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5. Carotid Artery Disease

Author

Lal, Brajesh K., Marshall, Randolph, Lazar, Ronald M., Lazar, Ronald M., editor, Pavol, MaryKay A., editor, and Browndyke, Jeffrey N., editor

Published
2020
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9. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort.

Author

Singh, Sanjula D., Rivier, Cyprien A., Papier, Keren, Chemali, Zeina, Gutierrez-Martinez, Leidys, Parodi, Livia, Mayerhofer, Ernst, Senff, Jasper, Clocchiatti-Tuozzo, Santiago, Nunley, Courtney, Newhouse, Amy, An Ouyang, Westover, M. Brandon, Tanzi, Rudolph E., Lazar, Ronald M., Pikula, Aleksandra, Ibrahim, Sarah, Brouwers, H. Bart, Howard, Virginia J., and Howard, George

Subjects
DISEASE risk factors, PROPORTIONAL hazards models, PREDICTIVE validity, DEMENTIA, RISK sharing
Abstract

Introduction: The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasingly recognized to share risk factors with stroke and dementia, and is an important clinical endpoint for brain health, we tested the hypothesis that a higher BCS is associated with a reduced incidence of future depression. Additionally, we examined its association with a brain health composite outcome comprising stroke, dementia, and late-life depression. Methods: The BCS was derived from the United Kingdom Biobank baseline evaluation in participants with complete data on BCS items. Associations of BCS with the risk of subsequent incident late-life depression and the composite brain health outcome were estimated using multivariable Cox proportional hazard models. These models were adjusted for age at baseline and sex assigned at birth. Results: A total of 363,323 participants were included in this analysis, with a median BCS at baseline of 12 (IQR: 11-14). There were 6,628 incident cases of late-life depression during a median follow-up period of 13 years. Each five-point increase in baseline BCS was associated with a 33% lower risk of incident late-life depression (95% CI: 29%-36%) and a 27% lower risk of the incident composite outcome (95% CI: 24%-30%). Discussion: These data further demonstrate the shared risk factors across depression, dementia, and stroke. The findings suggest that a higher BCS, indicative of healthier lifestyle choices, is significantly associated with a lower incidence of late-life depression and a composite brain health outcome. Additional validation of the BCS is warranted to assess the weighting of its components, its motivational aspects, and its acceptability and adaptability in routine clinical care worldwide. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Defining Optimal Brain Health in Adults

Author

Gorelick, Philip B, Furie, Karen L, Iadecola, Costantino, Smith, Eric E, Waddy, Salina P, Lloyd-Jones, Donald M, Bae, Hee-Joon, Bauman, Mary Ann, Dichgans, Martin, Duncan, Pamela W, Girgus, Meighan, Howard, Virginia J, Lazar, Ronald M, Seshadri, Sudha, Testai, Fernando D, van Gaal, Stephen, Yaffe, Kristine, Wasiak, Hank, and Zerna, Charlotte

Subjects
Health Services and Systems, Health Sciences, Acquired Cognitive Impairment, Aging, Prevention, Brain Disorders, Neurosciences, Cardiovascular, Dementia, Behavioral and Social Science, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Nutrition, Neurological, Stroke, Good Health and Well Being, Adult, Advisory Committees, American Heart Association, Brain, Cognition Disorders, Health Behavior, Health Promotion, Humans, United States, AHA Scientific Statements, aging, brain, cognitive dysfunction, prevention and control, risk factors, stroke, American Heart Association/American Stroke Association, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Cognitive function is an important component of aging and predicts quality of life, functional independence, and risk of institutionalization. Advances in our understanding of the role of cardiovascular risks have shown them to be closely associated with cognitive impairment and dementia. Because many cardiovascular risks are modifiable, it may be possible to maintain brain health and to prevent dementia in later life. The purpose of this American Heart Association (AHA)/American Stroke Association presidential advisory is to provide an initial definition of optimal brain health in adults and guidance on how to maintain brain health. We identify metrics to define optimal brain health in adults based on inclusion of factors that could be measured, monitored, and modified. From these practical considerations, we identified 7 metrics to define optimal brain health in adults that originated from AHA's Life's Simple 7: 4 ideal health behaviors (nonsmoking, physical activity at goal levels, healthy diet consistent with current guideline levels, and body mass index

