27 results on '"Lederman RI"'
Search Results
2. Elements of external validity of tools for health: an intervention for construction laborers.
- Author
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Hunt MK, Harley AE, Stoddard AM, Lederman RI, Macarthur MJ, and Sorensen G
- Abstract
Abstract Purpose To examine the external validity of an efficacious tailored smoking cessation and nutrition improvement telephone intervention. Design Comparison of characteristics of participants and nonparticipants (representativeness); examination of the extent of intervention implementation. Setting Cancer center collaboration with a labor union. Subjects Unionized construction laborers. Intervention Tailored feedback report, telephone counseling, and supplementary educational materials focused on smoking cessation and improved nutrition. Measures Background survey identifying socio-demographic and behavioral characteristics; process evaluation data; and final efficacy survey to determine participant satisfaction. Analysis Cross-classification and the chi(2) test of homogeneity were used with categorically measured variables comparing participants and nonparticipants. We compared the means in the two groups for continuously scaled measures using the Student t-test and investigated the multivariable association of the characteristics of participation with a multiple logistic regression. For process data we present frequencies, percentages, and means. Results Characteristics associated with participation included self-efficacy to change fruit and vegetable consumption (p = .0009) and self-identification with union's problems (p = 0.05). Eighty-six percent of non-smokers and 61% of smokers completed between 1 and 4 counseling sessions. Over one-half of non-smokers (61%) and smokers (53%) completed 4 or more calls and more smokers (34%) than non-smokers (11%) completed the 5+ sessions. Conclusions These results provide a snapshot of characteristics of construction laborers to whom this intervention can be generalized and indicators of feasibility necessary for translating research into practice. [ABSTRACT FROM AUTHOR]
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- 2010
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3. Clonal hematopoiesis in older patients with breast cancer receiving chemotherapy.
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Mayerhofer C, Sedrak MS, Hopkins JO, Li T, Tayob N, Faggen MG, Sinclair NF, Chen WY, Parsons HA, Mayer EL, Lange PB, Basta AS, Perilla-Glen A, Lederman RI, Wong AR, Tiwari A, McAllister SS, Mittendorf EA, Gibson CJ, Burstein HJ, Kim AS, Freedman RA, and Miller PG
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- Humans, Female, Aged, Retrospective Studies, Hematopoiesis genetics, Mutation, Clonal Hematopoiesis genetics, Breast Neoplasms drug therapy, Breast Neoplasms genetics
- Abstract
Background: The expansion of hematopoietic stem cells carrying recurrent somatic mutations, termed clonal hematopoiesis (CH), is common in elderly individuals and is associated with increased risk of myeloid malignancy and all-cause mortality. Though chemotherapy is a known risk factor for developing CH, how myelosuppressive therapies affect the short-term dynamics of CH remains incompletely understood. Most studies have been limited by retrospective design, heterogeneous patient populations, varied techniques to identifying CH, and analysis of single timepoints., Methods: We examined serial samples from 40 older women with triple-negative or hormone receptor-positive breast cancer treated on the prospective ADjuVANt Chemotherapy in the Elderly trial to evaluate the prevalence and dynamics of CH at baseline and throughout chemotherapy (6 and 12 weeks)., Results: CH was detected in 44% of patients at baseline and in 53% at any timepoint. Baseline patient characteristics were not associated with CH. Over the course of treatment, mutations exhibited a variety of dynamics, including emergence, expansion, contraction, and disappearance. All mutations in TP53 (n = 3) and PPM1D (n = 4), genes that regulate the DNA damage response, either became detectable or expanded over the course of treatment. Neutropenia was more common in patients with CH, particularly when the mutations became detectable during treatment, and CH was significantly associated with cyclophosphamide dose reductions and holds (P = .02)., Conclusions: Our study shows that CH is common, dynamic, and of potential clinical significance in this population. Our results should stimulate larger efforts to understand the biological and clinical importance of CH in solid tumor malignancies., Trial Registration: ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT03858322). Clinical trial registration number: NCT03858322., (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2023
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4. Breast cancer treatment receipt and the role of financial stress, health literacy, and numeracy among diverse breast cancer survivors.
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Odai-Afotey A, Lederman RI, Ko NY, Gagnon H, Fikre T, Gundersen DA, Revette AC, Hershman DL, Crew KD, Keating NL, and Freedman RA
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- Adult, Humans, Female, Financial Stress, Survivors, Breast Neoplasms epidemiology, Breast Neoplasms therapy, Cancer Survivors, Health Literacy
- Abstract
Purpose: Disparities in breast cancer treatment for low-income and minority women are well documented. We examined economic hardship, health literacy, and numeracy and whether these factors were associated with differences in receipt of recommended treatment among breast cancer survivors., Methods: During 2018-2020, we surveyed adult women diagnosed with stage I-III breast cancer between 2013 and 2017 and received care at three centers in Boston and New York. We inquired about treatment receipt and treatment decision-making. We used Chi-squared and Fisher's exact tests to examine associations between financial strain, health literacy, numeracy (using validated measures), and treatment receipt by race and ethnicity., Results: The 296 participants studied were 60.1% Non-Hispanic (NH) White, 25.0% NH Black, and 14.9% Hispanic; NH Black and Hispanic women had lower health literacy and numeracy and reported more financial concerns. Overall, 21 (7.1%) women declined at least one component of recommended therapy, without differences by race and ethnicity. Those not initiating recommended treatment(s) reported more worry about paying large medical bills (52.4% vs. 27.1%), worse household finances since diagnosis (42.9% vs. 22.2%), and more uninsurance before diagnosis (9.5% vs. 1.5%); all P < .05. No differences in treatment receipt by health literacy or numeracy were observed., Conclusion: In this diverse population of breast cancer survivors, rates of treatment initiation were high. Worry about paying medical bills and financial strain were frequent, especially among non-White participants. Although we observed associations of financial strain with treatment initiation, because few women declined treatments, understanding the scope of impact is limited. Our results highlight the importance of assessments of resource needs and allocation of support for breast cancer survivors. Novelty of this work includes the granular measures of financial strain and inclusion of health literacy and numeracy., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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5. 'ADVANCE' (a pilot trial) ADjuVANt chemotherapy in the elderly: Developing and evaluating lower-toxicity chemotherapy options for older patients with breast cancer.
