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1. Predictive value of the ‘DICA’ classification on the outcome of diverticular disease of the colon: 2.14

Author

Tursi, A., Brandimarte, G., Di Mario, F., Annunziata, M. L., Bianco, M. A., Conigliaro, R., Elisei, W., Faggiani, R., Forti, G., Lecca, P. G., Penna, A., Spadaccini, A., Zampaletta, C., Colucci, R., De Bastiani, R., Di Cesare, L., Di Fonzo, M., Goni, E., Ferrini, L., Graziani, M. G., Latella, G., Pigò, F., Rotondano, G., Schiaccianoce, G., Picchio, M., Scarpignato, C., and Portincasa, P.

Published
2015

2. The DICA Endoscopic Classification for Diverticular Disease of the Colon Shows a Significant Interobserver Agreement among Community Endoscopists: an International Study

Author

Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G. A., Biondi A., Biondo S., Cassieri C., Crucitti A., Dumitrascu D. L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P. G., Maconi G., Malfertheiner P., Mazzarri A., Mearin F., Milosavljevic T., Nardone G., de Oliveira E. C., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L. L., Walker M. M. D., Allegretta L., Altavilla N., Amaro P., Annunziata M. L., Barberio F., Basile G., Bedogni G., Belfiori V., Benvenuti S., Bertolami C., Bisello M., El Dammak M. B., Bozzi R., Buono M., Cambie G., Capezzuto E., Casamassima C., Chavoushian A., Ciofani R., Citarella C., Compare D., Cotruta B., D'amico F., Dulk M. D., Dyrda B. E., Festa V., Gallina S., Grasso R., Hanzel J., Taieb J. M., Lai M. A., Latella G., Lisi D., Lodi L., Marangi S., Mardegan A., Marlicz W., Maurano A., Milazzo G., Militaru V., Miraglia S., Monica F., Moskalev A., Natale A., Nicolas C., Pancetti A., Penna A., Pepe A. S., Pisano M., Pontone S., Prati M., Prisco A., Rando L., Hernandez E. R., Rosati O., Rossi G., Passoni G. R., Papa V., Nesme N. S., Schiffino L., Schillaci D., Selvaggi G., Taborchi F., Tornar A., Trebuna F., Triggiani C., Testai F. V., Vassallo R., Violi A., Tursi, A., Brandimarte, G., Di Mario, F., Lanas, A., Scarpignato, C., Bafutto, M., Barbara, G., Bassotti, G., Binda, G. A., Biondi, A., Biondo, S., Cassieri, C., Crucitti, A., Dumitrascu, D. L., Elisei, W., Escalante, R., Herszenyi, L., Kruis, W., Kupcinskas, J., Lahat, A., Lecca, P. G., Maconi, G., Malfertheiner, P., Mazzarri, A., Mearin, F., Milosavljevic, T., Nardone, G., de Oliveira, E. C., Papa, A., Papagrigoriadis, S., Pera, M., Persiani, R., Picchio, M., Regula, J., Stimac, D., Stollman, N., Strate, L. L., Walker, M. M. D., Allegretta, L., Altavilla, N., Amaro, P., Annunziata, M. L., Barberio, F., Basile, G., Bedogni, G., Belfiori, V., Benvenuti, S., Bertolami, C., Bisello, M., El Dammak, M. B., Bozzi, R., Buono, M., Cambie, G., Capezzuto, E., Casamassima, C., Chavoushian, A., Ciofani, R., Citarella, C., Compare, D., Cotruta, B., D'Amico, F., Dulk, M. D., Dyrda, B. E., Festa, V., Gallina, S., Grasso, R., Hanzel, J., Taieb, J. M., Lai, M. A., Latella, G., Lisi, D., Lodi, L., Marangi, S., Mardegan, A., Marlicz, W., Maurano, A., Milazzo, G., Militaru, V., Miraglia, S., Monica, F., Moskalev, A., Natale, A., Nicolas, C., Pancetti, A., Penna, A., Pepe, A. S., Pisano, M., Pontone, S., Prati, M., Prisco, A., Rando, L., Hernandez, E. R., Rosati, O., Rossi, G., Passoni, G. R., Papa, V., Nesme, N. S., Schiffino, L., Schillaci, D., Selvaggi, G., Taborchi, F., Tornar, A., Trebuna, F., Triggiani, C., Testai, F. V., Vassallo, R., Violi, A., Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G.A., Biondi A., Biondo S., Cassieri C., Crucitti A., Dumitrascu D.L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P.G., Maconi G., Malfertheiner P., Mazzari A., Mearin F., Milosavljevic T., Nardone G., Chavez De Oliveira E., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L.L., and Walker M.M.

