Search

Your search keyword '"Laura, Gigante"' showing total 26 results
Start Over Author "Laura, Gigante"
26 results on '"Laura, Gigante"'

2. Sarilumab use in severe SARS-CoV-2 pneumonia

Author

Elisa Gremese, Antonella Cingolani, Silvia Laura Bosello, Stefano Alivernini, Barbara Tolusso, Simone Perniola, Francesco Landi, Maurizio Pompili, Rita Murri, Angelo Santoliquido, Matteo Garcovich, Michela Sali, Gennaro De Pascale, Maurizio Gabrielli, Federico Biscetti, Massimo Montalto, Alberto Tosoni, Giovanni Gambassi, Gian Ludovico Rapaccini, Amerigo Iaconelli, Lorenzo Zileri Del Verme, Luca Petricca, Anna Laura Fedele, Marco Maria Lizzio, Enrica Tamburrini, Gerlando Natalello, Laura Gigante, Dario Bruno, Lucrezia Verardi, Eleonora Taddei, Angelo Calabrese, Francesco Lombardi, Roberto Bernabei, Roberto Cauda, Francesco Franceschi, Raffaele Landolfi, Luca Richeldi, Maurizio Sanguinetti, Massimo Fantoni, Massimo Antonelli, and Antonio Gasbarrini

Subjects
Severe sars-cov-2 pneumonia, Sarilumab, Inflammation, Medicine (General), R5-920
Abstract

Background: Interleukin-6 signal blockade showed preliminary beneficial effects in treating inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Herein we describe the outcomes of off-label intravenous use of Sarilumab in severe SARS-CoV-2-related pneumonia. Methods: 53 patients with SARS-CoV-2 severe pneumonia received intravenous Sarilumab; pulmonary function improvement or Intensive Care Unit (ICU) admission rate in medical wards, live discharge rate in ICU treated patients and safety profile were recorded. Sarilumab 400 mg was administered intravenously on day 1, with eventual additional infusion based on clinical judgement, and patients were followed for at least 14 days, unless previously discharged or dead. Findings: Of the 53 SARS-CoV-2pos patients receiving Sarilumab, 39(73·6%) were treated in medical wards [66·7% with a single infusion; median PaO2/FiO2:146(IQR:120–212)] while 14(26·4%) in ICU [92·6% with a second infusion; median PaO2/FiO2: 112(IQR:100–141.5)].Within the medical wards, 7(17·9%) required ICU admission, 4 of whom were re-admitted to the ward within 5–8 days. At 19 days median follow-up, 89·7% of medical inpatients significantly improved (46·1% after 24 h, 61·5% after 3 days), 70·6% were discharged from the hospital and 85·7% no longer needed oxygen therapy. Within patients receiving Sarilumab in ICU, 64·2% were discharged from ICU to the ward and 35·8% were still alive at the last follow-up. Overall mortality rate was 5·7%. Interpretation: IL-6R inhibition appears to be a potential treatment strategy for severe SARS-CoV-2 pneumonia and intravenous Sarilumab seems a promising treatment approach showing, in the short term, an important clinical outcome and good safety.

Published
2020
Full Text
View/download PDF

4. A audiência de custódia na lei anticrime (Lei nº 13.964/2019)

Author

Laura Gigante Albuquerque and Júlia Tormen Fusinato

Subjects
Audiência de Custódia, Lei Anticrime (Lei nº 13.964/2019), Processo Penal, Jurisprudence. Philosophy and theory of law, K201-487, Political institutions and public administration (General), JF20-2112
Abstract

A audiência de custódia foi implantada no Brasil em 2015, por iniciativa do Conselhob Nacional de Justiça. No entanto, apenas recentemente, a partir da Lei nº 13.964/2019, ela foi incorporada ao Código de Processo Penal. O presente artigo tem como objetivo retratar o contexto em que esse instrumento foi inserido no ordenamento jurídico brasileiro, bem como seus objetivos e procedimento. Apresentam-se as alterações trazidas pela denominada Lei Anticrime questionando, especialmente, a nova redação prevista no artigo 287 do Código de Processo Penal e a possibilidade de facultar a realização da audiência para alguns tipos de prisão, bem como a (in)constitucionalidade do § 2º do artigo 310 do mesmo diploma, e à impossibilidade de liberdade provisória para alguns casos.

Published
2020

5. Legalidade processual e a aplicação do acordo de não persecução penal em processos em curso procedural

Author

Daniela Dora Eilberg and Laura Gigante Albuquerque

Subjects
Acordo de não persecução penal (ANPP), Retroatividade, Lei processual penal, Legalidade, Pacote anticrime, Jurisprudence. Philosophy and theory of law, K201-487, Political institutions and public administration (General), JF20-2112
Abstract

A legalidade, compreendida como princípio norteador do direito penal material e processual penal, vem sofrendo tensionamentos em que corriqueiramente é coagida. A observância de tal princípio assume papel imprescindível no processo de mitigação de arbitrariedades cometidas pelos juízes dentro do espectro de um processo penal democrático e de matriz acusatória. A questão enfrentada assume papel protagonista quanto aos limites da legalidade face à lógica massiva de negociação penal. O Pacote Anticrime, dentro dessa dinâmica negocial, previu o acordo de não persecução penal (ANPP) como uma nova prática procedimental dentro do processo penal. Portanto, este artigo visa a questionar dogmaticamente, por meio de pesquisa bibliográfica, a aplicabilidade do ANPP em processos penais em curso

Published
2020

6. Treatment strategy introducing immunosuppressive drugs with glucocorticoids ab initio or very early in giant cell arteritis: A multicenter retrospective controlled study

Author

Luca Quartuccio, Miriam Isola, Dario Bruno, Elena Treppo, Laura Gigante, Francesca Angelotti, Riccardo Capecchi, Gianfranco Vitiello, Elena Cavallaro, Antonio Tavoni, Silvia Laura Bosello, Daniele Cammelli, Salvatore De Vita, and Elisa Gremese

Subjects
Giant cell arteritis, Temporal arteritis, Treatment, Glucocorticoids, Methotrexate, Tocilizumab, Immunologic diseases. Allergy, RC581-607
Abstract

Objective: Glucocorticoids (GC) are associated with side effects in giant cell arteritis (GCA). Immunosuppressive therapies (ITs) have given conflicting results in GCA, regarding GC sparing effect. Primary endpoint is to evaluate whether very early introduction of ITs in GCA minimize the rate of GC-induced adverse events, in terms of infections, new onset systemic arterial hypertension, GC-induced diabetes and osteoporotic fractures. Methods: A multicenter retrospective case-control study included 165 patients. One group included 114 patients who were treated with at least one IT given at diagnosis or within 3 months from the start of GC. A second group included 51 GCA who received only GC or an IT more than 3 months later. Results: The most frequently used ITs were: methotrexate (138 patients), cyclophosphamide (48 patients) and tocilizumab (27 patients). No difference was observed as concerns the follow-up time between groups [48.5 (IQR 26–72) vs 40 (IQR 24–69), p ​= ​0.3)]. The first group showed a significantly lower incidence of steroid-induced diabetes (8/114, 7% vs 12/51, 23.5%; p ​= ​0.003) and no differences for the rate of infections (p ​= ​0.64). The group was also exposed to lower doses of GC at first (p ​

Published
2020
Full Text
View/download PDF

7. Multidisciplinary Evaluation of Interstitial Lung Diseases: New Opportunities Linked to Rheumatologist Involvement

Author

Enrico De Lorenzis, Silvia Laura Bosello, Francesco Varone, Giacomo Sgalla, Lucio Calandriello, Gerlando Natalello, Bruno Iovene, Giuseppe Cicchetti, Laura Gigante, Lucrezia Verardi, Elisa Gremese, Luca Richeldi, and Anna Rita Larici

Subjects
interstitial lung disease, systemic rheumatic autoimmune disease, connective tissue disease, rheumatoid arthritis, interstitial pneumonia with autoimmune features, multidisciplinary team, Medicine (General), R5-920
Abstract

