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1. OPAR: A Multicenter Phase II Randomized Trial of Fractionation Schedules for Once-a-Day Accelerated Partial Breast Irradiation (APBI)

Author

Kim, D.H., primary, Theberge, V., additional, Provencher, S., additional, Yassa, M., additional, Kong, I., additional, Perera, F.E., additional, Lavertu, S., additional, Rousseau, P., additional, Lee, J., additional, Karam, I., additional, Schneider, K., additional, Chambers, S., additional, Levine, M., additional, Parpia, S., additional, and Whelan, T.J., additional

Published
2021
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5. Abstract GS4-03: RAPID: A randomized trial of accelerated partial breast irradiation using 3-dimensional conformal radiotherapy (3D-CRT)

Author

Whelan, T, primary, Julian, J, additional, Levine, M, additional, Berrang, T, additional, Kim, D-H, additional, Gu, CS, additional, Germain, I, additional, Nichol, A, additional, Akra, M, additional, Lavertu, S, additional, Germain, F, additional, Fyles, A, additional, Trotter, T, additional, Perera, F, additional, Balkwill, S, additional, Chafe, S, additional, McGowan, T, additional, Muanza, T, additional, Beckham, W, additional, Chua, B, additional, and Olivotto, I, additional

Published
2019
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8. Canadian Surgery Forum1 Is laparoscopic sleeve gastrectomy a reasonable stand-alone procedure for super morbidly obese patients?2 Postoperative monitoring requirements of patients with obstructive sleep apnea undergoing bariatric surgery3 Role of relaparoscopy in the diagnosis and treatment of bariatric complications in the early postoperative period4 Changes of active and total ghrelin, GLP-1 and PYY following restrictive bariatric surgery and their impact on satiety: comparison of sleeve gastrectomy and adjustable gastric banding5 Prioritization and willingness to pay for bariatric surgery: the patient perspective6 Ventral hernia at the time of laparoscopic gastric bypass surgery: Should it be repaired?7 Linear stapled gastrojejunostomy with transverse handsewn enterotomy closure significantly reduces strictures for laparoscopic Roux-en-Y bypass8 Laparoscopic biliopancreatic diversion with duodenal switch as second stage for super super morbidly obese patients. Do all patients benefit?9 Sleeve gastrectomy in the super super morbidly obese (BMI > 60 kg/m2): a Canadian experience10 Laparoscopic gastric bypass for the treatment of refractory idiopathic gastroparesis: a report of 2 cases11 Duodeno-ileal switch as a primary bariatric and metabolic surgical option for the severely obese patient with comorbidities: review of a single-institution case series of duodeno-ileal intestinal bypass12 Management of large paraesophageal hernias in morbidly obese patients with laparoscopic sleeve gastrectomy: a case series13 Early results of the Ontario bariatric surgical program: using the bariatric registry14 Improving access to bariatric surgical care: Is universal health care the answer?15 Early and liberal postoperative exploration can reduce morbidity and mortality in patients undergoing bariatric surgery16 Withdrawn17 Identification and assessment of technical errors in laparoscopic Roux-en-Y gastric bypass18 A valid and reliable tool for assessment of surgical skill in laparoscopic Roux-en-Y gastric bypass19 Psychiatric predictors of presurgery drop-out following suitability assessment for bariatric surgery20 Predictors of outcomes following Roux-en-Y gastric bypass surgery at The Ottawa Hospital21 Prophylactic management of cholelithiasis in bariatric patients: Is routine cholecystectomy warranted?22 Early outcomes of Roux-en-Y gastric bypass in a publicly funded obesity program23 Similar incidence of gastrojejunal anastomotic stricture formation with hand-sewn and 21 mm circular stapler techniques during Roux-en-Y gastric bypass24 (CAGS Basic Science Award) Exogenous glucagon-like peptide-1 improves clinical, morphological and histological outcomes of intestinal adaptation in a distal-intestinal resection piglet model of short bowel syndrome25 (CAGS Clinical Research Award) Development and validation of a comprehensive curriculum to teach an advanced minimally invasive procedure: a randomized controlled trial26 Negative-pressure wound therapy (iVAC) on closed, high-risk incisions following abdominal wall reconstruction27 The impact of seed granting on research in the University of British Columbia Department of Surgery28 Quality of surgical care is inadequate for elderly patients29 Recurrence of inguinal hernia in general and hernia specialty hospitals in Ontario, Canada30 Oncostatin M receptor deficiency results in increased mortality in an intestinal ischemia reperfusion model in mice31 Laparoscopic repair of large paraesophageal hernias with anterior gastropexy: a multicentre trial32 Response to preoperative medical therapy predicts success of laparoscopic splenectomy for immune thrombocytopenic purpura33 Perioperative sepsis, but not hemorrhagic shock, promotes the development of cancer metastases in a murine model34 Measuring the impact of implementing an acute care surgery service on the management of acute biliary disease35 Patient flow and efficiency in an acute care surgery service36 The relationship between treatment factors and postoperative complications after radical surgery for rectal cancer37 Risk of ventral hernia after laparoscopic colon surgery38 Urinary metabolomics as a tool for early detection of Barrett’s and esophageal cancer39 Construct validity of individual and summary performance metrics associated with a computer-based laparo-scopic simulator40 Impact of a city-wide health system reorganization on emergency department visits in hospitals in surrounding communities41 Transcatheter aortic valve implantation for the nonoperative management of aortic stenosis: a cost-effectiveness analysis42 Breast cancer: racial differences in age of onset. A potential confounder in Canadian screening recommendations43 Risk taking in surgery: in and out of the comfort zone44 A tumour board in the office: Track those cancer patients!45 Increased patient BMI is not associated with advanced colon cancer stage or grade on presentation: a retrospective chart review46 Consensus statements regarding the multidisciplinary care of limb amputation patients in disasters or humanitarian emergencies. Report of the 2011 Humanitarian Action Summit Surgical Working Group on amputations following disasters or conflict47 Learning the CanMEDS role of professional: a pilot project of supervised discussion groups addressing the hidden curriculum48 Assessing the changing scope of training in Canadian general surgery programs: expected versus actual experience49 Predicting need for surgical management for massive gastrointestinal hemorrhage50 International health care experience: using CanMEDS to evaluate learning outcomes following a surgical mission in Mampong, Ghana51 The open abdomen: risk factors for mortality and rates of closure52 How surgeons think: an exploration of mental practice in surgical preparation53 The surgery wiki: a novel method for delivery of under-graduate surgical education54 Understanding surgical residents’ postoperative practices before implementing an enhanced recovery after surgery (ERAS) guideline at the University of Toronto55 From laparoscopic transabdominal to posterior retroperitoneal adrenalectomy: a paradigm shift in operative approach56 A retrospective audit of outcomes in patients over the age of 80 undergoing acute care abdominal surgery57 Canadian general surgery residents’ perspectives on work-hour regulations58 Timing of surgical intervention and its outcomes in acute appendicitis59 Preparing surgical trainees to deal with adverse events. An outline of learning issues60 Acute care surgical service: surgeon agreement at the time of handover61 Predicting discharge of elderly patients to prehospitalization residence following emergency general surgery62 Morbidity and mortality after emergency abdominal surgery in octo- and nonagenarians63 The impact of acute abdominal illness and urgent admission to hospital on the living situation of elderly patients64 A comparison of laparoscopic versus open subtotal gastrectomy for antral gastric adenocarcinoma: a North American perspective65 Minimally invasive excision of ectopic mediastinal parathyroid adenomas66 Perioperative outcomes of laparoscopic hernia repair in a tertiary care centre: a single institution’s experience67 Evaluation of a student-run, practical and didactic curriculum for preclerkship medical students68 Joseph Lister: Father of Modern Surgery69 Comparisons of melanoma sentinel lymph node biopsy prediction nomograms in a cohort of Canadian patients70 Local experience with myocutaneous flaps after extensive pelvic surgery71 The treatment of noncirrhotic splanchnic vein thrombosis: Is anticoagulation enough?72 Implementation of an acute care surgery service does not affect wait-times for elective cancer surgeries: an institutional experience73 Use of human collagen mesh for closure of a large abdominal wall defect, after colon cancer surgery, a case report74 The role of miR-200b in pulmonary hypoplasia associated with congenital diaphragmatic hernia75 Systematic review and meta-analysis of electrocautery versus scalpel for incising epidermis and dermis76 Accuracy of sentinel lymph node biopsy for early breast cancer in the community setting in St. John’s, New-foundland: results of a retrospective review77 Acute surgical outcomes in the 80 plus population78 The liberal use of platelets transfusions in the acute phase of trauma resuscitation: a systematic review79 Implementation of an acute care surgical on call program in a Canadian community hospital80 Short-term outcomes following paraesophageal hernia repair in the elderly patient81 First experience with single incision surgery: feasibility in the pediatric population and cost evaluation82 The impact of the establishment of an acute care surgery unit on the outcomes of appendectomies and cholecystectomies83 Description and preliminary evaluation of a low-cost simulator for training and evaluation of flexible endoscopic skills84 Tumour lysis syndrome in metastatic colon cancer: a case report85 Acute care surgery service model implementation study at a single institution86 Colonic disasters approached by emergent subtotal and total colectomy: lessons learned from 120 consecutive cases87 Acellular collagen matrix stent to protect bowel anastomoses88 Lessons we learned from preoperative MRI-guided wire localization of breast lesions: the University Health Network (UHN) experience89 Interim cost comparison for the use of platinum micro-coils in the operative localization of small peripheral lung nodules90 Routine barium esophagram has minimal impact on the postoperative management of patients undergoing esophagectomy for esophageal cancer91 Iron deficiency