Subjects
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Diverticular Disease, Endoscopic classification, Video Recording, Colonoscopy, Gastroenterology, Severity of Illness Index, endoscopic classification, Diverticulum, classification, complications, Diverticular diseases, Endoscopy, methods, Colonic Diseases, 0302 clinical medicine, Community Health Services, Community Health Service, Observer Variation, 0303 health sciences, medicine.diagnostic_test, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, agreement − colonoscopy − community setting − diverticular disease of the colon− endoscopic classification, 3. Good health, Diverticulosis, Malalties del còlon, Diverticular disease of the colon, Diverticular disease, 616.344-007.64 [udc], Community setting, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, Scoring system, Colonic Disease, Settore MED/12 - GASTROENTEROLOGIA, Reproducibility of Result, agreement, colonoscopy, community setting, diverticular disease of the colon, Agreement, 03 medical and health sciences, Internal medicine, Severity of illness, medicine, Diverticulosis, Colonic, Humans, Colonic diseases, 030304 developmental biology, Diverticular Diseases, business.industry, Colonoscòpia, Reproducibility of Results, medicine.disease, Inter-rater reliability, business, Kappa
Abstract

Background and Aims: The Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification of diverticulosis and diverticular disease (DD) is currently available. It scores severity of the disease as DICA 1, DICA 2 and DICA 3. Our aim was to assess the agreement on this classification in an international endoscopists community setting. Methods: A total of 96 doctors (82.9% endoscopists) independently scored a set of DD endoscopic videos. The percentages of overall agreement on DICA score and a free-marginal multirater kappa (κ) coefficient were reported as statistical measures of interrater agreement. Results: Overall agreement in using DICA was 91.8% with a free-marginal kappa of 88% (95% CI 80-95). The overall agreement levels were: DICA 1, 85.2%; DICA 2, 96.5%; DICA 3, 99.5%. The free marginal κ was: DICA 1 = 0.753, DICA 2 = 0.958, DICA 3 = 0.919. The agreement about the main endoscopic items was 83.4% (k 67%) for diverticular extension, 62.6% (k 65%) for number of diverticula for each district, 86.8% (k 82%) for presence of inflammation, and 98.5 (k 98%) for presence of complications. Conclusions: The overall interrater agreement in this study ranges from good to very good. DICA score is a simple and reproducible endoscopic scoring system for diverticulosis and DD.

Published
2019

8. International consensus on diverticulosis and diverticular disease. Statements from the 3rd international symposium on diverticular disease

