135 results on '"Lazarou, L."'
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2. Patient positioning during percutaneous nephrolithotomy: what is the current best practice?
- Author
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Mourmouris P, Berdempes M, Markopoulos T, Lazarou L, Tzelves L, and Skolarikos A
- Subjects
percutaneous nephrolithotomy ,prone ,supine ,complications ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Panagiotis Mourmouris, Marinos Berdempes, Titos Markopoulos, Lazaros Lazarou, Lazaros Tzelves, Andreas Skolarikos Second Department of Urology, Athens Medical School, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece Abstract: Percutaneous nephrolithotomy (PCNL) is the gold standard procedure for treatment of large stones and complex kidney disorders, but its morbidity remains the highest among stone treatment procedures. In pursuit of minimizing complication rates, surgeons have developed different variations of the classic prone position in which PCNL is usually performed; one among them is supine position. In this study, we review the literature and present all available evidence on different variations in positioning during PCNL, in an effort to identify if there is a position that can minimize the morbidity of this procedure. Keywords: percutaneous nephrolithotomy, prone, supine, complications
- Published
- 2018
3. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
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Dennis, Rory, Scaramuzzo, Rosa, Macías, Rosa Montero, Sánchez, Rosa, Ogu, Rosemary, Ramely, Rosnelifaizur, Sgarzani, Rossella, Ramli, Roszalina, Hillier, Roxane, Thumbadoo, Ruben, Ooi, Rucira, Abdus-Salam, Rukiyat, Masri, Ruqaya, Hodgson, Russell, Mathew, Ryan, Wade, Ryckie, D'archi, Sabatino, Khan, Sabina, Ngaserin, Sabrina, Kale, Sachin, Hassan, Sadiq, Merghani, Safa, Benamar, Safia, Muhammad, Sagir, Badran, Saif, Elsahli, Saifaleslam, Heta, Saimir, Hammouche, Salah, Baeesa, Saleh, Paiella, Salvatore, Eldeen, Samaher Taj Eldeen Hassan Taj, Arkani, Samara, Mittal, Samarth, Hirji, Sameer, Tebha, Sameer, Emile, Sameh, Dbouk, Samer, Bandyopadhyay, Samik Kumar, Muhammad, Saminu, Olori, Samson, Asirifi, Samuel Amoako, Hailu, Samuel, Ling, Samuel, Newman, Samuel, Ross, Samuel, Wanjara, Samuel, Kumar, Sandip, Seneviratne, Sanjeewa, Tamburello, Sara, Suarez, Sara Busto, Ingallinella, Sara, Irshaidat, Sara, Konswa, Sara, Mambrilla, Sara, Nasser, Sara, Parini, Sara, Pitoni, Sara, Ornaghi, Sara, 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Mayo-Yáñez, Miguel, Melo, Miguel Rocha, Ruiz-Marín, Miguel, Eiras, Miguel Angel Freiria, Cunha, Miguel F, Pertea, Mihaela, Slavchev, Mihail, Davidescu, Mihnea, Prieto, Mikel, Agapov, Mikhail, Gahwagi, Milad, Prats, Milagros Carrasco, Rudic, Milan, Verbic, Milena Senica, Kostusiak, Milosz, Stoleriu, Mircea Gabriel, Lucas, Miriam Abellan, Barone, Mirko, Ahmad, Misbahu, Alemu, Misganaw Alemu Adimass, Fatima, Mishal, Ida, Mitsuru, Sahu, Mo, Muhaisen, Mo'nes, Salem, Moacyr, Emara, Moataz Maher, Oludara, Mobolaji, Sotudeh, Mohadeseh, Kassab, Mohamad B, Abdelkhalek, Mohamed, Alsori, Mohamed, Anwar, Mohamed, El-Kassas, Mohamed, Elbahnasawy, Mohamed, Eldabaa, Mohamed, Rabie, Mohamed, Hassanin, Mohamed Abdelghafor, Thaha, Mohamed Adhnan, Ali, Mohamed Shafi Mahboob, Alhamid, Mohammad, Almoshantaf, Mohammad Badr, Keramati, Mohammad Reza, Bafaquh, Mohammed, Abuzaid, Mohammed, Al-Shehari, Mohammed, Alharthi, Mohammed, Alkahlan, Mohammed, Alwash, Mohammed, Alyousef, Mohammed, Amir, Mohammed, 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Pazmiño, Patricio Andrés Freile, Coughlin, Patrick, Kirchweger, Patrick, Pessaux, Patrick, Maguire, Patrick J, Petrone, Patrizio, Cullis, Paul, Köglberger, Paul, Marriott, Paul, Nankivell, Paul, Santos-Costa, Paulo, Martins, Paulo N, Panahi, Pedram, Botelho, Pedro, Teixeira, Pedro, Escobar, Pedro, Vázquez, Pedro José Gil, Gribnev, Petar, Nolte, Peter, Agbonrofo, Peter, Bobak, Peter, Choong, Peter, Elbe, Peter, Hutchinson, Peter, Labib, Peter, Paal, Peter, Pockney, Peter, Reemst, Peter, Szatmary, Peter, Vaughan-Shaw, Peter G, Alexander, Philip, Pucher, Philip, Stather, Philip, Foessleitner, Philipp, Winnand, Philipp, Zehnder, Philipp, Kruse, Philippe, Matos, Philomena Alice Wawer, Lapolla, Pierfrancesco, Cicerchia, Pierfranco Maria, Solli, Piergiorgio, Di Lascio, Pierpaolo, Zarif, Pierre, Champagne, Pierre-Olivier, Anoldo, Pietro, Bertoglio, Pietro, Fransvea, Pietro, Familiari, Pietro, Lombardi, Pietro Maria, Stogowski, Piotr Tomasz, Bruzzaniti, Placido, Tripathi, Prashant, D'sa, 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Beron, Reinaldo Isaacs, Függer, Reinhold, Othman, Rema, Saad, Rema, Amores, Remedios Revilla, Colombari, Renan Carlo, Radivojević, Renata Curic, Patrone, Renato, Novysedlák, René, Huatuco, René Manuel Palacios, Baertschiger, Reto, Liang, Rhea, Luckwell, Rhys, Escrevente, Ricardo, Rezende, Ricardo Fernandes, Cruz, Ricardo