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6. Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb

Author

Lazaridis, Ioannis I., primary, Bosch, Angela J.T., additional, Keller, Lena, additional, Low, Andy J.Y., additional, Tamarelle, Jeanne, additional, Moser, Seraina O., additional, Winter, Denise V., additional, Gómez, Cristina, additional, Peterson, Caspar J., additional, Schneider, Romano, additional, Kraljevic, Marko, additional, Odermatt, Alex, additional, Vonaesch, Pascale, additional, Peterli, Ralph, additional, Delko, Tarik, additional, and Cavelti-Weder, Claudia, additional

Published
2024
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15. Correction to: Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members

Author

Reichert, Martin, Sartelli, Massimo, Weigand, Markus A., Hecker, Matthias, Oppelt, Philip U., Noll, Julia, Askevold, Ingolf H., Liese, Juliane, Padberg, Winfried, Coccolini, Federico, Catena, Fausto, Hecker, Andreas, Peckham-Cooper, Adam, Camacho-Ortiz, Adrian, Mastoraki, Aikaterini T., Landaluce-Olavarria, Aitor, Pal, Ajay Kumar, Kuriyama, Akira, Chichom-Mefire, Alain, Porcu, Alberto, Martínez-Pérez, Aleix, Karamarkovic, Aleksandar R., Osipov, Aleksei V., Coppola, Alessandro, Cucchetti, Alessandro, Spolini, Alessandro, Giordano, Alessio, Reinisch-Liese, Alexander, Kavalakat, Alfie J., Vasilescu, Alin, Alamin, Amin, Gupta, Amit, Dascalu, Ana Maria, Musina, Ana-Maria, Bakopoulos, Anargyros, Zakaria, Andee Dzulkarnaen, Vereczkei, Andras, Balla, Andrea, Bottari, Andrea, Baumann, Andreas, Fette, Andreas, Litvin, Andrey, Reichert, Aniella Katharina, Guariniello, Anna, Paspala, Anna, Schneck, Anne-Sophie, Brillantino, Antonio, Pesce, Antonio, Isik, Arda, Leppäniemi, Ari Kalevi, Papadopoulos, Aristeidis, Kechagias, Aristotelis, Mohamed, Ashraf Yehya Abdalla, Mitul, Ashrarur Rahman, Marinis, Athanasios, Syllaios, Athanasios, Mantoglu, Baris, De Simone, Belinda, Weiss, Benjamin Stefan, Pösentrup, Bernd, Picardi, Biagio, Zampogna, Biagio, Sakakushev, Boris Eugeniev, Atanasov, Boyko Chavdarov, Nardo, Bruno, Calik, Bulent, Cremonini, Camilla, Ordoñez, Carlos A., Seretis, Charalampos, Cascone, Chiara, Chouliaras, Christos, Bendinelli, Cino, Lopes, Claudia, Guerci, Claudio, Weber, Clemens, Nastos, Constantinos, Mesina, Cristian, Caputo, Damiano, Massalou, Damien, Cavaliere, Davide, Mcnamara, Deborah A., Demetriades, Demetrios, Pantalone, Desirè, Coletta, Diego, Sasia, Diego, Visconti, Diego, Weber, Dieter G., Corallino, Diletta, Chatzipetris, Dimitrios, Manatakis, Dimitrios K., Ntourakis, Dimitrios, Papaconstantinou, Dimitrios, Schizas, Dimitrios, Chrysikos, Dimosthenis, Adamovich, Dmitry