Author

Tursi, A., Brandimarte, G., Di Mario, F., Lanas, A., Scarpignato, C., Bafutto, M., Barbara, G., Bassotti, G., Binda, G. A., Biondi, Alberto, Biondo, S., Cambie, G., Cassieri, C., Crucitti, Antonio, Dumitrascu, D. L., Elisei, W., Escalante, R., Herszenyi, L., Kruis, W., Kupcinskas, J., Lahat, A., Lecca, P. G., Maconi, G., Malfertheiner, P., Mazzari, A., Mearin, F., Milosavljevic, T., Nardone, G., de Oliveira, E. C., Papa, Alfredo, Papagrigoriadis, S., Pera, M., Persiani, Roberto, Picchio, M., Regula, J., Stimac, D., Stollman, N., Strate, L. L., Violi, A., Walker, M. M. D., Biondi A. (ORCID:0000-0002-2470-7858), Crucitti A. (ORCID:0000-0003-3496-4185), Persiani R. (ORCID:0000-0002-1537-5097), Tursi, A., Brandimarte, G., Di Mario, F., Lanas, A., Scarpignato, C., Bafutto, M., Barbara, G., Bassotti, G., Binda, G. A., Biondi, Alberto, Biondo, S., Cambie, G., Cassieri, C., Crucitti, Antonio, Dumitrascu, D. L., Elisei, W., Escalante, R., Herszenyi, L., Kruis, W., Kupcinskas, J., Lahat, A., Lecca, P. G., Maconi, G., Malfertheiner, P., Mazzari, A., Mearin, F., Milosavljevic, T., Nardone, G., de Oliveira, E. C., Papa, Alfredo, Papagrigoriadis, S., Pera, M., Persiani, Roberto, Picchio, M., Regula, J., Stimac, D., Stollman, N., Strate, L. L., Violi, A., Walker, M. M. D., Biondi A. (ORCID:0000-0002-2470-7858), Crucitti A. (ORCID:0000-0003-3496-4185), and Persiani R. (ORCID:0000-0002-1537-5097)

Abstract

The statements produced by the Chairmen and Speakers of the 3rd International Symposium on Diverticular Disease, held in Madrid on April 11th-13th 2019, are reported. Topics such as current and evolving concepts on the pathogenesis, the course of the disease, the news in diagnosing, hot topics in medical and surgical treatments, and finally, critical issues on the disease were reviewed by the Chairmen who proposed 39 statements graded according to level of evidence and strength of recommendation. Each topic was explored focusing on the more relevant clinical questions. The vote was conducted on a 6-point scale and consensus was defined a priori as 67% agreement of the participants. The voting group consisted of 124 physicians from 18 countries, and agreement with all statements was provided. Comments were added explaining some controversial areas.

Published
2019

15. Predictive value of the 'DICA' classification on the outcome of diverticular disease of the colon

Author

Tursi, A., Brandimarte, G., Di Mario, F., Andreoli, A., Annunziata, M. L., Astegiano, M., Bianco, M. A., Buri, L., Cammarota, G., Capezzuto, E., Chilovi, F., Cianci, M., Conigliaro, R., Del Favero, G., Elisei, W., Faggiani, R., Farroni, F., Forti, G., Germanà, B., Giorgetti, G., Giovannone, M., Lecca, P. G., Marmo, R., Occhigrossi, G., Penna, A., Rossi, A. F., Spadaccini, A., Zampaletta, C., Zilli, M., Zullo, A., Altavilla, N., Carlomagno, P., Colucci, R., De Bastiani, R., Di Cesare, L., Di Fonzo, M., Efrati, C., Ferrini, L., Fortuna, M., Graziani, M. G., Latella, Giovanni, Loperfido, S., Goni, E., Manes, G., Morucci, P., Papa, A., Pigò, F., Pranzo, G., Rotondano, G., Usai, P., Picchio, M., and Scarpignato, C. .

Published
2015

16. Predictive value of the ‘‘DICA’’ endoscopic classification on the outcome of the diverticular disease of the colon: an International study

Author

Tursi, A., Brandimarte, G., Di Mario, F., Annunziata, M. L., Bafutto, M., Bianco, M. A., Colucci, R., Conigliaro, R., Danese, S, De Bastiani, R., Elisei, W., Escalante, R., Faggiani, R., Ferrini, L., Forti, G., Latella, Giovanni, Graziani, M. G., Oliveira, E., Papa, A., Penna, A., Portincasa, P., Søreide, K., Spadaccini, A., Usai, P., Zampaletta, C., Cassieri, C., Desserud, K. F., Di Cesare, L., Fiorella, S., Landi, R., Lecca, P. G., Goni, E., Lai, M. A., Pigò, F., Rotondano, G., Schiaccianoce, G., Scarpignato, C., and Picchio, M.

