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Stellar and black hole feedback heat and disperse surrounding cold gas clouds, launching gas flows off circumnuclear and galactic disks, producing a dynamic interstellar medium. On large scales bordering the cosmic web, feedback drives enriched gas out of galaxies and groups, seeding the intergalactic medium with heavy elements. In this way, feedback shapes galaxy evolution by shutting down star formation and ultimately curtailing the growth of structure after the peak at redshift 2–3. To understand the complex interplay between gravity and feedback, we must resolve both the key physics within galaxies and map the impact of these processes over large scales, out into the cosmic web. The Advanced X-ray Imaging Satellite (AXIS) is a proposed X-ray probe mission for the 2030s with arcsecond spatial resolution, large effective area, and low background. AXIS will untangle the interactions of winds, radiation, jets, and supernovae with the surrounding interstellar medium across the wide range of mass scales and large volumes driving galaxy evolution and trace the establishment of feedback back to the main event at cosmic noon. This white paper is part of a series commissioned for the AXIS Probe mission concept; additional AXIS white papers can be found at the AXIS website.

We present a statistical analysis of the local, ≈50–100 pc scale, H α emission at the locations of recent (≤125 yr) supernovae (SNe) in nearby star-forming galaxies. Our sample consists of 32 SNe in 10 galaxies that are targets of the PHANGS-MUSE survey. We find that 41% (13/32) of these SNe occur coincident with a previously identified H ii region. For comparison, H ii regions cover 32% of the area within ±1 kpc of any recent SN. Contrasting this local covering fraction with the fraction of SNe coincident with H ii regions, we find a statistical excess of 7.6% ± 8.7% of all SNe to be associated with H ii regions. This increases to an excess of 19.2% ± 10.4% when considering only core-collapse SNe (CCSNe). These estimates appear to be in good agreement with qualitative results from new, higher-resolution Hubble Space Telescope H α imaging, which also suggests many CCSNe detonate near but not in H ii regions. Our results appear consistent with the expectation that only a modest fraction of stars explode during the first ≲5 Myr of the life of a stellar population when H α emission is expected to be bright. Of the H ii region associated SNe, 85% (11/13) also have associated detected CO (2–1) emission, indicating the presence of molecular gas. The SNe associated with H ii regions have typical extinctions of A _V ∼ 1 mag, consistent with a significant amount of pre-clearing of gas from the region before the SNe explode.

We analyze 330 ks of Chandra X-ray imaging and spectra of the nearby, edge-on starburst and Seyfert type 2 galaxy NGC 4945 to measure the hot gas properties along the galactic outflows. We extract and model spectra from 15 regions extending from −0.55 to +0.85 kpc above and below the galactic disk to determine the best-fit parameters and metal abundances. We find that the hot gas temperatures and number densities peak in the central regions and decrease along the outflows. These profiles are inconsistent with a spherical, adiabatically expanding wind model, suggesting the need to include mass loading and/or a nonspherical outflow geometry. We estimate the mass outflow rate of the hot wind to be 1.6 M _⊙ yr ^−1 . Emission from charge exchange is detected in the northern outflow, and we estimate it contributes 12% to the emitted, broadband (0.5–7 keV) X-ray flux.

We present new observations of the central 1 kpc of the M82 starburst obtained with the James Webb Space Telescope near-infrared camera instrument at a resolution θ ∼ 0.″05–0.″1 (∼1–2 pc). The data comprises images in three mostly continuum filters (F140M, F250M, and F360M), and filters that contain [Fe ii ] (F164N), H _2 v = 1 → 0 (F212N), and the 3.3 μ m polycyclic aromatic hydrocarbon (PAH) feature (F335M). We find prominent plumes of PAH emission extending outward from the central starburst region, together with a network of complex filamentary substructures and edge-brightened bubble-like features. The structure of the PAH emission closely resembles that of the ionized gas, as revealed in Paschen α and free–free radio emission. We discuss the origin of the structure, and suggest the PAHs are embedded in a combination of neutral, molecular, and photoionized gas.