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Freedman RA, Li T, Sedrak MS, Hopkins JO, Tayob N, Faggen MG, Sinclair NF, Chen WY, Parsons HA, Mayer EL, Lange PB, Basta AS, Perilla-Glen A, Lederman RI, Wong A, Tiwari A, McAllister SS, Mittendorf EA, Miller PG, Gibson CJ, and Burstein HJ
- Subjects
- Humans, Female, Aged, Carboplatin, Pilot Projects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Paclitaxel, Chemotherapy, Adjuvant, Cyclophosphamide, Breast Neoplasms drug therapy
- Abstract
Introduction: Older adults with breast cancer receiving neo/adjuvant chemotherapy are at high risk for poor outcomes and are underrepresented in clinical trials. The ADVANCE (ADjuVANt Chemotherapy in the Elderly) trial evaluated the feasibility of two neo/adjuvant chemotherapy regimens in parallel-enrolling cohorts of older patients with human epidermal growth factor receptor 2-negative breast cancer: cohort 1-triple-negative; cohort 2-hormone receptor-positive., Materials and Methods: Adults age ≥ 70 years with stage I-III breast cancer warranting neo/adjuvant chemotherapy were enrolled. Cohort 1 received weekly carboplatin (area under the curve 2) and weekly paclitaxel 80 mg/m
2 for twelve weeks; cohort 2 received weekly paclitaxel 80 mg/m2 plus every-three-weekly cyclophosphamide 600 mg/m2 over twelve weeks. The primary study endpoint was feasibility, defined as ≥80% of patients receiving ≥80% of intended weeks/doses of therapy. All dose modifications were applied per clinician discretion., Results: Forty women (n = 20 per cohort) were enrolled from March 25, 2019 through August 3, 2020 from three centers; 45% and 35% of patients in cohorts 1 and 2 were age > 75, respectively. Neither cohort achieved targeted thresholds for feasibility. In cohort 1, eight (40.0%) met feasibility (95% confidence interval [CI] = 19.1-63.9%), while ten (50.0%) met feasibility in cohort 2 (95% CI = 27.2-72.8). Neutropenia was the most common grade 3-4 toxicity (cohort 1-65%, cohort 2-55%). In cohort 1, 80% and 85% required ≥1 dose holds of carboplatin and/or paclitaxel, respectively. In cohort 2, 10% required dose hold(s) for cyclophosphamide and/or 65% for paclitaxel., Discussion: In this pragmatic pilot examining chemotherapy regimens in older adults with breast cancer, neither regimen met target goals for feasibility. Developing efficacious and tolerable regimens for older patients with breast cancer who need chemotherapy remains an important goal., Clinicaltrials: gov Identifier: NCT03858322., (Copyright © 2022 Elsevier Ltd. All rights reserved.)- Published
- 2023
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6. Breast cancer knowledge and understanding treatment rationales among diverse breast cancer survivors.
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Freedman RA, Ko NY, Lederman RI, Gagnon H, Fikre T, Gundersen DA, Revette AC, Odai-Afotey A, Kantor O, Hershman DL, Crew KD, and Keating NL
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- Humans, Female, Survivors, Hispanic or Latino, Black People, Cancer Survivors, Breast Neoplasms therapy, Breast Neoplasms drug therapy
- Abstract
Purpose: The degree to which breast cancer survivors know about their tumors and understand treatment rationales is not well understood. We sought to identify information gaps within a diverse sample and explore whether knowledge about breast cancer and treatment may impact care., Methods: We conducted a one-time, interviewer-administered survey of women who were diagnosed with breast cancer during 2013-2017 and received care at one of three centers in Boston, MA, and New York, NY. We examined knowledge of breast cancer and treatment rationales, information preferences, and treatment receipt., Results: During 2018-2020, we interviewed 313 women (American Association for Public Opinion Research Cooperation Rates 58.4-76.5% across centers) who were 56.9% White, 23.6% Black, 14.1% Hispanic, and 5.4% other. Among the 296 included in analyses, we observed high variability in knowledge of breast cancer and treatment rationales, with a substantial number demonstrating limited knowledge despite feeling highly informed; > 25% actively avoided information. Black and Hispanic (vs. White) women consistently knew less about their cancers. Lack of understanding of treatment rationales for chemotherapy, radiation, and hormonal therapy was common but not consistently different by race and ethnicity. Understanding treatment rationale (but not cancer knowledge) was associated with treatment initiation, but small sample sizes limited in-depth examination., Conclusions: Our study highlights the need for enhanced informational support for breast cancer survivors, who are challenged with complex information during the decision-making process and beyond. More research is needed to understand how to further educate and empower diverse populations of patients with breast cancer., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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7. Perceptions of patients and medical oncologists toward biospecimen donation in the setting of abnormal breast imaging findings.