Published
2015

17. Obscure occult gastrointestinal bleeding

Author

Riccioni, Maria Elena, Spada, Cristiano, Lecca, P. G., Costamagna, Guido, Riccioni M. E. (ORCID:0000-0002-9239-4312), Spada C. (ORCID:0000-0002-5692-0960), Costamagna G. (ORCID:0000-0002-8100-2731), Riccioni, Maria Elena, Spada, Cristiano, Lecca, P. G., Costamagna, Guido, Riccioni M. E. (ORCID:0000-0002-9239-4312), Spada C. (ORCID:0000-0002-5692-0960), and Costamagna G. (ORCID:0000-0002-8100-2731)

Abstract

n/a

Published
2005

18. High-dose Versus Low-dose Clarithromycin in 1-week Triple Therapy, Including Rabeprazole and Levofloxacin, for Helicobacter pylori Eradication

Author

Cammarota, Giovanni, Cianci, Rossella, Cannizzaro, O., Martino, A., Fedeli, P., Lecca, P. G., Di Caro, S., Cesaro, Paola, Branca, G., Gasbarrini, Giovanni Battista, Cammarota G. (ORCID:0000-0002-3626-6148), Cianci R. (ORCID:0000-0001-5378-8442), Cesaro P., Gasbarrini G., Cammarota, Giovanni, Cianci, Rossella, Cannizzaro, O., Martino, A., Fedeli, P., Lecca, P. G., Di Caro, S., Cesaro, Paola, Branca, G., Gasbarrini, Giovanni Battista, Cammarota G. (ORCID:0000-0002-3626-6148), Cianci R. (ORCID:0000-0001-5378-8442), Cesaro P., and Gasbarrini G.

Abstract

Goals: To compare high-dose versus low-dose clarithromycin in 1-week triple therapy including rabeprazole and levofloxacin. Background: Regimens containing rabeprazole and levofloxacin have proved to be effective against H. pylori infection. Study: One-hundred H. pylori-positive patients were randomly assigned to one of the following 1-week regimens: rabeprazole 20 mg o.d. plus levofloxacin 500 mg o.d. and clarithromycin 250 mg b.d. (RLC-1 group); rabeprazole 20 mg o.d. plus levofloxacin 500 mg o.d. and clarithromycin 500 mg b.d. (RLC-2 group). H. pylori status was assessed at entry and after the treatment. Patients who experienced treatment failure underwent antibiotic susceptibility testing. Results: Forty-two patients in RLC-1 group (both PP and ITT analysis: 84%; 95%CI: 71-93%) and 47 in RLC2 group (both PP and ITT analysis: 94%; 95% CI: 83-98%) became H. pylori negative. Clarithromycin resistance was detected in all of 8 (100%) RLC-1 failures and in 1 out of 3 (33%) RLC-2 failures. Side effects occurred in 8% of patients in RLC-1 group and in 12% in RLC-2. Conclusions: Regimens tested are competitive with other PPI-based treatments. One-week triple therapy containing rabeprazole plus, levofloxacin, and high-dose clarithromycin yielded a higher eradicating rate than the one containing low-dose clarithromycin and may be considered as a first-line therapy option.

