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4. Protected or Unprotected Fat Addition for Feedlot Lambs: Feeding Behavior, Carcass Traits, and Meat Quality

Author

Henry D. R. Alba, José E. de Freitas Júnior, Laudi C. Leite, José A. G. Azevêdo, Stefanie A. Santos, Douglas S. Pina, Luís G. A. Cirne, Carlindo S. Rodrigues, Willian P. Silva, Victor G. O. Lima, Manuela S. L. Tosto, and Gleidson G. P. de Carvalho

Subjects
calcium salt, fatty acid, lipid, ruminant nutrition, sheep, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

This study aimed to evaluate the effect of the inclusion of protected or unprotected fats in the diet of feedlot lambs on feeding behavior, productive characteristics, carcass traits, and meat quality. Forty male Dorper × Santa Inês lambs (22.27 ± 2.79 kg) were randomly assigned to treatments in a completely randomized design. The experimental treatments consisted of five diets: no added fat (NAF), whole soybeans (WSB), calcium salts of fatty acids (CSFA), soybean oil (SO), and corn germ (CG). The total intake of dry matter (DMI) (p < 0.001) and neutral detergent fiber (NDFI) (p = 0.010) were higher in the CSFA and NAF diets. Feeding behavior, morphometric measurements, physicochemical characteristics, and centesimal composition of the Longissimus lumborum muscle were similar between treatments (p > 0.05). The CSFA diet provided higher production (p < 0.05) and better-quality carcasses. The inclusion of fat sources increased the concentration of polyunsaturated fatty acids (p < 0.05). The use of calcium salts of fatty acids in feedlot lambs’ diets provides better quantitative and qualitative characteristics of the meat and carcass.

Published
2021
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10. Protected or Unprotected Fat Addition for Feedlot Lambs: Feeding Behavior, Carcass Traits, and Meat Quality

Author

Alba, Henry D. R., primary, Freitas Júnior, José E. de, additional, Leite, Laudi C., additional, Azevêdo, José A. G., additional, Santos, Stefanie A., additional, Pina, Douglas S., additional, Cirne, Luís G. A., additional, Rodrigues, Carlindo S., additional, Silva, Willian P., additional, Lima, Victor G. O., additional, Tosto, Manuela S. L., additional, and Carvalho, Gleidson G. P. de, additional

Published
2021
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14. Ruminal fatty acid outflow in dry cows fed different sources of linoleic acid: reticulum and omasum as alternative sampling sites to abomasum

Author

Freitas Júnior, José E., primary, Bettero, Vitor P., additional, Zanferari, Filipe, additional, Del Valle, Tiago A., additional, De Paiva, Pablo G., additional, Ferreira De Jesus, Elmeson, additional, Takiya, Caio S., additional, Leite, Laudi C., additional, Dias, Márcia, additional, and Rennó, Francisco P., additional

Published
2019
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15. Effects of pearl millet silage ammoniation with urea on carcass and meat quality of lambs

Author

de Carvalho, Gleidson G. P., primary, de Freitas, Poliane Meire D., additional, Santos, Edson M., additional, Araújo, Gherman G. L., additional, de Oliveira, Juliana S., additional, Rodrigues, Thomaz Cyro G. de C., additional, de Araujo, Maria Leonor G. M. L., additional, de Assis, Dallyson Yehudi C., additional, Roça, Roberto de O., additional, de Delbem, Nara Laiane C., additional, Lomele, Renata L., additional, Leite, Laudi C., additional, and Rodrigues, Carlindo S., additional

Published
2018
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17. Efficacy of computer-aided detection as a second reader for 6-9-mm lesions at CT colonography: multicenter prospective trial

Author

Regge, D, Della Monica, P, Galatola, G, Laudi, C, Zambon, A, Correale, L, Asnaghi, R, Barbaro, B, Borghi, C, Campanella, D, Cassinis, M, Ferrari, R, Ferraris, A, Hassan, C, Golfieri, R, Iafrate, F, Iussich, G, Laghi, A, Massara, R, Neri, E, Sali, L, Venturini, S, Gandini, G, Regge D, Della Monica P, Galatola G, Laudi C, Correale L, Asnaghi R, Barbaro B, Borghi C, Campanella D, Cassinis MC, Ferrari R, Ferraris A, Hassan C, Golfieri R, Iafrate F, Iussich G, Laghi A, Massara R, Neri E, Sali L, Venturini S, Gandini G., ZAMBON, ANTONELLA, Regge, D, Della Monica, P, Galatola, G, Laudi, C, Zambon, A, Correale, L, Asnaghi, R, Barbaro, B, Borghi, C, Campanella, D, Cassinis, M, Ferrari, R, Ferraris, A, Hassan, C, Golfieri, R, Iafrate, F, Iussich, G, Laghi, A, Massara, R, Neri, E, Sali, L, Venturini, S, Gandini, G, Regge D, Della Monica P, Galatola G, Laudi C, Correale L, Asnaghi R, Barbaro B, Borghi C, Campanella D, Cassinis MC, Ferrari R, Ferraris A, Hassan C, Golfieri R, Iafrate F, Iussich G, Laghi A, Massara R, Neri E, Sali L, Venturini S, Gandini G., and ZAMBON, ANTONELLA