Multidisciplinary team (MDT) discussion is the gold standard in the management of interstitial lung disease (ILD). The rheumatologist is not routinely involved in MDT, even if up to 20% of ILD are related to systemic autoimmune rheumatic diseases (SARD). The study aims to assess the agreement and its variation over time between rheumatologists and pulmonologists in the screening of SARD and between rheumatologists and an MDT extended to rheumatologists (eMDT) in evaluating the progression of SARD. We computed the agreement between the pulmonologist and rheumatologist in the identification of red flags for SARDs of 81 ILD cases and between the rheumatologist alone and eMDT in the confirmation of 70 suspected SARD-ILD progressions. The agreement between rheumatologists and pulmonologists was moderate for the detection of autoimmunity test positivity (κ = 0.475, p < 0.001) and family history of SARD (κ = 0.491, p < 0.001) and fair for the identification of extrapulmonary symptoms (κ = 0.225, p = 0.064) or routine laboratory abnormalities consistent with SARD. The average agreement between the rheumatologist and eMDT in the identification of ILD progression was moderate (κ = 0.436, p < 0.001). The class of agreement improved from the first to the third semester. The average agreement with the rheumatologist ranged from fair to moderate, suggesting that a shared evaluation of SARD-ILD in eMDT could improve the diagnostic work-up and the evaluation of ILD progression.

Published
2020
Full Text
View/download PDF

8. Predicting <scp>In‐Hospital</scp> Mortality in <scp>COVID</scp> ‐19 Older Patients with Specifically Developed Scores

Author

Lorenzo Maria Vetrone, Mariangela Antonelli, Giuseppe De Matteis, Alessandro BUONOMO, Antonio Gasbarrini, Rosario Landi, Maurizio Sanguinetti, Francesco Antonio Mancarella, Riccardo Inchingolo, Francesco Santopaolo, Silvia Bosello, Claudio Sandroni, Caterina Guidone, Vincenzo Bove, Carlo Romano Settanni, Raffaele Iorio, Annamaria Carnicelli, Andrea FLEX, Cristiano Caruso, Benedetta Simeoni, Elisabetta Nardella, Lucia Cerrito, Nicola Acampora, Maurizio Gabrielli, Maria Valeria Matteo, Angelo Carfì, Laura Gigante, Domenico Fusco, Valerio Pontecorvi, Matteo Tosato, Paolo Santini, Antonella Giampietro, Davide Moschese, Martina Petrucci, Francesco De Vito, Dario Bruno, LUCREZIA VERARDI, Tommaso Schepis, Elisa Gremese, Francesco Lombardi, Luca Sabia, Marcello Covino, Anna Maria Martone, Leonardo Stella, Gerlando Natalello, Marcello Candelli, Fabio Del Zompo, Giuseppe Parrinello, Giulia Pignataro, Gabriele Rumi, Federico Rosa, and Emanuele Marzetti

Subjects
Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Critical Illness, ISARIC‐, 030204 cardiovascular system & hematology, Severity of Illness Index, COVID‐GRAM, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, GRAM, Older patients, COVID‐19, Internal medicine, Settore MED/41 - ANESTESIOLOGIA, ISARIC‐4C, qCSI, Humans, Medicine, Hospital Mortality, 030212 general & internal medicine, Letters to the Editor, 4C, Letter to the Editor, Aged, Retrospective Studies, Framingham Risk Score, In hospital mortality, business.industry, Brief Report, Settore MED/09 - MEDICINA INTERNA, COVID-19, Retrospective cohort study, NEWS, Emergency department, Middle Aged, Early warning score, Italy, Early Warning Score, Emergency medicine, Cohort, Brief Reports, Female, Geriatrics and Gerontology, Emergency Service, Hospital, business
Abstract

BACKGROUND/OBJECTIVES: Several scoring systems have been specifically developed for risk stratification in COVID-19 patients. DESIGN: We compared, in a cohort of confirmed COVID-19 older patients, three specifically developed scores with a previously established early warning score. Main endpoint was all causes in-hospital death. SETTING: This is a single-center, retrospective observational study, conducted in the Emergency Department (ED) of an urban teaching hospital, referral center for COVID-19. PARTICIPANTS: We reviewed the clinical records of the confirmed COVID-19 patients aged 60 years or more consecutively admitted to our ED over a 6-week period (March 1st to April 15th, 2020). A total of 210 patients, aged between 60 and 98 years were included in the study cohort. MEASUREMENTS: International Severe Acute Respiratory Infection Consortium Clinical Characterization Protocol-Coronavirus Clinical Characterization Consortium (ISARIC-4C) score, COVID-GRAM Critical Illness Risk Score (COVID-GRAM), quick COVID-19 Severity Index (qCSI), National Early Warning Score (NEWS). RESULTS: Median age was 74 (67-82) and 133 (63.3%) were males. Globally, 42 patients (20.0%) deceased. All the score evaluated showed a fairly good predictive value with respect to in-hospital death. The ISARIC-4C score had the highest area under ROC curve (AUROC) 0.799 (0.738-0.851), followed by the COVID-GRAM 0.785 (0.723-0.838), NEWS 0.764 (0.700-0.819), and qCSI 0.749 (0.685-0.806). However, these differences were not statistical significant. CONCLUSION: Among the evaluated scores, the ISARIC-4C and the COVID-GRAM, calculated at ED admission, had the best performance, although the qCSI had similar efficacy by evaluating only three items. However, the NEWS, already widely validated in clinical practice, had a similar performance and could be appropriate for older patients with COVID-19.

Published
2020
Full Text
View/download PDF

9. Non-Ceruloplasmin Copper Identifies a Subtype of Alzheimer’s Disease (CuAD): Characterization of the Cognitive Profile and Case of a CuAD Patient Carrying an RGS7 Stop-Loss Variant

Author

Rosanna Squitti, Claudio Catalli, Laura Gigante, Massimo Marianetti, Mattia Rosari, Stefania Mariani, Serena Bucossi, Gioia Mastromoro, Mariacarla Ventriglia, Ilaria Simonelli, Vincenzo Tondolo, Parminder Singh, Ashok Kumar, Amit Pal, and Mauro Rongioletti

Subjects
Inorganic Chemistry, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, Molecular Biology, Alzheimer’s disease, ceruloplasmin, copper, non-bound ceruloplasmin copper, metals, dementia, executive functions, dopamine, Iron, G-protein, RGS7, stop-loss mutation, Spectroscopy, Catalysis, Computer Science Applications
Abstract

Alzheimer’s disease (AD) is a type of dementia whose cause is incompletely defined. Copper (Cu) involvement in AD etiology was confirmed by a meta-analysis on about 6000 participants, showing that Cu levels were decreased in AD brain specimens, while Cu and non-bound ceruloplasmin Cu (non-Cp Cu) levels were increased in serum/plasma samples. Non-Cp Cu was advocated as a stratification add-on biomarker of a Cu subtype of AD (CuAD subtype). To further circumstantiate this concept, we evaluated non-Cp Cu reliability in classifying subtypes of AD based on the characterization of the cognitive profile. The stratification of the AD patients into normal AD (non-Cp Cu ≤ 1.6 µmol/L) and CuAD (non-Cp Cu > 1.6 µmol/L) showed a significant difference in executive function outcomes, even though patients did not differ in disease duration and severity. Among the Cu-AD patients, a 76-year-old woman showed significantly abnormal levels in the Cu panel and underwent whole exome sequencing. The CuAD patient was detected with possessing the homozygous (c.1486T > C; p.(Ter496Argext*19) stop-loss variant in the RGS7 gene (MIM*602517), which encodes for Regulator of G Protein Signaling 7. Non-Cp Cu as an add-on test in the AD diagnostic pathway can provide relevant information about the underlying pathological processes in subtypes of AD and suggest specific therapeutic options.