Mikhailovich, Elkafrawy, Doaa, Seban, Dragos, García, Edgar Fernando Hernandez, Baldini, Edoardo, Picetti, Edoardo, Tan, Edward C. T. H., Baili, Efstratia, Lostoridis, Eftychios, Toma, Elena Adelina, Colak, Elif, Cerutti, Elisabetta, Steyn, Elmin, Hsabo, Elmuiz A., Kapetanakis, Emmanouil Ioannis, Kaouras, Emmanouil, Schneck, Emmanuel, Akin, Emrah, Gonullu, Emre, Çelik, Enes, Cicuttin, Enrico, Pinotti, Enrico, Johnsson, Erik, Moore, Ernest E., Agastra, Ervis, Dimitrov, Evgeni Nikolaev, Griffiths, Ewen A., D’Acapito, Fabrizio, Saraceno, Federica, Alconchel, Felipe, Zeppernick, Felix Alexander, Rodríguez, Fernando Machado, Abu-Zidan, Fikri, Pecchini, Francesca, Favi, Francesco, Ferrara, Francesco, Fleres, Francesco, Pata, Francesco, Roscio, Francesco Pietro Maria, Mulita, Francesk, Dor, Frank J. M. F., Linder, Fredrik, Dimofte, Gabriel, Rodrigues, Gabriel, Nita, Gabriela, Sganga, Gabriele, Martines, Gennaro, Mazzarella, Gennaro, Perrone, Gennaro, Velmahos, George, Lianos, Georgios D., Tomadze, Gia, Baiocchi, Gian Luca, D’Ambrosio, Giancarlo, Pellino, Gianluca, Pattacini, Gianmaria Casoni, Giraudo, Giorgio, Lisi, Giorgio, Tebala, Giovanni Domenico, Pirozzolo, Giovanni, Montori, Giulia, Argenio, Giulio, Brisinda, Giuseppe, Currò, Giuseppe, Giuliani, Giuseppe, Palomba, Giuseppe, Roscitano, Giuseppe, Avşar, Gökhan, Augustin, Goran, Clarizia, Guglielmo, Vega, Gustavo M. Machain, Fraga, Gustavo P., Sethi, Harsheet, Eltyeb, Hazim Abdulnassir, Lohse, Helmut A. Segovia, Lohse, Herald René Segovia, Bayhan, Hüseyin, Hamid, Hytham K. S., Kryvoruchko, Igor A., Iannone, Immacolata, Wani, Imtiaz, Lazaridis, Ioannis I., Katsaros, Ioannis, Nikolopoulos, Ioannis, Negoi, Ionut, Reccia, Isabella, Di Carlo, Isidoro, Olaoye, Iyiade Olatunde, Czepiel, Jacek, Kim, Jae Il, Meyer, Jeremy, Terrazas, Jesus Manuel Saenz, Tochie, Joel Noutakdie, Galante, Joseph M., Davies, Justin, Sugand, Kapil, Gonfa, Kebebe Bekele, Rasa, Kemal, Kok, Kenneth Y. Y., Apostolou, Konstantinos G., Lasithiotakis, Konstantinos, Tsekouras, Konstantinos, Angamuthu, Kumar, Akhmeteli, Lali, Sydorchuk, Larysa, Fortuna, Laura, Siragusa, Leandro, Pagani, Leonardo, Solaini, Leonardo, Miller, Lisa A., Bains, Lovenish, Ansaloni, Luca, Ferrario, Luca, Bonavina, Luigi, Conti, Luigi, Buonomo, Luis Antonio, Tallon-Aguilar, Luis, Tomczyk, Lukas, Widmer, Lukas Werner, Walędziak, Maciej, Gachabayov, Mahir, Bulanauca, Maloni M., Malbrain, Manu L. N. G., Maegele, Marc, Catarci, Marco, Ceresoli, Marco, Ranucci, Maria Chiara, Antonopoulou, Maria Ioanna, Papadoliopoulou, Maria, Valenti, Maria Rosaria, Sotiropoulou, Maria, D’Oria, Mario, Martín, Mario