11 results on '"Laurinaviciene, R."'
Search Results
2. Proton pump inhibitor-induced subacute cutaneous lupus erythematosus
- Author
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Sandholdt, L. H., Laurinaviciene, R., and Bygum, A.
- Published
- 2014
- Full Text
- View/download PDF
3. Diagnostic accuracy and interobserver concordance: teledermoscopy of 600 suspicious skin lesions in Southern Denmark
- Author
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Vestergaard, T., primary, Prasad, S.C., additional, Schuster, A., additional, Laurinaviciene, R., additional, Andersen, M.K., additional, and Bygum, A., additional
- Published
- 2020
- Full Text
- View/download PDF
4. Cutaneous lupus erythematosus: First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)
- Author
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Biazar, C. Sigges, J. Patsinakidis, N. Ruland, V. Amler, S. Bonsmann, G. Kuhn, A. Haust, M. Nyberg, F. Bata, Z. Mihályi, L. Olteanu, R. Pujol, R.M. Sánchez-Schmidt, J.M. Medenica, L. Skiljevic, D. Reich, A. Szepietowski, J.C. Dalle Vedove, C. Girolomoni, G. Hawro, T. Zalewska-Janowska, A. Glaeser, R. Huegel, R. Jedlicková, H. Bygum, A. Laurinaviciene, R. Benoit, S. Broecker, E. Bahmer, F.A. Aberer, E. Wutte, N. Lipozencic, J. Marinovic, B. Sárdy, M. Bekou, V. Ruzicka, T. Frances, C. Soutou, B. Lee, H. Worm, M. Gruschke, A. Hunzelmann, N. Steinbrink, K. Romiti, R. Sticherling, M. Erfurt-Berge, C. Avgerinou, G. Papafragkaki, D. Antiga, E. Caproni, M. Mayer, B. Volc-Platzer, B. Kreuter, A. Tigges, C. Heil, P.M. Stingl, G.
- Subjects
fungi - Abstract
In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males) patients with different subtypes of CLE, such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years and differed significantly between the CLE subtypes. In 347 (34.6%) of the 1002 patients, two or more CLE subtypes were diagnosed during the course of the disease and 453 (45.2%) presented with LE-nonspecific manifestations. Drug-induced CLE and SjögrenD́s Syndrome had the highest prevalence in SCLE patients (13.1% and 14.0%, respectively). Photosensitivity was significantly more frequent in patients with ACLE, SCLE, and ICLE compared with those with CCLE. The detection of antinuclear antibodies such as anti-Ro/SSA and anti-La/SSB antibodies revealed further significant differences between the CLE subtypes. In summary, the EUSCLE Core Set Questionnaire and its database facilitate the analysis of clinical and laboratory features in a high number of patients with CLE and will contribute to standardized assessment and monitoring of the disease in Europe. © 2012 Elsevier B.V.
- Published
- 2013
5. Cutaneous lupus erythematosus : First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)
- Author
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Biazar, C., Sigges, J., Patsinakidis, N., Ruland, V., Amler, S., Bonsmann, G., Kuhn, A., Haust, M., Nyberg, Filippa, Bata, Z., Mihályi, L., Olteanu, R., Pujol, R. M., Sánchez-Schmidt, J. M., Medenica, L., Skiljevic, D., Reich, A., Szepietowski, J. C., Dalle Vedove, C., Girolomoni, G., Hawro, T., Zalewska-Janowska, A., Glaeser, R., Huegel, R., Jedlicková, H., Bygum, A., Laurinaviciene, R., Benoit, S., Broecker, E., Bahmer, F. A., Aberer, E., Wutte, N., Lipozencic, J., Marinovic, B., Sárdy, M., Bekou, V., Ruzicka, T., Frances, C., Soutou, B., Lee, H., Worm, M., Gruschke, A., Hunzelmann, N., Steinbrink, K., Romiti, R., Sticherling, M., Erfurt-Berge, C., Avgerinou, G., Papafragkaki, D., Antiga, E., Caproni, M., Mayer, B., Volc-Platzer, B., Kreuter, A., Tigges, C., Heil, Peter Maximilian, Stingl, G., Biazar, C., Sigges, J., Patsinakidis, N., Ruland, V., Amler, S., Bonsmann, G., Kuhn, A., Haust, M., Nyberg, Filippa, Bata, Z., Mihályi, L., Olteanu, R., Pujol, R. M., Sánchez-Schmidt, J. M., Medenica, L., Skiljevic, D., Reich, A., Szepietowski, J. C., Dalle Vedove, C., Girolomoni, G., Hawro, T., Zalewska-Janowska, A., Glaeser, R., Huegel, R., Jedlicková, H., Bygum, A., Laurinaviciene, R., Benoit, S., Broecker, E., Bahmer, F. A., Aberer, E., Wutte, N., Lipozencic, J., Marinovic, B., Sárdy, M., Bekou, V., Ruzicka, T., Frances, C., Soutou, B., Lee, H., Worm, M., Gruschke, A., Hunzelmann, N., Steinbrink, K., Romiti, R., Sticherling, M., Erfurt-Berge, C., Avgerinou, G., Papafragkaki, D., Antiga, E., Caproni, M., Mayer, B., Volc-Platzer, B., Kreuter, A., Tigges, C., Heil, Peter Maximilian, and Stingl, G.
