22 results on '"Le Bouar, Gwenaelle"'
Search Results
2. Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease
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Allegaert, Karel, Aubard, Yves, Basmaison, Odile, Benevent, Jean-Baptiste, Biquard, Florence, Champion, Gérard, Delbosc, Jean-Marie, Eckart, Philippe, Froute, Marie-Françoise, Gaucherand, Pascal, Groussolles, Marion, Guigonis, Vincent, Hougas, Blandine, Le Bouar, Gwenaelle, Martin, Alain, Martin, Sophie, Maupin-Hyvonnet, Mariannick, Merveille, Marina, Mousty, Eve, Nobili, François, Ryckewaert, Amelie, Sartor, Agnes, Taque, Sophie, Winer, Norbert, Klein, Julie, Buffin-Meyer, Bénédicte, Boizard, Franck, Moussaoui, Nabila, Lescat, Ophélie, Breuil, Benjamin, Fedou, Camille, Feuillet, Guylène, Casemayou, Audrey, Neau, Eric, Hindryckx, An, Decatte, Luc, Levtchenko, Elena, Raaijmakers, Anke, Vayssière, Christophe, Goua, Valérie, Lucas, Charlotte, Perrotin, Franck, Cloarec, Sylvie, Benachi, Alexandra, Manca-Pellissier, Marie-Christine, Delmas, Hélène Laurichesse, Bessenay, Lucie, Le Vaillant, Claudine, Allain-Launay, Emma, Gondry, Jean, Boudailliez, Bernard, Simon, Elisabeth, Prieur, Fabienne, Lavocat, Marie-Pierre, Saliou, Anne-Hélène, De Parscau, Loic, Bidat, Laurent, Noel, Catherine, Floch, Corinne, Bourdat-Michel, Guylène, Favre, Romain, Weingertner, Anne-Sophie, Oury, Jean-François, Baudouin, Véronique, Bory, Jean-Paul, Pietrement, Christine, Fiorenza, Maryse, Massardier, Jérôme, Kessler, Sylvie, Lounis, Nadia, Auriol, Françoise Conte, Marcorelles, Pascale, Collardeau-Frachon, Sophie, Zürbig, Petra, Mischak, Harald, Magalhães, Pedro, Batut, Julie, Blader, Patrick, Saulnier Blache, Jean-Sebastien, Bascands, Jean-Loup, Schaefer, Franz, Decramer, Stéphane, and Schanstra, Joost P.
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- 2021
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3. Phénotype prénatal des microduplications 22q11 : description de 12 nouveaux cas et Revue de la littérature
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Mary, Laura, primary, Lavillaureix, Alinoë, additional, Perrot, Adélie, additional, Loget, Philippe, additional, Launay, Erika, additional, Leborgne, Anne-Sophie, additional, Demurger, Florence, additional, Fradin, Mélanie, additional, Le Bouar, Gwenaelle, additional, Quélin, Chloé, additional, Dubourg, Christèle, additional, Pasquier, Laurent, additional, Odent, Sylvie, additional, Belaud-Rotureau, Marc-Antoine, additional, and Jaillard, Sylvie, additional
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- 2022
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4. Congenital toxoplasmosis prevention by pyrimethamine-sulfadiazine vs spiramycin, a randomized trial: 31
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Mandelbrot, Laurent, Villena, Isabelle, Kieffer, Francois, Laurichesse-Delmas, Helene, Winer, Norbert, Mesnard, Louis, Berrebi, Alain, Le Bouar, Gwenaelle, Cordier, Anne-Gaelle, Sitta, Remi, and Thiebaut, Rodolphe
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- 2018
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5. Predicting the risk of respiratory distress in newborns with congenital pulmonary malformations
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Delacourt, Christophe, primary, Bertille, Nathalie, additional, Salomon, Laurent J., additional, Rahshenas, Makan, additional, Benachi, Alexandra, additional, Bonnard, Arnaud, additional, Choupeaux, Laure, additional, Fouquet, Virginie, additional, Goua, Valérie, additional, Hameury, Frédéric, additional, Hervieux, Erik, additional, Jouannic, Jean-Marie, additional, Khen-Dunlop, Naziha, additional, Le Bouar, Gwenaelle, additional, Massardier, Jérôme, additional, Roditis, Léa, additional, Rosenblatt, Jonathan, additional, Sartor, Agnès, additional, Thong-Vanh, Catherine, additional, Lelong, Nathalie, additional, and Khoshnood, Babak, additional
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- 2021
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6. Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease
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Klein, Julie, primary, Buffin-Meyer, Bénédicte, additional, Boizard, Franck, additional, Moussaoui, Nabila, additional, Lescat, Ophélie, additional, Breuil, Benjamin, additional, Fedou, Camille, additional, Feuillet, Guylène, additional, Casemayou, Audrey, additional, Neau, Eric, additional, Hindryckx, An, additional, Decatte, Luc, additional, Levtchenko, Elena, additional, Raaijmakers, Anke, additional, Vayssière, Christophe, additional, Goua, Valérie, additional, Lucas, Charlotte, additional, Perrotin, Franck, additional, Cloarec, Sylvie, additional, Benachi, Alexandra, additional, Manca-Pellissier, Marie-Christine, additional, Delmas, Hélène Laurichesse, additional, Bessenay, Lucie, additional, Le Vaillant, Claudine, additional, Allain-Launay, Emma, additional, Gondry, Jean, additional, Boudailliez, Bernard, additional, Simon, Elisabeth, additional, Prieur, Fabienne, additional, Lavocat, Marie-Pierre, additional, Saliou, Anne-Hélène, additional, De