anemia is a common presenting issue with giant paraesophageal hernia and resolves following repair92 A randomized comparison of different ventilation strategies during thoracotomy and lung resection93 The Canadian Lung Volume Reduction Surgery study: an 8-year follow-up94 A comparison of minimally invasive versus open Ivor-Lewis esophagectomy95 A new paradigm in the follow-up after curative resection for lung cancer: minimal-dose CT scan allows for early detection of asymptomatic cancer activity96 Predictors of lymph node metastasis in early esophageal adenocarcinoma: Is endoscopic resection worth the risk?97 How well can thoracic surgery residents operate? Comparing resident and program director opinions98 The impact of extremes of age on short- and long-term outcomes following surgical resection of esophageal malignancy99 Epidermal growth factor receptor targeted gold nanoparticles for the enhanced radiation treatment of non–small cell lung cancer100 Laparoscopic Heller myotomy results in excellent outcomes in all subtypes of achalasia as defined by the Chicago classification101 Neoadjuvant chemoradiation versus surgery in managing esophageal cancer102 Quality of life postesophagectomy for cancer!103 The implementation, evolution and translocation of standardized clinical pathways can improve perioperative outcomes following surgical treatment of esophageal cancer104 A tissue-mimicking phantom for applications in thoracic surgical simulation105 Sublobar resection compared with lobectomy for early stage non–small cell lung cancer: a single institution study106 Not all reviews are equal: the quality of systematic reviews and meta-analyses in thoracic surgery107 Do postoperative complications affect health-related quality of life after video-assisted thoracoscopic lobectomy for patients with lung cancer? A cohort study108 Thoracoscopic plication for palliation of dyspnea secondary to unilateral diaphragmatic paralysis: A worthwhile venture?109 Thoracic surgery experience in Canadian general surgery residency programs110 Perioperative morbidity and pathologic response rates following neoadjuvant chemotherapy and chemoradiation for locally advanced esophageal carcinoma111 An enhanced recovery pathway reduces length of stay after esophagectomy112 Predictors of dysplastic and neoplastic progression of Barrett’s esophagus113 Recurrent esophageal cancer complicated by tracheoesophageal fistula: management by means of palliative airway stenting114 Pancreaticopleural fistula-induced empyema thoracis: principles and results of surgical management115 Prognostic factors of early postoperative mortality following right extended hepatectomy116 Optimizing steatotic livers for transplantation using a cell-penetrating peptide CPP-fused heme oxygenase117 Video outlining the technical steps for a robot-assisted laparoscopic pancreaticoduodenectomy118 Establishment of a collaborative group to conduct innovative clinical trials in Canada119 Hepatic resection for metastatic malignant melanoma: a systematic review and meta-analysis120 Acellular normothermic ex vivo liver perfusion for donor liver preservation121 Pancreatic cancer and predictors of survival: comparing the CA 19–9/bilirubin ratio with the McGill Brisbane Scoring System122 Staged liver resections for bilobar hepatic colorectal metastases: a single centre experience123 Economic model of observation versus immediate resection of hepatic adenomas124 Resection of colorectal liver metastasis in the elderly125 Acceptable long-term survival in patients undergoing liver resection for metastases from noncolorectal, non-neuroendocrine, nonsarcoma malignancies126 Patient and clinicopathological features and prognosis of CK19+ hepatocellular carcinomas: a case–control study127 The management of blunt hepatic trauma in the age of angioembolization: a single centre experience128 Liver resections for noncolorectal and non-neuroendocrine metastases: an evaluation of oncologic outcomes129 Developing an evidence-based clinical pathway for patients undergoing pancreaticoduodenectomy130 Hepatitis C infection and hepatocellular carcinoma in liver transplant: a 20 year experience131 The effect of medication on the risk of post-ERCP pancreatitis132 Temporal trends in the use of diagnostic imaging for patients with hepato-pancreato-biliary (HPB) conditions: How much ionizing radiation are we really using?196 A phase II study of aggressive metastasectomy for intra-and extrahepatic metastases from colorectal cancer133 Why do women choose mastectomy for breast cancer treatment? A conceptual framework for understanding surgical decision-making in early-stage breast cancer134 Synoptic operative reporting: documentation of quality of care data for rectal cancer surgery135 Learning curve analysis for cytoreductive surgery: a useful application of the cumulative sum (CUSUM) method136 Pancreatic cancer is strongly associated with a unique urinary metabolomic signature137 Concurrent neoadjuvant chemo/radiation in locally advanced breast cancer138 Impact of positron emission tomography on clinical staging of newly diagnosed rectal cancer: a specialized single centre retrospective study139 An evaluation of intraoperative Faxitron microradiography versus conventional specimen radiography for the excision of nonpalpable breast lesions140 Comparison of breast cancer treatment wait-times in the Southern Interior of British Columbia in 2006 and 2010141 Factors affecting lymph nodes harvest in colorectal carcinoma142 Laparoscopic adrenalectomy for metastases143 You have a message! Social networking as a motivator for fundamentals of laparoscopic surgery (FLS) training144 The evaluation and validation of a rapid diagnostic and support clinic for women assessment for breast cancer145 Oncoplastic breast surgery: oncologic benefits and limitations146 A qualitative study on rectal cancer patients’ preferences for location of surgical care147 The effect of surgery on local recurrence in young women with breast cancer148 Elevated IL-6 and IL-8 levels in tumour microenvironment is not associated with increased serum levels in humans with Pseudomyxoma peritonei and peritoneal mesothelioma149 Conversion from laparoscopic to open approach during gastrectomy: a population-based analysis150 A scoping review of surgical process improvement tools (SPITs) in cancer surgery151 Splenectomy during gastric cancer surgery: a population-based study152 Defining the polo-like kinase 4 (Plk4) interactome in cancer cell protrusions153 Neoadjuvant imatinib mesylate for locally advanced gastrointestinal stromal tumours154 Implementing results from ACOSOG Z0011: Practice-changing or practice-affirming?155 Should lymph node retrieval be a surgical quality indicator in colon cancer?156 Long-term outcomes following resection of retroperitoneal recurrence of colorectal cancer157 Clinical research in surgical oncology: an analysis of clinicaltrials.gov158 Radiation therapy after breast conserving surgery: When are we missing the mark?159 The accuracy of endorectal ultrasound in staging rectal lesions in patients undergoing transanal endoscopic microsurgery160 Quality improvement in gastrointestinal cancer surgery: expert panel recommendations for priority research areas161 Factors influencing the quality of local management of ductal carcinoma in situ: a cohort study162 Papillary thyroid microcarcinoma: Does size matter?163 Hyperthermic isolated limb perfusion for extremity soft tissue sarcomas: systematic review of clinical efficacy and quality assessment of reported trials164 Adherence to antiestrogen therapy in seniors with breast cancer: How well are we doing?165 Parathyroid carcinoma: Challenging the surgical dogma?166 A qualitative assessment of the journey to delayed breast reconstruction195 The role of yoga therapy in breast cancer patients167 Outcomes reported in comparative studies of surgical interventions168 Enhanced recovery pathways decrease length of stay following colorectal surgery, but how quickly do patients actually recover?169 The impact of complications on bed utilization after elective colorectal resection170 Impact of trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study171 Complex fistula-in-ano: Should the plug be abandoned in favour of the LIFT or BioLIFT?172 Prognostic utility of cyclooxygenase-2 expression by colon and rectal cancer173 Laparoscopic right hemicolectomy with complete mesocolic excision provides acceptable perioperative outcomes but is complex and time-consuming: analysis of learning curves for a novice minimally invasive surgeon174 Intraoperative quality assessment following double stapled circular colorectal anastomosis175 Improving patient outcomes through quality assessment of rectal cancer care176 Are physicians willing to accept a decrease in treatment effectiveness for improved functional outcomes for low rectal cancer?177 Turnbull-Cutait delayed coloanal anastomosis for the treatment of distal rectal cancer: a prospective cohort study178 Preoperative high-dose rate brachytherapy in preparation for sphincter preservation surgery for patients with advanced cancer of the lower rectum179 Impact of an enhanced recovery program on short-term outcomes after scheduled laparoscopic colon resection180 The clinical results of the Turnbull-Cutait delayed coloanal anastomosis: a systematic review181 Is a vertical rectus abdominus flap (VRAM) necessary? An analysis of perineal wound complications182 Fistula plug versus endorectal anal advancement flap for the treatment of high transsphincteric cryptoglandular anal fistulas: a systematic review and meta-analysis183 Maternal and neonatal outcomes following colorectal cancer surgery184 Transanal drainage to treat anastomotic leaks after low anterior resection for rectal cancer: a valuable option185 Trends in colon cancer in Ontario: 2002–2009186 Validation of electronically derived short-term outcomes in colorectal surgery187 A population-based assessment of transanal and endoscopic resection for adenocarcinoma of the rectum188 Laparoscopic colorectal surgery in the emergency setting: trends in the province of Ontario from 2002 to 2009189 Prevention of perineal hernia after laparoscopic and robotic abdominoperineal resection: review with case series of internal hernia through pelvic mesh which was placed in attempt to prevent perineal hernia190 Effect of rectal cancer treatments on quality of life191 The use of antibacterial sutures as an adjunctive preventative strategy for surgical site infection in Canada: an economic analysis192 Impact of socioeconomic status on colorectal cancer screening and stage at presentation: preliminary results of a population-based study from an urban Canadian centre193 Initial perioperative results of the first transanal endoscopic microsurgery (TEM) program in the province of Quebec194 Use of negative pressure wound therapy decreases perineal wound infections following abdominal perineal resection

