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1. Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Author

Nadiya, Byts, Subodh, Sharma, Tarja, Malm, Mika, Kaakinen, Paula, Korhonen, Laura, Jaakkonen, Meike, Keuters, Mikko, Huuskonen, Ilkka, Pietilä, Jari, Koistinaho, Peppi, Koivunen, and Johanna, Myllyharju

Subjects
Stroke, Vascular Endothelial Growth Factor A, Mice, Cell Membrane Permeability, Blood-Brain Barrier, Neuroinflammatory Diseases, Animals, Infarction, Middle Cerebral Artery, Prolyl-Hydroxylase Inhibitors, Hypoxia-Inducible Factor 1, alpha Subunit, Permeability, Prolyl Hydroxylases
Abstract

Hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs) regulate the hypoxic induction of300 genes required for survival and adaptation under oxygen deprivation. Inhibition of HIF-P4H-2 has been shown to be protective in focal cerebral ischemia rodent models, while that of HIF-P4H-1 has no effects and inactivation of HIF-P4H-3 has adverse effects. A transmembrane prolyl 4-hydroxylase (P4H-TM) is highly expressed in the brain and contributes to the regulation of HIF, but the outcome of its inhibition on stroke is yet unknown. To study this, we subjected WT and P4htm

Published
2021

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