Parscau, Loic, additional, Bidat, Laurent, additional, Noel, Catherine, additional, Floch, Corinne, additional, Bourdat-Michel, Guylène, additional, Favre, Romain, additional, Weingertner, Anne-Sophie, additional, Oury, Jean-François, additional, Baudouin, Véronique, additional, Bory, Jean-Paul, additional, Pietrement, Christine, additional, Fiorenza, Maryse, additional, Massardier, Jérôme, additional, Kessler, Sylvie, additional, Lounis, Nadia, additional, Auriol, Françoise Conte, additional, Marcorelles, Pascale, additional, Collardeau-Frachon, Sophie, additional, Zürbig, Petra, additional, Mischak, Harald, additional, Magalhães, Pedro, additional, Batut, Julie, additional, Blader, Patrick, additional, Saulnier Blache, Jean-Sebastien, additional, Bascands, Jean-Loup, additional, Schaefer, Franz, additional, Decramer, Stéphane, additional, Schanstra, Joost P., additional, Allegaert, Karel, additional, Aubard, Yves, additional, Basmaison, Odile, additional, Benevent, Jean-Baptiste, additional, Biquard, Florence, additional, Champion, Gérard, additional, Delbosc, Jean-Marie, additional, Eckart, Philippe, additional, Froute, Marie-Françoise, additional, Gaucherand, Pascal, additional, Groussolles, Marion, additional, Guigonis, Vincent, additional, Hougas, Blandine, additional, Le Bouar, Gwenaelle, additional, Martin, Alain, additional, Martin, Sophie, additional, Maupin-Hyvonnet, Mariannick, additional, Merveille, Marina, additional, Mousty, Eve, additional, Nobili, François, additional, Ryckewaert, Amelie, additional, Sartor, Agnes, additional, Taque, Sophie, additional, and Winer, Norbert, additional
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- 2021
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7. The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design
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Buffin-Meyer, Bénédicte, Klein, Julie, van der Zanden, Loes F M, Levtchenko, Elena, Moulos, Panogiotis, Lounis, Nadia, Conte-Auriol, Françoise, Hindryckx, An, Wühl, Elke, Persico, Nicola, Oepkes, Dick, Schreuder, Michiel F, Tkaczyk, Marcin, Ariceta, Gema, Fossum, Magdalena, Parvex, Paloma, Feitz, Wout, Olsen, Henning, Montini, Giovanni, Decramer, Stéphane, Schanstra, Joost P, De Catte, Luc, Vayssieres, Christophe, Sartor, Agnès, Groussolles, Marion, Plard, Christelle, Guerby, Paul, Connan, Laure, Morin, Mathieu, Simon, Elizabeth, Breaud, Jean, Saliou, Anne-Hélène, De Parscau, Loic, Jay, Nadine, Germouty, Isabelle, Le Bouar, Gwenaelle, Ryckewaert, Amelie, Manca-Pellissier, Marie-Christine, Merrot, Thierry, Laurichesse, Helene, Gallot, Denis, Bessenay, Lucie, Bidat, Laurent, Boize, Philippe, Winer, Norbert, Allain-Launey, Emma, Le Vaillant, Claudine, Prieur, Fabienne, Lavocat, Marie-Pierre, Coatleven, Frederic, Debromez, Eric, Harembat, Jérôme, Llanas, Brigitte, Favre, Romain, Moog, Raphael, Zaloszyc, Ariane, Massardier, Jérôme, Demede, Delphine, Perrotin, Franck, Cloarec, Sylvie, Vequeau-Goua, Valérie, Descombes, Emmanuelle, Boulot, Pierre, Morin, Denis, Fuchs, Florent, Tenenbaum, Julie, Ville, Yves, Blanc, Thomas, Heidet, Laurence, Paris, Anne, Dobremez, Eric, Froute, Marie-Françoise, Gondry, Jean, Muszynski, Charles, Haraux, Elodie, Lobelle, Fabienne, Chevreau, Julien, Rosenblatt, Jonathan, Baudoin, Véronique, Deschenes, Georges, Guigue, Virginie, Amblard, Florence, Bourdat-Michel, Guylhène, Schaefer, Franz, Elsässer, Michael, Rossi, Federica, Manzoni, Gianantonio, De Marco, Erika A, Capone, Valentina, Caforio, Leonardo, Zaccara, Antonio, Innocenzi, Michele, Bagolan, Pietro, Capozza, Nicola, Castagnetti, Marco, Mancini, Mariangela, van Scheltema, Phebe Adama, Kortmann, Barbara, Schreuder, Michiel, Stańczyk, Małgorzata, Szaflik, Krzysztof, Wojtera, Justyna, Krzeszowski, Waldemar, Talar, Tomasz, Pawłowska, Barbara, Fortecka-Piestrzeniewicz, Katarzyna, Olejniczak, Dariusz, Arevalo, Silvia, Rodo, Carlota, Lindgren, Peter, Chehade, Hassib, ANTENATAL Consortium, Hindryckx, A., De Catte, L., Vayssieres, C., Sartor, A., Groussolles, M., Plard, C., Guerby, P., Connan, L., Morin, M., Simon, E., Breaud, J., Saliou, A.H., De Parscau, L., Jay, N., Germouty, I., Le Bouar, G., Ryckewaert, A., Manca-Pellissier, M.C., Merrot, T., Laurichesse, H., Gallot, D., Bessenay, L., Bidat, L., Boize, P., Winer, N., Allain-Launey, E., Le Vaillant, C., Prieur, F., Lavocat, M.P., Coatleven, F., Debromez, E., Harembat, J., Llanas, B., Favre, R., Moog, R., Zaloszyc, A., Massardier, J., Demede, D., Perrotin, F., Cloarec, S., Vequeau-Goua, V., Descombes, E., Boulot, P., Morin, D., Fuchs, F., Tenenbaum, J., Ville, Y., Blanc, T., Heidet, L., Paris, A., Dobremez, E., Froute, M.F., Gondry, J., Muszynski, C., Haraux, E., Lobelle, F., Chevreau, J., Rosenblatt, J., Baudoin, V., Deschenes, G., Guigue, V., Amblard, F., Bourdat-Michel, G., Wühl, E., Schaefer, F., Elsässer, M., Persico, N., Rossi, F., Manzoni, G., De