Pedrini, Lenzi, Riccardo, Rosati, Riccardo, Donovan, Richard, Egan, Richard, Morris, Richard, Page, Richard, Seglenieks, Richard, Unsworth, Richard, Wilkin, Richard, Skipworth, Richard Je, Davies, Richard Justin, Bezirci, Rifat, Talwar, Rishi, Azami, Rizwan, Bohmer, Rob, Crichton, Robert, Fruscio, Robert, Hooker, Robert, Jach, Robert, Parker, Robert, Pillerstorff, Robert, Sinnerton, Robert, Stabler, Robert, O'connell, Robert Michael, Ragozzino, Roberta, Tutino, Roberta, Angelico, Roberta, Cammarata, Roberto, Colasanti, Roberto, Macchiavello, Roberto, Peltrini, Roberto, Pirrello, Roberto, Vaschetti, Roberto, Pires, Robinson Esteves, Papalia, Rocco, Arrangoiz, Rodrigo, 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Sara, Konswa, Sara, Mambrilla, Sara, Nasser, Sara, Parini, Sara, Pitoni, Sara, Ornaghi, Sara, Rodrigues, Sara Castanheira, Abdelmohsen, Sarah, Aitken, Sarah, Tian, Sarah, Badiani, Sarit, Ahmad, Sarwat, Swed, Sarya, Muthu, Sathish, Lakpriya, Sathya, Alzahrani, Saud, Mikalauskas, Saulius, Lasrado, Savita, Satoskar, Savni, Bawa, Sayesha, Altiner, Saygin, Garcia, Sean, Stevens, Sean, Demir, Sebahattin, Ken-Amoah, Sebastian, Tranca, Sebastian, Ziemann, Sebastian, Awad, Selmy, Atici, Semra Demirli, Subramaniam, Sentilnathan, Erel, Serap, Jiang, Serena, Efetov, Sergey, Efremov, Sergey, Katorkin, Sergey, Valladares, Sergio Chávez, Contreras, Sergio Marcos, Meriç, Serhat, Zenger, Serkan, Safi, Seyer, Leventoğlu, Sezai, Elsalhawy, Shady, Shaikh, Shafaque, Sheik, Shahila, Islam, Shahnoor, Shamim, Shahzad, Waqar, Shahzad Hussain, Ahmad, Shahzaib, Farid, Shahzaib, Seraj, Shaikh Sanjid, Sundarraju, Shalini, Karandikar, Sharad, Sambhwani, Sharan, Chopra, Sharat, Chowdhury, Sharfuddin, Laura, Sharon, 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Safranovs, Toms Janis, Risteski, Toni, Pang, Tony, Akinyemi, Tosin, Yotsov, Tsanko, Laeke, Tsegazeab, Kochiyama, Tsukasa, Sholadoye, Tunde T, Alekberli, Tural, Ezomike, Uchechukwu, Giustizieri, Ugo, Grossi, Ugo, Köksoy, Ülkü Ceren, Bork, Ulrich, Kisser, Ulrich, Ronellenfitsch, Ulrich, Saeed, Umar, Bracale, Umberto, Jayarajah, Umesh, Rauf, Umme Habiba Abdul, Bumbasirevic, Uros, Ferrer, Ursula María Jariod, Ahmed, Usama, Bello, Usman Mohammed, Jogiat, Uzair, Sadia, Uzma, Galandarov, Vagif, Narayanan, Vairavan, Calu, Valentin, Bianchi, Valentina, Ciniero, Valeria, Tonini, Valeria, Silvestri, Vania, Vijay, Vardhini, Dewan, Varun, Lohsiriwat, Varut, Thuduvage, Vasanthika, Mousafeiris, Vasileios, Dragisic, Vedran, Sasireka, Veerasamy, Santric, Veljko, Kusuma, Venkata Ramana Murthy, Kolli, Venkata Satish, Alonso, Veronica, De Simone, Veronica, Picotti, Veronica, Martínez, Verónica Martín, Panduro-Correa, Vicky, Kakotkin, Victor, Angulo, Victor Pinto, Turrado-Rodriguez, Victor, Krishnamoorthy, Vijay, Ban, Vin Shen, Shah, Vinay, Maiola, Vincenza, Giordano, Vincenzo, La Vaccara, Vincenzo, Lizzi, Vincenzo, Papagni, Vincenzo, Schiavone, Vincenzo, Satchithanantham, Vinojan, Garcia-Virto, Virginia, Jimenez, Virginia, Kumar, Vishal, Shelat, Vishal, Bhat, Vivek, Sodhai, Vivek, Graziadei, Vivien, Kutuzov, Vladislav, Stoyanov, Vladislav, Oktseloglou, Vlasios, Flis, Vojko, Elhassan, Wael Atif Fadl, Yang, Wah, Soon, Wai Cheong, Tashkandi, Wail, Al-Khyatt, Waleed, Mabood, Waleed, Bijou, Walid, Wijenayake, Wasantha, D, Wasim, Krawczyk, Wiktor, Atkins, William, Bolton, William, White, William, Ceelen, Wim, Vagena, Xanthoula, Gozal, Yaacov, Baba, Yabasin Iddrisu, Subramani, Yamini, Jansen, Yanina, Mittal, Yash, Kara, Yasi̇n, Zwain, Yasir, Noureldin, Yasser, Alawneh, Yazan, Aydin, Yener, Lam, Yick Ho, Tang, Yita, Lim, Yizhe, Dean, Yomna, Tanas, Yousef, Su, Yu-Xiong, Fujimoto, Yuki, Altinel, Yuksel, Frolova, Yulia, Oshodi, Yusuf, Fadel, Zahir T, Zahid, Zahra, Elahi, Zain, Djama, Zakarya, Zaheen, Zakia, Jawad, Zaynab, Demetrashvili, Zaza, Gebremeskel, Zersenay, Gudisa, Zewdie, Alyami, Ziyad, Garoufalia, Zoe, Li, Zoe, Zimak, Zoran, Radin, Zorana, and Balogh, Zsolt J
- Abstract
Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was coprioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.
- Published
- 2023
4. Familial Hypercholesterolaemia – a targeted Next Generation Sequencing panel and retrospective analysis of patients with no previously identified pathogenic variant
- Author
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Willis, E., primary, Wood, M., additional, Hamling, N., additional, Lazarou, L., additional, Morgan, S., additional, Corrin, S., additional, Harris, R., additional, McDowell, I., additional, Haralambos, K., additional, and Datta, D., additional
- Published
- 2022
- Full Text
- View/download PDF
5. Gastroenteropancreatic neuroendocrine tumour presenting as complete large bowel obstruction: Literature review seizing upon a case
- Author
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Bouras, Panagiotis, Kostopoulos, G., Liori, A., Vlastarakos, P., Lazarou, L., Kentarxos, I., Karathanasi, A.M., Douitsis, E., Nikas, K., Gallias, S., Christodoulou, K., and Gatsoulis, N.
