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6. Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis

Author

Boucher, Sophie, Tai, Fabienne Wong Jun, Delmaghani, Sedigheh, Lelli, Andrea, Singh-Estivalet, Amrit, Dupont, Typhaine, Niasme-Grare, Magali, Michel, Vincent, Wolff, Nicolas, Bahloul, Amel, Bouyacoub, Yosra, Bouccara, Didier, Fraysse, Bernard, Deguine, Olivier, Collet, Lionel, Thai-Van, Hung, Ionescu, Eugen, Kemeny, Jean-Louis, Giraudet, Fabrice, Lavieille, Jean-Pierre, Devèze, Arnaud, Roudevitch-Pujol, Anne-Laure, Vincent, Christophe, Renard, Christian, Franco-Vidal, Valérie, Thibult-Apt, Claire, Darrouzet, Vincent, Bizaguett, Eric, Coez, Arnaud, Aschard, Hugues, Michalski, Nicolas, Lefevre, Gaëlle M., Aubois, Anne, Avan, Paul, Bonnet, Crystel, and Petit, Christine

Published
2020

14. Paralysies faciales post-traumatiques

Author

Darrouzet, Vincent, primary, Barreau, Xavier, additional, Lavieille, Jean-Pierre, additional, Montava, Marion, additional, de Andrade, Alvaro Muiños, additional, Plantier, Diogo, additional, Lahlou, Ghizlène, additional, Tankéré, Frédéric, additional, Vincent, Christophe, additional, Ayache, Denis, additional, and de Monès del Pujol, Erwan, additional

Published
2020
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15. Liste des collaborateurs

Author

Ayache, Denis, primary, Barbut, Jonathan, additional, Barreau, Xavier, additional, Baujat, Bertrand, additional, Bazin, Arnaud, additional, Bernardeschi, Daniele, additional, Bricaire, François, additional, Charpiot, Anne, additional, Chays, André, additional, Cornu, Nicolas, additional, Darrouzet, Vincent, additional, Deguine, Olivier, additional, Denoix, Luna, additional, Devic, Perrine, additional, Disant, François, additional, Drouillard, Mylène, additional, Dubernard, Xavier, additional, Elmaleh-Bergès, Monique, additional, Fieux, Maxime, additional, Foirest, Claire, additional, Franco-Vidal, Valérie, additional, Gallois, Yohan, additional, Gatignol, Peggy, additional, Guevara, Nicolas, additional, Guichard, Jean-Pierre, additional, Herman, Philippe, additional, Hervochon, Rémi, additional, Kania, Romain, additional, Kleiber, Jean-Charles, additional, Kolb, Frédéric, additional, Lahlou, Ghizlène, additional, Lamas, Georges, additional, Lannadère, Élodie, additional, Lavieille, Jean-Pierre, additional, Mamelle, Élisabeth, additional, Marques, Cindy, additional, Molinier-Blossier, Sandrine, additional, de Monès del Pujol, Erwan, additional, Montava, Marion, additional, de Andrade, Alvaro Muiños, additional, Pasche, Philippe, additional, Picard, Diane, additional, Plantier, Diogo, additional, Qassemyar, Quentin, additional, Raffaelli, Charles, additional, Amédée Roch, Jean, additional, Saadoun, David, additional, Tankéré, Frédéric, additional, Tringali, Stéphane, additional, Trunet, Stéphanie, additional, Van Den Abbeele, Thierry, additional, Veillon, Francis, additional, Verillaud, Benjamin, additional, Vertu-Ciolino, Delphine, additional, Vincent, Christophe, additional, and Willer, Jean-Claude, additional

Published
2020
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26. Pourquoi un clic sonne comme un clic ? Et en quoi l’implant cochléaire peut nous aider à répondre à cette question

Author

Macherey, Olivier, Sodan, Ana, Meunier, Sabine, Péan, Vincent, Lavieille, Jean-Pierre, Roman, Stéphane, Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord [CHU - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Société Française d'Acoustique, and Laboratoire de Mécanique et d'Acoustique

Subjects
[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

Un clic est physiquement le son le plus court que nous puissions entendre et il est également perçu comme tel. Cependant, sa représentation neurale est beaucoup plus diffuse. En effet, le filtrage réalisé par la cochlée induit des délais entre les réponses des fibres du nerf auditif, les fibres apicales (codant pour les basses fréquences) pouvant être excitées jusqu’à 10 ou 15 millisecondes plus tardivement que les fibres basales (codant pour les hautes fréquences). Dau et al. (2000) ont montré qu’il était possible de construire un stimulus de type « chirp » contrecarrant les délais cochléaires. Ils ont montré par des mesures électrophysiologiques que ces chirps engendraient plus de synchronie entre les réponses neurales. Paradoxalement, ces chirps sont cependant toujours perçues comme ayant une durée plus longue qu’un clic. Deux explications ont été proposées pour ce paradoxe. La première est périphérique et liée aux propriétés de résonance de la membrane basilaire. La deuxième est centrale et propose qu’un mécanisme compense ces délais, rendant notre perception cohérente avec le monde physique. L’implant cochléaire constitue un modèle intéressant pour séparer ces deux hypothèses car il court-circuite le filtrage cochléaire. Huit porteurs d’implant cochléaire MedEL ont pris part à une série d’expériences perceptives et EEG ou nous leur présentions des chirps électriques consistant en des séquences d’impulsions électriques balayant leur faisceau d’électrodes de l’apex à la base (A-B) ou de la base à l’apex (B-A). Nos expériences montrent que des chirps B-A, imitant les délais cochléaires naturels, sont perçus comme plus courts et produisent des réponses corticales d’amplitude plus faible que les chirps A-B. Ces données suggèrent l’existence d’un mécanisme central cortical compensant les délais initiés à la périphérie.