Author

Fayez, R., primary, AlMuntashery, A., primary, Bodie, G., primary, Almamar, A., primary, Gill, R.S., primary, Raîche, I., primary, Mueller, C.L., primary, Moustarah, F., primary, Khokhotva, M., primary, Anvari, M., primary, Kwong, J., primary, Elkassem, S., primary, Bonrath, E., primary, Zevin, B., primary, Sockalingam, S., primary, Smith, C., primary, Whitlock, K.A., primary, Suri, M., primary, Palter, V.N., primary, Wakeam, E., primary, Khan, R.S.A., primary, Martelli, V., primary, Malik, A., primary, Young, P.Y., primary, Daigle, C., primary, McCreery, G., primary, Seth, R., primary, Paskar, D., primary, Sudarshan, M., primary, Richardson, D., primary, Haggar, F., primary, Davis, V.W., primary, Rivard, J., primary, Agzarian, J., primary, Racz, J., primary, Winocour, J., primary, Zilbert, N.R., primary, Decker, C., primary, Neumann, K., primary, Gosney, J.E., primary, Wissanji, H., primary, Chadi, S.A., primary, Alhabboubi, M., primary, Partridge, E., primary, Olszewski, M., primary, Chan, R., primary, Nadler, A., primary, Hameed, U., primary, Brotherhood, H., primary, Menezes, A.S., primary, MacDonald, B., primary, Rakovich, G., primary, Hilsden, R., primary, Merani, S., primary, Davis, P., primary, Davis, P.J.B., primary, Cools-Lartigue, J., primary, Ojah, J., primary, Julien, F., primary, Carter, D., primary, Pitt, D., primary, Banks, B.A., primary, Rudovics, A., primary, Ravichandran, P., primary, Anantha, R., primary, Aad, I., primary, Kholdebarin, R., primary, Aird, L.N.F., primary, Wong, S.L., primary, Payne, J.R.M., primary, Hallet, J., primary, Farries, L., primary, Raiche, I., primary, Botkin, C., primary, Morency, D., primary, Berger-Richardson, D., primary, Isa, A.D., primary, Dupuis, I, primary, Schweigert, M., primary, Koubi, S., primary, Ernjakovic, M., primary, Grant, K., primary, Carrott, P., primary, Stafford, T., primary, Malthaner, R., primary, Hanna, W.C., primary, Lee, L., primary, Markar, S., primary, Razzak, R., primary, Bharadwaj, S.C., primary, Ashrafi, A.S., primary, Ouellette, D., primary, Bottoni, D.A., primary, Knickle, C., primary, Coughlin, S., primary, Gazala, S., primary, Donahoe, L., primary, Walker, K., primary, Li, C., primary, Alnasser, S., primary, Zhuruk, A., primary, Hanouf, A., primary, Vanounou, T., primary, Karanicolas, P., primary, Aubin, J.-M., primary, Yeung, J.C., primary, Dumitra, S., primary, Simoneau, E., primary, Vanounou, T.T., primary, Howe, B., primary, Hawel, J., primary, Jang, J.-H., primary, Bertens, K., primary, Rekman, J.F., primary, Wei, A.C., primary, Ouellet, J.-F., primary, Covelli, A., primary, Maniar, R., primary, Sun, S., primary, Brackstone, M., primary, Boissonneault, R., primary, Kim, S.H.H., primary, Baliski, C., primary, Arnaout, A., primary, Wedman, D., primary, Nostedt, M., primary, Hebbard, P., primary, Shetty, S.J., primary, Dixon, M., primary, Kazazian, K., primary, Lemke, M., primary, Wells, B., primary, Musselman, R.P., primary, Zih, F. Si Wai, primary, Nassif, M., primary, Leon-Carlyle, M., primary, Krotneva, S., primary, Bradley, N.L., primary, Trabulsi, N., primary, Chin-Lenn, L., primary, Cheng, H., primary, Petrucci, A.M., primary, Sandhu, L., primary, Neville, A., primary, Yang, I., primary, Prabhu, K. Lobo, primary, Melich, G., primary, Knowles, S., primary, Borowiec, A.M., primary, Kolozsvari, N.O., primary, Tuttle, P., primary, VanHouwelingen, L., primary, Boulanger-Gobeil, C., primary, Chan, B.P., primary, Phang, P.T., primary, Goldstein, L.J., primary, Wen, C., primary, Lebrun, A., primary, Roy, M., additional, Villeneuve, S., additional, AlMuntashery, A., additional, Demyttenaere, S., additional, Christou, N., additional, Court, O., additional, Fayez, R., additional, Bonrath, E., additional, Hagen, J., additional, Okrainec, A., additional, Sullivan, P., additional, Grantcharov, T., additional, Sharma, A., additional, Karmali, S., additional, Birch, D.W., additional, Majumdar, S.R., additional, Wang, X., additional, Tuepah, R., additional, Klarenbach, S.W., additional, Sharma, A.M., additional, Padwal, R.J., additional, Smith, C., additional, Haggar, F., additional, Moloo, H., additional, Poulin, E.C., additional, Martel, G., additional, Yelle, J.-D., additional, Mamazza, J., additional, Jackson, T.D., additional, Penner, T., additional, Pitzul, K., additional, Urbach, D.R., additional, Biertho, L., additional, Hould, F.-S., additional, Lebel, S., additional, Lescelleur, O., additional, Marceau, S., additional, Marceau, P., additional, Biron, S., additional, Yusuf, S., additional, Pitzul, K.B., additional, Jackson, T., additional, Lindsay, D., additional, Smith, L., additional, Zevin, B., additional, Dedy, N., additional, Grantcharov, T.P., additional, Bonrath, E.M., additional, Aggarwal, R., additional, Cassin, S., additional, Crawford, S., additional, Khan, A., additional, Hawa, R., additional, Brar, B., additional, Raîche, I., additional, Dent, R., additional, Gill, R.S., additional, Ali, T., additional, Shi, X., additional, Whitlock, K.A., additional, Sarkhosh, K., additional, Turner, J.M., additional, Nation, P.N., additional, Wizzard, P., additional, Brubaker, P.L., additional, Gisalet, D.L., additional, Wales, P.W., additional, Tien, H., additional, Spencer, F., additional, Brenneman, F., additional, Kowal, J., additional, Wiseman, S.M., additional, Fraser, S.A., additional, Vedel, I., additional, Deban, M., additional, Holcroft, C., additional, Monette, M., additional, Monette, J., additional, Bergman, S., additional, Bell, C., additional, Stukel, T., additional, Mueller, T.F., additional, Lucykx, V.A., additional, Lukowski, C.M., additional, Compston, C.A., additional, Churchill, T.A., additional, Khadaroo, R.G., additional, Vogt, K., additional, Dubois, L., additional, Gray, D., additional, Ananth, A., additional, Tai, L.-H., additional, Lam, T., additional, Falls, T., additional, Souza, C., additional, Bell, J., additional, Auer, R., additional, Parry, N., additional, Leslie, K., additional, Alhabboubi, M., additional, St-Louis, E., additional, Deckelbaum, D., additional, Razek, T., additional, Feldman, L.S., additional, Khwaja, K., additional, Porter, G., additional, Johnson, P., additional, Boushey, R., additional, Raiche, I., additional, Schiller, D.E., additional, Eurich, D., additional, Sawyer, M.B., additional, Vergis, A., additional, Unger, B., additional, Hardy, K., additional, Andrew, C., additional, Gillman, L., additional, Park, J., additional, Prodger, J., additional, Kelly, W., additional, Kelly, S., additional, Prodger, D., additional, Ewara, E., additional, Martin, J., additional, Sarma, S., additional, Chu, M., additional, Schlachta, C., additional, Zaric, G., additional, Al-Ali, K., additional, Briggs, K., additional, George, R., additional, Murnaghan, M.L., additional, Leung, A., additional, Regehr, G., additional, Moulton, C.-A., additional, Mahmud, S., additional, Metcalfe, J., additional, McKay, A., additional, Hochman, D., additional, Burkle, F.M., additional, Redmond, A.D., additional, McQueen, K., additional, Desrosiers, E., additional, Gilbert, A., additional, Ott, M.C., additional, Sudarshan, M., additional, Jessula, S., additional, Alburakan, A., additional, Iqbal, S., additional, Aikins, C., additional, Roberts, N., additional, Cil, T., additional, Marshall, J., additional, Pederson, K., additional, Erichsen, S., additional, White, J., additional, Aarts, M.-A., additional, Victor, J.C., additional, Pearsall, E., additional, McLeod, R.S., additional, Penner, T.P., additional, Karimuddin, A., additional, Hall, C., additional, Bawan, S., additional, Malik, S., additional, Hayashi, A., additional, McAlister, C., additional, Zhang, N., additional, DesRosiers, Emilie, additional, Mills, A., additional, Crozier, M., additional, Lee, L., additional, Maxwell, J., additional, Partridge, E., additional, Chad, S., additional, Steigerwald, S., additional, Mapiour, D., additional, Roberts, D., additional, MacPherson, C., additional, Donahoe, L., additional, Mercer, D., additional, Hopman, W., additional, Latulippe, J.-F., additional, Knowles, S., additional, Moffat, B., additional, Switzer, N., additional, Tul, Y., additional, Widder, S., additional, Molinari, M., additional, Levy, A., additional, Bailey, J., additional, Hayden, J., additional, Benlolo, S., additional, Marcus, V., additional, Ferri, L., additional, Finley, R., additional, Anderson, D., additional, Gagné, J.