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1. Physical inactivity and protein energy wasting play independent roles in muscle weakness in maintenance haemodialysis patients.

Author

Jean-Sébastien Souweine, Nils Kuster, Leila Chenine, Annie Rodriguez, Laure Patrier, Marion Morena, Eric Badia, Lotfi Chalabi, Nathalie Raynal, Isabelle Ohresser, Helene Leray-Moragues, Jacques Mercier, Maurice Hayot, Moglie Le Quintrec, Fares Gouzi, and Jean-Paul Cristol

Subjects
Medicine, Science
Abstract

BACKGROUND:Muscle weakness is associated with increased mortality risk in chronic haemodialysis (CHD) patients. Protein energy wasting (PEW) and low physical activity could impair muscle quality and contribute to muscle weakness beyond muscle wasting in these patients. Aim of this study was to assess clinical and biological parameters involved in the reduction of muscle strength of CHD patients. METHODS:One hundred and twenty-three CHD patients (80 males, 43 females; 68,8 [57.9-78.8] y.o.) were included in this study. Maximal voluntary force (MVF) of quadriceps was assessed using a belt-stabilized hand-held dynamometer. Muscle quality was evaluated by muscle specific torque, defined as the strength per unit of muscle mass. Muscle mass was estimated using lean tissue index (LTI), skeletal muscle mass (SMM) assessed by bioelectrical impedance analysis and creatinine index (CI). Voorrips questionnaire was used to estimate physical activity. Criteria for the diagnosis of PEW were serum albumin, body mass index < 23 kg/m2, creatinine index < 18.82 mg/kg/d and low dietary protein intake estimated by nPCR < 0.80g/kg/d. RESULTS:MVF was 76.1 [58.2-111.7] N.m. and was associated with CI (β = 5.3 [2.2-8.4], p = 0.001), LTI (β = 2.8 [0.6-5.1], p = 0.013), Voorrips score (β = 17.4 [2.9-31.9], p = 0.02) and serum albumin (β = 1.9 [0.5-3.2], p = 0.006). Only serum albumin (β = 0.09 [0.03-0.15], p = 0.003), Voorrips score (β = 0.8 [0.2-1.5], p = 0.005) and CI (β = 0.2 [0.1-0.3], p

Published
2018
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2. HDL proteome in hemodialysis patients: a quantitative nanoflow liquid chromatography-tandem mass spectrometry approach.

Author

Alain Mangé, Aurélie Goux, Stéphanie Badiou, Laure Patrier, Bernard Canaud, Thierry Maudelonde, Jean-Paul Cristol, and Jérôme Solassol

Subjects
Medicine, Science
Abstract

Aside from a decrease in the high-density lipoprotein (HDL) cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV) risk in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis (HD). Dysfunctional HDL leads to an alteration of reverse cholesterol transport and the antioxidant and anti-inflammatory properties of HDL. In this study, a quantitative proteomics approach, based on iTRAQ labeling and nanoflow liquid chromatography mass spectrometry analysis, was used to generate detailed data on HDL-associated proteins. The HDL composition was compared between seven chronic HD patients and a pool of seven healthy controls. To confirm the proteomics results, specific biochemical assays were then performed in triplicate in the 14 samples as well as 46 sex-matched independent chronic HD patients and healthy volunteers. Of the 122 proteins identified in the HDL fraction, 40 were differentially expressed between the healthy volunteers and the HD patients. These proteins are involved in many HDL functions, including lipid metabolism, the acute inflammatory response, complement activation, the regulation of lipoprotein oxidation, and metal cation homeostasis. Among the identified proteins, apolipoprotein C-II and apolipoprotein C-III were significantly increased in the HDL fraction of HD patients whereas serotransferrin was decreased. In this study, we identified new markers of potential relevance to the pathways linked to HDL dysfunction in HD. Proteomic analysis of the HDL fraction provides an efficient method to identify new and uncharacterized candidate biomarkers of CV risk in HD patients.

Published
2012
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3. Cardioprotective Effect of Acute Intradialytic Exercise

Author

Matthieu Josse, Laure Patrier, Myriam Isnard, Cécile Turc-Baron, Antoine Grandperrin, Stéphane Nottin, Stéphane Mandigout, Jean-Paul Cristol, Claire Maufrais, and Philippe Obert

