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1. Advanced Systemic Treatments in Patients with Moderate-to-Severe Atopic Dermatitis: Key Learnings from Physicians Practicing in Nine Asian Countries and Territories

Author

Chia-Yu Chu, Ramesh Bhat Marne, Christina Man-Tung Cheung, Le Ngoc Diep, Nopadon Noppakun, Endi Novianto, Maria Lourdes H. Palmero, Yong-Kwang Tay, and Azizan Noor Zalmy

Subjects
Antirheumatic agents, Asia, Biologics, Dermatitis, Atopic, Janus kinase inhibitors, Dermatology, RL1-803
Abstract

Abstract Introduction Rapid progress made in the management of atopic dermatitis (AD) in recent years and the differences in patient journey between Asian and non-Asian populations call for a review of current atopic dermatitis landscape in Asia. Methods A roundtable meeting with nine regional dermatological experts was held in June 2023 to discuss the optimal management approaches for moderate-to-severe AD, focusing on the use of advanced therapies. Results Disease burden on patients’ quality of life, treatment adherence, and financial constraints were identified as major concerns when managing patients with moderate-to-severe AD in parts of Asia. It was agreed that the Hanifin and Rajka’s criteria or the UK Working Party’s Diagnostic Criteria for Atopic Dermatitis can be used to guide the clinical diagnosis of AD. Meanwhile, patient-reported outcome scales including the Dermatology Life Quality Index and Atopic Dermatitis Control Tool can be used alongside depression monitoring scales to monitor treatment outcomes in patients with AD, allowing a better understanding for individualized treatment. When managing moderate-to-severe AD, phototherapy should be attempted after failure with topical treatments, followed by conventional disease-modifying antirheumatic drugs and, subsequently, biologics or Janus kinase inhibitors. Systemic corticosteroids can be used as short-term therapy for acute flares. Although these advanced treatments are known to be effective, physicians have to take into consideration safety concerns and limitations when prescribing these treatments. Conclusions Treatments in AD have evolved and its management varies country by country. Unique challenges across Asian countries necessitate a different management approach in Asian patients with AD.

Published
2024
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5. Chemical composition and antimicrobial activity of the essential oil from \(\textit{Magnolia balansae}\) A. DC. growing in Vietnam

Author

Chu Thị Thu Hà, Tran Huy Thai, Nguyen Thi Hien, Le Ngoc Diep, and Dinh Thi Thu Thuy

Subjects
Psychiatry and Mental health
Abstract

Essential oils of Magnolia balansae A. DC. growing wild in Son La (leaf, twig and fruit) and Phu Tho (fruit) provinces of Vietnam were obtained by hydrodistillation and were analyzed using GC/MS-FID. From 30 to 49 compounds were identified accounting for 66.1–80.0% of the oils. Spathulenol (33.9%, 20.7%, and 11.2%), and caryophyllene oxide (10.0%, 10.1%, and 9.3%) were the main components of leaf, twig and fruit oils of M. balansae, respectively, from Son La province. Linalool (13.8%) was also the main component of fruit oil. While, in the fruit oil of M. balansae from Phu Tho province, cis-β-elemene (10.4%) was the sole main component. The antimicrobial activity of the oils was tested against 3 microorganism strains using an agar disk diffusion method with inhibitory zone diameters ranging from 13.5 to 40 mm. IC50 and MIC of the M. balansae oils were determined using a microdilution broth susceptibility assay against 7 microorganism strains. Among them, Bacillus subtilis had the highest sensitivity with IC50 values (ranging from 57.0 to 82.0 µg/mL) and MIC value (512 µg/mL). This is the first study on the chemical composition of essential oils of M. balansae and their antimicrobial activity.

Published
2022
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9. CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF THE ESSENTIAL OIL FROM Magnolia balansae A. DC. GROWING IN VIETNAM.