Abstract

PURPOSE: To assess the effect of computer-aided detection (CAD) as a second reader on the sensitivity and specificity of computed tomographic (CT) colonography in detecting 6-9-mm colorectal cancer (CRC) lesions. MATERIALS AND METHODS: Individuals with clinical indications for colonoscopy--either for symptoms or as part of participating in a surveillance program or CRC screening--were prospectively enrolled at one of 10 academic centers between July 2007 and May 2009. Institutional review board approval was obtained at each clinical site, and all participants provided written informed consent. All participants underwent CT colonography and colonoscopy on the same day. Experienced readers interpreted the CT colonography images unassisted and then reviewed all colorectal lesion-like structures pinpointed by the CAD algorithm. Segmental unblinding of CT colonoscopy findings at colonoscopy was utilized. The sensitivity and specificity of unassisted and CAD-assisted reading in identifying individuals with 6-9-mm lesions were calculated and compared by means of pairwise analysis. RESULTS: A total of 618 participants (mean age, 57.9 years; 54.5% male) were included in the final analysis. Of these participants, 464 (75.1%) had no lesions 6 mm or larger, and 52 (8.4%) had 6-9-mm lesions. The sensitivity of CT colonography with unassisted reading and that with CAD-assisted reading in identifying individuals with 6-9-mm lesions was 65.4% (95% confidence interval [CI]: 50.9%, 78.0%) and 76.9% (95% CI: 63.2%, 87.5%; P = .016), respectively. No significant change in specificity was observed: The specificity of CT colonography with unassisted and that with CAD-assisted reading was 91.8% (95% CI: 88.9%, 94.1%) and 90.9% (95% CI: 88.0%, 93.4%; P = .063), respectively. Evaluation of CAD candidates required an additional 1.6 minutes (25th-75th percentile: 1.0 minute to 3.4 minutes). CONCLUSION: The addition of CAD to reading performed by experienced readers resulted in a significant b