We present the Physics at High Angular resolution in Nearby GalaxieS (PHANGS)-AstroSat atlas, which contains UV imaging of 31 nearby star-forming galaxies captured by the Ultraviolet Imaging Telescope on the AstroSat satellite. The atlas provides a homogeneous data set of far-UV and near-UV maps of galaxies within a distance of 22 Mpc and a median angular resolution of 1.″4 (corresponding to a physical scale between 25 and 160 pc). After subtracting a uniform UV background and accounting for Milky Way extinction, we compare our estimated flux densities to GALEX observations, finding good agreement. We find candidate extended UV disks around the galaxies NGC 6744 and IC 5332. We present the first statistical measurements of the clumping of the UV emission and compare it to the clumping of molecular gas traced with the Atacama Large Millimeter/submillimeter Array (ALMA). We find that bars and spiral arms exhibit the highest degree of clumping, and the molecular gas is even more clumped than the far-UV (FUV) emission in galaxies. We investigate the variation of the ratio of observed FUV to H α in different galactic environments and kiloparsec-sized apertures. We report that ∼65% of the variation of the log _10 (FUV/H α ) can be described through a combination of dust attenuation with star formation history parameters. The PHANGS-AstroSat atlas enhances the multiwavelength coverage of our sample, offering a detailed perspective on star formation. When integrated with PHANGS data sets from ALMA, the Very Large Telescope-MUSE, the Hubble Space Telescope, and JWST, it develops our comprehensive understanding of attenuation curves and dust attenuation in star-forming galaxies.

The first JWST observations of nearby galaxies have unveiled a rich population of bubbles that trace the stellar-feedback mechanisms responsible for their creation. Studying these bubbles therefore allows us to chart the interaction between stellar feedback and the interstellar medium, and the larger galactic flows needed to regulate star formation processes globally. We present the first catalog of bubbles in NGC 628, visually identified using Mid-Infrared Instrument F770W Physics at High Angular resolution in Nearby GalaxieS (PHANGS)–JWST observations, and use them to statistically evaluate bubble characteristics. We classify 1694 structures as bubbles with radii between 6 and 552 pc. Of these, 31% contain at least one smaller bubble at their edge, indicating that previous generations of star formation have a local impact on where new stars form. On large scales, most bubbles lie near a spiral arm, and their radii increase downstream compared to upstream. Furthermore, bubbles are elongated in a similar direction to the spiral-arm ridgeline. These azimuthal trends demonstrate that star formation is intimately connected to the spiral-arm passage. Finally, the bubble size distribution follows a power law of index p = −2.2 ± 0.1, which is slightly shallower than the theoretical value by 1–3.5 σ that did not include bubble mergers. The fraction of bubbles identified within the shells of larger bubbles suggests that bubble merging is a common process. Our analysis therefore allows us to quantify the number of star-forming regions that are influenced by an earlier generation, and the role feedback processes have in setting the global star formation rate. With the full PHANGS–JWST sample, we can do this for more galaxies.

We compare embedded young massive star clusters (YMCs) to (sub-)millimeter line observations tracing the excitation and dissociation of molecular gas in the starburst ring of NGC 1365. This galaxy hosts one of the strongest nuclear starbursts and richest populations of YMCs within 20 Mpc. Here we combine near-/mid-IR PHANGS–JWST imaging with new Atacama Large Millimeter/submillimeter Array multi- J CO (1–0, 2–1 and 4–3) and [ C i ] (1–0) mapping, which we use to trace CO excitation via R _42 = I _CO(4−3) / I _CO(2−1) and R _21 = I _CO(2−1) / I _CO(1−0) and dissociation via R _CICO = I _[CI](1−0) / I _CO(2−1) at 330 pc resolution. We find that the gas flowing into the starburst ring from northeast to southwest appears strongly affected by stellar feedback, showing decreased excitation (lower R _42 ) and increased signatures of dissociation (higher R _CICO ) in the downstream regions. There, radiative-transfer modeling suggests that the molecular gas density decreases and temperature and [CI/CO] abundance ratio increase. We compare R _42 and R _CICO with local conditions across the regions and find that both correlate with near-IR 2 μ m emission tracing the YMCs and with both polycyclic aromatic hydrocarbon (11.3 μ m) and dust continuum (21 μ m) emission. In general, R _CICO exhibits ∼0.1 dex tighter correlations than R _42 , suggesting C i to be a more sensitive tracer of changing physical conditions in the NGC 1365 starburst than CO (4–3). Our results are consistent with a scenario where gas flows into the two arm regions along the bar, becomes condensed/shocked, forms YMCs, and then these YMCs heat and dissociate the gas.