- Abstract
In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males) patients with different subtypes of CLE, such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years and differed significantly between the CLE subtypes. In 347 (34.6%) of the 1002 patients, two or more CLE subtypes were diagnosed during the course of the disease and 453 (45.2%) presented with LE-nonspecific manifestations. Drug-induced CLE and SjögrenD́s Syndrome had the highest prevalence in SCLE patients (13.1% and 14.0%, respectively). Photosensitivity was significantly more frequent in patients with ACLE, SCLE, and ICLE compared with those with CCLE. The detection of antinuclear antibodies such as anti-Ro/SSA and anti-La/SSB antibodies revealed further significant differences between the CLE subtypes. In summary, the EUSCLE Core Set Questionnaire and its database facilitate the analysis of clinical and laboratory features in a high number of patients with CLE and will contribute to standardized assessment and monitoring of the disease in Europe.
- Published
- 2013
- Full Text
- View/download PDF
6. Exostectomy for chronic midfoot plantar ulcer in Charcot deformity
- Author
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Laurinaviciene, R., Kirketerp-Moeller, K., Holstein, Per Evald, Laurinaviciene, R., Kirketerp-Moeller, K., and Holstein, Per Evald
- Abstract
Charcot midfoot ulcers are rare and very difficult to heal, with surgery being an option. This retrospective study assessed healing rates, complications, and the incidence of re-ulceration and other foot ulcer problems following exostectomies Udgivelsesdato: 2008/2
- Published
- 2008
7. Successful Treatment of Jessner’s Lymphocytic Infiltration of the Skin with Methotrexate
- Author
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Laurinaviciene, R, primary, Clemmensen, O, additional, and Bygum, A, additional
- Published
- 2009
- Full Text
- View/download PDF
8. Exostectomy for chronic midfoot plantar ulcer in Charcot deformity
- Author
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Laurinaviciene, R., primary, Kirketerp-Moeller, K., additional, and Holstein, P.E., additional
- Published
- 2008
- Full Text
- View/download PDF
9. Introducing teledermoscopy of possible skin cancers in general practice in Southern Denmark.
- Author
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Vestergaard T, Prasad SC, Schuster A, Laurinaviciene R, Bygum A, Munck A, and Andersen MK
- Subjects
- Adult, Denmark, Dermoscopy, Humans, General Practice, Melanoma diagnostic imaging, Skin Neoplasms diagnostic imaging
- Abstract
Background: The increasing incidence of skin cancers poses a burden to health care systems. General practitioners (GPs) play an important role in triaging these diseases and referring relevant patients to specialists. It is challenging to distinguish benign from malignant skin lesions, and GPs may benefit from diagnostic support from teledermoscopy (TD)., Objectives: To assess whether the introduction of TD in general practice was feasible and might reduce the number of unnecessary referrals to specialists and to assess the diagnostic accuracy and confidence of participating GPs., Methods: Fifty general practices in Southern Denmark participated. Adult patients presenting to their GP with suspected skin cancer could be included. Images including dermoscopy were taken by the GP and sent for evaluation by specialized dermatologists at a university hospital. Patients were simultaneously referred for a face-to-face evaluation at the university hospital. Diagnoses proposed by the GPs and by TD were compared to the final diagnoses obtained by histopathology or, if not available, face-to-face evaluation., Results: Five hundred and nineteen patients with 600 suspected skin cancers were included. The final diagnosis was benign in 72.3%. The photo quality was good or fair in 90.5%. GPs reported uncertainty about their diagnoses in 41.5% of cases. The GPs' positive predictive values for any malignancy and for malignant melanoma were 49.5% and 26.3%, respectively. On evaluation by TD, 31.5% of lesions did not need further in-person assessment., Conclusion: Useful images of suspicious skin lesions were obtained from general practice, and GPs could benefit from TD to improve their diagnostic accuracy and confidence., (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2020
