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3. Graft-Versus-Host Disease Induces Immune Dysregulation through Irreversible Damage to Specialized Immune-Interacting Fibroblastic Stromal Cells in Secondary Lymphoid Organs

Author

Carrington, Leolene, primary, Bandyopadhyay, Shovik, additional, Lederer, Katlyn, additional, Kelly, Samantha, additional, Vanderbeck, Ashley, additional, Jih, Gloria, additional, Allen, Frederick, additional, Gómez Atria, Daniela, additional, Allman, Anneka, additional, Perkey, Eric, additional, Tan, Kai, additional, Pardi, Norbert, additional, Ludewig, Burkhard, additional, Chakraverty, Ronjon, additional, and Maillard, Ivan, additional

Published
2022
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4. Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Author

Alameh, Mohamad-Gabriel, primary, Tombácz, István, additional, Bettini, Emily, additional, Lederer, Katlyn, additional, Sittplangkoon, Chutamath, additional, Wilmore, Joel R., additional, Gaudette, Brian T., additional, Soliman, Ousamah Y., additional, Pine, Matthew, additional, Hicks, Philip, additional, Manzoni, Tomaz B., additional, Knox, James J., additional, Johnson, John L., additional, Laczkó, Dorottya, additional, Muramatsu, Hiromi, additional, Davis, Benjamin, additional, Meng, Wenzhao, additional, Rosenfeld, Aaron M., additional, Strohmeier, Shirin, additional, Lin, Paulo J.C., additional, Mui, Barbara L., additional, Tam, Ying K., additional, Karikó, Katalin, additional, Jacquet, Alain, additional, Krammer, Florian, additional, Bates, Paul, additional, Cancro, Michael P., additional, Weissman, Drew, additional, Luning Prak, Eline T., additional, Allman, David, additional, Locci, Michela, additional, and Pardi, Norbert, additional

Published
2022
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5. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

Author

Lederer, Katlyn, primary, Bettini, Emily, additional, Parvathaneni, Kalpana, additional, Painter, Mark M., additional, Agarwal, Divyansh, additional, Lundgreen, Kendall A., additional, Weirick, Madison, additional, Muralidharan, Kavitha, additional, Castaño, Diana, additional, Goel, Rishi R., additional, Xu, Xiaoming, additional, Drapeau, Elizabeth M., additional, Gouma, Sigrid, additional, Ort, Jordan T., additional, Awofolaju, Moses, additional, Greenplate, Allison R., additional, Le Coz, Carole, additional, Romberg, Neil, additional, Trofe-Clark, Jennifer, additional, Malat, Gregory, additional, Jones, Lisa, additional, Rosen, Mark, additional, Weiskopf, Daniela, additional, Sette, Alessandro, additional, Besharatian, Behdad, additional, Kaminiski, Mary, additional, Hensley, Scott E., additional, Bates, Paul, additional, Wherry, E. John, additional, Naji, Ali, additional, Bhoj, Vijay, additional, and Locci, Michela, additional

Published
2022
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6. Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Author

Alameh, Mohamad-Gabriel, primary, Tombácz, István, additional, Bettini, Emily, additional, Lederer, Katlyn, additional, Ndeupen, Sonia, additional, Sittplangkoon, Chutamath, additional, Wilmore, Joel R., additional, Gaudette, Brian T., additional, Soliman, Ousamah Y., additional, Pine, Matthew, additional, Hicks, Philip, additional, Manzoni, Tomaz B., additional, Knox, James J., additional, Johnson, John L., additional, Laczkó, Dorottya, additional, Muramatsu, Hiromi, additional, Davis, Benjamin, additional, Meng, Wenzhao, additional, Rosenfeld, Aaron M., additional, Strohmeier, Shirin, additional, Lin, Paulo J.C., additional, Mui, Barbara L., additional, Tam, Ying K., additional, Karikó, Katalin, additional, Jacquet, Alain, additional, Krammer, Florian, additional, Bates, Paul, additional, Cancro, Michael P., additional, Weissman, Drew, additional, Luning Prak, Eline T., additional, Allman, David, additional, Igyártó, Botond Z., additional, Locci, Michela, additional, and Pardi, Norbert, additional

Published
2021
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7. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

Author

Lederer, Katlyn, primary, Parvathaneni, Kalpana, additional, Painter, Mark M., additional, Bettini, Emily, additional, Agarwal, Divyansh, additional, Lundgreen, Kendall A., additional, Weirick, Madison, additional, Goel, Rishi R., additional, Xu, Xiaoming, additional, Drapeau, Elizabeth M., additional, Gouma, Sigrid, additional, Greenplate, Allison R., additional, Coz, Carole Le, additional, Romberg, Neil, additional, Jones, Lisa, additional, Rosen, Mark, additional, Besharatian, Behdad, additional, Kaminiski, Mary, additional, Weiskopf, Daniela, additional, Sette, Alessandro, additional, Hensley, Scott E., additional, Bates, Paul, additional, Wherry, E. John, additional, Naji, Ali, additional, Bhoj, Vijay, additional, and Locci, Michela, additional

Published
2021
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8. Stroma-Driven Notch2 Signaling Controls Naïve B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Author

Allman, Anneka, Gaudette, Brian, Kelly, Samantha, Alouche, Nagham, Carrington, Leolene, Perkey, Eric, Outen, Riley, Vanderbeck, Ashley, Lederer, Katlyn, Robertson, Tanner F., Burkhardt, Janis K., Tikhonova, Anastasia N., Aifantis, Iannis, Koch, Ute, Radtke, Freddy, Ludewig, Burkhard, Tveriakhina, Lena, Gossler, Achim, Siebel, Christian W., Gomez Atria, Daniela, Luther, Sanjiv, Allman, David, and Maillard, Ivan