Published
2013

18. Albumin replacement in patients with severe sepsis or septic shock

Author

Gattinoni L, Caironi P, Pesenti A, Fumagalli R, Tognoni G, Romero M, Latini R, Masson S, Vincent JL, Suter PM, Valsecchi MG, Santosuosso A, Cavana M, Ortu A, Gabini R, Perno S, Anelli A, Amoruso R, Ferraris S, Borelli M, Massei R, Riva I, Poli G, Papagni G, Bortone F, Mamprin F, Keim R, Brivio M, Colageo U, Mimii EP, Sangiorgi G, Siniscalchi A, Pierucci E, Giovannitti A, Gentile C, Pascucci F, Antonini B, Zummo U, Valsecchi R, Cerisara M, Trezzi T, Dossena A, Ribola A, Tamayo L, Zoppellari R, Volta CA, Mangani V, Fanfani E, Chelazzi C, Bartoli T, Parrini V, Oggioni R, Fedele A, Molin A, Berri C, Guarino A, Isetta M, Bonfiglio M, Tissino F, Silvestri L, Milanesi M, Sbrana G, Motta E, Iannaco I, Casadio MC, Pasetti GS, Palandini A, Cascione C, Puscio D, Cellai F, Boccalatte D, Silvestri S, Fausto CI, Lupo V, Zompanti V, Iacobone E, Gattari D, Ronzoni G, Beck E, Francesconi S, Colombo R, Raimondi F, Castelli A, De Gasperi A, Radrizzani D, Ferla LE, Giudici R, Bellato V, Bordone G, Gavazzeni V, Lesmo A, Ripamonti D, Vesconi S, Papoff A, Rossi A, Noto A, Pezzi A, Zanforlin G, Kandil H, Ballotta A, Bettini F, Vaghi GM, Rossi S, Pessina C, Casagrande D, Trivellato A, Costagli V, Moise G, Furla M, Marelli S, Caspani L, Panigada M, Bruzzone P, Isgrò S, Abbruzzese C, Tagliabue P, Solca M, Bonazzi M, Cattaneo A, Rossi N, Andreoni P, Pasetto A, Girardis M, Barbieri E, Piazza O, Zagara G, Bono M, Galzerano A, Garzilli T, Dentini N, Bindi M, Biancofiore G, Mercante WP, Disconzi MM, Todesco N, Lunardi S, Sani E, Carli M, Bracciotti G, Gori V, Braccini P, Maggio G, Braschi A, Bottazzi A, Iotti G, Nicora B, Salati G, Salsi P, Antonelli M, Pennisi MA, Bello G, Caccese R, D'Ambrosio M, Rocco M, Sanseverino M, Gatta A, Nastasi M, Corsi A, Facondini F, Franchi F, Mongelli P, Ferrario M, Carulli F, Del Curto S, Schiappacasse G, Dalpiaz C, Armani S, Verderosa I, Marzullo A, Tonetti F, De Piero ME, Livigni S, Fiore G, Cerutti A, Erbetta S, Napolitano R, Pastorelli M, Bona F, Debernardi F, Gallo M, Segala V, Parigi L, Perzolla D, Marson F, Chiarandini P, Cammarano C, Sermann G, De Lucia S, Frigerio A, Distaso F, Franco R, Bossi E, Laudi C, De Nardin M, Violo T, Lazzari F, Vestali A, Della Mora E, Polati E, Martini A, Cristallini S, Totaro C, Milan B, Dan M, Ruberti S, Danzi V., GIARRATANO, Antonino, RAINERI, Santi Maurizio, CORTEGIANI, Andrea, Caironi, P, Tognoni, G, Masson, S, Fumagalli, R, Pesenti, A, Romero, M, Fanizza, C, Caspani, L, Faenza, S, Grasselli, G, Iapichino, G, Antonelli, M, Parrini, V, Fiore, G, Latini, R, Gattinoni, L, Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, Iapichino G, Antonelli M, Parrini V, Fiore G, Latini R, Gattinoni L, Vincent JL, Suter PM, Valsecchi MG, Santosuosso A, Cavana M, Ortu A, Gabini R, Perno S, Anelli A, Amoruso R, Ferraris S, Borelli M, Massei R, Riva I, Poli G, Papagni G, Bortone F, Mamprin F, Keim R, Brivio M, Colageo U, Mimii EP, Sangiorgi G, Siniscalchi A, Pierucci E, Giovannitti A, Gentile C, Pascucci F, Antonini B, Zummo U, Valsecchi R, Cerisara M, Trezzi T, Dossena A, Ribola A, Tamayo L, Zoppellari R, Volta CA, Mangani V, Fanfani E, Chelazzi C, Bartoli T, Oggioni R, Fedele A, Molin A, Berri C, Guarino A, Isetta M, Bonfiglio M, Tissino F, Silvestri L, Milanesi M, Sbrana G, Motta E, Iannaco I, Casadio MC, Pasetti GS, Palandini A, Cascione C, Puscio D, Cellai F, Boccalatte D, Silvestri S, Fausto CI, Lupo V, Zompanti V, Iacobone E, Gattari D, Ronzoni G, Beck E, Francesconi S, Colombo R, Raimondi F, Castelli A, De Gasperi A, Radrizzani D, Ferla LE, Giudici R, Bellato V, Bordone G, Gavazzeni V, Lesmo A, Ripamonti D, Vesconi S, Papoff A, Rossi A, Noto A, Pezzi A, Zanforlin G, Kandil H, Ballotta A, Bettini F, Vaghi GM, Rossi S, Pessina C, Casagrande D, Trivellato A, Costagli V, Moise G, Furla M, Marelli S, Panigada M, Bruzzone P, Isgrò S, Abbruzzese C, Tagliabue P, Solca M, Bonazzi M, Cattaneo A, Rossi N, Andreoni P, Pasetto A, Girardis M, Barbieri E, Piazza O, Giarratano A, Raineri SM, Cortegiani A, Zagara G, Bono M, Galzerano A, Garzilli T, Dentini N, Bindi M, Biancofiore G, Mercante WP, Disconzi MM, Todesco N, Lunardi S, Sani E, Carli M, Bracciotti G, Gori V, Braccini P, Maggio G, Braschi A, Bottazzi A, Iotti G, Nicora B, Salati G, Salsi P, Pennisi MA, Bello G, Caccese R, D'Ambrosio M, Rocco M, Sanseverino M, Gatta A, Nastasi M, Corsi A, Facondini F, Franchi F, Mongelli P, Ferrario M, Carulli F, Del Curto S, Schiappacasse G, Dalpiaz C, Armani S, Verderosa I, Marzullo A, Tonetti F, De Piero ME, Livigni S, Cerutti A, Erbetta S, Napolitano R, Pastorelli M, Bona F, Debernardi F, Gallo M, Segala V, Parigi L, Perzolla D, Marson F, Chiarandini P, Cammarano C, Sermann G, De Lucia S, Frigerio A, Distaso F, Franco R, Bossi E, Laudi C, De Nardin M, Violo T, Lazzari F, Vestali A, Della Mora E, Polati E, Martini A, Cristallini S, Totaro C, Milan B, Dan M, Ruberti S, and Danzi V