- Published
- 2015
- Full Text
- View/download PDF
6. Using machine learning techniques to predict antimicrobial resistance in stone disease patients
- Author
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Tzelves, L. Lazarou, L. Feretzakis, G. Kalles, D. Mourmouris, P. Loupelis, E. Basourakos, S. Berdempes, M. Manolitsis, I. Mitsogiannis, I. Skolarikos, A. Varkarakis, I.
- Abstract
Purpose: Artificial intelligence is part of our daily life and machine learning techniques offer possibilities unknown until now in medicine. This study aims to offer an evaluation of the performance of machine learning (ML) techniques, for predicting bacterial resistance in a urology department. Methods: Data were retrieved from laboratory information system (LIS) concerning 239 patients with urolithiasis hospitalized in the urology department of a tertiary hospital over a 1-year period (2019): age, gender, Gram stain (positive, negative), bacterial species, sample type, antibiotics and antimicrobial susceptibility. In our experiments, we compared several classifiers following a tenfold cross-validation approach on 2 different versions of our dataset; the first contained only information of Gram stain, while the second had knowledge of bacterial species. Results: The best results in the balanced dataset containing Gram stain, achieve a weighted average receiver operator curve (ROC) area of 0.768 and F-measure of 0.708, using a multinomial logistic regression model with a ridge estimator. The corresponding results of the balanced dataset, that contained bacterial species, achieve a weighted average ROC area of 0.874 and F-measure of 0.783, with a bagging classifier. Conclusions: Artificial intelligence technology can be used for making predictions on antibiotic resistance patterns when knowing Gram staining with an accuracy of 77% and nearly 87% when identifying specific microorganisms. This knowledge can aid urologists prescribing the appropriate antibiotic 24–48 h before test results are known. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Published
- 2022
7. Formación de la residencia de Urología en Grecia. Resultados de la primera encuesta nacional
- Author
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Tzelves, L., primary, Glykas, I., additional, Lazarou, L., additional, Zabaftis, C., additional, Fragkoulis, C., additional, Leventi, A., additional, Moulavasilis, N., additional, Tzavellas, D., additional, Tsirkas, K., additional, Ntoumas, K., additional, Mourmouris, P., additional, Dellis, A., additional, Varkarakis, I., additional, Skolarikos, A., additional, Liatsikos, E., additional, and Gkialas, I., additional
- Published
- 2021
- Full Text
- View/download PDF
8. The laboratory mouse and wild immunology
- Author
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Viney, M., Lazarou, L., and Abolins, S.
- Published
- 2015
- Full Text
- View/download PDF
9. Defining the ideal urology training programme from the trainee’s and professor’s perspective: Is there a concordance in their idea of good training?
- Author
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Mantica, G., primary, Carrion, D.M., additional, Pang, K.H., additional, Ucar, T., additional, Parodi, S., additional, Tappero, S., additional, Lazarou, L., additional, Glykas, I., additional, Zambaftis, C., additional, Lourenco, M., additional, Gonzalez Padilla, D.A., additional, Ortega Polledo, L.E., additional, Gomez Rivas, J., additional, and Esperto, F., additional
- Published
- 2021
- Full Text
- View/download PDF
10. An up-to-date evaluation of darolutamide for the treatment of prostate cancer
- Author
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Moussa, M. Lazarou, L. Dellis, A. Abou Chakra, M. Papatsoris, A.
- Abstract
Introduction: Currently, in prostate cancer, an increasing number of novel drugs are being used to delay its advancement to metastatic castration-resistant prostate cancer (mCRPC). Apalutamide, enzalutamide, and most recently, darolutamide (novel androgen receptor antagonists) have been approved for nonmetastatic castration-resistant prostate cancer (nmCRPC). Areas covered: The authors have evaluated darolutamide, covering all aspects of the clinical development, competence, and safety profile of the drug. Expert opinion: The unique structure of darolutamide is characterized by a high affinity for androgen receptors and detainment of antagonist activity in mutant isoforms of androgen receptors. In clinical practice, this is the main reason that makes darolutamide exceptional in terms of safety and efficacy compared to other drugs in this category. Darolutamide is considered to have the lowest probability for adverse events (AEs) compared to apalutamide and enzalutamide. Future studies, along with real-world clinical data are warranted to improve personalized treatment strategies as well as sequencing treatment between approved novel drugs. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
- Published
- 2021
11. Fragility index of urological literature regarding medical expulsive treatment
- Author
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Tzelves, L. Chatzikrachtis, N. Lazarou, L. Mourmouris, P. Pinitas, A. Tsirkas, K. Petropoulos, O. Berdempes, M. Feretzakis, G. Glykas, I. Fragkoulis, C. Varkarakis, I. Skolarikos, A.
- Abstract
Introduction: The role of medical expulsive treatment (MET) is controversial. Fragility index is an additional metric to assess randomized controlled trials (RCTs) outcome validity and indicates how many patients would be required to convert a trial from being statistically significant, to not significant. The larger is the FI, the better the trial’s data. The aim of this study is to assess FI of RCTs regarding MET for ureteral stones. Materials and methods: A systematic literature search was performed. RCTs, reporting stone expulsion as a dichotomous outcome, showing statistical significance were eligible. FI (the number of patients needed to change from a non-event to event group, to lose statistical significance) and Fragility quotient (FI divided by total sample size), were calculated while Pearson’s correlation and Mann–Whitney U test were used as appropriate. Results: Thirty-six RCTs were eligible, with median FI = 3.5 and fragility quotient = 0.042, median sample size = 81, median journal impact factor = 1.73 and median reported p value = 0.008. In 33.3% of the studies, number of patients lost during follow-up was larger than FI, while in 13.89% of the studies, FI was 0, indicating use of inappropriate statistical method. Pearson’s correlation showed significant positive association between FI and sample size (r = 0.981), number of events (r = 0.982) and impact factor (r = 0.731), while no association was found with p value or publication year. Conclusions: In this analysis, a calculated FI of 3.5 indicates that findings from RCTs on MET for ureteral stones are fragile and should be interpreted in combination with clinical thinking and expertise. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Published
- 2021
12. Transdiaphragmatic nephrectomy with synchronous pulmonary and anterior thoracic wall mass metastasectomy in a young male with metastatic renal cell carcinoma; A single-incision approach
- Author
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Lazarou, L. Berdempes, M. Peninta, A. Mitselou, M. Skolarikos, A. Lioulias, A.