-P., additional, Chan, S., additional, Wong, S., additional, Li, J., additional, Michael, A., additional, Choi, D., additional, Liu, E., additional, Hoogenes, J., additional, Dath, D., additional, Aubin, J.-M., additional, Mew, D., additional, McConnell, Y., additional, Classen, D., additional, Kanthan, S., additional, Croome, K.P., additional, Kovacs, M.J., additional, Lazo-Langner, A., additional, Hernandez-Alejandro, R., additional, Khoshgoo, N., additional, Iwasiow, B.M., additional, Keijzer, R., additional, Brown, C.J., additional, Isa, D., additional, Pace, D., additional, Primrose, M., additional, Hudson, D., additional, Lauzier, F., additional, Mailloux, O., additional, Trottier, V., additional, ARchambault, P., additional, Zarychanski, R., additional, Turgeon, A.F., additional, Hardy, P., additional, Muirhead, R.M., additional, Masters, J., additional, Poulin, H. Moloo. E.C., additional, Milbrandt, C., additional, Sideris, L., additional, Grenier-Vallée, P., additional, Dubé, P., additional, Kurashima, Y., additional, Kaneva, P., additional, Fried, G.M., additional, Vassiliou, M.C., additional, Kwan, A.H.-L., additional, Solymosi, N., additional, Rauh, N., additional, Dubecz, A., additional, Renz, M., additional, Ofner, D., additional, Stein, H.J., additional, Borgaonkar, M., additional, Crystal, P., additional, Easson, A., additional, Escallon, J., additional, Reedijk, M., additional, Leong, W.L., additional, McCready, D.R., additional, Clifton, J., additional, Mayo, J., additional, Noreau-Nguyen, M., additional, Mulder, D.S., additional, Ferri, L.E., additional, Markar, S., additional, Hong, J., additional, Low, D.E., additional, Maslow, A., additional, Davignon, K., additional, Ng, T., additional, Tan, L., additional, Aruranian, J., additional, Kosa, S., additional, Murphy, G., additional, Allison, F., additional, Moshonov, H., additional, Darling, G.E., additional, Waddell, T.K., additional, De Perrot, M., additional, Cypel, M., additional, Yasufuku, K., additional, Keshavjee, S., additional, Paul, N.S., additional, Pierre, A.F., additional, Darling, G., additional, Pedneault, C., additional, Low, D., additional, Roa, W., additional, Löbenberg, R., additional, McEwan, S., additional, Bédard, E.L., additional, Louie, B.E., additional, Farivar, A.S., additional, McHugh, S.P., additional, Aye, R.W., additional, Tan-Tam, C., additional, De Vera, M., additional, Bond, R.J., additional, Ong, S.R., additional, Johal, B., additional, Schellenberg, D., additional, Po, M., additional, Nissar, S., additional, Lund, C., additional, Ahmadi, S.Y., additional, Wakil, N., additional, Rakovich, G., additional, Beauchamps, G., additional, Preston, S., additional, Baker, C., additional, Campbell, G., additional, Malthaner, R.A., additional, Bethune, D., additional, Henteleff, H., additional, Johnston, M., additional, Buduhan, G., additional, Coughlin, H. 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Abou, additional, Jamal, M., additional, Chaudhury, P., additional, Zogopoulos, G., additional, Petrakos, P., additional, Tchervenkov, J., additional, Barkun, J., additional, Jamal, M.H., additional, Hassanain, M., additional, Salman, A., additional, Tran, T., additional, Metrakos, P., additional, Groeschl, R.T., additional, Geller, D.A., additional, Marsh, J.W., additional, Gamblin, T.C., additional, Kim, P.T.W., additional, Greig, P. D., additional, Gallinger, S., additional, Wei, A.C., additional, Fischer, S.E., additional, Cleary, S.P., additional, Vogt, K.N., additional, Gray, D.K., additional, Aubin, J.M., additional, Fairfull-Smith, J.J., additional, Devitt, K.S., additional, Ramjaun, A., additional, Gallingher, S., additional, Alabbad, S., additional, Constantinos, D., additional, Hassanein, M., additional, Paraskevas, S., additional, Tanyingoh, D., additional, Dixon, E., additional, Kaplan, G.G., additional, Myers, R.P., additional, Howard, T.J., additional, Sutherland, F.R., additional, Zyromski, N.J., additional, Ball, C.G., additional, Coburn, N., additional, Law, C.H., additional, Greig, P., additional, Steven, G., additional, Baxter, N., additional, Fitch, M., additional, Wright, F., additional, Hochman, D.J., additional, Wirtzfeld, D.A., additional, Yaffe, C.S., additional, Yip, B., additional, Silverman, R., additional, McConnell, Y.J., additional, Temple, W.J., additional, Mack, L.A., additional, Bathe, O.F., additional, Scott, L., additional, Vandenberg, T., additional, Perera, F., additional, Potvin, K., additional, Chambers, A., additional, Loungnarath, R., additional, DeBroux, É., additional, Lavertu, S., additional, Donath, D., additional, Ayoub, J.-P., additional, Tehfé, M., additional, Richard, C., additional, Cornacchi, S.D., additional, Heller, B., additional, Farrokhyar, F., additional, Babra, M., additional, Lovrics, P.J., additional, Liberto, C., additional, Ghosh, S., additional, McLean, R., additional, Schiller, D., additional, Dumitra, S., additional, Duplisea, J., additional, Wexler, S., additional, Seely, J., additional, Smylie, J., additional, Knight, K., additional, Robertson, S., additional, Watters, J., additional, Zhang, T., additional, Arneout, A., additional, Wirtzfeld, D., additional, Yun, L., additional, Rakovitch, E., additional, Warner, E., additional, McCready, D., additional, Hodgson, N., additional, Quan, M.L., additional, Natarajan, B., additional, Govindarajan, V., additional, Thomas, P., additional, Loggie, B.W., additional, Brar, S., additional, Mahar, A., additional, Law, C., additional, Wiebe, M., additional, Baxter, N.N., additional, Gagliardi, A.R., additional, Kennedy, E.D., additional, Zih, F., additional, Rosario, C., additional, Dennis, J., additional, Gingras, A.-C., additional, Swallow, C., additional, Ko, Y.-J., additional, Rowsell, C., additional, Law, C.H.L., additional, Saskin, R., additional, Quan, M.-L., additional, Xie, M., additional, McLaughlin, K., additional, Marginean, C., additional, Moyana, T.N., additional, Boushey, R.P., additional, Auer, R.C., additional, Razik, R., additional, Haase, E., additional, Mathieson, A., additional, Smith, A.J., additional, Swallow, C.J., additional, Barnes, A., additional, Scheer, A.S., additional, Sabri, E., additional, Auer, R.A.C., additional, Reidel, K., additional, Trabulsi, N., additional, Meterissian, S., additional, Tamblyn, R., additional, Mayo, N., additional, Meguerditchian, A.N., additional, Brown, J.A., additional, Hamm, J., additional, Phang, P.T., additional, Raval, M.J., additional, Taylor, B., additional, Meguerditchian, A., additional, Hamm, J.D., additional, Patakfalvi, L., additional, Nassif, M., additional, Turcotte, R., additional, Nichols, A., additional, Riedel, K.E., additional, Winslade, N.E., additional, Grégoire, J.-P., additional, Abrahamovicz, M., additional, Megueerditchian, A., additional, Pasieka, J., additional, McMillan, C., additional, Lipa, J., additional, Snell, L., additional, Tomlinson, G., additional, Liberman, A.S., additional, Charlebois, P., additional, Stein, B., additional, Capretti, G., additional, Power, A., additional, Augustin, B., additional, Gamsa, A., additional, Kim, D.-J., additional, Feldman, L., additional, Vu, L., additional, Gown, A., additional, Jones, S., additional, Wiseman, S., additional, Jeong, D. Hyoun, additional, Hur, H., additional, Baik, S. Hyuk, additional, Kim, N. Kyu, additional, Faria, J., additional, Min, B. Soh, additional, Lumb, K., additional, Colquhoun, P., additional, Schmocker, S., additional, Huang, H., additional, Krzyzanowska, M. K., additional, Brierley, J., additional, Milot, H., additional, Lebrun, A., additional, Drolet, S., additional, Bouchard, A., additional, Grégoire, R.C., additional, Vuong, T., additional, DeBroux, E., additional, Liberman, S., additional, Powell, R., additional, Fowler, A., additional, Martin, K., additional, Pereira, G., additional, Einarsdottir, K., additional, Gagné, J.P., additional, Thibault, C., additional, Bouchard, P., additional, Gomes, T., additional, Musselman, R.P., additional, Mamdani, M., additional, Al-Omran, M., additional, AlObeed, O., additional, Armstrong, J.B.P., additional, Fergusson, D.A., additional, Forster, A.J., additional, Gomes, Tara, additional, Chan, B.P., additional, Al-Obaid, O., additional, Lim, D. Ro, additional, Gordon, P.H., additional, Lo, A., additional, Pinsk, I., additional, Brown, C., additional, Raval, M., additional, Cheng, H., additional, Wong, C., additional, Johnston, N., additional, Stephen, W., additional, Lindsay, L., additional, Forbes, S., additional, and Parry, N.G., additional