Author

Chu Thi Thu Ha, Tran Huy Thai, Nguyen Thi Hien, Le Ngoc Diep, and Dinh Thi Thu Thuy

Abstract

Essential oils of Magnolia balansae A. DC. growing wild in Son La (leaf, twig and fruit) and Phu Tho (fruit) provinces of Vietnam were obtained by hydrodistillation and were analyzed using GC/MS-FID. From 30 to 49 compounds were identified accounting for 66.1-80.0% of the oils. Spathulenol (33.9%, 20.7%, and 11.2%), and caryophyllene oxide (10.0%, 10.1%, and 9.3%) were the main components of leaf, twig and fruit oils of M. balansae, respectively, from Son La province. Linalool (13.8%) was also the main component of fruit oil. While, in the fruit oil of M. balansae from Phu Tho province, cis-ß-elemene (10.4%) was the sole main component. The antimicrobial activity of the oils was tested against 3 microorganism strains using an agar disk diffusion method with inhibitory zone diameters ranging from 13.5 to 40 mm. IC50 and MIC of the M. balansae oils were determined using a microdilution broth susceptibility assay against 7 microorganism strains. Among them, Bacillus subtilis had the highest sensitivity with IC50 values (ranging from 57.0 to 82.0 µg/mL) and MIC value (512 µg/mL). This is the first study on the chemical composition of essential oils of M. balansae and their antimicrobial activity. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Chemical composition of essential oil from the leaves of Amentotaxus yunnanensis H.L. Li in Ha Giang province

Author

Tran Huy Thai, Dinh Thi Thu Thuy, Nguyen Trung Thành, Nguyen Thi Hien, and Le Ngoc Diep

Subjects
biology, Chemistry, law, Botany, biology.organism_classification, Chemical composition, Amentotaxus yunnanensis, Essential oil, law.invention
Abstract

The essential oil from the leaves of the Amentotaxus yunnanensis collected in Hoang Su Phi, Ha Giang province was obtained by hydrodistillation using a Clevenger apparatus and the yield of the essential oil was 0.01% from air-dry material. By using GC/MS analysis 50 constituents were identified, accounting for 88.96% of the essential oil. The main constituents were α-pinene (21.91%), kaur-16-ene (13.03%), α-calacorene (9.42%), δ-cadinene (6.23%) and β-caryophyllene (4.9%). This is the first study on the chemical constituents of essential oils from the leaves of Amentotaxus yunnanensis in Vietnam. Keywords: essential oil, Amentotaxus yunnanensis, α-pinene, kaur-16-ene, α-calacorene, δ-cadinene.

Published
2020
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11. Chemical composition and antimicrobial activity of the essential oil from twigs and leaves of Magnolia macclurei (Dandy) Figlar from Ha Giang Province, Vietnam

Author

Dinh Thi Thu Thuy, Le Ngoc Diep, Tran Huy Thai, Ha Minh Tam, Chu Thi Thu Ha, and Nguyen Duc Ky

Subjects
Horticulture, law, Biology, Antimicrobial, Chemical composition, Essential oil, law.invention
Abstract

The chemical composition of the essential oil obtained by hydrodistillation of the twigs and leaves of Magnolia macclurei collected in Hoang Su Phi, Ha Giang Province, Vietnam was analyzed using GC/MS. A total of 38 compounds were detected in essential oil, accounting for 94.49% of the oil, in which 37 compounds were identified accounting for 93.33%. cis-β-Elemene (14,30%), bicyclogermacrene (18,57%), and 10-epi-ᵧ-eudesmol (16,86%) were the main components of essential oil. The minor components present with rather high amount were: Germacrene D (2,12%), guaiol (8,52%), hinesol (2,34%), valerianol (6,76%), and bulnesol (2,93%). Antibiotic activity of the essential oil sample was tested against a Gram positive bacteria Staphylococcus aureus, a Gram negative bacteria Escherichia coli, and a yeast Candida albicans using an agar disk diffusion method. All three microorganisms tested are resistant to the oil from twigs and leaves of M. macclurei. That is exhibited through the inhibitory zone diameters ranging from 4 to 12 mm.

