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11 results on '"Le Page, Gareth"'

1. Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

Author

Ducrot, Virginie, Askem, Clare, Azam, Didier, Brettschneider, Denise, Brown, Rebecca, Charles, Sandrine, Coke, Maïra, Collinet, Marc, Delignette-Muller, Marie-Laure, Forfait-Dubuc, Carole, Holbech, Henrik, Hutchinson, Thomas, Jach, Arne, Kinnberg, Karin L., Lacoste, Cédric, Le Page, Gareth, Matthiessen, Peter, Oehlmann, Jörg, Rice, Lynsey, Roberts, Edward, Ruppert, Katharina, Davis, Jessica Elphinstone, Veauvy, Clemence, Weltje, Lennart, Wortham, Ruth, and Lagadic, Laurent

Published
2014
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6. Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda)

Author

Ruppert, Katharina, primary, Geiß, Cornelia, additional, Askem, Clare, additional, Benstead, Rachel, additional, Brown, Rebecca, additional, Coke, Maira, additional, Ducrot, Virginie, additional, Egeler, Philipp, additional, Holbech, Henrik, additional, Hutchinson, Thomas H., additional, Kinnberg, Karin L., additional, Lagadic, Laurent, additional, Le Page, Gareth, additional, Macken, Ailbhe, additional, Matthiessen, Peter, additional, Ostermann, Sina, additional, Schimera, Agnes, additional, Schmitt, Claudia, additional, Seeland-Fremer, Anne, additional, Smith, Andy J., additional, Weltje, Lennart, additional, and Oehlmann, Jörg, additional

Published
2017
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9. Are Toxicological Responses in Laboratory (Inbred) Zebrafish Representative of Those in Outbred (Wild) Populations? − A Case Study with an Endocrine Disrupting Chemical

Author

Brown, A. Ross, primary, Bickley, Lisa K., additional, Le Page, Gareth, additional, Hosken, David John, additional, Paull, Gregory C., additional, Hamilton, Patrick B., additional, Owen, Stewart F., additional, Robinson, Joanna, additional, Sharpe, Alan D., additional, and Tyler, Charles R., additional

Published
2011
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10. Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish.

Author

Bickley, Lisa K., Brown, Andrew R., Hosken, David J., Hamilton, Patrick B., Le Page, Gareth, Paull, Gregory C., Owen, Stewart F., and Tyler, Charles R.

Subjects
INBREEDING, FISH reproduction, FISH as laboratory animals, POLLUTION, FUNGICIDES
Abstract

Inbreeding depression is expected to be more severe in stressful environments. However, the extent to which inbreeding affects the vulnerability of populations to environmental stressors, such as chemical exposure, remains unresolved. Here we report on the combined impacts of inbreeding and exposure to an endocrine disrupting chemical (the fungicide clotrimazole) on zebrafish (Danio rerio). We show that whilst inbreeding can negatively affect reproductive traits, not all traits are affected equally. Inbreeding depression frequently only became apparent when fish were additionally stressed by chemical exposure. Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer offspring when in direct competition with outbred individuals. Levels of plasma 11-ketotestosterone, a key male sex hormone, showed substantial inbreeding depression that was unaffected by addition of the fungicide. In contrast, there was no effect of inbreeding or clotrimazole exposure on egg production. Overall, our data provide evidence that stress may amplify the effects of inbreeding on key reproductive traits, particularly those associated with male fitness. This may have important implications when considering the consequences of exposure to chemical pollutants on the fitness of wild populations. [ABSTRACT FROM AUTHOR]

Published
2013
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