Published
2012
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12. 2586

Author

Provencher, S., primary, Lavertu, S., additional, Jolicoeur, M., additional, Fortin, B., additional, Desroches, V., additional, and Donath, D., additional

Published
2006
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15. Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma

Author

Jolicoeur Marjory, Lavertu Sophie, Oehler Christoph, Provencher Sawyna, Fortin Bernard, and Donath David

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Purpose To evaluate quality of life (QOL) and outcome of patients with anal carcinoma treated with short split-course chemoradiation (CRT). Methods From 1991 to 2005, 58 patients with anal cancer were curatively treated with CRT. External beam radiotherapy (52 Gy/26 fractions) with elective groin irradiation (24 Gy) was applied in 2 series divided by a median gap of 12 days. Chemotherapy including fluorouracil and Mitomycin-C was delivered in two sequences. Long-term QOL was assessed using the site-specific EORTC QLQ-CR29 and the global QLQ-C30 questionnaires. Results Five-year local control, colostomy-free survival, and overall survival were 78%, 94% and 80%, respectively. The global QOL score according to the QLQ-C30 was good with 70 out of 100. The QLQ-CR29 questionnaire revealed that 77% of patients were mostly satisfied with their body image. Significant anal pain or fecal incontinence was infrequently reported. Skin toxicity grade 3 or 4 was present in 76% of patients and erectile dysfunction was reported in 100% of male patients. Conclusions Short split-course CRT for anal carcinoma seems to be associated with good local control, survival and long-term global QOL. However, it is also associated with severe acute skin toxicity and sexual dysfunction. Implementation of modern techniques such as intensity-modulated radiation therapy (IMRT) might be considered to reduce toxicity.

Published
2010
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17. OPAR: A Randomized Trial of Partial Breast Irradiation in Five Fractions Once Daily for Early Breast Cancer.

Author

Kim DH, Théberge V, Parpia S, Kong I, Provencher S, Yassa M, Perera F, Lavertu S, Rousseau P, Lee J, Karam I, Schneider K, Levine MN, and Whelan TJ

Abstract

Purpose: Previous studies suggest that external-beam partial breast irradiation (PBI) delivered twice a day can lead to increased adverse cosmesis (AC). The objective of our trial was to determine whether two regimens for PBI given once daily over 1 week resulted in acceptable AC to inform a phase III trial., Methods: Patients age ≥50 years with invasive breast cancer or ductal carcinoma in situ, ≤3 cm in size treated by lumpectomy with negative axillary nodes were randomly assigned to external-beam PBI of 30 Gy or 27.5 Gy, each given in five fractions once daily. The primary outcome was AC (fair or poor) by photographic assessment at 2 years. Secondary outcomes included AC assessed by nurse at 2 years, by patient self-assessment at 3 years, and late toxicity. On the basis of a 17% risk of AC with whole-breast irradiation, the upper bound of a two-sided 90% CI, 23% was set as the tolerance margin (OPAR, ClinicalTrials.gov identifier: NCT02637024)., Results: In total, 142 patients were randomly assigned to 30 Gy and 139 to 27.5 Gy. The median follow-up was 5 years. The mean age was 65 years, and the mean tumor size was 1.2 cm. Both schedules met acceptability criteria by photographic assessment (AC, 12.1% [90% CI, 8.2 to 17.6] for 30 Gy and 15.2% [90% CI, 10.8 to 21.1] for 27.5 Gy) and by nurse assessment. AC by patient self-assessment exceeded the 90% CI for the 30 Gy regimen. At 5 years, 16 (11.3%, 90% CI, 7.6 to 16.4) patients treated with 30 Gy and eight (5.8%, 90% CI, 3.3 to 9.9) patients treated with 27.5 Gy were observed to have grade 2 or more late toxicity., Conclusion: According to the study design, 30 Gy and 27.5 Gy resulted in acceptable cosmetic outcomes. In light of recent studies, a lower dose was chosen for the phase III trial.

Published
2024
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18. Prognostic Assessment of Interim F18-Fluorodeoxyglucose Positron Emission Tomography in Esophageal Cancer Treated With Chemoradiation With or Without Surgery.

Author

Lavertu S, Barkati M, Beaulieu S, Martin J, Campeau MP, Donath D, and Roberge D

Abstract

Purpose This study aimed to evaluate if the F18-fluorodeoxyglucose positron emission tomography (F18-FDG PET) response after two weeks of chemoradiation for locoregionally advanced esophageal cancer (staged Tumor (T) 3 and/or Nodes (N)+ Metastases (M) 0) was linked to the pathologic response for patients undergoing surgery, to disease-free survival (DFS) or overall survival (OS). Materials and Methods Between March 2006 and September 2017, 40 patients were prospectively enrolled in our study, gave written consent, and had PET scans performed before treatment and after two weeks of chemoradiation. One patient did not undergo his two-week PET without informing study coordinators and was excluded from analyses. Results The median age at diagnosis was 62 years. Seventy-two percent of patients had N+ disease. Median OS for the entire group was 24 months. Five-year overall survival was 17%. Survival curves for patients with no PET response, minor PET response, or good PET response overlapped and were not statistically different. For the 25 patients who underwent surgery, the positive predictive value (PPV) of the PET response relative to the pathologic response was 75% and the negative predictive value (NPV) was 62%. In study patients, the crude recurrence rate was 68% and there was no correlation between PET response and DFS. Conclusion In our study, interim PET response after two weeks of chemoradiation for locoregionally advanced esophageal cancer was not predictive of outcome or pathologic response. Based on our data and current literature, interim PET should not be used to alter treatment (whether to escalate neo-adjuvant treatment or omit surgery)., Competing Interests: The authors have declared financial relationships, which are detailed in the next section., (Copyright © 2022, Lavertu et al.)

Published
2022
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19. External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial.

Author

Whelan TJ, Julian JA, Berrang TS, Kim DH, Germain I, Nichol AM, Akra M, Lavertu S, Germain F, Fyles A, Trotter T, Perera FE, Balkwill S, Chafe S, McGowan T, Muanza T, Beckham WA, Chua BH, Gu CS, Levine MN, and Olivotto IA

Subjects
Aged, Australia, Breast Neoplasms surgery, Canada, Carcinoma in Situ pathology, Carcinoma in Situ surgery, Carcinoma, Ductal, Breast surgery, Female, Humans, Mastectomy, Segmental, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local prevention & control, New Zealand, Prognosis, Survival Rate, Brachytherapy methods, Breast Neoplasms radiotherapy, Carcinoma in Situ radiotherapy, Carcinoma, Ductal, Breast radiotherapy
Abstract

