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264 results on '"Laursen, Henning"'

5. Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis—Convergence on axonal guidance

Author

Kaalund, Sanne S., Ven, Morten T., Bak, Mads, Mller, Rikke S., Laursen, Henning, Madsen, Flemming, Broholm, Helle, Quistorff, Bjrn, Uldall, Peter, Tommerup, Niels, Kauppinen, Sakari, Sabers, Anne, Fluiter, Kees, Mller, Lisbeth B., Nossent, Anne Y., Silahtaroglu, Asli, Kjems, Jrgen, Aronica, Eleonora, and Tümer, Zeynep

Published
2014
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30. Neurofilament inclusion body disease: a new proteinopathy?

Author

Josephs, Keith A., Holton, Janice L., Rossor, Martin N., Braendgaard, Hans, Ozawa, Tetsutaro, Fox, Nick C., Petersen, Ronald C., Pearl, Gary S., Ganguly, Milan, Rosa, Pedro, Laursen, Henning, Parisi, Joseph E., Waldemar, Gunhild, Quinn, Niall P., Dickson, Dennis W., and Revesz, Tamas

Published
2003

38. Tissue classification for the epidemiological assessment of surgical transmission of sporadic Creutzfeldt-Jakob disease. A proposal on hypothetical risk levels

Author

Calero Miguel, Siden Åke, Mølbak Kåre, de Pedro-Cuesta Jesús, Rábano Alberto, and Laursen Henning

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Epidemiological studies on the potential role of surgery in Creutzfeldt-Jakob Disease transmission have disclosed associations with history of specific surgical interventions or reported negative results. Methods Within the context of a case-control study designed to address surgical risk of sporadic Creutzfeldt-Jakob Disease in Nordic European countries (EUROSURGYCJD Project), a strategy was adopted to categorise reported surgical procedures in terms of potential risk of Creutzfeldt-Jakob Disease acquisition. We took into account elements of biological plausibility, either clinically or experimentally demonstrated, such as tissue infectivity, PrP expression content or successful route of infection. Results We propose a classification of exposed tissues and anatomic structures, drawn up on the basis of their specific putative role as entry site for prion transmission through contact with surgical instruments that are not fully decontaminated. Conclusions This classification can serve as a reference, both in our study and in further epidemiological research, for categorisation of surgical procedures in terms of risk level of Creutzfeldt-Jakob Disease acquisition.

Published
2005
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39. Sporadic Creutzfeldt-Jakob Disease in a Woman Married Into a Gerstmann-Sträussler-Scheinker Family: An Investigation of Prions Transmission via Microchimerism

Author

Areškevičiūtė, Aušrinė, primary, Melchior, Linea Cecilie, additional, Broholm, Helle, additional, Krarup, Lars-Henrik, additional, Lindquist, Suzanne Granhøj, additional, Johansen, Peter, additional, McKenzie, Neil, additional, Green, Alison, additional, Nielsen, Jørgen Erik, additional, Laursen, Henning, additional, and Lund, Eva Løbner, additional

Published
2018
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42. Surgery and Risk of Sporadic Creutzfeldt-Jakob Disease in Denmark and Sweden: Registry-Based Case-Control Studies

Author

Mahillo-Fernandez, Ignacio, Pedro-Cuesta, Jesus de, Bleda, Maria Jose, Cruz, Mabel, Mølbak, Kåre, Laursen, Henning, Falkenhorst, Gerhard, Martinez-Martin, Pablo, Siden, Ake, EUROSURGYCJD Research Group, European Commission, and Instituto de Salud Carlos III

Subjects
Male, medicine.medical_specialty, Time Factors, Epidemiology, Denmark, animal diseases, Disease, Creutzfeldt-Jakob Syndrome, Prion Diseases, Danish, Reference Values, mental disorders, medicine, Humans, Registries, Sweden, business.industry, Transmission (medicine), Case-control study, Transfusion Reaction, Sporadic Creutzfeldt-Jakob disease, Surgical procedures, Survival Analysis, language.human_language, nervous system diseases, Surgery, Case-Control Studies, Surgical Procedures, Operative, Reference values, language, Female, Neurology (clinical), Risk assessment, business
Abstract

BACKGROUND: Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial. METHODS: From Danish and Swedish registries we selected 167 definite and probable sCJD cases (with onset between 1987 and 2003) and 3,059 controls (835 age-, sex-, and residence-matched, and 2,224 unmatched). Independent of case/control status, surgical histories were obtained from National Hospital Discharge Registries. Surgical procedures were categorized by body system group and lag time to onset of sCJD. Exposure frequencies were compared using logistic regression. RESULTS: A history of any major surgery, conducted >/=20 years before sCJD onset, was more common in cases than both matched (OR = 2.44, 95% CI = 1.46-4.07) and unmatched controls (OR = 2.25, 95% CI = 1.48-3.44). This observation was corroborated by a linear increase in risk per surgical discharge (OR = 1.57, 95% CI = 1.13-2.18; OR = 1.50, 95% CI = 1.18-1.91). Surgery of various body systems, including peripheral vessels, digestive system and spleen, and female genital organs, was significantly associated with increased sCJD risk. CONCLUSIONS: A variety of major surgical procedures constitute a risk factor for sCJD following an incubation period of many years. A considerable number of sCJD cases may originate from health care-related accidental transmission. Funding was obtained from the EU Research Commission, Concerted Action QLRG3-CT-2002-81223, NEUROPRION and the Spanish RECSP C03-09, CIEN C03-06 and CIBERNED networks, and from the Karolinska and Carlos III National Health Institutes. Ethical evaluation was cleared by the KI Forskningsetikkommittee Syd (Dnr 452/02) on December 2, 2002. Preliminary results were presented at the EUROCJD/NEUROCJD Public Health EU meeting in Paris on December 5, 2006. J.P.-C. had full access to all study data, and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Published
2008

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