Published
2023
Full Text
View/download PDF

10. Sudden winter iloprost withdrawal in scleroderma patients during COVID-19 pandemic

Author

Enrico, De Lorenzis, Gerlando, Natalello, Lucrezia, Verardi, Pier Giacomo, Cerasuolo, Laura, Gigante, Maria Antonietta, D'Agostino, and Silvia Laura, Bosello

Subjects
Scleroderma, Systemic, Settore MED/16 - REUMATOLOGIA, COVID-19, Raynaud Disease, Cell Biology, Biochemistry, Skin Ulcer, Nailfold capillaroscopy, Humans, Systemic sclerosis, Iloprost, Cardiology and Cardiovascular Medicine, Pandemics, Ulcer
Abstract

Intravenous iloprost is currently recommended in the treatment of Raynaud's phenomenon (RP) refractory to oral therapy and of digital ulcers (DUs) related to systemic sclerosis (SSc). In real-life practice there is a huge heterogeneity about the Iloprost regimens used.A survey was carried out on SSc patients that interrupted Iloprost infusion to compare acral vascular symptoms just before Iloprost withdrawal and just after the missed infusion. Severity, and frequency of RP, new DUs onset or aggravation of those pre-existing were reported. Last available capillaroscopic images were also evaluated.The analysis includes 50 patients. After iloprost withdrawal, 11 patients reported a RP worsening because of enhanced intensity (p = 0.007). Only 8 patients of them also complained of an increased frequency (p = 0.07). None of the patients experienced digital ulcers for the first-time during quarantine. Among the 27 patients with a history of digital ulcers, 9 reported worsening and 7 recurrence of DUs. Overall, 17 patients (34.0 %) complained of a worsening of SSc vascular acral manifestations, namely RP or DUs. Reduced capillary density was associated with RP worsening, in particular, each unit increase of capillary density corresponds to an average 44 % decrease in the odds of RP worsening (OR 0.56, CI 95 % 0.36-0.97, p = 0.037). As for RP worsening, the aggravation of DU was associated with a lower capillary density.Low capillary density can predict a worsening of both RP and DUs in controlled quarantine conditions within a month after iloprost discontinuation in SSc patients.

Published
2022

11. NIPAT as Non-Invasive Prenatal Paternity Testing Using a Panel of 861 SNVs

Author

Riccardo Giannico, Luca Forlani, Valentina Andrioletti, Ettore Cotroneo, Andrea Termine, Carlo Fabrizio, Raffaella Cascella, Luca Salvaderi, Pasquale Linarello, Debora Varrone, Laura Gigante, and Emiliano Giardina

Subjects
NIPAT, NGS, Genetics, paternity test, cffDNA, Genetics (clinical)
Abstract

In 1997, it was discovered that maternal plasma contains Cell-Free Fetal DNA (cffDNA). cffDNA has been investigated as a source of DNA for non-invasive prenatal testing for fetal pathologies, as well as for non-invasive paternity testing. While the advent of Next Generation Sequencing (NGS) led to the routine use of Non-Invasive Prenatal Screening (NIPT or NIPS), few data are available regarding the reliability and reproducibility of Non-Invasive Prenatal Paternity Testing (NIPPT or NIPAT). Here, we present a non-invasive prenatal paternity test (NIPAT) analyzing 861 Single Nucleotide Variants (SNV) from cffDNA through NGS technology. The test, validated on more than 900 meiosis samples, generated log(CPI)(Combined Paternity Index) values for designated fathers ranging from +34 to +85, whereas log(CPI) values calculated for unrelated individuals were below −150. This study suggests that NIPAT can be used with high accuracy in real cases.

Published
2023
Full Text
View/download PDF

13. Residual respiratory impairment after COVID-19 pneumonia

Author

Lombardi, Francesco, Calabrese, Angelo, Iovene, Bruno, Pierandrei, Chiara, Lerede, Marialessia, Varone, Francesco, Richeldi, Luca, Sgalla, Giacomo, Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Benvenuto, Francesca, Bramato, Giulia, Carfi', Angelo, Ciciarello, Francesca, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Carmen, Napolitano, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Anna, Picca, Giulia, Savera, Tamburrini, Enrica, Borghetti, Alberto, Simona Di Gianbenedetto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Davide, Moschese, Arturo, Ciccullo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Gertrude, Mingrone, Zocco, Maria Assunta, Mauirizio, Sanguinetti, Cattani Franchi, Paola, Marchetti, Simona, Alessandro, Bizzarro, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Maria Grazia Cozzupoli, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Giovanni Di Cintio, Ylenia, Longobardi, Laura, Tricarico, Santantonio, Mariaconsiglia, Buonsenso, Danilo, Valentini, Piero, Davide, Pata, Davide, Sinatti, De Rose, Cristina, Aangelo, Calabrese, Sani, Gabriele, Delfina, Janiri, Giulia, Giuseppin, Marzia, Molinaro, Modica, Marco, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Annamaria, Paglionico, Petricca, Luca, Laura, Gigante, Gerlando, Natalello, Fedele, Anna Laura, Lizzio, Marco Maria, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, and Valentina, Popolla

Subjects
Male, Pulmonary and Respiratory Medicine, Percent Predicted Total Lung Capacity, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, Partial Pressure, Pneumonia, Viral, Walk Test, 030204 cardiovascular system & hematology, dyspnoea, Severity of Illness Index, Pulmonary function testing, Diseases of the respiratory system, 03 medical and health sciences, PFT, 0302 clinical medicine, Percent Predicted Residual Volume, DLCO, cough, Diffusing capacity, 6MWT, Humans, Medicine, Respiratory function, Lung volumes, Aged, COVID, Carbon Monoxide, Exercise Tolerance, RC705-779, SARS-CoV-2, business.industry, Research, Settore MED/09 - MEDICINA INTERNA, COVID-19, Middle Aged, Oxygen, Residual Volume, Dyspnea, 030228 respiratory system, Respiratory failure, Anesthesia, Pulmonary Diffusing Capacity, Female, ABG, Blood Gas Analysis, business
Abstract

Introduction The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential for long-term respiratory sequelae in these patients. We assessed the respiratory function in a cohort of patients after recovering from SARS-Cov-2 infection, stratified according to PaO2/FiO2 (p/F) values. Method Approximately one month after hospital discharge, 86 COVID-19 patients underwent physical examination, arterial blood gas (ABG) analysis, pulmonary function tests (PFTs), and six-minute walk test (6MWT). Patients were also asked to quantify the severity of dyspnoea and cough before, during, and after hospitalization using a visual analogic scale (VAS). Seventy-six subjects with ABG during hospitalization were stratified in three groups according to their worst p/F values: above 300 (n = 38), between 200 and 300 (n = 30) and below 200 (n = 20). Results On PFTs, lung volumes were overall preserved yet, mean percent predicted residual volume was slightly reduced (74.8 ± 18.1%). Percent predicted diffusing capacity for carbon monoxide (DLCO) was also mildly reduced (77.2 ± 16.5%). Patients reported residual breathlessness at the time of the visit (VAS 19.8, p Conclusion Approximately one month after hospital discharge, patients with COVID-19 can have residual respiratory impairment, including lower exercise tolerance. The extent of this impairment seems to correlate with the severity of respiratory failure during hospitalization.

