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2. Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome

Author

Friedman, Gil, Levi-Galibov, Oshrat, David, Eyal, Bornstein, Chamutal, Giladi, Amir, Dadiani, Maya, Mayo, Avi, Halperin, Coral, Pevsner-Fischer, Meirav, Lavon, Hagar, Mayer, Shimrit, Nevo, Reinat, Stein, Yaniv, Balint-Lahat, Nora, Barshack, Iris, Ali, H. Raza, Caldas, Carlos, Nili-Gal-Yam, Einav, Alon, Uri, Amit, Ido, and Scherz-Shouval, Ruth

Published
2020
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5. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

Author

Levi-Galibov, Oshrat, Lavon, Hagar, Wassermann-Dozorets, Rina, Pevsner-Fischer, Meirav, Mayer, Shimrit, Wershof, Esther, Stein, Yaniv, Brown, Lauren E., Zhang, Wenhan, Friedman, Gil, Nevo, Reinat, Golani, Ofra, Katz, Lior H., Yaeger, Rona, Laish, Ido, Porco, John A., Sahai, Erik, Shouval, Dror S., Kelsen, David, and Scherz-Shouval, Ruth

Published
2020
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8. Supplementary Table 7 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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9. Supplementary Table 9 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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10. Supplementary Table 11 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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11. Supplementary Materials&Methods and Supplementary Figures 1-6 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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12. Supplementary Table 5 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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13. Supplementary Table 6 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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14. Supplementary Table 4 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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15. Data from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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16. Supplementary Table 8 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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17. Supplementary Table 3 from Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, primary, Goshen-Lago, Tal, primary, Diment, Judith, primary, Stein, Yaniv, primary, Lavon, Hagar, primary, Mayer, Shimrit, primary, Levi-Galibov, Oshrat, primary, Friedman, Gil, primary, Ofir-Birin, Yifat, primary, Syu, Li-Jyun, primary, Migliore, Cristina, primary, Shimoni, Eyal, primary, Stemmer, Salomon M., primary, Brenner, Baruch, primary, Dlugosz, Andrzej A., primary, Lyden, David, primary, Regev-Rudzki, Neta, primary, Ben-Aharon, Irit, primary, and Scherz-Shouval, Ruth, primary

Published
2023
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19. Abstract LB009: Dynamic changes in the compositions of cancer associated-fibroblasts correlate with clinical outcome in breast cancer

Author

Friedman, Gil, primary, Levi-Galibov, Oshrat, additional, David, Eyal, additional, Bornstein, Chamutal, additional, Giladi, Amir, additional, Dadiani, Maya, additional, Mayo, Avi, additional, Halperin, Coral, additional, Pevsner-Fischer, Meirav, additional, Lavon, Hagar, additional, Mayer, Shimrit, additional, Nevo, Reinat, additional, Stein, Yaniv, additional, Balint-Lahat, Nora, additional, Barshack, Iris, additional, Ali, H. Raza, additional, Caldas, Carlos, additional, Gal-Yam, Einav Nili, additional, Alon, Uri, additional, Amit, Ido, additional, and Scherz-Shouval, Ruth, additional

Published
2021
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20. Abstract LB204: HSF1 promotes inflammation induced tumor development through ECM remodeling

Author

Galibov, Oshrat Levi, primary, Lavon, Hagar, additional, Wassermann-Dozorets, Rina, additional, Pevsner-Fischer, Meirav, additional, Mayer, Shimrit, additional, Wershof, Esther, additional, Stein, Yaniv, additional, Brown, Lauren E., additional, Zhang, Wenhan, additional, Friedman, Gil, additional, Nevo, Reinat, additional, Golani, Ofra, additional, Katz, Lior H., additional, Yaeger, Rona, additional, Laish, Ido, additional, Porco, John A., additional, Sahai, Erik, additional, Shouval, Dror S, additional, Kelsen, David, additional, and Scherz-Shouval, Ruth, additional

Published
2021
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21. Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Author

Grunberg, Nil, primary, Pevsner-Fischer, Meirav, additional, Goshen-Lago, Tal, additional, Diment, Judith, additional, Stein, Yaniv, additional, Lavon, Hagar, additional, Mayer, Shimrit, additional, Levi-Galibov, Oshrat, additional, Friedman, Gil, additional, Ofir-Birin, Yifat, additional, Syu, Li-Jyun, additional, Migliore, Cristina, additional, Shimoni, Eyal, additional, Stemmer, Salomon M., additional, Brenner, Baruch, additional, Dlugosz, Andrzej A., additional, Lyden, David, additional, Regev-Rudzki, Neta, additional, Ben-Aharon, Irit, additional, and Scherz-Shouval, Ruth, additional