Marco, E.A., Montini, G., Capone, V., Caforio, L., Zaccara, A., Innocenzi, M., Bagolan, P., Capozza, N., Castagnetti, M., Mancini, M., Oepkes, D., van Scheltema, P.A., Feitz, W., Kortmann, B., Schreuder, M., Tkaczyk, M., Stańczyk, M., Szaflik, K., Wojtera, J., Krzeszowski, W., Talar, T., Pawłowska, B., Fortecka-Piestrzeniewicz, K., Olejniczak, D., Ariceta, G., Arevalo, S., Rodo, C., Fossum, M., Lindgren, P., Parvex, P., Chehade, H., Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Radboud University Medical Center [Nijmegen], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), HybridStat Predictive Analytics [Athens, Greece], Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Heidelberg University Hospital [Heidelberg], University of Milan, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico [Milan, Italy], Leiden University Medical Center (LUMC), Radboud Institute for Molecular Life Sciences [Nijmegen, the Netherlands], Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Pediatric Nephrology [Barcelona, Spain] (Vall d’Hebron Hospital), Universitat Autònoma de Barcelona (UAB)-Vall d'Hebron University Hospital [Barcelona], Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Geneva University Hospital (HUG), Aarhus University Hospital, Aarhus University [Aarhus], Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, ANTENATAL Consortium: An Hindryckx, Luc De Catte, Christophe Vayssieres, Agnès Sartor, Marion Groussolles, Christelle Plard, Paul Guerby, Laure Connan, Mathieu Morin, Elizabeth Simon, Jean Breaud, Anne-Hélène Saliou, Loic De Parscau, Nadine Jay, Isabelle Germouty, Gwenaelle Le Bouar, Amelie Ryckewaert, Marie-Christine Manca-Pellissier, Thierry Merrot, Helene Laurichesse, Denis Gallot, Lucie Bessenay, Laurent Bidat, Philippe Boize, Norbert Winer, Emma Allain-Launey, Claudine Le Vaillant, Fabienne Prieur, Marie-Pierre Lavocat, Frederic Coatleven, Eric Debromez, Jérôme Harembat, Brigitte Llanas, Romain Favre, Raphael Moog, Ariane Zaloszyc, Jérôme Massardier, Delphine Demede, Franck Perrotin, Sylvie Cloarec, Valérie Vequeau-Goua, Emmanuelle Descombes, Pierre Boulot, Denis Morin, Florent Fuchs, Julie Tenenbaum, Yves Ville, Thomas Blanc, Laurence Heidet, Anne Paris, Eric Dobremez, Marie-Françoise Froute, Jean Gondry, Charles Muszynski, Elodie Haraux, Fabienne Lobelle, Julien Chevreau, Jonathan Rosenblatt, Véronique Baudoin, Georges Deschenes, Virginie Guigue, Florence Amblard, Guylhène Bourdat-Michel, Elke Wühl, Franz Schaefer, Michael Elsässer, Nicola Persico, Federica Rossi, Gianantonio Manzoni, Erika A De Marco, Giovanni Montini, Valentina Capone, Leonardo Caforio, Antonio Zaccara, Michele Innocenzi, Pietro Bagolan, Nicola Capozza, Marco Castagnetti, Mariangela Mancini, Dick Oepkes, Phebe Adama van Scheltema, Wout Feitz, Barbara Kortmann, Michiel Schreuder, Marcin Tkaczyk, Małgorzata Stańczyk, Krzysztof Szaflik, Justyna Wojtera, Waldemar Krzeszowski, Tomasz Talar, Barbara Pawłowska, Katarzyna Fortecka-Piestrzeniewicz, Dariusz Olejniczak, Gema Ariceta, Silvia Arevalo, Carlota Rodo, Magdalena Fossum, Peter Lindgren, Paloma Parvex, Hassib Chehade., Schanstra, Joost, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Università degli Studi di Milano = University of Milan (UNIMI)
- Subjects
Posterior urethral valve ,medicine.medical_specialty ,Urinary system ,[SDV]Life Sciences [q-bio] ,kidney disease ,prenatal biomarkers ,Renal function ,Prenatal care ,030204 cardiovascular system & hematology ,DIAGNOSIS ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,0302 clinical medicine ,Medicine ,obstructive uropathy ,Obstructive uropathy ,development ,030304 developmental biology ,RISK ,0303 health sciences ,Transplantation ,Kidney ,ddc:618 ,Science & Technology ,business.industry ,Obstetrics ,Original Articles ,prediction ,Urology & Nephrology ,Omics ,medicine.disease ,6. Clean water ,3. Good health ,[SDV] Life Sciences [q-bio] ,Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,medicine.anatomical_structure ,Nephrology ,embryonic structures ,Settore MED/20 ,URINARY-TRACT OBSTRUCTION ,Renal disorders Radboud Institute for Health Sciences [Radboudumc 11] ,business ,Life Sciences & Biomedicine ,Kidney disease - Abstract
Altres ajuts: The study is partially made possible by support of the 'Programme Hospitalier de Recherche Clinique and 'La Foundation de la Recherche Médicale (grant number DEQ20170336759, France). M.T. was supported by the Polish Mothers Memorial Hospital Research Institute (internal grant number 2016/IV/54-GW. LvdZ is supported by a Kolff grant from the Dutch Kidney Foundation (13OKJ36) and a ZonMW-VENI grant from the Netherlands Organisation for Scientific Research (91618036). This project has been supported by ERN ERKNet and ERN eUROGEN, which are partly co-funded by the European Union within the framework of the Third Health Programme 'ERN-2016-Framework Partnership Agreement 2017-2021'. Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1-β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV.