Published
2021

14. Asthma in patients admitted to emergency department for COVID-19: prevalence and risk of hospitalization

Author

Gabrielli, Maurizio, Pignataro, Giulia, Candelli, Marcello, Sacco Fernandez, Marta, Bizzarri, Martina, Esperide, Alessandra, Franceschi, Francesco, Abbate, Valeria, Nicola, Acampora, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Mariangela, Antonelli, Antonucci, Gabriele, Marco, Anzellotti Gian, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Fabiana, Barone, Bellantone, Rocco Domenico Alfonso, Andrea, Bellieni, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Stefano, Bibbò, Bini, Alessandra, Alessandra, Bisanti, Biscetti, Federico, Bocci, Maria Grazia, Nicola, Bonadia, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia Laura, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Teresa, Bruni, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Livia, Burzo, Angelo, Calabrese, Rosaria, Calvello Maria, Andrea, Cambieri, Cambise, Chiara, Camma, Giulia, Gennaro, Canistro, Antonello, Cantanale, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Silvia, Cardone, Carelli, Simone, Carfi', Angelo, Annamaria, Carnicelli, Caruso, Cristiano, Antonio, Casciaro Francesco, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Melania, Cesarano, Chiarito, Annalisa, Cianci, Rossella, Cicetti, Marta, Cicchinelli, Sara, Arturo, Ciccullo, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Ludovica Maria, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Matteo, Costanzi, Covino, Marcello, Davide, Crupi, Lucio, Cutuli Salvatore, D'Addio, Stefano, D'Alessandro, Alessia, D'Alfonso, Maria Elena, D'Angelo, Emanuela, Francesca, D’Aversa, Damiano, Fernando, De Maria, Berardinis Gian, De Cunzo, Tommaso, De Gaetano Donati, Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Paolo, Santis, De Martina, Siena, De Francesco, Vito, Del Valeria, Gatto, Del Paola, Giacomo, Del Fabio, Zompo, Maria, Dell’Anna Antonio, Della Davide, Polla, Di Luca, Gialleonardo, Di Simona, Giambenedetto, Di Roberta, Luca, Di Luca, Maurizio, Di Mariangela, Muro, Alex, Dusina, Davide, Eleuteri, Alessandra, Esperide, Daniele, Facheci, Domenico, Faliero, Cinzia, Falsiroli, Massimo, Fantoni, Annalaura, Fedele, Daniela, Feliciani, Cristina, Ferrante, Giuliano, Ferrone, Rossano, Festa, Chiara, Fiore Maria, Andrea, Flex, Evelina, Forte, Francesco, Franceschi, Alessandra, Francesconi, Laura, Franza, Barbara, Funaro, Mariella, Fuorlo, Domenico, Fusco, Maurizio, Gabrielli, Eleonora, Gaetani, Claudia, Galletta, Antonella, Gallo, Giovanni, Gambassi, Matteo, Garcovich, Antonio, Gasbarrini, Irene, Gasparrini, Silvia, Gelli, Antonella, Giampietro, Laura, Gigante, Gabriele, Giuliano, Giorgia, Giuliano, Bianca, Giupponi, Elisa, Gremese, Luca, Grieco Domenico, Manuel, Guerrera, Valeria, Guglielmi, Caterina, Guidone, Antonio, Gullì, Amerigo, Iaconelli, Aurora, Iafrati, Ianiro, Gianluca, Angela, Iaquinta, Michele, Impagnatiello, Riccardo, Inchingolo, Enrica, Intini, Raffaele, Iorio, Maria, Izzi Immacolata, Tamara, Jovanovic, Cristina, Kadhim, Rosa, La Macchia, Ignazio, La Milia Daniele, Francesco, Landi, Giovanni, Landi, Rosario, Landi, Raffaele, Landolfi, Massimo, Leo, Maria, Leone Paolo, Laura, Levantesi, Antonio, Liguori, Rosa, Liperoti, Maria, Lizzio Marco, Rita, Lo Monaco Maria, Pietro, Locantore, Francesco, Lombardi, Gianmarco, Lombardi, Loris, Lopetuso, Valentina, Loria, Raffaella, Losito Angela, Patricia, Lucia Mothanje Barbara, Francesco, Macagno, Noemi, Macerola, Giampaolo, Maggi, Giuseppe, Maiuro, Francesco, Mancarella, Francesca, Mangiola, Alberto, Manno, Debora, Marchesini, Marco, Maresca Gian, Giuseppe, Marrone, Ilaria, Martis, Maria, Martone Anna, Marzetti, Emanuele, Chiara, Mattana, Valeria, Matteo Maria, Riccardo, Maviglia, Ada, Mazzarella, Carmen, Memoli, Luca, Miele, Alessio, Migneco, Irene, Mignini, Alessandro, Milani, Domenico, Milardi, Massimo, Montalto, Giuliano, Montemurro, Flavia, Monti, Montini, Luca, Christian, Morena Tony, Vincenzina, Morra, Davide, Moschese, Ambra, Murace Celeste, Martina, Murdolo, Rita, Murri, Marco, Napoli, Elisabetta, Nardella, Gerlando, Natalello, Daniele, Natalini, Maria, Navarra Simone, Antonio, Nesci, Alberto, Nicoletti, Rocco, Nicoletti, Filippo, Nicoletti Tommaso, Rebecca, Nicolò, Nicola, Nicolotti, Celestino, Nista Enrico, Eugenia, Nuzzo, Marco, Oggiano, Veronica, Ojetti, Cosimo, Pagano Francesco, Gianfranco, Paiano, Cristina, Pais, Federico, Paolillo, Federico, Pallavicini, Andrea, Palombo, Alfredo, Papa, Domenico, Papanice, Giovanni, Papparella Luigi, Mattia, Paratore, Giuseppe, Parrinello, Giuliana, Pasciuto, Pierpaolo, Pasculli, Giovanni, Pecorini, Simone, Perniola, Erika, Pero, Luca, Petricca, Martina, Petrucci, Chiara, Picarelli, Andrea, Piccioni, Annalisa, Piccolo, Edoardo, Piervincenzi, Giulia, Pignataro, Raffaele, Pignataro, Gabriele, Pintaudi, Luca, Pisapia, Marco, Pizzoferrato, Fabrizio, Pizzolante, Roberto, Pola, Caterina, Policola, Maurizio, Pompili, Flavia, Pontecorvi, Valerio, Pontecorvi, Francesca, Ponziani, Valentina, Popolla, Enrica, Porceddu, Angelo, Porfidia, Maria, Porro Lucia, Annalisa, Potenza, Francesca, Pozzana, Giuseppe, Privitera, Daniela, Pugliese, Gabriele, Pulcini, Simona, Racco, Francesca, Raffaelli, Vittoria, Ramunno, Ludovico, Rapaccini Gian, Richeldi, Luca, Rinninella, Emanuele, Sara, Rocchi, Bruno, Romanò, Stefano, Romano, Federico, Rosa, Laura, Rossi, Raimondo, Rossi, Enrica, Rossini, Elisabetta, Rota, Fabiana, Rovedi, Carlotta, Rubino, Gabriele, Rumi, Andrea, Russo, Luca, Sabia, Andrea, Salerno, Sara, Salini, Lucia, Salvatore, Dehara, Samori, Sandroni, Claudio, Maurizio, Sanguinetti, Luca, Santarelli, Paolo, Santini, Danilo, Santolamazza, Angelo, Santoliquido, Francesco, Santopaolo, Cosimo, Santoro Michele, Francesco, Sardeo, Caterina, Sarnari, Angela, Saviano, Luisa, Saviano, Scaldaferri, Franco, Roberta, Scarascia, Tommaso, Schepis, Francesca, Schiavello, Giancarlo, Scoppettuolo, Davide, Sedda, Flaminio, Sessa, Luisa, Sestito, Carlo, Settanni, Matteo, Siciliano, Valentina, Siciliano, Rossella, Sicuranza, Benedetta, Simeoni, Jacopo, Simonetti, Andrea, Smargiassi, Maurizio, Soave Paolo, Chiara, Sonnino, Domenico, Staiti, Claudia, Stella, Leonardo, Stella, Eleonora, Stival, Eleonora, Taddei, Rossella, Talerico, Elio, Tamburello, Enrica, Tamburrini, Sofia, Tanzarella Eloisa, Elena, Tarascio, Claudia, Tarli, Alessandra, Tersali, Pietro, Tilli, Jacopo, Timpano, Enrico, Torelli, Flavia, Torrini, Matteo, Tosato, Alberto, Tosoni, Luca, Tricoli, Marcello, Tritto, Mario, Tumbarello, Maria, Tummolo Anita, Sole, Vallecoccia Maria, Federico, Valletta, Francesco, Varone, Francesco, Vassalli, Giulio, Ventura, Lucrezia, Verardi, Lorenzo, Vetrone, Giuseppe, Vetrugno, Elena, Visconti, Felicia, Visconti, Andrea, Viviani, Raffaella, Zaccaria, Carmelina, Zaccone, Lorenzo, Zelano, Lorenzo, Zileri Dal Verme, and Giuseppe, Zuccalà