Subjects
Male, medicine.medical_specialty, ALBUMIN, SEPSIS, SEVERE SEPSIS, SEPTIC SHOCK, Sepsi, Serum albumin, Settore MED/41 - Anestesiologia, Aged, Albumins, Female, Humans, Isotonic Solutions, Middle Aged, Rehydration Solutions, Sepsis, Serum Albumin, Shock, Septic, Survival Rate, Treatment Outcome, Intensive care, medicine, albumin replacement, Survival rate, Isotonic Solution, Medicine (all), SEPSIS, biology, business.industry, Septic shock, Rehydration Solution, Septic, Albumin, SEPTIC SHOCK, Organ dysfunction, Shock, General Medicine, medicine.disease, Surgery, Anesthesia, Relative risk, biology.protein, medicine.symptom, business, Human
Abstract

BACKGROUND: Although previous studies have suggested the potential advantages of albumin administration in patients with severe sepsis, its efficacy has not been fully established. METHODS: In this multicenter, open-label trial, we randomly assigned 1818 patients with severe sepsis, in 100 intensive care units (ICUs), to receive either 20% albumin and crystalloid solution or crystalloid solution alone. In the albumin group, the target serum albumin concentration was 30 g per liter or more until discharge from the ICU or 28 days after randomization. The primary outcome was death from any cause at 28 days. Secondary outcomes were death from any cause at 90 days, the number of patients with organ dysfunction and the degree of dysfunction, and length of stay in the ICU and the hospital. RESULTS: During the first 7 days, patients in the albumin group, as compared with those in the crystalloid group, had a higher mean arterial pressure (P = 0.03) and lower net fluid balance (P

Published
2014

19. Efficacy of computer-aided detection as a second reader for 6-9-mm lesions at CT colonography: multicenter prospective trial

Author

Regge, Daniele, Della Monica, P, Galatola, G, Laudi, C, Zambon, A, Correale, L, Asnaghi, R, Barbaro, B, Borghi, C, Campanella, D, Cassinis, Maria Carla, Ferrari, R, Ferraris, A, Hassan, C, Golfieri, R, Iafrate, F, Iussich, G, Laghi, A, Massara, R, Neri, E, Sali, L, Venturini, S, Gandini, Giovanni, Regge, Daniele, Della Monica, Patrizia, Galatola, Giovanni, Laudi, Cristiana, Zambon, Antonella, Asnaghi, Roberto, Correale, Loredana, Barbaro, Brunella, Borghi, Claudia, Campanella, Delia, Cassinis, Maria Carla, Ferrari, Riccardo, Ferraris, Andrea, Golfieri, Rita, Hassan, Cesare, Iafrate, Franco, Iussich, Gabriella, Laghi, Andrea, Massara, Roberto, Neri, Emanuele, Sali, Lapo, Venturini, Silvia, Gandini, Giovanni, Regge, D, Della Monica, P, Galatola, G, Laudi, C, Zambon, A, Correale, L, Asnaghi, R, Barbaro, B, Borghi, C, Campanella, D, Cassinis, M, Ferrari, R, Ferraris, A, Hassan, C, Golfieri, R, Iafrate, F, Iussich, G, Laghi, A, Massara, R, Neri, E, Sali, L, Venturini, S, and Gandini, G