Published
2022

27. Place of Tubomanometry in Patulous Eustachian Tube Diagnosis.

Author

Ros, Laetitia, Gargula, Stéphane, Montava, Marion, Michel, Justin, Radulesco, Thomas, and Lavieille, Jean‐Pierre

Abstract

Objective: The aim of our study was to describe the diagnostic performances of tubomanometry (TMM) and to determine tubomanometric parameter thresholds for the diagnosis of patulous eustachian tube (PET). Study Design: We performed a retrospective, monocentric study, including patients treated for PET vs control group. Setting: This study was performed at the Otolaryngology Department of a tertiary‐care hospital in the south of France. Methods: We collected epidemiologic and clinical data, as well as adjusted opening latency index ("R"‐index), rhinopharyngeal pressure threshold of tubal opening (Po), and velar contraction index (IVC) on TMM. Receiver operating characteristic (ROC) curves were used for determination of R index and Po thresholds. Results: Twenty‐one patients (26 patulous ears) and 14 controls (24 normal ears) were included. The R index values and Po values were significantly lower in the PET group vs controls (0.46 vs 0.80, respectively; P <.05 for R index and 13.89 vs 26.42 mbar, respectively; P <.05 for Po). No significant difference was reported between the 2 groups on IVC measurement (P =.784). After ROC curve analysis, R index was the most discriminating factor to classify PET patients with 89% specificity and 76% sensitivity with a threshold ≤0.6. Po value ≤10 mbar could support this diagnosis with more than 83% specificity. Conclusion: TMM is a reliable noninvasive method for positive diagnosis of PET. TMM could provide an accurate positive PET diagnosis and an objective evaluation for PET management. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Status of rehabilitation of the dizzy patient in France: focus on vestibular physiotherapy.

Author

Xavier, Frédéric, Chouin, Emmanuelle, Montava, Marion, Tighilet, Brahim, Lavieille, Jean-Pierre, and Chabbert, Christian

Subjects
DIZZINESS, PHYSICAL therapy, VESTIBULAR apparatus diseases, CONTINUING education, SURVEYS, QUESTIONNAIRES, DATA analysis software
Abstract

This study was carried out within the framework of a research on the non-medicinal managment of the dizzy patient. In order to carry out an inventory of vestibular rehabilitation practices in France, we conducted this research among practitioners recognized in this exercise. We conducted a survey using a thoretical questionnaire submitted to the whole community of french vestibular physiotherapists. We benefited from a statistically signifiant recruitment of this population and we were able to perform a statistical treatment of the data in order to answer questions concerning the current practice of vestibular rehabilitation. We observed autonomous therapeutic behaviours and the development of the practices of French vestibular physiotherapist which can be considered like a 'clinician of the vertigo re-education'. Continuing education nevertheless remains heterogeneous, and a national diploma resulting from standardised and adapted teaching does not sanction vestibular rehabilitation. This study is a 'snapshot' of the vestibular physiotherapist profession in France in 2019. It reveals a population of dynamic practitioners questioning their action in terms of health and their role regarding their prescribers, colleagues and other paramedical professions (osteopaths, orthoptists and psychomotricians). [ABSTRACT FROM AUTHOR]

Published
2023
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37. Is minor surgery safe during the COVID-19 pandemic? A multi-disciplinary study

Author

Baboudjian, Michael, primary, Mhatli, Mehdi, additional, Bourouina, Adel, additional, Gondran-Tellier, Bastien, additional, Anastay, Vassili, additional, Perez, Lea, additional, Proye, Pauline, additional, Lavieille, Jean-Pierre, additional, Duchateau, Fanny, additional, Agostini, Aubert, additional, Wazne, Yann, additional, Sebag, Frederic, additional, Foletti, Jean-Marc, additional, Chossegros, Cyrille, additional, Raoult, Didier, additional, Touati, Julian, additional, Chagnaud, Christophe, additional, Michel, Justin, additional, Bertrand, Baptiste, additional, Giovanni, Antoine, additional, Radulesco, Thomas, additional, Sartor, Catherine, additional, Fournier, Pierre-Edouard, additional, and Lechevallier, Eric, additional

Published
2021
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39. Evaluating the use of Bunched-up pulses for objective determination of thresholds in Cochlear Implants Users