- Abstract
Renal cell carcinoma represents approximately 3% of all cancers, with the highest incidence occurring in the western world. Around 33% of the patients experience metastatic disease at diagnosis. Since the approval of the first targeted therapy, the treatment of metastatic renal cell carcinoma (mRCC) has positively changed, but the surgical treatment of the primary tumor, and metastases if possible, is sometimes crucial in selected patients controlling the burden of cancer sites with the intention to improve survival. We, herein, report on a case of a young male patient presented in the emergency room with gross hematuria which underwent transdiaphragmatic nephrectomy with synchronous pulmonary and anterior thoracic wall mass metastasectomy with a single thoracic incision due to mRCC. Achieving a full response in patients with mRCC is extremely rare only with medical treatment. The role of complete surgical metastasectomy is questioned, but there are several studies that support its efficacy in achieving metastases free status prolonged overall survival and better quality of life. The therapeutic treatment plan for these patients should be discussed within dedicated multidisciplinary cancer centers and focus on each patient individually and they should be offered a closed follow-up strategy. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.
- Published
- 2021
13. Urology residency training in Greece. Results from the first national resident survey
- Author
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Tzelves, L. Glykas, I Lazarou, L. Zabaftis, C. and Fragkoulis, C. Leventi, A. Moulavasilis, N. Tzavellas, D. and Tsirkas, K. Ntoumas, K. Mourmouris, P. Dellis, A. and Varkarakis, I Skolarikos, A. Liatsikos, E. Gkialas, I
- Abstract
Background and objectives: This is the first national survey assessing Greek Urology residency programs. The main objective of this study is to assess the level of confidence and perception of Greek Urology residents regarding their educational program and detect areas of improvement. Material and methods: A 51-question survey was developed via an electronic platform and answered by 91 out of 104 Greek residents from March 2019 until May 2019. Fisher’s exact test, chi-squared test and Kruskal-Wallis test were used with statistical significance set at p=.05. Results: The median overall satisfaction regarding surgical training was 6/10 regardless of working schedule, working in a University Department, PGY or number of residents in clinic. Most residents have not performed any scrotal ultrasound or pressure-flow-studies; however, they are more familiar with KUB ultrasound. Double-J stent insertion and cystoscopy were common procedures for residents. Bureaucracy was reported as a major issue by 70.4% of residents. ESWL has not been performed by 80.2% of residents, 58.2% residents performed less than 10 ureteroscopies, and only the last year trainees performed more than 10 TURBT and TURP. Most residents mentioned to rarely perform basic steps in many open or laparoscopic urological procedures. Surprisingly, 59.3% of residents have not published any study in peer-reviewed journals. Regarding satisfaction, 44% rarely feel satisfied at work and 59.3% sometimes suffer from burnout. Response rate reached 87.5%. Conclusions: Considering the results from this survey, regulatory authorities should join forces to establish a structured curriculum of clinical, surgical and research training in Urology across Europe. (C) 2021 AEU. Published by Elsevier Espana, S.L.U. ALL rights reserved.
- Published
- 2021
14. Editorial comment: Does the use of a robot decrease the complication rate adherent to radical cystectomy? A systematic review and meta-analysis of studies comparing open with robotic counterparts
- Author
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Tzelves, L. Skolarikos, A. Mourmouris, P. Lazarou, L. Kostakopoulos, N. Manatakis, D.K. Kural, A.R. Faria, E.F.
- Published
- 2020
15. Renal Hematomas after Ureterolithotripsy: Report of Four Cases
- Author
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Mitsogiannis, I.C. Kostakopoulos, N.A. Lazarou, L. Deliveliotis, K. Karagiotis, T. Deliveliotis, C.
- Abstract
Background: Renal hematomas, although relatively rare, are potentially life-threatening complications after ureterolithotripsy. Case Presentation: We present four cases of renal hematomas that occurred in our department during the past decade (2008-2018). Unstable vital signs, increased inflammatory markers, fever, and flank pain were the commonest postoperative findings. Two patients were treated conservatively and had an uneventful recovery, whereas one patient underwent selective arterial embolization for bleeding control. The fourth patient was diagnosed with contralateral ureteral urothelial tumor and ultimately underwent contralateral radical nephroureterectomy. Conclusion: Application of safety measures during ureteroscopy may reduce the incidence of perirenal hematomas. Prompt diagnosis is based on a thorough clinical examination in combination with imaging to evaluate the location and extent of the hematoma. © Copyright 2020, Mary Ann Liebert, Inc., publishers.
- Published
- 2020
16. High frequency of genomic deletions—and a duplication—in the LIS1 gene in lissencephaly: implications for molecular diagnosis
- Author
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Mei, D, Lewis, R, Parrini, E, Lazarou, L P, Marini, C, Pilz, D T, and Guerrini, R
- Published
- 2008
- Full Text
- View/download PDF
17. A case of cavernosal abscess after neglected penile fracture and bacteremia
- Author
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Lazarou, L. Berdempes, M. Markopoulos, T. Kostakopoulos, N. Spyropoulos, K. Mitsogiannis, I.C.
- Abstract
Penile abscess is a urological entity rarely described in the literature. It has been associated with injection therapy for erectile dysfunction, penile instrumentation, trauma and priapism. Identified risk factors include immunosuppresion and pre-existing local or distant infection. Common causal microorganisms include Staphylococcus aureus, Streptococci and Bacteroides. We herein report on a case of penile abscess in a 37-year-old patient occurring after sexual trauma and presenting with bacteremia. © 2019 Medknow Publications. All rights reserved.
- Published
- 2019
18. Letter to the Editor RE: Venkatramani and Parekh, Editorial Comment on: Does the Use of a Robot Decrease the Complication Rate Adherent to Radical Cystectomy? A Systematic Review and Meta-Analysis of Studies Comparing Open with Robotic Counterparts by Tzelves et al. (From: Tzelves L, Skolarikos A, Mourmouris P, et al. J Endourol 2019;33:985; DOI: 10.1089/end.2019.0689)
- Author
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Tzelves, L. Skolarikos, A. Mourmouris, P. Lazarou, L. Kostakopoulos, N. Manatakis, D.K. Kural, A.R.
