Author: "Laura Porta" - Searchworks@Jio Institute Digital Library Search Results

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1. Analysis of cavitation artifacts in Magnetic Resonance Imaging Thermometry during laser ablation monitoring.

Author: Martina De Landro, Francesco La Pietra, Sara Maria Pagotto, Laura Porta, Ilaria Staiano, Céline Giraudeau, Juan Verde, Khalid Ambarki, Leonardo Bianchi, Sanzhar Korganbayev, Henrik Odéen, Benoit Gallix, and Paola Saccomandi
Published: 2022
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2. Toward A User-Centred Design Approach for AR Technologies in Online Higher Education.

Author: Mitchell Peters, Laura Porta Simó, Antoni Marín Amatller, Laura Calvet Liñan, and Pierre Bourdin Kreitz
Published: 2021
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3. ValID: A Trust-Based Virtual Assessment System.

Author: Joan Arnedo-Moreno, David Bañeres, Xavier Baró, Santi Caballé, Ana-Elena Guerrero, Xavier Mas, Laura Porta, and Josep Prieto
Published: 2014
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4. Effects of Applying the Site Map Principle in an Online Learning Environment in Higher Education.

Author: Laura Porta Simó, Roser Beneito-Montagut, Javier Melenchón Maldonado, and Antoni Marín Amatller
Published: 2015
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5. Uso didáctico del vídeo en la web: potencialidades y requerimientos tecnológicos.

Author: Laura Porta Simó, Antoni Marín Amatller, and Carlos Casado Martínez
Published: 2007

6. Lesson in understanding parents’ perspective: perception of quality of care and COVID-19-related fears among users of paediatric health services over the COVID-19 pandemic in 11 facilities in Italy

Author: Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Alessandro Zago, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, and Sara Rivellini
Subjects: Pediatrics, RJ1-570
Abstract: Background The COVID-19 pandemic had an important psychological impact on children and their families. This study aims to explore paediatric health services users’ perceptions of quality of care (QOC) and COVID-19-related fears, and their evolution over time in relation to COVID-19 pandemic.Methods In a multicentre cross-sectional study involving 11 public hospitals providing paediatric care across the Italian territory, we collected data from services users through a validated questionnaire. We analysed four indicators—(1) QOC perceived in relation to COVID-19; (2) overall QOC perceived; (3) fear of accessing health services due to COVID-19; (4) fear of contracting COVID-19 in hospital—and calculated Spearman’s correlation indexes (ρ) with the number of COVID-19 new cases over time. Subgroup analyses were conducted by macroregions and single facility.Results Data from 956 services users were analysed. QOC indicators were stable over time at values close to the maximum (range 77–100 and median 100 for COVID-19 QOC, range 74–98 and median 80 for overall QOC), and no correlations were found with the COVID-19 new cases (ρ=−0.073 and −0.016, respectively). Fear of accessing care and fear of contracting the infection varied over time in between 0%–52% and 0%–53%, respectively, but did not correlate directly with number of COVID-19 new cases (ρ=0.101, 0.107 and 0.233, 0.046, respectively). At subgroup analyses, significantly higher frequencies of fear (p values
Published: 2024
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7. Titulaciones de multimedia en la UOC: dos décadas, cuatro planes de estudio y mucho futuro

Author: César Pablo Córcoles Briongos, Ferran Giménez, and Laura Porta
Abstract: El nuevo plan de estudios de grado de Técnicas de Interacción Digital y Multimedia es una buena ocasión para reflexionar sobre más de veinte años de historia de formación sobre multimedia en la UOC y la evolución de las diferentes encarnaciones del grado de Multimedia, desde el original graduado Multimedia a distancia UPC-UOC.
Published: 2021
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8. Toward A User-Centred Design Approach for AR Technologies in Online Higher Education

Author: Peters, Mitchell, primary, Simo, Laura Porta, additional, Amatller, Antoni Marin, additional, Linan, Laura Calvet, additional, and Kreitz, Pierre Bourdin, additional
Published: 2021
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9. Evaluation of the WHO standards to assess quality of care for children with acute respiratory infections: findings of a baseline multicentre assessment (CHOICE) in Italy

Author: Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, and Sara Rivellini
Subjects: Pediatrics, RJ1-570
Published: 2024
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10. Implementation of the WHO standards to assess the quality of care for children with acute diarrhoea: findings of a multicentre study (CHOICE) in Italy

Author: Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, Sara Rivellini, Sara Dal Bo, and Vita Antonella Di Stefano
Subjects: Pediatrics, RJ1-570
Published: 2024
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11. Implementation of the WHO Standards to assess quality of paediatric care at the facility level using service users’ perspective as source of data: a multicentre quality improvement study in Italy

Author: Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, Sara Rivellini, and Giuseppina De Rosa
Subjects: Pediatrics, RJ1-570
Published: 2024
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12. Implementation of the WHO standards to assess quality of care for children with acute pain in EDs: findings of a multicentre study (CHOICE) in Italy

Author: Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, and Sara Rivellini
Subjects: Pediatrics, RJ1-570
Published: 2024
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13. Implementation of the WHO Standards to assess the quality of paediatric care using health workers as source of data: findings of a multicentre study (CHOICE) in Italy

Author: Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, Sara Rivellini, Sara Dal Bo, Giuseppina De Rosa, Dal Bo Sara, Troisi Angela, Cozzi Giorgio, and Amaddeo Alessandro
Subjects: Pediatrics, RJ1-570
Published: 2024
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14. Gestión pedagógica y calidad educativa en docentes de la Institución Educativa República del Ecuador - Villa María del Triunfo – 2019

Author: Laura Porta, Aquilina Margarita and Cornejo Zuñiga, Alfonso Gedulfo
Subjects: Gestión Pedagógica, Calidad Educativa
Abstract: En la investigación titulada Gestión pedagógica y calidad educativa en docentes de la Institución Educativa República del Ecuador - Villa María del Triunfo – 2019, se formuló el problema ¿Cuál es la relación existe entre la gestión pedagógica y la calidad educativa en docentes de la Institución Educativa República del Ecuador- Villa María del Triunfo -2019?, con el objetivo de determinar la relación que existe entre la gestión pedagógica y la calidad educativa en docentes de la Institución Educativa República del Ecuador- Villa María del Triunfo -2019, siendo la hipótesis de que existe relación significativa entre la gestión pedagógica y la calidad educativa en docentes de la Institución Educativa República del Ecuador- Villa María del Triunfo -2019, V1: Gestión Pedagógica V2: Calidad Educativa, La investigación se realizará con un enfoque cuantitativo, de acuerdo al libro de Sánchez y Reyes (2006), titulado Metodología y diseños de la investigación científica, La Gestión pedagógica se relacionan directa y significativamente con la calidad educativa en docentes de la Institución Educativa República del Ecuador- Villa María del Triunfo – 2019, (p = 0.000 < 0.05, Rho de Spearman = 0.811 siendo correlación positiva alta). Por lo tanto, la Gestión pedagógica genera adecuada, significación de la tarea, favoreciendo de esta manera la calidad educativa en docentes de la Institución Educativa República del Ecuador- Villa María del Triunfo – 2019, Las instituciones educativas deben promover y dar a conocer la gestión pedagógica y la calidad educativa en docentes de la Institución Educativa República del Ecuador- Villa María del Triunfo – 2019 Universidad Nacional de Educación Enrique Guzmán y Valle Tesis
Published: 2019

15. Entrevista a Marc Segura, finalista de los premios EIMT

Author: Laura Porta
Abstract: Marc Segura ha sido finalista de los premios a los mejores trabajos de final de grado (TFG) y de máster (TFM) de los Estudios de Informática, Multimedia y Telecomunicación de la UOC (EIMT). En esta entrevista, nos cuenta cómo ha sido su experiencia como estudiante en la UOC, sus motivaciones para la realización del proyecto y sus sensaciones como finalista.
Published: 2019
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16. Entrevista con Núria Casaldàliga, periodista y estudiante del grado Multimedia

Author: Laura Porta
Abstract: Núria Casaldàliga es una periodista estudiante del grado Multimedia de la Universitat Oberta de Cataluya (UOC) que por iniciativa propia se propuso como candidata para realizar unas prácticas curriculares en una empresa especializada en diseño y programación. En este artículo, conoceremos el punto de vista de la estudiante sobre la importancia de realizar prácticas en el ámbito privado antes de finalizar los estudios.
Published: 2019
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17. Psicoterapia di coppia - Psicoterapia di gruppo Una dialettica possibile?