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- 2020
8. Antenatal Management of Bronchopulmonary Sequestration by Intrafetal Vascular Laser Ablation under Ultrasound Control: Narrative Review of the Literature and Report of Three Cases
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Grozdeva, Lora, primary, Senat, Marie-Victoire, additional, Vandewynckele, Nada, additional, Fouquet, Virginie, additional, Castaigne, Vanina, additional, Le Bouar, Gwenaelle, additional, Benachi, Alexandra, additional, and Bouchghoul, Hanane, additional
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- 2021
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9. Multicolor-FISH Characterization of a Prenatal Mosaicism for a Chromosomal Rearrangement Undetected by Molecular Cytogenetics
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Mary, Laura, primary, Loget, Philippe, additional, Odent, Sylvie, additional, Aussel, Dominique, additional, Le Bouar, Gwenaelle, additional, Launay, Erika, additional, Henry, Catherine, additional, Belaud-Rotureau, Marc-Antoine, additional, and Jaillard, Sylvie, additional
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- 2021
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10. Is laterality of congenital diaphragmatic hernia a reliable prognostic factor? French national cohort study
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Pinton, Anne, primary, Boubnova, Julia, additional, Becmeur, François, additional, Kuhn, Pierre, additional, Senat, Marie‐Victoire, additional, Stirnemann, Julien, additional, Capelle, Marianne, additional, Rosenblatt, Jonathan, additional, Massardier, Jérôme, additional, Vaast, Pascal, additional, Le Bouar, Gwenaelle, additional, Desrumaux, Amélie, additional, Connant, Laure, additional, Begue, Laetitia, additional, Parmentier, Benoit, additional, Perrotin, Franck, additional, Diguet, Alain, additional, Benoist, Guillaume, additional, Muszynski, Charles, additional, Scalabre, Aurélien, additional, Winer, Norbert, additional, Michel, Jean‐Luc, additional, Casagrandre‐Magne, Florence, additional, Jouannic, Jean‐Marie, additional, Gallot, Denis, additional, Coste Mazeau, Perrine, additional, Sapin, Emmanuel, additional, Maatouk, Alexis, additional, Saliou, Anne‐Hélène, additional, Sentilhes, Loïc, additional, Biquard, Florence, additional, Mottet, Nicolas, additional, Favre, Romain, additional, Benachi, Alexandra, additional, and Sananès, Nicolas, additional
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- 2020
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11. Microduplications 22q11.2 typiques et atypiques en fœtopathologie
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Perrot, Adélie, primary, Loget, Philippe, additional, Beaumont, Marion, additional, Launay, Erika, additional, Quelin, Chloé, additional, Le Bouar, Gwenaelle, additional, Rollier, Paul, additional, Fradin, Mélanie, additional, Demurger, Florence, additional, Pasquier, Laurent, additional, Odent, Sylvie, additional, Belaud-Rotureau, Marc-Antoine, additional, and Jaillard, Sylvie, additional
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- 2019
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12. Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammation
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Davalieva, Katarina, Makridakis, Manousos, Vlahou, Antonia, Frantzi, Maria, Boizard, Franck, Moussaoui, Nabila, Lescat, Ophélie, Fedou, Camille, Feuillet, Guylène, Casemayou, Audrey, Neau, Eric, Decatte, Luc, Raaijmakers, Anke, Vayssière, Christophe, Goua, Valérie, Lucas, Charlotte, Benachi, Alexandra, Delmas, Hélène Laurichesse, Allain-Launay, Emma, Boudailliez, Bernard, Simon, Elisabeth, Noel, Catherine, Floch, Corinne, Bourdat-Michel, Guylène, Weingertner, Anne-Sophie, Oury, Jean-François, Baudouin, Véronique, Bory, Jean-Paul, Pietrement, Christine, Fiorenza, Maryse, Kessler, Sylvie, Auriol, Françoise Conte, Marcorelles, Pascale, Collardeau-Frachon, Sophie, Magalhães, Pedro, Batut, Julie, Blader, Patrick, Saulnier Blache, Jean-Sebastien, Allegaert, Karel, Aubard, Yves, Basmaison, Odile, Benevent, Jean-Baptiste, Biquard, Florence, Champion, Gérard, Delbosc, Jean-Marie, Eckart, Philippe, Gaucherand, Pascal, Guigonis, Vincent, Hougas, Blandine, Martin, Alain, Martin, Sophie, Maupin-Hyvonnet, Mariannick, Merveille, Marina, Mousty, Eve, Nobili, François, Taque, Sophie, Latosinska, Agnieszka, Faguer, Stanislas, Beige, Joachim, van der Zanden, Loes, Levtchenko, Elena, Moulos, Panogiotis, Lounis, Nadia, Conte-Auriol, Françoise, Olsen, Henning, Hindryckx, An, De Catte, Luc, Vayssieres, Christophe, Sartor, Agnes, Groussolles, Marion, Plard, Christelle, Guerby, Paul, Connan, Laure, Morin, Mathieu, Simon, Elizabeth, Breaud, Jean, Saliou, Anne-Hélène, De Parscau, Loic, Jay, Nadine, Germouty, Isabelle, Le