- Published
- 2019
19. Gross rearrangements of the MECP2 gene are found in both classical and atypical Rett syndrome patients
- Author
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Archer, H L, Whatley, S D, Evans, J C, Ravine, D, Huppke, P, Kerr, A, Bunyan, D, Kerr, B, Sweeney, E, Davies, S J, Reardon, W, Horn, J, MacDermot, K D, Smith, R A, Magee, A, Donaldson, A, Crow, Y, Hermon, G, Miedzybrodzka, Z, Cooper, D N, Lazarou, L, Butler, R, Sampson, J, Pilz, D T, Laccone, F, and Clarke, A J
- Published
- 2006
20. Patient positioning during percutaneous nephrolithotomy: What is the current best practice?
- Author
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Mourmouris, P. Berdempes, M. Markopoulos, T. Lazarou, L. Tzelves, L. Skolarikos, A.
- Subjects
mental disorders - Abstract
Percutaneous nephrolithotomy (PCNL) is the gold standard procedure for treatment of large stones and complex kidney disorders, but its morbidity remains the highest among stone treatment procedures. In pursuit of minimizing complication rates, surgeons have developed different variations of the classic prone position in which PCNL is usually performed; one among them is supine position. In this study, we review the literature and present all available evidence on different variations in positioning during PCNL, in an effort to identify if there is a position that can minimize the morbidity of this procedure. © 2018 Mourmouris et al.
- Published
- 2018
21. Techniques for fluoroscopic access in PNL: An ESUT educational video
- Author
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Berdempes, M., primary, Kyriazis, I., additional, Lazarou, L., additional, Markopoulos, T., additional, Kallidonis, P., additional, Liatsikos, E., additional, and Skolarikos, A., additional
- Published
- 2019
- Full Text
- View/download PDF
22. Molecular analysis and clinical correlations of the Huntington's disease mutation
- Author
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MacMillan, J C, Snell, R G, Tyler, A, Houlihan, G D, Fenton, I, Cheadle, J P, Lazarou, L P, Shaw, J D, and Harper, P S.
- Published
- 1993
23. Urodynamic assessment of orthotopic neobladder reconstruction following radical cystectomy in bladder cancer
- Author
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Kostakopoulos, N., primary, Argiropoulos, V., additional, Tsirkas, K., additional, Spiropoulos, K., additional, Lazarou, L., additional, Varkarakis, I., additional, and Skolarikos, A., additional
- Published
- 2018
- Full Text
- View/download PDF
24. Huntington's disease intermediate allele and new variant CJD
- Author
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Harper, P.S., Evans, R., Elliston, L., Ironside, J.W., Jones, A.L., and Lazarou, L.
- Subjects
Human genetics -- Research ,Huntington's chorea -- Physiological aspects ,Nervous system -- Degeneration ,Biological sciences - Published
- 2001
25. V35 - Techniques for fluoroscopic access in PNL: An ESUT educational video
- Author
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Berdempes, M., Kyriazis, I., Lazarou, L., Markopoulos, T., Kallidonis, P., Liatsikos, E., and Skolarikos, A.
- Published
- 2019
- Full Text
- View/download PDF
26. Gene symbol: PKD1 Disease: Polycystic kidney disease
- Author
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Daniells, C., Maheshwar, M., Lazarou, L., Davies, F., Coles, G., and Ravine, D.
- Published
- 1998
- Full Text
- View/download PDF
27. Extraperitoneal laparoscopic radical prostatectomy: Our preliminary experience
- Author
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Zougkas, K., primary, Kotakidis, G., additional, Petas, A., additional, Lazarou, L., additional, Marantidis, K., additional, and Christodoulou, N., additional
- Published
- 2016
- Full Text
- View/download PDF
28. Mutations for the autosomal recessive and autosomal dominant forms of polycystic kidney disease are not allelic
- Author
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Ramsay, Michèle, Reeders, Stephen T., Thomson, Peter D., Milner, Lawrence S., Lazarou, L., Barratt, Thomas M., Yau, Adrian, Lehmann, Ordan J., and Jenkins, Trefor
- Published
- 1988
- Full Text
- View/download PDF
29. 06 - Extraperitoneal laparoscopic radical prostatectomy: Our preliminary experience
- Author
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Zougkas, K., Kotakidis, G., Petas, A., Lazarou, L., Marantidis, K., and Christodoulou, N.
- Published
- 2016
- Full Text
- View/download PDF
30. Diagnostik und Therapie eines riesigen, eine Lebercyste imitierenden, retroperitonealen Tumors mit komplexer Binnenstruktur
- Author
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Pieper, FA, primary, Lazarou, L, additional, Kulaksiz, H, additional, and Henne-Bruns, D, additional
- Published
- 2009
- Full Text
- View/download PDF
31. Problems in genetic prediction for Huntington's disease
- Author
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Morris, Michael J., Tyler, Audrey, Lazarou, L., Meredith, Linda, and Harper, P.S.
- Subjects
Genetic screening -- Evaluation ,Huntington's chorea -- Diagnosis ,Medical genetics -- Methods - Published
- 1989
32. Huntington's disease: predictive testing and the molecular genetics laboratory
- Author
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Lazarou, L. P., primary, Meredith, A. L., additional, Myring, J. M., additional, Tyler, A., additional, Morris, M., additional, Ball, O. M., additional, and Harper, P. S., additional
- Published
- 1993
- Full Text
- View/download PDF
33. Five years experience of predictive testing for myotonic dystrophy using linked DNA markers
- Author
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Reardon, W., primary, Floyd, J. L., additional, Myring, J., additional, Lazarou, L. P., additional, Meredith, A. L., additional, and Harper, P. S., additional
- Published
- 1992
- Full Text
- View/download PDF
34. Effects of Intensity of Transcutaneous Electrical Nerve Stimulation (TENS) on Pressure Pain Threshold and Blood Pressure in Healthy Humans: A Randomized, Double-blind, Placebo-controlled Trial.