Author: Lidia Vitalini, V. Chiorino, Simonetta Verdecchia, A. Castebarco, Barbara Bianchini, Rina Maria Galeaz, and Laura Porta
Subjects: Group psychotherapy, Unconscious mind, Clinical work, Psychotherapist, Dynamics (music), Self, medicine.medical_treatment, medicine, Meaning (existential), Psychoanalytic theory, Psychology, Reciprocal
Abstract: Couple psychotherapy - Group psychotherapy. A possible dialogue? - Through the exploration of the "bond" concept (as expressed by Kaes) - which is the specific unconscious reality that emerges from the encounter of two or more subjects - work with couples is analyzed through the evolution of what the authors see as the most fruitful paradigms for clinical work. Our understanding of individual and group psychoanalytic psychotherapy is examined, and basic clinical theoretical tenets are identified during the meeting with the couple. We determine the cardinal concepts by which we explore the evergrowing complexity of emotional dynamics. The therapist needs to observe and investigate both inner and outer personal aspects, as well as reciprocal emotional dynamics in order to define not only the self but also the meaning of us. The authors examine different phases in the couple’s life, and, more specifically, what happens within the couple when a newborn arrives. Particular attention is given to the construction of the couple’s common setting. Referring to transference and counter-transference dynamics, analogies and differences between group psychotherapy and couple psychotherapy are outlined in order to establish a possible dialogue between the two approaches. Key words: bond, couple, group, transference, counter-transference, unconscious group organizers.
Published: 2009
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18. Effects of applying the site map principle in an online learning environment in higher education

Author: Javier Melenchn Maldonado, Laura Porta Sim, Antoni Marn-Amatller, Roser Beneito-Montagut, and Universitat Oberta de Catalunya (UOC)
Subjects: Higher education, Computer science, Process (engineering), Interface (Java), aprender en línea, online learning, Web sites -- Design, interfaz web, computer.software_genre, Web-based instruction, Enseñanza virtual, site map principle, Páginas web -- Diseño, Education, Human–computer interaction, principio del mapa del sitio, aprenentatge en línia, Pàgines web -- Disseny, Multimedia, graphic map, business.industry, General Engineering, Educational technology, educació superior, web interface, principi del mapa del lloc, interfície web, Ensenyament virtual, Synchronous learning, higher education, mapa grafico, mapa gràfic, educación más alta, User interface, business, computer, Site map, Cognitive load
Abstract: Web interfaces play a very important role in teaching-learning processes in virtual environments, since this is how students carry out their activity. This paper describes a web interface for online learning based on a graphic map that orients learners, tries to reduce cognitive overload, gives access to learning resources and personalizes learning. The interface was designed to guide the learning process in accordance with Shapiro’s “site map principle”. The objective of this article is to analyze the impact of such web interface on students' satisfaction with the learning process and on their academic performance. We conducted experimental research. The experiment tested the goodness of the interface among students enrolled in a Multimedia Degree in an open university. We used the T-Test, the Chi-square Test and the Kendall correlation Test. The results showed that the interface had a positive impact on students’ satisfaction and performance. It also encouraged students to take a more proactive role in their learning activity than with the “normal” interface. These results are in keeping with the features the site map principle has shown in face-to-face environments.
Published: 2015

19. Left-sided heart failure burden and mortality in idiopathic pulmonary fibrosis: a population-based study

Author: Ardita Koteci, Ann D. Morgan, Laura Portas, Hannah R. Whittaker, Constantinos Kallis, Peter M. George, and Jennifer K. Quint
Subjects: Idiopathic pulmonary fibrosis, Left-sided heart failure, Epidemiology, Diseases of the respiratory system, RC705-779
Abstract: Abstract Background Cardiovascular disease is prevalent in idiopathic pulmonary fibrosis (IPF), yet the extent of left-sided heart failure (HF) burden, whether this has changed with time and whether HF impacts mortality risk in these patients are unknown. The aims of this study were therefore to determine the temporal trends in incidence and prevalence of left-sided HF in patients with IPF in England and compare these to published estimates in the general population and those with comparable chronic respiratory conditions such as chronic obstructive pulmonary disease (COPD), as well as determine the risk of all-cause and cause-specific mortality in patients with comorbid left-sided HF and IPF at population-level using electronic healthcare data. Methods Clinical Practice Research Datalink (CPRD) Aurum primary-care data linked to mortality and secondary-care data was used to identify IPF patients in England. Left-sided HF prevalence and incidence rates were calculated for each calendar year between 2010 and 2019, stratified by age and sex. Risk of all-cause, cardiovascular and IPF-specific mortality was calculated using multivariate Cox regression. Results From 40,577patients with an IPF code in CPRD Aurum, 25, 341 IPF patients met inclusion criteria. Left-sided HF prevalence decreased from 33.4% (95% CI 32.2–34.6) in 2010 to 20.9% (20.0–21.7) in 2019. Left-sided HF incidence rate per 100 person-years (95% CI) remained stable between 2010 and 2017 but decreased from 4.3 (3.9–4.8) in 2017 to 3.4 (3.0–3.9) in 2019. Throughout follow-up, prevalence and incidence were higher in men and with increasing age. Comorbid HF was associated with poorer survival (adjusted HR (95%CI) 1.08 (1.03–1.14) for all-cause mortality; 1.32 (1.09–1.59) for cardiovascular mortality). Conclusion Left-sided HF burden in IPF patients in England remains high, with incidence almost 4 times higher than in COPD, a comparable lung disease with similar cardiovascular risk factors. Comorbid left-sided HF is also a poor prognostic marker. More substantial reduction in left-sided HF prevalence than incidence suggests persistently high IPF mortality. Given rising IPF incidence in the UK, this calls for better management of comorbidities such as left-sided HF to help optimise IPF survival.
Published: 2022
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20. A critical appraisal of neurological evidence on paediatric COVID-19 patients. A systematic literature review

Author: Raffaele Falsaperla, Chiara Gulisano, Laura Portale, Amanda Maccarrone, and Martino Ruggieri
Subjects: SARS-CoV-2, Children, Neurological complications, Clinical presentations, Diagnostics, Outcome, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Objective: The aim of our study was to assess the close direct relationship between the development of neurological manifestations and SARS-CoV-2 infection in paediatric patients, by a systematic review of the literature. Methods: PubMed and Google Scholar were searched for publications from the start of the pandemic up to 31 December 2022. We included articles that described nervous system manifestations in patients aged 0–18 years with RT-PCR nasopharyngeal swab positivity for SARS-CoV-2. Results: The initial search produced 3456 records, of which 37, involving a total of 48 paediatric patients, were included in our systematic review. The neurological complications were heterogeneous, due at least in part to the different age groups considered. In the literature, encephalitis was the most common diagnosis (20.83%). Clinical presentation, diagnostic support, treatment and outcome were analysed both in the literature and in our experience. Conclusions: Neurological impairment can occur with the first clinical presentation of COVID-19, even in previously healthy children and with mild forms of the disease. The clinical presentations are heterogeneous in the different age groups. In most patients the outcome is good and neurological manifestations subside after discharge.
Published: 2023
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21. EcomLab

Author: Anna Martorano, Laura Porta, and Carlos Casado Martínez
Abstract: En 2009 la fundación ECOM crea el portal ECOMLAB.cat, una herramienta interactiva con la voluntad de sensibilizar a los jóvenes sobre la discapacidad y que está pensada para ser usada tanto en casa como en la escuela. Este año, el portal ha sido el ganador del premio a la interactividad Gran Laus.
Published: 2010
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22. Tíscar Lara

Author: Laura Porta, César Córcoles, and Ferran Giménez
Abstract: Tíscar Lara es la Vicedecana de Cultura Digital en la Escuela de Organización industrial (EOI). En esta entrevista nos hablará sobre el proyecto Mobile Learning de esta escuela, un proyecto innovador dentro del campo de la educación que se está desarrollando en dicha escuela y que comprende los dispositivos móviles como facilitadores de la expansión del aula en entornos digitales.
Published: 2010
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23. Hacia una multimedia educativa

Author: Laura Porta
Abstract: La educación ha sido una de las grandes beneficiarias de la llegada del multimedia, pero es importante saber diseñar y utilizar el potencial didáctico de los recursos multimedia para la enseñanza-aprendizaje. En el artículo se abordan las dificultades en el diseño de elementos multimedia educativos y se plantea una propuesta de modelo de diseño de recursos didácticos multimedia.
Published: 2008
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24. Héctor Ruiz

Author: Laura Porta and Montserrat Ruiz
Abstract: Héctor Ruiz es el Director Editorial de la empresa responsable de los Digital-Text. Se trata de la primera apuesta firme de una editorial para el uso de las nuevas tecnologías en educación secundaria, en todo el estado: libros 100% curriculares creados para adecuarse i aprovechar el máximo las posibilidades que ofrece el soporte informático.
Published: 2008
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25. Gonzalo Trespaderne y Manuel Merlo

Author: Laura Porta and Roser Montserrat
Abstract: Gonzalo Trespaderne y Manuel Merlo son profesores de Filosofía y de Biología en el IES Abdera de Adra, Almería. Han ganado, en dos ocasiones, los premios que otorga el Ministerio de Educación para materiales curriculares en soporte electrónico. El multimedia ha llegado con fuerza al mundo de la educación y estos dos profesores nos cuentan su experiencia en la elaboración de aplicaciones informáticas para la docencia.
Published: 2008
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26. Pere Soldevila

Author: Carlos Albadalejo and Laura Porta
Abstract: Pere Soldevila, gerente de la galería de arte Metropolitana Barcelona y Oscar Abril Ascaso, co-comisario de exposiciones de Sonar y programador del Centro de Arte Santa Mónica de Barcelona nos explican su particular visión del arte digital y de su situación actual en España.
Published: 2006
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27. Oscar Abril Ascaso

Author: Laura Porta and Carlos Albadalejo
Abstract: Pere Soldevila, gerente de la galería de arte Metropolitana Barcelona y Oscar Abril Ascaso, co-comisario de exposiciones de Sonar y programador del Centro de Arte Santa Mónica de Barcelona nos explican su particular visión del arte digital y de su situación actual en España.
Published: 2006
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28. Cory Doctorow