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Seah DS, Tayob N, Leone JP, Hu J, Yin J, Hughes M, Scott SM, Lederman RI, Frank E, Sohl JJ, Stadler ZK, Erick TK, Peppercorn J, Winer EP, Silverman SG, Come SE, and Lin NU
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- Biopsy, Breast, Female, Humans, Surveys and Questionnaires, Breast Neoplasms diagnostic imaging, Oncologists
- Abstract
Purpose: We sought to understand the attitudes of individuals with abnormal breast imaging findings prompting a diagnostic breast biopsy toward donation of blood, excised tissue, or percutaneous biospecimens for research, and to understand medical oncologists' attitudes toward research biospecimen collection in this population., Methods: We included individuals who presented to a single academic medical center for a clinically indicated, image-guided, percutaneous breast biopsy. We administered a survey prior to knowledge of biopsy results to assess willingness to consider, entirely for research purposes, donating blood or excess excised breast tissue, or having additional biospecimens (AB) obtained during a clinically indicated percutaneous biopsy. We also surveyed breast medical oncologists from National Cancer Institute-designated cancer centers to assess attitudes toward approaching patients for biospecimen research., Results: Overall, 53/63 patients responded to the survey; 70% would consider donating blood, 85% would consider donating excess excised breast tissue, and 32% would consider having AB obtained during a clinically indicated biopsy. Main motivating factors for considering AB included contributing to scientific knowledge and return of study or biopsy results, whereas anxiety and the potential discomfort were the main dissuading factors. Among 191 medical oncologists, most were very comfortable (59.2%), or somewhat comfortable (32.5%) asking patients to have AB obtained during a clinically indicated breast biopsy. Medical oncologists reported hesitancy to refer a patient for AB due to potential pain/discomfort, and other procedure risks., Conclusions: Only one-third of individuals with breast imaging findings would consider consenting to AB during a diagnostic biopsy, whereas most were open to donating blood or excess excised breast tissue. Most medical oncologists would be comfortable asking patients to have AB obtained during the biopsy. Understanding patients' and oncologists' baseline attitudes may inform the design and approach to breast biospecimen-based research., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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8. Perceptions of patients with early stage breast cancer toward research biopsies.
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Seah DS, Leone JP, Openshaw TH, Scott SM, Tayob N, Hu J, Lederman RI, Frank ES, Sohl JJ, Stadler ZK, Erick TK, Silverman SG, Peppercorn JM, Winer EP, Come SE, and Lin NU
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- Academies and Institutes statistics & numerical data, Adult, Aged, Aged, 80 and over, Analysis of Variance, Biopsy psychology, Blood Donors statistics & numerical data, Breast Neoplasms psychology, Cancer Care Facilities statistics & numerical data, Female, Health Services Accessibility, Humans, Middle Aged, Neoplasm Staging, Socioeconomic Factors, Surveys and Questionnaires, Tissue and Organ Procurement, Attitude, Biomedical Research, Breast pathology, Breast Neoplasms pathology, Tissue Donors psychology
- Abstract
Background: The objective of this study was to describe the perspective of patients with early breast cancer toward research biopsies. The authors hypothesized that more patients at academic sites than at community-based sites would be willing to consider these procedures., Methods: In total, 198 patients with early stage breast cancer were recruited from 3 academic centers (n = 102) and from 1 community oncology practice (n = 96). The primary objective was to compare the proportion of patients willing to consider donating excess tissue biospecimens from surgery, from a clinically indicated breast biopsy, or from a research purposes-only biopsy (RPOB) between practice types., Results: Most patients (93% at academic sites, 94% at the community oncology site) said they would consider donating excess tissue from surgery for research. One-half of patients from academic or community sites would consider donating tissue from a clinically indicated breast biopsy. On univariate analysis, significantly fewer patients from academic sites would consider an RPOB (22% at academic sites, 42% at the community site; P = .003); however, this difference was no longer significant on multivariate analysis (P = .96). Longer transportation times and unfavorable prior experiences were associated with less willingness to consider an RPOB on multivariate analysis. Significantly fewer patients from academic sites (14%) than from the community site (35%) would consider a research biopsy in a clinical trial (P = .04). Contributing to scientific knowledge, return of results, and a personal request by their physician were the strongest factors influencing patients' willingness to undergo research biopsies., Conclusions: The current results rejected the hypothesis that more patients with early breast cancer at academic sites would be willing to donate tissue biospecimens for research compared with those at community oncology sites. These findings identify modifiable factors to consider in biobanking studies and clinical trials., (© 2020 American Cancer Society.)
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- 2021
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9. Perceptions of Oncologists About Sharing Clinic Notes with Patients.
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McCleary NJ, Healey MJ, Weng S, Song AB, Lederman RI, Ramelson HZ, Wagner AJ, and Abel GA
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- Adult, Female, Humans, Male, Middle Aged, Perception, Physician-Patient Relations, Electronic Health Records standards, Oncologists
- Abstract
In a large survey ( n = 809) conducted to understand how oncologists differ from nononcologists regarding routinely sharing visit notes with patients, oncologists were less likely to agree patient safety would improve ( p = .03) or that patients would be offended after reading notes ( p = .01); however, they agreed with nononcologists that sharing notes would lead to less candid documentation (69% vs. 73%; p = .39). Oncologists share a high level of worry about the impact of sharing notes on documentation practices, a concern that will need to be addressed as the practice of sharing visit notes expands to cancer care., Competing Interests: Disclosures of potential conflicts of interest may be found at the end of this article., (© AlphaMed Press 2018.)
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- 2019
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10. The Grief of Mothers After the Sudden Unexpected Death of Their Infants.