Background: Whole breast irradiation delivered once per day over 3-5 weeks after breast conserving surgery reduces local recurrence with good cosmetic results. Accelerated partial breast irradiation (APBI) delivered over 1 week to the tumour bed was developed to provide a more convenient treatment. In this trial, we investigated if external beam APBI was non-inferior to whole breast irradiation., Methods: We did this multicentre, randomised, non-inferiority trial in 33 cancer centres in Canada, Australia and New Zealand. Women aged 40 years or older with ductal carcinoma in situ or node-negative breast cancer treated by breast conserving surgery were randomly assigned (1:1) to receive either external beam APBI (38·5 Gy in ten fractions delivered twice per day over 5-8 days) or whole breast irradiation (42·5 Gy in 16 fractions once per day over 21 days, or 50 Gy in 25 fractions once per day over 35 days). Patients and clinicans were not masked to treatment assignment. The primary outcome was ipsilateral breast tumour recurrence (IBTR), analysed by intention to treat. The trial was designed on the basis of an expected 5 year IBTR rate of 1·5% in the whole breast irradiation group with 85% power to exclude a 1·5% increase in the APBI group; non-inferiority was shown if the upper limit of the two-sided 90% CI for the IBTR hazard ratio (HR) was less than 2·02. This trial is registered with ClinicalTrials.gov, NCT00282035., Findings: Between Feb 7, 2006, and July 15, 2011, we enrolled 2135 women. 1070 were randomly assigned to receive APBI and 1065 were assigned to receive whole breast irradiation. Six patients in the APBI group withdrew before treatment, four more did not receive radiotherapy, and 16 patients received whole breast irradiation. In the whole breast irradiation group, 16 patients withdrew, and two more did not receive radiotherapy. In the APBI group, a further 14 patients were lost to follow-up and nine patients withdrew during the follow-up period. In the whole breast irradiation group, 20 patients were lost to follow-up and 35 withdrew during follow-up. Median follow-up was 8·6 years (IQR 7·3-9·9). The 8-year cumulative rates of IBTR were 3·0% (95% CI 1·9-4·0) in the APBI group and 2·8% (1·8-3·9) in the whole breast irradiation group. The HR for APBI versus whole breast radiation was 1·27 (90% CI 0·84-1·91). Acute radiation toxicity (grade ≥2, within 3 months of radiotherapy start) occurred less frequently in patients treated with APBI (300 [28%] of 1070 patients) than whole breast irradiation (484 [45%] of 1065 patients, p<0·0001). Late radiation toxicity (grade ≥2, later than 3 months) was more common in patients treated with APBI (346 [32%] of 1070 patients) than whole breast irradiation (142 [13%] of 1065 patients; p<0·0001). Adverse cosmesis (defined as fair or poor) was more common in patients treated with APBI than in those treated by whole breast irradiation at 3 years (absolute difference, 11·3%, 95% CI 7·5-15·0), 5 years (16·5%, 12·5-20·4), and 7 years (17·7%, 12·9-22·3)., Interpretation: External beam APBI was non-inferior to whole breast irradiation in preventing IBTR. Although less acute toxicity was observed, the regimen used was associated with an increase in moderate late toxicity and adverse cosmesis, which might be related to the twice per day treatment. Other approaches, such as treatment once per day, might not adversely affect cosmesis and should be studied., Funding: Canadian Institutes for Health Research and Canadian Breast Cancer Research Alliance., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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20. In a Heartbeat: An Assessment of Dynamic Dose Variation to Cardiac Structures Using Dual Source Computed Tomography.

Author

Bahig H, de Guise J, Vu T, Blais D, Chartrand-Lefebvre C, Nguyen NT, Lavertu S, Guay JP, Bedwani S, and Roberge D

Subjects
Aged, Breast Neoplasms diagnostic imaging, Breath Holding, Female, Humans, Middle Aged, Prospective Studies, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Breast Neoplasms radiotherapy, Heart radiation effects, Tomography, X-Ray Computed methods
Abstract

Purpose: To assess radiation dose variation to the left anterior descending artery (LAD), left main coronary artery (LMCA), left ventricle (LV), and whole heart (WH) during the cardiac cycle using dual source computed tomography (DSCT)., Methods and Materials: The present prospective study included patients with left-side breast cancer planned to undergo tangential radiation therapy. An electrocardiogram-synchronized contrast-injected DSCT scan was obtained with the patient in the treatment position, in deep-inspiration breath-hold, using retrospective sequential acquisition. The WH, LV, LMCA, and proximal, middle, and distal LAD segments were contoured on each phase of the cardiac cycle. The maximum, minimum, and mean Hausdorff distance between each structure and the tangential fields was assessed in ventricular systole and diastole. Four-dimensional dose-volume histograms were used to compare the systolic and diastolic dosimetric data., Results: Ten patients were enrolled. The average maximum, minimum, and mean Hausdorff distance variation from systole to diastole was ≤4 mm for the LV and LMCA and ≤3 mm for the WH and LAD segments. WH maximum dose and volume receiving 5 Gy were decreased in systole compared with diastole (42.9 Gy versus 44.5 Gy, P = .03, and 21.7 cm 3 versus 27.7 cm 3 , P = .01), but the mean dose remained similar throughout the cycle. The maximum and mean dose to the distal LAD was 21.2 Gy versus 26.6 Gy (P = .005) and 8.6 Gy versus 13.2 Gy (P = .006) in systole versus diastole, respectively. The maximum and mean dose to the middle LAD was 18.4 Gy versus 25.1 Gy (P = .005) and 8.5 Gy versus 10.2 Gy in systole versus diastole (P = .005). The maximum dose to the LV was lower in systole than in diastole (21.5 Gy vs 26.7 Gy; P = .005)., Conclusions: In addition to deep-inspiration breath-hold, systolic irradiation is associated with a reduction in dose to the LAD, LV, and WH. In addition to its potential use in radiation planning for cardiac gating, DSCT imaging can be used to help define a planning organ at risk volume for clinically important cardiac substructures., (Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.)

Published
2018
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21. Predictors of adverse cosmetic outcome in the RAPID trial: an exploratory analysis.

Author

Peterson D, Truong PT, Parpia S, Olivotto IA, Berrang T, Kim DH, Kong I, Germain I, Nichol A, Akra M, Roy I, Reed M, Fyles A, Trotter T, Perera F, Balkwill S, Lavertu S, Elliott E, Julian JA, Levine MN, and Whelan TJ

Subjects
Age Factors, Aged, Breast Diseases complications, Breast Neoplasms nursing, Breast Neoplasms pathology, Carcinoma, Ductal, Breast nursing, Carcinoma, Ductal, Breast pathology, Female, Humans, Infections complications, Logistic Models, Middle Aged, Radiation Injuries complications, Radiation Injuries nursing, Radiation Injuries pathology, Radiotherapy methods, Radiotherapy Dosage, Radiotherapy, Conformal methods, Risk Factors, Seroma complications, Seroma pathology, Time Factors, Treatment Outcome, Tumor Burden, Breast radiation effects, Breast Neoplasms radiotherapy, Carcinoma, Ductal, Breast radiotherapy, Esthetics, Radiotherapy, Conformal adverse effects
Abstract

Purpose: To evaluate factors associated with adverse cosmesis outcome in breast cancer patients randomized to accelerated partial breast irradiation (APBI) using 3-dimensional conformal radiation therapy or whole-breast irradiation in the RAPID (Randomized Trial of Accelerated Partial Breast Irradiation) trial., Methods and Materials: Subjects were trial participants with nurse-assessed global cosmetic scores at baseline and at 3 years. Adverse cosmesis was defined as a score of fair or poor. Cosmetic deterioration was defined as any adverse change in score from baseline to 3 years. The analysis is based on data from the previously reported interim analysis. Logistic regression models were used to assess the association of risk factors for these outcomes among all patients and those treated with APBI only., Results: Clinicopathologic characteristics were similar between subjects randomized to APBI (n=569) or whole-breast irradiation (n=539). For all subjects, factors associated with adverse cosmesis at 3 years were older age, central/inner tumor location, breast infection, smoking, seroma volume, breast volume, and use of APBI; factors associated with cosmetic deterioration were smoking, seroma volume, and use of APBI (P<.05). For APBI subjects, tumor location, smoking, age, and seroma volume were associated with adverse cosmesis (P<.05), and smoking was associated with cosmetic deterioration (P=.02). An independent association between the V95/whole-breast volume ratio and adverse cosmesis (P=.28) or cosmetic deterioration (P=.07) was not detected. On further exploration a V95/whole-breast volume ratio <0.15 was associated with a lower risk of cosmetic deterioration (p=.04), but this accounted for only 11% of patients., Conclusion: In the RAPID trial, a number of patient tumor and treatment-related factors, including the use of APBI, were associated with adverse cosmesis and cosmetic deterioration. For patients treated with APBI alone, the high-dose treatment volume was not independently associated with an adverse cosmetic outcome, and a useful clinical threshold could not be identified., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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22. Canadian Surgery Forum.

