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1. Anti-mycobacterial activities of copper(II) complexes. Part II. Lipophilic hydroxypyridinones derived from maltol

Author

Katherine N. Robertson, Stephen A. Westcott, Andrew J. Flewelling, Lauren E. Salsbury, Hoaxin Li, Stephen J. Geier, Christopher A. Gray, and Christopher M. Vogels

Subjects
chemistry.chemical_compound, chemistry, Anti mycobacterial, Organic Chemistry, Maltol, chemistry.chemical_element, Organic chemistry, General Chemistry, Copper, Catalysis
Abstract

Eight lipophilic 3-hydroxy-4-pyridinones have been prepared from a microwave-mediated reaction along with the corresponding copper(II) complexes. All complexes have been obtained elementally pure and X-ray diffraction studies on two of the copper complexes have confirmed the structure of these compounds. Some of these complexes showed a promising degree of anti-mycobacterial activity against Mycobacterium tuberculosis, where activity seemed to vary by substitution at the pyridinone nitrogen atom.

Published
2015
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