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1. Correction to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study

Author

Sakr, Yasser, Ferrer, Ricard, Reinhart, Konrad, Beale, Richard, Rhodes, Andrew, Moreno, Rui, Timsit, Jean Francois, Brochard, Laurent, Thompson, B. Taylor, Rezende, Ederlon, Chiche, Jean Daniel, Auer, J., Schatzl, G., Mach, K., Gruber, H., Schreurs, E., Vander Laenen, M., Ceunen, H., Wauters, J., Francois, G., Deschamps, P., Castanares, D., Debels, D., Pierrakos, C., Vincent, J. L., Taccone, F., Vymazal, T., Gornik, I., Vujiaklija Brajkovic, A., Medici, R., Nielsen, J., Bendtsen, A., Siegel, H., Suonsyrjä, T., Hraech, S., Daviaux, F., Guillot, M., Castelain, V., Losser, R-R., Novy, E., Bouadma, L., Misset, B., Philippart, F., Mallat, J., Zogheib, E., Miclo, M., Teboul, J-L., Anguel, N., Darmon, M., Pham, T., Barberet, G., Plantefeve, G., Floccard, B., Kheladze, Z., Bloos, F., Faltlhauser, A., Helmes, T., Zacharowski, K., Meybohm, P., Schwarzkopf, K., Christ, M., Baumgaertel, M., John, S., Nentwich, J., Deja, M., Goldmann, A., Gottschalk, A., Honig, F., Siepe, B., Goebel, U., Lehmke, J., Behrens, S., Fiedler, K., Sagoschen, I., Riessen, R., Haap, M., Simon, Ph., Kaisers, U., Behrens, S., Niesen, M., Jaschinski, U., Hoersch, S., Jung, A., Allgaeuer, S., Haake, H., Lange, A., Papanikolaou, M., Balla, M., Giannakou, M., Soultati, I., Nikos, G., Koulouras, V., Kyriazopoulos, G., Gkika, D., Vlachogianni, G., Psaroulis, K., Mouloudi, E., Massa, E., Nichol, A., Meany, E., Motherway, C., Bellani, G., Pota, V., Schiavone, V., Girardis, M., Busani, S., Petrucci, N., Di Pasquale, R., Mazzini, P., Molin, A., Pellerano, G., Volta, C., Spadaro, S., Guarracino, F., Savioli, M., Pellis, T., Chinellato, N., Gatta, A., Cecchini, F., Raineri, S. M., Cortegiani, A., Kekstas, G., Karosas, V., Anguseva, T., Mitrev, Z., Beck, O., Cimic, N., Janssen, G., Bormans, L., Kuiper, M., Koopmans, K., Den Boer, S., de Groot, M., Dennesen, P., van den Bosch, J., Kluge, G., Mikaszewska-Sokolewicz, M., Lazowski, T., Chruscikowski, M., Machon, J., Adamik, B., Kübler, A., Wieczorek, A., Afonso, S., Matos, R., Catorze, N., Araujo, A., Costa, Z., Pais-de-Lacerda, A., Martins, I., Cardiga, R., Fernandes, L., Serra, I., Martinho, A., Tomescu, D., Popescu, M., Scarlatescu, E., Stoica, R., Macri, A., Filipescu, D., Rupnik, E., Tomic, V., Sifrer, F., Sole Violan, J., Ferrer Agüero, J. M., Izura, J., Monedero, P., de Cabo, C. Muños, Aguilar, G., Belda, F. J., Blanquer, J., Nives Carbonell, E., Lopez-Delgado, J-C., Aragon, C., Joya, C., Ortiz-Leyba, C., Fernandez Gonzalez, C. J., de la Torre-Prados, M-V., Puerto-Morlan, A., Araujo Aguilar, P., Tomás Marsilla, J. I., Vera Aratcoz, P., Olmo, A., Ferrer Roca, R., Catalan, R. M., Garcia Olivares, P., Albis, A., Alvarez, M., Corcoles Gonzalez, V., Gutierrez Rubio, J. M., Montoiro Allue, R., Rubio Mateo-Sidron, J., Hobrok, M., Cecconi, M., Di Tomasso, N., Raj, A., Szakmany, T., Srinivasa, L., Mathew, S., Ferguson, A., Blahut-Zugaj, M., Watters, M., Henderson, S., Sim, M., Csabi, P., O’Neill, O., Nutt, C., Humphreys, S., Bhowmick, K., Donnelly, A., O’Kane, S., Garfield, M., Jha, R., Unni, N., Gordon, A., Rubulotta, F., Ravi, K., Lunch, G., Franco, F., Higgs, D., Strandvik, G., Jonas, A., Hopkins, Ph., Hurst, T., Bellini, A., Balogun, O., Srinivasan, R., Ostermann, M., Alexander, P., McCalman, K., Bedford, J., Fulop, M., Brescia, G., Strachan, J., Meyer, J., Stotz, M., Brett, S., Zand, F., Nikandish, R., Hashemian, S., Jamaati, H., Alsheikhly, A. S., Almekhlafi, G., Albarrak, M., Maghrabi, A., Salahuddin, N., Aisa, T., Atalan, H. K., Sungur, M., Hegazi, M., Bauer, P., Mukkera, S., Fried, J., Barger, M., Gueret, R., Gonzalez, C., Lovesio, C., Dellera, Ch., Barrios, D., Leite Mendes, C., Gottardo, P., Caser, E., Santos, C., Carvalho, A., Teixeira, C., Samaniego, W., Whittle, S., Molano, D., Rojas, A., Guerra, K., Villamagua, B., Salgado-Yepez, E., Morocho, D., Remache-Vargas, N., Ñamendys-Silva, S., Rodriguez, D., Dominguez, G., Barraza, G., Bermudez-Aceves, E., Sanchez-Hurtado, L. A., Baltazar-Torres, J. A., Quispe Sierra, R., Chavez, C., von Osten, I., Van Haren, C., Smalley, N., Kol, M., Wong, H., Smith, R., Yu, L., Wu, X., Chao, L., Zhai, Q., Wu, D., Zhang, X., Jing, X., Bigornia, R., Ikeda-Maquiling, Y., Robles, J., Palo, J. E., Nguyen, T., Dao, C., Dixit, S., Gurjar, M., Reddy, P., Pravin, A., Simran, S., Ramakrishnan, N., Shetty, R., Udwadia, F., Faraz, M., Indraratna, K., Rajasinhe, J., and IC-GLOSSARI Investigators and ESICM Trials Group

Published
2017
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2. Erratum to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC‐GLOSSARI): a multicenter, multinational, 14-day inception cohort study (Intensive Care Medicine, (2016), 42, 5, (953), 10.1007/s00134-016-4317-4)