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Emergency department, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, asthma, medicine.disease, Hospitalization, Emergency medicine, CE-Research Letter to the Editor, SARS-CoV2, Emergency Medicine, Internal Medicine, medicine, Prevalence, Humans, In patient, business, Emergency Service, Hospital, Asthma, Retrospective Studies
Published
2021

15. Incidental SOS1 variant identified by non-invasive prenatal screening: Prenatal diagnosis and family clinical reassessment

Author

M. Baldi, Antonio Pizzuti, Daniele Guadagnolo, Laura Gigante, Gioia Mastromoro, Paolo Versacci, Enrica Marchionni, Flavia Ventriglia, and Francesca Di Palma

Subjects
medicine.medical_specialty, Obstetrics, business.industry, Non invasive, MEDLINE, Obstetrics and Gynecology, Prenatal diagnosis, Aneuploidy, Prenatal screening, Reproductive Medicine, Pregnancy, Prenatal Diagnosis, medicine, Humans, Female, business
Published
2020

16. Letter: prevalence and patterns of gastrointestinal symptoms in a large Western cohort of patients with COVID-19

Author

Lorenzo Maria Vetrone, Luisa Sestito, Angelo Porfidia, Alessandro BUONOMO, Antonio Gasbarrini, Rosario Landi, Laura Franza, Maurizio Sanguinetti, Francesco Antonio Mancarella, Riccardo Inchingolo, Silvia Bosello, Andrea Corsello, Francesca Ciciarello, Caterina Guidone, Vincenzo Bove, Martina De Siena, Carlo Romano Settanni, Luca Miele, Mattia Paratore, Raffaele Iorio, Gianluca Ianiro, Cristiano Caruso, Elisabetta Nardella, Alfredo PAPA, Stefano Bibbò, Maurizio Gabrielli, Simone Perniola, Angelo Carfì, Laura Gigante, Domenico Fusco, Valerio Pontecorvi, Paolo Santini, Antonella Giampietro, Impagnatiello Michele, Gabriele Pulcini, Giovanni Cammarota, Serena PORCARI, Massimo FANTONI, Federico Biscetti, Francesco De Vito, Dario Bruno, Luca Petricca, LUCREZIA VERARDI, Jacopo Simonetti, Tommaso Schepis, Tommaso Nicoletti, Elisa Gremese, Francesco Lombardi, Leonardo Stella, Gerlando Natalello, Flavio De Maio, Giuseppe Parrinello, and Gabriele Rumi

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Hepatology, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Settore MED/09 - MEDICINA INTERNA, Gastroenterology, MEDLINE, Letter to the Editors, Letters to the Editors, 03 medical and health sciences, 0302 clinical medicine, covid-19, Internal medicine, Cohort, medicine, 030211 gastroenterology & hepatology, Pharmacology (medical), 030212 general & internal medicine, business
Abstract

LINKED CONTENT This article is linked to Tian et al and Tian and Rong papers. To view these articles, visit https://doi.org/10.1111/apt.15731 and https://doi.org/10.1111/apt.15986

Published
2020
Full Text
View/download PDF

17. Secondary Atrophic Rhinitis: Autoimmune and Granulomatous Forms

Author

Andrea Zoli, Angelo Zoli, Laura Gigante, and Pier Giorgio Giacomini

Subjects
medicine.medical_specialty, Tuberculosis, business.industry, Nasal congestion, medicine.disease, Dermatology, Settore MED/01, Mucous membrane pemphigoid, otorhinolaryngologic diseases, Etiology, Medicine, Syphilis, Medical history, Sarcoidosis, medicine.symptom, business, Granulomatosis with polyangiitis
Abstract

Atrophic rhinitis is characterized by progressive nasal mucosal atrophy, nasal crusting, fetor, and enlargement of the nasal space with paradoxical nasal congestion. Among diseases responsible of secondary atrophic rhinitis, infective- and noninfective-granulomatous and autoimmune diseases may be advocated, even if they represent less than 1% of etiologies. This group of pathologies should be considered especially in patients without medical history of nasal surgery or radiation and in presence of systemic symptoms, such as low-grade fever, weight loss, and arthralgias. The most frequent autoimmune diseases resulting in atrophic rhinitis are granulomatosis with polyangiitis, sarcoidosis, and mucous membrane pemphigoid. Among granulomatous infections, tuberculosis and syphilis are the leading reported causes of this group of rhinosinusitis. In this chapter, we review the main autoimmune and granulomatous causes of atrophic rhinitis focusing on ENT and systemic clinical aspects and systemic therapies.

Published
2020

18. Psychological Distress After Covid-19 Recovery: Reciprocal Effects With Temperament and Emotional Dysregulation. An Exploratory Study of Patients Over 60 Years of Age Assessed in a Post-acute Care Service

Author

Janiri, D., Kotzalidis, G. D., Giuseppin, G., Molinaro, M., Modica, Marco, Montanari, Silvia, Terenzi, Beatrice, Carfi, A., Landi, Francesco, Sani, Gabriele, rancesco Landi, Elisa Gremese, Roberto Bernabei, Massimo Fantoni, Gasbarrini, Antonio, Settanni, Carlo Romano, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfi', Angelo, Ciciarello, Francesca, Rita, M., Lo Monaco, Andrea, Martone, Anna Maria, Marzetti, Emanuele, Carmennapolitano, Pagano, Francesco Cosimo, Rocchi, Sara, Elisabettarota, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Anna, Picca, Savera, Giulia, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Simona Di Gianbenedetto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Davide, Moschese, Arturo, Ciccullo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Grazia Maria Cozzupoli, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, D'Alatri, Lucia, Crudo, Fabrizio, Giovanni Di Cintio, Longobardi, Ylenia, Laura, Tricarico, Santantonio, Mariaconsiglia, Buonsenso, Danilo, Valentini, Piero, Davide, Pata, Sinatti, Dario, De Rose, Cristina, Richeldi, Luca, Lombardi, Francesco, Angelo, Calabrese, Delfina, Janiri, Giulia, Giuseppin, Marzia, Molinaro, Natale, Luigi, Annrita, Larici, Marano, Riccardo, Annamaria, Paglionico, Petricca, Luca, Laura, Gigante, Gerlando, Natalello, Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Alivernini, Stefano, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Valentina, Popolla, Mari, Giorgia, Marchese, Maria Raffaella, and Ausili Cefaro, Carolina

Subjects
Affective temperaments, Coronavirus disease 2019 (COVID-19), lcsh:RC435-571, media_common.quotation_subject, Exploratory research, Disease, 03 medical and health sciences, 0302 clinical medicine, psychological distress, lcsh:Psychiatry, Medicine, emotional dysregulation, Original Research, media_common, affective temperaments, Psychiatry, nasal swab, business.industry, Settore MED/30 - MALATTIE APPARATO VISIVO, aging, Settore MED/09 - MEDICINA INTERNA, Psychological distress, COVID-19, Emotional dysregulation, Mental health, nasopharyngeal swab, 030227 psychiatry, Psychiatry and Mental health, Temperament, business, 030217 neurology & neurosurgery, Clinical psychology
Abstract

To study the long-term psychological effects of Covid-19 disease, we recruited 61 patients older than 60 years of age and administered the Kessler questionnaire K10 to assess psychological distress and classify them according to mental health risk groups. Patients' affective temperaments were assessed with the 39-item form of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS-A-39) and emotional dysregulation with the Difficulties in Emotion Regulation Scale (DERS). Patients were divided in two samples according to their scores on the K10, i.e., a high likelihood of psychological distress group (N = 18) and a low likelihood of psychological distress group (N = 43). The two groups differed on their gender composition, in that more women (N = 11) were in the former and more men in the latter (N = 29) (χ2 = 4.28; p = 0.039). The high likelihood of psychological distress group scored higher on the Cyclothymic (3.39 ± 3.45 vs. 0.93 ± 1.08, p < 0.001) and the Depressive (2.28 ± 2.82 vs. 0.65 ± 1.09, p = 0.01) affective temperaments of the TEMPS and on the lack of Impulse control (12.67 ± 4.04 vs. 9.63 ± 3.14, p = 0.003) and lack of Clarity (15.00 ± 5.56 vs. 9.85 ± 4.67, p = 0.004) scales of the DERS. Our results show that having had Covid-19 may be related with high likelihood for psychological distress in advanced-age people and this may in turn be associated with impaired emotional regulation and higher scores on depressive and cyclothymic temperaments.