Serradilla, Hirschburger, Markus, Veroux, Massimiliano, Fantoni, Massimo, Nardi, Matteo, Tolonen, Matti, Montuori, Mauro, Podda, Mauro, Scheiterle, Maximilian, Frountzas, Maximos, Sarıkaya, Mehmet, Yildirim, Mehmet, Bender, Michael, Vailas, Michail, Teuben, Michel, Campanelli, Michela, Ammendola, Michele, Malerba, Michele, Pisano, Michele, Pertea, Mihaela, Slavchev, Mihail, Ukkonen, Mika, Bala, Miklosh, Chirica, Mircea, Barone, Mirko, Shaat, Mohamed Maher, Mohammed, Mohammed Jibreel Suliman, Abuelgasim, Mona Awad Akasha, Gureh, Monika, Ouadii, Mouaqit, Balkan, Mujdat, Mohamed, Mumin, Hakseven, Musluh, Velenciuc, Natalia, Cillara, Nicola, De’Angelis, Nicola, Tamini, Nicolò, Zavras, Nikolaos J., Machairas, Nikolaos, Michalopoulos, Nikolaos, Koliakos, Nikolaos N., Pararas, Nikolaos, Donlon, Noel E., Medappil, Noushif, Ben-Ishay, Offir, Stefano, Olmi, Islam, Omar, Tammo, Ömer, Ioannidis, Orestis, Aparicio, Oscar, Baraket, Oussama, Kumar, Pankaj, Cianci, Pasquale, Örtenwall, Per, Uchikov, Petar Angelov, de Reuver, Philip, Stahel, Philip F., Barie, Philip S., Piccoli, Micaela, Major, Piotr, Navsaria, Pradeep H., Sasmal, Prakash Kumar, Coimbra, Raul, Rahim, Razrim, Çapoğlu, Recayi, Koshy, Renol M., Gonsaga, Ricardo Alessandro Teixeira, Pertile, Riccardo, Mohamed, Rifat Ramadan Mussa, Deryol, Rıza, Sawyer, Robert G., Angelico, Roberta, Ragozzino, Roberta, Bini, Roberto, Cammarata, Roberto, Scaramuzzo, Rosa, Gioco, Rossella, Sydorchuk, Ruslan, Ahmed, Salma, Di Saverio, Salomone, Emile, Sameh Hany, Delibegovic, Samir, Marwah, Sanjay, Symeonidis, Savvas, Thomas, Scott G., Demir, Sebahattin, Awad, Selmy S., Atici, Semra Demirli, Chooklin, Serge, Meric, Serhat, Sarıkaya, Sevcan, Chowdhury, Sharfuddin, Mirghani, Shaza Faycal, Wren, Sherry M., Gargarella, Simone, Del Monte, Simone Rossi, Esposito, Sofia, Xenaki, Sofia, Mohamed, Soliman Fayez Ghedan, Beka, Solomon Gurmu, Lunca, Sorinel, Delis, Spiros G., Dritsas, Spyridon, Morarasu, Stefan, Magnone, Stefano, Rossi, Stefano, Bitsianis, Stefanos, Kykalos, Stylianos, Baral, Suman, Jain, Sumita A., Ali, Syed Muhammad, Pintar, Tadeja, Triantafyllou, Tania, Delko, Tarik, Perra, Teresa, Sidiropoulos, Theodoros A., Scalea, Thomas M., Vilz, Tim Oliver, Hardcastle, Timothy Craig, Wannatoop, Tongporn, Herzog, Torsten, Mishra, Tushar Subhadarshan, Boggi, Ugo, Calu, Valentin, Tomajer, Valentina, Agnoletti, Vanni, Lohsiriwat, Varut, Kong, Victor, Muñoz-Cruzado, Virginia Durán, Shelat, Vishal G., Khokha, Vladimir, Ghannam, Wagih Mommtaz, Biffl, Walter L., Zuidema, Wietse, Kara, Yasin, Kobe, Yoshiro, Demetrashvili, Zaza, Memish, Ziad A., Madrazo, Zoilo, Balogh, Zsolt J., and Bayhan, Zulfu