Published
2023
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9. CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response

Author

Lu, Yisi, primary, Jiang, Roy, additional, Freyn, Alec W., additional, Wang, Jiawei, additional, Strohmeier, Shirin, additional, Lederer, Katlyn, additional, Locci, Michela, additional, Zhao, Hongyu, additional, Angeletti, Davide, additional, O’Connor, Kevin C., additional, Kleinstein, Steven H., additional, Nachbagauer, Raffael, additional, and Craft, Joe, additional

Published
2020
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10. SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

Author

Lederer, Katlyn, primary, Castaño, Diana, additional, Gómez Atria, Daniela, additional, Oguin, Thomas H., additional, Wang, Sidney, additional, Manzoni, Tomaz B., additional, Muramatsu, Hiromi, additional, Hogan, Michael J., additional, Amanat, Fatima, additional, Cherubin, Patrick, additional, Lundgreen, Kendall A., additional, Tam, Ying K., additional, Fan, Steven H.Y., additional, Eisenlohr, Laurence C., additional, Maillard, Ivan, additional, Weissman, Drew, additional, Bates, Paul, additional, Krammer, Florian, additional, Sempowski, Gregory D., additional, Pardi, Norbert, additional, and Locci, Michela, additional

Published
2020
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11. A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

Author

Laczkó, Dorottya, primary, Hogan, Michael J., additional, Toulmin, Sushila A., additional, Hicks, Philip, additional, Lederer, Katlyn, additional, Gaudette, Brian T., additional, Castaño, Diana, additional, Amanat, Fatima, additional, Muramatsu, Hiromi, additional, Oguin, Thomas H., additional, Ojha, Amrita, additional, Zhang, Lizhou, additional, Mu, Zekun, additional, Parks, Robert, additional, Manzoni, Tomaz B., additional, Roper, Brianne, additional, Strohmeier, Shirin, additional, Tombácz, István, additional, Arwood, Leslee, additional, Nachbagauer, Raffael, additional, Karikó, Katalin, additional, Greenhouse, Jack, additional, Pessaint, Laurent, additional, Porto, Maciel, additional, Putman-Taylor, Tammy, additional, Strasbaugh, Amanda, additional, Campbell, Tracey-Ann, additional, Lin, Paulo J.C., additional, Tam, Ying K., additional, Sempowski, Gregory D., additional, Farzan, Michael, additional, Choe, Hyeryun, additional, Saunders, Kevin O., additional, Haynes, Barton F., additional, Andersen, Hanne, additional, Eisenlohr, Laurence C., additional, Weissman, Drew, additional, Krammer, Florian, additional, Bates, Paul, additional, Allman, David, additional, Locci, Michela, additional, and Pardi, Norbert, additional

Published
2020
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12. CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response

Author

Lu, Yisi, Jiang, Roy, Freyn, Alec W., Wang, Jiawei, Strohmeier, Shirin, Lederer, Katlyn, Locci, Michela, Zhao, Hongyu, Angeletti, Davide, O’Connor, Kevin C., Kleinstein, Steven H., Nachbagauer, Raffael, and Craft, Joe

Abstract

CD4+ follicular regulatory T (Tfr) cells control B cell responses through the modulation of follicular helper T (Tfh) cells and germinal center development while suppressing autoreactivity; however, their role in the regulation of productive germinal center B cell responses and humoral memory is incompletely defined. We show that Tfr cells promote antigen-specific germinal center B cell responses upon influenza virus infection. Following viral challenge, we found that Tfr cells are necessary for robust generation of virus-specific, long-lived plasma cells, antibody production against both hemagglutinin (HA) and neuraminidase (NA), the two major influenza virus glycoproteins, and appropriate regulation of the BCR repertoire. To further investigate the functional relevance of Tfr cells during viral challenge, we used a sequential immunization model with repeated exposure of antigenically partially conserved strains of influenza viruses, revealing that Tfr cells promote recall antibody responses against the conserved HA stalk region. Thus, Tfr cells promote antigen-specific B cell responses and are essential for the development of long-term humoral memory.

Published
2021
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13. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals.

Author

Lederer K, Parvathaneni K, Painter MM, Bettini E, Agarwal D, Lundgreen KA, Weirick M, Goel RR, Xu X, Drapeau EM, Gouma S, Greenplate AR, Coz CL, Romberg N, Jones L, Rosen M, Besharatian B, Kaminiski M, Weiskopf D, Sette A, Hensley SE, Bates P, Wherry EJ, Naji A, Bhoj V, and Locci M

Abstract

Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals has not yet been performed due to the challenge of directly probing human lymph nodes. In this study, through a fine-needle-aspiration-based approach, we profiled the immune responses to SARS-CoV-2 mRNA vaccines in lymph nodes of healthy individuals and kidney transplant (KTX) recipients. We found that, unlike healthy subjects, KTX recipients presented deeply blunted SARS-CoV-2-specific GC B cell responses coupled with severely hindered T follicular helper cells, SARS-CoV-2 receptor-binding-domain-specific memory B cells and neutralizing antibodies. KTX recipients also displayed reduced SARS-CoV-2-specific CD4 and CD8 T cell frequencies. Broadly, these data indicate impaired GC-derived immunity in immunocompromised individuals, and suggest a GC-origin for certain humoral and memory B cell responses following mRNA vaccination.

Published
2021
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