Author

Auer J., Auer, J, Schatzl, G, Mach, K, Gruber, H, Schreurs, E, Vander Laenen, M, Ceunen, H, Wauters, J, Francois, G, Deschamps, P, Castanares, D, Debels, D, Pierrakos, C, Vincent, J, Taccone, F, Vymazal, T, Gornik, I, Vujiaklija Brajkovic, A, Medici, R, Nielsen, J, Bendtsen, A, Siegel, H, Suonsyrja, T, Hraech, S, Chiche, J, Daviaux, F, Guillot, M, Castelain, V, Losser, R, Novy, E, Timsit, J, Bouadma, L, Misset, B, Philippart, F, Mallat, J, Zogheib, E, Miclo, M, Teboul, J, Anguel, N, Darmon, M, Pham, T, Barberet, G, Plantefeve, G, Floccard, B, Kheladze, Z, Reinhart, K, Sakr, Y, Bloos, F, Faltlhauser, A, Helmes, T, Zacharowski, K, Meybohm, P, Schwarzkopf, K, Christ, M, Baumgaertel, M, John, S, Nentwich, J, Deja, M, Goldmann, A, Gottschalk, A, Honig, F, Siepe, B, Goebel, U, Lehmke, J, Behrens, S, Fiedler, K, Sagoschen, I, Riessen, R, Haap, M, Simon, P, Kaisers, U, Niesen, M, Jaschinski, U, Hoersch, S, Jung, A, Allgaeuer, S, Haake, H, Lange, A, Papanikolaou, M, Balla, M, Giannakou, M, Soultati, I, Nikos, G, Koulouras, V, Kyriazopoulos, G, Gkika, D, Vlachogianni, G, Psaroulis, K, Mouloudi, E, Massa, E, Nichol, A, Meany, E, Motherway, C, Bellani, G, Pota, V, Schiavone, V, Girardis, M, Busani, S, Petrucci, N, Di Pasquale, R, Mazzini, P, Molin, A, Pellerano, G, Volta, C, Spadaro, S, Guarracino, F, Savioli, M, Pellis, T, Chinellato, N, Gatta, A, Cecchini, F, Raineri, S, Cortegiani, A, Kekstas, G, Karosas, V, Anguseva, T, Mitrev, Z, Beck, O, Cimic, N, Janssen, G, Bormans, L, Kuiper, M, Koopmans, K, Den Boer, S, de Groot, M, Dennesen, P, van den Bosch, J, Kluge, G, Mikaszewska-Sokolewicz, M, Lazowski, T, Chruscikowski, M, Machon, J, Adamik, B, Kubler, A, Wieczorek, A, Afonso, S, Matos, R, Catorze, N, Araujo, A, Costa, Z, Pais-de-Lacerda, A, Martins, I, Cardiga, R, Fernandes, L, Serra, I, Martinho, A, Tomescu, D, Popescu, M, Scarlatescu, E, Stoica, R, Macri, A, Filipescu, D, Rupnik, E, Tomic, V, Sifrer, F, Sole Violan, J, Ferrer Aguero, J, Izura, B, Monedero, P, Munos de Cabo, C, Aguilar, G, Belda, F, Blanquer, J, Nives Carbonell, E, Lopez-Delgado, J, Aragon, C, Joya, C, Ortiz-Leyba, C, Fernandez Gonzalez, C, de la Torre-Prados, M, Puerto-Morlan, A, Araujo Aguilar, P, Tomas Marsilla, J, Vera Aratcoz, P, Olmo, A, Ferrer Roca, R, Catalan, R, Garcia Olivares, P, Albis, A, Alvarez, M, Corcoles Gonzalez, V, Gutierrez Rubio, J, Montoiro Allue, R, Rubio Mateo-Sidron, J, Hobrok, M, Cecconi, M, Di Tomasso, N, Raj, A, Szakmany, T, Srinivasa, L, Mathew, S, Ferguson, A, Blahut-Zugaj, M, Watters, M, Henderson, S, Sim, M, Csabi, P, O'Neill, O, Nutt, C, Humphreys, S, Bhowmick, K, Donnelly, A, O'Kane, S, Garfield, M, Jha, R, Unni, N, Gordon, A, Rubulotta, F, Ravi, K, Lunch, G, Franco, F, Higgs, D, Strandvik, G, Jonas, A, Hopkins, P, Hurst, T, Bellini, A, Balogun, O, Srinivasan, R, Ostermann, M, Alexander, P, Mccalman, K, Bedford, J, Fulop, M, Brescia, G, Strachan, J, Meyer, J, Stotz, M, Brett, S, Zand, F, Nikandish, R, Hashemian, S, Jamaati, H, Alsheikhly, A, Almekhlafi, G, Albarrak, M, Maghrabi, A, Salahuddin, N, Aisa, T, Atalan, H, Sungur, M, Hegazi, M, Bauer, P, Mukkera, S, Fried, J, Barger, M, Gueret, R, Gonzalez, C, Lovesio, C, Dellera, C, Barrios, D, Leite Mendes, C, Gottardo, P, Caser, E, Santos, C, Carvalho, A, Teixeira, C, Samaniego, W, Whittle, S, Molano, D, Rojas, A, Guerra, K, Villamagua, B, Salgado-Yepez, E, Morocho, D, Remache-Vargas, N, Namendys-Silva, S, Rodriguez, D, Dominguez, G, Barraza, G, Bermudez-Aceves, E, Sanchez-Hurtado, L, Baltazar-Torres, J, Quispe Sierra, R, Chavez, C, von Osten, I, Van Haren, C, Smalley, N, Kol, M, Wong, H, Smith, R, Yu, L, Wu, X, Chao, L, Zhai, Q, Wu, D, Zhang, X, Jing, X, Bigornia, R, Ikeda-Maquiling, Y, Robles, J, Palo, J, Nguyen, T, Dao, C, Dixit, S, Gurjar, M, Reddy, P, Pravin, A, Simran, S, Ramakrishnan, N, Shetty, R, Udwadia, F, Faraz, M, Indraratna, K, Rajasinhe, J, Auer J., Schatzl G., Mach K., Gruber H., Schreurs E., Vander Laenen M., Ceunen H., Wauters J., Francois G., Deschamps P., Castanares D., Debels D., Pierrakos C., Vincent J. L., Taccone F., Vymazal T., Gornik I., Vujiaklija Brajkovic A., Medici R., Nielsen J., Bendtsen A., Siegel H., Suonsyrja T., Hraech S., Chiche J. -D., Daviaux F., Guillot M., Castelain V., Losser R. -R., Novy E., Timsit J. -F., Bouadma L., Misset B., Philippart F., Mallat J., Zogheib E., Miclo M., Teboul J. -L., Anguel N., Darmon M., Pham T., Barberet G., Plantefeve G., Floccard B., Kheladze Z., Reinhart K., Sakr Y., Bloos F., Faltlhauser A., Helmes T., Zacharowski K., Meybohm P., Schwarzkopf K., Christ M., Baumgaertel M., John S., Nentwich J., Deja M., Goldmann A., Gottschalk A., Honig F., Siepe B., Goebel U., Lehmke J., Behrens S., Fiedler K., Sagoschen I., Riessen R., Haap M., Simon P., Kaisers U., Niesen M., Jaschinski U., Hoersch S., Jung A., Allgaeuer S., Haake H., Lange A., Papanikolaou M., Balla M., Giannakou M., Soultati I., Nikos G., Koulouras V., Kyriazopoulos G., Gkika D., Vlachogianni G., Psaroulis K., Mouloudi E., Massa E., Nichol A., Meany E., Motherway C., Bellani G., Pota V., Schiavone V., Girardis M., Busani S., Petrucci N., Di Pasquale R., Mazzini P., Molin A., Pellerano G., Volta C., Spadaro S., Guarracino