Subjects
Emergency Medicine, Surgery
Published
2022

16. The Impact of the COVID-19 Pandemic on Bariatric Surgery: Results from a Worldwide Survey

Author

Lazaridis, Ioannis I., Kraljević, Marko, Schneider, Romano, Klasen, Jennifer M., Schizas, Dimitrios, Peterli, Ralph, Kow, Lilian, Delko, Tarik, Noel, Patrick, Singhal, Rishi, Girodet, Matthieu, Soprani, Antoine, Brehant, Olivier, Moszkowicz, David, Coueffe, Xaviera, Lanne, Jean Sebastien, Rosenblum, Ilan, Moldovanu, Radu, Pflieger, Hannah, Kuperas, Cyrille, Martinez Duartez, Pedro, Luyer, Misha D. P., Arnalsteen, Laurent, Hazebroek, Eric J., Sykora, Martin, Kennedy, Colleen, Hauswirth, Fabian, Tchanderli-Braham, Riad, Le Page, Sébastien, Boerma, Evert-Jan G., Chousleb, Elias, Langenhoff, Barbara, ElFawal, Mohamad Hayssam, Paolino, Luca, Martini, Francesco, Johanet, Hubert, Barthes, Thierry, Halabi, Maen, Del Prete, Marco, Fiolo, Felipe Eduardo, Blanchard, Claire, Bashir, Ahmad, Hagen, Monika, Techagumpuch, Ajjana, Dan, Sebastien, Catheline, Jean-Marc, Georgeac, Constantin, Lefter, Liviu Paul, Lechaux, David, Widmer, Jeannette, Kaijser, Mirjam Anna, Orlowski, Michal, François, Peter, Rogers, Ann M., Nitu, Valentin, Servajean, Stephane, Fishman, Michael, Ignat, Dana Mihaela, Molasoko, Jean Marie, Takkenberg, Marijn, Amal, Ennassih, Charara, Mazen, Parmar, Chetan, Brévart, Christophe, Warberg, Eivind Andreas, Marx, Ludovic, and Vix, Michel

Subjects
Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Original Contributions, Endocrinology, Diabetes and Metabolism, Pneumonia, Viral, 030209 endocrinology & metabolism, Disease, Electronic mail, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Pandemic, medicine, Humans, Upper gastrointestinal, Outpatient clinic, Practice Patterns, Physicians', Survey, Laparoscopy, Pandemics, Bariatric surgery, Nutrition and Dietetics, Routine screening, medicine.diagnostic_test, SARS-CoV-2, business.industry, COVID-19, Middle Aged, Obesity, Morbid, Surgery, Elective Surgical Procedures, IFSO, Female, 030211 gastroenterology & hepatology, Coronavirus Infections, business
Abstract

Background The ongoing “coronavirus disease 19” (COVID-19) pandemic has had a strong effect on the delivery of surgical care worldwide. Elective surgeries have been canceled or delayed in order to reallocate resources to the treatment of COVID-19 patients. Currently, the impact of the COVID-19 pandemic on bariatric and metabolic surgical practice remains unclear. Methods An internet-based online survey was performed among bariatric surgeons worldwide. The survey was sent to bariatric surgeons via the International Bariatric Club Facebook group and by electronic mail via the International Federation for the Surgery of Obesity and metabolic disorders (IFSO) secretariat to members of the associated national IFSO societies. Results One hundred sixty-nine (n = 169) bariatric surgeons participated in the survey. The majority of the respondents postponed preoperative upper gastrointestinal tract endoscopies, appointments in the outpatient clinic and bariatric operations. Most surgeons performed video calls for follow-up appointments instead of meeting the patients in the outpatient clinics. Laparoscopy was still the preferred treatment for surgical emergencies, but a trend towards conservative treatment of acute appendicitis and acute cholecystitis was shown. Rapid preoperative COVID-19 testing availability was poor; therefore, routine screening of emergency bariatric cases was not widely provided. A wide variance occurred regarding precautions and personal protection equipment among the participants. Conclusion The COVID-19 pandemic showed a strong impact on bariatric surgical practice regarding surgical and outpatient planning as well as personnel management. Coordinated effort from the national bariatric societies should focus on strict implementation of the current recommendations regarding precaution measures and personal protection equipment. Further studies should evaluate how this impact will evolve in the near future.