Published
2004

19. Predictive value of the Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification on the outcome of diverticular disease of the colon: An international study

Author

Tursi, Antonio, Brandimarte, Giovanni, Di Mario, Francesco, Annunziata, Maria L, Bafutto, Mauro, Bianco, Maria A, Colucci, Raffaele, Conigliaro, Rita, Danese, Silvio, De Bastiani, Rudi, Elisei, Walter, Escalante, Ricardo, Faggiani, Roberto, Ferrini, Luciano, Forti, Giacomo, Latella, Giovanni, Graziani, Maria G, Oliveira, Enio C, Papa, Alfredo, Penna, Antonio, Portincasa, Piero, Søreide, Kjetil, Spadaccini, Antonio, Usai, Paolo, Bonovas, Stefanos, Scarpignato, Carmelo, Picchio, Marcello, Lecca, Piera G, Zampaletta, Costantino, Cassieri, Claudio, Damiani, Alberto, Desserud, Kari F, Fiorella, Serafina, Landi, Rosario, Goni, Elisabetta, Lai, Maria A, Pigò, Flavia, Rotondano, Gianluca, and Schiaccianoce, Giuseppe

Abstract

Background Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification has been recently developed for patients suffering from diverticulosis and diverticular disease.Aims We assessed retrospectively the predictive value of DICA in patients for whom endoscopic data and clinical follow-up were available.Methods For each patient, we recorded: age, severity of DICA, presence of abdominal pain, C-reactive protein and faecal calprotectin test (if available) at the time of diagnosis; months of follow-up; therapy taken during the follow-up to maintain remission (if any); occurrence/recurrence of diverticulitis; need of surgery.Results We enrolled 1651 patients (793 M, 858 F, mean age 66.6 ± 11.1 years): 939 (56.9%) patients were classified as DICA 1, 501 (30.3%) patients as DICA 2 and 211 (12.8%) patients as DICA 3. The median follow-up was 24 (9–38) months. Acute diverticulitis (AD) occurred/recurred in 263 (15.9%) patients; surgery was necessary in 57 (21.7%) cases. DICA was the only factor significantly associated to the occurrence/recurrence of diverticulitis and surgery either at univariate (χ2 = 405.029; p< 0.0001) or multivariate analysis (hazard ratio = 4.319, 95% confidence interval (CI) 3.639–5.126; p< 0.0001). Only in DICA 2 patients was therapy effective for prevention of AD occurrence/recurrence with a hazard ratio (95% CI) of 0.598 (0.391–0.914) (p= 0.006, log rank test). Mesalazine-based therapies reduced the risk of AD occurrence/recurrence and needs of surgery with a hazard ratio (95% CI) of 0.2103 (0.122–0.364) and 0.459 (0.258–0.818), respectively.Conclusions DICA classification is a valid parameter to predict the risk of diverticulitis occurrence/recurrence in patients suffering from diverticular disease of the colon.

Published
2016
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20. Effectiveness of different therapeutic strategies in preventing diverticulitis recurrence.

Author

TURSI, A., ELISEI, W., GIORGETTI, G. M., INCHINGOLO, C. D., NENNA, R., PICCHIO, M., MAIORANO, M., PENNA, A., LECCA, P. G., and BRANDIMARTE, G.

Abstract

BACKGROUND: Colonic diverticulitis shows a high recurrence rate. AIMS: To assess the efficacy of three different therapeutic strategies in preventing diverticulitis recurrence. MATERIALS AND METHODS: One hundred thirty patients suffering from Acute Uncomplicated Diverticulitis (AUD) (81 males, 49 females, mean age 64.71 years, range 40-85) were prospectively assessed. After obtaining remission, considered present when both endoscopic and histological damage were absent, the patients were treated with mesalazine 1.6 g/day (59 patients, group A), or rifaximin 800 mg/day for 7 days every month (52 patients, group B). Clinical, endoscopic and histological follow-up was performed after 6, 12 and thereafter every 12 months after diagnosis of AUD. RESULTS: Seven patients were excluded from final evaluation because they were lost to follow-up. Fifty-five group A patients and 49 group B patients patients were available for the final assessment at the end of a 24-month follow-up. Sustained remission was significantly higher in group A with respect to group B. CONCLUSIONS: Patients taking mesalazine have lower risk of diverticulitis recurrence than patients taking rifaximin because of the lower prevalence of persisting endoscopic and histological inflammation. [ABSTRACT FROM AUTHOR]

Published
2013

21. Prevalence of celiac disease and symptoms in relatives of patients with celiac disease.

Author

TURSI, A., ELISEI, W., GIORGETTI, G. M., GASPARDONE, A., LECCA, P. G., DI CESARE, L., and BRANDIMARTE, G.