Subjects
Male, Radiology, Nuclear Medicine and Imaging, Reproducibility of Result, colorectal cancer, Colorectal Neoplasm, Sensitivity and Specificity, Pattern Recognition, Automated, CT colonography, Multicenter trial, Humans, Medicine, In patient, Prospective Studies, Prospective cohort study, MED/01 - STATISTICA MEDICA, computer-aided detection, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Observer Variation, business.industry, LESS THAN 2 MINUTES, Reproducibility of Results, Middle Aged, Computer aided detection, Radiographic Image Enhancement, Algorithm, Prospective Studie, Italy, Prospective trial, Radiographic Image Interpretation, Computer-Assisted, Female, Colorectal Neoplasms, Nuclear medicine, business, Observer variation, Colonography, Computed Tomographic, Algorithms, Human
Abstract

To assess the effect of computer-aided detection (CAD) as a second reader on the sensitivity and specificity of computed tomographic (CT) colonography in detecting 6-9-mm colorectal cancer (CRC) lesions.Individuals with clinical indications for colonoscopy--either for symptoms or as part of participating in a surveillance program or CRC screening--were prospectively enrolled at one of 10 academic centers between July 2007 and May 2009. Institutional review board approval was obtained at each clinical site, and all participants provided written informed consent. All participants underwent CT colonography and colonoscopy on the same day. Experienced readers interpreted the CT colonography images unassisted and then reviewed all colorectal lesion-like structures pinpointed by the CAD algorithm. Segmental unblinding of CT colonoscopy findings at colonoscopy was utilized. The sensitivity and specificity of unassisted and CAD-assisted reading in identifying individuals with 6-9-mm lesions were calculated and compared by means of pairwise analysis.A total of 618 participants (mean age, 57.9 years; 54.5% male) were included in the final analysis. Of these participants, 464 (75.1%) had no lesions 6 mm or larger, and 52 (8.4%) had 6-9-mm lesions. The sensitivity of CT colonography with unassisted reading and that with CAD-assisted reading in identifying individuals with 6-9-mm lesions was 65.4% (95% confidence interval [CI]: 50.9%, 78.0%) and 76.9% (95% CI: 63.2%, 87.5%; P = .016), respectively. No significant change in specificity was observed: The specificity of CT colonography with unassisted and that with CAD-assisted reading was 91.8% (95% CI: 88.9%, 94.1%) and 90.9% (95% CI: 88.0%, 93.4%; P = .063), respectively. Evaluation of CAD candidates required an additional 1.6 minutes (25th-75th percentile: 1.0 minute to 3.4 minutes).The addition of CAD to reading performed by experienced readers resulted in a significant benefit in the detection of 6-9-mm polyps at CT colonography in this cohort.http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120376/-/DC1.

Published
2013

20. H. pylori Eradication in Primary Care: Modality of Treatment and Outcome

Author

Monica, P. Della, Lavagna, A., Masoero, G., Lombardo, L., Laudi, C., Crocella, L., Daperno, M., and Pera, A.

Subjects
Gastrointestinal diseases -- Research, Health, Research
Abstract

[15/23] H. pylori Eradication in Primary Care: Modality of Treatment and Outcome Helicobacter pylori treatment is a rapidly evolving field but if trial data may be translated into routine territory [...]

Published
2001

21. Multicenter, Prospective Surveillance Study of Staphylococcus aureus Nasal Colonization in 28 Italian Intensive Care Units: The ISABEL Study

Author

Viale, P, Gesu, G, Privitera, G, Allaria, B, Petrosillo, N, Zamparini, E, Scudeller, L, Albertario, F, Ferrari, L, Alvisi, R, Rita Rossi, M, Betto, C, Ripamonti, M, Castiglione, G, Di Vincenzo, F, Cerchiari, E, Gaspari, G, Pizzardi, Ca, Corsi, A, Piscina, A, De Zen, G, Tesser, A, Dei Poli, M, Costa, E, Ortisi, G, De Vivo, P, Libergoli, M, Della Rocca, G, Lanzafame, P, Favaro, M, Viola, G, Guarino, A, Capuzzo, R, Villa, Ao, Laudi, C, Sturla, C, Antonio Abate, S, Martinelli, G, Nannetti, A, Orsola, Os, Massei, R, Vaiani, R, Alessandra Manzoni, O, Mastroni, P, Sanna, S, Minoja, G, Tognolo, A, Onali, S, Sardi, B, Pelaia, P, Manso, E, Peris, A, Nicoletti, P, Perugini, M, Baldasarri, G, Piccinni, P, Rassu, M, Sinardi, A, Costa, G, Tetamo, R, Monastero, R, Tufano, R, Rossano, F, Tulli, G, Zamponi, E, Milano, F., Viale P, Gesu G, Privitera G, Allaria B, Petrosillo N, Zamparini E, and Scudeller L

