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1. Design of Multi-Component Reactions

Author

Zhu, Jieping, Kaïm, Laurent El, Tron, Gian Cesare, Lavilla, Rodolfo, Banfi, Luca, Basso, Andrea, Cerulli, Valentina, Guanti, Giuseppe, Lecinska, Paulina, Riva, Renata, Arévalo, M. J., Kielland, N., Masdeu, C., Miguel, M., Isambert, N., Lavilla, R., Medvedeva, Alevtina S., Novokshonov, Vladimir V., Novokshonova, Irina A., Demina, Maria M., Kon’kova, Tatyana V., Shklyaev, Yurii V., Rozhkova, Yulia S., Vshivkova, Tatiana S., Stryapunina, Olga G., Glushkov, Vladimir A., Kharitonova, Anastasia V., Fisyuk, Alexander S., Mukanov, Aleksey Y., Poendaev, Nicolay V., Gulevich, Anton V., Nenajdenko, Valentine G., Ivantsova, Maria N., Tokareva, Maria I., Mironov, Maxim A., Mokrushin, Vladimir S., Pirali, Tracey, Rozentsveig, Igor B., Popov, Aleksandr V., Levkovskaya, Galina G., Chernyshev, Kirill A., Krivdin, Leonid B., Tomilov, Yury V., Platonov, Dmitry N., Rulev, Alexander Y., Ushakov, Igor A., Vorobyeva, Alexandra, Ilyin, Alexey, Kysil, Volodimir, Ivachtchenko, Alexandre, and Mironov, Maxim A., editor

Published
2011
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2. Survival and quality of life in elderly patients in conservative management

Author

Rubio Rubio, M.V., Lou Arnal, L.M., Gimeno Orna, J.A., Munguía Navarro, P., Gutiérrez-Dalmau, A., Lambán Ibor, E., Paúl Ramos, J., Pernaute Lavilla, R., Campos Gutiérrez, B., and San Juan Hernández-Franch, A.

Subjects
Aged, 80 and over, Inflammation, Male, Malnutrition, 030232 urology & nephrology, Comorbidity, Conservative Treatment, Prognosis, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, Survival Rate, 03 medical and health sciences, 0302 clinical medicine, Nephrology, Parathyroid Hormone, Quality of Life, Humans, Female, 030212 general & internal medicine, Prospective Studies, Renal Insufficiency, Chronic, Geriatric Assessment, Serum Albumin
Abstract