The PHANGS collaboration has been building a reference data set for the multiscale, multiphase study of star formation and the interstellar medium (ISM) in nearby galaxies. With the successful launch and commissioning of JWST, we can now obtain high-resolution infrared imaging to probe the youngest stellar populations and dust emission on the scales of star clusters and molecular clouds (∼5–50 pc). In Cycle 1, PHANGS is conducting an eight-band imaging survey from 2 to 21 μ m of 19 nearby spiral galaxies. Optical integral field spectroscopy, CO(2–1) mapping, and UV-optical imaging for all 19 galaxies have been obtained through large programs with ALMA, VLT-MUSE, and Hubble. PHANGS–JWST enables a full inventory of star formation, accurate measurement of the mass and age of star clusters, identification of the youngest embedded stellar populations, and characterization of the physical state of small dust grains. When combined with Hubble catalogs of ∼10,000 star clusters, MUSE spectroscopic mapping of ∼20,000 H ii regions, and ∼12,000 ALMA-identified molecular clouds, it becomes possible to measure the timescales and efficiencies of the earliest phases of star formation and feedback, build an empirical model of the dependence of small dust grain properties on local ISM conditions, and test our understanding of how dust-reprocessed starlight traces star formation activity, all across a diversity of galactic environments. Here we describe the PHANGS–JWST Treasury survey, present the remarkable imaging obtained in the first few months of science operations, and provide context for the initial results presented in the first series of PHANGS–JWST publications.

We present a high-resolution view of bubbles within the Phantom Galaxy (NGC 628), a nearby (∼10 Mpc), star-forming (∼2 M _⊙ yr ^−1 ), face-on ( i ∼ 9°) grand-design spiral galaxy. With new data obtained as part of the Physics at High Angular resolution in Nearby GalaxieS (PHANGS)-JWST treasury program, we perform a detailed case study of two regions of interest, one of which contains the largest and most prominent bubble in the galaxy (the Phantom Void, over 1 kpc in diameter), and the other being a smaller region that may be the precursor to such a large bubble (the Precursor Phantom Void). When comparing to matched-resolution H α observations from the Hubble Space Telescope, we see that the ionized gas is brightest in the shells of both bubbles, and is coincident with the youngest (∼1 Myr) and most massive (∼10 ^5 M _⊙ ) stellar associations. We also find an older generation (∼20 Myr) of stellar associations is present within the bubble of the Phantom Void. From our kinematic analysis of the H I , H _2 (CO), and H ii gas across the Phantom Void, we infer a high expansion speed of around 15 to 50 km s ^−1 . The large size and high expansion speed of the Phantom Void suggest that the driving mechanism is sustained stellar feedback due to multiple mechanisms, where early feedback first cleared a bubble (as we observe now in the Precursor Phantom Void), and since then supernovae have been exploding within the cavity and have accelerated the shell. Finally, comparison to simulations shows a striking resemblance to our JWST observations, and suggests that such large-scale, stellar-feedback-driven bubbles should be common within other galaxies.