Subjects
Nephrology, General Medicine
Published
2023

5. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Cécile Couchoud, Florian Bayer, Carole Ayav, Clémence Béchade, Philippe Brunet, François Chantrel, Luc Frimat, Roula Galland, Maryvonne Hourmant, Emmanuelle Laurain, Thierry Lobbedez, Lucile Mercadal, Olivier Moranne, Abdelhamid Abbassi, Alain Debure, Abdallah Guerraoui, Abdelatif Benmoussa, Abdelaziz Hamani, Abdelaziz Ziane, Abdelhamid Nefti, Abdelkader Hadj, Abderrahim El Amari, Abderrahmane Ghazali, Abo Bakr Abd El Fatah Mohamed, Achour Laradi, Adel Ben Ahmed, Adel Sahar, Adele Pillet, Adeline Lacraz, Adnan Moinat, Afshin Massoumi, Agathe Pardon, Agnes Caillette Beaudoin, Agnes Chapelet Debout, Agnes Mariot, Ahmed Rachi, Aida Afiani, Aime Remy Boula, Al Jalaby, Alain Cremault, Alain Fournier, Alain Jeanson, Alain Lyon, Alain Nony, Alain Robert, Alain Slingeneyer, Alanor Agnes Labatide, Albane Brodin Sartorius, Albert Bensman, Albert Fournier, Alex Ranlin, Alex Vido Sandor, Alexandra Colombo, Alexandra Duhem, Alexandra Stancu, Alexandre Dufay, Alexandre Dumoulin, Alexandre Ebel, Alexandre Klein, Alexandre Martin, Alexandre Mouneimne, Alexandre Seidowsky, Alfio De Martin, Alfredo Zannier, Ali Aizel, Ali Hafi, Ali Zineddine Diddaoui, Alim Heyani, Alina Mocanu, Alina Preda, Aline Hafi, Aline Talaszka, Alyette Duquesne, Amar Amaouche, Amel Ghemmour, Amelie Simon, Amina Skalli, Amine Boukadida, Amr Ekhlas Ragab Eid, Ana Fedorca, Anabelle Baillet, Anais Poyet, Ancuta Bouffandeau Giorgita, Anderson Ratsimbazafy, Andre Pruna, Angel Argiles, Angelo Testa, Ann Karolien Vandooren, Anne Jolivot, Anne Kolko Labadens, Anne Lataste, Anne Maisin, Anne Paris, Anne Sechet, Anne Wuillai, Anne Elisabeth Heng, Anne Gaelle Josse, Anne Helene Querard, Anne Helene Reboux, Anne Laure Adra, Anne Laure Faller, Anne Laure Leclerc, Anne Laure Poitou, Annie Lahoche Manucci, Antoine Jacquet, Antoine Pommereau, Antoine Thierry, Arezki Adem, Arielle Chapelet, Arnaud Del Bello, Arnaud Delezire, Arnaud Garnier, Arnaud Guerard, Arnaud Klisnick, Arnaud Lionet, Arnaud Roccabianca, Arnaud Stolz, Arthur Capdeville, Asma Allal, Assem Alrifai, Assetou Diarrassouba, Assia Djema, Assia Ferhat Carre, Astrid Godron Dubrasquet, Atman Haddj Elmrabet, Audrey Jegado, Aurelia Bertholet Thomas, Aurelie Davourie Salandre, Aurelie Pajot, Aurelien Lorthioir, Aurelien Tiple, Aurore Sury, Ayman Abokasem, Ayman Sarraj, Bachir Henaoui, Baher Chaghouri, Bassem Wehbe, Beatrice Ball, Beatrice Viron, Belkassem Issad, Benedicte Hodemon Corne, Benedicte Janbon, Benjamin Deroure, Benjamin Savenkoff, Benoit Jonon, Benoit Vendrely, Benyakoub Djelaleddine, Bernard Ohry, Bernard Painchart, Bernard Strullu, Bernard Temperville, Bertin Ebikili, Bertrand Hacq, Bertrand Morel, Bilal Aoun, Blanca Muniz, Bouchra Chlih, Brahim Amara, Brice Mayor, Brigitte Gilson, Brigitte Llanas, Brigitte Zins, Bruno Bourgeon, Bruno Coevoet, Bruno Guery, Bruno Legallicier, Bruno Paris, Bruno Ranchin, Bruno Seigneuric, Camelia Ghiciuc Dita, Camelia Prelipcean, Carine Achard Hottelart, Carine Diet, Carlos Frangie, Carlos Vela, Carmina Muresan, Carole Deprele, Caroline Araujo, Caroline Bidault, Caroline Creput, Caroline Delclaux, Caroline Du Halgouet, Caroline Favennec, Caroline Freguin, Caroline Gourraud Vercel, Caroline Mesguen, Caroline Ndomo Obama, Caroline Poitou, Caroline Preissig Dirhold, Caroline Roubiou, Catherine Albert, Catherine Bessin, Catherine De Marion Gaja, Catherine Godart, Catherine Lasseur, Catherine Leocardi, Catherine Lumbroso, Catherine Melander, Catherine Michel, Catherine Quere Maurouard, Catherine Rouannet, Catherine Taddei, Cathy Verove, Cecile Guiraud, Cecile Tafelin, Cecile Turc Baron, Cedric Formet, Cedric Pinier, Celia Lessore De Ste Foy, Celine Granolleras, Chaouki Bennini, Charles Cartou, Charles Chazot, Charlotte Jouzel, Cherif Badid, Christa Roubicek, Christel Viaud, Christelle Verrier, Christian Chuet, Christian Combe, Christian Dabot, Christian Duvic, Christian Emond, Christian Lagarde, Christian Lamotte, Christian Pain, Christiane Mousson, Christie Lorriaux, Christine Beauchamp, Christine Fumeron, Christine Le Gurun, Christine Leroy, Christine Pietrement, Christine Richer, Christophe Bouaka, Christophe Charasse, Christophe Goupy, Christophe Ridel, Cindy Castrale, Cindy Detourne, Clair Francois, Claire Presne, Claire Trivin, Clarissa Von Kotze, Claude Bernard, Claude Bonniol, Claude Desvergnes, Claude Raharivelina, Claudia Nistor, Claudine Gueret, Claudine Lloret, Claudine Saltiel, Clelia Rosati, Clementine Rabate, Corina Stanescu, Corinne Ferrandini, Corinne Guibergia, Corinne Lemoine, Corinne Passeron, Cynthia Kahil, Cyril Garrouste, Cyril Vo Van, Cyrille Jolimoy, Dalila Kesraoui, Damien Jolly, Damien Thibaudin, Dan Teboulle, Daniel Daubresse, Daniel Louvet, Daniel Rasamimanantsoa, Daniel Toledano, Daniela Babici, Daniela David, Daniela Dincu, Danielle Bruno, Delia May, Delphine Haussaire, Delphine Henriet Viprey, Denis Bugnon, Denis Fouque, Denis Morin, Derradji Nour, Diab Mohamed Mahmoud, Diana Istrati Cristescu, Didier Aguilera, Didier Coste, Didier Hamel, Didier Le Chapois, Didier Testou, Dilaver Erbilgin, Djamal Dahmane, Doan Bui Quang, Dominique Bertrand, Dominique Besnier, Dominique Blanchier, Dominique Briffa, Dominique Caux, Dominique Durand, Dominique Fleury, Dominique Guerrot, Dominique Hestin, Dominique Jaubert, Dominique Joly, Dominique Lombart, Dominique Pagniez, Dominique Pierre, Dominique Schohn, Donatien Ikonga, Dorina Visanica, Dorothee Bazin, Edouard Boury, Edouard Maksour, Ekoue Agbonon, Elarbi Harrami, Elena Marcu, Elena Tudorache, Elisabeth Caniot, Elisabeth Semjen, Elisabeth Tomkiewicz, Elise Scheidt, Elke Gaboriau, Elodie Lamouroux, Elsa Guiard, Elsa Martin Passos, Emerson Nsembani, Emilie Fache, Emilie Kalbacher, Emilie Pambrun, Emilie Pincon, Emma Allain Launay, Emmanuel Baron, Emmanuel Dupuis, Emmanuel Villar, Emmanuelle Charlin, Emmanuelle Hecquet, Emmanuelle Kohler, Emmanuelle Rosier, Enrique Figueroa, Eric Azoulay, Eric Canivet, Eric Daugas, Eric Gauthier, Eric Laruelle, Eric Le Guen, Eric Legrand, Eric Moumas, Eric Postec, Eric Prinz, Eric Renaudineau, Estelle Desport, Estelle Ricard Sutra, Etienne Berard, Etienne Ged, Etienne Robin, Eve Vilaine, Evelyne Bargas, Evelyne Mac Namara, François Combarnous, Fatima Yazbeck, Fabien Gerard, Fabien Metivier, Fabien Parazols, Fabien Soulis, Fabrice Garnier, Fadhila Pech Messaoudene, Fadi Haidar, Fanny Boullenger, Fanny Lepeytre, Fanny Leroy, Fares Frejate, Farid Bellahsene, Farid Bellhasene, Farid Saidani, Fatouma Toure, Faycal Kriaa, Fazia Nemmar, Fernando Vetromile, Florence Chalmin, Florence Lucats, Florence Sens, Florence Villemain, Florent Plasse, Fouad Lebhour, Francis Schillinger, Franck Berge, Franck Bourdon, Franck Bridoux, Franck Reynaud, Francois Babinet, Francois Basse, Francois Chantrel, Francois Clair, Francois Coulomb, Francois De Cornelissen, Francois Glowacki, Francois Marchal, Francois Maurice, Francois Nobili, Francois Pourreau, Francois Provot, Francois Roux Amani, Francoise Broux, Francoise Bulte, Francoise Heibel, Francoise Leonetti, Francoise Moussion Schott, Frank Le Roy, Frederic Besson, Frederic Lavainne, Frederic Tollis, Frederique Bocquentin, Frederique Meeus, Frederique Vecina, Friederike Von Ey, Gabriel Balit, Gabriel Choukroun, Gabriel Gruget, Gabriel Huchard, Gabriella Golea, Gabrielle Duneau, Gaelle Lefrancois, Gaelle Pelle, Gaetan Lebrun, Genevieve Dumont, Georges Brillet, Georges Deschenes, Georges Mourad, Georges Stamatakis, Geraldine Cazajous, Geraldine D'ythurbide, Geraldine Robitaille Wiart, Gerard Cardon, Gerard Champion, Gerard Deschodt, Gerard Mangenot, Gerard Motte, Gerard Schortgen, Ghada Boulahia, Ghassan Maakaroun, Ghylene Bourdat Michel, Gilbert Zanetta, Gilles Hufnagel, Gilles Messier, Giorgina Piccoli, Gregoire Couvrat Desvergnes, Guillaume Bobrie, Guillaume Bonnard, Guillaume Clement, Guillaume Jean, Guillaume Queffeulou, Guillaume Seret, Guillaume Vernin, Guy Delavaud, Guy Lambrey, Guy Rostoker, Gwenaelle Poussard, Gwenaelle Roussey Kesler, H. Leon, Habib Aboubekr, Hacene Boulechfar, Hacene Sekhri, Hadia Hebibi, Hadjira Benalia, Hafed Fessi, Hafsabhai Atchia, Haiat Bittar, Hakim Maiza, Hakim Mazouz, Hamid El Ali, Hammouche Bougrida, Hans Van Der Pijl, Hassan Lokmane, Hassane Izzedine, Hassen Adda, Helene De Preneuf, Helene Leray, Helene Philippot, Henri Boulanger, Henri Merault, Henri Renaud, Herve Bonarek, Herve Maheut, Hilaire Nzeyimana, Hocine Mehama, Hocine Zaidi, Hugo Weclawiak, Hugues Flodrops, Huseyin Karaaslan, Ibrahim Haskour, Ihssen Belhadj, Imad Almoubarak, Imad Haddad, Ines Castellano, Ines Ferrandiz, Ioana Daniliuc, Ioana Darie, Ioana Enache, Ionut Prunescu, Irenee Djiconkpode, Irina Shahapuni, Isabelle Bouchoule, Isabelle Devriendt, Isabelle Kazes, Isabelle Kolb, Isabelle Landru, Isabelle Poli, Isabelle Rey, Isabelle Segalen, Isabelle Selcer, Isabelle Vernier, Isabelle Vrillon, Ismahane Guenifi, J. Dominique Gheerbrandt, Jacky Potier, Jacques Becart, Jacques Cledes, Jacques Ducros, Jacques Duvic, Jacques Fourcade, Jacques Gaultier, Jacques Jurine, Jacques Lebleu, Jacques Ollier, Jacques Ibsen Charles, Jamal Yazji, Janette Mansour, Jean Arnautou, Jean Brocard, Jean Carolfi, Jean Montoriol, Jean Baptiste Gouin, Jean Bernard Palcoux, Jean Christophe Bendini, Jean Claude Aldigier, Jean Claude Alphonse, Jean Daniel Delbet, Jean Francois Bonne, Jean Francois Cantin, Jean Francois De Fremont, Jean Francois Dessassis, Jean Francois Subra, Jean Francois Valentin, Jean Francois Verdier, Jean Jacques Dion, Jean Jacques Haultier, Jean Jacques Montseny, Jean Louis Bacri, Jean Louis Bouchet, Jean Luc Mahe, Jean Marc Chalopin, Jean Marc Gabriel, Jean Marc Hurot, Jean Marc Lanau, Jean Marie Batho, Jean Marie Coulibaly, Jean Michel Hardin, Jean Michel Marc, Jean Michel Poux, Jean Michel Rebibou, Jean Michel Tivollier, Jean Noel Ottavioli, Jean Paul Faucon, Jean Paul Imiela, Jean Paul Jaulin, Jean Paul Masselot, Jean Paul Ortiz, Jean Philippe Bourdenx, Jean Philippe Devaux, Jean Philippe Hammelin, Jean Pierre Rivory, Jean Pierre Wauquier, Jean Rene Larue, Jean Rene Mondain, Jean Sebastien Borde, Jean Simon Virot, Jean Yves Bosc, Jedjiga Achiche, Jennifer Parasote, Jeremie Diolez, Jerome Harambat, Jerome Potier, Jerome Sampol, Jihad Mustel, Jean Jacques Lefevre, Jocelyne Maurizi, Joel