Introduction: Conservative Management (CM) has become a therapeutic option in Advanced Chronic Kidney Disease in the elderly. However, there is a lack of evidence about prognosis of these patients in terms of survival and health related quality of life (HRQoL). Objective: Establish predictive variables associated with mortality and analyse HRQoL in CM patients. Patients and methods: Prospective cohort study. An assessment of renal function parameters and a comprehensive geriatric assessment were made, including: analysis of comorbidity, functional, cognitive, fragility, nutritional, social and HRQoL status. Results: 82 patients with a mean age of 84 years and significant pluripathology were studied: 56% had history of vascular event and Charlson >8. The mortality rate was 23/1000 patients per month, with a homogeneous mortality rate after 6 months.Survival differed significantly depending on whether they presented with a previous vascular event (36.7 vs. 14.8; p = 0.028), Charlson score ≥ 10 (42 vs. 17; p = 0.002), functional status (48.4 vs. 19; p = 0.002) and fragility (27 vs. 10; p = 0.05). Mortality predictors included eGFR and proteinuria, the presence of previous vascular events, Charlson comorbidity score, malnutrition-inflammation parameters (albumin and MNA score), degree of dependency, physical HRQoL and increase of PTH level. The presence of previous vascular event, comorbidity, decreased albumin and elevated PTH were independent predictors of mortality. HRQoL remained stable over time and no significant worsening occurred during treatment. Conclusions: Having knowledge of the factors associated with mortality and HRQoL assessment can be a useful tool to helping decision making during CM. Previous vascular events, comorbidity, decreased albumin and increased PTH were independent predictors of mortality. Resumen: Introducción: El tratamiento renal conservador (TRC) se ha convertido en una opción terapéutica en la enfermedad renal crónica avanzada en ancianos. Se sabe poco sobre la evolución pronóstica de estos pacientes en términos de supervivencia y calidad de vida relacionada con la salud (CVRS). Objetivo: Establecer variables predictivas de mortalidad y analizar la CVRS en los pacientes en TRC. Pacientes y métodos: Estudio de cohortes prospectivo. Se realizó una valoración de parámetros de función renal y evaluación geriátrica integral: análisis de comorbilidad, situación funcional, cognitiva, fragilidad, nutricional, social y CVRS. Resultados: Se evaluaron 82 pacientes, con una edad media de 84 años e importante pluripatología: el 56% tenía antecedentes de evento vascular y Charlson > 8. La tasa de mortalidad fue de 23/1.000 pacientes-mes, con un ritmo de mortalidad homogéneo a partir de los 6 meses.La supervivencia difirió significativamente si presentaban evento vascular previo (36,7 vs. 14,8; p = 0,028), Charlson ≥ 10 (42 vs. 17; p = 0,002), grado de dependencia (48,4 vs. 19; p = 0,002) y fragilidad (27 vs. 10; p = 0,05).Fueron predictores de mortalidad: eFG y proteinuria, presencia de evento vascular previo, comorbilidad de Charlson, parámetros de malnutrición-inflamación (albúmina y puntuación MNA), grado de dependencia, CVRS física y aumento de PTH. La presencia de evento vascular previo, comorbilidad, albúmina descendida y elevación de PTH fueron predictores independientes de mortalidad. La CVRS se mantuvo estable y no se produjo empeoramiento significativo durante el tratamiento. Conclusiones: El conocimiento de los factores asociados con mortalidad y la evaluación de la CVRS puede ser útil como herramienta en la toma de decisiones en TRC. La presencia de evento vascular previo, comorbilidad, albúmina disminuida y el aumento de PTH fueron predictores independientes de mortalidad. Keywords: Conservative management, Survival, Elderly, Advanced chronic kidney disease, Palabras clave: Manejo conservador, Supervivencia, Ancianos, Enfermedad renal crónica avanzada

Published
2019

3. Design of Multi-Component Reactions

Author

Zhu, Jieping, primary, Kaïm, Laurent El, additional, Tron, Gian Cesare, additional, Lavilla, Rodolfo, additional, Banfi, Luca, additional, Basso, Andrea, additional, Cerulli, Valentina, additional, Guanti, Giuseppe, additional, Lecinska, Paulina, additional, Riva, Renata, additional, Arévalo, M. J., additional, Kielland, N., additional, Masdeu, C., additional, Miguel, M., additional, Isambert, N., additional, Lavilla, R., additional, Medvedeva, Alevtina S., additional, Novokshonov, Vladimir V., additional, Novokshonova, Irina A., additional, Demina, Maria M., additional, Kon’kova, Tatyana V., additional, Shklyaev, Yurii V., additional, Rozhkova, Yulia S., additional, Vshivkova, Tatiana S., additional, Stryapunina, Olga G., additional, Glushkov, Vladimir A., additional, Kharitonova, Anastasia V., additional, Fisyuk, Alexander S., additional, Mukanov, Aleksey Y., additional, Poendaev, Nicolay V., additional, Gulevich, Anton V., additional, Nenajdenko, Valentine G., additional, Ivantsova, Maria N., additional, Tokareva, Maria I., additional, Mironov, Maxim A., additional, Mokrushin, Vladimir S., additional, Pirali, Tracey, additional, Zhu, Jieping, additional, Rozentsveig, Igor B., additional, Popov, Aleksandr V., additional, Levkovskaya, Galina G., additional, Chernyshev, Kirill A., additional, Krivdin, Leonid B., additional, Tomilov, Yury V., additional, Platonov, Dmitry N., additional, Rulev, Alexander Y., additional, Ushakov, Igor A., additional, Vorobyeva, Alexandra, additional, Ilyin, Alexey, additional, Kysil, Volodimir, additional, and Ivachtchenko, Alexandre, additional