Author

Fayez R, Roy M, Villeneuve S, AlMuntashery A, Demyttenaere S, Christou N, Court O, AlMuntashery A, Fayez R, Demyttenaere S, Christou N, Court O, Bodie G, Bonrath E, Hagen J, Okrainec A, Sullivan P, Grantcharov T, Almamar A, Sharma A, Karmali S, Birch DW, Gill RS, Majumdar SR, Wang X, Tuepah R, Klarenbach SW, Birch DW, Karmali S, Sharma AM, Padwal RJ, Raîche I, Smith C, Haggar F, Moloo H, Poulin EC, Martel G, Yelle JD, Mamazza J, Mueller CL, Jackson TD, Penner T, Pitzul K, Urbach DR, Okrainec A, AlMuntashery A, Villeneuve S, Roy M, Fayez R, Demyttenaere S, Christou N, Court O, Fayez R, Roy M, Villeneuve S, AlMuntashery A, Demyttenaere S, Christou N, Court O, AlMuntashery A, Fayez R, Demyttenaere S, Court O, Christou N, Moustarah F, Biertho L, Hould FS, Lebel S, Lescelleur O, Marceau S, Marceau P, Biron S, Khokhotva M, Grantcharov T, Anvari M, Sharma A, Yusuf S, Kwong J, Okrainec A, Pitzul KB, Urbach DR, Jackson T, Elkassem S, Lindsay D, Sullivan P, Smith L, Bonrath E, Zevin B, Dedy N, Grantcharov TP, Zevin B, Bonrath EM, Aggarwal R, Grantcharov T, Sockalingam S, Cassin S, Crawford S, Pitzul K, Khan A, Hawa R, Jackson T, Okrainec A, Smith C, Brar B, Mamazza J, Raîche I, Yelle JD, Haggar F, Moloo H, Smith C, Brar B, Haggar F, Dent R, Mamazza J, Raîche I, Moloo H, Whitlock KA, Gill RS, Ali T, Shi X, Birch DW, Karmali S, Gill RS, Whitlock KA, Shi X, Sarkhosh K, Birch DW, Karmali S, Suri M, Turner JM, Nation PN, Wizzard P, Brubaker PL, Gisalet DL, Wales PW, Palter VN, Grantcharov TP, Wakeam E, Tien H, Spencer F, Brenneman F, Khan RSA, Kowal J, Wiseman SM, Martelli V, Fraser SA, Vedel I, Deban M, Holcroft C, Monette M, Monette J, Bergman S, Malik A, Bell C, Stukel T, Urbach DR, Young PY, Mueller TF, Lucykx VA, Lukowski CM, Compston CA, Churchill TA, Khadaroo RG, Daigle C, Grantcharov T, McCreery G, Vogt K, Dubois L, Gray D, Seth R, Ananth A, Tai LH, Lam T, Falls T, Souza C, Bell J, Auer R, Paskar D, Crawford S, Parry N, Leslie K, Sudarshan M, Alhabboubi M, St-Louis E, 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Keijzer R, Aird LNF, Brown CJ, Wong SL, Isa D, Pace D, Payne JRM, Widder S, Tul Y, Primrose M, Hudson D, Khadaroo RG, Hallet J, Lauzier F, Mailloux O, Trottier V, ARchambault P, Zarychanski R, Turgeon AF, Mailloux O, Farries L, Hardy P, Muirhead RM, Raiche I, Masters J, Haggar F, Poulin HMEC, Martel G, Mamazza J, Botkin C, Milbrandt C, Keijzer R, Morency D, Sideris L, Grenier-Vallée P, Latulippe JF, Dubé P, Berger-Richardson D, Kurashima Y, Kaneva P, Feldman LS, Fried GM, Vassiliou MC, Isa AD, Kwan AH, Dupuis I, Fraser SA, Schweigert M, Solymosi N, Rauh N, Dubecz A, Renz M, Ofner D, Stein HJ, Koubi S, Borgaonkar M, Ernjakovic M, Crystal P, Easson A, Escallon J, Reedijk M, Cil T, Leong WL, McCready DR, Grant K, Clifton J, Mayo J, Finley R, Cools-Lartigue J, Noreau-Nguyen M, Mulder DS, Ferri LE, Carrott P, Markar S, Hong J, Low DE, Stafford T, Maslow A, Davignon K, Ng T, Malthaner R, Tan L, Aruranian J, Kosa S, Sudarshan M, Ferri LE, Hanna WC, Murphy G, Allison F, Moshonov H, Darling GE, Waddell TK, De Perrot M, Cypel M, Yasufuku K, Keshavjee S, Paul NS, Pierre AF, Lee L, Darling G, Pedneault C, Marcus V, Mulder DS, Ferri LE, Markar S, Low D, Razzak R, Roa W, Löbenberg R, McEwan S, Bédard EL, Bharadwaj SC, Louie BE, Farivar AS, McHugh SP, Aye RW, Ashrafi AS, Tan-Tam C, De Vera M, Bond RJ, Ong SR, Johal B, Schellenberg D, Po M, Nissar S, Lund C, Ahmadi SY, Ouellette D, Wakil N, Rakovich G, Beauchamps G, Markar S, Preston S, Baker C, Low D, Bottoni DA, Campbell G, Malthaner RA, Knickle C, Bethune D, Henteleff H, Johnston M, Buduhan G, Coughlin S, Coughlin HE, Roth L, Bhandari M, Malthaner R, Gazala S, Johnson J, Kutsogiannis J, Bédard E, Gazala S, Rammohan K, Stewart K, Bédard E, Donahoe L, Buduhan G, Walker K, Gruchy J, Xu Z, Buduhan G, Li C, Ferri LE, Mulder DS, Ncuti A, Neville A, Kaneva P, Watson D, Vassiliou M, Carli F, Feldman LS, Alnasser S, Av R, Mayrand S, Franco E, Ferri LE, Schweigert M, Dubecz A, Renz M, Stadlhuber RJ, Ofner D, Stein HJ, Schweigert M, Renz M, Dubecz A, Solymosi N, Thumfart L, Ofner D, Stein HJ, Zhuruk A, Croome K, Leeper R, Hernandez R, Hanouf A, Livingstone S, Sapp J, Woodhall D, Alwayn I, Vanounou T, Bergman S, Karanicolas P, Lam-McCulloch J, Balaa F, Jayaraman S, Quan D, Wei A, Guyatt G, Aubin JM, Rekman JF, Fairfull-Smith RJ, Mimeault R, Balaa FK, Martel G, Yeung JC, Boehnert MS, Bazerbachi F, Knaak JM, Selzner N, McGilvray ID, Rotstein OD, Adeyi OA, Levy GA, Keshavjee S, Grant DR, Selzner M, Dumitra S, Khalil JA, Jamal M, Chaudhury P, Zogopoulos G, Petrakos P, Tchervenkov J, Barkun J, Simoneau E, Jamal MH, Hassanain M, Chaudhury P, Wong S, Salman A, Tran T, Metrakos P, Vanounou TT, Groeschl RT, Geller DA, Marsh JW, Gamblin TC, Howe B, Croome K, Hawel J, Croome K, Quan D, Hernandez R, Jang JH, Kim PTW, Greig PD, Gallinger S, Moulton CA, Wei AC, Fischer SE, Cleary SP, Bertens K, Vogt KN, Hernandez-Alejandro R, Gray DK, Rekman JF, Aubin JM, Fairfull-Smith JJ, Mimeault R, Balaa FK, Martel G, Wei AC, Devitt KS, Ramjaun A, Gallingher S, Dumitra S, Alabbad S, Constantinos D, Hassanein M, Barkun J, Metrakos P, Paraskevas S, Chaudhury P, Tchervenkov J, Koubi S, Borgaonkar M, Ouellet JF, Tanyingoh D, Dixon E, Kaplan GG, Myers RP, Howard TJ, Sutherland FR, Zyromski NJ, Ball CG, Wei AC, Coburn N, Moulton CA, Cleary SP, Law CH, Greig P, Steven G, Covelli A, Baxter N, Fitch M, Wright F, Maniar R, Hochman DJ, Wirtzfeld DA, McKay A, Yaffe CS, Yip B, Silverman R, Park J, Sun S, McConnell YJ, Temple WJ, Mack LA, Davis VW, Schiller DE, Bathe OF, Sawyer MB, Brackstone M, Scott L, Vandenberg T, Perera F, Potvin K, Chambers A, Boissonneault R, Loungnarath R, DeBroux É, Lavertu S, Donath D, Ayoub JP, Tehfé M, Richard C, Kim SHH, Cornacchi SD, Heller B, Farrokhyar F, Babra M, Lovrics PJ, Baliski C, Liberto C, Gazala S, Ghosh S, McLean R, Schiller D, Hameed U, Jackson TD, Okrainec A, Penner TP, Urbach DR, Sudarshan M, Dumitra S, Duplisea J, Wexler S, Arnaout A, Seely J, Smylie J, Knight K, Robertson S, Watters J, Wedman D, Zhang T, Arneout A, Nostedt M, Hochman D, Wirtzfeld D, McKay A, Yip B, Yaffe CS, Silverman R, Park J, Hebbard P, Baxter N, Yun L, Rakovitch E, Wright F, Warner E, McCready D, Hodgson N, Quan ML, Shetty SJ, Natarajan B, Govindarajan V, Thomas P, Loggie BW, Dixon M, Brar S, Mahar A, Law C, Coburn N, Wei AC, Devitt KS, Wiebe M, Bathe OF, McLeod RS, Baxter NN, Gagliardi AR, Kennedy ED, Urbach DR, Dixon M, Brar S, Mahar A, Law C, Coburn N, Kazazian K, Zih F, Rosario C, Dennis J, Gingras AC, Swallow C, Lemke M, Ko YJ, Rowsell C, Law CHL, Wells B, Saskin R, Quan ML, Musselman RP, Xie M, McLaughlin K, Marginean C, Moyana TN, Moloo H, Boushey RP, Auer RC, Zih FSW, Razik R, Haase E, Mathieson A, Smith AJ, Swallow CJ, Menezes AS, Barnes A, Scheer AS, Moloo H, Boushey RP, Sabri E, Auer RAC, Nassif M, Reidel K, Trabulsi N, Meterissian S, Tamblyn R, Mayo N, Meguerditchian AN, Leon-Carlyle M, Brown JA, Hamm J, Phang PT, Raval MJ, Brown CJ, Wei AC, Devitt KS, Wiebe M, Bathe OF, McLeod RS, Taylor B, Urbach DR, Krotneva S, Reidel K, Mayo N, Tamblyn R, Meguerditchian A, Bradley NL, Hamm JD, Wiseman SM, Trabulsi N, Patakfalvi L, Nassif M, Turcotte R, Nichols A, Meguerditchian A, Trabulsi N, Riedel KE, Winslade NE, Grégoire JP, Meterissian S, Abrahamovicz M, Megueerditchian A, Chin-Lenn L, Pasieka J, Cheng H, McMillan C, Lipa J, Snell L, Petrucci AM, Sudarshan M, Dumitra S, Duplisea J, Wexler S, Meterissian S, Sandhu L, Tomlinson G, Kennedy ED, Wei A, Baxter NN, Urbach DR, Neville A, Liberman AS, Charlebois P, Stein B, Ncuti A, Vassiliou MC, Fried GM, Feldman LS, Lee L, Capretti G, Power A, Liberman AS, Charlebois P, Stein B, Kaneva P, Carli F, Fried GM, Feldman LS, Li C, Carli F, Charlebois P, Stein B, Liberman AS, Kaneva P, Augustin B, Gamsa A, Kim DJ, Vassiliou M, Feldman L, Yang I, Boushey R, Moloo H, Prabhu KL, Vu L, Chan S, Phang PT, Gown A, Jones S, Wiseman S, Melich G, Jeong DH, Hur H, Baik SH, Kim NK, Faria J, Min BS, Knowles S, Lumb K, Colquhoun P, Richardson D, Porter G, Johnson P, Borowiec AM, Baxter NN, Schmocker S, Huang H, Victor JC, Krzyzanowska MK, Brierley J, McLeod RS, Kennedy ED, Hallet J, Milot H, Desrosiers E, Lebrun A, Drolet S, Bouchard A, Grégoire RC, Boissonneault R, Vuong T, Loungnarath R, DeBroux E, Liberman AS, Charlebois P, Stein B, Richard C, Kolozsvari NO, Capretti G, Kaneva P, Neville A, Carli F, Liberman S, Charlebois P, Stein B, Vassiliou MC, Fried GM, Feldman LS, Hallet J, Milot H, Drolet S, Bouchard A, Grégoire RC, Tuttle P, Powell R, Fowler A, Mathieson A, VanHouwelingen L, Martin K, Vogt K, Ott MC, Haggar F, Pereira G, Einarsdottir K, Moloo H, Boushey R, Mamazza J, Boulanger-Gobeil C, Bouchard A, Gagné JP, Grégoire RC, Thibault C, Bouchard P, Chan BP, Gomes T, Musselman RP, Auer RC, Moloo H, Mamdani M, Al-Omran M, Boushey RP, AlObeed O, Chan BP, Armstrong JBP, Fergusson DA, Forster AJ, Boushey RP, Richardson D, Porter G, Johnson P, Musselman RP, Gomes T, Chan BP, Auer RC, Moloo H, Mamdani M, Al-Omran M, Al-Obaid O, Boushey RP, Melich G, Lim DR, Min BS, Baik SH, Gordon PH, Kim NK, Phang PT, Lo A, Pinsk I, Brown C, Raval M, Goldstein LJ, Cheng H, Wen C, Wong C, Johnston N, Farrokhyar F, Stephen W, Kelly S, Lindsay L, Forbes S, Lebrun A, Bouchard A, Chadi SA, Parry NG, Leslie K, and Ott MC