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Goldstein RD, Lederman RI, Lichtenthal WG, Morris SE, Human M, Elliott AJ, Tobacco D, Angal J, Odendaal H, Kinney HC, and Prigerson HG
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- Adult, Anger, Confusion, Female, Humans, Infant, Role, South Africa, Surveys and Questionnaires, United States, Young Adult, Grief, Mothers psychology, Sudden Infant Death
- Abstract
: media-1vid110.1542/5741323271001PEDS-VA_2017-3651 Video Abstract BACKGROUND: The loss of a child is associated with elevated grief severity, and sudden infant death syndrome (SIDS) is the leading cause of postneonatal mortality in the United States. The diagnosis of prolonged grief disorder (PGD) has gained broader acceptance and use. Little is known about PGD in mothers after SIDS., Methods: Between May 2013 and July 2016, we assessed 49 SIDS-bereaved mothers living in informal settlements near Cape Town, South Africa, and on the Pine Ridge Indian Reservation and 359 SIDS-bereaved mothers affiliated with SIDS parent-support organizations in the United States, United Kingdom, Australia, New Zealand, and the Netherlands. We examined PGD symptom severity and diagnostic prevalence rates between the samples and other significant grief indicators during the period 2 to 48 months after the deaths of their infants., Results: Extremely high, persistent, and similar rates of PGD were found in both samples at every time interval. The prevalence of PGD was 50.0% in either sample (mean months from loss: 20.5 vs 24.9). Daily, intrusive emotional pain or yearning was found in 68.1% of subjects; yearning was significantly associated with emotional pain ( P < .0001). Role confusion and anger were the most prevalent symptoms, reported by the majority at every time interval. Rates of role confusion, anger, and diminished trust in others remained constant. Acceptance was less prevalent than other grief indicators at every interval., Conclusions: Severe symptoms and heightened risk for PGD was seen in mothers after their infants died of SIDS, with discernible symptom profiles. Given their involvement with families after SIDS, pediatricians may have a unique role in identifying this problem and helping address its consequences., Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose., (Copyright © 2018 by the American Academy of Pediatrics.)
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- 2018
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11. Working up rectal bleeding in adult primary care practices.
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Weingart SN, Stoffel EM, Chung DC, Sequist TD, Lederman RI, Pelletier SR, and Shields HM
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- Adult, Aged, Aged, 80 and over, Community Health Centers statistics & numerical data, Diagnostic Techniques and Procedures, Female, Hospitals, Teaching statistics & numerical data, Humans, Male, Medical History Taking, Middle Aged, Physical Examination, Socioeconomic Factors, Urban Health Services statistics & numerical data, Gastrointestinal Hemorrhage etiology, Guideline Adherence, Practice Guidelines as Topic, Primary Health Care organization & administration, Primary Health Care statistics & numerical data
- Abstract
Rationale, Aims and Objectives: Variation in the workup of rectal bleeding may result in guideline-discordant care and delayed diagnosis of colorectal cancer. Accordingly, we undertook this study to characterize primary care clinicians' initial rectal bleeding evaluation., Methods: We studied 438 patients at 10 adult primary care practices affiliated with three Boston, Massachusetts, academic medical centres and a multispecialty group practice, performing medical record reviews of subjects with visit codes for rectal bleeding, haemorrhoids or bloody stool. Nurse reviewers abstracted patients' sociodemographic characteristics, rectal bleeding-related symptoms and components of the rectal bleeding workup. Bivariate and multivariable logistic regression models examined factors associated with guideline-discordant workups., Results: Clinicians documented a family history of colorectal cancer or polyps at the index visit in 27% of cases and failed to document an abdominal or rectal examination in 21% and 29%. Failure to order imaging or a diagnostic procedure occurred in 32% of cases and was the only component of the workup associated with guideline-discordant care, which occurred in 27% of cases. Compared with patients at hospital-based teaching sites, patients at urban clinics or community health centres had 2.9 (95% confidence interval 1.3-6.3) times the odds of having had an incomplete workup. Network affiliation was also associated with guideline concordance., Conclusion: Workup of rectal bleeding was inconsistent, incomplete and discordant with guidelines in one-quarter of cases. Research and improvements strategies are needed to understand and manage practice and provider variation., (© 2016 John Wiley & Sons, Ltd.)
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- 2017
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12. Delayed Workup of Rectal Bleeding in Adult Primary Care: Examining Process-of-Care Failures.
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Weingart SN, Stoffel EM, Chung DC, Sequist TD, Lederman RI, Pelletier SR, and Shields HM
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- Adult, Boston, Humans, International Classification of Diseases, Malpractice, Colorectal Neoplasms complications, Colorectal Neoplasms diagnosis, Delayed Diagnosis, Gastrointestinal Hemorrhage etiology, Primary Health Care
- Abstract
Background: Although delayed colorectal cancer diagnoses figure prominently in medical malpractice claims, little is known about the quality of primary care clinicians' workup of rectal bleeding., Methods: In this study, 438 patients were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for rectal bleeding, hemorrhoids, and blood in the stool at 10 Boston adult primary care practices. Following nurse chart abstraction, physician reviewers assessed the overall quality of care and key care processes. Subjects' characteristics and physician reviewers' processes-of-care assessments were tabulated, and logistic regression models were used to examine the association of process failures with overall quality and guideline concordance., Results: Although reviewers judged the overall quality of care to be good or excellent in 337 (77%) of 438 cases, 312 (71%) patients experienced at least one process-of-care failure in the workup of rectal bleeding. Clinicians failed to obtain an adequate family history in 38% of cases, complete a pertinent physical exam in 23%, and order laboratory tests in 16%. Failure to order or perform tests, or to make follow-up plans were associated with increased odds of poor or fair care. Guideline concordance bore little relationship with quality judgments. Reviewers judged that 128 delays could have been reduced or prevented., Conclusion: Process-of-care failures among adult primary care patients with rectal bleeding were frequent and associated with fair or poor quality. Educating practitioners and creating systems to ensure adequate history taking, physical examination, and processes for ordering, performing, and interpreting diagnostic tests may improve performance., (Copyright © 2016 The Joint Commission. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
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13. Increasing response rates from physicians in oncology research: a structured literature review and data from a recent physician survey.