Published
2020

19. COVID-19 and intestinal inflammation: Role of fecal calprotectin

Author

Veronica Ojetti, Angela Saviano, Marcello Covino, Nicola Acampora, Eliana Troiani, Francesco Franceschi, Valeria Abbate, Giovanni Addolorato, Fabiana Agostini, Maria Elena Ainora, Karim Akacha, Elena Amato, Francesca Andreani, Gloria Andriollo, Maria Giuseppina Annetta, Brigida Eleonora Annicchiarico, Mariangela Antonelli, Gabriele Antonucci, Gian Marco Anzellotti, Alessandro Armuzzi, Fabiana Baldi, Ilaria Barattucci, Christian Barillaro, Fabiana Barone, Rocco Domenico Alfonso Bellantone, Andrea Bellieni, Giuseppe Bello, Andrea Benicchi, Francesca Benvenuto, Ludovica Berardini, Filippo Berloco, Roberto Bernabei, Antonio Bianchi, Daniele Guerino Biasucci, Luigi Marzio Biasucci, Stefano Bibbò, Alessandra Bini, Alessandra Bisanti, Federico Biscetti, Maria Grazia Bocci, Nicola Bonadia, Filippo Bongiovanni, Alberto Borghetti, Giulia Bosco, Silvia Bosello, Vincenzo Bove, Giulia Bramato, Vincenzo Brandi, Teresa Bruni, Carmine Bruno, Dario Bruno, Maria Chiara Bungaro, Alessandro Buonomo, Livia Burzo, Angelo Calabrese, Maria Rosaria Calvello, Andrea Cambieri, Chiara Cambise, Giulia Cammà, Marcello Candelli, Gennaro Canistro, Antonello Cantanale, Gennaro Capalbo, Lorenzo Capaldi, Emanuele Capone, Esmeralda Capristo, Luigi Carbone, Silvia Cardone, Simone Carelli, Angelo Carfì, Annamaria Carnicelli, Cristiano Caruso, Francesco Antonio Casciaro, Lucio Catalano, Roberto Cauda, Andrea Leonardo Cecchini, Lucia Cerrito, Melania Cesarano, Annalisa Chiarito, Rossella Cianci, Sara Cicchinelli, Arturo Ciccullo, Marta Cicetti, Francesca Ciciarello, Antonella Cingolani, Maria Camilla Cipriani, Maria Ludovica Consalvo, Gaetano Coppola, Giuseppe Maria Corbo, Andrea Corsello, Federico Costante, Matteo Costanzi, Davide Crupi, Salvatore Lucio Cutuli, Stefano D'Addio, Alessia D'Alessandro, Maria ElenaEmanuela D'AlfonsoD'Angelo, Francesca D'Aversa, Fernando Damiano, Gian Maria De Berardinis, Tommaso De Cunzo, Donati Katleen De Gaetano, Giulio De Luca, Giuseppe De Matteis, Gennaro De Pascale, Paolo De Santis, Martina De Siena, Francesco De Vito, Valeria Del Gatto, Paola Del Giacomo, Fabio Del Zompo, Antonio Maria Dell'Anna, Davide Della Polla, Luca Di Gialleonardo, Simona Di Giambenedetto, Roberta Di Luca, Luca Di Maurizio, Mariangela Di Muro, Alex Dusina, Davide Eleuteri, Alessandra Esperide, Daniele Fachechi, Domenico Faliero, Cinzia Falsiroli, Massimo Fantoni, Annalaura Fedele, Daniela Feliciani, Cristina Ferrante, Giuliano Ferrone, Rossano Festa, Maria Chiara Fiore, Andrea Flex, Evelina Forte, Alessandra Francesconi, Laura Franza, Barbara Funaro, Mariella Fuorlo, Domenico Fusco, Maurizio Gabrielli, Eleonora Gaetani, Claudia Galletta, Antonella Gallo, Giovanni Gambassi, Matteo Garcovich, Antonio Gasbarrini, Irene Gasparrini, Silvia Gelli, Antonella Giampietro, Laura Gigante, Gabriele Giuliano, Giorgia Giuliano, Bianca Giupponi, Elisa Gremese, Domenico Luca Grieco, Manuel Guerrera, Valeria Guglielmi, Caterina Guidone, Antonio Gullì, Amerigo Iaconelli, Aurora Iafrati, Gianluca Ianiro, Angela Iaquinta, Michele Impagnatiello, Riccardo Inchingolo, Enrica Intini, Raffaele Iorio, Immacolata Maria Izzi, Tamara Jovanovic, Cristina Kadhim, Rosa La Macchia, Daniele Ignazio La Milia, Francesco Landi, Giovanni Landi, Rosario Landi, Raffaele Landolfi, Massimo Leo, Paolo Maria Leone, Laura Levantesi, Antonio Liguori, Rosa Liperoti, Marco Maria Lizzio, Maria Rita Lo Monaco, Pietro Locantore, Francesco Lombardi, Gianmarco Lombardi, Loris Lopetuso, Valentina Loria, Angela Raffaella Losito, Mothanje Barbara Patricia Lucia, Francesco Macagno, Noemi Macerola, Giampaolo Maggi, Giuseppe Maiuro, Francesco Mancarella, Francesca Mangiola, Alberto Manno, Debora Marchesini, Gian Marco Maresca, Giuseppe Marrone, Ilaria Martis, Anna Maria Martone, Emanuele Marzetti, Chiara Mattana, Maria Valeria Matteo, Riccardo Maviglia, Ada Mazzarella, Carmen Memoli, Luca Miele, Alessio Migneco, Irene Mignini, Alessandro Milani, Domenico Milardi, Massimo Montalto, Giuliano Montemurro, Flavia Monti, Luca Montini, Tony Christian Morena, Vincenzina Morra, Chiara Morretta, Davide Moschese, Celeste Ambra Murace, Martina Murdolo, Rita Murri, Marco Napoli, Elisabetta Nardella, Gerlando Natalello, Daniele Natalini, Simone Maria Navarra, Antonio Nesci, Alberto Nicoletti, Rocco Nicoletti, Tommaso Filippo Nicoletti, Rebecca Nicolò, Nicola Nicolotti, Enrico Celestino Nista, Eugenia Nuzzo, Marco Oggiano, Francesco Cosimo Pagano, Gianfranco Paiano, Cristina Pais, Federico Pallavicini, Andrea Palombo, Federico Paolillo, Alfredo Papa, Domenico Papanice, Luigi Giovanni Papparella, Mattia Paratore, Giuseppe Parrinello, Giuliana Pasciuto, Pierpaolo Pasculli, Giovanni Pecorini, Simone Perniola, Erika Pero, Luca Petricca, Martina Petrucci, Chiara Picarelli, Andrea Piccioni, Annalisa Piccolo, Edoardo Piervincenzi, Giulia Pignataro, Raffaele Pignataro, Gabriele Pintaudi, Luca Pisapia, Marco Pizzoferrato, Fabrizio Pizzolante, Roberto Pola, Caterina Policola, Maurizio Pompili, Flavia Pontecorvi, Valerio Pontecorvi, Francesca Ponziani, Valentina Popolla, Enrica Porceddu, Angelo Porfidia, Lucia Maria Porro, Annalisa Potenza, Francesca Pozzana, Giuseppe Privitera, Daniela Pugliese, Gabriele Pulcini, Simona Racco, Francesca Raffaelli, Vittoria Ramunno, Gian Ludovico Rapaccini, Luca Richeldi, Emanuele Rinninella, Sara Rocchi, Bruno Romanò, Stefano Romano, Federico Rosa, Laura Rossi, Raimondo Rossi, Enrica Rossini, Elisabetta Rota, Fabiana Rovedi, Carlotta Rubino, Gabriele Rumi, Andrea Russo, Luca Sabia, Andrea Salerno, Sara Salini, Lucia Salvatore, Dehara Samori, Claudio Sandroni, Maurizio Sanguinetti, Luca Santarelli, Paolo Santini, Danilo Santolamazza, Angelo Santoliquido, Francesco Santopaolo, Michele Cosimo Santoro, Francesco Sardeo, Caterina Sarnari, Luisa Saviano, Franco Scaldaferri, Roberta Scarascia, Tommaso Schepis, Francesca Schiavello, Giancarlo Scoppettuolo, Davide Sedda, Flaminio Sessa, Luisa Sestito, Carlo Settanni, Matteo Siciliano, Valentina Siciliano, Rossella Sicuranza, Benedetta Simeoni, Jacopo Simonetti, Andrea Smargiassi, Paolo Maurizio Soave, Chiara Sonnino, Domenico Staiti, Claudia Stella, Leonardo Stella, Eleonora Stival, Eleonora Taddei, Rossella Talerico, Elio Tamburello, Enrica Tamburrini, Eloisa Sofia Tanzarella, Elena Tarascio, Claudia Tarli, Alessandra Tersali, Pietro Tilli, Jacopo Timpano, Enrico Torelli, Flavia Torrini, Matteo Tosato, Alberto Tosoni, Luca Tricoli, Marcello Tritto, Mario Tumbarello, Anita Maria Tummolo, Maria Sole Vallecoccia, Federico Valletta, Francesco Varone, Francesco Vassalli, Giulio Ventura, Lucrezia Verardi, Lorenzo Vetrone, Giuseppe Vetrugno, Elena Visconti, Felicia Visconti, Andrea Viviani, Raffaella Zaccaria, Carmelina Zaccone, Lorenzo Zelano, Lorenzo Zileri Dal Verme, and Giuseppe Zuccalà