Author

Sodan, Ana, Meunier, Sabine, Péan, Vincent, Roman, Stéphane, Montava, Marion, Lavieille, Jean-Pierre, Macherey, Olivier, Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Sons, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Centre de Ressources Technologiques, Innotech, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de neurophysiopathologie (INP), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Hôpital Nord [CHU - APHM], Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Cochlear Implant, Objective Measures, Threshold, otorhinolaryngologic diseases, Temporal integration, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

International audience; Fitting a cochlear implant (CI) to a patient requires to determine detection thresholds and comfortably loud levels for all CI electrodes. This process is difficult to achieve behaviorally in infants, urging researchers to find alternative objective methods, such as electrically-evoked auditory brainstem responses (eABRs). Although eABR thresholds for low-rate pulse trains correlate strongly with behavioral thresholds measured at the same rate, this correlation is much weaker with behavioral thresholds measured at higher rates, such as used in clinical CIs. This weak correlation is probably due to the fact that short-time constant temporal processes influence detection thresholds. We recently introduced bunched-up-pulses (BUPS) as an alternative stimulus to measure eABRs in CI subjects in order to capture the contribution of some of these temporal processes. BUPS stimuli consist of groups of n ?bunched- up? pulses repeated at a low frame rate. Here we evaluate the hypothesis that eABR thresholds obtained for a BUPS stimulus with n=12 could be used as a predictor of clinical thresholds. 15 MED-EL cochlear implant recipients were tested on two electrodes (apical and medial one). For each electrode, behavioral thresholds were measured for the clinical stimulus, and for BUPS stimuli with n=1 and n=12. Results show that eABR thresholds are significantly closer to clinical psychophysical thresholds for n=12 compared to n=1. This suggests that eABRs to BUPS capture some aspects of short-time temporal integration. Across-subject correlations between eABR thresholds for BUPS and clinical thresholds were also significant for both electrodes and for both types of stimuli (n=1 and n=12). However, the correlation was not stronger for n=12. This suggests that additional temporal integration processes occur at a higher stage of the auditory system than the generation site of the eABR. In order to locate this mechanism, additional measures of cortical responses are currently under study.

Published
2020
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43. Liste des collaborateurs

Author

Alaeddine-Lejalle, Catherine, primary, Amor-Sahli, Mélika, additional, Bailhache, Axelle, additional, Bartoli, Jean-Michel, additional, Benoudiba, Farida, additional, Blanc, Raphaël, additional, Bléry, Michel, additional, Boccara-Rodriguez, Florence, additional, Bonneville, Fabrice, additional, Boukhelifa, Mokran, additional, Bourdet, Christopher, additional, Bourelière, Brigitte, additional, Brunel, Hervé, additional, Cassagneau, Pierre, additional, Caudal, Delphine, additional, Chagnaud, Christophe, additional, Champsaur, Pierre, additional, Chapon, Frédérique, additional, Charrier, Jean-Baptiste, additional, Chevalier, Dominique, additional, Clarençon, Frédéric, additional, Cohen, Frédéric, additional, Craighero, Fabien, additional, Desmot, Florian, additional, Devèze, Arnaud, additional, Dory-Lautrec, Philippe, additional, Drier, Aurélie, additional, Dubrulle, Frédérique, additional, El Amri, Aïda, additional, Facon, David, additional, Ferrié, Jean-Claude, additional, Gaillandre, Loïc, additional, Gentric, Jean-Christophe, additional, Girard, Nadine, additional, Guenoun, Daphné, additional, Jacquier, Alexis, additional, Klossek, Jean-Michel, additional, Lavieille, Jean-Pierre, additional, Lefèvre, Marine, additional, Louis, Guillaume, additional, Magnan, Jacques-Paul, additional, Marciano-Chagnaud, Sandrine, additional, Marsault, Claude, additional, Martin-Duverneuil, Nadine, additional, Meriot, Philippe, additional, Muller, Cyril, additional, Monnet, Olivier, additional, Moulin, Guy, additional, Perie, Sophie, additional, Piana, Gilles, additional, Piekarski, Jean-Daniel, additional, Placko-Parola, Géraldine, additional, Siles, Pascale, additional, Souillard-Scemama, Raphaëlle, additional, Tassart, Marc, additional, Thomassin, Jean-Marc, additional, Varoquaux, Arthur, additional, Vidal, Vincent, additional, Williams, Marc, additional, and Wikberg-Lafont, Emilie, additional

Published
2010
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45. Intratemporal facial nerve schwannomas: multicenter experience of 80 cases

Author

Loos, Elke, primary, Verhaert, Nicolas, additional, Darrouzet, Vincent, additional, Godey, Benoit, additional, Linder, Thomas, additional, Vincent, Christophe, additional, Lavieille, Jean Pierre, additional, Schmerber, Sébastien, additional, Lescanne, Emmanuel, additional, Trabalzini, Franco, additional, De Foer, Bert, additional, Van Havenbergh, Tony, additional, and Somers, Thomas, additional

Published
2020
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47. Radiology Quiz Case 2

Author

Rameh, Charbel, Lavieille, Jean-Pierre, Magnan, Jacques, and Deveze, Arnaud

Published
2010

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