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Martins Y, Lederman RI, Lowenstein CL, Joffe S, Neville BA, Hastings BT, and Abel GA
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- Health Care Surveys methods, Humans, Massachusetts, Medical Oncology, Telephone, Health Care Surveys statistics & numerical data, Persuasive Communication, Physicians
- Abstract
Although the physician survey has become an important tool for oncology-focused health services research, such surveys often achieve low response rates. This mini-review reports the results of a structured review of the literature relating to increasing response rates for physician surveys, as well as our own experience from a survey of physicians as to their referral practices for suspected haematologic malignancy in the United States. PubMed and PsychINFO databases were used to identify methodological articles assessing factors that influence response rates for physician surveys; the results were tabulated and reviewed for trends. We also analysed the impact of a follow-up telephone call by a physician investigator to initial non-responders in our own mailed physician survey, comparing the characteristics of those who responded before vs after the call. The systematic review suggested that monetary incentives and paper (vs web or email) surveys increase response rates. In our own survey, follow-up telephone calls increased the response rate from 43.7% to 70.5%, with little discernible difference in the characteristics of early vs later responders. We conclude that in addition to monetary incentives and paper surveys, physician-to-physician follow-up telephone calls are an effective method to increase response rates in oncology-focused physician surveys.
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- 2012
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14. Prevention-oriented life styles and diffusion of cholesterol screening and awareness: Massachusetts behavioral risk factor survey, 1987-1991.
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Stein AD and Lederman RI
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- Adult, Humans, Massachusetts, Middle Aged, Risk Factors, Cholesterol blood, Life Style, Mass Screening statistics & numerical data
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Universal screening of the adult population for detection of elevated serum cholesterol has been recommended. We examined the relation of eight risk factors for morbidity and mortality (hypertension, overweight, inactivity, tobacco use, safety belt nonuse, binge alcohol consumption, driving after alcohol consumption, and chronic alcohol consumption) to adoption of cholesterol screening and to awareness of cholesterol level. Data were collected through the Massachusetts Behavioral Risk Factor Surveillance System between 1987 and 1991 (mean number of respondents interviewed annually, 1240). We compared trends in prevalence of cholesterol screening and awareness within risk groups defined on the basis of the presence or absence of each risk factor. Cholesterol screening prevalence increased from 46.8% in 1987 to 67.9% in 1991. Overweight and hypertensive respondents were more likely to have been screened than nonoverweight or normotensive respondents; for the other six risk factors, individuals at increased risk were less likely to have been screened. The difference in cholesterol screening prevalence between increased-risk and lower-risk respondents increased between 1987-1988 and 1990-1991 for four risk factors. Prevalence of awareness of cholesterol level increased from 7.8% in 1987 to 35.4% in 19991. Trends by risk status were comparable to those observed for cholesterol screening. Individuals already motivated toward a preventive life style appear to be those most likely to avail themselves of a new prevention possibility.
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- 1996
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15. Reproducibility of the women's module of the Behavioral Risk Factor Surveillance System questionnaire.
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Stein AD, Lederman RI, and Shea S
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- Adolescent, Adult, Aged, Breast Neoplasms mortality, Cross-Sectional Studies, Female, Humans, Hysterectomy statistics & numerical data, Incidence, Massachusetts, Middle Aged, Minority Groups statistics & numerical data, Pregnancy, Prenatal Care statistics & numerical data, Reproducibility of Results, Uterine Cervical Neoplasms mortality, Breast Neoplasms prevention & control, Health Behavior, Mass Screening statistics & numerical data, Population Surveillance, Uterine Cervical Neoplasms prevention & control
- Abstract
The Behavioral Risk Factor Surveillance System (BRFSS) is designed to provide statewide estimates of the prevalence of preventive health practices, including screening. We assessed the reproducibility of responses to the women's health module, which covers breast and cervical cancer screening, hysterectomy, and pregnancy. A random sample of women in Massachusetts (n = 91; response rate for the repeat interview, 70.0%) and a separate random sample of minority women in the state (n = 179; response rate for the repeat interview, 69.4%) were interviewed by telephone twice, 21 to 94 days apart. Differences across administrations in mean prevalence of screening were small. Concordance exceeded 85% for almost all the variables examined, but tended to be lower for nonwhite respondents. After correction for agreement occurring by chance, moderate to excellent values of kappa (range, 0.41 to 0.86) were observed. The women's health module of the BRFSS questionnaire yields highly consistent group mean estimates of prevalence when administered repeatedly to the same individuals. Individual reproducibility is excellent, but may be reduced among minority respondents.
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- 1996
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16. Reproducibility of responses to telephone interviews: demographic predictors of discordance in risk factor status.