Published
2010
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31. Polarization of x-ray emission lines from heliumlike scandium as a probe of the hyperfine interaction

Author

Henderson, J. R., primary, Beiersdorfer, P., additional, Bennett, C. L., additional, Chantrenne, S., additional, Knapp, D. A., additional, Marrs, R. E., additional, Schneider, M. B., additional, Wong, K. L., additional, Doschek, G. A., additional, Seely, J. F., additional, Brown, C. M., additional, LaVilla, R. E., additional, Dubau, J., additional, and Levine, M. A., additional

Published
1990
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33. Chromenopyridines: Promising Scaffolds for Medicinal and Biological Chemistry

Author

J. Nunez-Vergara, L., A. Squella, J., A. Navarrete-Encina, P., Vicente-Garcia, E., Preciado, S., and Lavilla, R.

Abstract

Chromenopyridines constitute a structurally diverse class of compounds with a wide range of bioactivities and increasing presence in drugs. Here we analyze the scope of the synthetic methodology to access this nucleus with emphasis on multicomponent reactions and robust methodologies. Reactivity issues, medicinal applications and other properties are also reviewed.

Published
2011

35. Multicomponent Reactions with Dihydroazines:  Efficient Synthesis of a Diverse Set of Pyrido-Fused Tetrahydroquinolines

Author

Carranco, I., Diaz, J. L., Jimenez, O., Vendrell, M., Albericio, F., Royo, M., and Lavilla, R.

Abstract

A multicomponent assembly of pyrido-fused tetrahydroquinolines is accomplished in a one-pot process from the interaction of dihydroazines, aldehydes, and anilines. A rational screening of the different components and parameters of this reaction, such as the range of reactive starting materials, catalysts and reaction conditions (solvent range; thermal, high pressure- and microwave-promoted processes) is carried out. Optimized conditions allow an efficient preparation of pyrido-fused tetrahydroquinolines with good yields, bypassing the biomimetic NADH-like reductive pathway which is typical in the interaction of dihydropyridines with carbonyl compounds and amines. Furthermore, solid-supported versions of the process have been developed, which should facilitate the preparation of libraries.

Published
2005

36. Dihydropyridine-Based Multicomponent Reactions. Efficient Entry into New Tetrahydroquinoline Systems through Lewis Acid-Catalyzed Formal [4 + 2] Cycloadditions

Author

Lavilla, R., Bernabeu, M. C., Carranco, I., and Diaz, J. L.

Abstract

The three-component reaction of dihydropyridines, aldehydes, and p-methylaniline efficiently forms highly substituted tetrahydroquinolines in a stereoselective manner through a Lewis acid-catalyzed formal [4 + 2] cycloaddition. InCl3 and Sc(OTf)3 are the catalysts of choice for this process. The in situ generation of a reactive 1,4-dihydropyridine through the regioselective nucleophilic addition of cyanide to pyridinium salts allows a one-pot four-component transformation.

Published
2003

37. 28P CHKB muscular dystrophy: beyond megamitochondria.

Author

Bergada, A. Codina, Nascimento, A., Lavilla, R., Ortez, C., Natera-de Benito, D., Expósito, J., Estévez-Arias, B., Carrera, L., Martorell, L., Isaí, A., Colomer, J., and Jou, C.