Published
2020
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13. Chemical Composition of Needle, Cone, and Branch Oils From Vietnamese Pinus cernua

Author

Nguyen Thi Hien, Mathieu Paoli, Tran Hui Thai, Joseph Casanova, Le Ngoc Diep, Félix Tomi, Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Sciences pour l'environnement (SPE), and Centre National de la Recherche Scientifique (CNRS)-Université Pascal Paoli (UPP)

Subjects
Pharmacology, 010405 organic chemistry, Vietnamese, Plant Science, General Medicine, Biology, 01 natural sciences, Cone (formal languages), language.human_language, 0104 chemical sciences, %22">Pinus , 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, Synonym (taxonomy), [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Drug Discovery, Botany, language, Chemical composition, ComputingMilieux_MISCELLANEOUS
Abstract

Conifers are well represented in Vietnam where a new pine species has been recently discovered in Son La province: Pinus cernua, synonym P. armandii ssp. xuannhaensis. The compositions of needle, cone, and branch oils have been investigated by gas chromatography (retention index), gas chromatography-mass spectrometry, and 13C nuclear magnetic resonance. Myrcene (47.0%) was the main component of needle oil, followed by β-pinene (28.4%) and α-pinene (12.5%). Branch oil also contained myrcene (32.8%), α-pinene (17.9%), β-pinene (9.8%), and a high content of limonene (20.0%). Finally, cone oil displayed α-pinene (44.1%) beside myrcene (11.5%), β-pinene (8.1%), and limonene (5.8%).

Published
2019
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14. Effectiveness, Safety and Tolerance of Methotrexate in Vietnamese Psoriatic Arthritis Patients

Author

Bui Thi, Van, primary, Ngo Minh, Vinh, additional, Tran Ngoc, Anh, additional, Tran Dang, Quyet, additional, Le Ngoc, Diep, additional, Dang Van, Em, additional, Nguyen Van, Thuong, additional, Thi Minh, Phuong Pham, additional, Thi Thu, Hien Do, additional, Dinh Huu, Nghi, additional, Le Huyen, My, additional, Tran Hau, Khang, additional, Gandolfi, Marco, additional, Satolli, Francesca, additional, Feliciani, Claudio, additional, Tirant, Michael, additional, Vojvodic, Aleksandra, additional, and Lotti, Torello, additional

Published
2019
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15. In Vitro Antibiotic Resistance in Bacterial Infected Eczema at Ho Chi Minh City Hospital of Dermatology

Author

Le Ngoc, Diep, primary, Nguyen Thi Vu, Ly, additional, Chau Van, Tro, additional, Ngo Minh, Vinh, additional, Nguyen Trong, Hao, additional, Nguyen Van, Thuong, additional, Tran Hau, Khang, additional, Gandolfi, Marco, additional, Satolli, Francesca, additional, Feliciani, Claudio, additional, Tirant, Michael, additional, Vojvodic, Aleksandra, additional, Thi Bich, Na Pham, additional, and Lotti, Torello, additional

Published
2019
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16. Loropetalum flavum (Hamamelidaceae), a new species from northern Vietnam

Author

Le Ngoc Diep, Khang Sinh Nguyen, Peter K. Endress, Tatiana V. Maisak, Leonid V. Averyanov, Anna L. Averyanova, Tran Huy Thai, University of Zurich, and Averyanov, Leonid V

Subjects
0301 basic medicine, Gynoecium, Ecology, Indumentum, biology, Evolution, Ovary (botany), Plant Science, 580 Plants (Botany), biology.organism_classification, Plant taxonomy, 10121 Department of Systematic and Evolutionary Botany, 03 medical and health sciences, Hamamelidaceae, 1105 Ecology, Evolution, Behavior and Systematics, 030104 developmental biology, Behavior and Systematics, Inflorescence, Loropetalum, 1110 Plant Science, Botany, 10211 Zurich-Basel Plant Science Center, Perianth, Ecology, Evolution, Behavior and Systematics
Abstract

Loropetalum flavum (Hamamelidaceae) is described and illustrated as a new species from Bat Dai Son Mountains situated in the northern Vietnam. Recently discovered plant was observed as a typical element of the rich primary forest found on the highly eroded karstic limestone mountain formations allied to the border with China. The new species is characterized by arboreous habit; stellately indumentum of branchlets, leaves and flowers; axillary, capitate, 4–12-flowered inflorescences; yellow, sessile, actinomorphic, bisexual, 4–6-merous flowers with 2-whorled perianth and 2–8 fleshy disc lobes; stamens with conspicuous subulate connective protrusion; anthers with 2 rectangular 2-sporangiate thecae, each dehiscing by 2 valves and syncarpous gynoecium with 2-locular inferior ovary bearing 2 very short separate styles. A key to all known species of Loropetalum species is given and lectotype of L. lanceum is proposed.