Author: Laura Porta, César Córcoles, and Carlos Albadalejo
Abstract: Este número a uno de los asuntos más candentes del panorama mundial en lo referente a cuestiones digitales: la polémica de la propiedad intelectual. Para conseguirlo, hemos entrevistado a cuatro nombres que tienen mucho que decir en este mundo: Cory Doctorow, Fred Von Lohmann, Georg C.F. Greve y Raquel Xalabarder.
Published: 2005
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29. Cory Doctorow (English version)

Author: César Córcoles, Carlos Albadalejo, and Laura Porta
Subjects: media_common.quotation_subject, English version, Art, Classics, media_common
Abstract: Este número a uno de los asuntos más candentes del panorama mundial en lo referente a cuestiones digitales: la polémica de la propiedad intelectual. Para conseguirlo, hemos entrevistado a cuatro nombres que tienen mucho que decir en este mundo: Cory Doctorow, Fred Von Lohmann, Georg C.F. Greve y Raquel Xalabarder.
Published: 2005
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30. Raquel Xalabarder

Author: Laura Porta and Carlos Albadalejo
Abstract: Entrevista a Raquel Xalabarder.
Published: 2005
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31. Georg C.F. Greve

Author: Carlos Albadalejo and Laura Porta
Abstract: Este número a uno de los asuntos más candentes del panorama mundial en lo referente a cuestiones digitales: la polémica de la propiedad intelectual. Para conseguirlo, hemos entrevistado a cuatro nombres que tienen mucho que decir en este mundo: Cory Doctorow, Fred Von Lohmann, Georg C.F. Greve y Raquel Xalabarder.
Published: 2005
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32. Fred Von Lohmann

Author: Carlos Albadalejo and Laura Porta
Subjects: media_common.quotation_subject, Art, media_common
Abstract: Este número a uno de los asuntos más candentes del panorama mundial en lo referente a cuestiones digitales: la polémica de la propiedad intelectual. Para conseguirlo, hemos entrevistado a cuatro nombres que tienen mucho que decir en este mundo: Cory Doctorow, Fred Von Lohmann, Georg C.F. Greve y Raquel Xalabarder.
Published: 2005
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33. Variants associated with HHIP expression have sex-differential effects on lung function [version 2; peer review: 2 approved]

Author: Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, and Louise V. Wain
Subjects: Medicine, Science
Abstract: Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P
Published: 2021
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34. Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]

Author: Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, and Louise V. Wain
Subjects: Medicine, Science
Abstract: Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P
Published: 2020
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35. Exome genotyping and linkage analysis identifies two novel linked regions and replicates two others for myopia in Ashkenazi Jewish families

Author: Claire L. Simpson, Anthony M. Musolf, Qing Li, Laura Portas, Federico Murgia, Roberto Y. Cordero, Jennifer B. Cordero, Bilal A. Moiz, Emily R. Holzinger, Candace D. Middlebrooks, Deyana D. Lewis, Joan E. Bailey-Wilson, and Dwight Stambolian
Subjects: Myopia, Genetic linkage, Family studies, Internal medicine, RC31-1245, Genetics, QH426-470
Abstract: Abstract Background Myopia is one of most common eye diseases in the world and affects 1 in 4 Americans. It is a complex disease caused by both environmental and genetics effects; the genetics effects are still not well understood. In this study, we performed genetic linkage analyses on Ashkenazi Jewish families with a strong familial history of myopia to elucidate any potential causal genes. Methods Sixty-four extended Ashkenazi Jewish families were previously collected from New Jersey. Genotypes from the Illumina ExomePlus array were merged with prior microsatellite linkage data from these families. Additional custom markers were added for candidate regions reported in literature for myopia or refractive error. Myopia was defined as mean spherical equivalent (MSE) of -1D or worse and parametric two-point linkage analyses (using TwoPointLods) and multi-point linkage analyses (using SimWalk2) were performed as well as collapsed haplotype pattern (CHP) analysis in SEQLinkage and association analyses performed with FBAT and rv-TDT. Results Strongest evidence of linkage was on 1p36(two-point LOD = 4.47) a region previously linked to refractive error (MYP14) but not myopia. Another genome-wide significant locus was found on 8q24.22 with a maximum two-point LOD score of 3.75. CHP analysis also detected the signal on 1p36, localized to the LINC00339 gene with a maximum HLOD of 3.47, as well as genome-wide significant signals on 7q36.1 and 11p15, which overlaps with the MYP7 locus. Conclusions We identified 2 novel linkage peaks for myopia on chromosomes 7 and 8 in these Ashkenazi Jewish families and replicated 2 more loci on chromosomes 1 and 11, one previously reported in refractive error but not myopia in these families and the other locus previously reported in the literature. Strong candidate genes have been identified within these linkage peaks in our families. Targeted sequencing in these regions will be necessary to definitively identify causal variants under these linkage peaks.
Published: 2019
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36. Seroepidemiology of Measles, Mumps, Rubella and Varicella in Italian Female School Workers: A Cross-Sectional Study

Author: Nicola Frau, Federico Meloni, Jacopo Fostinelli, Laura Portas, Igor Portoghese, Emma Sala, Ilaria Pilia, Luigi Isaia Lecca, Giuseppe De Palma, and Marcello Campagna
Subjects: early childhood teacher, school teacher, protective immunity, vaccine-preventable disease, public health surveillance, seroprevalence, Medicine
Abstract: Background: Determining the proportion of susceptible workers can represent a first step to the biological risk assessment related to measles, mumps, rubella and varicella exposure. This study aimed to assess the immunity against measles, mumps, rubella and varicella viruses in a cohort of female school workers. Methods: A cross-sectional seroepidemiological study in a sample of 263 school workers undergoing routine annual workplace health surveillance program was conducted. As part of the health surveillance program, serum samples were collected and tested for measles, mumps, rubella and varicella IgG antibodies. Results: Overall seropositivity was 90.5%, 85.2%, 94.7% and 97.3% for measles, mumps, rubella and varicella, respectively. In relation to mumps occupation-specific seropositivity, a statistically significant difference was observed, showing the lowest prevalence of protected individuals in other occupation groups. Moreover, in relation to rubella, school workers born in Centre Italy had the lowest seropositivity of protective antibodies and the difference between groups was statistically significant. Measles and rubella seropositivity showed a significant decrease after 2015. Conclusions: This study showed a relevant proportion of school workers susceptible to the aforementioned diseases. These results highlighted the need for proper health surveillance and immunological controls in school workers, especially for females, and provided useful insights to policymakers to select effective strategies aimed at containing the risk of vaccine-preventable diseases at schools.
Published: 2021
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37. Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