- Full Text
- View/download PDF
10. Drug-induced cutaneous lupus erythematosus: 88 new cases.
- Author
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Laurinaviciene R, Sandholdt LH, and Bygum A
- Subjects
- Adult, Aged, Aged, 80 and over, Anticonvulsants adverse effects, Antineoplastic Agents adverse effects, Disease Progression, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Lupus Erythematosus, Cutaneous drug therapy, Male, Middle Aged, Retrospective Studies, Time Factors, Antifungal Agents adverse effects, Lupus Erythematosus, Cutaneous chemically induced, Proton Pump Inhibitors adverse effects, Sodium Chloride Symporter Inhibitors adverse effects
- Abstract
Background: An increasing number of drugs have been linked to drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). The recognition and management of DI-SCLE can be challenging, as the condition may be triggered by different classes of drugs after variable lengths of time., Objectives: To determine the proportion of patients with cutaneous lupus erythematosus (CLE) whose drugs are an inducing or aggravating factor., Materials & Methods: We conducted a retrospective chart review of patients diagnosed with CLE at a dermatological department over a 21-year period. We registered clinical, serological, and histological data with a focus on drug intake., Results: Of 775 consecutive patients with a diagnosis of lupus erythematosus (LE) or suspected LE, a diagnosis of CLE could be confirmed in 448 patients. A total of 130 patients had a drug intake that could suggest DI-SCLE. In 88 cases, a drug was evaluated to be definitely, probably, or possibly triggering CLE using the Naranjo probability scale. The most common drugs involved were proton pump inhibitors (PPIs), thiazide diuretics, antifungals, chemotherapeutics, statins, and antiepileptics. The incubation period varied widely with a median of eight weeks. The characteristics of DI-SCLE patients were more widespread rash relative to the other patients, with inflamed skin lesions or atypical variants which could resemble erythema multiforme., Conclusions: We present 88 patients with DI-SCLE, which is the largest case series reported, to date. DI-SCLE represented 20% of patients with CLE seen at our department. We conclude that DI-SCLE should be considered in every case of SCLE.
- Published
- 2017
- Full Text
- View/download PDF
11. New aspects in the clinical spectrum of neonatal lupus.
- Author
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Laurinaviciene R, Christesen HT, and Bygum A
- Subjects
- Female, Follow-Up Studies, Heart Block congenital, Heart Block etiology, Humans, Infant, Infant, Newborn, Lupus Erythematosus, Systemic complications, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic drug therapy, Pregnancy, Pregnancy Complications, Exanthema etiology, Lupus Erythematosus, Systemic congenital, Skin pathology
- Abstract
Neonatal lupus erythematosus (NLE) is a rare, passively acquired autoimmune disease, caused by maternal autoantibodies. Characteristic clinical features of NLE are transient rash and congenital heart block (CHB), but also hematological abnormalities and hepatobiliary dysfunction may occur. Complications to the transient dermatitis are rarely described. We describe two patients with NLE and cutaneous manifestations. Both patients had involvement of the sun-protected genital skin and soles. New manifestations of NLE were gastrointestinal bleeding in one patient despite normal coagulation parameters, but with mucosal telangiectatic lesions found on sigmoidoscopy. In addition, one patient developed painful atrophy after plantar dermatitis on follow-up with need of orthopedic footwear. CHB was not found. In conclusion, NLE may be complicated with sigmoidal telangiectasia with rectal bleeding and painful plantar atrophy.
- Published
- 2012
- Full Text
- View/download PDF
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