by immunohistochemistry. Results We demonstrate modest heritability and genetic correlation of HEM with several other diseases from the GI, neuroaffective and cardiovascular domains. HEM PRS validated in 180 435 individuals from independent datasets allowed the identification of those at risk and correlated with younger age of onset and recurrent surgery. We identified 102 independent HEM risk loci harbouring genes whose expression is enriched in blood vessels and GI tissues, and in pathways associated with smooth muscles, epithelial and endothelial development and morphogenesis. Network transcriptomic analyses highlighted HEM gene coexpression modules that are relevant to the development and integrity of the musculoskeletal and epidermal systems, and the organisation of the extracellular matrix. Conclusion HEM has a genetic component that predisposes to smooth muscle, epithelial and connective tissue dysfunction.

Published
2021

26. Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease

Author

Zheng, Tenghao, Ellinghaus, David, Juzenas, Simonas, Cossais, Francois, Burmeister, Greta, Mayr, Gabriele, Jorgensen, Isabella Friis, Teder-Laving, Maris, Skogholt, Anne Heidi, Chen, Sisi, Strege, Peter R., Ito, Go, Banasik, Karina, Becker, Thomas, Bokelmann, Frank, Brunak, Soren, Buch, Stephan, Clausnitzer, Hartmut, Datz, Christian, Degenhardt, Frauke, Doniec, Marek, Erikstrup, Christian, Esko, Tonu, Forster, Michael, Frey, Norbert, Fritsche, Lars G., Gabrielsen, Maiken Elvestad, Grassle, Tobias, Gsur, Andrea, Gross, Justus, Hampe, Jochen, Hendricks, Alexander, Hinz, Sebastian, Hveem, Kristian, Jongen, Johannes, Junker, Ralf, Karlsen, Tom Hemming, Hemmrich-Stanisak, Georg, Kruis, Wolfgang, Kupcinskas, Juozas, Laubert, Tilman, Rosenstiel, Philip C., Roecken, Christoph, Laudes, Matthias, Leendertz, Fabian H., Lieb, Wolfgang, Limperger, Verena, Margetis, Nikolaos, Matz-Rensing, Kerstin, Nemeth, Christopher Georg, Ness-Jensen, Eivind, Nowak-Gottl, Ulrike, Pandit, Anita, Pedersen, Ole Birger, Peleikis, Hans Gunter, Peuker, Kenneth, Rodriguez, Cristina Leal, Ruehlemann, Malte Christoph, Schniewind, Bodo, Schulzky, Martin, Skieceviciene, Jurgita, Tepel, Jurgen, Thomas, Laurent, Uellendahl-Werth, Florian, Ullum, Henrik, Vogel, Ilka, Volzke, Henry, von Fersen, Lorenzo, von Schonfels, Witigo, Vanderwerff, Brett, Wilking, Julia, Wittig, Michael, Zeissig, Sebastian, Zobel, Myrko, Zawistowski, Matthew, Vacic, Vladimir, Sazonova, Olga, Noblin, Elizabeth S., Farrugia, Gianrico, Beyder, Arthur, Wedel, Thilo, Kahlke, Volker, Schafmayer, Clemens, D'Amato, Mauro, Franke, Andre, Zheng, Tenghao, Ellinghaus, David, Juzenas, Simonas, Cossais, Francois, Burmeister, Greta, Mayr, Gabriele, Jorgensen, Isabella Friis, Teder-Laving, Maris, Skogholt, Anne Heidi, Chen, Sisi, Strege, Peter R., Ito, Go, Banasik, Karina, Becker, Thomas, Bokelmann, Frank, Brunak, Soren, Buch, Stephan, Clausnitzer, Hartmut, Datz, Christian, Degenhardt, Frauke, Doniec, Marek, Erikstrup, Christian, Esko, Tonu, Forster, Michael, Frey, Norbert, Fritsche, Lars G., Gabrielsen, Maiken Elvestad, Grassle, Tobias, Gsur, Andrea, Gross, Justus, Hampe, Jochen, Hendricks, Alexander, Hinz, Sebastian, Hveem, Kristian, Jongen, Johannes, Junker, Ralf, Karlsen, Tom Hemming, Hemmrich-Stanisak, Georg, Kruis, Wolfgang, Kupcinskas, Juozas, Laubert, Tilman, Rosenstiel, Philip C., Roecken, Christoph, Laudes, Matthias, Leendertz, Fabian H., Lieb, Wolfgang, Limperger, Verena, Margetis, Nikolaos, Matz-Rensing, Kerstin, Nemeth, Christopher Georg, Ness-Jensen, Eivind, Nowak-Gottl, Ulrike, Pandit, Anita, Pedersen, Ole Birger, Peleikis, Hans Gunter, Peuker, Kenneth, Rodriguez, Cristina Leal, Ruehlemann, Malte Christoph, Schniewind, Bodo, Schulzky, Martin, Skieceviciene, Jurgita, Tepel, Jurgen, Thomas, Laurent, Uellendahl-Werth, Florian, Ullum, Henrik, Vogel, Ilka, Volzke, Henry, von Fersen, Lorenzo, von Schonfels, Witigo, Vanderwerff, Brett, Wilking, Julia, Wittig, Michael, Zeissig, Sebastian, Zobel, Myrko, Zawistowski, Matthew, Vacic, Vladimir, Sazonova, Olga, Noblin, Elizabeth S., Farrugia, Gianrico, Beyder, Arthur, Wedel, Thilo, Kahlke, Volker, Schafmayer, Clemens, D'Amato, Mauro, and Franke, Andre