F., Savioli M., Pellis T., Chinellato N., Gatta A., Cecchini F., Raineri S. M., Cortegiani A., Kekstas G., Karosas V., Anguseva T., Mitrev Z., Beck O., Cimic N., Janssen G., Bormans L., Kuiper M., Koopmans K., Den Boer S., de Groot M., Dennesen P., van den Bosch J., Kluge G., Mikaszewska-Sokolewicz M., Lazowski T., Chruscikowski M., Machon J., Adamik B., Kubler A., Wieczorek A., Afonso S., Matos R., Catorze N., Araujo A., Costa Z., Pais-de-Lacerda A., Martins I., Cardiga R., Fernandes L., Serra I., Martinho A., Tomescu D., Popescu M., Scarlatescu E., Stoica R., Macri A., Filipescu D., Rupnik E., Tomic V., Sifrer F., Sole Violan J., Ferrer Aguero J. M., Izura B. J., Monedero P., Munos de Cabo C., Aguilar G., Belda F. J., Blanquer J., Nives Carbonell E., Lopez-Delgado J. -C., Aragon C., Joya C., Ortiz-Leyba C., Fernandez Gonzalez C. J., de la Torre-Prados M. -V., Puerto-Morlan A., Araujo Aguilar P., Tomas Marsilla J. I., Vera Aratcoz P., Olmo A., Ferrer Roca R., Catalan R. M., Garcia Olivares P., Albis A., Alvarez M., Corcoles Gonzalez V., Gutierrez Rubio J. M., Montoiro Allue R., Rubio Mateo-Sidron J., Hobrok M., Cecconi M., Di Tomasso N., Raj A., Szakmany T., Srinivasa L., Mathew S., Ferguson A., Blahut-Zugaj M., Watters M., Henderson S., Sim M., Csabi P., O'Neill O., Nutt C., Humphreys S., Bhowmick K., Donnelly A., O'Kane S., Garfield M., Jha R., Unni N., Gordon A., Rubulotta F., Ravi K., Lunch G., Franco F., Higgs D., Strandvik G., Jonas A., Hopkins P., Hurst T., Bellini A., Balogun O., Srinivasan R., Ostermann M., Alexander P., McCalman K., Bedford J., Fulop M., Brescia G., Strachan J., Meyer J., Stotz M., Brett S., Zand F., Nikandish R., Hashemian S., Jamaati H., Alsheikhly A. S., Almekhlafi G., Albarrak M., Maghrabi A., Salahuddin N., Aisa T., Atalan H. K., Sungur M., Hegazi M., Bauer P., Mukkera S., Fried J., Barger M., Gueret R., Gonzalez C., Lovesio C., Dellera C., Barrios D., Leite Mendes C., Gottardo P., Caser E., Santos C., Carvalho A., Teixeira C., Samaniego W., Whittle S., Molano D., Rojas A., Guerra K., Villamagua B., Salgado-Yepez E., Morocho D., Remache-Vargas N., Namendys-Silva S., Rodriguez D., Dominguez G., Barraza G., Bermudez-Aceves E., Sanchez-Hurtado L. A., Baltazar-Torres J. A., Quispe Sierra R., Chavez C., von Osten I., Van Haren C., Smalley N., Kol M., Wong H., Smith R., Yu L., Wu X., Chao L., Zhai Q., Wu D., Zhang X., Jing X., Bigornia R., Ikeda-Maquiling Y., Robles J., Palo J. E., Nguyen T., Dao C., Dixit S., Gurjar M., Reddy P., Pravin A., Simran S., Ramakrishnan N., Shetty R., Udwadia F., Faraz M., Indraratna K., Rajasinhe J., Auer J., Auer, J, Schatzl, G, Mach, K, Gruber, H, Schreurs, E, Vander Laenen, M, Ceunen, H, Wauters, J, Francois, G, Deschamps, P, Castanares, D, Debels, D, Pierrakos, C, Vincent, J, Taccone, F, Vymazal, T, Gornik, I, Vujiaklija Brajkovic, A, Medici, R, Nielsen, J, Bendtsen, A, Siegel, H, Suonsyrja, T, Hraech, S, Chiche, J, Daviaux, F, Guillot, M, Castelain, V, Losser, R, Novy, E, Timsit, J, Bouadma, L, Misset, B, Philippart, F, Mallat, J, Zogheib, E, Miclo, M, Teboul, J, Anguel, N, Darmon, M, Pham, T, Barberet, G, Plantefeve, G, Floccard, B, Kheladze, Z, Reinhart, K, Sakr, Y, Bloos, F, Faltlhauser, A, Helmes, T, Zacharowski, K, Meybohm, P, Schwarzkopf, K, Christ, M, Baumgaertel, M, John, S, Nentwich, J, Deja, M, Goldmann, A, Gottschalk, A, Honig, F, Siepe, B, Goebel, U, Lehmke, J, Behrens, S, Fiedler, K, Sagoschen, I, Riessen, R, Haap, M, Simon, P, Kaisers, U, Niesen, M, Jaschinski, U, Hoersch, S, Jung, A, Allgaeuer, S, Haake, H, Lange, A, Papanikolaou, M, Balla, M, Giannakou, M, Soultati, I, Nikos, G, Koulouras, V, Kyriazopoulos, G, Gkika, D, Vlachogianni, G, Psaroulis, K, Mouloudi, E, Massa, E, Nichol, A, Meany, E, Motherway, C, Bellani, G, Pota, V, Schiavone, V, Girardis, M, Busani, S, Petrucci, N, Di Pasquale, R, Mazzini, P, Molin, A, Pellerano, G, Volta, C, Spadaro, S, Guarracino, F, Savioli, M, Pellis, T, Chinellato, N, Gatta, A, Cecchini, F, Raineri, S, Cortegiani, A, Kekstas, G, Karosas, V, Anguseva, T, Mitrev, Z, Beck, O, Cimic, N, Janssen, G, Bormans, L, Kuiper, M, Koopmans, K, Den Boer, S, de Groot, M, Dennesen, P, van den Bosch, J, Kluge, G, Mikaszewska-Sokolewicz, M, Lazowski, T, Chruscikowski, M, Machon, J, Adamik, B, Kubler, A, Wieczorek, A, Afonso, S, Matos, R, Catorze, N, Araujo, A, Costa, Z, Pais-de-Lacerda, A, Martins, I, Cardiga, R, Fernandes, L, Serra, I, Martinho, A, Tomescu, D, Popescu, M, Scarlatescu, E, Stoica, R, Macri, A, Filipescu, D, Rupnik, E, Tomic, V, Sifrer, F, Sole Violan, J, Ferrer Aguero, J, Izura, B, Monedero, P, Munos de Cabo, C, Aguilar, G, Belda, F, Blanquer, J, Nives Carbonell, E, Lopez-Delgado, J, Aragon, C, Joya, C, Ortiz-Leyba, C, Fernandez Gonzalez, C, de la Torre-Prados, M, Puerto-Morlan, A, Araujo Aguilar, P, Tomas Marsilla, J, Vera Aratcoz, P, Olmo, A, Ferrer Roca, R, Catalan, R, Garcia Olivares, P, Albis, A, Alvarez, M, Corcoles Gonzalez, V, Gutierrez Rubio, J, Montoiro Allue, R, Rubio Mateo-Sidron, J, Hobrok, M, Cecconi, M, Di