Author: Qiao Fan, Virginie J. M. Verhoeven, Robert Wojciechowski, Veluchamy A. Barathi, Pirro G. Hysi, Jeremy A. Guggenheim, René Höhn, Veronique Vitart, Anthony P. Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimäki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini, Masahiro Miyake, Alex W. Hewitt, Xiaobo Guo, Johanna Mazur, Jenifer E. Huffman, Katie M. Williams, Ozren Polasek, Harry Campbell, Igor Rudan, Zoran Vatavuk, James F. Wilson, Peter K. Joshi, George McMahon, Beate St Pourcain, David M. Evans, Claire L. Simpson, Tae-Hwi Schwantes-An, Robert P. Igo, Alireza Mirshahi, Audrey Cougnard-Gregoire, Céline Bellenguez, Maria Blettner, Olli Raitakari, Mika Kähönen, Ilkka Seppälä, Tanja Zeller, Thomas Meitinger, Janina S. Ried, Christian Gieger, Laura Portas, Elisabeth M. van Leeuwen, Najaf Amin, André G. Uitterlinden, Fernando Rivadeneira, Albert Hofman, Johannes R. Vingerling, Ya Xing Wang, Xu Wang, Eileen Tai-Hui Boh, M. Kamran Ikram, Charumathi Sabanayagam, Preeti Gupta, Vincent Tan, Lei Zhou, Candice E. H. Ho, Wan’e Lim, Roger W. Beuerman, Rosalynn Siantar, E-Shyong Tai, Eranga Vithana, Evelin Mihailov, Chiea-Chuen Khor, Caroline Hayward, Robert N. Luben, Paul J. Foster, Barbara E. K. Klein, Ronald Klein, Hoi-Suen Wong, Paul Mitchell, Andres Metspalu, Tin Aung, Terri L. Young, Mingguang He, Olavi Pärssinen, Cornelia M. van Duijn, Jie Jin Wang, Cathy Williams, Jost B. Jonas, Yik-Ying Teo, David A. Mackey, Konrad Oexle, Nagahisa Yoshimura, Andrew D. Paterson, Norbert Pfeiffer, Tien-Yin Wong, Paul N. Baird, Dwight Stambolian, Joan E. Bailey Wilson, Ching-Yu Cheng, Christopher J. Hammond, Caroline C. W. Klaver, Seang-Mei Saw, and Consortium for Refractive Error and Myopia (CREAM)
Subjects: Science
Abstract: This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.
Published: 2016
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38. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Author: Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y. Chu, Man Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin, Rossella Sorice, Yong Li, Daniel Taliun, Matthias Olden, Meredith Foster, Qiong Yang, Ming-Huei Chen, Tune H. Pers, Andrew D. Johnson, Yi-An Ko, Christian Fuchsberger, Bamidele Tayo, Michael Nalls, Mary F. Feitosa, Aaron Isaacs, Abbas Dehghan, Pio d’Adamo, Adebowale Adeyemo, Aida Karina Dieffenbach, Alan B. Zonderman, Ilja M. Nolte, Peter J. van der Most, Alan F. Wright, Alan R. Shuldiner, Alanna C. Morrison, Albert Hofman, Albert V. Smith, Albert W. Dreisbach, Andre Franke, Andre G. Uitterlinden, Andres Metspalu, Anke Tonjes, Antonio Lupo, Antonietta Robino, Åsa Johansson, Ayse Demirkan, Barbara Kollerits, Barry I. Freedman, Belen Ponte, Ben A. Oostra, Bernhard Paulweber, Bernhard K. Krämer, Braxton D. Mitchell, Brendan M. Buckley, Carmen A. Peralta, Caroline Hayward, Catherine Helmer, Charles N. Rotimi, Christian M. Shaffer, Christian Müller, Cinzia Sala, Cornelia M. van Duijn, Aude Saint-Pierre, Daniel Ackermann, Daniel Shriner, Daniela Ruggiero, Daniela Toniolo, Yingchang Lu, Daniele Cusi, Darina Czamara, David Ellinghaus, David S. Siscovick, Douglas Ruderfer, Christian Gieger, Harald Grallert, Elena Rochtchina, Elizabeth J. Atkinson, Elizabeth G. Holliday, Eric Boerwinkle, Erika Salvi, Erwin P. Bottinger, Federico Murgia, Fernando Rivadeneira, Florian Ernst, Florian Kronenberg, Frank B. Hu, Gerjan J. Navis, Gary C. Curhan, George B. Ehret, Georg Homuth, Stefan Coassin, Gian-Andri Thun, Giorgio Pistis, Giovanni Gambaro, Giovanni Malerba, Grant W. Montgomery, Gudny Eiriksdottir, Gunnar Jacobs, Guo Li, H-Erich Wichmann, Harry Campbell, Helena Schmidt, Henri Wallaschofski, Henry Völzke, Hermann Brenner, Heyo K. Kroemer, Holly Kramer, Honghuang Lin, I. Mateo Leach, Ian Ford, Idris Guessous, Igor Rudan, Inga Prokopenko, Ingrid Borecki, Iris M. Heid, Ivana Kolcic, Ivana Persico, J. Wouter Jukema, James F. Wilson, Janine F. Felix, Jasmin Divers, Jean-Charles Lambert, Jeanette M. Stafford, Jean-Michel Gaspoz, Jennifer A. Smith, Jessica D. Faul, Jie Jin Wang, Jingzhong Ding, Joel N. Hirschhorn, John Attia, John B. Whitfield, John Chalmers, Jorma Viikari, Josef Coresh, Joshua C. Denny, Juha Karjalainen, Jyotika K. Fernandes, Karlhans Endlich, Katja Butterbach, Keith L. Keene, Kurt Lohman, Laura Portas, Lenore J. Launer, Leo-Pekka Lyytikäinen, Loic Yengo, Lude Franke, Luigi Ferrucci, Lynda M. Rose, Lyudmyla Kedenko, Madhumathi Rao, Maksim Struchalin, Marcus E. Kleber, Margherita Cavalieri, Margot Haun, Marilyn C. Cornelis, Marina Ciullo, Mario Pirastu, Mariza de Andrade, Mark A. McEvoy, Mark Woodward, Martin Adam, Massimiliano Cocca, Matthias Nauck, Medea Imboden, Melanie Waldenberger, Menno Pruijm, Marie Metzger, Michael Stumvoll, Michele K. Evans, Michele M. Sale, Mika Kähönen, Mladen Boban, Murielle Bochud, Myriam Rheinberger, Niek Verweij, Nabila Bouatia-Naji, Nicholas G. Martin, Nick Hastie, Nicole Probst-Hensch, Nicole Soranzo, Olivier Devuyst, Olli Raitakari, Omri Gottesman, Oscar H. Franco, Ozren Polasek, Paolo Gasparini, Patricia B. Munroe, Paul M. Ridker, Paul Mitchell, Paul Muntner, Christa Meisinger, Johannes H. Smit, ICBP Consortium, AGEN Consortium, CARDIOGRAM, CHARGe-Heart Failure Group, ECHOGen Consortium, Peter Kovacs, Philipp S. Wild, Philippe Froguel, Rainer Rettig, Reedik Mägi, Reiner Biffar, Reinhold Schmidt, Rita P. S. Middelberg, Robert J. Carroll, Brenda W. Penninx, Rodney J. Scott, Ronit Katz, Sanaz Sedaghat, Sarah H. Wild, Sharon L. R. Kardia, Sheila Ulivi, Shih-Jen Hwang, Stefan Enroth, Stefan Kloiber, Stella Trompet, Benedicte Stengel, Stephen J. Hancock, Stephen T. Turner, Sylvia E. Rosas, Sylvia Stracke, Tamara B. Harris, Tanja Zeller, Tatijana Zemunik, Terho Lehtimäki, Thomas Illig, Thor Aspelund, Tiit Nikopensius, Tonu Esko, Toshiko Tanaka, Ulf Gyllensten, Uwe Völker, Valur Emilsson, Veronique Vitart, Ville Aalto, Vilmundur Gudnason, Vincent Chouraki, Wei-Min Chen, Wilmar Igl, Winfried März, Wolfgang Koenig, Wolfgang Lieb, Ruth J. F. Loos, Yongmei Liu, Harold Snieder, Peter P. Pramstaller, Afshin Parsa, Jeffrey R. O’Connell, Katalin Susztak, Pavel Hamet, Johanne Tremblay, Ian H. de Boer, Carsten A. Böger, Wolfram Goessling, Daniel I. Chasman, Anna Köttgen, W. H. Linda Kao, and Caroline S. Fox
Subjects: Science
Abstract: Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.
Published: 2016
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39. Study of animal remains dug out during the excavations of a Nuragic village in Sardinia

Author: Laura Portas, Stefania Bagella, Vittorio Farina, Marcella Carcupino, Antonio Cacchioli, Ferdinando Gazza, and Marco Zedda
Subjects: Animal remains, Archaeological excavations, Nuragic settlement, Sardinia, Biology (General), QH301-705.5
Abstract: This paper presents the results of the zooarchaeological analysis of the faunal materials brought to light during the excavations set up in the Nuragic village surrounding the Santu Antine Nuraghe, near Torralba (Sassari), Sardinia. Precisely, the remains come from the structure of the village named by archaeologists hut 12. They are 779 specimens out of thousands animal remains from the whole archaeological site. The majority of the rests belong to sheep (Ovis aries) or goats (Capra hircus), cattle (Bos taurus), pigs (Sus scrofa) and deers (Cervus elaphus). Such material may provide suggestions about the productive use of animals in the village and point out the importance of the economical management of animals in the Nuragic society. Indeed, many remains show signs with human origin, which testify that the hut may have been a workplace where bone fragments were processed to obtain different kind of tools.
Published: 2015
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40. Anatomical study of animal remains from Phoenician-Punic amphorae found in the Santa Giusta Pond, Sardinia (Italy)

Author: Laura Portas, Vittorio Farina, Carla Del Vais, Marcella Carcupino, Ferdinando Gazza, Ignazio Sanna, and Marco Zedda
Subjects: Phoenician-Punic amphorae, Sheep, Goat, Cattle, Zooarchaeology, Biology (General), QH301-705.5
Abstract: During the underwater excavations carried out in the Santa Giusta Pond, near Oristano, Sardinia, a significant amount of Phoenician- Punic materials was brought to light including amphorae (dating back to 7th-2nd century BC) and vegetal and animal remains. All of these archaeological finds may come from Othoca, an important Phoenician- Punic city on the eastern shore of the pond, geographically corresponding with the modern-day town of Santa Giusta. Animal materials consist of more than 3000 very well-preserved remains, belonging to sheep (Ovis aries), goat (Capra hircus) and cattle (Bos taurus). Bone analyses allowed reconstructing the slaughtering methods, as well as manipulation procedures carried out to preserve meat in order to be exported overseas. Although pig (Sus scrofa) played an important economical role in other Sardinian Phoenician-Punic settlements, in this archaeological context this species is absent, suggesting that the meat contained in the amphorae was probably destined to other areas of the Mediterranean basin, where people did not eat pork.
Published: 2015
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41. Modulation of genetic associations with serum urate levels by body-mass-index in humans.