Bouar, Gwenaelle, Ryckewaert, Amelie, Manca-Pellissier, Marie-Christine, Merrot, Thierry, Laurichesse, Helene, Gallot, Denis, Bessenay, Lucie, Bidat, Laurent, Boize, Philippe, Winer, Norbert, Allain-Launey, Emma, Le Vaillant, Claudine, Prieur, Fabienne, Lavocat, Marie-Pierre, Coatleven, Frederic, Debromez, Eric, Harembat, Jérôme, Llanas, Brigitte, Favre, Romain, Moog, Raphael, Zaloszyc, Ariane, Massardier, Jérôme, DEMEDE, Delphine, Perrotin, Franck, Cloarec, Sylvie, Vequeau-Goua, Valérie, Descombes, Emmanuelle, Boulot, Pierre, Morin, Denis, Fuchs, Florent, Tenenbaum, Julie, Ville, Yves, Blanc, Thomas, Heidet, Laurence, Paris, Anne, Dobremez, Eric, Froute, Marie-Françoise, Gondry, Jean, Muszynski, Charles, Haraux, Elodie, Lobelle, Fabienne, Chevreau, Julien, Rosenblatt, Jonathan, Baudoin, Véronique, Deschenes, Georges, Guigue, Virginie, Amblard, Florence, Bourdat-Michel, Guylhène, Wühl, Elke, Schaefer, Franz, Elsässer, Michael, Persico, Nicola, Rossi, Federica, Manzoni, Gianantonio, De Marco, Erika, Montini, Giovanni, Capone, Valentina, Caforio, Leonardo, Zaccara, Antonio, Innocenzi, Michele, Bagolan, Pietro, Capozza, Nicola, Castagnetti, Marco, Mancini, Mariangela, Oepkes, Dick, van Scheltema, Phebe Adama, Feitz, Wout, Kortmann, Barbara, Schreuder, Michiel, Pawłowska, Barbara, Fortecka-Piestrzeniewicz, Katarzyna, Olejniczak, Dariusz, Ariceta, Gema, Arevalo, Silvia, RODO, Carlota, Fossum, Magdalena, Lindgren, Peter, Parvex, Paloma, Chehade, Hassib, He, Tianlin, Metzger, Jochen, Mullen, William, Mischak, Harald, Zürbig, Petra, Jankowski, Vera, Buffin-Meyer, Bénédicte, Tkaczyk, Marcin, Stańczyk, Małgorzata, Breuil, Benjamin, Siwy, Justyna, Szaflik, Krzysztof, Talar, Tomasz, Wojtera, Justyna, Krzeszowski, Waldemar, Decramer, Stéphane, Lopatko Fagerström, Ingrid, Ståhl, Anne-lie, Mossberg, Maria, Tati, Ramesh, Kristoffersson, Ann-Charlotte, Kahn, Robin, Bascands, Jean-Loup, Klein, Julie, Schanstra, Joost, Segelmark, Mårten, Karpman, Diana, Department of Pediatrics [Lund, Sweden] (Clinical Sciences), Lund University [Lund], Wallenberg Center for Molecular Medicine [Lund, Sweden], Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Nephrology [Lund, Sweden] (Clinical Sciences Lund), Department of Medical and Health Sciences [Lund, Sweden], Linköping University (LIU), The study was supported by The Swedish Research Council (K2015-99X-22877-01-6 and 2017-01920), The Knut and Alice Wallenberg Foundation (Wallenberg Clinical Scholar 2015.0320), The Torsten Söderberg Foundation, Skåne Centre of Excellence in Health, IngaBritt och Arne Lundberg's Research Foundation, Crown Princess Lovisa's Society for Child Care, Region Skåne and The Konung Gustaf V:s 80-årsfond (all to DK). Alfred Österlund Foundation (to LMFLL and RK). TheWallenberg Center forMolecular Medicine, The Swedish RheumatismAssociation, The Anna-Greta Crafoord Foundation, Greta and Johan Kock's Foundation, the Samariten Foundation, Fanny Ekdahl foundation, the Jerring foundation and the Thelma Zoegas Foundation (to RK). JPS and JK were partially funded by a grant from the 'Fondation pour la Recherche Médicale' (grant number DEQ20170336759). MS was funded by The Swedish Rheumatism Association and the Ingrid Asp Foundation., Schanstra, Joost, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), Biomedical Research Foundation of the Academy of Athens (BRFAA), Mosaiques Diagnostics & Therapeutics (MOSAIQUES DIAGNOSTICS & THERAPEUTICS), Mosaiques Diagnostics & Therapeutics AG, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut de médecine moléculaire de Rangueil (I2MR), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], KfH-Nierenzentrum und Klinikum St. Georg, Nephrologie, Leipzig, Radboud University Medical Center [Nijmegen], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), HybridStat Predictive Analytics [Athens, Greece], Centre d'investigation clinique de Toulouse (CIC 1436), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Heidelberg University Hospital [Heidelberg], University of Milan, Mosaiques Diagnostics GmbH [Hanovre, Allemagne], Institute of Cardiovascular and Medical Sciences [Glasgow], University of Glasgow, Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), RWTH Aachen University, Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Mosaiques Diagnostics GmbH [Hannover, Germany], Mosaiques Diagnostics and Therapeutics AG [Hannover, Germany], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), and Université Fédérale Toulouse Midi-Pyrénées
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0301 basic medicine ,Male ,Research paper ,Mouse ,Kallikrein-Kinin System ,[SDV]Life Sciences [q-bio] ,Pharmacology ,Kidney ,Mice ,0302 clinical medicine ,Glomerular C3 deposition ,Cell-Derived Microparticles ,Complement Activation ,Cells, Cultured ,Chemistry ,General Medicine ,Kinin ,Middle Aged ,Receptor antagonist ,3. Good health ,[SDV] Life Sciences [q-bio] ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,Endothelial microvesicles ,Complement C1 Inhibitor Protein ,Protein Binding ,Vasculitis ,Complement ,Radiology, Nuclear Medicine and Medical Imaging ,Adult ,Endothelium ,medicine.drug_class ,Inflammation ,Bradykinin ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Classical complement pathway ,medicine ,Animals ,Humans ,Aged ,Endothelial Cells ,Biological Transport ,Complement System Proteins ,Microvesicles ,Complement system ,Disease Models, Animal ,030104 developmental biology ,Immunoglobulin G ,Endothelium, Vascular ,Radiologi och bildbehandling - Abstract
Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation. Methods: Complement deposition on endothelial microvesicles was assayed in vasculitis patient plasma samples and controls. Plasma was perfused over glomerular endothelial cells and complement deposition assayed by flow cytometry. The effect of the kinin system was assessed using kinin receptor antagonists and C1-inhibitor. The in vivo effect was assessed in kidney sections from mice with nephrotoxic serum-induced glomerulonephritis treated with a kinin receptor antagonist. Findings: Vasculitis patient plasma had significantly more C3- and C9-positive endothelial microvesicles than controls. Perfusion of patient acute-phase plasma samples over glomerular endothelial cells induced the release of significantly more complement-positive microvesicles, in comparison to remission or control plasma. Complement activation on endothelial microvesicles was reduced by kinin B1- and B2-receptor antagonists or by C1-inhibitor (the main inhibitor of the classical pathway and the KKS). Likewise, perfusion of glomerular endothelial cells with C1-inhibitor-depleted plasma induced the release of complement-positive microvesicles, which was significantly reduced by kinin-receptor antagonists or C1-inhibitor. Mice with nephrotoxic serum-induced glomerulonephritis exhibited significantly reduced glomerular C3 deposition when treated with a B1-receptor antagonist. Interpretation: Excessive complement deposition on the endothelium will promote endothelial injury and the release of endothelial microvesicles. This study demonstrates that blockade of the KKS can reduce complement activation and thereby the inflammatory response on the endothelium. (C) 2019 The Authors. Published by Elsevier B.V. Funding Agencies|Swedish Research CouncilSwedish Research Council [K2015-99X-22877-01-6, 2017-01920]; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation [2015.0320]; Torsten Soderberg Foundation; Skane Centre of Excellence in Health; Crown Princess Lovisas Society for Child Care; Konung Gustaf V:s 80-arsfond; Alfred Osterlund Foundation; Wallenberg Center for Molecular Medicine; Swedish Rheumatism Association; Anna-Greta Crafoord Foundation; Greta and Johan Kocks Foundation; Samariten Foundation; Fanny Ekdahl foundation; Jerring foundation; Fondation pour la Recherche MedicaleFondation pour la Recherche Medicale [DEQ20170336759]; Ingrid Asp Foundation; IngaBritt och Arne Lundbergs Research Foundation; Region Skane; Thelma Zoegas Foundation
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- 2019
13. Elucidating in utero fetal demise: time to reassemble the pieces of the puzzle?
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Belhomme, Nicolas, primary, Lescoat, Alain, additional, Ballerie, Alice, additional, Rouget, Florence, additional, Le Bouar, Gwenaelle, additional, Loget, Philippe, additional, Caillault, Leïla, additional, and Jego, Patrick, additional
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- 2019
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14. 31: Congenital toxoplasmosis prevention by pyrimethamine-sulfadiazine vs spiramycin, a randomized trial
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Mandelbrot, Laurent, primary, Villena, Isabelle, additional, Kieffer, Francois, additional, Laurichesse-Delmas, Helene, additional, Winer, Norbert, additional, Mesnard, Louis, additional, Berrebi, Alain, additional, Le Bouar, Gwenaelle, additional, Cordier, Anne-Gaelle, additional, Sitta, Remi, additional, and Thiebaut, Rodolphe, additional
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- 2018
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15. Dépistage prénatal non invasif (DPNI) de la trisomie 21 : bilan d’activité 2016 au centre hospitalier universitaire de Rennes
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Launay, Erika, primary, Nouyou, Bénédicte, additional, Le Bouar, Gwenaelle, additional, Bertorello, Isabelle, additional, D’Hervé, Dominique, additional, Aussel, Dominique, additional, Body-Bechou, Delphine, additional, Biquard, Florence, additional, Martin-Coignard, Dominique, additional, Lucas, Josette, additional, Odent, Sylvie, additional, Jaillard, Sylvie, additional, and Belaud-Rotureau, Marc-Antoine, additional
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- 2017
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16. Elucidating fetal demise: time to reassemble the pieces of the puzzle?