Tomasso, N, Raj, A, Szakmany, T, Srinivasa, L, Mathew, S, Ferguson, A, Blahut-Zugaj, M, Watters, M, Henderson, S, Sim, M, Csabi, P, O'Neill, O, Nutt, C, Humphreys, S, Bhowmick, K, Donnelly, A, O'Kane, S, Garfield, M, Jha, R, Unni, N, Gordon, A, Rubulotta, F, Ravi, K, Lunch, G, Franco, F, Higgs, D, Strandvik, G, Jonas, A, Hopkins, P, Hurst, T, Bellini, A, Balogun, O, Srinivasan, R, Ostermann, M, Alexander, P, Mccalman, K, Bedford, J, Fulop, M, Brescia, G, Strachan, J, Meyer, J, Stotz, M, Brett, S, Zand, F, Nikandish, R, Hashemian, S, Jamaati, H, Alsheikhly, A, Almekhlafi, G, Albarrak, M, Maghrabi, A, Salahuddin, N, Aisa, T, Atalan, H, Sungur, M, Hegazi, M, Bauer, P, Mukkera, S, Fried, J, Barger, M, Gueret, R, Gonzalez, C, Lovesio, C, Dellera, C, Barrios, D, Leite Mendes, C, Gottardo, P, Caser, E, Santos, C, Carvalho, A, Teixeira, C, Samaniego, W, Whittle, S, Molano, D, Rojas, A, Guerra, K, Villamagua, B, Salgado-Yepez, E, Morocho, D, Remache-Vargas, N, Namendys-Silva, S, Rodriguez, D, Dominguez, G, Barraza, G, Bermudez-Aceves, E, Sanchez-Hurtado, L, Baltazar-Torres, J, Quispe Sierra, R, Chavez, C, von Osten, I, Van Haren, C, Smalley, N, Kol, M, Wong, H, Smith, R, Yu, L, Wu, X, Chao, L, Zhai, Q, Wu, D, Zhang, X, Jing, X, Bigornia, R, Ikeda-Maquiling, Y, Robles, J, Palo, J, Nguyen, T, Dao, C, Dixit, S, Gurjar, M, Reddy, P, Pravin, A, Simran, S, Ramakrishnan, N, Shetty, R, Udwadia, F, Faraz, M, Indraratna, K, Rajasinhe, J, Auer J., Schatzl G., Mach K., Gruber H., Schreurs E., Vander Laenen M., Ceunen H., Wauters J., Francois G., Deschamps P., Castanares D., Debels D., Pierrakos C., Vincent J. L., Taccone F., Vymazal T., Gornik I., Vujiaklija Brajkovic A., Medici R., Nielsen J., Bendtsen A., Siegel H., Suonsyrja T., Hraech S., Chiche J. -D., Daviaux F., Guillot M., Castelain V., Losser R. -R., Novy E., Timsit J. -F., Bouadma L., Misset B., Philippart F., Mallat J., Zogheib E., Miclo M., Teboul J. -L., Anguel N., Darmon M., Pham T., Barberet G., Plantefeve G., Floccard B., Kheladze Z., Reinhart K., Sakr Y., Bloos F., Faltlhauser A., Helmes T., Zacharowski K., Meybohm P., Schwarzkopf K., Christ M., Baumgaertel M., John S., Nentwich J., Deja M., Goldmann A., Gottschalk A., Honig F., Siepe B., Goebel U., Lehmke J., Behrens S., Fiedler K., Sagoschen I., Riessen R., Haap M., Simon P., Kaisers U., Niesen M., Jaschinski U., Hoersch S., Jung A., Allgaeuer S., Haake H., Lange A., Papanikolaou M., Balla M., Giannakou M., Soultati I., Nikos G., Koulouras V., Kyriazopoulos G., Gkika D., Vlachogianni G., Psaroulis K., Mouloudi E., Massa E., Nichol A., Meany E., Motherway C., Bellani G., Pota V., Schiavone V., Girardis M., Busani S., Petrucci N., Di Pasquale R., Mazzini P., Molin A., Pellerano G., Volta C., Spadaro S., Guarracino F., Savioli M., Pellis T., Chinellato N., Gatta A., Cecchini F., Raineri S. M., Cortegiani A., Kekstas G., Karosas V., Anguseva T., Mitrev Z., Beck O., Cimic N., Janssen G., Bormans L., Kuiper M., Koopmans K., Den Boer S., de Groot M., Dennesen P., van den Bosch J., Kluge G., Mikaszewska-Sokolewicz M., Lazowski T., Chruscikowski M., Machon J., Adamik B., Kubler A., Wieczorek A., Afonso S., Matos R., Catorze N., Araujo A., Costa Z., Pais-de-Lacerda A., Martins I., Cardiga R., Fernandes L., Serra I., Martinho A., Tomescu D., Popescu M., Scarlatescu E., Stoica R., Macri A., Filipescu D., Rupnik E., Tomic V., Sifrer F., Sole Violan J., Ferrer Aguero J. M., Izura B. J., Monedero P., Munos de Cabo C., Aguilar G., Belda F. J., Blanquer J., Nives Carbonell E., Lopez-Delgado J. -C., Aragon C., Joya C., Ortiz-Leyba C., Fernandez Gonzalez C. J., de la Torre-Prados M. -V., Puerto-Morlan A., Araujo Aguilar P., Tomas Marsilla J. I., Vera Aratcoz P., Olmo A., Ferrer Roca R., Catalan R. M., Garcia Olivares P., Albis A., Alvarez M., Corcoles Gonzalez V., Gutierrez Rubio J. M., Montoiro Allue R., Rubio Mateo-Sidron J., Hobrok M., Cecconi M., Di Tomasso N., Raj A., Szakmany T., Srinivasa L., Mathew S., Ferguson A., Blahut-Zugaj M., Watters M., Henderson S., Sim M., Csabi P., O'Neill O., Nutt C., Humphreys S., Bhowmick K., Donnelly A., O'Kane S., Garfield M., Jha R., Unni N., Gordon A., Rubulotta F., Ravi K., Lunch G., Franco F., Higgs D., Strandvik G., Jonas A., Hopkins P., Hurst T., Bellini A., Balogun O., Srinivasan R., Ostermann M., Alexander P., McCalman K., Bedford J., Fulop M., Brescia G., Strachan J., Meyer J., Stotz M., Brett S., Zand F., Nikandish R., Hashemian S., Jamaati H., Alsheikhly A. S., Almekhlafi G., Albarrak M., Maghrabi A., Salahuddin N., Aisa T., Atalan H. K., Sungur M., Hegazi M., Bauer P., Mukkera S., Fried J., Barger M., Gueret R., Gonzalez C., Lovesio C., Dellera C., Barrios D., Leite Mendes C., Gottardo P., Caser E., Santos C., Carvalho A., Teixeira C., Samaniego W., Whittle S., Molano D., Rojas A., Guerra K., Villamagua B., Salgado-Yepez E., Morocho D., Remache-Vargas N., Namendys-Silva S., Rodriguez D., Dominguez G., Barraza G., Bermudez-Aceves E., Sanchez-Hurtado L. A., Baltazar-Torres J. A., Quispe Sierra R., Chavez C., von Osten I., Van Haren C., Smalley N., Kol M., Wong H., Smith R., Yu L., Wu X., Chao L., Zhai Q., Wu D., Zhang X., Jing X., Bigornia R., Ikeda-Maquiling Y., Robles J., Palo J. E., Nguyen T., Dao C., Dixit S., Gurjar M., Reddy P., Pravin A., Simran S., Ramakrishnan N., Shetty R., Udwadia F., Faraz M., Indraratna K., and Rajasinhe J.