Author: Jennifer E Huffman, Eva Albrecht, Alexander Teumer, Massimo Mangino, Karen Kapur, Toby Johnson, Zoltán Kutalik, Nicola Pirastu, Giorgio Pistis, Lorna M Lopez, Toomas Haller, Perttu Salo, Anuj Goel, Man Li, Toshiko Tanaka, Abbas Dehghan, Daniela Ruggiero, Giovanni Malerba, Albert V Smith, Ilja M Nolte, Laura Portas, Amanda Phipps-Green, Lora Boteva, Pau Navarro, Asa Johansson, Andrew A Hicks, Ozren Polasek, Tõnu Esko, John F Peden, Sarah E Harris, Federico Murgia, Sarah H Wild, Albert Tenesa, Adrienne Tin, Evelin Mihailov, Anne Grotevendt, Gauti K Gislason, Josef Coresh, Pio D'Adamo, Sheila Ulivi, Peter Vollenweider, Gerard Waeber, Susan Campbell, Ivana Kolcic, Krista Fisher, Margus Viigimaa, Jeffrey E Metter, Corrado Masciullo, Elisabetta Trabetti, Cristina Bombieri, Rossella Sorice, Angela Döring, Eva Reischl, Konstantin Strauch, Albert Hofman, Andre G Uitterlinden, Melanie Waldenberger, H-Erich Wichmann, Gail Davies, Alan J Gow, Nicola Dalbeth, Lisa Stamp, Johannes H Smit, Mirna Kirin, Ramaiah Nagaraja, Matthias Nauck, Claudia Schurmann, Kathrin Budde, Susan M Farrington, Evropi Theodoratou, Antti Jula, Veikko Salomaa, Cinzia Sala, Christian Hengstenberg, Michel Burnier, Reedik Mägi, Norman Klopp, Stefan Kloiber, Sabine Schipf, Samuli Ripatti, Stefano Cabras, Nicole Soranzo, Georg Homuth, Teresa Nutile, Patricia B Munroe, Nicholas Hastie, Harry Campbell, Igor Rudan, Claudia Cabrera, Chris Haley, Oscar H Franco, Tony R Merriman, Vilmundur Gudnason, Mario Pirastu, Brenda W Penninx, Harold Snieder, Andres Metspalu, Marina Ciullo, Peter P Pramstaller, Cornelia M van Duijn, Luigi Ferrucci, Giovanni Gambaro, Ian J Deary, Malcolm G Dunlop, James F Wilson, Paolo Gasparini, Ulf Gyllensten, Tim D Spector, Alan F Wright, Caroline Hayward, Hugh Watkins, Markus Perola, Murielle Bochud, W H Linda Kao, Mark Caulfield, Daniela Toniolo, Henry Völzke, Christian Gieger, Anna Köttgen, and Veronique Vitart
Subjects: Medicine, Science
Abstract: We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10-8), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10-8), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10-4). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
Published: 2015
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42. Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.

Author: Claire L Simpson, Robert Wojciechowski, Konrad Oexle, Federico Murgia, Laura Portas, Xiaohui Li, Virginie J M Verhoeven, Veronique Vitart, Maria Schache, S Mohsen Hosseini, Pirro G Hysi, Leslie J Raffel, Mary Frances Cotch, Emily Chew, Barbara E K Klein, Ronald Klein, Tien Yin Wong, Cornelia M van Duijn, Paul Mitchell, Seang Mei Saw, Maurizio Fossarello, Jie Jin Wang, DCCT/EDIC Research Group, Ozren Polašek, Harry Campbell, Igor Rudan, Ben A Oostra, André G Uitterlinden, Albert Hofman, Fernando Rivadeneira, Najaf Amin, Lennart C Karssen, Johannes R Vingerling, Angela Döring, Thomas Bettecken, Goran Bencic, Christian Gieger, H-Erich Wichmann, James F Wilson, Cristina Venturini, Brian Fleck, Phillippa M Cumberland, Jugnoo S Rahi, Chris J Hammond, Caroline Hayward, Alan F Wright, Andrew D Paterson, Paul N Baird, Caroline C W Klaver, Jerome I Rotter, Mario Pirastu, Thomas Meitinger, Joan E Bailey-Wilson, and Dwight Stambolian
Subjects: Medicine, Science
Abstract: Refractive error (RE) is a complex, multifactorial disorder characterized by a mismatch between the optical power of the eye and its axial length that causes object images to be focused off the retina. The two major subtypes of RE are myopia (nearsightedness) and hyperopia (farsightedness), which represent opposite ends of the distribution of the quantitative measure of spherical refraction. We performed a fixed effects meta-analysis of genome-wide association results of myopia and hyperopia from 9 studies of European-derived populations: AREDS, KORA, FES, OGP-Talana, MESA, RSI, RSII, RSIII and ERF. One genome-wide significant region was observed for myopia, corresponding to a previously identified myopia locus on 8q12 (p = 1.25×10(-8)), which has been reported by Kiefer et al. as significantly associated with myopia age at onset and Verhoeven et al. as significantly associated to mean spherical-equivalent (MSE) refractive error. We observed two genome-wide significant associations with hyperopia. These regions overlapped with loci on 15q14 (minimum p value = 9.11×10(-11)) and 8q12 (minimum p value 1.82×10(-11)) previously reported for MSE and myopia age at onset. We also used an intermarker linkage- disequilibrium-based method for calculating the effective number of tests in targeted regional replication analyses. We analyzed myopia (which represents the closest phenotype in our data to the one used by Kiefer et al.) and showed replication of 10 additional loci associated with myopia previously reported by Kiefer et al. This is the first replication of these loci using myopia as the trait under analysis. "Replication-level" association was also seen between hyperopia and 12 of Kiefer et al.'s published loci. For the loci that show evidence of association to both myopia and hyperopia, the estimated effect of the risk alleles were in opposite directions for the two traits. This suggests that these loci are important contributors to variation of refractive error across the distribution.
Published: 2014
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43. Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

Author: Conall M O'Seaghdha, Hongsheng Wu, Qiong Yang, Karen Kapur, Idris Guessous, Annie Mercier Zuber, Anna Köttgen, Candice Stoudmann, Alexander Teumer, Zoltán Kutalik, Massimo Mangino, Abbas Dehghan, Weihua Zhang, Gudny Eiriksdottir, Guo Li, Toshiko Tanaka, Laura Portas, Lorna M Lopez, Caroline Hayward, Kurt Lohman, Koichi Matsuda, Sandosh Padmanabhan, Dmitri Firsov, Rossella Sorice, Sheila Ulivi, A Catharina Brockhaus, Marcus E Kleber, Anubha Mahajan, Florian D Ernst, Vilmundur Gudnason, Lenore J Launer, Aurelien Mace, Eric Boerwinckle, Dan E Arking, Chizu Tanikawa, Yusuke Nakamura, Morris J Brown, Jean-Michel Gaspoz, Jean-Marc Theler, David S Siscovick, Bruce M Psaty, Sven Bergmann, Peter Vollenweider, Veronique Vitart, Alan F Wright, Tatijana Zemunik, Mladen Boban, Ivana Kolcic, Pau Navarro, Edward M Brown, Karol Estrada, Jingzhong Ding, Tamara B Harris, Stefania Bandinelli, Dena Hernandez, Andrew B Singleton, Giorgia Girotto, Daniela Ruggiero, Adamo Pio d'Adamo, Antonietta Robino, Thomas Meitinger, Christa Meisinger, Gail Davies, John M Starr, John C Chambers, Bernhard O Boehm, Bernhard R Winkelmann, Jie Huang, Federico Murgia, Sarah H Wild, Harry Campbell, Andrew P Morris, Oscar H Franco, Albert Hofman, Andre G Uitterlinden, Fernando Rivadeneira, Uwe Völker, Anke Hannemann, Reiner Biffar, Wolfgang Hoffmann, So-Youn Shin, Pierre Lescuyer, Hughes Henry, Claudia Schurmann, SUNLIGHT Consortium, GEFOS Consortium, Patricia B Munroe, Paolo Gasparini, Nicola Pirastu, Marina Ciullo, Christian Gieger, Winfried März, Lars Lind, Tim D Spector, Albert V Smith, Igor Rudan, James F Wilson, Ozren Polasek, Ian J Deary, Mario Pirastu, Luigi Ferrucci, Yongmei Liu, Bryan Kestenbaum, Jaspal S Kooner, Jacqueline C M Witteman, Matthias Nauck, W H Linda Kao, Henri Wallaschofski, Olivier Bonny, Caroline S Fox, and Murielle Bochud
Subjects: Genetics, QH426-470
Abstract: Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in ≤ 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
Published: 2013
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44. Genome-wide association and functional follow-up reveals new loci for kidney function.