Subjects
Microbiology (medical), Male, Methicillin-Resistant Staphylococcus aureus, medicine.medical_specialty, Staphylococcus aureus, Epidemiology, intensive care units, Staphylococcal infections, medicine.disease_cause, law.invention, law, Intensive care, medicine, Humans, Colonization, Prospective Studies, Intensive care medicine, Prospective cohort study, Proportional Hazards Models, Cross Infection, business.industry, biochemical phenomena, metabolism, and nutrition, Staphylococcal Infections, prospective multicenter study, bacterial infections and mycoses, medicine.disease, Methicillin-resistant Staphylococcus aureus, Intensive care unit, nasal colonization, Nasal Mucosa, Staphylococcus aureus, nasal colonization, intensive care units, Italy, prospective multicenter study, Infectious Diseases, Carriage, Italy, Emergency medicine, Female, business, Sentinel Surveillance
Abstract

The role of methicillin-resistant Staphylococcus aureus (MRSA) colonization as a predictor of invasive disease in intensive care unit (ICU) patients was established many years ago. The role of mefhicillin-susceptible Staphylococcus aureus (MSSA) colonization is more debated, although in a recent report patients who were carriers of MRSA or MSSA at ICU admission were found to be at increased risk. Whether carriage at ICU admission involves a higher risk of invasive infection than carriage acquired during an ICU stay has not been established. We report the results of a study aimed at estimating the frequency of S. aureus (MRSA and MSSA) colonization at admission and at discharge in patients admitted to several ICUs in Italy and at estimating the relationship between colonization status and infection by S. aureus.

Published
2011

24. Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer

Author

Regge, D, Laudi, C, Galatola, G, Della Monica, P, Bonelli, L, Angelelli, G, Asnaghi, R, Barbaro, Brunella, Bartolozzi, C, Bielen, D, Boni, L, Borghi, Claudio, Bruzzi, P, Cassinis, Mc, Galia, M, Gallo, Tm, Grasso, Alessandra, Hassan, Cesare, Laghi, A, Martina, Mc, Neri, Elisabetta, Senore, C, Simonetti, G, Venturini, S, Gandini, Gustavo, Barbaro, Brunella (ORCID:0000-0002-9638-543X), Regge, D, Laudi, C, Galatola, G, Della Monica, P, Bonelli, L, Angelelli, G, Asnaghi, R, Barbaro, Brunella, Bartolozzi, C, Bielen, D, Boni, L, Borghi, Claudio, Bruzzi, P, Cassinis, Mc, Galia, M, Gallo, Tm, Grasso, Alessandra, Hassan, Cesare, Laghi, A, Martina, Mc, Neri, Elisabetta, Senore, C, Simonetti, G, Venturini, S, Gandini, Gustavo, and Barbaro, Brunella (ORCID:0000-0002-9638-543X)

Abstract

Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC.

Published
2009

25. Clinical and molecular features of attenuated adenomatous polyposis in northern Italy

Author

de Leon, M. Ponz, primary, Urso, E. D. L., additional, Pucciarelli, S., additional, Agostini, M., additional, Nitti, D., additional, Roncucci, L., additional, Benatti, P., additional, Pedroni, M., additional, Kaleci, S., additional, Balsamo, A., additional, Laudi, C., additional, Di Gregorio, C., additional, Viel, A., additional, Rossi, G., additional, and Venesio, T., additional

Published
2012
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33. Gastric motility in chronic pancreatitis

Author

Masoem, G., primary, Laudi, C., additional, Crocellit, L., additional, Ruggia, O., additional, Della Monica, P., additional, Lombardo, L., additional, Rocca, R., additional, Lavagna, A., additional, and Pera, A., additional

Published
2001
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40. Clinical and molecular features of attenuated adenomatous polyposis in northern Italy.

Author

Leon, M., Urso, E., Pucciarelli, S., Agostini, M., Nitti, D., Roncucci, L., Benatti, P., Pedroni, M., Kaleci, S., Balsamo, A., Laudi, C., Di Gregorio, C., Viel, A., Rossi, G., and Venesio, T.

