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367 results on '"Lecommandoux S"'

1. Quantitative Side-Chain Modifications of Methionine-Containing Elastin-Like Polypeptides as a Versatile Tool to Tune Their Properties

Author

Kramer, JR, Petitdemange, R, Bataille, L, Bathany, K, Wirotius, AL, Garbay, B, Deming, TJ, Garanger, E, and Lecommandoux, S

Subjects
Macromolecular and Materials Chemistry, Resources Engineering and Extractive Metallurgy, Physical Chemistry, Physical Chemistry (incl. Structural)
Abstract

Tuning the lower critical solution temperature (LCST) of temperature-responsive recombinant elastin-like polypeptides has usually been achieved by designing different protein sequences, in terms of amino acid composition and length, implying tedious molecular cloning steps. In the present work, we have explored the chemoselective alkylation of methionine as an easy means to modify elastin repeat side chains and easily modulate the LCST of the polypeptides. Such a versatile synthetic method shall practically be exploited to modulate any properties of recombinant polymers.

Published
2015

6. Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones

Author

Salas-Ambrosio, P., Tronnet, A., Since, M., Bourgeade-Delmas, Sandra, Stigliani, J. L., Vax, A., Lecommandoux, S., Dupuy, B., Verhaeghe, P., and Bonduelle, C.

Abstract

Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(alpha-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections.

Published
2021

14. ADMET polymerization of $��$,$��$-unsaturated glycolipids: synthesis and physico-chemical properties of the resulting polymers

Author

Hibert, Geoffrey, Grau, Etienne, Pintori, Didier, Lecommandoux, S��bastien, and Cramail, Henri

Subjects
Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Applied Physics (physics.app-ph)
Abstract

Trehalose diesters exhibiting $��$,$��$-unsaturation are glycolipids which can be easily polymerized by ADMET (acyclic diene metathesis) polymerization. In this paper, enzymatic esterification was performed to selectively esterify primary hydroxyl groups of trehalose (6 and 6'-positions) with vinyl undecenoate. The vinyl ester was beforehand obtained by palladium-catalyzed transesterification of undecenoic acid with vinyl acetate. The resulting trehalose diundecenoate was homopolymerized and copolymerized with undecenyl undecenoate in order to obtain random copolymers with different compositions. The synthesis of such copolymers was confirmed by 1 H NMR spectroscopy and size exclusion chromatography (SEC). Their solid-state phase separation were investigated by DSC and X-ray scattering as function of temperature and their solution self-assembly was investigated by dynamic light scattering (DLS) in water.

Published
2019
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17. Boundary lubricant films under shear: Effect of roughness and adhesion.

Author

Drummond, C., Rodríguez-Hernández, J., Lecommandoux, S., and Richetti, P.

Subjects
SURFACE roughness, ADHESION, MICA, COPOLYMERS, SHEAR flow
Abstract

The normal interaction and the behavior under shear of mica surfaces covered by two different triblock copolymers of polylysine-polydimethysiloxane-polylysine were studied by combining the capabilities of the surface forces apparatus and the atomic force microscopy. At low pH values these copolymers spontaneously adsorb on the negatively charged mica surfaces from aqueous solutions as a consequence of the positive charge of the polylysine moieties. The morphology of the adsorbed layer is determined by the molecular structure of the particular copolymer investigated. This morphology plays a fundamental role on the behavior of the adsorbed layers under shear and compression. While nonadhesive smooth layers oppose an extremely small resistance to sliding, the presence of asperities even at the nanometric scale originates a frictional resistance to the motion. The behavior of uniform nonadhesive nanorough surfaces under shear can be quantitatively understood in terms of a simple multistable thermally activated junction model. The electric charge of the adsorbed copolymer molecules and hence the adhesion energy between the coated surfaces can be modified by varying the pH of the surrounding media. In the presence of an adhesive interaction between the surfaces the behavior under shear is strongly modified. Time-dependent mechanisms of energy dissipation have to be evoked in order to explain the changes observed. [ABSTRACT FROM AUTHOR]

Published
2007
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24. Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers

Author

Voisin P, Lecommandoux S, Bouchaud, Le Meins Jf, Ibarboure E, Ambikanandan Misra, Kamal Kumar Upadhyay, Schatz C, Pharm Dept, Fac Technol & Eng, Univ Baroda, University of Baroda, India, Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Team 3 LCPO : Polymer Self-Assembly & Life Sciences, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Centre de résonance magnétique des systèmes biologiques (CRMSB), and Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)

Subjects
polypeptide, Polymers and Plastics, Polymers, Bioengineering, Antineoplastic Agents, block copolymer, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, chemistry.chemical_compound, Cell Line, Tumor, Hyaluronic acid, Materials Chemistry, Copolymer, Humans, Hyaluronic Acid, targeting, vesicle, Polyglutamate, Brain Neoplasms, Vesicle, Molecular Mimicry, Glioma, biomimetic, 021001 nanoscience & nanotechnology, 0104 chemical sciences, [CHIM.POLY]Chemical Sciences/Polymers, Biochemistry, chemistry, Polyglutamic Acid, Doxorubicin, polysaccharide, Drug delivery, Polymersome, Biophysics, Click chemistry, 0210 nano-technology, Drug carrier
Abstract

International audience; Using "click chemistry" as an easy and versatile synthetic strategy to combine hyaluronan and polyglutamate blocks, we have prepared nanovesicles (polymersomes) that present a controlled size, excellent colloidal stability, and a high loading capacity for hydrophilic and hydrophobic drugs. The unique feature of our concept is the use of hyaluronan, a polysaccharide with known capacity for targeting cancer-related protein receptors, as the hydrophilic portion of a block copolymer system. The cytotoxicity and internalization mechanism of doxorubicin-loaded polymersomes have been evaluated in C6 glioma tumor cell lines. The dual purpose served by hyaluronan, as both a hydrophilic block critical to vesicle formation and as a binding agent for biological targets, breaks new ground in terms of multifunctional nanomaterial design for drug delivery.

Published
2009

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