Abstract

In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to list the members of the groups here: (Table presented.).

Published
2018

3. Erratum to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC‑GLOSSARI): a multicenter, multinational, 14-day inception cohort study (Intensive Care Medicine, (2016), 42, 5, (953), 10.1007/s00134-016-4317-4)

Author

Sakr, Yasser, Ferrer, Ricard, Reinhart, Konrad, Beale, Richard, Rhodes, Andrew, Moreno, Rui, Timsit, Jean Francois, Brochard, Laurent, Thompson, B. Taylor, Rezende, Ederlon, Chiche, Jean Daniel, Auer, J., Schatzl, G., Mach, K., Gruber, H., Schreurs, E., Vander Laenen, M., Ceunen, H., Wauters, J., Francois, G., Deschamps, P., Castanares, D., Debels, D., Pierrakos, C., Vincent, J. L., Taccone, F., Vymazal, T., Gornik, I., Vujiaklija Brajkovic, A., Medici, R., Nielsen, J., Bendtsen, A., Siegel, H., Suonsyrjä, T., Hraech, S., Daviaux, F., Guillot, M., Castelain, V., Losser, R. -R., Novy, E., Bouadma, L., Misset, B., Philippart, F., Mallat, J., Zogheib, E., Miclo, M., Teboul, J. -L., Anguel, N., Darmon, M., Pham, T., Barberet, G., Plantefeve, G., Floccard, B., Kheladze, Z., Bloos, F., Faltlhauser, A., Helmes, T., Zacharowski, K., Meybohm, P., Schwarzkopf, K., Christ, M., Baumgaertel, M., John, S., Nentwich, J., Deja, M., Goldmann, A., Gottschalk, A., Honig, F., Siepe, B., Goebel, U., Lehmke, J., Behrens, S., Fiedler, K., Sagoschen, I., Riessen, R., Haap, M., Simon, Ph., Kaisers, U., Niesen, M., Jaschinski, U., Hoersch, S., Jung, A., Allgaeuer, S., Haake, H., Lange, A., Papanikolaou, M., Balla, M., Giannakou, M., Soultati, I., Nikos, G., Koulouras, V., Kyriazopoulos, G., Gkika, D., Vlachogianni, G., Psaroulis, K., Mouloudi, E., Massa, E., Nichol, A., Meany, E., Motherway, C., Bellani, G., Pota, V., Schiavone, V., Girardis, M., Busani, S., Petrucci, N., Di Pasquale, R., Mazzini, P., Molin, A., Pellerano, G., Volta, C., Spadaro, S., Guarracino, F., Savioli, M., Pellis, T., Chinellato, N., Gatta, A., Cecchini, F., Raineri, S. M., Cortegiani, A., Kekstas, G., Karosas, V., Anguseva, T., Mitrev, Z., Beck, O., Cimic, N., Janssen, G., Bormans, L., Kuiper, M., Koopmans, K., Den Boer, S., de Groot, M., Dennesen, P., van den Bosch, J., Kluge, G., Mikaszewska-Sokolewicz, M., Lazowski, T., Chruscikowski, M., Machon, J., Adamik, B., Kübler, A., Wieczorek, A., Afonso, S., Matos, R., Catorze, N., Araujo, A., Costa, Z., Pais-de-Lacerda, A., Martins, I., Cardiga, R., Fernandes, L., Serra, I., Martinho, A., Tomescu, D., Popescu, M., Scarlatescu, E., Stoica, R., Macri, A., Filipescu, D., Rupnik, E., Tomic, V., Sifrer, F., Sole Violan, J., Ferrer Agüero, J. M., Izura, J., Monedero, P., de Cabo, C. Muños, Aguilar, G., Belda, F. J., Blanquer, J., Nives Carbonell, E., Lopez-Delgado, J. -C., Aragon, C., Joya, C., Ortiz-Leyba, C., Fernandez Gonzalez, C. J., de la Torre-Prados, M. -V., Puerto-Morlan, A., Araujo Aguilar, P., Tomás Marsilla, J. I., Vera Aratcoz, P., Olmo, A., Ferrer Roca, R., Catalan, R. M., Garcia Olivares, P., Albis, A., Alvarez, M., Corcoles Gonzalez, V., Gutierrez Rubio, J. M., Montoiro Allue, R., Rubio Mateo-Sidron, J., Hobrok, M., Cecconi, M., Di Tomasso, N., Raj, A., Szakmany, T., Srinivasa, L., Mathew, S., Ferguson, A., Blahut-Zugaj, M., Watters, M., Henderson, S., Sim, M., Csabi, P., O’Neill, O., Nutt, C., Humphreys, S., Bhowmick, K., Donnelly, A., O’Kane, S., Garfield, M., Jha, R., Unni, N., Gordon, A., Rubulotta, F., Ravi, K., Lunch, G., Franco, F., Higgs, D., Strandvik, G., Jonas, A., Hopkins, Ph., Hurst, T., Bellini, A., Balogun, O., Srinivasan, R., Ostermann, M., Alexander, P., McCalman, K., Bedford, J., Fulop, M., Brescia, G., Strachan, J., Meyer, J., Stotz, M., Brett, S., Zand, F., Nikandish, R., Hashemian, S., Jamaati, H., Alsheikhly, A. S., Almekhlafi, G., Albarrak, M., Maghrabi, A., Salahuddin, N., Aisa, T., Atalan, H. K., Sungur, M., Hegazi, M., Bauer, P., Mukkera, S., Fried, J., Barger, M., Gueret, R., Gonzalez, C., Lovesio, C., Dellera, Ch., Barrios, D., Leite Mendes, C., Gottardo, P., Caser, E., Santos, C., Carvalho, A., Teixeira, C., Samaniego, W., Whittle, S., Molano, D., Rojas, A., Guerra, K., Villamagua, B., Salgado-Yepez, E., Morocho, D., Remache-Vargas, N., Ñamendys-Silva, S., Rodriguez, D., Dominguez, G., Barraza, G., Bermudez-Aceves, E., Sanchez-Hurtado, L. A., Baltazar-Torres, J. A., Quispe Sierra, R., Chavez, C., von Osten, I., Van Haren, C., Smalley, N., Kol, M., Wong, H., Smith, R., Yu, L., Wu, X., Chao, L., Zhai, Q., Wu, D., Zhang, X., Jing, X., Bigornia, R., Ikeda-Maquiling, Y., Robles, J., Palo, J. E., Nguyen, T., Dao, C., Dixit, S., Gurjar, M., Reddy, P., Pravin, A., Simran, S., Ramakrishnan, N., Shetty, R., Udwadia, F., Faraz, M., Indraratna, K., Rajasinhe, J., Sakr, Yasser, Ferrer, Ricard, Reinhart, Konrad, Beale, Richard, Rhodes, Andrew, Moreno, Rui, Timsit, Jean Francoi, Brochard, Laurent, Thompson, B. Taylor, Rezende, Ederlon, Chiche, Jean Daniel, Auer, J., Schatzl, G., Mach, K., Gruber, H., Schreurs, E., Vander Laenen, M., Ceunen, H., Wauters, J., Francois, G., Deschamps, P., Castanares, D., Debels, D., Pierrakos, C., Vincent, J.L., Taccone, F., Vymazal, T., Gornik, I., Vujiaklija Brajkovic, A., Medici, R., Nielsen, J., Bendtsen, A., Siegel, H., Suonsyrjä, T., Hraech, S., Daviaux, F., Guillot, M., Castelain, V., Losser, R.-R., Novy, E., Bouadma, L., Misset, B., Philippart, F., Mallat, J., Zogheib, E., Miclo, M., Teboul, J.-L., Anguel, N., Darmon, M., Pham, T., Barberet, G., Plantefeve, G., Floccard, B., Kheladze, Z., Bloos, F., Faltlhauser, A., Helmes, T., Zacharowski, K., Meybohm, P., Schwarzkopf, K., Christ, M., Baumgaertel, M., John, S., Nentwich, J., Deja, M., Goldmann, A., Gottschalk, A., Honig, F., Siepe, B., Goebel, U., Lehmke, J., Behrens, S., Fiedler, K., Sagoschen, I., Riessen, R., Haap, M., Simon, Ph., Kaisers, U., Niesen, M., Jaschinski, U., Hoersch, S., Jung, A., Allgaeuer, S., Haake, H., Lange, A., Papanikolaou, M., Balla, M., Giannakou, M., Soultati, I., Nikos, G., Koulouras, V., Kyriazopoulos, G., Gkika, D., Vlachogianni, G., Psaroulis, K., Mouloudi, E., Massa, E., Nichol, A., Meany, E., Motherway, C., Bellani, G., Pota, V., Schiavone, V., Girardis, M., Busani, S., Petrucci, N., Di Pasquale, R., Mazzini, P., Molin, A., Pellerano, G., Volta, C., Spadaro, S., Guarracino, F., Savioli, M., Pellis, T., Chinellato, N., Gatta, A., Cecchini, F., Raineri, S.M., Cortegiani, A., Kekstas, G., Karosas, V., Anguseva, T., Mitrev, Z., Beck, O., Cimic, N., Janssen, G., Bormans, L., Kuiper, M., Koopmans, K., Den Boer, S., de Groot, M., Dennesen, P., van den Bosch, J., Kluge, G., Mikaszewska-Sokolewicz, M., Lazowski, T., Chruscikowski, M., Machon, J., Adamik, B., Kübler, A., Wieczorek, A., Afonso, S., Matos, R., Catorze, N., Araujo, A., Costa, Z., Pais-de-Lacerda, A., Martins, I., Cardiga, R., Fernandes, L., Serra, I., Martinho, A., Tomescu, D., Popescu, M., Scarlatescu, E., Stoica, R., Macri, A., Filipescu, D., Rupnik, E., Tomic, V., Sifrer, F., Sole Violan, J., Ferrer Agüero, J.M., Izura, J., Monedero, P., de Cabo, C. Muño, Aguilar, G., Belda, F.J., Blanquer, J., Nives Carbonell, E., Lopez-Delgado, J.-C., Aragon, C., Joya, C., Ortiz-Leyba, C., Fernandez Gonzalez, C.J., de la Torre-Prados, M.-V., Puerto-Morlan, A., Araujo Aguilar, P., Tomás Marsilla, J.I., Vera Aratcoz, P., Olmo, A., Ferrer Roca, R., Catalan, R.M., Garcia Olivares, P., Albis, A., Alvarez, M., Corcoles Gonzalez, V., Gutierrez Rubio, J.M., Montoiro Allue, R., Rubio Mateo-Sidron, J., Hobrok, M., Cecconi, M., Di Tomasso, N., Raj, A., Szakmany, T., Srinivasa, L., Mathew, S., Ferguson, A., Blahut-Zugaj, M., Watters, M., Henderson, S., Sim, M., Csabi, P., O’Neill, O., Nutt, C., Humphreys, S., Bhowmick, K., Donnelly, A., O’Kane, S., Garfield, M., Jha, R., Unni, N., Gordon, A., Rubulotta, F., Ravi, K., Lunch, G., Franco, F., Higgs, D., Strandvik, G., Jonas, A., Hopkins, Ph., Hurst, T., Bellini, A., Balogun, O., Srinivasan, R., Ostermann, M., Alexander, P., McCalman, K., Bedford, J., Fulop, M., Brescia, G., Strachan, J., Meyer, J., Stotz, M., Brett, S., Zand, F., Nikandish, R., Hashemian, S., Jamaati, H., Alsheikhly, A.S., Almekhlafi, G., Albarrak, M., Maghrabi, A., Salahuddin, N., Aisa, T., Atalan, H.K., Sungur, M., Hegazi, M., Bauer, P., Mukkera, S., Fried, J., Barger, M., Gueret, R., Gonzalez, C., Lovesio, C., Dellera, Ch., Barrios, D., Leite Mendes, C., Gottardo, P., Caser, E., Santos, C., Carvalho, A., Teixeira, C., Samaniego, W., Whittle, S., Molano, D., Rojas, A., Guerra, K., Villamagua, B., Salgado-Yepez, E., Morocho, D., Remache-Vargas, N., Ñamendys-Silva, S., Rodriguez, D., Dominguez, G., Barraza, G., Bermudez-Aceves, E., Sanchez-Hurtado, L.A., Baltazar-Torres, J.A., Quispe Sierra, R., Chavez, C., von Osten, I., Van Haren, C., Smalley, N., Kol, M., Wong, H., Smith, R., Yu, L., Wu, X., Chao, L., Zhai, Q., Wu, D., Zhang, X., Jing, X., Bigornia, R., Ikeda-Maquiling, Y., Robles, J., Palo, J.E., Nguyen, T., Dao, C., Dixit, S., Gurjar, M., Reddy, P., Pravin, A., Simran, S., Ramakrishnan, N., Shetty, R., Udwadia, F., Faraz, M., Indraratna, K., and Rajasinhe, J.