Subjects
Adult, Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Settore MED/12 - GASTROENTEROLOGIA, Pneumonia, Viral, Severity of Illness Index, Gastroenterology, Betacoronavirus, Feces, Intestinal mucosa, Intestinal inflammation, Internal medicine, Settore MED/41 - ANESTESIOLOGIA, medicine, Humans, Viral, Intestinal Mucosa, Letter to the Editor, Pandemics, Leukocyte L1 Antigen Complex, Hepatology, SARS-CoV-2, business.industry, Settore MED/09 - MEDICINA INTERNA, COVID-19, Pneumonia, Middle Aged, fecal calprotectin, Case-Control Studies, Female, Calprotectin, Coronavirus Infections, business, Biomarkers
Published
2020

20. Mutation analysis of the FBN1 gene in a cohort of patients with Marfan Syndrome: A 10-year single center experience

Author

Valentina Ferradini, Giovanni Ruvolo, Laura Gigante, Federica Sangiuolo, Serena Luciano, Liliana Mannucci, Chiara Conte, Nunzia Piumelli, Francesco Brancati, Giuseppe Novelli, Leila B. Salehi, and Giuliana Longo

Subjects
0301 basic medicine, Marfan syndrome, Nosology, Male, Fibrillin-1, Clinical Biochemistry, DNA Mutational Analysis, Single Center, medicine.disease_cause, Biochemistry, Marfan Syndrome, Cohort Studies, 0302 clinical medicine, skin and connective tissue diseases, Child, Aortic dissection, Mutation, High-Throughput Nucleotide Sequencing, General Medicine, Middle Aged, FBN1, Gene variants, MFS, NGS, Italy, 030220 oncology & carcinogenesis, Child, Preschool, Cohort, Female, musculoskeletal diseases, Adult, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Adolescent, macromolecular substances, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, cardiovascular diseases, Gene, business.industry, Biochemistry (medical), medicine.disease, 030104 developmental biology, Settore MED/03 - Genetica Medica, Mutation testing, business
Abstract

Background Marfan Syndrome (MFS) is a chronic, life-threatening, autosomal dominant connective tissue disorder caused by mutations in the FBN1 gene, coding for fibrillin-1. All organ systems may be affected, but particularly the cardiovascular system, eyes, and skeleton. Mortality generally results from cardiovascular complications, mainly aortic dissection. Currently, the diagnosis of MFS is based on the revised Ghent nosology. Molecular analysis of the FBN1 gene reduces diagnostic uncertainty in patients with suspected MFS or MFS-related disorders (MFS-RD). To date, more than 2700 FBN1 mutations are known. Methods Using Next Generation Sequencing (NGS) followed by Multiplex Ligation-dependent Probe Amplification on NGS-negative samples, we screened FBN1 gene on 124 unrelated patients (101 MFS fulfilling revised Ghent criteria, 20 suspected MFS, 3 MFS-RD) enrolled from 2008 to 2018 at the Multidisciplinary Marfan Clinic, Tor Vergata Hospital, Rome. Results An FBN1 variant was identified in 107/124 (86.3%) patients, including 48 novel variants (46 pathogenic/likely pathogenic, 2 VUS). A pathogenic/likely pathogenic variant was detected in 90/101 (89.1%) MFS patients. Our approach allowed early diagnosis for 10 young patients (age 3–19 years) with suspected MFS. Conclusions This study broadens the mutation spectrum of FBN1, providing a full update of the molecular basis of MFS in Italy.

Published
2019

21. A (in)efetividade da audi?ncia de cust?dia no controle da viol?ncia policial : um estudo sobre a teoria e pr?tica no sistema de justi?a criminal

Author

Albuquerque, Laura Gigante and Giacomolli, Nereu Jos?

Subjects
Viol?ncia Policial, Direitos Humanos, Devido Processo Penal, DIREITO [CIENCIAS SOCIAIS APLICADAS], Audi?ncia de Cust?dia
Abstract

A viol?ncia policial ? uma das faces da viola??o sistem?tica a direitos humanos no Brasil e vem sendo denunciada por organismos internacionais, tendo sido objeto de recente condena??o do Estado brasileiro na Corte Interamericana de Direitos Humanos (Caso Favela Nova Bras?lia vs. Brasil). A realidade exige que se (re)pensem os meios de controle sobre agentes policiais e as formas de coibi??o das pr?ticas violentas. ? neste ?mbito que se insere a presente pesquisa, que tem como objeto central a audi?ncia de cust?dia, implementada no Brasil em 2015 pelo Conselho Nacional de Justi?a. A sua finalidade ? proporcionar um maior controle do trabalho policial atrav?s da apresenta??o imediata da pessoa presa ou detida a uma autoridade judicial, de forma que o seu advento poderia contribuir com o trabalho de fiscaliza??o, representando um novo canal de den?ncias aos ?rg?os de controle. A partir do substrato te?rico que vem se formando sobre a audi?ncia de cust?dia, chega-se ? pergunta-problema que norteia a pesquisa: quais s?o os reflexos da implanta??o das audi?ncias de cust?dia no controle das pr?ticas de viol?ncia policial? Analisa-se, portanto, de que forma o advento das audi?ncias de cust?dia influencia o trabalho dos ?rg?os de controle, em especial do Minist?rio P?blico, quanto ? fiscaliza??o e coibi??o da viol?ncia. Para tanto, al?m da pesquisa te?rica realizada, apresenta-se um estudo de caso da Comarca de Porto Alegre/RS, mediante pesquisa etnogr?fica, aliando a observa??o direta das audi?ncias a entrevistas e conversas informais com os atores jur?dicos nelas envolvidos, al?m do levantamento de dados quantitativos. O trabalho, desenvolvido no Programa de P?s- Gradua??o em Ci?ncias Criminais da PUCRS, insere-se na ?rea de concentra??o Sistema Penal e Viol?ncia e na linha de pesquisa Sistemas Jur?dico-Penais Contempor?neos, embora dialogue tamb?m com a linha Viol?ncia, Crime e Seguran?a P?blica, em abordagem transdisciplinar. Para al?m do importante estudo te?rico do novo instituto, pretende-se colaborar com um debate cr?tico que proporcione a implanta??o efetiva da audi?ncia de cust?dia, acompanhada por uma mudan?a de paradigma em dire??o a um processo penal humanizado. Police violence is one of the faces of the systematic violation of human rights in Brazil and has been denounced by international organizations, having been the subject of a recent condemnation of the Brazilian State in the Inter-American Court of Human Rights (Favela Nova Bras?lia v. Brazil Case). Reality demands that one (re) thinks the means of control over police agents and the ways of restraining violent practices. This is the scope of this research, which has as its central object the bail hearing, implemented in Brazil in 2015 by the National Council of Justice. Its purpose is to provide greater control of police work through the immediate presentation of the person arrested or detained to a judicial authority, so that its advent could contribute to the inspection work, representing a new channel of complaints to the control bodies. From the theoretical substrate that has been formed on the bail hearing, we arrive at the problem question that guides the investigation: what are the reflexes of the implantation of bail hearings in the control of police violence practices? It is analyzed, therefore, how the advent of bail hearings influences the work of the control organs, especially of the Public Prosecutor's Office, regarding the control and restraining of violence. In addition to the theoretical research carried out, a case study of Porto Alegre/RS is presented, through ethnographic research, combining the direct observation of the hearing with interviews and informal conversations with legal actors involved in them, as well as the gathering of quantitative data. The work, developed in the Postgraduate Program in Criminal Sciences of PUCRS, is part of the Criminal System and Violence concentration and in the line of research on Contemporary Criminal-Legal Systems, although it also deals with Violence, Crime and Public Security, in a transdisciplinary approach. In addition to the important theoretical study of the new institute, it is intended to collaborate with a critical debate that provides for the effective implementation of the bail hearing, accompanied by a paradigm shift toward a humanized criminal process. Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