- Author
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Lazarou L, Kitsios A, Lazarou I, Sikaras E, and Trampas A
- Published
- 2009
- Full Text
- View/download PDF
35. Exclusion testing in pregnancy for Huntington's disease.
- Author
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Tyler, A, primary, Quarrell, O W, additional, Lazarou, L P, additional, Meredith, A L, additional, and Harper, P S, additional
- Published
- 1990
- Full Text
- View/download PDF
36. Presymptomatic testing for Huntington's disease in Wales 1987-90.
- Author
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Tyler, Audrey, Morris, Michael, Lazarou, Lazarus, Meredith, Linda, Myring, Jennifer, Harper, Peter, Tyler, A, Morris, M, Lazarou, L, Meredith, L, Myring, J, and Harper, P
- Subjects
HUNTINGTON'S chorea diagnosis ,SYMPTOMS ,COUNSELING ,CHOREA ,GENETIC disorders ,PSYCHIATRY - Abstract
Between 1987 and 1990 a large series of at-risk individuals has been referred to our Huntington's disease (HD) presymptomatic testing programme. A detailed protocol for assessment and counselling has been followed. Out of 238 serious inquiries, 36% were potentially suitable for the testing programme, but 19% chose not to continue. Reasons for exclusion included the presence of clinical features of HD and being under the age of 18 years. Out of 40 final results given to 38 individuals, 23 indicated a lowered risk, 11 an increased risk, while five results were uninformative, two of these becoming informative on repeat testing. This series contained more women than men, and was disproportionately from the higher socio-economic groups. Motives for requesting a test principally related to child-bearing, informing existing children, and planning for the future. No significant psychiatric symptoms have been reported in the short term, but difficult counselling problems were presented by the high proportion of applicants who already showed clinical signs of HD. It is concluded that a detailed counselling protocol is essential in testing for HD, as many applicants are ill-prepared; this will assume even greater importance when the HD gene is identified and a test for specific mutations is available. The experience of presymptomatic testing for HD provides important general lessons which are likely to be applicable to other inherited neurological and psychiatric disorders. [ABSTRACT FROM AUTHOR]
- Published
- 1992
- Full Text
- View/download PDF
37. Kinetic Study of the Iron(II)- Induced Perbromate-Lactic Acid Reaction with a Perbromate Electrode. Determination of Lactic Acid.
- Author
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Lazarou, L. A. and Hadjiioannou, T. P.
- Published
- 1979
- Full Text
- View/download PDF
38. Construction of a New Perbromate-Selective Electrode. Kinetic Study of the Iron(II)- Perbromate Reaction and Microdetermination of Iron.
- Author
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Lazarou, L. A. and Hadjiioannou, T. P.
- Published
- 1978
- Full Text
- View/download PDF
39. Adult polycystic kidney disease and linked RFLPs at the alpha globin locus: a genetic study in the South Wales population.
- Author
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Lazarou, L P, Davies, F, Sarfarazi, M, Coles, G A, and Harper, P S
- Abstract
Thirteen South Wales kindreds with adult polycystic kidney disease have been studied for genetic linkage using the alpha globin and 3'HVR probes. A maximum lod score of 24.187 was found at a recombination fraction of 0.03. This study supports the existence of a single locus on chromosome 16 responsible for the disorder. [ABSTRACT FROM PUBLISHER]
- Published
- 1987
40. Characterization of 34 novel and six known MTM1 gene mutations in 47 unrelated X-linked myotubular myopathy patients
- Author
-
Tanner, S. M., Schneider, V., Thomas, N. S. T., Clarke, A., Lazarou, L., and Liechti-Gallati, S.
- Published
- 1999
- Full Text
- View/download PDF
41. RFLP for the human erb-A beta locus
- Author
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Wyllie, F S, Lazarou, L P, and Wynford-Thomas, D
- Subjects
Genetic Markers ,Polymorphism, Genetic ,Receptors, Thyroid Hormone ,Proto-Oncogene Proteins ,Humans ,Chromosomes, Human, Pair 3 ,Polymorphism, Restriction Fragment Length - Published
- 1988
42. Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.
- Author
-
Snell, R G, Lazarou, L P, Youngman, S, Quarrell, O W, Wasmuth, J J, Shaw, D J, and Harper, P S
- Abstract
The search for the Huntington's disease gene has recently concentrated on the telomere of the short arm of chromosome 4. The evidence suggesting this position has been based on single crossover events, but there is conflicting evidence regarding the position of the gene relative to the most terminal markers. We have found significant linkage disequilibrium between the markers D4S98 (probe BS731B-C) and D4S95 (probe BS674E-D) and HD, which supports a localisation for the gene proximal to D4S90 and makes a telomeric localisation unlikely. This disequilibrium may also prove to be important in the future in allowing modification of risk estimates based on genetic linkage. [ABSTRACT FROM PUBLISHER]
- Published
- 1989
43. Phenotype PKD2 vs. PKD1; results from the European concerted action
- Author
-
Hateboer, N., Dijk, M., Torra, R., Bogdanova, N., Davies, F., Lazarou, L., Breuning, M., Saggarmalik, Ak, Jeffery, S., Millan, Jls, Martinez, I., Walker, R., Peter Holmans, Ravine, D., and Coles, Ga
44. RFLP for the human erb-Aβlocus
- Author
-
Wyllie, F. S., primary, Lazarou, L. P., additional, and Wynford-Thomas, D., additional
- Published
- 1988
- Full Text
- View/download PDF
45. Kinetic study of the iron(II)-induced perbromate-iodide reaction with an iodide ion selective electrode and kinetic determination of iron, perbromate, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, and ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid
- Author
-
Lazarou, L. A., primary and Hadjiioannou, T. P., additional
- Published
- 1979
- Full Text
- View/download PDF
46. Immunohistological evidence for second or somatic mutations as the underlying cause of dystrophin expression by isolated fibres in Xp21 muscular dystrophy of Duchenne-type severity
- Author
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Wallgren-Pettersson, C., Jasani, B., Rosser, L. G., and Lazarou, L. P.