Published
2012
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23. Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma.

Author

Provencher S, Oehler C, Lavertu S, Jolicoeur M, Fortin B, and Donath D

Subjects
Adult, Aged, Aged, 80 and over, Anus Neoplasms pathology, Carcinoma, Squamous Cell pathology, Combined Modality Therapy, Female, Fluorouracil administration & dosage, Follow-Up Studies, Humans, Male, Middle Aged, Mitomycin administration & dosage, Retrospective Studies, Survival Rate, Time Factors, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Anus Neoplasms drug therapy, Anus Neoplasms radiotherapy, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell radiotherapy, Quality of Life, Radiotherapy Dosage
Abstract

Purpose: To evaluate quality of life (QOL) and outcome of patients with anal carcinoma treated with short split-course chemoradiation (CRT)., Methods: From 1991 to 2005, 58 patients with anal cancer were curatively treated with CRT. External beam radiotherapy (52 Gy/26 fractions) with elective groin irradiation (24 Gy) was applied in 2 series divided by a median gap of 12 days. Chemotherapy including fluorouracil and Mitomycin-C was delivered in two sequences. Long-term QOL was assessed using the site-specific EORTC QLQ-CR29 and the global QLQ-C30 questionnaires., Results: Five-year local control, colostomy-free survival, and overall survival were 78%, 94% and 80%, respectively. The global QOL score according to the QLQ-C30 was good with 70 out of 100. The QLQ-CR29 questionnaire revealed that 77% of patients were mostly satisfied with their body image. Significant anal pain or fecal incontinence was infrequently reported. Skin toxicity grade 3 or 4 was present in 76% of patients and erectile dysfunction was reported in 100% of male patients., Conclusions: Short split-course CRT for anal carcinoma seems to be associated with good local control, survival and long-term global QOL. However, it is also associated with severe acute skin toxicity and sexual dysfunction. Implementation of modern techniques such as intensity-modulated radiation therapy (IMRT) might be considered to reduce toxicity.

Published
2010
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24. Endocavitary radiation therapy for rectal adenocarcinoma: 10-year results.

Author

Lavertu S, Schild SE, Gunderson LL, Haddock MG, and Martenson JA

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Proctoscopes, Prognosis, Survival Analysis, Treatment Outcome, Adenocarcinoma radiotherapy, Brachytherapy, Rectal Neoplasms radiotherapy
Abstract

Local control, survival, and toxicity in patients treated with endocavitary radiation therapy for rectal cancer were evaluated. Thirty-five patients received a total of 20 to 155 Gy in 1 to 5 fractions with 50 kV x-rays through a treatment proctoscope. Twenty-nine of the 35 patients were treated with curative intent. Median follow-up was 102 months. Local control was achieved in 23 of the 29 patients treated curatively and in 3 of the 6 treated palliatively. Local control for patients treated curatively was 76% at 10 years. No local failures occurred after 21 months. For patients treated curatively, survival was 65% at 5 years and 42% at 10 years. Toxicity within 90 days after treatment was observed in 77% of the patients. Toxicity occurring more than 90 days after treatment was observed in 80%, but only 1 patient needed a colostomy, which was for a perforation after the biopsy of a benign ulcer. In conclusion, radiation therapy resulted in a local control rate of 76% at 10 years in curatively treated patients. Although most patients experience toxicity from this treatment, loss of sphincter function is rare.

Published
2003
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25. Local failure is responsible for the decrease in survival for patients with breast cancer treated with conservative surgery and postoperative radiotherapy.

Author

Fortin A, Larochelle M, Laverdière J, Lavertu S, and Tremblay D

Subjects
Actuarial Analysis, Adult, Aged, Breast Neoplasms radiotherapy, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Mastectomy, Segmental, Middle Aged, Multivariate Analysis, Retrospective Studies, Risk Factors, Survival Rate, Treatment Failure, Breast Neoplasms mortality, Breast Neoplasms therapy
Abstract

Purpose: The aim of the present study was to evaluate the role of local failure (LF) in the survival of patients treated with lumpectomy and postoperative radiotherapy and to investigate whether LF is not only a marker for distant metastasis (DM) but also a cause., Methods: Charts of patients treated with breast conservative surgery between 1969 and 1991 were reviewed retrospectively. There were 2,030 patients available for analysis. The median duration of follow-up was 6 years. A Cox regression multivariate analysis was performed using LF as a time-dependent covariate., Results: Local control (LC) was 87% at 10 years. Local failure led to poorer survival at 10 years than local control (55% v 75%, P < .00). In a Cox model, local failure was a powerful predictor of mortality. The relative risk associated with LF was 3.6 for mortality and 5.1 for DM (P < .00). In patients with LF, the rate of DM peaked at 5 to 6 years, whereas it peaked at 2 years for patients with LC. The mean time between surgery and DM was 1,050 days for patients without LF and 1,650 days for patients with LF (P < .00)., Conclusion: Our results show that local failure is associated with an increase in mortality. The difference in the time distribution of distant metastasis for LF and LC could imply distinct mechanisms of dissemination. Local failure should be considered not only as a marker of occult circulating distant metastases but also as a source for new distant metastases and subsequent mortality.

Published
1999
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