Author: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A Böger, Christian Fuchsberger, Matthias Olden, Ming-Huei Chen, Adrienne Tin, Daniel Taliun, Man Li, Xiaoyi Gao, Mathias Gorski, Qiong Yang, Claudia Hundertmark, Meredith C Foster, Conall M O'Seaghdha, Nicole Glazer, Aaron Isaacs, Ching-Ti Liu, Albert V Smith, Jeffrey R O'Connell, Maksim Struchalin, Toshiko Tanaka, Guo Li, Andrew D Johnson, Hinco J Gierman, Mary Feitosa, Shih-Jen Hwang, Elizabeth J Atkinson, Kurt Lohman, Marilyn C Cornelis, Åsa Johansson, Anke Tönjes, Abbas Dehghan, Vincent Chouraki, Elizabeth G Holliday, Rossella Sorice, Zoltan Kutalik, Terho Lehtimäki, Tõnu Esko, Harshal Deshmukh, Sheila Ulivi, Audrey Y Chu, Federico Murgia, Stella Trompet, Medea Imboden, Barbara Kollerits, Giorgio Pistis, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Tamara B Harris, Lenore J Launer, Thor Aspelund, Gudny Eiriksdottir, Braxton D Mitchell, Eric Boerwinkle, Helena Schmidt, Margherita Cavalieri, Madhumathi Rao, Frank B Hu, Ayse Demirkan, Ben A Oostra, Mariza de Andrade, Stephen T Turner, Jingzhong Ding, Jeanette S Andrews, Barry I Freedman, Wolfgang Koenig, Thomas Illig, Angela Döring, H-Erich Wichmann, Ivana Kolcic, Tatijana Zemunik, Mladen Boban, Cosetta Minelli, Heather E Wheeler, Wilmar Igl, Ghazal Zaboli, Sarah H Wild, Alan F Wright, Harry Campbell, David Ellinghaus, Ute Nöthlings, Gunnar Jacobs, Reiner Biffar, Karlhans Endlich, Florian Ernst, Georg Homuth, Heyo K Kroemer, Matthias Nauck, Sylvia Stracke, Uwe Völker, Henry Völzke, Peter Kovacs, Michael Stumvoll, Reedik Mägi, Albert Hofman, Andre G Uitterlinden, Fernando Rivadeneira, Yurii S Aulchenko, Ozren Polasek, Nick Hastie, Veronique Vitart, Catherine Helmer, Jie Jin Wang, Daniela Ruggiero, Sven Bergmann, Mika Kähönen, Jorma Viikari, Tiit Nikopensius, Michael Province, Shamika Ketkar, Helen Colhoun, Alex Doney, Antonietta Robino, Franco Giulianini, Bernhard K Krämer, Laura Portas, Ian Ford, Brendan M Buckley, Martin Adam, Gian-Andri Thun, Bernhard Paulweber, Margot Haun, Cinzia Sala, Marie Metzger, Paul Mitchell, Marina Ciullo, Stuart K Kim, Peter Vollenweider, Olli Raitakari, Andres Metspalu, Colin Palmer, Paolo Gasparini, Mario Pirastu, J Wouter Jukema, Nicole M Probst-Hensch, Florian Kronenberg, Daniela Toniolo, Vilmundur Gudnason, Alan R Shuldiner, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, David S Siscovick, Cornelia M van Duijn, Ingrid Borecki, Sharon L R Kardia, Yongmei Liu, Gary C Curhan, Igor Rudan, Ulf Gyllensten, James F Wilson, Andre Franke, Peter P Pramstaller, Rainer Rettig, Inga Prokopenko, Jacqueline C M Witteman, Caroline Hayward, Paul Ridker, Afshin Parsa, Murielle Bochud, Iris M Heid, Wolfram Goessling, Daniel I Chasman, W H Linda Kao, and Caroline S Fox
Subjects: Genetics, QH426-470
Abstract: Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
Published: 2012
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45. Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits

Author: Ginevra Biino, Carlo L. Balduini, Laura Casula, Piergiorgio Cavallo, Simona Vaccargiu, Debora Parracciani, Donatella Serra, Laura Portas, Federico Murgia, and Mario Pirastu
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Background Thrombocytopenia is a common finding in several diseases but almost nothing is known about the prevalence of thrombocytopenia in the general population. We examined the prevalence of thrombocytopenia and determinants of platelet count in a healthy population with a wide age range.Design and Methods We performed a cross-sectional study on 12,517 inhabitants of ten villages (80% of residents) in a secluded area of Sardinia (Ogliastra). Participants underwent a complete blood count evaluation and a structured questionnaire, used to collect epidemiological data.Results We observed a platelet count lower than 150×109/L in 3.2% (2.8%–3.6%) of females and 4.8% (4.3%–5.4%) of males, with a value of 3.9% (3.6%–4.3%) in the entire population. Thrombocytopenia was mild (platelet count: 100×109/L–150×109/L), asymptomatic and not associated with other cytopenias or overt disorders in most cases. Its standardized prevalence was quite different in different villages, with values ranging from 1.5% to 6.8%, and was negatively correlated with the prevalence of a mild form of thrombocytosis, which ranged from 0.9% to 4.5%. Analysis of platelet counts across classes of age revealed that platelet number decreased progressively with aging. As a consequence, thrombocytopenia was nearly absent in young people and its prevalence increased regularly during lifetime. The opposite occurred for thrombocytosis.Conclusions Given the high genetic differentiation among Ogliastra villages with “high” and “low” platelet counts and the substantial heritability of this quantitative trait (54%), we concluded that the propensity to present mild and transient thrombocytosis in youth and to acquire mild thrombocytopenia during aging are new genetic traits.
Published: 2011
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46. Migració d'aplicacions actuarials a Azure: Anàlisi i model de gestió

Author: Prats Armengol, Alexandra, Sergio Schvarstein Liuboschetz, and Laura Porta Simó
Subjects: migració, núvol, gestió de projectes, migración, nube, gestión de proyectos, migration, cloud, project management
Abstract: La migració al núvol és un repte al que moltes empreses s'estan enfrontant actualment i que requereix d'una detallada anàlisi prèvia per tal de que es realitzi de forma eficient i acabi resultant realment avantatjós. El present treball parteix d'un cas d'estudi centrat en un conjunt d'aplicacions del sector assegurador i desenvolupa la fase inicial del projecte de migració a la plataforma Azure, establint l'estratègia a seguir, els components a usar i aplicant el model de gestió seleccionat a la planificació inicial. Per tal d'arribar a aquest objectiu final es realitza prèviament una anàlisi de la plataforma Azure que permet entendre-la en profunditat i seleccionar els components a utilitzar i, per un altra banda, s'analitzen les diferents metodologies de gestió de projectes IT fins arribar a un model de gestió híbrid que és el que s'aplicarà al projecte de migració. Més enllà del cas concret treballat, l'anàlisi desenvolupada pot servir de base per plantejar tant la migració a Azure com l'elecció d'un model de gestió a aplicar, depenent de les característiques de cada projecte. La migración a la nube es un reto al que muchas empresas se están enfrentando actualmente y que requiere de un detallado análisis previo para que se realice de forma eficiente y acabe resultando realmente ventajoso. El presente trabajo parte de un caso de estudio centrado en un conjunto de aplicaciones del sector asegurador y desarrolla la fase inicial del proyecto de migración a la plataforma Azure, estableciendo la estrategia a seguir, los componentes a utilizar y aplicando el modelo de gestión seleccionado en la planificación inicial. Para llegar a este objetivo final se realiza previamente un análisis de la plataforma Azure que permite entenderla en profundidad y seleccionar los componentes a utilizar y, por otro lado, se analizan las diferentes metodologías de gestión de proyectos IT hasta llegar a un modelo de gestión híbrido que es el que se aplicará en el proyecto de migración. Más allá del caso concreto trabajado, el análisis desarrollado puede servir de base para plantear tanto la migración a Azure como la elección de un modelo de gestión a aplicar, dependiendo de las características de cada proyecto. Migration to the cloud is a challenge that many companies are currently facing, and it requires detailed prior analysis to do it efficiently and in a truly cost-effective manner. This paper is based on a case study focused on a suite of applications in the insurance sector and develops the initial phase of the migration project to the Azure platform, establishing the strategy to be followed, the components to be used, and applying the selected management model to the initial plan. In order to reach this final goal, an analysis of the Azure platform is carried out beforehand, which allows to understand it in depth and to select the components to be used. On the other hand, the different IT project management methodologies are analyzed until reach a hybrid management model, which will be applied to the migration project. Beyond the specific case worked on, the analysis developed can serve as a basis for considering both the migration to Azure and the choice of a management model to apply, depending on the characteristics of each project.
Published: 2022

47. iOLEO, Diseño de interfaz interactiva para aplicación web e-commerce de libros de segunda mano

Author: Hermoso Gómez, María Eugenia, Laura Porta Simó, and Mikel Zorrilla Berasategui
Subjects: Segunda mano, Libros, E-commerce, App, Aplicación web
Abstract: El objetivo del presente trabajo es realizar el concepto, diseño y prototipo de la interfaz de una aplicación web de tipo e-commerce para la compra y venta de libros de segunda mano, que permitiría también dar a conocer y comercializar publicaciones autoeditadas. Al ser una aplicación web, es multidispositivo, y se podrá utilizar desde pc, tablets y dispositivos móviles. El proyecto se enmarca dentro de la tipología de desarrollo de interfaz. Se escoge el mercado de libros de segunda mano por su auge social derivado de la necesidad de ahorro, la concienciación medioambiental y las tendencias sociales. Se emplea una metodología de trabajo ágil basada en el método Kanban y se trabaja con recursos bibliográficos y software de prototipo, concretamente Adobe XD, así como software de diseño y maquetación, Adobe Illustrator y Adobe InDesign para elaborar los documentos anexos al proyecto, tales como vídeos, manuales, etc. El producto resultante es un prototipo interactivo de nueva creación basado en la estructura de un e-commerce. Se presenta en versiones pc y móvil. The objective of this project is to design the concept, the art, and the prototype of an e- commerce web app for shopping and selling second-hand books, and self-published works. Because it's a web app, it is multi-device, and it can be used from pc, tablet or smartphone. This Master Thesis project is framed into the type of interface development. I've chosen the books second-hand market because of the social boom caused by the need of saving money, the environmental awareness and trends. For the development it's been used the agile methodology, based in Kanban method. Also it's been used prototype software, specifically Adobe XD, and design and editorial design software, Adobe Illustrator and Adobe InDesing for making the videos, user's manual, etc. The resultant product is a hi-fi prototype that is new-created based in the structure of an e-commerce. It's showed to use for pc and smarthphes. L'objectiu d'aquest projecte és dissenyar el concepte, l'art i el prototip d'una aplicació web de comerç electrònic per comprar i vendre llibres de segona mà i obres d'autoedició. Com que és una aplicació web, és multidispositiu i es pot utilitzar des de l'ordinador, la tauleta o el telèfon intel·ligent.
Published: 2021

