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SummaryFccRIIB, a low affinity receptor for the Fc portion of immunoglobulin G(IgG), is thought to drive negative selection of B cells in germinal centers(GC) by inducing apoptosis upon interaction with immune complexes. Itsexpression was investigated by immunohistochemistry in 22 reactivelymphoid tissues and 112 B-cell lymphomas. Pre-GC mantle cells, marginalzone cells and their neoplastic counterparts expressed FccRIIB. The B chroniclymphocytic leukaemia (B-CLL)/small lymphocytic lymphomas were alsopositive. Not detected in GC, FccRIIB was expressed in 52% of follicularlymphomas and in 20% of diffuse large B cell lymphomas (DLBCL). InDLBCL, FccRIIB expression was linked to transformation (P

FcgammaRIIB, a low affinity receptor for the Fc portion of immunoglobulin G (IgG), is thought to drive negative selection of B cells in germinal centers (GC) by inducing apoptosis upon interaction with immune complexes. Its expression was investigated by immunohistochemistry in 22 reactive lymphoid tissues and 112 B-cell lymphomas. Pre-GC mantle cells, marginal zone cells and their neoplastic counterparts expressed FcgammaRIIB. The B chronic lymphocytic leukaemia (B-CLL)/small lymphocytic lymphomas were also positive. Not detected in GC, FcgammaRIIB was expressed in 52% of follicular lymphomas and in 20% of diffuse large B cell lymphomas (DLBCL). In DLBCL, FcgammaRIIB expression was linked to transformation (P0.001). Re-analysis of a gene profile data set from the Lymphochip microarrays showed that FcgammaRIIB expression in the activated B-like DLBCL subgroup was higher than in the GC-like one (P0.04), and was associated with an adverse prognostic both in univariate (P0.003) and in multivariate analysis including the International Prognostic Indicator (IPI) (P0.01). Thus these results challenge the potential role of FcgammaRIIB during B-cell selection in GC, and suggest a prognostic value of FcgammaRIIB expression in DLBCL.