Subjects
Critical Care and Intensive Care Medicine
Abstract

In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to list the members of the groups here: (Table presented.).

Published
2018

15. Perioperative single high dose ATG-Fresenius S administration as induction immunosuppressive therapy in cadaveric renal transplantation--preliminary results

Author

Samsel R, Chmura A, Włodarczyk Z, Wyzgał J, Cieciura T, Lagiewska B, Pliszczyński J, Korczak G, Lazowski T, Leszek Paczek, Wałaszewski J, Lao M, and Rowiński W

Subjects
Adult, Graft Rejection, Male, T-Lymphocytes, Middle Aged, Kidney Transplantation, Acute Disease, Cadaver, Humans, Female, Prospective Studies, Safety, Immunosuppressive Agents, Antilymphocyte Serum
Abstract

Monoclonal and polyclonal antilymphocyte antibodies have been used successfully in organ transplantation as induction therapy and in the treatment of acute graft rejection. Used for induction the medication is generally given for the first 7-10 days. The aim of this study was to assess the safety and efficacy of single high dose (9 mg/kg) ATG Fresenius S given perioperatively, before revascularization, to kidney allograft recipients. During last twelve months seventy six, first cadaveric kidney adult recipients were included into the study in two centers (center A-64, center B-12). All patients received triple drug immunosuppression (Neoral, steroids and Cellcept which was replaced by azathioprine after 4 months), and were randomized to receive ATG or not. The follow-up period ranged from 1 month up to 1 year. The preliminary results are very promising, the rejection rate in bolus group was significantly lower than in control. No significant side effects or serious adverse events in both groups were observed.

16. The effects of in vitro hemodilution and fibrinogen concentrate substitution on thromboelastometry analysis in patients qualified for liver transplantation - preliminary results.

Author

Nicińska B, Pluta J, Kosieradzki M, Lągiewska B, Wasiak D, Lazowski T, Chmura A, and Trzebicki J

Subjects
Adult, Blood Coagulation Tests, Case-Control Studies, Female, Fibrinogen biosynthesis, Hemorrhage etiology, Hemostasis, Hemostatics, Humans, Hydroxyethyl Starch Derivatives, In Vitro Techniques, Liver Cirrhosis blood, Liver Cirrhosis pathology, Male, Middle Aged, Prospective Studies, Blood Coagulation Disorders drug therapy, Fibrinogen pharmacology, Hemodilution adverse effects, Liver Transplantation, Thrombelastography methods
Abstract

Background: Dilutional coagulopathy might cause life-threatening hemorrhages in liver transplantation. Liver insufficiency is usually accompanied by alteration in fibrinogen (Fib) synthesis, which is one of the main clotting factors providing appropriate hemostasis. Intraoperative hemodilution results in further Fib concentration reduction enhancing coagulopathy and blood loss. Exogenous Fib substitution might prevent this., Methods: A prospective study with a control group was designed. The study group consists of patients with cirrhosis who qualified for liver transplantation. Inclusion and exclusion criteria were strictly established. The blood collected from participants was diluted up to 30% and 60% with crystalloid (saline) or colloid (hydroxyethyl starch) in 2 parallel series. The first series consisted of diluted blood, the second of diluted blood with Fib concentrate. Thromboelastometry tests were performed on every blood sample. After collecting data from the first 12 participants, we performed a preliminary analysis., Results: The maximum clot formation (MCF) in the EXTEM test decreased with progressive blood dilution in both study arms. The MCF values were lower than 35 mm in every diluted blood sample of the study group. The recovery of decreased MCF after Fib concentrate substitution was observed in both groups. The improvement in clot formation was also expressed as amplitude of clot firmness in the 10th minute (A10) in the FIBTEM test., Conclusions: Clot formation is disturbed more profoundly by hemodilution in cirrhotic patients. Fib concentrate substitution might be effective in the management of dilutional coagulopathy.

Published
2014
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17. The prognostic value of concomitant assessment of NT-proCNP, C-reactive protein, procalcitonin and inflammatory cytokines in septic patients.

Author

Tomasiuk R, Mikaszewska-Sokolewicz M, Szlufik S, Rzepecki P, and Lazowski T

Subjects
Biomarkers blood, Calcitonin Gene-Related Peptide, Humans, Intensive Care Units, Prognosis, Sepsis mortality, C-Reactive Protein metabolism, Calcitonin blood, Cytokines blood, Natriuretic Peptide, C-Type blood, Protein Precursors blood, Sepsis blood
Published
2014
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18. Bioequivalence and pharmacokinetics of two 10-mg bisoprolol formulations as film-coated tablets in healthy white volunteers: a randomized, crossover, open-label, 2-period, single-dose, fasting study.