Published
2021
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23. Cancer-associated fibroblast compositions change with breast-cancer progression linking S100A4 and PDPN ratios with clinical outcome

Author

Friedman, Gil, primary, Levi-Galibov, Oshrat, additional, David, Eyal, additional, Bornstein, Chamutal, additional, Giladi, Amir, additional, Dadiani, Maya, additional, Mayo, Avi, additional, Halperin, Coral, additional, Pevsner-Fischer, Meirav, additional, Lavon, Hagar, additional, Nevo, Reinat, additional, Stein, Yaniv, additional, Ali, H. Raza, additional, Caldas, Carlos, additional, Nili-Gal-Yam, Einav, additional, Alon, Uri, additional, Amit, Ido, additional, and Scherz-Shouval, Ruth, additional

Published
2020
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24. Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects

Author

Matzner, Pini, Sorski, Liat, Shaashua, Lee, Elbaz, Ely, Lavon, Hagar, Melamed, Rivka, Rosenne, Ella, Gotlieb, Neta, Benbenishty, Amit, Reed, Steve G., and Ben-Eliyahu, Shamgar

Subjects
Male, Mice, Inbred BALB C, Antineoplastic Agents, Neoplasms, Experimental, Flow Cytometry, Article, Rats, Inbred F344, Rats, Toll-Like Receptor 4, Mice, Lipid A, Adjuvants, Immunologic, Glucosides, Cell Line, Tumor, Animals, Female, Neoplasm Metastasis, Perioperative Period
Abstract

The use of TLR agonists as an anti-cancer treatment is gaining momentum given their capacity to activate various host cellular responses through the secretion of inflammatory cytokines and type-I interferons. It is now also recognized that the perioperative period is a window of opportunity for various interventions aiming at reducing the risk of cancer metastases – the major cause of cancer related death. However, immune-stimulatory approach has not been used perioperatively given several contraindications to surgery. To overcome these obstacles, in the current study we employed the newly introduced, fully synthetic TLR-4 agonist, Glucopyranosyl Lipid-A (GLA-SE), in various models of cancer metastases, and in the context of acute stress or surgery. Without exerting evident adverse effects, a single systemic administration of GLA-SE rapidly and dose dependently elevated both innate and adaptive immunity in the circulation, lungs, and the lymphatic system. Importantly, GLA-SE treatment led to reduced metastatic development of a mammary adenocarcinoma and a colon carcinoma by approximately 40-75% in F344 rats and BALB/c mice, respectively, at least partly through elevating marginating-pulmonary NK cell cytotoxicity. GLA-SE is safe and well tolerated in humans, and currently is used as an adjuvant in phase-II clinical trials. Given that the TLR-4 receptor and its signaling cascade is highly conserved throughout evolution, our current results suggest that GLA-SE may be a promising immune stimulatory agent in the context of oncological surgeries, aiming to reduce long-term cancer recurrence.

Published
2015

27. Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects.

Author

Matzner, Pini, Sorski, Liat, Shaashua, Lee, Elbaz, Ely, Lavon, Hagar, Melamed, Rivka, Rosenne, Ella, Gotlieb, Neta, Benbenishty, Amit, Reed, Steve G., and Ben‐Eliyahu, Shamgar

Abstract

The use of TLR agonists as an anti-cancer treatment is gaining momentum given their capacity to activate various host cellular responses through the secretion of inflammatory cytokines and type-I interferons. It is now also recognized that the perioperative period is a window of opportunity for various interventions aiming at reducing the risk of cancer metastases-the major cause of cancer related death. However, immune-stimulatory approach has not been used perioperatively given several contraindications to surgery. To overcome these obstacles, in this study, we used the newly introduced, fully synthetic TLR-4 agonist, Glucopyranosyl Lipid-A (GLA-SE), in various models of cancer metastases, and in the context of acute stress or surgery. Without exerting evident adverse effects, a single systemic administration of GLA-SE rapidly and dose dependently elevated both innate and adaptive immunity in the circulation, lungs and the lymphatic system. Importantly, GLA-SE treatment led to reduced metastatic development of a mammary adenocarcinoma and a colon carcinoma by approximately 40-75% in F344 rats and BALB/c mice, respectively, at least partly through elevating marginating-pulmonary NK cell cytotoxicity. GLA-SE is safe and well tolerated in humans, and currently is used as an adjuvant in phase-II clinical trials. Given that the TLR-4 receptor and its signaling cascade is highly conserved throughout evolution, our current results suggest that GLA-SE may be a promising immune stimulatory agent in the context of oncological surgeries, aiming to reduce long-term cancer recurrence. [ABSTRACT FROM AUTHOR]

Published
2016
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