Published
2020

17. The Impact of the COVID-19 Pandemic on Bariatric Surgery: Results from a Worldwide Survey

Author

Lazaridis, Ioannis I, Kraljević, Marko, Schneider, Romano, Klasen, Jennifer M, Schizas, Dimitrios, Peterli, Ralph, Kow, Lilian, Delko, Tarik, Widmer, Jeannette, University of Zurich, and Delko, Tarik

Subjects
Diabetes and Metabolism, 2712 Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, Endocrinology, 2916 Nutrition and Dietetics, 610 Medicine & health, Surgery, 10217 Clinic for Visceral and Transplantation Surgery, 2746 Surgery, COVID
Published
2020

20. Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature.

Author

Schizas, Dimitrios, Katsaros, Ioannis, Mastoraki, Aikaterini, Karela, Nina-Rafailia, Zampetaki, Despoina, Lazaridis, Ioannis I., Tsapralis, Dimitrios, and Theodoropoulos, George E.

Subjects
SQUAMOUS cell carcinoma, RECTUM, COLON (Anatomy), RECTAL cancer, RECTUM tumors, CHEMORADIOTHERAPY
Abstract

Background - Objective: Primary colorectal squamous cell carcinoma is an extremely rare neoplasm with an incidence of 0.1 to 0.25 per 1,000 diagnosed colorectal carcinomas.The objective of this study was to evaluate its biological behavior and highlight the role of a surgical approach for its management. Methods PubMed and Cohrane databases were independently searched (last search: April 10th, 2020) for articles concerning colorectal squamous cell carcinoma in adult population. Results: Seventy-one studies met predefined inclusion criteria and involved 99 patients (54.5% females) with an age of 56.98 ± 12.19 years (mean ± SD). The most frequent site of occurrence was the rectum (63.5%). Open surgery was conducted at 95% of patients, while 21.4% and 30.3% received neoadjuvant and adjuvant therapy respectively.Postoperative complications were developed in 31.3% of patients, while 6.1% died withing the first month following operation. Five-years survival rate was 49.5% (95% CI: 33.7%-63.4%). Female sex (HR: 0.24; 95% CI: 0.11–0.54; p-value: 0.001) and presence of postoperative complications (HR: 4.10; 95%CI: 1.47–1.46; p-value: 0.007) significantly affected the survival. Conclusions Colorectal Squamous Cell Carcinoma is a rare tumor with an aggressive behavior. Surgery is the standard of treatment for the colontumors, while the role of chemoradiotherapy is promising especially for rectal tumors. Further clinical trials are necessary to determine the preferred treatment approach. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb.

Author

Lazaridis II, Bosch AJT, Keller L, Low AJY, Tamarelle J, Moser SO, Winter DV, Gómez C, Peterson CJ, Schneider R, Kraljević M, Odermatt A, Vonaesch P, Peterli R, Delko T, and Cavelti-Weder C

Subjects
Animals, Male, Mice, Diet, High-Fat, Gastrointestinal Microbiome physiology, Anastomosis, Surgical, Obesity, Morbid surgery, Obesity, Morbid metabolism, Bile Acids and Salts metabolism, Gastric Bypass, Mice, Inbred C57BL, Weight Loss physiology, Mice, Obese, Obesity surgery, Obesity metabolism
Abstract