Published
2017

11. Abstract WMP19: A Brain Care Score for Risk of Late-Life Depression: Data From the UK Biobank Cohort

Author

Singh, Sanjula D, primary, Rivier, Cyprien, additional, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Chemali, Zeina, additional, Guiterrez-Martinez, Leidys, additional, Mallick, Akashleena, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Senff, Jasper, additional, Kourkoulis, Christina, additional, Marini, Sandro, additional, Clocchiatti-Tuozzo, Santiago, additional, Nunley, Courtney, additional, Newhouse, Amy, additional, Ouyang, An, additional, Westover, Michael B, additional, Tanzi, Rudolph, additional, Lazar, Ronald M, additional, Pikula, Aleksandra, additional, Ibrahim, Sarah, additional, Brouwers, H, additional, Howard, Virginia J, additional, Howard, George, additional, Yechoor, Nirupama, additional, van Duijn, Cornelia, additional, Littlejohns, Thomas, additional, Sheth, Kevin N, additional, Rosand, Jonathan, additional, Fricchione, Gregory, additional, Anderson, Christopher D, additional, and Falcone, Guido J, additional

Published
2024
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12. Abstract 37: The Brain Care Score and Neuroimaging Markers in Asymptomatic Individuals in the UK Biobank

Author

Rivier, Cyprien, primary, Singh, Sanjula D, additional, Senff, Jasper, additional, Marini, Sandro, additional, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Conroy, Megan, additional, Chemali, Zeina, additional, Gutierrez, Leidys, additional, Mallick, Akashleena, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Kourkoulis, Christina, additional, Clocchiatti-Tuozzo, Santiago, additional, Nunley, Courtney, additional, Payabvash, Sam, additional, Newhouse, Amy, additional, Ouyang, An, additional, Lazar, Ronald M, additional, Westover, Michael B, additional, Pikula, Aleksandra, additional, Ibrahim, Sarah, additional, Brouwers, Bart, additional, Howard, Virginia J, additional, Howard, George, additional, Yechoor, Nirupama, additional, van Duijn, Cornelia, additional, Littlejohns, Thomas, additional, Tanzi, Rudolph, additional, Fricchione, Gregory, additional, Sheth, Kevin N, additional, Rosand, Jonathan, additional, Anderson, Christopher D, additional, and Falcone, Guido J, additional

Published
2024
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13. Abstract WMP18: A Brain Care Score for Dementia and Stroke: Data From the UK Biobank Cohort

Author

Singh, Sanjula D, primary, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Conroy, Megan, additional, Senff, Jasper, additional, Chemali, Zeina, additional, Gutierrez-Martinez, Leidys, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Marini, Sandro, additional, Nunley, Courtney, additional, Kourkoulis, Christina, additional, Newhouse, Amy, additional, Ouyang, An, additional, Brouwers, H B, additional, Westover, Brandon, additional, Rivier, Cyprien, additional, Falcone, Guido J, additional, Howard, Virginia J, additional, Howard, George, additional, Sheth, Kevin N, additional, Yechoor, Nirupama, additional, Lazar, Ronald M, additional, Anderson, Christopher D, additional, Tanzi, Rudolph, additional, Fricchione, Gregory, additional, Littlejohns, Thomas, additional, and Rosand, Jonathan, additional

Published
2024
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14. Abstract TP13: Association Between Education Level and Post-Stroke Cognitive Decline - A Pooled Cohort Analysis of Four Cohorts

Author

Springer, Mellanie V, primary, Whitney, Rachael T, additional, Ye, Wen, additional, Briceño, Emily M, additional, Gross, Alden L, additional, Aparicio, Hugo J, additional, Beiser, Alexa S, additional, Burke, James F, additional, Elkind, Mitchell S, additional, Ferber, Rebecca A, additional, Giordani, Bruno J, additional, Gottesman, Rebecca F, additional, Hayward, Rodney A, additional, Howard, Virginia J, additional, Kollipara, Adam S, additional, Koton, Silvia, additional, Lazar, Ronald M, additional, Longstreth, William T, additional, Pendlebury, Sarah T, additional, Sussman, Jeremy B, additional, Thacker, Evan L, additional, and Levine, Deborah A, additional

Published
2024
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15. Abstract 72: Association Between Stroke Subtype and Post-Stroke Cognitive Decline: A Pooled Cohort Analysis of Four Cohorts

Author

Levine, Deborah A, primary, Whitney, Rachael T, additional, Ye, Wen, additional, Briceño, Emily M, additional, Gross, Alden L, additional, Aparicio, Hugo J, additional, Beiser, Alexa S, additional, Elkind, Mitchell S, additional, Ferber, Rebecca A, additional, Giordani, Bruno J, additional, Gottesman, Rebecca F, additional, Howard, Virginia J, additional, Kollipara, Adam S, additional, Koton, Silvia, additional, Lazar, Ronald M, additional, Pendlebury, Sarah T, additional, Seshadri, Sudha, additional, Springer, Mellanie V, additional, Sussman, Jeremy B, additional, Burke, James F, additional, and Hayward, Rodney A, additional

Published
2024
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18. Stroke Recovery and Rehabilitation Research: Issues, Opportunities, and the National Institutes of Health StrokeNet.