Author

Bus-Kwasnik K, Ksycinska H, Les A, Serafin-Byczak K, Rudzki PJ, Raszek J, Lazowski T, Bielak A, and Wybraniec A

Subjects
Adult, Bisoprolol adverse effects, Chemistry, Pharmaceutical, Cross-Over Studies, Fasting, Female, Humans, Male, Tablets, Enteric-Coated, Therapeutic Equivalency, Adrenergic beta-1 Receptor Antagonists pharmacokinetics, Bisoprolol pharmacokinetics
Abstract

Objective: The aim of the study was to investigate the bioavailability of a generic formulation of 10-mg bisoprolol film coated tablets (test) as compared to that of a branded formulation (reference) at the same strength to determine bioequivalence and to apply for regulatory approval. The secondary objective of the study was to evaluate tolerability of both formulations., Methods: A randomized, crossover, open-label, 2-period, single-dose, comparative study was conducted in healthy white volunteers in fasting conditions. A single oral dose administration of the test or reference formulation was followed by a 14-day wash-out period. Blood samples were collected up to 60 hours after dosing. The bisoprolol concentrations in plasma samples were determined using a validated LC-MS/MS method. The formulations were considered bioequivalent if 90% CI of geometric mean ratios (test/reference) for AUC0-t, AUC0-∞ and Cmax were within the range 80.00 - 25.00%. Adverse events were monitored throughout the study based on the clinical parameters and volunteer reports., Results: Healthy male and female subjects participating in the study had a median (range) age of 23 (20 - 43), weight of 68 kg (52 - 84), height of 172 cm (157 - 184), and BMI of 23.1 kg/m2 (19.3 - 24.9). The 26 consented volunteers have been included and 24 of them completed the clinical part of the study. The geometric mean test/referenceratios (90% CI) for AUC0-t, AUC0-∞ and Cmax were 104.12% (100.52 - 107.85%), 104.05% (100.49 - 107.75%) and 107.91% (103.04 - 112.99%), respectively. All 90% CI were embraced by the 80.00 - 25.00% acceptance interval. No serious adverse events were reported. A total number of 6 non-serious, moderate adverse events were registered, including headache and vomiting in one subject., Conclusions: The results of the single-dose study in healthy white volunteers indicated that the film-coated tablets of Bisocard® 10 mg manufactured by ICN Polfa Rzeszów S.A. (test formulation) are bioequivalent to those of Concor 10® manufactured by Merck KGaA (reference formulation). Both formulations were well tolerated.

Published
2012
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19. Over 500 obturator nerve blocks in the lithotomy position during transurethral resection of bladder tumor.

Author

Pladzyk K, Jureczko L, and Lazowski T

Abstract

Introduction and Aim of the Study: Spinal anesthesia for transurethral resection of bladder tumor (TURB) does not prevent unintended stimulation of the obturator nerve when electroresection is performed on the lateral wall of the bladder. It results in muscle contraction of the adductor muscles of the thigh, which may lead to perforation of bladder wall with the resectoscope loop. The aim of the study was to assess the efficacy and safety of obturator nerve block (ONB)., Methods: This prospective study was conducted between 01/01/1999 and 12/31/2010 in the Department of General, Oncologic and Functional Urology, Medical University of Warsaw. In 431 patients undergoing TURB adductor spasms were observed. In these cases nerve stimulation and ONB with 2% lidocaine using thigh interadductor approach in the lithotomy position were performed., Results: The efficacy of 542 ONB was 94%. In 31 cases general anesthesia was necessary. There were two cases of urinary bladder perforation, but only one resulted from an insufficient nerve block. Both were managed conservatively. Neither hematomas nor neurological adverse events were observed., Conclusion: The described method offers a high rate of efficacy and ensures optimal and safe conditions for the resection of a tumor located on the inferolateral wall of the urinary bladder. The risk of complication is low.

Published
2012
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20. Unexpected fatal right ventricular rupture during liver transplantation: case report.

Author

Trzebicki J, Lisik W, Blaszczyk B, Pacholczyk M, Fudalej M, Chmura A, and Lazowski T

Subjects
Cardiac Tamponade etiology, Catheterization, Swan-Ganz adverse effects, End Stage Liver Disease surgery, Fatal Outcome, Humans, Liver Transplantation instrumentation, Male, Middle Aged, Postoperative Complications etiology, Time Factors, Heart Injuries etiology, Liver Transplantation adverse effects
Abstract

Background: The pulmonary artery catheter provides most hemodynamic informations, which are necessary for the patient monitoring during liver transplantation. However, its application may be associated with complications., Case Report: Authors present a case of unexpected right ventricular rupture during liver transplantation in a 53-year-old male, with end-stage liver disease secondary to hepatitis C virus and alcohol abuse. The most likely cause of this complication was myocardial scarification of right ventricle during introducer sheath inserting. There was six hours period between vessel cannulation and the first signs of heart failure, which occurred in the final anhepatic phase. Attempts to surgical repair of damaged heart wall failed and the patient died., Conclusions: Based on the present case analysis we suggest to restrict the introduction depth of dilatator and possibly shorten it 2-3 cm by the manufacturer. We should also note that time elapsed from the vessel cannulation to cardiac tamponade first signs does not preclude this procedure as a cause of this fatal complications.

Published
2011

21. Premature labor after fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia: post-procedure management problems.

Author

Wegrzyn P, Weigl W, Szymusik I, Ejmocka-Ambroziak A, Kamińska A, Dziadecki W, Lazowski T, and Wielgoś M

Subjects
Adult, Fatal Outcome, Female, Hernias, Diaphragmatic, Congenital, Humans, Infant, Newborn, Male, Obstetric Labor, Premature, Pregnancy, Balloon Occlusion adverse effects, Fetal Diseases surgery, Hernia, Diaphragmatic surgery, Trachea surgery
Published
2010
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22. The use of thromboelastometry in the assessment of hemostasis during orthotopic liver transplantation reduces the demand for blood products.

Author

Trzebicki J, Flakiewicz E, Kosieradzki M, Blaszczyk B, Kołacz M, Jureczko L, Pacholczyk M, Chmura A, Lagiewska B, Lisik W, Wasiak D, Kosson D, Kwiatkowski A, and Lazowski T

Subjects
Adult, Antifibrinolytic Agents pharmacology, Antifibrinolytic Agents therapeutic use, Aprotinin pharmacology, Aprotinin therapeutic use, Blood Coagulation drug effects, Female, Fibrinolysis drug effects, Hemorrhage prevention & control, Humans, Male, Middle Aged, Platelet Transfusion adverse effects, Tranexamic Acid pharmacology, Tranexamic Acid therapeutic use, Transfusion Reaction, Blood Coagulation Tests methods, Hemostasis, Liver Transplantation adverse effects
Abstract

Background: Bleeding due to fibrinolysis is a serious intraoperative complication during orthotopic liver transplantation (OLT). For a number of years aprotinin was used to minimize risk of this complication. This drug was however banned in 2007 and substituted with other antifibrinolytics. The aim of the study was to assess the potential of intraoperative thromboelastometry to evaluate hemostasis and channelize antifibrinolytic therapy., Material/methods: Since ban on aprotinin, 39 patients underwent OLT in our center with no monitoring of fibrinolysis (NMF). Severe disturbances of hemostasis assessed clinically only as a need for blood and blood products transfusion and were treated with transfusion of fresh frozen plasma only. In 2008 we started to use thromboelastometry (ROTEM group, n=39), which allowed for targeted treatment of hyperfibrinolysis with tranexamic acid., Results: The need for blood transfusion in ROTEM group was insignificantly a lower than in NMF group (4.1±4.76 vs 5.53±4.89 units, p=0.2). Patients from ROTEM group required also less plasma transfusions (10.01±7.47 vs 13.15±6.62, p=0.06). Severe fibrinolysis was found in 3 patients from ROTEM group (7.7%) and was treated with tranexamic acid., Conclusions: Thromboelastometry provides an immediate diagnosis of fibrinolysis, justifies implementation of targeted treatment and confirms effectiveness of the therapy. In a larger study group it can also result in significant minimization of blood products transfusion during OLT.