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Stein AD, Courval JM, Lederman RI, and Shea S
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- Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Demography, Female, Forecasting, Humans, Male, Massachusetts epidemiology, Middle Aged, Prevalence, Random Allocation, Reproducibility of Results, Risk Factors, Socioeconomic Factors, Interviews as Topic methods, Risk-Taking, Telephone
- Abstract
The reproducibility of responses to the Behavioral Risk Factor Surveillance System questionnaire was examined across the demographic strata used by the Centers for Disease Control and Prevention and state health departments for reporting prevalence estimates (specifically age, sex, income, employment, and marital status), as well as race/ethnicity, which has been previously examined. The authors administered the questionnaire twice, 21-94 days apart, to randomly selected residents of Massachusetts (response rates: first administration, 68% of eligible households; second administration, 68% of persons who completed the first interview). Initial interviews were conducted in March and October 1992. Among 448 respondents to both interviews, group mean distributions of seven demographic characteristics and 19 risk factors were highly consistent across the two interviews. Discordance in individual risk factor status ranged from 1.2% to 21.8% (median, 7.8%) and was symmetric in direction, i.e., as many respondents were considered at increased risk on the basis of the first interview and at low risk on the basis of the second interview as the reverse. Kappas ranged from 0.30 to 0.90 (median, 0.75). Education, household income, and interval between administrations were not associated with prevalence of discordance for any risk factor. Sex, age, race/ethnicity, marital status, and employment status were each predictive of variation in discordance for one or more risk factors, but no consistent effect of any individual demographic characteristic across risk factors was observed. The questionnaire has relatively uniform and generally good reproducibility across all demographic strata used for monitoring the Health Objectives for Year 2000 and other chronic disease surveillance activities.
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- 1995
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17. The Behavioral Risk Factor Surveillance System questionnaire: its reliability in a statewide sample.
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Stein AD, Lederman RI, and Shea S
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- Adult, Female, Humans, Male, Massachusetts, Middle Aged, Prevalence, Random Allocation, Reproducibility of Results, Risk Factors, Sampling Studies, Black or African American statistics & numerical data, Health Behavior ethnology, Health Status Indicators, Hispanic or Latino statistics & numerical data, Population Surveillance methods, Surveys and Questionnaires standards, White People statistics & numerical data
- Abstract
The reliability of the Behavioral Risk Factor Surveillance System questionnaire was assessed in a random sample of adults (n = 122) and a separate sample of Black and Hispanic adults (n = 200) in Massachusetts. The questionnaire was administered twice, 21 to 44 days apart, by telephone (210 completed reinterviews, 65% response rate for second administration). There were no statistically significant differences in the distribution of demographic or risk factor variables across administrations. Individual-level reliability (kappa for categorical variables, correlation for continuous variables) for demographic characteristics was more than 0.80 for White respondents and more than 0.60 for Black and Hispanic respondents. Employment and income were reported less consistently than other variables. Reliability coefficients for behavioral risk factors were generally above 0.70. Exceptions were variables with extreme distributions. These data support the use of the Behavioral Risk Factor Surveillance System questionnaire for surveillance and research.
- Published
- 1993
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18. Maternal ethnicity and birthweight among blacks.
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Friedman DJ, Cohen BB, Mahan CM, Lederman RI, Vezina RJ, and Dunn VH
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- Adult, Africa ethnology, Black People, Female, Haiti ethnology, Hispanic or Latino, Humans, Infant, Low Birth Weight, Infant, Newborn, Massachusetts, Pregnancy, Risk Factors, West Indies ethnology, Black or African American, Birth Weight, Ethnicity, Mothers
- Abstract
This paper examines the association of ethnicity and birthweight, adjusted for other maternal and infant characteristics, among black women who gave birth in Massachusetts from 1987 through 1989. Data are drawn from the standard certificate of live birth, which includes questions on race and ethnicity/ancestry as well as birthweight; maternal sociodemographic and biological characteristics; access to prenatal care; and infant characteristics. The study cohort consists of 18,571 black infants and a comparison group of 206,358 non-Hispanic white infants. Infants whose mothers reported their race as black were further categorized into six ethnic groups: American, Haitian, West Indian, Cape Verdean, Hispanic, and other black. In addition to descriptive analyses, we used multiple linear regression to measure the association between ethnicity, other characteristics, and birthweight; and we used multiple logistic regression to measure the odds ratio of low birthweight (ranging from 500 g to 2499 g) for the six black ethnic groups, adjusted for other characteristics. Results indicate that Americans have lower mean birthweight and generally higher levels of risk than other black ethnic groups. Compared to the reference group of non-Hispanic whites, Americans (OR = 1.49), other blacks (OR = 1.41), and West Indians (OR = 1.37) have significantly elevated relative risks of low birthweight.
- Published
- 1993
19. Ethnic variation and maternal risk characteristics among blacks--Massachusetts, 1987 and 1988.
- Author
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Friedman DJ, Cohen BB, Dunn VH, Lederman RI, Mahan C, Spivak HR, and Trudeau EB
- Subjects
- Adult, Female, Haiti ethnology, Hispanic or Latino, Humans, Massachusetts, Middle Aged, Pregnancy, Pregnancy Outcome ethnology, West Indies ethnology, Black or African American, Maternal Behavior ethnology
- Published
- 1991
20. Temporary disability among independently living adults with major disabling conditions.
- Author
-
Meyers AR, Branch LG, and Lederman RI
- Subjects
- Adult, Epidemiologic Methods, Female, Health Status, Humans, Male, Activities of Daily Living, Disability Evaluation
- Published
- 1988
- Full Text
- View/download PDF
21. A prospective evaluation of the effect of managed care on medical care utilization among severely disabled independently living adults.