Abstract

Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study (GWAS) meta-analysis to identify genetic risk factors for HEM to date. Design We conducted a GWAS meta-analysis of 218 920 patients with HEM and 725 213 controls of European ancestry. Using GWAS summary statistics, we performed multiple genetic correlation analyses between HEM and other traits as well as calculated HEM polygenic risk scores (PRS) and evaluated their translational potential in independent datasets. Using functional annotation of GWAS results, we identified HEM candidate genes, which differential expression and coexpression in HEM tissues were evaluated employing RNA-seq analyses. The localisation of expressed proteins at selected loci was investigated by immunohistochemistry. Results We demonstrate modest heritability and genetic correlation of HEM with several other diseases from the GI, neuroaffective and cardiovascular domains. HEM PRS validated in 180 435 individuals from independent datasets allowed the identification of those at risk and correlated with younger age of onset and recurrent surgery. We identified 102 independent HEM risk loci harbouring genes whose expression is enriched in blood vessels and GI tissues, and in pathways associated with smooth muscles, epithelial and endothelial development and morphogenesis. Network transcriptomic analyses highlighted HEM gene coexpression modules that are relevant to the development and integrity of the musculoskeletal and epidermal systems, and the organisation of the extracellular matrix. Conclusion HEM has a genetic component that predisposes to smooth muscle, epithelial and connective tissue dysfunction.

Published
2021

32. Erratum to “Efficacy of goal-directed minimally invasive surgery simulation training with the Lübeck Toolbox-Curriculum prior to first operations on patients: Study protocol for a multi-centre randomized controlled validation trial (NOVICE)” [Int. J. Surg. Protoc. 21 (2020) 13–20]

Author

Thomaschewski, Michael, primary, Laubert, Tilman, additional, Zimmermann, Markus, additional, Esnaashari, Hamed, additional, Vonthein, Reinhard, additional, Keck, Tobias, additional, and Benecke, Claudia, additional

Published
2020
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33. A novel multiplex-protein array for serum diagnostics of colon cancer: a case–control study

Author

Bünger Stefanie, Haug Ulrike, Kelly Maria, Posorski Nicole, Klempt-Giessing Katja, Cartwright Andrew, Fitzgerald Stephen P, Toner Vicki, McAleer Damien, Gemoll Timo, Laubert Tilman, Büning Jürgen, Fellermann Klaus, Bruch Hans-Peter, Roblick Uwe J, Brenner Hermann, von Eggeling Ferdinand, and Habermann Jens K

Subjects
Multiplex protein array biochip, Colon cancer screening, Serum diagnostics, High-throughput seromics, IL-8, CEA, CRP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. Methods A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Results Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Conclusions Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.