Author

Cramer, Steven C, Wolf, Steven L, Adams, Harold P, Jr, Chen, Daofen, Dromerick, Alexander W, Dunning, Kari, Ellerbe, Caitlyn, Grande, Andrew, Janis, Scott, Lansberg, Maarten G, Lazar, Ronald M, Palesch, Yuko Y, Richards, Lorie, Roth, Elliot, Savitz, Sean I, Wechsler, Lawrence R, Wintermark, Max, and Broderick, Joseph P

Subjects
Clinical Trials as Topic, Humans, National Institutes of Health (U.S.), Rehabilitation Research, Research Design, Stroke Rehabilitation, United States
Published
2017

25. Stroke

Author

Lazar, Ronald M., Kreutzer, Jeffrey S., editor, DeLuca, John, editor, and Caplan, Bruce, editor

Published
2018
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27. Cerebral blood flow and neurocognition in patients undergoing transcatheter aortic valve replacement for severe aortic stenosis.

Author

Lazar, Ronald M, Myers, Terina, Gropen, Toby I, Leesar, Massoud A, Davies, James, Gerstenecker, Adam, Norling, Amani, Pavol, Marykay A, Marshall, Randolph S, and Kodali, Susheel

Subjects
HEART valve prosthesis implantation, CEREBRAL circulation, AORTIC valve transplantation, AORTIC stenosis, FLOW velocity, CARDIAC output, HEART failure, AORTIC valve insufficiency
Abstract

Aims: Aortic valve stenosis (AS) results in higher systolic pressure to overcome resistance from the stenotic valve, leading to heart failure and decline in cardiac output. There has been no assessment of cerebral blood flow (CBF) association with neurocognition in AS or the effects of valve replacement. The goal was to determine if AS is associated with altered cerebral haemodynamics and impaired neurocognition, and whether transcatheter aortic valve replacement (TAVR) improves haemodynamics and cognition. Methods and results: In 42 patients with planned TAVR, transcranial Doppler (TCD) assessed bilateral middle cerebral artery (MCA) mean flow velocities (MFVs); abnormality was <34.45 cm/s. The neurocognitive battery assessed memory, language, attention, visual–spatial skills, and executive function, yielding a composite Z-score. Impairment was <1.5 SDs below the normative mean. The mean age was 78 years, 59% Male, and the mean valve gradient was 46.87 mm/Hg. Mean follow-up was 36 days post-TAVR (range 27–55). Pre-TAVR, the mean MFV was 42.36 cm/s (SD = 10.17), and the mean cognitive Z-score was −0.22 SDs (range −1.99 to 1.08) below the normative mean. Among the 34 patients who returned after TAVR, the MFV was 41.59 cm/s (SD = 10.42), not different from baseline (P = 0.66, 2.28–3.67). Post-TAVR, average Z-scores were 0.17 SDs above the normative mean, not meeting the pre-specified threshold for a clinically significant 0.5 SD change. Conclusion: Among patients with severe AS, there was little impairment of MFV on TCD and no correlation with cognition. Transcatheter aortic valve replacement did not affect MFV or cognition. Assumptions about diminished CBF and improvement after TAVR were not supported. Graphical Abstract The relationship of cognition (Z-scores) to cerebral haemodynamics (mean flow velocity). Abnormality: ≥1.50 SD below normative means. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Effects of a brief HIIT intervention on cognitive performance in older women

Author

Norling, Amani M., primary, Gerstenecker, Adam, additional, Bolding, Mark S., additional, Hoef, Lawrence Ver, additional, Buford, Thomas, additional, Walden, Randall, additional, An, Hongyu, additional, Ying, Chunwei, additional, Myers, Terina, additional, Jones, Benjamin S., additional, Del Bene, Victor, additional, and Lazar, Ronald M., additional

Published
2023
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30. Neurocognition and Cerebral Lesion Burden in High-Risk Patients Before Undergoing Transcatheter Aortic Valve Replacement: Insights From the SENTINEL Trial

Author

Lazar, Ronald M., Pavol, Marykathryn A., Bormann, Tobias, Dwyer, Michael G., Kraemer, Carlye, White, Roseann, Zivadinov, Robert, Wertheimer, Jeffrey C., Thöne-Otto, Angelika, Ravdin, Lisa D., Naugle, Richard, Mechanic-Hamilton, Dawn, Garmoe, William S., Stringer, Anthony Y., Bender, Heidi A., Kapadia, Samir R., Kodali, Susheel, Ghanem, Alexander, Linke, Axel, Mehran, Roxana, Virmani, Renu, Nazif, Tamim, Parhizgar, Azin, and Leon, Martin B.