Published
2018
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17. CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF THE ESSENTIAL OILS FROM STEMS AND LEAVES OF Michelia alba D.C. GROWING IN VIETNAM.

Author

Chu Thi Thu Ha, Tran Huy Thai, Le Ngoc Diep, Trinh Xuan Thanh, Dinh Thi Thu Thuy, Nguyen Thanh Tra, and Nguyen Thi Thu Ha

Subjects
ESSENTIAL oils, CHEMICAL composition of plants, ANTI-infective agents, LINALOOL, BORNEOLS, CARYOPHYLLENE, HUMULENE, ANTIBIOTICS
Abstract

The chemical composition of the essential oils obtained by hydrodistillation of the stems and leaves of Michelia alba D.C. growing in North Vietnam was analyzed using GC/MS. In total, 28 com¬pounds were identified in both stem and leaf oils, accounting for 99.33% and 99.54% of the oils, respectively. Linalool was the major component of both oils (80.65% and 72.89%, respectively), and other 22 compounds were also present as the constituents of both oils with varying amounts except 1,10-di-epi-cubenol present only in stem oil, whereas borneol (=endo-borneol), α-copaene, α-selinene and ethyl 2-phenylhexanoate were found only in leaf oil. In the stem oil, (Z)-β-ocimene (1.94%), (E)-β-ocimene (2.28%), β-caryophyllene (1.26%), (E)-nerolidol (1.15%), caryophyllene oxide (2.26%) and epi-α-muurolol (=T-muurolol) (1.80%) were present in sizeable amounts. The minor components detected in the leaf oil were (Z)-β-ocimene (1.73%), (E)-β-ocimene (2.28%), Cis-β-elemene (3.03%), P-caryophyllene (4.04%), α α-humulene (1.44%), (E)-nerolidol (4.42%) and caryophyllene oxide (1.36%). Antibiotic activity of the essential oil samples was tested against Gram positive bacteria Staphylococcus aureus, Gram negative bacteria Escherichia coli, and yeast Candida albican using an agar disk diffusion method. The antimicrobial activity of leaf oil was stronger than that of stem oil, although both oils have significant inhibitory activity against all three microorganisms tested with the inhibitory zone diameters ranging from 15.5 to 46.5 mm. [ABSTRACT FROM AUTHOR]

Published
2018
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18. Customer Satisfaction in Online Banking : A Comparative Study of Local and Foreign Commercial Banks in the South of Vietnam, Ho Chi Minh City

Author

Nguyen, Le Ngoc Diep and Nguyen, Le Ngoc Diep

Abstract

The purpose of this research is to construct a conceptual model with related instruments that affect customer satisfaction in using online banking in Ho Chi Minh City and Southern Vietnam. An important task of this work is the comparison of customer satisfaction in using online banking between customers of Vietnamese local banks and customers of foreign banks. Further discussions of the relationship among online service quality, perceived value, e-trust, relationship quality, customer satisfaction and customer loyalty are included. The results show that Vietnamese people are ethnocentric because there are 74% among 309 respondents currently using personal banking account of a Vietnam local bank. Exploratory analysis and regression analysis are made using SPSS for the observation of relationships between proposed factors. Respondents involved in the survey (quantitative method) are volunteers selected randomly while making sure that all of them are currently having personal banking accounts and have standard knowledge of using online banking. There are altogether 12 hypotheses in the proposed research model. The main findings of this work are: (1) Service quality positively influences perceived value; (2) Service quality positively influences e-trust; (3) Service quality positively influences customer satisfaction; (4) Perceived value positively influences e-trust; (5) E-trust positively influences customer satisfaction; (6) Perceived value positively influences loyalty; (7) Customer satisfaction positively loyalty; (8) Relationship positively influences e-trust; (9) Relationship quality positively influences customer satisfaction. Notice that the findings are especially for Vietnam online banking sector at Ho Chi Minh City.