Published
2012
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34. Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas

Author

Laubert Tilman, Habermann Jens K, Hemmelmann Claudia, Kleemann Markus, Oevermann Elisabeth, Bouchard Ralf, Hildebrand Philipp, Jungbluth Thomas, Bürk Conny, Esnaashari Hamed, Schlöricke Erik, Hoffmann Martin, Ziegler Andreas, Bruch Hans-Peter, and Roblick Uwe J

Subjects
Colon cancer, Lymph nodes, Metastasis, Prognosis, Survival, Recurrence free survival, Regression analysis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Lymphadenectomy is performed to assess patient prognosis and to prevent metastasizing. Recently, it was questioned whether lymph node metastases were capable of metastasizing and therefore, if lymphadenectomy was still adequate. We evaluated whether the nodal status impacts on the occurrence of distant metastases by analyzing a highly selected cohort of colon cancer patients. Methods 1,395 patients underwent surgery exclusively for colon cancer at the University of Lübeck between 01/1993 and 12/2008. The following exclusion criteria were applied: synchronous metastasis, R1-resection, prior/synchronous second carcinoma, age < 50 years, positive family history, inflammatory bowel disease, FAP, HNPCC, and follow-up < 5 years. The remaining 421 patients were divided into groups with (TM+, n = 75) or without (TM-, n = 346) the occurrence of metastasis throughout a 5-year follow-up. Results Five-year survival rates for TM + and TM- were 21% and 73%, respectively (p < 0.0001). Survival rates differed significantly for N0 vs. N2, grading 2 vs. 3, UICC-I vs. -II and UICC-I vs. -III (p < 0.05). Regression analysis revealed higher age upon diagnosis, increasing N- and increasing T-category to significantly impact on recurrence free survival while increasing N-and T-category were significant parameters for the risk to develop metastases within 5-years after surgery (HR 1.97 and 1.78; p < 0.0001). Conclusions Besides a higher T-category, a positive N-stage independently implies a higher probability to develop distant metastases and correlates with poor survival. Our data thus show a prognostic relevance of lymphadenectomy which should therefore be retained until conclusive studies suggest the unimportance of lmyphadenectomy.

Published
2012
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39. Prospektive Studie zum Effekt der 3D-Darstellung auf die Lernkurve der minimalinvasiven Chirurgie an einem hoch standardisierten Simulator (Lübecker Toolbox)

Author

Laubert, Tilman, Jürgens, Thorsten, Höfer, Anna Catharina, Esnaashari, Hamed, Auerswald, Paul, Scheppan, Diana, Simon, Ronja, Bulmann, Romy, Benecke, Claudia, and Keck, Tobias

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: In der minimalinvasiven Chirurgie (MIC) wird das durch die endoskopische Optik gewonnene Bild typischerweise zweidimensional (2D) dargestellt. Der Verlust der Tiefeninformation führt zu einer beeinträchtigten Hand-Auge-Koordination und visuell-kognitive Kompensationsmechanismen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2016

42. Entwicklung von Zielvorgaben für ein standardisiertes MIC-Trainingscurriculum an der Lübecker Toolbox und Übertragbarkeit des Trainingseffektes

Author

Laubert, Tilman, Höfer, Anna, Auerswald, Paul, Keck, Tobias, and Esnaashari, Hamed

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Der Beginn der Lernkurve der minimalinvasiven Chirurige (MIC) ist durch Anforderungen charakterisiert, die sich sehr gut außerhalb des OPs erlernen und trainieren lassen. Standardisierte Traningscurricula, um strukturiert Basifertigkeiten der MIC zu erlernen, existieren in Europa jedoch[for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2015