- Published
- 1993
- Full Text
- View/download PDF
47. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
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Global Health Research Unit on Global Surgery, National Institute for Health and Care Research, Adisa, Adewale, Bahrami-Hessari, Michael, Bhangu, Aneel, George, Christina, Ghosh, Dhruv, Glasbey, James, Haque, Parvez, Ingabire, J C Allen, Kamarajah, Sivesh Kathir, Kudrna, Laura, Ledda, Virginia, Li, Elizabeth, Lillywhite, Robert, Mittal, Rohin, Nepogodiev, Dmitri, Ntirenganya, Faustin, Picciochi, Maria, Simões, Joana Filipa Ferreira, Booth, L, Elliot, R, Kennerton, A S, Pettigrove, K L, Pinney, L, Richard, H, Tottman, R, Wheatstone, P, Wolfenden, John W D, Smith, A, Sayed, A Emad, Goswami, Aakansha Giri, Malik, Aamer, Mclean, Aaron Lawson, Hassan, Abbas, Nazimi, Abd Jabar, Aladna, Abdallah, Abdelgawad, Abdalrahman, Saed, Abdel, Abdelmageed, Abdelfatah, Ghannam, Abdelilah, Mahmoud, Abdelrahman, Alvi, Abdul, Ismail, Abdulaziz, Adesunkanmi, Abdulhafiz, Ebrahim, Abdulla, Al-Mallah, Abdullah, Alqallaf, Abdullah, Durrani, Abdullah, Gabr, Abdullah, Kirfi, Abdullahi Musa, Altaf, Abdulmalik, Almutairi, Abdulmjeed, Sabbagh, Abdulrahman J, Ajiya, Abdulrazak, Haddud, Abdurrahman, Alnsour, Abed Alfattah Mahmoud, Singh, Abhinav, Mittal, Abhishek, Semple, Abigail, Adeniran, Abiodun, Negussie, Abraham, Oladimeji, Abraham, Muhammad, Abubakar Bala, Yassin, Abubaker, Gungor, Abuzer, Tarsitano, Achille, Soibiharry, Adaiah, Dyas, Adam, Frankel, Adam, Peckham-Cooper, Adam, Truss, Adam, Issaka, Adamu, Ads, Adel Mohamed, Aderogba, Adeleke Akeem, Adeyeye, Ademola, Ademuyiwa, Adesoji, Sleem, Adham, Papa, Adrian, Cordova, Adriana, Appiah-Kubi, Adu, Meead, Adullah, Nacion, Aeris Jane D, Michael, Afieharo, Forneris, Agustin Albani, Duro, Agustin, Gonzalez, Agustin Rodriguez, Altouny, Ahmad, Ghazal, Ahmad, Khalifa, Ahmad, Ozair, Ahmad, Quzli, Ahmad, Haddad, Ahmad, Othman, Ahmad Faidzal, Yahaya, Ahmad Shuib, Elsherbiny, Ahmed, Nazer, Ahmed, Tarek, Ahmed, Abu-Zaid, Ahmed, Al-Nusairi, Ahmed, Azab, Ahmed, Elagili, Ahmed, Elkazaz, Ahmed, Kedwany, Ahmed, Nuhu, Ahmed Mohammed, Sakr, Ahmed, Shehta, Ahmed, Shirazi, Ahmed, Mohamed, Ahmed Mohamed Ibrahim, Sherif, Ahmed Elshawadfy, Awad, Ahmed K, Abbas, Ahmed M, Abdelrahman, Ahmed Saber, Ammar, Ahmed Siddique, Azzam, Ahmed Y, Ciftci, Ahmet Burak, Dural, Ahmet Cem, Sanli, Ahmet Necati, Rahy-Martín, Aida Cristina, Tantri, Aida Rosita, Khan, Aimal, Al-Touny, Aiman, Tariq, Aiman, Gmati, Aimen, Costas-Chavarri, Ainhoa, Auerkari, Aino, Landaluce-Olavarria, Aitor, Puri, Ajay, Radhakrishnan, Ajay, Ubom, Akaninyene Eseme, Pradhan, Akhilesh, Turna, Akif, Adepiti, Akinfolarin, Kuriyama, Akira, Kassam, Al-Faraaz, Hassouneh, Ala, El-Hussuna, Alaa, Habeebullah, Alaa, Ads, Alaa Mohamed, Mousli, Alaa, Biloslavo, Alan, Hoang, Alan, Kirk, Alan, Santini, Alasdair, Melero, Alba Vazquez, Calvache, Albaro José Nieto, Baduell, Albert, Chan, Albert, Abrate, Alberto, Balduzzi, Alberto, Sánchez, Alberto Cabañero, Navarrete-Peón, Alberto, Porcu, Alberto, Brolese, Alberto, Barranquero, Alberto G, Saibene, Alberto Maria, Adam, Albushra Altayeb, Vagge, Aldo, Maquilón, Alejandra Jara, Leon-Andrino, Alejandro, Sekulić, Aleksandar, Trifunovski, Aleksandar, Mako, Aleksandro, Bedada, Alemayehu Ginbo, Broglia, Alessandro, Coppola, Alessandro, Giani, Alessandro, Grandi, Alessandro, Iacomino, Alessandro, Moro, Alessandro, D’amico, Alessia, Malagnino, Alessia, Tang, Alethea, Doyle, Alex, Alfieri, Alex, Haynes, Alex, Wilkins, Alex, Baldwin, Alexander, Heriot, Alexander, Laird, Alexander, Lazarides, Alexander, O'connor, Alexander, Trulson, Alexander, Rokohl, Alexander Christopher, Caziuc, Alexandra, Triantafyllou, Alexandra, Anesi, Alexandre, Nikova, Alexandrina, Andrianakis, Alexandros, Charalabopoulos, Alexandros, Tsolakidis, Alexandros, Chirca, Alexandru, Arnaud, Alexis P, Narvaez-Rojas, Alexis Rafael, Kavalakat, Alfie, Spina, Alfio, Recordare, Alfonso, Annicchiarico, Alfredo, Conti, Alfredo, Mohammed, Alhassan Datti, Kocataş, Ali, Almhimid, Ali, Arnaout, Ali, Fahmy, Ali, Mangi, Ali, Modabber, Ali, Ulas, Ali Bilal, Mohamedahmed, Ali Yasen Y, Frontali, Alice, Moynihan, Alice, Yunus, Alif, Ahmad, Aline, Kent, Alistair J, Khamees, Almu'atasim, Ugwu, Aloy Okechukwu, Turan, Alparslan, Mohammed, Alsnosy Abdullah Khalefa, Navarro-Barrios, Alvaro, Yebes, Alvaro, De Sousa, Álvaro Francisco Lopes, Moreno, Amabelle, Sethi, Aman, Dawson, Amanda Caroline, Othman, Amani Alsayd Abdulsalam, Kaur, Amanjot, Wolde, Amanuel, Antonelli, Amedeo, Scifo, Amedeo, Alhamad, Ameen, Davis, Amelia, Alderazi, Amer, Harky, Amer, Mohammed-Durosinlorun, Amina, Seguya, Amina, Okhakhu, Amina, Chamakhi, Amine, Sebai, Amine, Souadka, Amine, Asla, Amir, Agrawal, Amit, Persad, Amit, Gupta, Amit, Elgazar, Amr, Kulkarni, Amruta, Coates, Amy, Bellés, Ana Ciscar, Hadzibegovic, Ana Danic, Jotic, Ana, Kowark, Ana, Martins, Ana, Pineda, Ana Mejía, Peral, Ana, Gollarte, Ana Sánchez, Senent-Boza, Ana, Camarena, Ana Isabel Avellaneda, Castaño-Leon, Ana M, Bravo, Ana Maria Minaya, Moro, Ana María Gimeno, Musina, Ana-Maria, Tapia-Herrero, Ana-María, Kothari, Anai, Gupta, 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- Subjects
general surgery ,acute care surgery ,Settore MED/18 - CHIRURGIA GENERALE ,climate change ,trauma ,Settore MED/40 - Ginecologia E Ostetricia ,environmental impact ,surgery ,Settore MED/31 - Otorinolaringoiatria ,None ,Medicine and Health Sciences ,Surgery ,operating theatre ,environment - Abstract
Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.