Subjects
*MUSCULAR dystrophy, *LIPID metabolism, *FIBROBLASTS, *THREE-dimensional imaging, *FATTY acids, *FACIOSCAPULOHUMERAL muscular dystrophy
Abstract

CHKB gene encodes choline kinase enzyme that catalyses the first step in membrane phospholipid phosphatidylcholine synthesis. Mutations in the CHKB gene lead to a muscular dystrophy, which has a characteristic histopathological pattern showing peripheral megamitochondria distribution, which has become the guide for histological diagnosis. However, megamitochondria is not exclusive to CHKB patients, and there are other histological features that go along this muscular dystrophy. A review of histological characteristics from muscles of 3 patient and fibroblasts of one of them with CHKB mutations was performed, to establish a detailed histological and morphological description of other guide signs beyond megamitochondria. Mitochondria, lipid, peroxisome, autophagosome and CHKB immunopathological studies were performed in genetically confirmed CHKB patients, control muscular biopsies and fibroblast culture. Imaging and 3D studies were performed using a TCS SP8 confocal microscope. Muscle biopsy of the 3 cases showed typical distribution of megamitochondria at fibre periphery with normal respiratory chain activity. Fibroblasts did not show megamitochondria, but minor changes were observed in mitochondria network. An increase in number and size of lipid droplets were observed. p62 aggregates were visible both in muscle and fibroblasts. No colocalization between lipid droplets and p62 was identified. Peroxisome signal was reduced in muscle as well as in fibroblasts. A decreased signal in CHKB immunofluorescence was appreciated in patient fibroblasts but not in muscle. The presence of megamitochondria and its distribution in muscle biopsies from CHKB patients continues to be the guiding sign in histopathological diagnosis. These changes are not so evident in fibroblasts. CHKB patients have alterations in lipid metabolism due to a disability in fatty acids metabolism, evidenced by an increase in the number and size of lipid droplets. These patients present the autophagy pathway activated. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Optical Constants of Germanium

Author

LaVilla, R. E. and Mendlowitz, H.

Abstract

The authors have attempted to assess the disagreement of various investigators on the optical properties of germanium in the far uv. The analyis subjected the reported data, out to about 25 eV, to the following tests: (1) an internal consistency check when possible by applying the Kronig–Kramers dispersion relations to the optical constants; (2) an evaluation of the optical oscillator strength distribution for the spectrum under study; (3) correlation of the values of Im(1/∊*) from the optical data with the characteristic electron energy loss spectrum for the material; and (4) evaluation of the oscillator strength sum for the electron energy loss distribution. A set of optical constants derived from the characteristic electron energy loss data is presented and discussed. Also, an estimate of the source of errors incurred in the application of the Kronig–Kramers dispersion relations are given and discussed in terms of optical data.

Published
1967

39. Optical Properties of Beryllium in the Ultraviolet from Electron Energy Absorption

Author

LaVilla, R. E. and Mendlowitz, H.

Abstract

A method for obtaining the optical constants of beryllium in the far ultraviolet based upon electron energy loss experiments is described. This method correlates the electron interaction with the target material to the optical properties of the material. The n and k values and the reflectivity are presented for photon energies in the range 12 ≤ E ≤ 28 eV. The n and k values are given and are checked for self-consistency by means of the Kronig-Kramers dispersion relations. The optical data have been fitted by a two-parameter Drude model with a plasma energy of ?ωp = 18.4 eV and a relaxation time of 1.4 × 10^−16 sec.

Published
1965

40. Oxidative Diphosphonylation of 1,4-Dihydropyridines and Pyridinium Salts

Author

Lavilla, R., Spada, A., and Bosch, J.

Abstract

An oxidative double phosphonylation of dihydropyridines 1 and pyridinium salts 2 is achieved through the use of dialkyl phosphites, DDQ, and triethylamine. Acceptable to good yields of 2,6-diphosphonylated-1,2-dihydropyridines 3 are obtained in a one-pot reaction involving tandem nucleophilic addition/oxidation processes. Isomerization of 3 to the more stable 2,4-diphosphonylated-1,4-dihydropyridine 4 was observed in some cases.

Published
2000

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