Gamberoni, Joelle Claudeon, Joelle Terzic, Joffrey Rogol, Johnny Sayegh, Jorge Cardozo, Jose Brasseur, Jose Guiserix, Joseph Barsumau, Julie Albaret, Julie Beaume, Julie Sohier Attias, Julien Dehay, Julien Hogan, Julien Journet, Julien Ott, Juliette Baleynaud, Justine Bacchetta, Justine Faucher, Kamel Yousfi, Karim Dardim, Karine Clabault, Karine Moreau, Kedna Thomas, Khaled Sirajedine, Khalil Chedid, Khalil El Kaeoui, Khalil El Karoui, Khedidja Bouachi, Kheira Hue, Khuzama El Nasser, Kodso Akposso, Kristian Kunz, Krzysztof Bijak, Lilia Kihal, L. Rasoloarijaona, Laid Harbouche, Larbi Bencheikh, Larbie Lamriben, Latifa Hanafi, Laura Braun Parvez, Laure Champion, Laure Croze, Laure Eprinchard, Laure Patrier, Laurence Nicolet, Laurence Vrigneaud, Laurent Duflot, Leandre Mackaya, Leila Chenine, Leon Odry, Lili Taghipour Tamiji, Lilia Antri Bouzar, Liliane Ngango Nga Messi, Lionel Le Mouellic, Lise Mandart, Lise Weis, Lise Marie Pouteau, Lora Georgieva, Lorita Vitanova, Lotfi Chalabi, Luc Delvallez, Luc Fromentin, Luc Marty, Luc Monjot, Luciana Spataru, Lucie Bessenay, Lucie Boissinot, Lucie Wajsbrot, Lucien Rakoff, Ludivine Lebourg, Lydie Perez, Lyliane Lafage, Lynda Azzouz, Madeleine Dumoulin, Messaoud Ouziala, Maan Joseph, Mabrouk Brahimi, Maeva Wong Fat, Magalie Fort, Magued Nakhla, Mahdi Abtahi, Mahen Albadawy, Mahmoud Alouach, Mahmoud Mezghani, Maite Daroux, Maklouf Boukelmoune, Malek Dhib, Malik Touam, Malina Dubau, Mamadou Balde, Man Nguyen Khoa, Manfred Ismer, Manolie Mehdi, Manon Laforet, Marc Bouiller, Marc Eugene, Marc Fila, Marc Hazzan, Marc Kribs, Marc Ladriere, Marc Lebot, Marc Padilla, Marc Souid, Marcel Marraoui, Maren Burbach, Maria Manescu, Maria Eugenia Noguera Gonzalez, Mariana Revenco, Marianne Terrasse, Marie Essi, Marie Alice Macher, Marie Beatrice Nogier, Marie Cecile Cazin, Marie Christine Schweitzer Camoin, Marie Christine Thouret, Marie Claude Hannaert, Marie France Servel, Marie Helene Chabannier, Marie Jeanne Coudert Krier, Marie Noelle Catoliquot, Marie Paule Guillodo, Marie Sophie Gavard, Marie Xaviere Vairon Codaccioni, Marina Rabec, Marine Freist, Marion Gauthier, Marion Lemaire, Marion Mehrenberger, Marion Venot, Marios Pongas, Marlene Beaubrun Diant, Martial Levannier, Martine Bertaux, Mathieu Jablonski, Mathieu Sacquepee, Mathilde Dargelos, Mathilde Lemoine, Mathilde Tamain, Matthieu Monge, Matthieu Reberolle, Maud Cousin, Maud Francois, Maurice Baron, Maxime Hoffmann, Maxime Ingwiller, Maxime Touzot, Mederick Mohajer, Mehadji Maaz, Melanie Hanoy, Melanie Marroc, Melodie Cuny, Menno Van Der Straaten, Mf. Serveaux, Michel Basteri, Michel Fen Chong, Michel Hecht, Michel Massad, Michel Normand, Michel Olmer, Michel Tolani, Michel Tsimaratos, Michele Hemery, Michele Kessler, Miguel Esposito, Milad Shenouda, Mimi Kareche, Mina Khalili, Mirella Diaconita, Mohamad Khair Rifard, Mohamed Aladib, Mohamed Belmouaz, Mohamed Brahim, Mohamed Diouani, Mohamed Fodil Cherif, Mohamed Jamali, Mohamed Maghlaoua, Mohamed Meddeb, Mohamed Ramdane, Mohamed Rifaat, Mohamed Sharifull Islam, Mohamed Adnan Abbade, Mokhtar Amrandi, Mokhtar Chawki, Monica Ciobotaru, Monica Indrieis, Monique Chanas, Monique Hoarau, Monzer Tomeh, Moufida Bellou, Mouloud Bouzernidj, Mounia Ammor, Mounir Guergour, Mountassir Benzakour, Mourad Hachicha, Moussa Coulibaly, Mustafa Smati, Mustapha Al Morabiti, Mustapha Amirou, Myriam Isnard, Myriam Pastural, Myriam Pujo, Nourredine Boumendjel, Nabil Majbri, Nabila Goumri, Nadege Mingat, Nader Bassilios, Nadia Kerkeni, Nadia Sedrati, Nadia Soltani, Nadine Maroun, Nadine Neyrat, Nahn Luang, Najeh El Esper, Naji Ammar, Nasredine Ghali, Nasser Hamdini, Natacha Noel, Natacha Potelune, Nathalie Maisonneuve, Nathalie Pertuiset, Nathalie Raynal, Nathalie Vittoz, Nazim Terki, Nelly Castin, Nestor Nankeu, Nicolas Bouvier, Nicolas Keller, Nicolas Legros, Nicolas Peters, Nicolas Quirin, Nicole Lefrancois, Nicole Monnier, Nicole Rance, Niels Bruckmann, Noel Mertens, Nolwenn Lorcy, Olivia Gilbert, Olivier Coldefy, Olivier Drouineau, Olivier Dunand, Olivier Fritz, Olivier Imhoff, Olivier Kourilsky, Olivier Lavelle, Olivier Papin, Olivier Roques, Ophelie Le Maner, Oussamah Fikri Benbrahim, Pablo Antonio Erina Torres, Pablo Antonio Urena Torres, Paolo Malvezzi, Pascal Bindi, Pascal Cluzel, Pascal Fontanier, Pascal Wheatley, Pascale Depraetre, Pascale Dubosq, Pascale Halin, Pascale Sebahoun, Pascale Siohan, Pascale Testevuide, Patrice Deteix, Patrice Nolen, Patricia Hue, Patricia Lemarchand, Patrick Donnadieu, Patrick Fievet, Patrick Fohrer, Patrick Francais, Patrick Giraud, Patrick Hallonet, Patrick Henri, Patrick Michaut, Patrick Niaudet, Patrick Pauly, Patrick Thomas, Patrik Deleaval, Paul Finielz, Paul Stroumza, Paule Hardy Yverneau, Pauline Caillard, Pedro Palacin, Perrine Aubertin, Philippe Attias, Philippe Chauveau, Philippe Coindre, Philippe Coste, Philippe Dubot, Philippe Fournier, Philippe Hiernaux, Philippe Jousset, Philippe Lan Yue Wah, Philippe Lang, Philippe Le Cacheux, Philippe Martin Dupont, Philippe Michel, Philippe Mirgaine, Philippe Moriniere, Philippe Nicoud, Philippe Rieu, Philippe Rousseau, Philippe Sporer, Philippe Thorel, Philippe Vanhille, Philippe Vigeral, Philippe Zaoui, Pierre Bataille, Pierre Brignon, Pierre Filipozzi, Pierre Housset, Pierre Peyronnet, Pierre Ramperez, Pierre Vautrin, Pierre Alexandre Michel, Pierre Francois Westeel, Pierre Louis Carron, Pierre Yves Durand, Pierrot Parent, Piotr Seniuta, François Kuentz, Rabah Fraoui, Rachel Tetaz, Rachid Amaria, Rachid Bourouma, Rachid Djeffal, Rachida Nebbad, Radia Allal, Radu Dimulescu, Rafaat Boustani, Rafik Mesbah, Raifat Makdassi, Raji Diab, Raluca Puslenghea, Raoul Roura, Rateb Khayat, Raymond Azar, Raymond Frayssinet, Regine Monkam, Rehouni Boulahrouz, Remi Boudet, Renato Demontis, Renaud Gansey, Rene Cuvelier, Renee Schmitt, Reschad Noordally, Reynald Binaut, Rezkallah Latif, Richard Dufresne, Richard Montagnac, Richard Reade, Robert Genin, Robert Novo, Rocsana Fickl, Roger Dufresne, Roger Magnol, Roland Issautier, Romain Mortelette, Ronan Delaval, Ronan Lohro, Roseline M'barga, S. Beau, Clémentine Dupuis, Marie Jacques Vidil, Sabria Hacini, Said Dahmoune, Saliha Lekhal, Salima Ahriz Sakso, Salima Saksi, Salvatore Citarda, Samir Boubenider, Samuel Kassis, Sandra Verhille, Sandrine Genestier, Sandrine Muller, Saoussen Krid, Sarah Richter, Sebastien Delbes, Sebastien Mailliez, Sebastien Veillon, Sébastien Nony, Seddick Benarbia, Severine Beaudreuil, Sidi Ali Benyaghla, Simon Duquennoy, Simona Baluta, Simona Boncila, Sonia Mzoughi, Sonia Ribal, Sophie Acamer, Sophie Chauvet, Sophie Girerd, Sophie Ozenne, Sophie Parahy, Sophie Rubens Duval, Sophie Taque, Soraya Menouer, Soumaya Chargui, Stanislas Bataille, Stephane Barbier, Stephane Billion, Stephane Roueff, Stephane Torner, Stephane Jean Martin, Stephanie Coupel, Sylvie Cloarec, Sylvie Lavaud, Sylvie Leou, T. Chatelet, Tania Onesta, Tassadit Benhabib, Tayeb Bensalem, Theodora Dimulescu, Theophile Sawadogo, Thibault Dolley Hitze, Thierry Baranger, Thierry Boudemaghe, Thierry Hannedouche, Thierry Krummel, Thierry Milcent, Thomas Dervaux, Thomas Guincestre, Thomas Kofman, Thomas Raphael, Thomas Sadreux, Tim Ulinski, Tiphaine Guyon Roger, Tomas Serrato, Tomek Kofman, Tony Wong, Toufik Boubia, Ubald Assogba Gbindoun, Usama Khuzaie, Valerie Caudwell, Valerie Chatelet, Valerie Crougneau, Valerie De Precigout, Valerie Drouillat, Valerie Galantine, Valerie Granveau Hugot, Valerie Leroy, Veronique Boubia, Veronique Falque, Veronique Fournier, Veronique Queron, Veronique Viviani, Victor Gueuttin, Victor Panescu, Victorio Menoyo Calonge, Viet Nguyen, Vincent Allot, Vincent Delattre, Vincent Leduc, Vincent Pradier, Violaine Emal Aglae, Viorica Badulescu, Virginia Molina, Virginie Besson, Virginie Chaigne, Waddah Jaber, Wael Boudi, Wael El Haggan, Wen Qin Guillon, Wided Tabbi Aneni, William Hanf, Wladimir Kohn, Xavier Bellenfant, Xavier Moreau Gaudry, Yahsou Delmas, Yannick Knefati, Yannick Saingra, Yannick Tirolien, Youssef Mann, Yvan Brunak, Yves Dimitrov, Yves Doussy, Yves Tanter, Zaid Benabid, Zaara Soltani, Zacharia Boukerroucha, Zafer Takla, Zana Ramanantsialonina, Zara Dickson, Zead Tubail, Zoe Koochaki Pour, Zohra Boukhalfa, Zohra Jacquot, Agence de la biomédecine [Saint-Denis la Plaine], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université de Caen Normandie (UNICAEN), Normandie Université (NU), CALYDIAL Vienne, Partenaires INRAE, Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Armand Trousseau [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] (Pôle S2R), Centre Universitaire des Maladies Rénales [CHU Caen] (CUMR Caen), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Groupe hospitalier de la région de Mulhouse Sud-Alsace (GHRMSA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Assistance Publique - Hôpitaux de Marseille (APHM), Service de diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Service de Diabétologie [CHU Pitié-Salpétrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
0301 basic medicine, Male, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Hemodialysis, Home, Disease, MESH: COVID-19 / therapy, registry, Ambulatory Care Facilities, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, MESH: Aged, 80 and over, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Risk Factors, 80 and over, Prevalence, covid, dialysis, epidemiology, mortality, Aged, Aged, 80 and over, COVID-19, Case-Control Studies, Critical Care, Female, France, Humans, Incidence, Middle Aged, Patient Acuity, Protective Factors, Registries, Renal Dialysis, SARS-CoV-2, Sex Factors, Hypoalbuminemia, MESH: France / epidemiology, education.field_of_study, Incidence (epidemiology), 3. Good health, MESH: COVID-19 / epidemiology, Nephrology, Hemodialysis, medicine.medical_specialty, Population, Lower risk, Article, 03 medical and health sciences, MESH: Sex Factors, Internal medicine, medicine, MESH: SARS-CoV-2, MESH: Renal Dialysis / statistics & numerical data, education, Dialysis, Vascular disease, business.industry, medicine.disease, Former Smoker, MESH: Critical Care / statistics & numerical data, 030104 developmental biology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Home, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MESH: Hemodialysis, Home / statistics & numerical data
Abstract