- Author
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Meyers AR, Cupples A, Lederman RI, Branch LG, Feltin M, Master RJ, Nicastro D, Glover M, and Kress D
- Subjects
- Adult, Boston, Female, Health Status, Humans, Longitudinal Studies, Male, Regression Analysis, Social Support, Activities of Daily Living, Delivery of Health Care, Disabled Persons, Emergency Service, Hospital statistics & numerical data, Hospitalization, Managed Care Programs
- Abstract
We conducted an 18-month longitudinal evaluation of a model-managed medical care program for severely disabled, independently living adults. Regression analyses using an additive model (no interaction effects) suggest that persons in the study group did not have statistically significantly different utilization experiences than members of the comparison group. Regression analyses that include interaction effects suggest that, for certain segments of the cohort, the study group's utilization experience was significantly lower than that of members of the comparison group. Persons in the study group with higher baseline emergency room (ER) utilization had significantly fewer hospital admissions (P = 0.0055). The participants with better self-assessments of health experienced significantly fewer hospital days per person (P = 0.0075) and days per person hospitalized (P = 0.0056), and persons with organizational affiliations reported significantly fewer ER visits (P = 0.0264).
- Published
- 1987
- Full Text
- View/download PDF
22. Rehospitalization and spinal cord injury: cross-sectional survey of adults living independently.
- Author
-
Meyers AR, Feltin M, Master RJ, Nicastro D, Cupples A, Lederman RI, and Branch LG
- Subjects
- Adolescent, Adult, Cross-Sectional Studies, Disabled Persons psychology, Female, Health Services statistics & numerical data, Health Status, Humans, Length of Stay, Male, Massachusetts, Middle Aged, Quality of Life, Risk, Spinal Cord Injuries psychology, Activities of Daily Living, Patient Readmission, Spinal Cord Injuries complications
- Abstract
A cross-sectional survey of 96 people living independently with spinal cord injuries (SCI) in Eastern Massachusetts shows that 57% had been hospitalized at least once in the year before the survey. Sample means were 1.0 admissions and 16.0 days/person/year. Eight percent of the sample (eight persons) accounted for 22% of admissions and 59% of total hospital days. For those hospitalized, the mean was 1.7 admissions and 45.1 days/person/year. Mean length-of-stay was 34.7 days/admission. Multiple regression analysis shows that three variables appear to be independently related to increased numbers of admissions: self-assessment of health; place of residence; and age (younger respondents at higher risk). One variable is independently associated with total days of hospitalization: leaving home at least once daily (as opposed to less frequently) is associated with lower risk. There were no statistically significant relationships between either numbers of hospitalizations or total days hospitalized and ADL or IADL status, education, employment, medical insurance, household composition, gender, age at onset of disability, time since onset of disability, substance use (alcohol, cannabis, or tobacco), level of SCI lesion, or social supports.
- Published
- 1985
23. The epidemiology of medical care utilization by severely-disabled independently-living adults.
- Author
-
Meyers AR, Cupples A, Lederman RI, Branch LG, Feltin M, Master RJ, Nicastro D, Glover M, and Kress D
- Subjects
- Activities of Daily Living, Female, Health Status, Hospitalization, Humans, Length of Stay, Male, Prospective Studies, Disabled Persons, Health Services statistics & numerical data
- Abstract
A prospective study of the medical care utilization experience of 205 severely-disabled independently-living adults in Eastern Massachusetts shows that there was a mean of 0.83 +/- 1.26 hospital admissions, 9.9 +/- 22.7 hospital days, 1.5 +/- 2.31 emergency room (ER) visits, and 26.88 +/- 44.4 outpatient contacts per person per year. Among those hospitalized, the mean experience was 16.2 +/- 27.1 days per person per year; mean length-of-stay was 9.3 +/- 14.7 days per admission. Regression analysis indicates that those with spinal cord injuries as major disabling conditions were significantly more likely to be hospitalized. So were those with lower self-assessments of health, higher levels of depressions, and more baseline ER visits. Self-assessment of health is a significant predictor of hospital days for the total cohort (including those with no admissions); so are age at onset of disability (greater age; higher risk), and bed disability days in the month before the baseline survey (more disability days; higher risk). Among those hospitalized, the total number of days hospitalized is significantly related to both age at onset of disability (later onset; more days) and baseline days hospitalized (greater number; more days). Lengths-of-stay are significantly related to two factors; age and age at onset of disability (in both cases, greater age associated with longer stays). Prior ER visits are a significant predictor of subsequent ER visits (more baseline; more subsequent); so are respondents' reported satisfaction with their participation in their medical care (lower reported satisfaction; more ER visits), organizational affiliations, and frequencies of contacts with friends or relatives. Higher levels of social interaction (i.e. organizational affiliation and more frequent social contacts) were associated with more ER visits. Prior contacts with physicians, nurse-practitioners, or physician-assistants was the most powerful predictor of subsequent outpatient contacts (more baseline; more subsequent). There were also significant relationships between subsequent contacts and respondents' assessments of their health relative to others with similar disabilities (relatively worse health; more contacts), age (greater age; more contacts), and baseline ER visits (more visits; more contacts).
