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AFTER THE FLYING SAUCERS CAME The global history of the UFO phenomenon GREG EGHIGIAN 400pp. Oxford University Press. 22.99 [pounds sterling] ($29.99). IMMINENT Inside the Pentagon's hunt for UFOs LUIS [...]

TASMANIA PAOLO GIORDANO Translated by Anthony Shugaar 384pp. Other Press. Paperback, 17.99 [pounds sterling] (US $18.99). In his latest novel, Tasmania, Paolo Giordano doesn't even wait for the first act [...]

SPACE The human story TIM PEAKE 336pp. Century. 22 [pounds sterling]. THE SIX The untold story of America's first women astronauts LOREN GRUSH 432pp. Virago. 25 [pounds sterling]. Writing in [...]

ON THE ORIGIN OF TIME Stephen Hawking's final theory THOMAS HERTOG 352pp. Torva. 20 [pounds sterling]. WHEN STEPHEN HAWKING told his agent that he wanted his new book to be [...]

THE BOOK OF MARS An anthology of fact and fiction STUART CLARK 896pp. Apollo. 30 [pounds sterling]. Last night, when the clouds cleared for a brief spell, I opened the [...]

Guaianolides are pharmaceutically interesting molecules. Here, the authors isolate the enzyme kauniolide synthase from feverfew, show that it converts constunolide into a guaianolide via an unusual mechanism of action, and reconstruct the full kauniolide biosynthesis pathway in host organisms.

THE EXPERIENCE MACHINE How our minds predict and shape reality ANDY CLARK 304pp. Allen Lane. 25 [pounds sterling]. WHEN PABLO PICASSO said 'I don't paint what I see, I paint [...]

THE MANIAC BENJAMIN LABATUT 368pp. Pushkin Press. 20 [pounds sterling]. BENJAMIN LABATUT'S NOVEL Un verdor terrible (When We Cease to Understand the World, 2020) had already made it on to [...]

THE BRAIN IN SEARCH OF ITSELF Santiago Ramon y Cajal and the story of the neuron BENJAMIN EHRLICH 464pp. Farrar, Straus and Giroux. 27.99 [pounds sterling] (US $35). When Samuel [...]

Over recent decades, an extensive array of anthropogenic chemicals have entered the environment and have been implicated in the increased incidence of an array of diseases, including metabolic syndrome. The ubiquitous presence of these environmental chemicals (ECs) necessitates the use of real‐life exposure models to the assess cumulative risk burden to metabolic health. Sheep that graze on biosolids‐treated pastures are exposed to a real‐life mixture of ECs such as phthalates, per‐ and polyfluoroalkyl substances, heavy metals, pharmaceuticals, pesticides, and metabolites thereof, and this EC exposure can result in metabolic disorders in their offspring. Using this model, we evaluated the effects of gestational exposure to a complex EC mixture on plasma triglyceride (TG) concentrations and metabolic and epigenetic regulatory genes in tissues key to energy regulation and storage, including the hypothalamus, liver, and adipose depots of 11‐month‐old male offspring. Our results demonstrated a binary effect of EC exposure on gene expression particularly in the hypothalamus. Principal component analysis revealed two subsets (B‐S1 [n = 6] and B‐S2 [n = 4]) within the biosolids group (B, n = 10), relative to the controls (C, n = 11). Changes in body weight, TG levels, and in gene expression in the hypothalamus, and visceral and subcutaneous fat were apparent between biosolid and control and the two subgroups of biosolids animals. These findings demonstrate that gestational exposure to an EC mixture results in differential regulation of metabolic processes in adult male offspring. Binary effects on hypothalamic gene expression and altered expression of lipid metabolism genes in visceral and subcutaneous fat, coupled with phenotypic outcomes, point to differences in individual susceptibility to EC exposure that could predispose vulnerable individuals to later metabolic dysfunction. [ABSTRACT FROM AUTHOR]

THE MOUNTAIN IN THE SEA RAY NAYLER 464pp. Weidenfeld and Nicolson. 16.99 [pounds sterling]. IN 1950 the physicist Enrico Fermi was talking about UFOs over lunch at Los Alamos when [...]

THE SINGULARITIES JOHN BANVILLE 320pp. Knopf. 14.99 [pounds sterling] (US $30). JOHN BANVILLE opens his latest novel, The Singularities, with a pun and a question: 'Yes, he has finished his [...]

THE REASON FOR THE DARKNESS OF THE NIGHT Edgar Allan Poe and the forging of American science JOHN TRESCH 448pp. Farrar, Straus and Giroux. $30. Looking back on his literary [...]

THE STARTUP WIFE TAHMIMA ANAM 304pp. Canongate. 14.95 [pounds sterling]. THE OTHER BLACK GIRL ZAKIYA DALILA HARRIS 368pp. Bloomsbury. 14.99 [pounds sterling]. BLACK BUCK MATEO ASKARIPOUR 400pp. John Murray. 14.99 [...]

ATOMS AND ASHES From Bikini Atoll to Fukushima SERHII PLOKHY 368pp. Allen Lane. 25 [pounds sterling]. Launching his new energy strategy in front of the scaffolding at Hinkley Point C [...]

THIS WAY TO THE UNIVERSE A journey into physics MICHAEL DINE 352pp. Viking. 20 [pounds sterling]. It may have a boring name, but the standard model of particle physics is [...]

IN THE PINES PAUL SCRATON 126pp. Influx. Paperback, 8.99 [pounds sterling]. The forest has long been figured as a place of freedom, danger and enchantment, a wilderness beyond civilization. But, [...]

PALMARES GAYL JONES 512pp. Virago. 18.99 [pounds sterling]. Halfway through Gayl Jones's long-awaited novel Palmares--her first in more than twenty years--the narrator Almeyda meets a young Brazilian author who is [...]