The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed., Graphical abstract

Published
2020

6. Dynapaenia and sarcopaenia in chronic haemodialysis patients: do muscle weakness and atrophy similarly influence poor outcome?

Author

Fabrice Raynaud, Annie Rodriguez, Lotfi Chalabi, Laure Patrier, Jacques Mercier, Isabelle Ohresser, Nils Kuster, Moglie Le Quintrec, Fares Gouzi, Eric Badia, Grégoire Pasquier, Jean-Sébastien Souweine, Jean-Paul Cristol, Marion Morena, Maurice Hayot, Nathalie Raynal, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and MORNET, Dominique

Subjects
Male, medicine.medical_specialty, Weakness, Sarcopenia, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine.medical_treatment, 030232 urology & nephrology, 030204 cardiovascular system & hematology, sarcopenia, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Renal Dialysis, Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Prospective Studies, 10. No inequality, Prospective cohort study, Dialysis, Aged, Transplantation, Muscle Weakness, business.industry, chronic haemodialysis, Muscle weakness, dynapenia, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Muscle atrophy, Muscular Atrophy, muscle mass, Nephrology, Creatinine, muscle strength, Kidney Failure, Chronic, Hemodialysis, medicine.symptom, business
Abstract

Background Sarcopaenia, defined as a decline in both muscle mass and function, has been recognized as a major determinant of poor outcome in haemodialysis (HD) patients. It is generally assumed that sarcopaenia is driven by muscle atrophy related to protein-energy wasting. However, dynapaenia, defined as weakness without atrophy, has been characterized by a different disease phenotype from sarcopaenia. The aim of this study was to compare the characteristics and prognosis of sarcopaenic and dynapaenic patients among a prospective cohort of chronic HD (CHD) patients. Methods Two hundred and thirty-two CHD patients were enrolled from January to July 2016 and then followed prospectively until December 2018. At inclusion, weakness and atrophy were, respectively, evaluated by maximal voluntary force (MVF) and creatinine index (CI). Sarcopaenia was defined as the association of weakness and atrophy (MVF and CI below the median) while dynapaenia was defined as weakness not related to atrophy (MVF below the median, and CI above the median). Results From a total of 187 prevalent CHD patients [65% of men, age 65.3 (49.7–82.0) years], 44 died during the follow-up period of 23.7 (12.4–34.9) months. Sarcopaenia and dynapaenia were observed in 33.7 and 16% of the patients, respectively. Compared with patients with sarcopaenia, patients with dynapaenia were younger and with a lower Charlson score. In contrast, mortality rate was similar in both groups (38 and 27%, respectively). After adjustment for age, sex, lean tissue index, serum albumin, high-sensitivity C-reactive protein (hs-CRP), haemoglobin (Hb), normalized protein catabolic rate (nPCR), dialysis vintage and Charlson score, only patients with dynapaenia were at increased risk of death [hazard ratio (HR) = 2.99, confidence interval 1.18–7.61; P = 0.02]. Conclusions Screening for muscle functionality is highly warranted to identify patients with muscle functional impairment without muscle atrophy. In contrast to sarcopaenia, dynapaenia should appear as a phenotype induced by uraemic milieu, characterized by young patients with low Charlson score and poor prognosis outcome independently of serum albumin, hs-CRP, Hb, nPCR and dialysis vintage.