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Belhomme, Nicolas, Lescoat, Alain, Ballerie, Alice, Rouget, Florence, Le Bouar, Gwenaelle, Loget, Philippe, Caillault, Leïla, and Jego, Patrick
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ANTIPHOSPHOLIPID syndrome ,AUTOPSY ,PHOSPHOLIPID antibodies ,ETIOLOGY of diseases ,PERINATAL death - Published
- 2020
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17. Diagnosis of fetal urinary tract malformations: prenatal management and postnatal outcome
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Ryckewaert-D'Halluin, Amélie, Le Bouar, Gwenaelle, Odent, Sylvie, Milon, Joëlle, D'Hervé, Dominique, Lucas, Josette, Rouget, Florence, Loget, Philippe, Poulain, Patrice, Le Gall, Edouard, Taque, Sophie, Service de médecine de l'enfant et de l'adolescent [CHU Rennes], CHU Pontchaillou [Rennes], Service de Gynécologie et Obstétrique [Rennes] = Gynaecology [Rennes], Service de génétique clinique [Rennes], Université de Rennes (UR)-CHU Pontchaillou [Rennes]-hôpital Sud, Clinique mutualiste La Sagesse, Service de Cytogénétique et de Biologie Cellulaire, Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], De Villemeur, Hervé, Service de médecine de l'enfant et de l'adolescent, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service de Génétique Clinique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-hôpital Sud, and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes]
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Adult ,Male ,MESH: Abnormalities, Multiple ,Abnormal Karyotype ,MESH: Amniotic Fluid ,Gestational Age ,MESH: Prognosis ,prenatal renal function ,MESH: Pregnancy ,Pregnancy ,MESH: Gestational Age ,Prenatal Diagnosis ,[SDV.BDD] Life Sciences [q-bio]/Development Biology ,MESH: Urinary Tract ,Humans ,Abnormalities, Multiple ,MESH: Prenatal Diagnosis ,Urinary Tract ,fetal prognosis ,MESH: Prenatal Care ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,Retrospective Studies ,Ultrasonography ,MESH: Humans ,MESH: Child, Preschool ,Pregnancy Outcome ,MESH: Retrospective Studies ,MESH: Adult ,Prenatal Care ,MESH: Pregnancy Outcome ,Amniotic Fluid ,Prognosis ,MESH: Male ,Fetal Diseases ,MESH: Fetal Diseases ,Child, Preschool ,Female ,MESH: Abnormal Karyotype ,fetal urinary tract malformations ,MESH: Female - Abstract
International audience; OBJECTIVE: To evaluate prenatal management and to define the criteria of gravity for accurate assessment of the renal and overall prognosis of fetuses presenting malformations of the urinary tract. METHODS: We carried out a retrospective study of 127 cases of urinary tract malformation. We carried out descriptive statistical and univariate analyses as a function of severity criteria and the outcome of pregnancy. RESULTS: One-third of fetuses presented associated extrarenal malformations and 10% of the karyotypes were abnormal. There were more abortions in case of decrease in amniotic fluid volume (p < 0.001), extent of renal damage (p < 0.05), presence of associated extrarenal malformations (p < 0.05), early diagnosis of the malformation (p < 0.001) and presence of chromosomal syndrome (p = 0.01). In our study, there was an excellent correlation between prenatal data and pathological findings for the fetus following abortions for medical reasons or obtained during the surveillance of live-born children. Fetal biochemistry made very little contribution. CONCLUSION: In cases of urinary tract malformation, this work confirms the need for regular and frequent ultrasound scans, checking for the echographic factors indicative of gravity and for adapted karyotyping. It also demonstrates that pluridisciplinary management is necessary for the prenatal evaluation of renal and overall fetal prognosis.
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- 2011
18. Terminal 6.9 Mb deletion of chromosome 15q, associated with a structurally abnormal X chromosome in a patient with congenital diaphragmatic hernia and heart defect
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Jaillard, Sylvie, Loget, Philippe, Lucas, Josette, Dubourg, Christèle, Le Bouar, Gwenaelle, Demurger, Florence, Bertorello, Isabelle, David, Véronique, Poulain, Patrice, Odent, Sylvie, and Belaud-Rotureau, Marc-Antoine
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- 2011
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19. Uterine rupture during pregnancy following myomectomy via coelioscopy
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Foucher, Fabrice, primary, Levêque, Jean, additional, Le Bouar, Gwenaelle, additional, and Grall, Jean-Yves, additional
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- 2000
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20. Extending the clinical spectrum of X-linked Tonne-Kalscheuer syndrome (TOKAS): new insights from the fetal perspective.