Published
2018
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31. National Institutes of Health StrokeNet During the Time of COVID-19 and Beyond

Author

Broderick, Joseph P., Elm, Jordan J., Janis, L. Scott, Zhao, Wenle, Moy, Claudia S., Dillon, Catherine R., Chimowitz, Marc I., Sacco, Ralph L., Cramer, Steven C., Wolf, Steven L., Johnston, Karen C., Saver, Jeffrey L., Marshall, Randolph S., Brown, Devin, Wintermark, Max, Elkind, Mitchell S.V., Kamel, Hooman, Tirschwell, David L., Longstreth, W.T., Chervin, Ronald D., Adeoye, Opeolu M., Barreto, Andrew D., Grotta, James C., Ramey, Sharon L., Lo, Warren D., Feng, Wuwei, Schlaug, Gottfried, Sheth, Kevin N., Selim, Magdy, Naidech, Andrew M., Lansberg, Maarten G., Lazar, Ronald M., Albers, Gregory W., Griffin, Jessica S., Sirline, Logan P., Frasure, Jamey, Wright, Clinton B., and Khatri, Pooja

Published
2020
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32. Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors

Author

Levine, Deborah A., primary, Chen, Bingxin, additional, Galecki, Andrzej T., additional, Gross, Alden L., additional, Briceño, Emily M., additional, Whitney, Rachael T., additional, Ploutz-Snyder, Robert J., additional, Giordani, Bruno J., additional, Sussman, Jeremy B., additional, Burke, James F., additional, Lazar, Ronald M., additional, Howard, Virginia J., additional, Aparicio, Hugo J., additional, Beiser, Alexa S., additional, Elkind, Mitchell S. V., additional, Gottesman, Rebecca F., additional, Koton, Silvia, additional, Pendlebury, Sarah T., additional, Sharma, Anu, additional, Springer, Mellanie V., additional, Seshadri, Sudha, additional, Romero, Jose R., additional, and Hayward, Rodney A., additional

Published
2023
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37. Cortical Thinning in High-Grade Asymptomatic Carotid Stenosis

Author

Marshall, Randolph S., primary, Liebeskind, David S., additional, III, John Huston, additional, Edwards, Lloyd J., additional, Howard, George, additional, Meschia, James F., additional, Brott, Thomas G., additional, Lal, Brajesh K., additional, Heck, Donald, additional, Lanzino, Giuseppe, additional, Sangha, Navdeep, additional, Kashyap, Vikram S., additional, Morales, Clarissa D., additional, Cotton-Samuel, Dejania, additional, Rivera, Andres M., additional, Brickman, Adam M., additional, and Lazar, Ronald M., additional

Published
2023
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40. Stroke

Author

Lazar, Ronald M., Kreutzer, Jeffrey S., editor, DeLuca, John, editor, and Caplan, Bruce, editor

Published
2011
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42. A-153 Characteristics of Patients Seeking Treatment for “Brain Fog” Secondary to Post-Acute Sequelae of COVID-19 (PASC) in the Deep South

Author

Robinson, Jamie Hansel, primary, Greenfield, Melissa J, additional, Lokken, Kristine, additional, Shah, Udit Vipul, additional, Agnihotri, Shruti P, additional, Wheeler, Pariya Fazeli, additional, Vance, David E, additional, Kennedy, Richard, additional, Gerstenecker, Adam, additional, Lazar, Ronald M, additional, Martin, Roy C, additional, and Gerstenecker, Kristen Triebel, additional

Published
2022
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43. A-159 Neurocognitive Performance in Post-Acute Sequelae of COVID-19 (PASC)

Author

Lokken, Kristine, primary, Greenfield, Melissa J, additional, Robinson, Jamie Hansel, additional, Shah, Udit Vipul, additional, Lazar, Ronald M, additional, Kennedy, Richard, additional, Martin, Roy C, additional, Gerstenecker, Kristen Triebel, additional, Gerstenecker, Adam, additional, Wheeler, Pariya Fazeli, additional, Agnihotri, Shruti P, additional, and Vance, David E, additional

Published
2022
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44. A-160 Neuropsychiatric Symptoms in Post-Acute Sequelae of COVID-19 (PASC)

Author

Greenfield, Melissa J, primary, Robinson, Jamie Hansel, additional, Wheeler, Pariya Fazeli, additional, Shah, Udit Vipul, additional, Vance, David E, additional, Agnihotri, Shruti P, additional, Kennedy, Richard, additional, Lokken, Kristine, additional, Gerstenecker, Kristen Triebel, additional, Gerstenecker, Adam, additional, Martin, Roy C, additional, and Lazar, Ronald M, additional

Published
2022
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