Published
2020

7. Hémodiafiltration en ligne : modalités pratiques, sécurité et efficacité de la méthode

Author

Laure Patrier, Annie Rodriguez, Bernard Canaud, Hélène Leray-Moragues, Leila Chenine, A. Gontier-Picard, Marion Morena, Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Anemia, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Urology, 030204 cardiovascular system & hematology, Mortalité, 03 medical and health sciences, 0302 clinical medicine, High efficiency renal replacement therapy, Chronic kidney disease, Substitution volume, Medicine, Insuffisance rénale chronique, Renal replacement therapy, Mortality, Prospective cohort study, Dialysis, ComputingMilieux_MISCELLANEOUS, Hémodiafiltration en ligne, Dialyse, business.industry, Online hemodiafiltration, medicine.disease, 3. Good health, Nephrology, Hemodialysis, business, Suppléance rénale de haute efficacité, Cohort study
Abstract

Purification of high molecular uremic toxins by conventional hemodialysis is limited. It remains associated with a high morbidity and excessively high mortality. Online hemodiafiltration using a high permeability hemodiafilter, an ultrapure dialysate, and which tends to maximize substitution volumes, provides a high efficiency and low bio-incompatibility renal supplementation. Regular use of online hemodiafiltration is associated with reduced morbidity (reduction of intradialytic hypotension episodes, improved blood pressure control, reduced inflammatory profile, better anemia correction and prevention of β2-microglobulin-associated amyloidosis). Recently, several cohort studies have shown that hemodiafiltration with high substitution volume was associated with a significant reduction in mortality. Randomized studies have been conducted in Europe to confirm these facts. The high safety of online hemodiafiltration has been confirmed in clinical practice by prospective studies. Online hemodiafiltration has reached its full maturity phase and is expected to represent the new standard of renal replacement therapy.

Published
2017

8. Hémodiafiltration en ligne : modalités pratiques, sécurité et efficacité de la méthode

Author

Bernard, Canaud, Leïla, Chénine, Hélène, Leray-Moraguès, Laure, Patrier, Annie, Rodriguez, A, Gontier-Picard, Marion, Moréna, Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and MORNET, Dominique

Subjects
Hémodiafiltration en ligne, Evidence-Based Medicine, Time Factors, Dialyse, [SDV]Life Sciences [q-bio], Hemodiafiltration, Mortalité, Online hemodiafiltration, [SDV] Life Sciences [q-bio], Treatment Outcome, High efficiency renal replacement therapy, Chronic kidney disease, Quality of Life, Humans, Kidney Failure, Chronic, Insuffisance rénale chronique, Patient Safety, Mortality, Dialysis, ComputingMilieux_MISCELLANEOUS, Suppléance rénale de haute efficacité
Abstract

Purification of high molecular uremic toxins by conventional hemodialysis is limited. It remains associated with a high morbidity and excessively high mortality. Online hemodiafiltration using a high permeability hemodiafilter, an ultrapure dialysate, and which tends to maximize substitution volumes, provides a high efficiency and low bio-incompatibility renal supplementation. Regular use of online hemodiafiltration is associated with reduced morbidity (reduction of intradialytic hypotension episodes, improved blood pressure control, reduced inflammatory profile, better anemia correction and prevention of β

Published
2017

9. Treatment tolerance and patient-reported outcomes favor online hemodiafiltration compared to high-flux hemodialysis in the elderly

Author

Marion Morena, Audrey Jaussent, Lotfi Chalabi, Hélène Leray-Moragues, Leila Chenine, Alain Debure, Damien Thibaudin, Lynda Azzouz, Laure Patrier, Francois Maurice, Philippe Nicoud, Claude Durand, Bruno Seigneuric, Anne-Marie Dupuy, Marie-Christine Picot, Jean-Paul Cristol, Bernard Canaud, Aida Afiani, Didier Aguilera, Yamina Azymah, Francois Babinet, Claire Belloc, Jean- Christophe Bendini, Christian Broyet, Philippe Brunet, Marie-Hélène Chabannier, Leïla Chenine, Sylvie Chiron, Jean-Philippe Coindre, Angélique Colin, François Combarnous, Stéphanie Coupel, Alain Cremault, Irima Dancea, Catherine Delcroix, Pascale Depraetre, Assia Djema, Francis Ducret, Ibrahim Farah, Dominique Fleury, Abdallah Guerraoui, Marie-Paule Guillodo, Atman Haddj-Elmrabet, Maxime Hoffmann, Richard Ibos, Mohamed Shariful Islam, Dominique Jaubert, Josiane Joule, Véronique Joyeux, Kristian Kunz, Mélodie Lagarrigue, Achour Laradi, Frédéric Lavainne, Dominique Le Grignou, Gaétan Lebrun, Anne Lefebvre, Jean-Jacques Lefevre, Gaëlle Lefrancois, Vincent Lemaitre, Mehadji Maaz, Eric Magnant, François Maurice, Hesham Mohey, Michel Normand, Hilaire Nzeyimana, Messaoud Ouziala, Sophie Parahy, Franck Perrin, Philippe Pointet, Jacky Potier, Olivier Puyoo, Isabelle Rey, Jean-Pierre Rivory, Fabienne Rouleau, Marie-Odile Serveaux, Danièle Simonin, Angelo Testa, Cécile Turc-Baron, Carlos Vela, Sandor Vido, Laurence Vrigneaud, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Saint-Etienne, Service de Néphrologie - Immunologie Clinique [Toulouse], CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse]-PRES Université de Toulouse, Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Université de Montpellier (UM), Herrada, Anthony, and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-PRES Université de Toulouse

Subjects
Male, Time Factors, medicine.medical_treatment, 030232 urology & nephrology, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Kidney, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, law.invention, 0302 clinical medicine, Randomized controlled trial, Quality of life, law, Risk of mortality, Prospective Studies, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, Age Factors, 3. Good health, Hospitalization, Treatment Outcome, Nephrology, Female, Kidney Diseases, France, Hemodialysis, medicine.symptom, safety, medicine.medical_specialty, Metabolic bone disease, 03 medical and health sciences, Renal Dialysis, Internal medicine, medicine, Humans, Intensive care medicine, Adverse effect, Geriatric Assessment, Aged, hemodiafiltration, intradialytic tolerance, business.industry, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, mortality, cardiovascular risk biomarkers, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Quality of Life, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, chronic kidney disease, Muscle cramp
Abstract

Large cohort studies suggest that high convective volumes associated with online hemodiafiltration may reduce the risk of mortality/morbidity compared to optimal high-flux hemodialysis. By contrast, intradialytic tolerance is not well studied. The aim of the FRENCHIE (French Convective versus Hemodialysis in Elderly) study was to compare high-flux hemodialysis and online hemodiafiltration in terms of intradialytic tolerance. In this prospective, open-label randomized controlled trial, 381 elderly chronic hemodialysis patients (over age 65) were randomly assigned in a one-to-one ratio to either high-flux hemodialysis or online hemodiafiltration. The primary outcome was intradialytic tolerance (day 30-day 120). Secondary outcomes included health-related quality of life, cardiovascular risk biomarkers, morbidity, and mortality. During the observational period for intradialytic tolerance, 85% and 84% of patients in high-flux hemodialysis and online hemodiafiltration arms, respectively, experienced at least one adverse event without significant difference between groups. As exploratory analysis, intradialytic tolerance was also studied, considering the sessions as a statistical unit according to treatment actually received. Over a total of 11,981 sessions, 2,935 were complicated by the occurrence of at least one adverse event, with a significantly lower occurrence in online hemodiafiltration with fewer episodes of intradialytic symptomatic hypotension and muscle cramps. By contrast, health-related quality of life, morbidity, and mortality were not different in both groups. An improvement in the control of metabolic bone disease biomarkers and β2-microglobulin level without change in serum albumin concentration was observed with online hemodiafiltration. Thus, overall outcomes favor online hemodiafiltration over high-flux hemodialysis in the elderly.