One-anastomosis gastric bypass (OAGB) has gained importance as a simple, safe, and effective operation to treat morbid obesity. We previously found that Roux-en-Y gastric bypass surgery with a long compared with a short biliopancreatic limb (BPL) leads to improved weight loss and glucose tolerance in obese mice. However, it is not known whether a long BPL in OAGB surgery also results in beneficial metabolic outcomes. Five-week-old male C57BL/6J mice fed a high-fat diet (HFD) for 8 weeks underwent OAGB surgery with defined BPL lengths (5.5 cm distally of the duodenojejunal junction for short and 9.5 cm for long BPL), or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut microbiota, and bile acids were assessed. Total weight loss was independent of the length of the BPL after OAGB surgery. However, a long BPL was associated with lower glucose-stimulated insulin on day 14 , and an improved glucose tolerance on day 35 after surgery. Moreover, a long BPL resulted in reduced total cholesterol, while there were no differences in the resolution of metabolic dysfunction-associated steatotic liver disease (MASLD) and adipose tissue inflammation. Tendencies of an attenuated hypothalamic-pituitary-adrenal (HPA) axis and aldosterone were present in the long BPL group. With both the short and long BPL, we found an increase in primary conjugated bile acids (pronounced in long BPL) along with a loss in bacterial Desulfovibrionaceae and Erysipelotrichaceae and simultaneous increase in Akkermansiaceae , Sutterellaceae , and Enterobacteriaceae . In summary, OAGB surgery with a long compared with a short BPL led to similar weight loss, but improved glucose metabolism, lipid, and endocrine outcomes in obese mice, potentially mediated through changes in gut microbiota and related bile acids. Tailoring the BPL length in humans might help to optimize metabolic outcomes after bariatric surgery. NEW & NOTEWORTHY Weight loss following OAGB surgery in obese mice was not influenced by BPL length, but a longer BPL was associated with improved metabolic outcomes, including glucose and lipid homeostasis. These changes could be mediated by bile acids upon altered gut microbiota. Further validation of these findings is required through a randomized human study.

Published
2024
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24. Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.

Author

Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, and Felekouras E

Subjects
Adult, Aged, Disease-Free Survival, Female, Humans, Islets of Langerhans metabolism, Islets of Langerhans pathology, Male, Middle Aged, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local therapy, Pancreatectomy, Pancreatic Neoplasms blood, Pancreatic Neoplasms pathology, Vasoactive Intestinal Peptide blood, Vipoma blood, Vipoma pathology, Vipoma therapy, Neoplasm Recurrence, Local surgery, Pancreatic Neoplasms surgery, Vasoactive Intestinal Peptide biosynthesis, Vipoma surgery
Abstract

Purpose: Vasoactive intestinal peptide (VIP) secreting tumor (VIPoma) constitutes a rare functional neuroendocrine tumor that most often originates from pancreatic islet cells and presents as a sporadic, solitary neoplasm of the pancreas. The purpose of this study was to systematically review the literature of pancreatic VIPomas and report clinicopathologic data and treatment modalities for this rare entity., Methods: A systematic literature search was performed. The reviewed clinical series and case reports were included if they reported surgical treatment and also analyzed oncological outcomes on individual patients. Data extraction was performed using a standard registry pro-forma., Results: The search resulted in 53 case reports and 2 case series including 65 patients in total. Median age reported was 54 years. The predominant pancreatic location was the pancreatic tail. The most common clinical symptom was watery diarrhea. Serum VIP levels were remarkably elevated in all patients. Distal pancreatectomy with or without splenectomy was the most commonly applied surgical procedure. Overall survival associated with pancreatic VIPoma was 67.7%, recurrence rate 40.4% and relevant median disease-free interval was 16 months., Conclusions: VIPomas are functional tumors that secrete excessive amounts of VIP. Clinically, production of VIP causes refractory watery diarrhea, hypokalemia and achlorydria. As far as diagnosis is concerned, elevated VIP plasma levels are required. Moreover, the majority of VIPomas are malignant or have already metastasized on diagnosis. Despite recent research on the therapeutic strategies against pancreatic VIPoma, surgical resection appears as the only potentially curative approach.

Published
2019

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