We present maps of the 3.3 μ m polycyclic aromatic hydrocarbon (PAH) emission feature in NGC 628, NGC 1365, and NGC 7496 as observed with the Near-Infrared Camera imager on JWST from the PHANGS–JWST Cycle 1 Treasury project. We create maps that isolate the 3.3 μ m PAH feature in the F335M filter (F335M _PAH ) using combinations of the F300M and F360M filters for removal of starlight continuum. This continuum removal is complicated by contamination of the F360M by PAH emission and variations in the stellar spectral energy distribution slopes between 3.0 and 3.6 μ m. We modify the empirical prescription from Lai et al. to remove the starlight continuum in our highly resolved galaxies, which have a range of starlight- and PAH-dominated lines of sight. Analyzing radially binned profiles of the F335M _PAH emission, we find that between 5% and 65% of the F335M intensity comes from the 3.3 μ m feature within the inner 0.5 r _25 of our targets. This percentage systematically varies from galaxy to galaxy and shows radial trends within the galaxies related to each galaxy’s distribution of stellar mass, interstellar medium, and star formation. The 3.3 μ m emission is well correlated with the 11.3 μ m PAH feature traced with the MIRI F1130W filter, as is expected, since both features arise from C–H vibrational modes. The average F335M _PAH /F1130W ratio agrees with the predictions of recent models by Draine et al. for PAHs with size and charge distributions shifted toward larger grains with normal or higher ionization.

JWST observations of polycyclic aromatic hydrocarbon (PAH) emission provide some of the deepest and highest resolution views of the cold interstellar medium (ISM) in nearby galaxies. If PAHs are well mixed with the atomic and molecular gas and illuminated by the average diffuse interstellar radiation field, PAH emission may provide an approximately linear, high-resolution, high-sensitivity tracer of diffuse gas surface density. We present a pilot study that explores using PAH emission in this way based on Mid-Infrared Instrument observations of IC 5332, NGC 628, NGC 1365, and NGC 7496 from the Physics at High Angular resolution in Nearby GalaxieS-JWST Treasury. Using scaling relationships calibrated in Leroy et al., scaled F1130W provides 10–40 pc resolution and 3 σ sensitivity of Σ _gas ∼ 2 M _⊙ pc ^−2 . We characterize the surface densities of structures seen at

We compare mid-infrared (mid-IR), extinction-corrected H α , and CO (2–1) emission at 70–160 pc resolution in the first four PHANGS–JWST targets. We report correlation strengths, intensity ratios, and power-law fits relating emission in JWST’s F770W, F1000W, F1130W, and F2100W bands to CO and H α . At these scales, CO and H α each correlate strongly with mid-IR emission, and these correlations are each stronger than the one relating CO to H α emission. This reflects that mid-IR emission simultaneously acts as a dust column density tracer, leading to a good match with the molecular-gas-tracing CO, and as a heating tracer, leading to a good match with the H α . By combining mid-IR, CO, and H α at scales where the overall correlation between cold gas and star formation begins to break down, we are able to separate these two effects. We model the mid-IR above I _ν = 0.5 MJy sr ^−1 at F770W, a cut designed to select regions where the molecular gas dominates the interstellar medium (ISM) mass. This bright emission can be described to first order by a model that combines a CO-tracing component and an H α -tracing component. The best-fitting models imply that ∼50% of the mid-IR flux arises from molecular gas heated by the diffuse interstellar radiation field, with the remaining ∼50% associated with bright, dusty star-forming regions. We discuss differences between the F770W, F1000W, and F1130W bands and the continuum-dominated F2100W band and suggest next steps for using the mid-IR as an ISM tracer.

We present new 0.3–21 μ m photometry of SN 2021aefx in the spiral galaxy NGC 1566 at +357 days after B -band maximum, including the first detection of any Type Ia supernova (SN Ia) at >15 μ m. These observations follow earlier JWST observations of SN 2021aefx at +255 days after the time of maximum brightness, allowing us to probe the temporal evolution of the emission properties. We measure the fraction of flux emerging at different wavelengths and its temporal evolution. Additionally, the integrated 0.3–14 μ m decay rate of Δ m _0.3–14 = 1.35 ± 0.05 mag/100 days is higher than the decline rate from the radioactive decay of ^56 Co of ∼1.2 mag/100 days. The most plausible explanation for this discrepancy is that flux is shifting to >14 μ m, and future JWST observations of SNe Ia will be able to directly test this hypothesis. However, models predicting nonradiative energy loss cannot be excluded with the present data.