- Published
- 1988
- Full Text
- View/download PDF
24. Mandatory seatbelt law support and opposition in New England--a survey.
- Author
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Morelock S, Hingson RW, Smith RA, and Lederman RI
- Subjects
- Adolescent, Adult, Age Factors, Alcohol Drinking, Automobile Driving, Educational Status, Humans, Income, Interviews as Topic, Marriage, Middle Aged, New England, Attitude, Legislation as Topic, Seat Belts
- Abstract
Less than one-fifth of the U.S. population consistently wears automobile seatbelts. Automatic seatbelts or air bags will be required in all new cars, unless States whose total population equals two-thirds of the nation's adopt mandatory seatbelt use laws by 1989, according to the U.S. Department of Transportation. In July 1984, New York State passed the first mandatory seatbelt law in the nation, followed by New Jersey, Illinois, Missouri, Michigan, and New Mexico. A telephone survey of 2,982 randomly selected drivers examined belt use and support for mandatory belt use laws in the six New England States. Drivers with little education and low income, younger drivers, and drivers who drove after heavy drinking or marijuana use, or both, were least likely to wear seatbelts. Beliefs that seatbelts are not effective in reducing injury risk and are uncomfortable were more common among those not wearing belts. Sixty percent of drivers favored a mandatory seatbelt use law. The most important predictors of opposition to a belt use law were beliefs that seatbelts are ineffective, inconvenient, and uncomfortable. Opposition was also more likely among persons who reported that they drove after marijuana use, or heavy drinking, or both, drove more miles per year, exhibited a low frequency of seatbelt use, and perceived a low probability of personal crash involvement.
- Published
- 1985
25. Alcohol, tobacco, and cannabis use by independently living adults with major disabling conditions.
- Author
-
Meyers AR, Branch LG, and Lederman RI
- Subjects
- Activities of Daily Living, Adaptation, Psychological, Adult, Female, Humans, Length of Stay, Longitudinal Studies, Male, Risk Factors, Sick Role, Social Environment, Alcohol Drinking psychology, Disabled Persons psychology, Marijuana Abuse psychology, Smoking psychology
- Abstract
Data from an 18-month prospective study of 205 adults with major disabling conditions revealed that there is a positive but not statistically significant association (p greater than .10) between respondents' scores on a scale which measures both numbers and amounts of substances (alcohol, tobacco, and cannabis) used and bed disability days. There are also nonsignificant positive relationships between scale scores and five of six measures of utilization of medical care.
- Published
- 1988
- Full Text
- View/download PDF
26. Predictors of medical care utilization by independently living adults with spinal cord injuries.
- Author
-
Meyers AR, Branch LG, Cupples LA, Lederman RI, Feltin M, and Master RJ
- Subjects
- Adult, Ambulatory Care statistics & numerical data, Boston, Humans, Length of Stay, Prospective Studies, Risk Factors, Activities of Daily Living, Health Services statistics & numerical data, Spinal Cord Injuries therapy
- Abstract
A prospective study of 87 independently living adults with spinal cord injury (SCI) as a major disabling condition showed the following average annual health care utilization rates: 1.3 hospital admissions, 16.8 days hospitalized, 1.7 emergency room (ER) visits, and 22.4 outpatient contacts (in person or by telephone). Those hospitalized (n = 66) experienced a mean of 22.2 days hospitalized per person per year. Mean length of stay (LOS) was 11.1 days per admission. Stepwise regression analysis indicated no statistically significant (p less than or equal to .05) predictors of hospital admissions. There were three independent predictors of days hospitalized (greater age, fewer years of education, and more days hospitalized during the previous year), three predictors of days hospitalized for those hospitalized only (greater age, fewer years of education, and longer hospital LOS during the previous year), one predictor of LOS (self-assessment of health), three of emergency room (ER) visits (more unmet instrumental activities of daily living needs, lack of organizational memberships, and more ER visits during the previous year), and five predictors of outpatient contacts (greater age, less satisfaction with health care providers' expressions of concern for their health, lower frequency of leaving apartments, lower levels of life satisfaction, and nonparticipation in a managed medical care demonstration project). Many predictors of health services utilization are immutable. However, changes which facilitate social interaction and changes in the organization of health services may reduce certain types of medical care utilization by people with SCI.
- Published
- 1989
- Full Text
- View/download PDF
27. Employee drinking patterns and accidental injury: a study of four New England states.
- Author
-
Hingson RW, Lederman RI, and Walsh DC
- Subjects
- Adolescent, Adult, Aged, Alcoholic Intoxication complications, Female, Humans, Male, Middle Aged, Risk, Substance-Related Disorders complications, United States, Accidents, Occupational prevention & control, Alcohol Drinking, Alcoholism complications
- Abstract
The relationship between alcohol use and accidental injury was examined in an anonymous telephone survey of 1740 randomly sampled employed adults (49% men) residing in four New England states in 1982 and 1983. Respondents reported 383 accidents requiring medical attention during the year prior to the interview, 34 involving hospitalization. Of the accidents, 41% occurred at work, 32% during recreational and other activities, 19% at home and 8% in traffic incidents. Respondents were stratified by self-reported levels of alcohol consumption and were compared on accident rates. Drinking at work was also examined for an association with accident involvement. Logistic regression analyses controlled for variability associated with age, sex, marital status, occupation and drug use. Drinking at work was not significantly or independently associated with job accidents but an average daily intake of 5+ drinks elevated the relative risk, compared with abstainers, as follows: 1.7 for any accidental injury, 3.8 for injuries requiring hospitalization and 2.0 for job-based accidental injuries. The relative risks associated with the use of other psychoactive drugs were 1.7 for work accidents and 2.4 for accident-associated hospitalizations. Of the respondents, 13% reported having ever had a drug or alcohol problem and 2% reported a current problem. Fourteen percent reported that there were counselors at their jobs to help with such problems. Of those who had ever experienced a problem, 11% had sought help from outside programs and only 4% had sought help at work.
- Published
- 1985
- Full Text
- View/download PDF
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