Published
2017

10. FGF-23 removal is improved by on-line high-efficiency hemodiafiltration compared to conventional high flux hemodialysis

Author

Lotfi Chalabi, Anne-Marie Dupuy, Laure Patrier, Bernard Canaud, Marion Morena, Jean-Paul Cristol, and Alexandre Granger Vallée

Subjects
Adult, Male, Fibroblast growth factor 23, medicine.medical_specialty, Time Factors, Polymers, medicine.medical_treatment, Treatment outcome, Urology, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Hemodiafiltration, Elisa kit, Renal Dialysis, medicine, Humans, In patient, Prospective Studies, Sulfones, Renal Insufficiency, Chronic, Prospective cohort study, Aged, Aged, 80 and over, business.industry, Membranes, Artificial, Equipment Design, Middle Aged, Surgery, Fibroblast Growth Factors, Fibroblast Growth Factor-23, High flux, Cross-Sectional Studies, Treatment Outcome, Nephrology, Linear Models, Female, Hemodialysis, business
Abstract

Background: Reducing circulating levels of fibroblast growth factor-23 (FGF-23) in patients on renal replace- ment therapy (RRT) could appear as an appealing ap- proach for cardiovascular events prevention. The pur- pose of our study was to compare the clearance of FGF-23 between high flux hemodialysis (HD) and on- line hemodiafiltration (OL-HDF) procedures. Methods: Fifty-three patients were included in the HD group while 32 patients were included in the OL-HDF group. Serum pre- and post-dialysis FGF-23 levels were measured using a 2 nd generation Human FGF-23 (C-Term) ELISA kit. Results: Mean FGF-23 reduction rates were significantly higher in OL-HDF (55.7±25.2%) versus HD (36.2±28.6%) groups (P=.0001), as were calculated FGF-23 clearanc- es (P=.015) and Kt/V-FGF-23 (P=.001). Overall, post- treatment FGF-23 levels were significantly lower than pre-treatment values in both groups (P

Published
2012

11. Prevention and Management of Dialysis Catheter Complications in the Intensive Care Unit

Author

Laure Patrier, Leila Chenine-Koualef, Paungpaga Lertdumrongluk, Hélène Leray-Moragues, Patrick Wilson, and Bernard Canaud

Subjects
medicine.medical_specialty, medicine.medical_treatment, urologic and male genital diseases, law.invention, law, Hospital discharge, Central Venous Catheters, Humans, Medicine, Renal replacement therapy, Intensive care medicine, Dialysis, business.industry, Acute kidney injury, Hematology, General Medicine, Dialysis catheter, Acute Kidney Injury, equipment and supplies, medicine.disease, Intensive care unit, female genital diseases and pregnancy complications, Renal Replacement Therapy, Intensive Care Units, Vascular network, Nephrology, business, Central venous catheter
Abstract

Dialysis dependence at hospital discharge after acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) is found in 10–15% of survivors. In case of severe AKI in the ICU, it is necessary to reconcile two objectives: the creation of an adequate temporary angioaccess for RRT and the preservation of the patient’s vascular network in case of evolution to end-stage renal disease. A central venous catheter (CVC) is the best option for RRT in the ICU setting. Most catheter-related hazards can be prevented by following best clinical practices for insertion and handling of the CVC, and by knowing the advantages and disadvantages of the different types of catheters, the sites and techniques of insertion, the types of RRT modality for choosing the best CVC option, and the prophylactic and therapeutic measures to prevent and to manage the complications. We review here some important aspects of the CVC for the treatment of AKI in the ICU.

Published
2012

12. SP677MUSCLE MASS ASSESSMENT BY CREATININE MODELING IMPROVES PROTEIN ENERGY WASTING

Author

Jean-Paul Cristol, Isabelle Ohresser, Leila Chenine, Georges Mourad, Grégoire Pasquier, Annie Rodriguez, Jean-Sébastien Souweine, Marion Morena, Laure Patrier, and Hélène Leray

Subjects
Transplantation, Creatinine, chemistry.chemical_compound, medicine.medical_specialty, chemistry, Nephrology, business.industry, Urology, Medicine, Protein energy wasting, business, medicine.disease, Cachexia
Published
2017

13. Online high-efficiency haemodiafiltration achieves higher serum free light chain removal than high-flux haemodialysis in multiple myeloma patients: preliminary quantitative study

Author

Jean-Paul Cristol, Leila Chenine, Bernard Canaud, Hélène Leray-Moragues, Chantal Cognot, Guillaume Cartron, Laure Patrier, and Alexandre Granger Vallée

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Urology, Hemodiafiltration, Convection, Immunoglobulin light chain, Online Systems, Nephropathy, Immunoglobulin lambda-Chains, Renal Dialysis, Serum free, hemic and lymphatic diseases, medicine, Substitution volume, Humans, Renal replacement therapy, Multiple myeloma, Retrospective Studies, Transplantation, integumentary system, business.industry, Middle Aged, Prognosis, medicine.disease, Surgery, High flux, Nephrology, Kidney Failure, Chronic, Female, Immunoglobulin Light Chains, Hemodialysis, Multiple Myeloma, business, Follow-Up Studies
Abstract

Background. Fast reduction of serum free light chain (FLC) levels correlate with renal recovery in cast nephropathy. Because convection has the capacity to remove proteins of higher molecular weights, we hypothesized that haemodiafiltration (HDF) would be superior to haemodialysis (HD) for FLC clearance. Methods. We retrospectively identified all renal replacement therapy (RRT) sessions performed in multiple myeloma patients with pre- and post-treatment FLC measurements during a 2-year period. Using kinetic modelling, we calculated reduction percentages corrected for net ultrafiltration, effective clearances, net mass removal and Kt/V for both kappa (j) and lambda (k) serum FLC. Results. We analysed 27 (10 HD and 17 HDF) RRT sessions realized in a total of six subjects. HDF resulted in higher FLC removal rates when compared to HD. Moreover, high-efficiency (i.e. substitution volume > 15 L/session) HDF demonstrated median efficient FLC clearances roughly twice superior to high-flux HD for both j (59.0 versus 33.8 mL/min, respectively; P < 0.01) and k (40.5 versus 19.7 mL/min, respectively; P ¼ 0.02) FLC. In postdilution HDF treatments, corrected FLC reduction percentages positively correlated with substitution volumes. Total plasma proteins increased during RRT in the HDF group. Conclusions. This preliminary quantitative study demonstrates the superiority of high-efficiency HDF over highflux HD for serum FLC removal in multiple myeloma patients on RRT. No negative impact on total plasma proteins was noted.

Published
2011

14. Cardiovascular risk stratification in hemodialysis patients in the era of highly sensitive troponins: should we choose between hs-troponin I and hs-troponin T?

Author

Stéphanie Badiou, François Maurice, Marion Morena, Gaelle Tachon, Hélène Leray-Moragues, Sebastien Deleuze, Lotfi Chalabi, Bouchra Badaoui, Nils Kuster, Laure Patrier, Jean-Paul Cristol, Bernard Canaud, Anne-Marie Dupuy, Anne-Sophie Bargnoux, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre hémodialyse Languedoc Méditerranée (CHLM), Centre hémodialyse Languedoc Méditerranée, CHU Henri Mondor, Association Installation à Domicile Epurations Rénales (AIDER), Centre Hémodialyse Languedoc Méditerranée, CHLM, and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 030213 general clinical medicine, Acute coronary syndrome, Pediatrics, medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Clinical Biochemistry, 030204 cardiovascular system & hematology, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Troponin complex, Troponin T, Renal Dialysis, Internal medicine, Troponin I, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Survival analysis, Aged, Aged, 80 and over, biology, business.industry, Biochemistry (medical), General Medicine, Middle Aged, medicine.disease, Troponin, 3. Good health, Highly sensitive, Cardiovascular Diseases, cardiovascular system, biology.protein, Cardiology, Female, Hemodialysis, business, Blood Chemical Analysis
Abstract