19. Customer Satisfaction in Online Banking : A Comparative Study of Local and Foreign Commercial Banks in the South of Vietnam, Ho Chi Minh City

Author

Nguyen, Le Ngoc Diep and Nguyen, Le Ngoc Diep

Abstract

The purpose of this research is to construct a conceptual model with related instruments that affect customer satisfaction in using online banking in Ho Chi Minh City and Southern Vietnam. An important task of this work is the comparison of customer satisfaction in using online banking between customers of Vietnamese local banks and customers of foreign banks. Further discussions of the relationship among online service quality, perceived value, e-trust, relationship quality, customer satisfaction and customer loyalty are included. The results show that Vietnamese people are ethnocentric because there are 74% among 309 respondents currently using personal banking account of a Vietnam local bank. Exploratory analysis and regression analysis are made using SPSS for the observation of relationships between proposed factors. Respondents involved in the survey (quantitative method) are volunteers selected randomly while making sure that all of them are currently having personal banking accounts and have standard knowledge of using online banking. There are altogether 12 hypotheses in the proposed research model. The main findings of this work are: (1) Service quality positively influences perceived value; (2) Service quality positively influences e-trust; (3) Service quality positively influences customer satisfaction; (4) Perceived value positively influences e-trust; (5) E-trust positively influences customer satisfaction; (6) Perceived value positively influences loyalty; (7) Customer satisfaction positively loyalty; (8) Relationship positively influences e-trust; (9) Relationship quality positively influences customer satisfaction. Notice that the findings are especially for Vietnam online banking sector at Ho Chi Minh City.

20. Customer Satisfaction in Online Banking : A Comparative Study of Local and Foreign Commercial Banks in the South of Vietnam, Ho Chi Minh City

Author

Nguyen, Le Ngoc Diep and Nguyen, Le Ngoc Diep

Abstract

The purpose of this research is to construct a conceptual model with related instruments that affect customer satisfaction in using online banking in Ho Chi Minh City and Southern Vietnam. An important task of this work is the comparison of customer satisfaction in using online banking between customers of Vietnamese local banks and customers of foreign banks. Further discussions of the relationship among online service quality, perceived value, e-trust, relationship quality, customer satisfaction and customer loyalty are included. The results show that Vietnamese people are ethnocentric because there are 74% among 309 respondents currently using personal banking account of a Vietnam local bank. Exploratory analysis and regression analysis are made using SPSS for the observation of relationships between proposed factors. Respondents involved in the survey (quantitative method) are volunteers selected randomly while making sure that all of them are currently having personal banking accounts and have standard knowledge of using online banking. There are altogether 12 hypotheses in the proposed research model. The main findings of this work are: (1) Service quality positively influences perceived value; (2) Service quality positively influences e-trust; (3) Service quality positively influences customer satisfaction; (4) Perceived value positively influences e-trust; (5) E-trust positively influences customer satisfaction; (6) Perceived value positively influences loyalty; (7) Customer satisfaction positively loyalty; (8) Relationship positively influences e-trust; (9) Relationship quality positively influences customer satisfaction. Notice that the findings are especially for Vietnam online banking sector at Ho Chi Minh City.

21. Customer Satisfaction in Online Banking : A Comparative Study of Local and Foreign Commercial Banks in the South of Vietnam, Ho Chi Minh City