Subjects
ADENOMATOUS polyposis coli, COLON cancer diagnosis, GERM cells, RECTUM, GENETIC mutation, DIAGNOSIS
Abstract

Background: Attenuated familial adenomatous polyposis (AFAP) is characterized by the presence of 10-99 colorectal adenomas. The disease may be associated with mutations in either APC or MUTYH genes. We purposed to evaluate the contribution of adenomatous polyposis coli ( APC) and MutY homologue ( MUTYH) germline alterations to the AFAP phenotype and to identify genotype/phenotype correlations. Methods: During counselling for familial adenomatous polyposis (FAP), 91 probands (and 107 affected individuals) who met the criteria of AFAP were identified. Eighty-two families were screened for constitutional mutations of the APC and MUTYH genes. Results: MUTYH mutations were detected in 21 families (25.6 % of the 82 tested), and APC mutations in 7 (8.5 %). Overall, constitutional alterations were found in 34.1 % of the probands. Patients with APC mutations were younger at cancer onset and had a higher mean number of polyps (48.5 ± 33.0 in APC+ individuals vs. 35.7 ± 24.9 in MUTYH+ individuals, and 33.2 ± 18.4 in the 'no mutation' group). Clinical features rendered the 'no mutation' group closer to MUTYH+ than to the APC+ group. Colorectal cancer at diagnosis was detected in 40 % of AFAP individuals. Conclusions: AFAP is a new clinical entity with its frequency in the general population still undefined. The number of adenomas varies greatly, with an average of 30-40 lesions. The molecular basis of AFAP can be established in approximately 1/3 of the patients. Both MUTYH and APC genes are implicated in AFAP, though the role of MUTYH is of considerably greater relevance. [ABSTRACT FROM AUTHOR]

Published
2013
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47. Effects of pearl millet silage ammoniation with urea on carcass and meat quality of lambs

Author

CARVALHO, G. G. P. de, FREITAS, P. M. D. de, SANTOS, E. M., ARAUJO, G. G. L. de, OLIVEIRA, J. S. de, RODRIGUES, T. C. de C., ARAÚJO, M. L. G. M. L. de, ASSIS, D. Y. C. de, ROÇA, R. de O., DELBEM, N. L. C. de, LOMELE, R. L., LEITE, L. C., RODRIGUES, C. S., GLEIDSON G. P. DE CARVALHO, Federal University of Bahia, Salvador, BA, POLIANE MEIRE D. DE FREITAS, Federal University of Bahia, Salvador, BA, EDSON M. SANTOS, Federal University of Paraíba, Areia, PB, GHERMAN GARCIA LEAL DE ARAUJO, CPATSA, JULIANA S. DE OLIVEIRA, Federal University of Paraíba, Areia, PB, THOMAZ CYRO G. DE C. RODRIGUES, Federal University of Bahia, Salvador, BA, MARIA LEONOR G. M. L. DE ARAUJO, Federal University of Bahia, Salvador, BA, DALLYSON YEHUDI C. DE ASSIS, Federal University of Bahia, Salvador, BA, ROBERTO DE O. ROÇA, UNESP, Botucatu, SP, NARA LAIANE C. DE DELBEM, UNESP, Botucatu, SP, RENATA L. LOMELE, UNESP, Botucatu, SP, LAUDI C. LEITE, Federal University of Recôncavo da Bahia, Cruz das Almas, ba, and CARLINDO S. RODRIGUES, Instituto Federal de Educação, Ciência e Tecnologia Baiano - IFBaiano, Uruçuca, BA.

Subjects
Cortes comerciais, Proximate composition, Sheep, Composição centesimal, Cordeiro, Ovino, Qualidade da carne, Silagem, Uréia, Fatty acids, Silagem de milheto, Carcaça, Ácido Graxo
Abstract

This study aimed to evaluate the effect of pearl millet silage ammoniated with urea on lamb carcass characteristics and meat quality. Thirty-two noncastrated crossbred lambs at 4?5 months of age, with an average initial body weight of 17.39 ± 2.16 kg, were distributed into four treatments in a randomized block experimental design with eight animals per treatment. Experimental diets were composed of pearl millet silage ammoniated with four levels of urea (0%, 2%, 4% and 6%, on dry matter basis (DM). Carcass conformation and fatness decreased linearly (p < 0.05). Except for the fat content, the proximate composition was not influenced (p < 0.05) by the diets. Meat lightness and yellowness increased linearly (p < 0.05). There was no effect of diets (p > 0.05) on cooking losses or shear force. The levels of oleic and erucic fatty acid levels in the meat decreased linearly (p < 0.05), whereas linoleic and eicosadien-oic acids, polyunsaturated fatty acids, PUFA:SFA ratio and ω6 contents increased (p < 0.05). Pearl millet silage ammoniated with urea allows for the production of good-quality lamb meat, with greater concentrations of polyunsaturated fatty acids. However, lambs fed diets with pearl millet ammoniated with up to 6% lead to a reduction of carcass characteristics without significantly affecting loin-eye area possibly associated with low palatability of the additive used. The lower acceptance of the silages with higher levels of urea is due to the ammonia retention in the material is attributed to the ammonization process. Thus, in spite of the benefits on lamb meat quality, it is suggested that the use of this additive in the ammonization of tropical forages be carried out with care, in limits of up to 6%. Made available in DSpace on 2022-09-28T17:05:58Z (GMT). No. of bitstreams: 1 Effects-of-pearl-millet-silage-ammoniation-with-urea-on-carcass-2018.pdf: 705529 bytes, checksum: f4b821bea3e7740c20c1fab4f06cd012 (MD5) Previous issue date: 2018