High-resolution JWST-MIRI images of nearby spiral galaxies reveal emission with complex substructures that trace dust heated both by massive young stars and the diffuse interstellar radiation field. We present high angular (0.″85) and physical resolution (20–80 pc) measurements of the probability distribution function (PDF) of mid-infrared (mid-IR) emission (7.7–21 μ m) from 19 nearby star-forming galaxies from the PHANGS-JWST Cycle 1 Treasury. The PDFs of mid-IR emission from the disks of all 19 galaxies consistently show two distinct components: an approximately lognormal distribution at lower intensities and a high-intensity power law component. These two components only emerge once individual star-forming regions are resolved. Comparing with locations of H ii regions identified from Very Large Telescope/MUSE H α mapping, we infer that the power-law component arises from star-forming regions and thus primarily traces dust heated by young stars. In the continuum-dominated 21 μ m band, the power law is more prominent and contains roughly half of the total flux. At 7.7–11.3 μ m, the power law is suppressed by the destruction of small grains (including PAHs) close to H ii regions, while the lognormal component tracing the dust column in diffuse regions appears more prominent. The width and shape of the lognormal diffuse emission PDFs in galactic disks remain consistent across our sample, implying a lognormal gas column density N (H) ≈ 10 ^21 cm ^−2 shaped by supersonic turbulence with typical (isothermal) turbulent Mach numbers ≈5−15. Finally, we describe how the PDFs of galactic disks are assembled from dusty H ii regions and diffuse gas and discuss how the measured PDF parameters correlate with global properties such as star formation rate and gas surface density.

The exact origins of many Type Ia supernovae—progenitor scenarios and explosive mechanisms—remain uncertain. In this work, we analyze the global Suzaku X-ray spectrum of Kepler’s supernova remnant (SNR) in order to constrain the mass ratios of various ejecta species synthesized during explosion. Critically, we account for the Suzaku telescope effective-area calibration uncertainties of 5%–20% by generating 100 mock effective-area curves and using Markov Chain Monte Carlo–based spectral fitting to produce 100 sets of best-fit parameter values. Additionally, we characterize the uncertainties from assumptions made about the emitting volumes of each model plasma component and find that these uncertainties can be the dominant source of error. We then compare our calculated mass ratios to previous observational studies of Kepler’s SNR and to the predictions of Type Ia simulations. Our mass ratio estimates require a 90% attenuated ^12 C+ ^16 O reaction rate and are potentially consistent with both near- and sub- M _Ch progenitors, but are inconsistent with the dynamically stable double-detonation origin scenario and only marginally consistent with the dynamically unstable dynamically driven double-degenerate double-detonation (D ^6 ) scenario.

We analyze image and spectral data from ≈365 ks of observations from the Chandra X-ray Observatory of the nearby, edge-on starburst galaxy NGC 253 to constrain properties of the hot phase of the outflow. We focus our analysis on the −1.1 to +0.63 kpc region of the outflow and define several regions for spectral extraction where we determine best-fit temperatures and metal abundances. We find that the temperatures and electron densities peak in the central ∼250 pc region of the outflow and decrease with distance. These temperature and density profiles are in disagreement with an adiabatic spherically expanding starburst wind model and suggest the presence of additional physics such as mass loading and nonspherical outflow geometry. Our derived temperatures and densities yield cooling times in the nuclear region of a few million years, which may imply that the hot gas can undergo bulk radiative cooling as it escapes along the minor axis. Our metal abundances of O, Ne, Mg, Si, S, and Fe all peak in the central region and decrease with distance along the outflow, with the exception of Ne, which maintains a flat distribution. The metal abundances indicate significant dilution outside of the starburst region. We also find estimates of the mass outflow rates, which are 2.8 M _⊙ yr ^−1 in the northern outflow and 3.2 M _⊙ yr ^−1 in the southern outflow. Additionally, we detect emission from charge exchange and find it makes a significant contribution (20%–42%) to the total broadband (0.5–7 keV) X-ray emission in the central and southern regions of the outflow.