- Published
- 2023
48. Clinical presentation and long-term outcomes of infantile hypertrophic cardiomyopathy: a European multicentre study
- Author
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Katie Linter, Gali S. Kolt, Satish Adwani, Gabrielle Norrish, Fabrizio Drago, Marta Rubino, Maria Ilina, Vinay Bhole, Kathleen Dady, Tara Bharucha, Elspeth Brown, Iacopo Olivotto, Laz Lazarou, Graham Stuart, Martina Caiazza, Amos Wong, Caroline Jones, Amrit Lota, Grazia Delle Donne, Orhan Uzun, Anca Popoiu, Silvia Passantino, Jon Searle, Juan Pablo Kaski, Silvia Favilli, Lidia Ziółkowska, Giuseppe Limongelli, Ella Field, Karen McLeod, Elena Cervi, Piers E.F. Daubeney, Ruth McGowan, Zdenka Reinhardt, Anwar Baban, Sujeev Mathur, Norrish, G., Kolt, G., Cervi, E., Field, E., Dady, K., Ziolkowska, L., Olivotto, I., Favilli, S., Passantino, S., Limongelli, G., Caiazza, M., Rubino, M., Baban, A., Drago, F., Mcleod, K., Ilina, M., Mcgowan, R., Stuart, G., Bhole, V., Uzun, O., Wong, A., Lazarou, L., Brown, E., Daubeney, P. E. F., Lota, A., Delle Donne, G., Linter, K., Mathur, S., Bharucha, T., Adwani, S., Searle, J., Popoiu, A., Jones, C. B., Reinhardt, Z., and Kaski, J. P.
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Systole ,Cardiomyopathy ,Disease ,Ventricular Function, Left ,Cohort Studies ,Infant‐onset ,medicine ,Humans ,Diseases of the circulatory (Cardiovascular) system ,Genetic Testing ,Genetic testing ,medicine.diagnostic_test ,business.industry ,Hazard ratio ,Hypertrophic cardiomyopathy ,Original Articles ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Prognosis ,Hypertrophic ,Infant-onset ,Inborn error of metabolism ,RC666-701 ,Cohort ,Etiology ,Original Article ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims: Children presenting with hypertrophic cardiomyopathy (HCM) in infancy are reported to have a poor prognosis, but this heterogeneous group has not been systematically characterized. This study aimed to describe the aetiology, phenotype, and outcomes of infantile HCM in a well-characterized multicentre European cohort. Methods and results: Of 301 children diagnosed with infantile HCM between 1987 and 2019 presenting to 17 European centres [male n=187 (62.1%)], underlying aetiology was non-syndromic (n=138, 45.6%), RASopathy (n=101, 33.6%), or inborn error of metabolism (IEM) (n=49, 16.3%). The most common reasons for presentation were symptoms (n=77, 29.3%), which were more prevalent in those with syndromic disease (n=62, 61.4%, P 
- Published
- 2021
49. P159 - Urodynamic assessment of orthotopic neobladder reconstruction following radical cystectomy in bladder cancer.
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Kostakopoulos, N., Argiropoulos, V., Tsirkas, K., Spiropoulos, K., Lazarou, L., Varkarakis, I., and Skolarikos, A.
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BLADDER cancer , *CYSTECTOMY , *URODYNAMICS , *BIOLOGICAL fluid dynamics , *MEDICAL care - Published
- 2018
- Full Text
- View/download PDF
50. Sleep Quality and Urinary Incontinence in Prostate Cancer Patients: A Data Analytics Approach with the ASCAPE Dataset.
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Manolitsis I, Feretzakis G, Tzelves L, Anastasiou A, Koumpouros Y, Verykios VS, Katsimperis S, Bellos T, Lazarou L, and Varkarakis I
- Abstract
Background: The ASCAPE project aims to improve the health-related quality of life of cancer patients using artificial intelligence (AI)-driven solutions. The current study employs a comprehensive dataset to evaluate sleep and urinary incontinence, thus enabling the development of personalized interventions., Methods: This study focuses on prostate cancer patients eligible for curative treatment with surgery. Forty-two participants were enrolled following their diagnosis and were followed up at baseline and 3, 6, 9, and 12 months after surgical treatment. The data collection process involved a combination of standardized questionnaires and wearable devices, providing a holistic view of patients' QoL and health outcomes. The dataset is systematically organized and stored in a centralized database, with advanced statistical and AI techniques being employed to reveal correlations, patterns, and predictive markers that can ultimately lead to implementing personalized intervention strategies, ultimately enhancing patient QoL outcomes., Results: The correlation analysis between sleep quality and urinary symptoms post-surgery revealed a moderate positive correlation between baseline insomnia and baseline urinary symptoms (r = 0.407, p = 0.011), a positive correlation between baseline insomnia and urinary symptoms at 3 months (r = 0.321, p = 0.049), and significant correlations between insomnia at 12 months and urinary symptoms at 3 months (r = 0.396, p = 0.014) and at 6 months (r = 0.384, p = 0.017). Furthermore, modeling the relationship between baseline insomnia and baseline urinary symptoms showed that baseline insomnia is significantly associated with baseline urinary symptoms (coef = 0.222, p = 0.036)., Conclusions: The investigation of sleep quality and urinary incontinence via data analysis through the ASCAPE project suggests that better sleep quality could improve urinary disorders.
- Published
- 2024
- Full Text
- View/download PDF
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