Published
2018

48. Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer

Author

Giovanni Simonetti, Didier Bielen, Giovanni Gandini, Silvia Venturini, G. Galatola, Patrizia Della Monica, Andrea Grasso, Giuseppe Angelelli, Claudia Borghi, Carlo Bartolozzi, Cesare Hassan, Maria Carla Cassinis, Luca Boni, Carlo Senore, Daniele Regge, Teresa Gallo, Maria Cristina Martina, Brunella Barbaro, Paolo Bruzzi, Luigina Bonelli, C. Laudi, Massimo Galia, Andrea Laghi, Emanuele Neri, R. Asnaghi, Regge, D, Laudi, C, Galatola, G, Della Monica, P, Bonelli, L, Angelelli, G, Asnaghi, R, Barbaro, B, Bartolozzi, C, Bielen, D, Boni, L, Borghi, C, Bruzzi, P, Cassinis, MC, Galia, M, Gallo, TM, Grasso, A, Hassan, C, Laghi, A, Martina, MC, Neri, E, Senore, C, Simonetti, G, Venturini, S, and Gandini, G

Subjects
Male, occult blood test, Colorectal cancer, Colonoscopy, cancer risk, prediction and forecasting, Gastroenterology, Risk Factors, cancer diagnosis, Positive predicative value, advanced cancer, Medicine, Family history, comparative study, colorectal adenoma, family history, education.field_of_study, medicine.diagnostic_test, article, clinical trial, General Medicine, Middle Aged, priority journal, risk factor, Predictive value of tests, diagnostic accuracy, Female, diagnostic value, Colorectal Neoplasms, Colonography, Computed Tomographic, radiography, Computed Tomographic, Adult, medicine.medical_specialty, Settore MED/12 - GASTROENTEROLOGIA, Population, colorectal cancer, Sensitivity and Specificity, Predictive Value of Tests, Internal medicine, adult, aged, cancer classification, colonoscopy, computed tomographic colonography, controlled clinical trial, controlled study, cross-sectional study, female, human, major clinical study, male, multicenter study, predictive validity, colorectal tumor, middle aged, sensitivity and specificity, Aged, Cross-Sectional Studies, Humans, education, business.industry, Fecal occult blood, Sigmoidoscopy, Colonography, medicine.disease, CT colonography, colorectal cancer, screening, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, business
Abstract

CONTEXT: Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC. OBJECTIVE: To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard. DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positive results from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Belgian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same day. MAIN OUTCOME MEASURES: Sensitivity and specificity of CT colonography in detecting individuals with advanced neoplasia (ie, advanced adenoma or CRC) 6 mm or larger. RESULTS: Of 1103 participants, 937 were included in the final analysis: 373 cases in the family-history group, 343 in the group with personal history of adenomas, and 221 in the FOBT-positive group. Overall, CT colonography identified 151 of 177 participants with advanced neoplasia 6 mm or larger (sensitivity, 85.3%; 95% confidence interval [CI], 79.0%-90.0%) and correctly classified results as negative for 667 of 760 participants without such lesions (specificity, 87.8%; 95% CI, 85.2%-90.0%). The positive and negative predictive values were 61.9% (95% CI, 55.4%-68.0%) and 96.3% (95% CI, 94.6%-97.5%), respectively; after group stratification, a significantly lower negative predictive value was found for the FOBT-positive group (84.9%; 95% CI, 76.2%-91.3%; P < .001). CONCLUSIONS: In a group of persons at increased risk for CRC, CT colonography compared with colonoscopy resulted in a negative predictive value of 96.3% overall. When limited to FOBT-positive persons, the negative predictive value was 84.9%.

Published
2009

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