Background New highly sensitive (hs) assays have challenged the interpretation of cardiac troponins (cTn). The present study was designed to evaluate simultaneously conventional cTnT and cTnI together with their corresponding highly sensitive determinations in stable hemodialysis (HD) patients. Ability of cTn to stratify HD patient risk was assessed. Methods A total of 224 stable HD patients was included in this observational study. cTnT and hs-cTnT were measured using Roche cTnT/hs-cTnT assays based on a Cobas e601® analyzer. cTnI and hs-cTnI were measured using Beckman AccuTnI/hs-TnI IUO assays on Access II system. Patients were followed up prospectively during 9 years. Relationship between cTn level and mortality was assessed through Cox survival analysis. Results The median cTnT and cTnI concentrations were 38.5 ng/L (IQR, 18.8-76) and 10 ng/L (IQR, 10-20), respectively. The median hs-cTnT and hs-cTnI concentrations were 62.5 ng/L (IQR, 38.8-96.3) and 13.9 ng/L (IQR, 8.4-23.6), respectively. The prevalence of values above the 99th percentile was significantly more marked with cTnT (85.3 and 97.8% for conventional and hs cTnT, respectively) than with cTnI (7.6 and 67.4% for conventional and hs cTnI, respectively). During the follow-up, 167 patients died, mainly from cardiac cause (n=77). The optimized cut-off values, determined by bootstrap method, predicting mortality were 38, 69, 20 and 11 ng/L for cTnT, hs-cTnT, cTnI and hs-cTnI, respectively. After full adjustment, elevated plasma concentrations of all troponin were significant predictors of mortality. Conclusions A large proportion of patients free of acute coronary syndrome (ACS) has hs-cTn I or T higher than the 99th percentile which could be seen as a limiting factor for ACS screening. However, all generation and type of troponin assays could be reliable indicators of prognosis risk in HD patients.

Published
2015

15. La masse musculaire estimée par modèle cinétique de la créatinine améliore l’évaluation de la dénutrition protéinoénergétique

Author

Annie Rodriguez, H. Leray, Leila Chenine, I. Ohresser, J.S. Souweine, Laure Patrier, Jean-Paul Cristol, and G. Pasquier

Subjects
Nephrology
Abstract

Introduction La denutrition proteinoenergetique (DPE) est frequente chez les patients dialyses au long-court et est associee avec une morbidite et une mortalite accrue. Malgre tout, son evaluation reste difficile. Les scores de DPE, d’ARNOS et d’IPAQSS ont ete developpes dans ce but. Ils prennent en compte les differents compartiments corporels avec 3 parametres communs (albumine serique, Index de masse corporelle, apports proteiques) associes a l’index de creatinine (IC) pour le score de DPE, a la creatininemie normalisee par la surface corporelle (creatinine/SC) pour le score d’ARNOS et a la perte de poids a 6 mois pour le score d’IPAQSS. L’objectif de cette etude est de determiner le score le plus pertinent pour l’evaluation de la DPE chez les patients hemodialyses. Patients et methodes Les scores de DPE, d’ARNOS et d’IPAQSS ont ete calcules chez 157 patients hemodialyses (104H/53F, âge median : 68 [18–92]). De plus, l’index de creatinine (IC), la masse maigre corporelle (MMC) derivee de l’IC comme substitut de la masse musculaire et l’index de masse musculaire squelettique (IMMS) en impedancemetrie ont ete calcules. Resultats Les scores d’ARNOS et de DPE sont moderement concordants avec le score d’IPAQSS (respectivement coefficient kappa = 0,536, p kappa = 0,534, p kappa = 0,793, p r = 0,841, p r = 0,05, p = 0,5425), l’est faiblement avec l’IC ( r = 0,364, p r = 0,53, p Discussion Le score ARNOS et DPE semblent plus appropries que le Score IPAQSS pour evaluer la DPE precoce chez les patients dialyses. Conclusion Neanmoins, la masse musculaire estimee par l’IC et mesuree par impedancemetrie sont discordants et necessitent des investigations futures dans une cohorte plus grande de patients hemodialyses.

Published
2017

16. SP679PHYSICAL ACTIVITY AND MALNUTRITION INFLAMMATION COMPLEX SYNDROME CONSPIRE TO MUSCLE WEAKNESS AND ATROPHY IN HAEMODIALYSiS

Author

Moglie Le Quintrec, Hélène Leray, Maurice Hayot, Georges Mourad, Jean Sébastien Souweine, Annie Rodriguez, Fares Gouzi, Eric Badia, Nils Kuster, Leila Chenine, Laure Patrier, Marion Morena, and Jean-Paul Cristol

Subjects
Transplantation, medicine.medical_specialty, Malnutrition–inflammation complex, business.industry, Muscle weakness, medicine.disease, Gastroenterology, Atrophy, Nephrology, Internal medicine, Physical therapy, Medicine, medicine.symptom, business
Published
2017

17. On-Line Hemodialysis Monitoring: New Tools for Improving Safety, Tolerance and Efficacy

Author

Alexandre Granger, Laure Patrier, Leila Chenine-Khoualef, Hélène Leray-Moragues, Bernard Canaud, and Marion Morena

Subjects
medicine.medical_specialty, Dialysis adequacy, Quality management, business.industry, medicine.medical_treatment, Clinical supervision, medicine.disease, medicine, Hemodialysis, Hemodynamic stability, Intensive care medicine, business, Quality assurance, Dialysis, Kidney disease
Abstract

Hemodialysis adequacy is a complex concept that encompasses largely the dialysis dose appraisal based on monthly blood-based urea Kt/V measurement. Renal replacement therapies should provide an efficient way to clear adequately larger molecular weight solutes, to restore normal salt, electrolytes and fluid balance, to correct salt-dependent hypertension, to improve hemodynamic stability and to reduce bio-incompatibility of the hemodialysis system. Targeting such ambitious objective is obviously under the clinical supervision and judgment of nephrologists and care givers. Monitoring and achievement of these targets as a part of a continuous quality improvement process is necessary to attain dialysis adequacy goals. This review aims to provide an overview of available online hemodialysis technologies, their current applications in clinic, and the potential for future developments in improving care of chronic kidney disease patients. In order to facilitate understanding of readers we choose to classify online monitoring devices based on their clinical action.

Published
2013

18. [Hemodialysis in patients with chronic renal insufficiency]

Author

Bernard, Canaud, Hélène, Leray-Moragués, Leila, Chenine-Koualef, and Laure, Patrier

Subjects
Survival Rate, Time Factors, Treatment Outcome, Waiting Lists, Renal Dialysis, Risk Factors, Hemodialysis, Home, Humans, Kidney Failure, Chronic, France, Renal Insufficiency, Chronic, Kidney Transplantation, Monitoring, Physiologic
Abstract

Hemodialysis is the most advanced form of artificial renal support. It ensures the survival of almost 2 million patients wordwide. Considerable progress has been made in recent years thanks to a better understanding of uremia, optimization of treatment modalities and more personalized treatment schedules. Increase of uremic toxins removal, improvement of hemodynamic tolerance of the sessions, reduction of proinflammatory reactions due to the bioincompatibility system are major advances that may explain the reduction of morbidity and mortality in dialysis patients. New technologies (nanotechnology, biotechnology, microelectronics) are now expected to introduce further progresses by miniaturizing devices and providing them with an "artificial intelligence" capable of interacting with the patient. The main obstacle remains ageing of uremic patients, increasing prevalence of comorbidities and shortage of social resources that are not conducive to innovation. By promoting a more physiological, longer and more effective hemodialysis performed at home with help of teledialysis monitoring that would probably be an interesting option to evaluate on a medico-economical point of view.

Published
2012

19. HDL proteome in hemodialysis patients: a quantitative nanoflow liquid chromatography-tandem mass spectrometry approach

Author

Aurélie Goux, Bernard Canaud, Stéphanie Badiou, Alain Mangé, Jérôme Solassol, Laure Patrier, Thierry Maudelonde, and Jean-Paul Cristol

Subjects
Male, Proteomics, Apolipoprotein B, Proteome, lcsh:Medicine, Cardiovascular, Biochemistry, chemistry.chemical_compound, Cation homeostasis, Pathology, Medicine, Nanotechnology, lcsh:Science, Chromatography, High Pressure Liquid, Multidisciplinary, biology, Reverse cholesterol transport, Transferrin, Middle Aged, Nephrology, lipids (amino acids, peptides, and proteins), Female, Research Article, medicine.medical_specialty, Lipoproteins, Quantitative proteomics, Renal Dialysis, Diagnostic Medicine, Internal medicine, Humans, Lipoprotein oxidation, Biology, Aged, Apolipoprotein C-III, Haptoglobins, Cholesterol, business.industry, lcsh:R, Cholesterol, HDL, Proteins, Endocrinology, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, Kidney Failure, Chronic, lcsh:Q, Apolipoprotein C-II, business, Lipoprotein, General Pathology
Abstract

Aside from a decrease in the high-density lipoprotein (HDL) cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV) risk in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis (HD). Dysfunctional HDL leads to an alteration of reverse cholesterol transport and the antioxidant and anti-inflammatory properties of HDL. In this study, a quantitative proteomics approach, based on iTRAQ labeling and nanoflow liquid chromatography mass spectrometry analysis, was used to generate detailed data on HDL-associated proteins. The HDL composition was compared between seven chronic HD patients and a pool of seven healthy controls. To confirm the proteomics results, specific biochemical assays were then performed in triplicate in the 14 samples as well as 46 sex-matched independent chronic HD patients and healthy volunteers. Of the 122 proteins identified in the HDL fraction, 40 were differentially expressed between the healthy volunteers and the HD patients. These proteins are involved in many HDL functions, including lipid metabolism, the acute inflammatory response, complement activation, the regulation of lipoprotein oxidation, and metal cation homeostasis. Among the identified proteins, apolipoprotein C-II and apolipoprotein C-III were significantly increased in the HDL fraction of HD patients whereas serotransferrin was decreased. In this study, we identified new markers of potential relevance to the pathways linked to HDL dysfunction in HD. Proteomic analysis of the HDL fraction provides an efficient method to identify new and uncharacterized candidate biomarkers of CV risk in HD patients.