Author

Nguyen, Le Ngoc Diep and Nguyen, Le Ngoc Diep

Abstract

The purpose of this research is to construct a conceptual model with related instruments that affect customer satisfaction in using online banking in Ho Chi Minh City and Southern Vietnam. An important task of this work is the comparison of customer satisfaction in using online banking between customers of Vietnamese local banks and customers of foreign banks. Further discussions of the relationship among online service quality, perceived value, e-trust, relationship quality, customer satisfaction and customer loyalty are included. The results show that Vietnamese people are ethnocentric because there are 74% among 309 respondents currently using personal banking account of a Vietnam local bank. Exploratory analysis and regression analysis are made using SPSS for the observation of relationships between proposed factors. Respondents involved in the survey (quantitative method) are volunteers selected randomly while making sure that all of them are currently having personal banking accounts and have standard knowledge of using online banking. There are altogether 12 hypotheses in the proposed research model. The main findings of this work are: (1) Service quality positively influences perceived value; (2) Service quality positively influences e-trust; (3) Service quality positively influences customer satisfaction; (4) Perceived value positively influences e-trust; (5) E-trust positively influences customer satisfaction; (6) Perceived value positively influences loyalty; (7) Customer satisfaction positively loyalty; (8) Relationship positively influences e-trust; (9) Relationship quality positively influences customer satisfaction. Notice that the findings are especially for Vietnam online banking sector at Ho Chi Minh City.

22. Customer Satisfaction in Online Banking : A Comparative Study of Local and Foreign Commercial Banks in the South of Vietnam, Ho Chi Minh City

Author

Nguyen, Le Ngoc Diep and Nguyen, Le Ngoc Diep

Abstract

The purpose of this research is to construct a conceptual model with related instruments that affect customer satisfaction in using online banking in Ho Chi Minh City and Southern Vietnam. An important task of this work is the comparison of customer satisfaction in using online banking between customers of Vietnamese local banks and customers of foreign banks. Further discussions of the relationship among online service quality, perceived value, e-trust, relationship quality, customer satisfaction and customer loyalty are included. The results show that Vietnamese people are ethnocentric because there are 74% among 309 respondents currently using personal banking account of a Vietnam local bank. Exploratory analysis and regression analysis are made using SPSS for the observation of relationships between proposed factors. Respondents involved in the survey (quantitative method) are volunteers selected randomly while making sure that all of them are currently having personal banking accounts and have standard knowledge of using online banking. There are altogether 12 hypotheses in the proposed research model. The main findings of this work are: (1) Service quality positively influences perceived value; (2) Service quality positively influences e-trust; (3) Service quality positively influences customer satisfaction; (4) Perceived value positively influences e-trust; (5) E-trust positively influences customer satisfaction; (6) Perceived value positively influences loyalty; (7) Customer satisfaction positively loyalty; (8) Relationship positively influences e-trust; (9) Relationship quality positively influences customer satisfaction. Notice that the findings are especially for Vietnam online banking sector at Ho Chi Minh City.

23. Cu and Zn promoted Al-fumarate metal organic frameworks for electrocatalytic CO 2 reduction.

Author

Dieu Thuy UT, Huan TN, Zanna S, Wilson K, Lee AF, Le ND, Mensah J, Dasireddy VDBC, and Liem NQ

Abstract

Metal organic frameworks (MOFs) are attractive materials to generate multifunctional catalysts for the electrocatalytic reduction of CO 2 to hydrocarbons. Here we report the synthesis of Cu and Zn modified Al-fumarate (Al-fum) MOFs, in which Zn promotes the selective reduction of CO 2 to CO and Cu promotes CO reduction to oxygenates and hydrocarbons in an electrocatalytic cascade. Cu and Zn nanoparticles (NPs) were introduced to the Al-fum MOF by a double solvent method to promote in-pore metal deposition, and the resulting reduced Cu-Zn@Al-fum drop-cast on a hydrophobic gas diffusion electrode for electrochemical study. Cu-Zn@Al-fum is active for CO 2 electroreduction, with the Cu and Zn loading influencing the product yields. The highest faradaic efficiency (FE) of 62% is achieved at -1.0 V vs. RHE for the conversion of CO 2 into CO, HCOOH, CH 4 , C 2 H 4 and C 2 H 5 OH, with a FE of 28% to CH 4 , C 2 H 4 and C 2 H 5 OH at pH 6.8. Al-fum MOF is a chemically robust matrix to disperse Cu and Zn NPs, improving electrocatalyst lifetime during CO 2 reduction by minimizing transition metal aggregation during electrode operation., Competing Interests: There are no conflicts of interest to declare., (This journal is © The Royal Society of Chemistry.)

Published
2024
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