Abstract

Background and Objectives: We determined the prevalence and clinical features of celiac disease (CD) in family-members (FMs) of a population-based cohort of index cases. Materials and Methods: We recruited 108 CD index cases: mean age at diagnosis, 23.0 years (range, 1.5-45.2 years); 81 (75%) female. Three-hundred twelve (mean age, 41.6 years; 219 [70%] female) of FMs were analyzed. 153 (49%) were parents, 24 (7.7%) were children, 69 (22.2%) were siblings, 66 (21.1%) were second degree FMs. Results: CD was diagnosed in 63 subjects (20.1%, 21 males and 42 females, mean age 34.24 years, range 2-81 years). Classic, subclinical, and silent forms of CD were recognized in 18 [28.6% (6 siblings, 6 parents, 3 child, 3 second-degree FMs], in 27 [45.8% (9 siblings, 3 parent, 15 second-degree FMs], and in 18 [28.6% (6 siblings, 6 parents, 6 second-degree FMs) cases, respectively. Most of patients suffering from "classical" (18/63 patients, 28.7%) and "subclinical" (27/63 patients, 42.9%) form of CD were older than patients suffering from "silent " CD (18/63 patients, 28.7%) (p=0.01). Most of patients suffering from subclinical disease showed autoimmune diseases (Hashimoto's thyroiditis, and psoriasis), and other atypical symptoms, as gastroesophageal reflux disease (GERD), were also recorded. Conclusions: We found an high-prevalence of CD between CD FMs, and most of them were oly-goor asymptomatic. [ABSTRACT FROM AUTHOR]

Published
2010

24. International consensus on diverticulosis and diverticular disease. Statements from the 3rd international symposium on diverticular disease

Author

Marjorie M. Walker, László Herszényi, Giovanni Barbara, Gabrio Bassotti, Wolfgang Kruis, Angel Lanas, G. Cambiè, Enio Chavez De Oliveira, Andrea Mazzari, A. Violi, Jaroslaw Regula, Giovanni Brandimarte, Roberto Persiani, Walter Elisei, Miguel Pera, Marcello Picchio, Sebastiano Biondo, Fermín Mearin, Claudio Cassieri, Juozas Kupcinskas, Savvas Papagrigoriadis, Antonio Tursi, Giovanni Maconi, Davor Štimac, Antonio Crucitti, Ricardo Escalante, Neil Stollman, Lisa L. Strate, P.G. Lecca, M. Bafutto, Gerardo Nardone, Tomica Milosavljeviċ, Carmelo Scarpignato, Alfredo Papa, Francesco Di Mario, Alberto Biondi, Gian Andrea Binda, Dan L. Dumitrascu, Adi Lahat, Peter Malfertheiner, Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G.A., Biondi A., Biondo S., Cambie G., Cassieri C., Crucitti A., Dumitrascu D.L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P.G., Maconi G., Malfertheiner P., Mazzari A., Mearin F., Milosavljevic T., Nardone G., de Oliveira E.C., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L.L., Violi A., Walker M.M.D., Tursi, A., Brandimarte, G., Di Mario, F., Lanas, A., Scarpignato, C., Bafutto, M., Barbara, G., Bassotti, G., Binda, G. A., Biondi, A., Biondo, S., Cambie, G., Cassieri, C., Crucitti, A., Dumitrascu, D. L., Elisei, W., Escalante, R., Herszenyi, L., Kruis, W., Kupcinskas, J., Lahat, A., Lecca, P. G., Maconi, G., Malfertheiner, P., Mazzari, A., Mearin, F., Milosavljevic, T., Nardone, G., de Oliveira, E. C., Papa, A., Papagrigoriadis, S., Pera, M., Persiani, R., Picchio, M., Regula, J., Stimac, D., Stollman, N., Strate, L. L., Violi, A., and Walker, M. M. D.