48. Prototipo de una aplicación web para apoyar a través de las TIC los procesos de enseñanza y aprendizaje: Ecosistema Tecno-Pedagógico

Author: Morales Rodriguez, Adriana, Universitat Oberta de Catalunya, Sergio Schvarstein Liuboschetz, and Laura Porta Simó
Subjects: Tecnologías de la Información y la Comunicación (TIC), Pedagogía, Aplicación web
Abstract: El proyecto consiste en el diseño de un prototipo interactivo de alta definición para una aplicación web, que tiene el propósito de facilitar la selección, uso y evaluación reflexiva de recursos TIC (Tecnologías de la Información y la Comunicación) que apoyen los procesos de enseñanza y aprendizaje, en la Pontificia Universidad Javeriana de Cali - Colombia. Dicha aplicación se denomina: Ecosistema Tecno-pedagógico. Para el desarrollo del prototipo de la aplicación web se implementó la metodología del diseño centrado en el usuario. El diferencial de esta propuesta es que su diseño está fundamentado en un estudio de usuarios y responde específicamente a las necesidades de la Institución, la cual tiene un modelo particular, fundamentado en una filosofía educativa y una experiencia en el ámbito de educación y tecnología. La aplicación web está dirigida a tres perfiles de usuario: Profesor, Asesor pedagógico y Asesor en la producción audiovisual. Estos perfiles cuentan con acceso a información sobre sus principales temas de interés: Formación en competencias TIC, herramientas TIC y su uso pedagógico, recursos educativos digitales, propuestas pedagógicas y acceso a una comunidad de aprendizaje en torno al uso de las TIC en la educación.
Published: 2018

49. Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci

Author: Paul, Ds, Albers, Ca, Rendon, A, Voss, K, Stephens, J, Akkerman, Jan Willem N., Albers, Cornelis A., Ale, Algra, Abtehale Al Hussani, Hooman, Allayee, Franco, Anni, Asselbergs, Folkert W., Antony, Attwood, Beverley, Balkau, Stefania, Bandinelli, François, Bastardot, Saonli, Basu, Baumeister, Sebastian E., Jacques, Beckmann, Beben, Benyamin, Ginevra, Biino, Bis, Joshua C., Lorenzo, Bomba, Amélie, Bonnefond, Boomsma, Dorret I., Bradley, John R., François, Cambien, Chambers, John C., Marina, Ciullo, Cookson, William O., Francesco, Cucca, Ana, Cvejic, D'Adamo, ADAMO PIO, John, Danesh, Fabrice, Danjou, Debashish, Das, Gail, Davies, Paul IW de Bakker, de Boer, Rudolf A., Eco JC de Geus, Deary, Ian J., Dedoussis, George V., Panos, Deloukas, Maria, Dimitriou, Christian, Dina, Angela, Döring, Ulrich, Elling, David, Ellinghaus, Paul, Elliott, Gunnar, Engström, Jeanette, Erdmann, Tõnu, Esko, Evans, David M., Eyjolfsson, Gudmundur I., Mario, Falchi, Wei, Feng, Ferreira, Manuel A., Luigi, Ferrucci, Krista, Fischer, Folsom, Aaron R., Paolo, Fortina, Andre, Franke, Lude, Franke, Frazer, Ian H., Philippe, Froguel, Renzo, Galanello, Ganesh, Santhi K., Garner, Stephen F., Gasparini, Paolo, Bernd, Genser, Gibson, Quince D., Christian, Gieger, Girotto, Giorgia, Glazer, Nicole L., Martin, Gögele, Goodall, Alison H., Andreas, Greinacher, Gudbjartsson, Daniel F., Chris, Hammond, Harris, Sarah E., Jaana, Hartiala, Anna Liisa Hartikainen, Hazen, Stanley L., Heckbert, Susan R., Hedblad, Bo, Christian, Hengstenberg, Micha, Hersch, Hicks, Andrew A., Hilma, Holm, Jouke Jan Hottenga, Thomas, Illig, Marjo Riitta Jarvelin, Jennifer, Jolley, Steve, Jupe, Mika, Kähönen, Naoyuki, Kamatani, Stavroula, Kanoni, Kema, Ido P., Kemp, John P., Jyoti, Khadake, Kay Tee Khaw, Kleber, Marcus E., Kooner, Jaspal S., Peter, Kovacs, Brigitte, Kühnel, Marie Christine Kyrtsonis, Yann, Labrune, Vasiliki, Lagou, Claudia, Langenberg, Terho, Lehtimäki, Xinzhong, Li, Liming, Liang, Lifelines Cohort Study, Heather Lloyd Jones, Ruth JF Loos, Lopez, Lorna M., Thomas, Lumley, Leo Pekka Lyytikäinen, Winfried, Maerz, Reedik, Mägi, Massimo, Mangino, Martin, Nicholas G., Andrea, Maschio, Irene Mateo Leach, Barbara, Mcknight, Stuart, Meacham, Medland, Sarah E., Christa, Meisinger, Olle, Melander, Yasin, Memari, Andres, Metspalu, Kathy, Miller, Mitchell, Braxton D., Moffatt, Miriam F., Montgomery, Grant W., Carmel, Moore, Federico, Murgia, Yusuke, Nakamura, Matthias, Nauck, Gerjan, Navis, Nolte, Ilja M., Ute, Nöthlings, Teresa, Nutile, Yukinori, Okada, Isleifur, Olafsson, Onundarson, Pall T., O’Reilly, Paul F., Ouwehand, Willem H., Debora, Parracciani, Afshin, Parsa, Paul, Dirk S., Penninger, Josef M., Penninx, Brenda W., Mario, Pirastu, Pirastu, Nicola, Giorgio, Pistis, Eleonora, Porcu, Laura, Portas, David, Porteous, Anneli, Pouta, Pramstaller, Peter P., Inga, Prokopenko, Psaty, Bruce M., Janne, Pullat, Aparna, Radhakrishnan, Olli, Raitakari, Ramiro Ramirez Solis, Augusto, Rendon, Ried, Janina S., Ring, Susan M., Robino, Antonietta, Rotter, Jerome I., Daniela, Ruggiero, Aimo, Ruokonen, Cinzia, Sala, Andres, Saluments, Samani, Nilesh J., Jennifer, Sambrook, Serena, Sanna, David, Schlessinger, Schmidt, Carsten O., Stefan, Schreiber, Heribert, Schunkert, James, Scott, Joban, Sehmi, Jovana Serbanovic Canic, So Youn Shin, Shuldiner, Alan R., Rob, Sladek, Smit, Johannes H., George Davey Smith, Gustav Smith, J., Smith, Nicholas L., Harold, Snieder, Nicole, Soranzo, Rossella, Sorice, Spector, Timothy D., Starr, John M., Kari, Stefansson, Derek, Stemple, Jonathan, Stephens, Michael, Stumvoll, Patrick, Sulem, Atsushi, Takahashi, Sian Tsung Tan, Toshiko, Tanaka, Clara, Tang, Weihong, Tang, WH Wilson Tang, Kent, Taylor, Albert, Tenesa, Alexander, Teumer, Swee Lay Thein, Unnur, Thorsteinsdottir, Daniela, Toniolo, Anke, Tönjes, Traglia, Michela, Manuela, Uda, Sheila, Ulivi, Pim van der Harst, Ellen van der Schoot, C., van Gilst, Wiek H., Joost van Pelt, L., van Veldhuisen, Dirk J., Niek, Verweij, Visscher, Peter M., Uwe, Völker, Peter, Vollenweider, Katrin, Voss, Wareham, Nicholas J., Lorenz, Wernisch, Harm Jan Westra, Whitfield, John B., Herich, Wichmann, Wiggins, Kerri L., Gonneke, Willemsen, Winkelmann, Bernhard R., Gerald, Wirnsberger, Bruce HR Wolffenbuttel, Jian, Yang, Tsun Po Yang, Weihua, Zhang, Jing Hua Zhao, Paavo, Zitting, Jaap Jan Zwaginga, van der Harst, P, Chambers, Jc, Soranzo, N, Ouwehand, Wh, Deloukas, P., Paul, D, Albers, Ca, Rendon, A, Voss, K, Stephens, J, Jan Willem N., Akkerman, Cornelis A., Alber, Ale, Algra, Abtehale Al, Hussani, Hooman, Allayee, Franco, Anni, Folkert W., Asselberg, Antony, Attwood, Beverley, Balkau, Stefania, Bandinelli, François, Bastardot, Saonli, Basu, Sebastian E., Baumeister, Jacques, Beckmann, Beben, Benyamin, Ginevra, Biino, Joshua C., Bi, Lorenzo, Bomba, Amélie, Bonnefond, Dorret I., Boomsma, John R., Bradley, François, Cambien, John C., Chamber, Marina, Ciullo, William O., Cookson, Francesco, Cucca, Ana, Cvejic, D'Adamo, ADAMO PIO, John, Danesh, Fabrice, Danjou, Debashish, Da, Gail, Davie, Paul IW de, Bakker, Rudolf A., de Boer, Eco JC de, Geu, Ian J., Deary, George V., Dedoussi, Panos, Delouka, Maria, Dimitriou, Christian, Dina, Angela, Döring, Ulrich, Elling, David, Ellinghau, Paul, Elliott, Gunnar, Engström, Jeanette, Erdmann, Tõnu, Esko, David M., Evan, Gudmundur I., Eyjolfsson, Mario, Falchi, Wei, Feng, Manuel A., Ferreira, Luigi, Ferrucci, Krista, Fischer, Aaron R., Folsom, Paolo, Fortina, Andre, Franke, Lude, Franke, Ian H., Frazer, Philippe, Froguel, Renzo, Galanello, Santhi K., Ganesh, Stephen F., Garner, Gasparini, Paolo, Bernd, Genser, Quince D., Gibson, Christian, Gieger, Girotto, Giorgia, Nicole L., Glazer, Martin, Gögele, Alison H., Goodall, Andreas, Greinacher, Daniel F., Gudbjartsson, Chris, Hammond, Sarah E., Harri, Jaana, Hartiala, Anna Liisa, Hartikainen, Stanley L., Hazen, Susan R., Heckbert, Bo, Hedblad, Christian, Hengstenberg, Micha, Hersch, Andrew A., Hick, Hilma, Holm, Jouke Jan, Hottenga, Thomas, Illig, Marjo Riitta, Jarvelin, Jennifer, Jolley, Steve, Jupe, Mika, Kähönen, Naoyuki, Kamatani, Stavroula, Kanoni, Ido P., Kema, John P., Kemp, Jyoti, Khadake, Kay Tee, Khaw, Marcus E., Kleber, Jaspal S., Kooner, Peter, Kovac, Brigitte, Kühnel, Marie Christine, Kyrtsoni, Yann, Labrune, Vasiliki, Lagou, Claudia, Langenberg, Terho, Lehtimäki, Xinzhong, Li, Liming, Liang, Lifelines Cohort, Study, Heather Lloyd, Jone, Ruth JF, Loo, Lorna M., Lopez, Thomas, Lumley, Leo Pekka, Lyytikäinen, Winfried, Maerz, Reedik, Mägi, Massimo, Mangino, Nicholas G., Martin, Andrea, Maschio, Irene Mateo, Leach, Barbara, Mcknight, Stuart, Meacham, Sarah E., Medland, Christa, Meisinger, Olle, Melander, Yasin, Memari, Andres, Metspalu, Kathy, Miller, Braxton D., Mitchell, Miriam F., Moffatt, Grant W., Montgomery, Carmel, Moore, Federico, Murgia, Yusuke, Nakamura, Matthias, Nauck, Gerjan, Navi, Ilja M., Nolte, Ute, Nöthling, Teresa, Nutile, Yukinori, Okada, Isleifur, Olafsson, Pall T., Onundarson, Paul F., O’Reilly, Willem H., Ouwehand, Debora, Parracciani, Afshin, Parsa, Dirk S., Paul, Josef M., Penninger, Brenda W., Penninx, Mario, Pirastu, Pirastu, Nicola, Giorgio, Pisti, Eleonora, Porcu, Laura, Porta, David, Porteou, Anneli, Pouta, Peter P., Pramstaller, Inga, Prokopenko, Bruce M., Psaty, Janne, Pullat, Aparna, Radhakrishnan, Olli, Raitakari, Ramiro Ramirez, Soli, Augusto, Rendon, Janina S., Ried, Susan M., Ring, Robino, Antonietta, Jerome I., Rotter, Daniela, Ruggiero, Aimo, Ruokonen, Cinzia, Sala, Andres, Salument, Nilesh J., Samani, Jennifer, Sambrook, Serena, Sanna, David, Schlessinger, Carsten O., Schmidt, Stefan, Schreiber, Heribert, Schunkert, James, Scott, Joban, Sehmi, Jovana Serbanovic, Canic, So Youn, Shin, Alan R., Shuldiner, Rob, Sladek, Johannes H., Smit, George Davey, Smith, J., Gustav Smith, Nicholas L., Smith, Harold, Snieder, Nicole, Soranzo, Rossella, Sorice, Timothy D., Spector, John M., Starr, Kari, Stefansson, Derek, Stemple, Jonathan, Stephen, Michael, Stumvoll, Patrick, Sulem, Atsushi, Takahashi, Sian Tsung, Tan, Toshiko, Tanaka, Clara, Tang, Weihong, Tang, WH Wilson, Tang, Kent, Taylor, Albert, Tenesa, Alexander, Teumer, Swee Lay, Thein, Unnur, Thorsteinsdottir, Daniela, Toniolo, Anke, Tönje, Traglia, Michela, Manuela, Uda, Sheila, Ulivi, Pim van der, Harst, C., Ellen van der Schoot, Wiek H., van Gilst, L., Joost van Pelt, Dirk J., van Veldhuisen, Niek, Verweij, Peter M., Visscher, Uwe, Völker, Peter, Vollenweider, Katrin, Vo, Nicholas J., Wareham, Lorenz, Wernisch, Harm Jan, Westra, John B., Whitfield, Herich, Wichmann, Kerri L., Wiggin, Gonneke, Willemsen, Bernhard R., Winkelmann, Gerald, Wirnsberger, Bruce HR, Wolffenbuttel, Jian, Yang, Tsun Po, Yang, Weihua, Zhang, Jing Hua, Zhao, Paavo, Zitting, Jaap Jan, Zwaginga, van der Harst, P, Chambers, Jc, Soranzo, N, Ouwehand, Wh, Deloukas, P., Biological Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, EMGO+ - Mental Health, Neuroscience Campus Amsterdam - Brain Imaging Technology, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England, UCL, UCL Canc Inst, London WC1E 6BT, England, Univ Cambridge, Dept Haematol, Cambridge CB2 0PT, England, Natl Hlth Serv NHS Blood & Transplant, Cambridge CB2 0PT, England, Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands, Inst Publ Hlth, MRC Biostat Unit, Cambridge CB2 0SR, England, NIHR Biomed Res Ctr, Cambridge CB2 0PT, England, Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 GZ Groningen, Netherlands, Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 GZ Groningen, Netherlands, Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London W2 1NY, England, Hammersmith Hosp, Imperial Coll Healthcare NHS Trust, London W12 0HS, England, Royal Brompton & Harefield Hosp NHS Trust, London SW3 6NP, England, Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England, Psychiatry, Epidemiology and Data Science, NCA - Brain mechanisms in health and disease, NCA - Neurobiology of mental health, EMGO - Mental health, NCA - Brain imaging technology, and Cardiovascular Centre (CVC)
Subjects: Netherlands Twin Register (NTR), Erythrocytes, Genome-wide association study, UNCERTAINTY, Regulatory Sequences, Nucleic Acid, VARIANTS, ANNOTATION, COLORECTAL-CANCER, Histones, 0302 clinical medicine, BINDING, Cluster Analysis, Myeloid Cells, Genetics (clinical), Genetics, hematological trait, 0303 health sciences, Chromosome Mapping, MRP4 ABCC4, Chromatin, Nucleosomes, Phenotype, Organ Specificity, 030220 oncology & carcinogenesis, Blood Platelets, Quantitative Trait Loci, Biology, Quantitative trait locus, Polymorphism, Single Nucleotide, DYNAMIN 3, 03 medical and health sciences, Quantitative Trait, Heritable, MEGAKARYOCYTES, Humans, Cell Lineage, ddc:610, GENOME-WIDE ASSOCIATION, Enhancer, Transcription factor, Gene, ChIA-PET, 030304 developmental biology, Research, Genetic Variation, DNA, Chromatin Assembly and Disassembly, Genetic architecture, Gene Expression Regulation, Genome-Wide Association Study
Abstract: To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. Nearly three-quarters of the 143 genetic signals associated with platelet and erythrocyte phenotypes identified by meta-analyses of genome-wide association (GWA) studies are located at non-protein-coding regions. Here, we assessed the role of candidate regulatory variants associated with cell type-restricted, closely related hematological quantitative traits in biologically relevant hematopoietic cell types. We used formaldehyde-assisted isolation of regulatory elements followed by next-generation sequencing (FAIRE-seq) to map regions of open chromatin in three primary human blood cells of the myeloid lineage. In the precursors of platelets and erythrocytes, as well as in monocytes, we found that open chromatin signatures reflect the corresponding hematopoietic lineages of the studied cell types and associate with the cell type-specific gene expression patterns. Dependent on their signal strength, open chromatin regions showed correlation with promoter and enhancer histone marks, distance to the transcription start site, and ontology classes of nearby genes. Cell type-restricted regions of open chromatin were enriched in sequence variants associated with hematological indices. The majority (63.6%) of such candidate functional variants at platelet quantitative trait loci (QTLs) coincided with binding sites of five transcription factors key in regulating megakaryopoiesis. We experimentally tested 13 candidate regulatory variants at 10 platelet QTLs and found that 10 (76.9%) affected protein binding, suggesting that this is a frequent mechanism by which regulatory variants influence quantitative trait levels. Our findings demonstrate that combining large-scale GWA data with open chromatin profiles of relevant cell types can be a powerful means of dissecting the genetic architecture of closely related quantitative traits. Marie-Curie Initial Training Network NETSIM British Heart Foundation RG/09/12/28096 National Institutes for Health RP-PG-0310-1002 Wellcome Trust 098051 info:eu-repo/grantAgreement/EC/FP7/282510
Published: 2013
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