44. Hohe Rate an präoperativ nicht diagnostizierten kolorektalen Neoplasien in Proktokolektomieprärparaten bei CED

Author

Laubert, Tilman, Habermann, Jens K., Sommer, Marin, Fellermann, Klaus, Büning, Jürgen, and Bruch, Hans-Peter

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Indikation zur Resektion des Kolorektums bei einer chronisch-entzündlichen Darmerkrankung (CED) kann sich aufgrund eines therapierefraktären Verlaufes, des Nachweises (prä)maligner Läsionen und aufgrund von Komplikationen ergeben. Die Patienten stehen meist[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013

46. Metastasierungsverhalten kolorektaler Karzinome - eine Matched Pair-Analyse zum Ploidiestatus

Author

Laubert, Tilman, Bente, Verena, Voulgaris, Helena, Meyer, Karl F., Bruch, Hans-Peter, Roblick, Uwe Johannes, and Habermann, Jens Karsten

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das Auftreten von distanten Metastasen limitiert die Prognose des kolorektalen Karzinoms (KRK) erheblich. Neben zahlreichen anderen Parametern korreliert der Nachweis von nukleärer Aneuploidie im Primärtumor mit einer schlechten Prognose. Inwieweit der Ploidiestatus mit dem Auftreten[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012

47. Die differente chirurgische Therapie der Mucozele als inhomogene Krankheitsentität

Author

Kleemann, Markus, Laubert, Tilman, Krockowski, Manuela, Eckmann, Christian, Bruch, Hans-Peter, and Kujath, Peter

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Mukozelen der Appendix, obwohl insgesamt recht selten, sind eine gut bekannte Krankheitsentität. Mukozelen der Appendix weisen eine große Variabilität an Klinik, diagnostischen Befunden und zu Grunde liegenden Pathologien auf. Als Ursache für die Entstehung der Erkrankung[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012

48. Laparoscopic Navigated Liver Resection: Technical Aspects and Clinical Practice in Benign Liver Tumors

Author

Kleemann, Markus, Deichmann, Steffen, Esnaashari, Hamed, Besirevic, Armin, Shahin, Osama, Bruch, Hans-Peter, and Laubert, Tilman

Subjects
Article Subject
Abstract

Laparoscopic liver resection has been performed mostly in centers with an extended expertise in both hepatobiliary and laparoscopic surgery and only in highly selected patients. In order to overcome the obstacles of this technique through improved intraoperative visualization we developed a laparoscopic navigation system (LapAssistent) to register pre-operatively reconstructed three-dimensional CT or MRI scans within the intra-operative field. After experimental development of the navigation system, we commenced with the clinical use of navigation-assisted laparoscopic liver surgery in January 2010. In this paper we report the technical aspects of the navigation system and the clinical use in one patient with a large benign adenoma. Preoperative planning data were calculated by Fraunhofer MeVis Bremen, Germany. After calibration of the system including camera, laparoscopic instruments, and the intraoperative ultrasound scanner we registered the surface of the liver. Applying the navigated ultrasound the preoperatively planned resection plane was then overlain with the patient's liver. The laparoscopic navigation system could be used under sterile conditions and it was possible to register and visualize the preoperatively planned resection plane. These first results now have to be validated and certified in a larger patient collective. A nationwide prospective multicenter study (ProNavic I) has been conducted and launched.

Published
2012
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49. Prognose des sporadischen Kolonkarzinoms - Analyse eines hoch selektierten Patientenkollektivs

Author

Laubert, Tilman, Hemmelmann, Claudia, Kleemann, Markus, Oevermann, Elisabeth, Bürk, Conny, Jungbluth, Thomas, Ziegler, Andreas, Bruch, Hans-Peter, Roblick, Uwe Johannes, and Habermann, Jens Karsten

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Prognose des kolorektalen Karzinoms hängt vom Tumorstadium und dem möglichen Auftreten von metachronen Fernmetastasen ab. Für eine genaue Analyse der Prognose ist es essentiell, diejenigen Faktoren zu berücksichtigen, die zusätzlich einen Einfluss auf die Prognose[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011

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