Published
2010

23. Thoracic epidural analgesia in anaesthesia for liver transplantation: the 10-year experience of a single centre.

Author

Trzebicki J, Nicinska B, Blaszczyk B, Jureczko L, Kolacz M, Pacholczyk M, Chmura A, Lagiewska B, Adadynski L, Malkowski P, Wasiak D, Lisik W, Kwiatkowski A, and Lazowski T

Subjects
Adult, Analgesia, Epidural adverse effects, Anesthesia, Intravenous methods, Female, Humans, Male, Middle Aged, Poland, Prospective Studies, Respiration, Artificial, Analgesia, Epidural methods, Liver Transplantation methods
Abstract

Background: Improvements in operating techniques, methods of anaesthesia and postoperative care in liver transplantation (LT) contribute to better outcomes. In order to restrict postoperative mechanical ventilation, a thoracic epidural analgesia (TEA) has been performed in our centre since 2000. In this report we present our 10-year experience of using TEA as a component of LT anaesthesia., Material/methods: TEA was performed, by anaesthetists experienced in this method, on patients qualified for LT, who consented and met inclusion criteria: INR<1.5, APTT<45s and platelets >70 G/L. Since 2008 the decision to insert an epidural catheter has been additionally supported by thromboelastometry. We assessed extubation time, frequency of complications of TEA and undesired accidents., Results: From 279 patients undergoing LT, TEA was performed on 67 (24%), and from these 56 (84%) were extubated in the operating theatre. There were 5 cases of unsatisfactory thoracic epidural analgesia. Only 1 epidural catheter was removed accidentally, on the 2nd postoperative day. None of the complications of TEA were observed in the TEA group., Conclusions: Based on our observations, it can be assumed that TEA done by experienced an anaesthetist is a safe component of anaesthesia in selected groups of patients undergoing LT, and allows for early extubation.

Published
2010

24. Electron microscope investigation of the role of Chlamydia sp. in the process of rebuilding the arterial wall. Neoangiogenesis in atherosclerotic plaques in human cervical artery walls.

Author

Walski M, Lazowski T, Szostek M, Opolski G, Celary-Walska R, Andruszkiewicz P, and Ryba M

Subjects
Aged, Arteries microbiology, Arteriosclerosis microbiology, Arteriosclerosis pathology, Endothelium, Vascular microbiology, Erythrocytes metabolism, Female, Humans, Male, Microscopy, Electron, Middle Aged, Neovascularization, Physiologic, Arteries ultrastructure, Chlamydia ultrastructure, Endothelium, Vascular ultrastructure
Abstract

Background: The inflammatory process has an essential impact on the development of atherosclerosis. Three mechanisms are mentioned: 1) possibility of direct development of Chlamydia infection in the vicinity of the blood vessel wall; 2) impact of persistent or recurrrent Chlamydia infection on the increased blood concentration of risk factors for atherosclerosis; 3) an autoimmunological reaction., Material/methods: Electron microscope examinations were performed on specimens from atherosclerotic lesions of the interior cervical arteries, collected from patients who had undergone endarterectomy. The material came from 8 patients (age from 58 to 72). The specimens were fixed for electron microscopy, and after dehydration were immersed in Spurr resin. Ultrathin slices were examined under a transmission electron microscope., Results: In the successive tested layers nearest the lumen of the vessel we found erythrocytic elements, fibrin, and lipid membranes. In deeper layers there were lymphocytic cells, monocytes, and macrophages loaded with phagocyted lipid material. Under this layer we found in some specimens a coating which had undergone mineralization: calcium structures and cholesterol were overlaid on a proteoglycanate base. Smooth muscles cells had undergone the heaviest proliferation among the cells on artery wall. In the tested material we detected diversified morphological forms of Chlamydia sp. Particular attention should be drawn to the appearance of very young vessel forms, which suggests a process of angiogenesis in the atherosclerotic plaques., Conclusions: We found that one of the pathogens that may lead to atherosclerotic lesions is Chlamydia sp. The process of atherogenesis in cervical arteries is accompanied by angiogenetic processes.

Published
2002

25. The influence of the type of anaesthesia on postoperative pain after kidney transplantation.

Author

Lazowski T

Subjects
Adolescent, Adult, Aged, Fentanyl, Halothane, Humans, Isoflurane, Middle Aged, Morphine therapeutic use, Nitrous Oxide, Propofol, Analgesia, Patient-Controlled, Anesthesia methods, Kidney Transplantation, Pain, Postoperative drug therapy
Abstract

The postoperative pain treatment is one of important factors of a successful outcome after kidney transplantation. Improperly controlled pain leads to agitation, tachycardia, hypertension and increases risk of respiratory complications. Many studies have demonstrated good analgetic effect of morphine delivered by the method of patient controlled analgesia (PCA). Because the intensity of postoperative pain in end-stage kidney insufficiency patients can be modified by the type of received anaesthesia, it was decided to analyze the influence of standardized general anaesthesia on postoperative morphine consumption. 140 (ASA III) patients scheduled for kidney transplantation were included. Patients were divided into four groups; group K (control)--anaesthetised with fentanyl and N2O, group 1--fentanyl, N2O plus halothane, group 2--fentanyl, N2O plus propofol, group 3--fentanyl, N2O plus isoflurane. After operation and initial loading dose, PCA infusion of morphine was started. Bolus doses were set to 30 ug/kg, and lockout interval 10 min. Our results suggest that observed greater morphine consumption after GA with the use of propofol is connected with better psychomotor functions. In that group patients were better oriented and more efficiently controlled the PCA pump and pain.

Published
2000

26. Perioperative single high dose ATG-Fresenius S administration as induction immunosuppressive therapy in cadaveric renal transplantation--preliminary results.

Author

Samsel R, Chmura A, Włodarczyk Z, Wyzgał J, Cieciura T, Lagiewska B, Pliszczyński J, Korczak G, Lazowski T, Paczek L, Wałaszewski J, Lao M, and Rowiński W

Subjects
Acute Disease, Adult, Antilymphocyte Serum adverse effects, Cadaver, Female, Graft Rejection prevention & control, Humans, Immunosuppressive Agents adverse effects, Male, Middle Aged, Prospective Studies, Safety, T-Lymphocytes immunology, Antilymphocyte Serum administration & dosage, Immunosuppressive Agents administration & dosage, Kidney Transplantation methods
Abstract

Monoclonal and polyclonal antilymphocyte antibodies have been used successfully in organ transplantation as induction therapy and in the treatment of acute graft rejection. Used for induction the medication is generally given for the first 7-10 days. The aim of this study was to assess the safety and efficacy of single high dose (9 mg/kg) ATG Fresenius S given perioperatively, before revascularization, to kidney allograft recipients. During last twelve months seventy six, first cadaveric kidney adult recipients were included into the study in two centers (center A-64, center B-12). All patients received triple drug immunosuppression (Neoral, steroids and Cellcept which was replaced by azathioprine after 4 months), and were randomized to receive ATG or not. The follow-up period ranged from 1 month up to 1 year. The preliminary results are very promising, the rejection rate in bolus group was significantly lower than in control. No significant side effects or serious adverse events in both groups were observed.

Published
1999

27. The influence of endocrine changes in donors and recipients on the immediate outcome of kidney transplantation.

Author

Rowiński W, Lao M, Cajzner S, Lagiewska B, Lazowski T, Pacholczyk M, Szostek M, and Wałaszewski J

Subjects
Adolescent, Adult, Blood Pressure, Brain Death, Cadaver, Cause of Death, Creatinine blood, Diuresis, Female, Histocompatibility Testing, Humans, Male, Middle Aged, Aldosterone blood, Atrial Natriuretic Factor blood, Kidney Transplantation physiology, Renin blood, Tissue Donors, Vasopressins blood
Published
1996

32. Decreased incidence of acute tubular necrosis after cadaveric donor transplantation due to lidocaine donor pretreatment and low-dose dopamine infusion in the recipient.

Author

Walaszewski J, Rowinski W, Chmura A, Cajzner S, Kowalczyk J, Danielewicz R, Michalak G, Nawrocki G, Lazowski T, and Zawadzki A

Subjects
Cadaver, Humans, Infusions, Intravenous, Premedication, Acute Kidney Injury prevention & control, Dopamine administration & dosage, Kidney Transplantation, Kidney Tubular Necrosis, Acute prevention & control, Lidocaine administration & dosage, Tissue Donors
Published
1988

33. [Continuous infusion of atracurium before kidney transplantation].

Author

Lazowski T, Mayzner-Zawadzka E, Witkowski K, Sosnowska M, and Wołoszczuk-Gebicka B

Subjects
Adult, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Preanesthetic Medication, Anesthesia, General, Atracurium administration & dosage, Kidney Failure, Chronic surgery, Kidney Transplantation
Published
1988

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