We measure the molecular gas environment near recent (

Abstract Ewing sarcoma is the second most common pediatric bone and soft tissue tumor presenting with an aggressive behavior and prevalence to metastasize. The diagnostic translocation t(22;11)(q24;12) leads to expression of the chimeric oncoprotein EWS-FLI1 which is uniquely expressed in all tumor cells and maintains their survival. Constant EWS-FLI1 protein turnover is regulated by the ubiquitin proteasome system. Here, we now identified ubiquitin specific protease 19 (USP19) as a regulator of EWS-FLI1 stability using an siRNA based screening approach. Depletion of USP19 resulted in diminished EWS-FLI1 protein levels and, vice versa, upregulation of active USP19 stabilized the fusion protein. Importantly, stabilization appears to be specific for the fusion protein as it could not be observed neither for EWSR1 nor for FLI1 wild type proteins even though USP19 binds to the N-terminal EWS region to regulate deubiquitination of both EWS-FLI1 and EWSR1. Further, stable shUSP19 depletion resulted in decreased cell growth and diminished colony forming capacity in vitro, and significantly delayed tumor growth in vivo. Our findings not only provide novel insights into the importance of the N-terminal EWSR1 domain for regulation of fusion protein stability, but also indicate that inhibition of deubiquitinating enzyme(s) might constitute a novel therapeutic strategy in treatment of Ewing sarcoma.

Abstract Objective The advent of ligand-based receptor capture methodologies, allows the identification of unknown receptor candidates for orphan extracellular ligands. However, further target validation can be tedious, laborious and time-consuming. Here, we present a methodology that provides a fast and cost-efficient alternative for candidate target verification on living cells. Results In the described methodology a ligand of interest (e.g. transferrin, epidermal growth factor or insulin) was conjugated to a linker (TriCEPS) that carries a biotin. To confirm ligand/receptor interactions, the ligand–TriCEPS conjugates were first added onto living cells and cells were subsequently labeled with a streptavidin-fluorophore and analyzed by flow cytometry (thus referred as Flow-TriCEPS). Flow-TriCEPS was also used to validate identified receptor candidates when combined with a siRNA knock down approach (i.e. reduction of expression levels). This approach is versatile as it can be applied for different classes of ligands (proteins, peptides, antibodies) and different cell lines. Moreover, the method is time-efficient since it takes advantage of the large variety of commercially available (and certified) siRNAs.

The Receptor Activator Nuclear of κB Ligand (RANKL) plays an important function in immune responses, activating osteoclast cells and unchanged bone resorption, which in turn leads to bone erosion and inflammation. Genetic variants in the promoter region of the RANKL gene could lead to a higher risk of rheumatoid arthritis (RA). Objective: To assess the association of rs9533155 (-693C>G) and rs9533156 (-643T>C) genetic variants with RA risk. Methods: A case–control study was carried out. A total of 94 patients with RA (RA group) and 134 subjects without any rheumatologic disease (control group) were included. Genetic DNA was extracted from peripheral white blood cells (leukocytes). Genetic variant rs9533155 (-693C>G) was screened by an approach based on Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP), while rs9533156 (-643T>C) was screened using quantitative polymerase chain reaction (qPCR) with TaqMan probes. RANKL serum levels were measured by ELISA. Results: For rs9533155 (-693C>G), the polymorphic homozygous genotype frequencies (CC) were higher in the RA group (p = 0.006). Individuals carrying the risk genotype presented higher levels of serum RANKL. Carriers of the polymorphic homozygous genotype in the dominant model (CC vs. CG + GG) had an increased risk of developing RA (OR: 1.8, 95% CI 1.04 to 3.1). No association between rs9533156 (-643T>C) and the haplotypes with RA risk was observed. Conclusion: The rs9533155 (-693C>G) genetic variant exhibits a potential role in RA risk. The studied population had no association with the rs9533156 (-643T>C) genetic variant. [ABSTRACT FROM AUTHOR]