Subjects
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Medical therapy, Etiology, Disease, 0302 clinical medicine, Voting, Diagnosis, Medicine, Disease management (health), Diverticuliti, health care economics and organizations, media_common, Diverticulosis, Evidence-Based Medicine, Diverticulosi, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Gastroenterology, Consensus, Diverticular disease, Diverticulitis, Surgical therapy, 3. Good health, Malalties inflamatòries intestinals, Hot topics, 030220 oncology & carcinogenesis, Etiologia, 030211 gastroenterology & hepatology, Diagnosi, medicine.medical_specialty, Settore MED/12 - GASTROENTEROLOGIA, media_common.quotation_subject, education, MEDLINE, Consensu, Therapeutics, Inflammatory bowel diseases, diverticulosis – diverticular disease – diverticulitis – consensus – diagnosis – medical therapy – surgical therapy, 03 medical and health sciences, Humans, Diverticular Diseases, business.industry, Evidence-based medicine, Congresses as Topic, medicine.disease, Terapèutica, Diverticulum, Family medicine, business
Abstract

The statements produced by the Chairmen and Speakers of the 3rd International Symposium on Diverticular Disease, held in Madrid on April 11th-13th 2019, are reported. Topics such as current and evolving concepts on the pathogenesis, the course of the disease, the news in diagnosing, hot topics in medical and surgical treatments, and finally, critical issues on the disease were reviewed by the Chairmen who proposed 39 statements graded according to level of evidence and strength of recommendation. Each topic was explored focusing on the more relevant clinical questions. The vote was conducted on a 6-point scale and consensus was defined a priori as 67% agreement of the participants. The voting group consisted of 124 physicians from 18 countries, and agreement with all statements was provided. Comments were added explaining some controversial areas.

Published
2019

25. Concomitant intraductal papillary mucinous neoplasm and pancreatic endocrine tumour: Report of two cases and review of the literature.

Author

Larghi A, Stobinski M, Galasso D, Lecca PG, and Costamagna G

Subjects
Carcinoma, Pancreatic Ductal diagnosis, Endosonography methods, Female, Gastrointestinal Agents, Humans, Middle Aged, Pancreas pathology, Secretin, Adenocarcinoma, Mucinous diagnosis, Carcinoma, Neuroendocrine diagnosis, Carcinoma, Papillary diagnosis, Cholangiopancreatography, Magnetic Resonance methods, Pancreatic Neoplasms diagnosis
Abstract

It has been suggested that the occurrence of intraductal papillary mucinous neoplasms in association with pancreatic endocrine tumours is more frequent than expected [Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, et al. Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology 2006;6:520-6]. Up to now, 10 patients with concomitant intraductal papillary mucinous neoplasms and pancreatic endocrine tumours have been reported [Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, et al. Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology 2006;6:520-6; Zhao X, Stabile BE, Mo J, Wang J, French SW. Nesidioblastosis coexisting with islet cell tumor and intraductal papillary mucinous hyperplasia. Arch Pathol Lab Med 2001;125:1344-7; Marrache F, Cazals-Hatem D, Kianmanesh R, Palazzo L, Couvelard A, O'Toole D, et al. Endocrine tumor and intraductal papillary mucinous neoplasm of the pancreas: a fortuitous association? Pancreas 2005;31:79-83]. In most cases the synchronous existence of both tumours was incidentally discovered after the examination of the surgical specimen. We report two additional patients with intraductal papillary mucinous neoplasms and pancreatic endocrine tumours, in whom both tumours were diagnosed before surgery.

Published
2009
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