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Cuinat S, Quélin C, Effray C, Dubourg C, Le Bouar G, Cabaret-Dufour AS, Loget P, Proisy M, Sauvestre F, Sarreau M, Martin-Berenguer S, Beneteau C, Naudion S, Michaud V, Arveiler B, Trimouille A, Macé P, Sigaudy S, Glazunova O, Torrents J, Raymond L, Saint-Frison MH, Attié-Bitach T, Lefebvre M, Capri Y, Bourgon N, Thauvin-Robinet C, Tran Mau-Them F, Bruel AL, Vitobello A, Denommé-Pichon AS, Faivre L, Brehin AC, Goldenberg A, Patrier-Sallebert S, Perani A, Dauriat B, Bourthoumieu S, Yardin C, Marquet V, Barnique M, Fiorenza-Gasq M, Marey I, Tournadre D, Doumit R, Nugues F, Barakat TS, Bustos F, Jaillard S, Launay E, Pasquier L, and Odent S
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- Humans, Male, Female, Fetus pathology, Mutation, Phenotype, Prenatal Diagnosis, Exome Sequencing, Genetic Association Studies methods, Abnormalities, Multiple genetics, Abnormalities, Multiple pathology, Abnormalities, Multiple diagnosis, Pedigree, Pregnancy, Genetic Diseases, X-Linked genetics, Genetic Diseases, X-Linked pathology, Genetic Diseases, X-Linked diagnosis
- Abstract
Introduction: Tonne-Kalscheuer syndrome (TOKAS) is a recessive X-linked multiple congenital anomaly disorder caused by RLIM variations. Of the 41 patients reported, only 7 antenatal cases were described., Method: After the antenatal diagnosis of TOKAS by exome analysis in a family followed for over 35 years because of multiple congenital anomalies in five male fetuses, a call for collaboration was made, resulting in a cohort of 11 previously unpublished cases., Results: We present a TOKAS antenatal cohort, describing 11 new cases in 6 French families. We report a high frequency of diaphragmatic hernia (9 of 11), differences in sex development (10 of 11) and various visceral malformations. We report some recurrent dysmorphic features, but also pontocerebellar hypoplasia, pre-auricular skin tags and olfactory bulb abnormalities previously unreported in the literature. Although no clear genotype-phenotype correlation has yet emerged, we show that a recurrent p.(Arg611Cys) variant accounts for 66% of fetal TOKAS cases. We also report two new likely pathogenic variants in RLIM , outside of the two previously known mutational hotspots., Conclusion: Overall, we present the first fetal cohort of TOKAS, describe the clinical features that made it a recognisable syndrome at fetopathological examination, and extend the phenotypical spectrum and the known genotype of this rare disorder., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
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- 2024
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21. Predicting the risk of respiratory distress in newborns with congenital pulmonary malformations.
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Delacourt C, Bertille N, Salomon LJ, Rahshenas M, Benachi A, Bonnard A, Choupeaux L, Fouquet V, Goua V, Hameury F, Hervieux E, Jouannic JM, Khen-Dunlop N, Le Bouar G, Massardier J, Roditis L, Rosenblatt J, Sartor A, Thong-Vanh C, Lelong N, and Khoshnood B
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- Child, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Pregnancy, Prospective Studies, Risk Factors, Respiratory Distress Syndrome, Ultrasonography, Prenatal methods
- Abstract
Objectives: Most children with prenatally diagnosed congenital pulmonary malformations (CPMs) are asymptomatic at birth. We aimed to develop a parsimonious prognostic model for predicting the risk of neonatal respiratory distress (NRD) in preterm and term infants with CPM, based on the prenatal attributes of the malformation., Methods: MALFPULM is a prospective population-based nationally representative cohort including 436 pregnant women. The main predictive variable was the CPM volume ratio (CVR) measured at diagnosis (CVR first) and the highest CVR measured (CVR max). Separate models were estimated for preterm and term infants and were validated by bootstrapping., Results: In total, 67 of the 383 neonates studied (17%) had NRD. For infants born at term (>37 weeks, n=351), the most parsimonious model included CVR max as the only predictive variable (receiver operating characteristic (ROC) curve area: 0.70±0.04, negative predictive value: 0.91). The probability of NRD increased linearly with increasing CVR max and remained below 10% for CVR max <0.4. In preterm infants (n=32), both CVR max and gestational age were important predictors of the risk of NRD (ROC: 0.85±0.07). Models based on CVR first had a similar predictive ability., Conclusions: Predictive models based exclusively on CVR measurements had a high negative predictive value in infants born at term. Our study results could contribute to the individualised general risk assessment to guide decisions about the need for newborns with prenatally diagnosed CPM to be delivered at specialised centres., Competing Interests: Conflict of interest: C. Delacourt has nothing to disclose. Conflict of interest: N. Bertille has nothing to disclose. Conflict of interest: L.J. Salomon has nothing to disclose. Conflict of interest: M. Rahshenas has nothing to disclose. Conflict of interest: A. Benachi has nothing to disclose. Conflict of interest: A. Bonnard has nothing to disclose. Conflict of interest: L. Choupeaux has nothing to disclose. Conflict of interest: V. Fouquet has nothing to disclose. Conflict of interest: V. Goua has nothing to disclose. Conflict of interest: F. Hameury has nothing to disclose. Conflict of interest: E. Hervieux has nothing to disclose. Conflict of interest: J-M. Jouannic has nothing to disclose. Conflict of interest: N. Khen-Dunlop has nothing to disclose. Conflict of interest: G. Le Bouar has nothing to disclose. Conflict of interest: J. Massardier has nothing to disclose. Conflict of interest: L. Roditis has nothing to disclose. Conflict of interest: J. Rosenblatt has nothing to disclose. Conflict of interest: A. Sartor has nothing to disclose. Conflict of interest: C. Thong-Vanh has nothing to disclose. Conflict of interest: N. Lelong has nothing to disclose. Conflict of interest: B. Khoshnood has nothing to disclose., (Copyright ©The authors 2022. For reproduction rights and permissions contact permissions@ersnet.org.)
- Published
- 2022
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22. Elucidating in utero fetal demise: time to reassemble the pieces of the puzzle?
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Belhomme N, Lescoat A, Ballerie A, Rouget F, Le Bouar G, Loget P, Caillault L, and Jego P
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- Humans, Fetal Death
- Published
- 2020
- Full Text
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