Published
2018

22. 'Não me vejo na palavra fêmea, alvo de caça, conformada vítima': a insuficiência da narrativa estatal perante as demandas de violência doméstica = 'I do not see me in the word female, hunting target, conformed victim': the insufficiency of the state narrative in relation to domestic violence demands

Author

Albuquerque, Laura Gigante and Goulart, Domenique Assis

Abstract

Submitted by deniseoa@stj.jus.br (deniseoa@stj.jus.br) on 2019-01-10T16:18:03Z No. of bitstreams: 2 nao_vejo_palavra_albuquerque.pdf: 628084 bytes, checksum: 8433d70e259b75e71b6c693e089a760e (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Patrícia Rabello (rabello@stj.jus.br) on 2019-01-15T17:27:36Z (GMT) No. of bitstreams: 2 nao_vejo_palavra_albuquerque.pdf: 628084 bytes, checksum: 8433d70e259b75e71b6c693e089a760e (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2019-01-15T17:27:36Z (GMT). No. of bitstreams: 2 nao_vejo_palavra_albuquerque.pdf: 628084 bytes, checksum: 8433d70e259b75e71b6c693e089a760e (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2018

Published
2018

23. A audiência de custódia e os seus impactos no sistema de justiça criminal brasileiro = The bail hearing and its impacts on the Brazilian criminal justice system

Author

Giacomolli, Nereu José and Albuquerque, Laura Gigante

Subjects
Audiência (processo penal), Direitos primordiais do homem, Prisão, Violência policial, Sistema penal, Audiência (processo penal), aspectos constitucionais, Direitos humanos (direito internacional público), Direitos fundamentais do homem
Abstract

Submitted by Eliana null (leila@stj.jus.br) on 2018-03-27T15:33:41Z No. of bitstreams: 2 audiencia_custodia_impactos_giacomolli.pdf: 249826 bytes, checksum: 7296ac43287835e0da98e55f999c62e3 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Renata Ribeiro (rribeiro@stj.jus.br) on 2018-04-03T14:41:27Z (GMT) No. of bitstreams: 2 audiencia_custodia_impactos_giacomolli.pdf: 249826 bytes, checksum: 7296ac43287835e0da98e55f999c62e3 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2018-04-03T14:41:27Z (GMT). No. of bitstreams: 2 audiencia_custodia_impactos_giacomolli.pdf: 249826 bytes, checksum: 7296ac43287835e0da98e55f999c62e3 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2017

Published
2017

24. Rhabdoid tumor predisposition syndrome caused by SMARCB1 constitutional deletion: prenatal detection of new case of recurrence in siblings due to gonadal mosaicism

Author

Irene Paganini, Laura Gigante, Laura Papi, Marina Frontali, Federica Sangiuolo, and Serena Ciabattoni

Subjects
Male, 0301 basic medicine, Proband, Cancer Research, Pathology, medicine.medical_specialty, Chromosomal Proteins, Non-Histone, Prenatal diagnosis, Loss of Heterozygosity, SMARCB1, Germline mosaicism, 030105 genetics & heredity, Biology, medicine.disease_cause, Rhabdoid Tumor Predisposition Syndrome, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Pregnancy, Gonadal mosaicism, Genetics, medicine, Humans, Genetic Predisposition to Disease, Germ-Line Mutation, Genetics (clinical), Mutation, 22q deletion, Brain Neoplasms, Mosaicism, Siblings, Infant, SMARCB1 Protein, Kidney Neoplasms, Human genetics, Pedigree, DNA-Binding Proteins, Oncology, Settore MED/03 - Genetica Medica, 030220 oncology & carcinogenesis, Cancer research, Female, Rhabdoid tumor, Multiplex Polymerase Chain Reaction, Transcription Factors
Abstract

Rhabdoid tumors are aggressive malignancies that show loss-of-function mutations of SMARCB1 gene, a member of the SWI/SNF chromatin-remodeling complex controlling gene transcription. One-third of patients affected by rhabdoid tumor harbor a germ-line mutation of SMARCB1 defining a rhabdoid tumor predisposition syndrome. The occurrence of a second somatic mutation determines the development of neoplasia in a two-hit model. Most germ-line mutations occur de novo, and few cases of recurrence in a sibship have been described. Here we report on a new Italian family with recurrence of SMARCB1 germ-line deletion in two siblings due to gonadal mosaicism. The deletion was identified in the 9-month-old proband with malignant rhabdoid tumor of the right kidney and disseminated metastases. Testing of both parents confirmed the de novo origin of the mutation, but recurrence was then detected prenatally in a new pregnancy. This is the sixth family with malignant rhabdoid tumor predisposition syndrome with the recurrence of the same germ-line SMARCB1 mutation in the sibship but not in healthy parents, suggesting that gonadal mosaicism is a less rare event than supposed. The clinical outcome in our patient confirms previous data of poorer outcome in patients with rhabdoid tumor predisposition syndrome.

Published
2016
Full Text
View/download PDF

26. Crimes sexuais na ditadura civil-militar brasileira (1964-1985): perspectivas da violências institucional e de gênero

Author

Rosa Maria Zaia Borges, Simone Schuck da Silva, and Laura Gigante Albuquerque

Abstract

O artigo busca contextualizar as possiveis formas de abordar os crimes sexuais cometidos durante a ditadura civil-militar iniciada no Brasil em 1964. Considerando a importância do reconhecimento destes crimes como parte da violencia estatal e institucional praticada, propoe-se a sua complementacao a partir de uma perspectiva de genero. Desde os aportes da criminologia feminista, o artigo questiona a universalizacao dos mecanismos utilizados para investigar os crimes cometidos durante o periodo ditatorial, chama a atencao para a possibilidade (inaceitavel, porem possivel) de revitimizacao a partir da inadequacao desses metodos e convoca ao desvelamento do posicionamento ideologico do Estado nas violencias sexual e de genero. O objetivo do artigo, assim, e questionar a necessaria, porem insuficiente perspectiva tradicional de tratamento dos crimes sexuais cometidos durante o periodo, reafirmando seu aspecto de violencia institucional, de responsabilidade do Estado, mas considerando a perspectiva de genero, a fim de possibilitar a superacao de vulnerabilidades historicas.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results