Published
2011

20. Reduced glomerular filtration rate, inflammation and HDL cholesterol as main determinants of superoxide production in non-dialysis chronic kidney disease patients

Author

Jean-Paul Cristol, Laure Patrier, Anne-Marie Dupuy, Anne-Sophie Bargnoux, Isabelle Jaussent, Marion Morena, Hélène Leray-Moragues, Kada Klouche, Stéphanie Badiou, and Bernard Canaud

Subjects
Adult, Male, medicine.medical_specialty, Population, Renal function, urologic and male genital diseases, Fibrinogen, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Superoxides, Internal medicine, medicine, Humans, education, Homocysteine, Aged, Aged, 80 and over, Inflammation, education.field_of_study, Chemistry, Superoxide, Cholesterol, Cholesterol, HDL, Case-control study, General Medicine, Middle Aged, medicine.disease, Creatine, Endocrinology, Case-Control Studies, Multivariate Analysis, Kidney Failure, Chronic, Female, Oxidative stress, Biomarkers, Kidney disease, medicine.drug, Glomerular Filtration Rate
Abstract

Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O(2)(•-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O(2)(•-) determinants in this population. O(2)(•-) production was evaluated using chemiluminescence method in 136 CKD patients (79M/57F, median age: 69.5 [27.4-94.6]). Renal function (evaluated by the glomerular filtration rate using modification of diet in renal disease (MDRD)), inflammation, lipids, nutritional and bone mineral as well as clinical parameters were evaluated. Potential relationships between O(2)(•-) and these clinico-biological parameters were investigated to identify main determinants of such a pathological process. Enhanced O(2)(•-) production has been observed at the pre-dialysis phase: stages 4 and 5 of CKD (p = 0.0065). In multivariate analysis, low eGFR (MDRD

Published
2011

22. Hemolytic uremic syndrome: an unusual complication of interferon-β treatment in a MS patient

Author

Mahmoud Charif, Elodie Nerrant, Laure Patrier, Anne-Sophie Ramay, Dimitri Renard, Pierre Labauge, Nicolas Menjot de Champfleur, and Hélène Perrochia

Subjects
Hemolytic anemia, medicine.medical_specialty, Neurology, business.industry, Multiple sclerosis, Thrombotic thrombocytopenic purpura, Posterior reversible encephalopathy syndrome, medicine.disease, Gastroenterology, Interferon β, Internal medicine, medicine, Neurology (clinical), business, Complication, Neuroradiology
Published
2013

23. Bone disease in CKD 5D

Author

Adrian Zugravu, Emre Tutal, Ananda Sen, Clorinda Derosa, Vincent Pichette, Jesus Montenegro, Zeynep Bal, Yukie Kitajima, Annie-Claire Nadeau-Fredette, A. Junqué, Miroslaw Kroczak, Nathan W. Levin, Monika Mlot-Michalska, Yoshihiro Onishi, Angel L.M. de Francisco, Manuel Casado, Young Ki Son, Anna Lucia Di Turo, Hana Novotná, Zeki Tonbul, Antonio Bordils, Oana Schiller, Anne-Marie Dupuis, Andrea Bruno, Francesca Tentori, Cristóbal Vicent, Marjan Mohanna, Won Suk An, Władysław Sułowicz, Beatrix Büschges-Seraphin, Ilaria Petrucci, M. Ramirez de Arellano, Domenico Chimienti, Violeta Roman, Takashi Akiba, Cristina Marelli, Tadao Akizawa, Mario Meola, Pasquale Libutti, Soledad Crucelegui, Shunichi Fukuhara, Senji Okuno, Pablo Bevione, Laura Rosales, Luigi Vernaglione, Hae Rahn Bae, Naoki Tsuboniwa, Angelo Karaboyas, Cesar E. Bogado, Seong Eun Kim, Takeshi Hasegawa, Antonio Crespo, Laure Patrier, Denis Ouimet, Nurhan Ozdemir Acar, José Lacueva, Olynka Vega, Alicja E. Grzegorzewska, Masaaki Inaba, Elisa E. Del Valle, Robert Bell, Marcelo Puddu, Crina Raletchi, Elisa Del Valle, Pei-Chun Chiang, Ing-Ching Jong, Marek Kuzniewski, Bruce M. Robinson, Marina Bravo, Friedrich Schulze, Pedro Ponce, Tom Depner, Zsofia Ivacson, Lofti Chalabi, Josep Mora, Hitoshi Nakayama, F. Nurhan Ozdemir Acar, František Švára, Juergen Bommer, Sara Samoni, Yongsoon Park, Dorota Pawlica, Kiyoshi Kurokawa, Rosamund Wilson, A. Sanchez Ramos, Harumi Ogawa, Carlo Lomonte, Eva Sedlácková, Ki Hyun Kim, Carlo Basile, Masashi Suzuki, Alexandre Granger Vallée, V. Duarte, M. Pou, M. Fulquet, Adrian Covic, J. Brian Copley, Myriam Lessard, Michel Vallée, Taeko Takahashi, Alicia Marini, Shigeichi Shoji, Hisaki Shimada, Peter Kotanko, Shigeru Miyazaki, Nicola Losurdo, Joy Mallari, Len A. Usvyat, Mª Teresa González, Ryo Kido, V. Esteve, Lynne Poole, Siren Sezer, Adamasco Cupisti, Noriko Saito, María B. Zanchetta, Yalcin Solak, Bogdan Solnica, Cristina Anghel, Francesco Casucci, Eiji Ishimura, Annalisa Teutonico, Hans-Juergen Arens, Guillermo Rosa Diez, Shinji Sakai, Rosario Moreno, Takuhiro Yamaguchi, Vladimír Polakovic, Jean-Philippe Lafrance, Hiroshi Kikuchi, Houshang Sanadgol, Jutta Passlick-Deetjen, Armando Luis Negri, Luis Sintado, Huseyin Atalay, Emilio González, Sebnem Karakan, Lisa Giovannini, Marisa Nobaru, Suzana Berca, K. Salas, Yuzuru Sato, Mahé Fernández, Mª Luisa Muñiz, Roberto Barone, Ligia Petrescu, Masafumi Fukagawa, Marcin Krzanowski, Carmen Anton, Mehtap Erkmen Uyar, Vicente Torregrosa, Jose R. Zanchetta, Peter Kaufmann, Jaime Ryba, Sheila Cayabyab, Friedrich K. Port, Bernard Canaud, Maurizio Antonelli, Katarzyna Janda, Carmen Santamaría, Danuta Fedak, Jorge Cannata, Tomoyuki Yamakawa, Beata Kusnierz-Cabala, Mª Dolores Arenas, Bogdan Stanescu, Carmen Barbulescu, Jean-Paul Cristol, Manfred Hecking, Mitsuru Ichii, Michael Smyth, Stephan Thijssen, Elisa Colombini, Jin Yeong Han, Erich Fradinger, M. Lavado, Francisco Ríos, Gabriel Mircescu, Helene Leray-Moragues, A. Saurina, Mahtab Baiani, Simona Stancu, Martine Leblanc, Patricia Peri, Kuan-Yu Hung, Leila Chenine, José Ignacio Merello, Marion Morena, Savino Cocola, Chih-Yen Hsiao, Carina Andrei, Simona Cinca, Adalbert Schiller, Fernando Silveira, Peir-Haur Hung, J. Macias, Manuel Canalis, José Mora, Barbara Marzell, and Berk Torun

Subjects
Transplantation, medicine.medical_specialty, Bone disease, Nephrology, business.industry, Internal medicine, medicine, medicine.disease, business
Published
2011

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