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1. Trends in Dual Antiplatelet Therapy of Aspirin and Clopidogrel and Outcomes in Ischemic Stroke Patients Noneligible for POINT/CHANCE Trial Treatment.

Author

Kim, Joon-Tae, Lee, Ji, Kim, Hyunsoo, Kim, Beom, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo, Kim, Jae, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi, Kim, Dong-Eog, Choi, Jay, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu, Sohn, Sung, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Ryu, Wi-Sun, Park, Kwang-Yeol, Lee, Juneyoung, Saver, Jeffrey, and Bae, Hee-Joon

Subjects
acute ischemic stroke, aspirin, clopidogrel, dual antiplatelet treatment, late‐presenting stroke, nonminor stroke, Humans, Clopidogrel, Aspirin, Male, Aged, Female, Ischemic Stroke, Dual Anti-Platelet Therapy, Platelet Aggregation Inhibitors, Registries, Middle Aged, Treatment Outcome, Aged, 80 and over, Time Factors, Japan, Secondary Prevention, Drug Therapy, Combination, Risk Factors
Abstract

BACKGROUND: Recent clinical trials established the benefit of dual antiplatelet therapy with aspirin and clopidogrel (DAPT-AC) in early-presenting patients with minor ischemic stroke. However, the impact of these trials over time on the use and outcomes of DAPT-AC among the patients with nonminor or late-presenting stroke who do not meet the eligibility criteria of these trials has not been delineated. METHODS AND RESULTS: In a multicenter stroke registry, this study examined yearly changes from April 2008 to August 2022 in DAPT-AC use for stroke patients ineligible for CHANCE/POINT (Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events/Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke) clinical trials due to National Institutes of Health Stroke Scale >4 or late arrival beyond 24 hours of onset. A total of 32 118 patients (age, 68.1±13.1 years; male, 58.5%) with National Institutes of Health Stroke Scale of 4 (interquartile range, 1-7) were analyzed. In 2008, DAPT-AC was used in 33.0%, other antiplatelets in 62.7%, and no antiplatelet in 4.3%. The frequency of DAPT-AC was relatively unchanged through 2013, when the CHANCE trial was published, and then increased steadily, reaching 78% in 2022, while other antiplatelets decreased to 17.8% in 2022 (Ptrend

Published
2024

12. Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study

Author

Ryu, Wi-Sun, Hong, Keun-Sik, Jeong, Sang-Wuk, Park, Jung E, Kim, Beom Joon, Kim, Joon-Tae, Lee, Kyung Bok, Park, Tai Hwan, Park, Sang-Soon, Park, Jong-Moo, Kang, Kyusik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Lee, Jun, Han, Moon-Ku, Park, Man Seok, Choi, Kang-Ho, Lee, Juneyoung, Saver, Jeffrey L, Lo, Eng H, Bae, Hee-Joon, and Kim, Dong-Eog

Subjects
Neurosciences, Brain Disorders, Stroke, Clinical Research, Aged, Aged, 80 and over, Circadian Rhythm, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Ischemic Stroke, Male, Middle Aged, Patient Acuity, Prospective Studies, Recovery of Function, Republic of Korea, Risk Factors, Time Factors, Treatment Outcome, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundPreclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth in rodent models with inactive phase (daytime) than active phase (nighttime) stroke onset. We aimed to examine the association of stroke onset time with presenting severity, early neurological deterioration (END), and long-term functional outcome in human ischemic stroke.Methods and findingsIn a Korean nationwide multicenter observational cohort study from May 2011 to July 2020, we assessed circadian effects on initial stroke severity (National Institutes of Health Stroke Scale [NIHSS] score at admission), END, and favorable functional outcome (3-month modified Rankin Scale [mRS] score 0 to 2 versus 3 to 6). We included 17,461 consecutive patients with witnessed ischemic stroke within 6 hours of onset. Stroke onset time was divided into 2 groups (day-onset [06:00 to 18:00] versus night-onset [18:00 to 06:00]) and into 6 groups by 4-hour intervals. We used mixed-effects ordered or logistic regression models while accounting for clustering by hospitals. Mean age was 66.9 (SD 13.4) years, and 6,900 (39.5%) were women. END occurred in 2,219 (12.7%) patients. After adjusting for covariates including age, sex, previous stroke, prestroke mRS score, admission NIHSS score, hypertension, diabetes, hyperlipidemia, smoking, atrial fibrillation, prestroke antiplatelet use, prestroke statin use, revascularization, season of stroke onset, and time from onset to hospital arrival, night-onset stroke was more prone to END (adjusted incidence 14.4% versus 12.8%, p = 0.006) and had a lower likelihood of favorable outcome (adjusted odds ratio, 0.88 [95% CI, 0.79 to 0.98]; p = 0.03) compared with day-onset stroke. When stroke onset times were grouped by 4-hour intervals, a monotonic gradient in presenting NIHSS score was noted, rising from a nadir in 06:00 to 10:00 to a peak in 02:00 to 06:00. The 18:00 to 22:00 and 22:00 to 02:00 onset stroke patients were more likely to experience END than the 06:00 to 10:00 onset stroke patients. At 3 months, there was a monotonic gradient in the rate of favorable functional outcome, falling from a peak at 06:00 to 10:00 to a nadir at 22:00 to 02:00. Study limitations include the lack of information on sleep disorders and patient work/activity schedules.ConclusionsNight-onset strokes, compared with day-onset strokes, are associated with higher presenting neurologic severity, more frequent END, and worse 3-month functional outcome. These findings suggest that circadian time of onset is an important additional variable for inclusion in epidemiologic natural history studies and in treatment trials of neuroprotective and reperfusion agents for acute ischemic stroke.

Published
2022

13. Differential impacts of admission LDL-cholesterol on early vascular outcomes by ischemic stroke subtypes

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Hyunsoo, Kim, Beom Joon, Kang, Jihoon, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Ryu, Wi-Sun, Park, Kwang-Yeol, Lee, Juneyoung, and Bae, Hee-Joon

Published
2024
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16. Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Author

Klug, Didier, Casolla, Barbara, Puy, Laurent, Coffee, Morgane, Kuchcinski, Grégory, Labreuche, Julien, van Nieuwenhuizen, Koen M., Algra, Ale, van Gelder, Isabelle C., Kappelle, L. Jaap, Rinkel, Gabriel J.E., Schutgens, Roger E.G., Khatri, Pooja, Conwit, Robin, Falcone, Guido, Elm, Jordan, Anderson, Craig S., Song, Lili, Pandian, Jeyaraj, Hart, Robert G., Sharma, Mukul, Aref, Hany, Tarhuni, Wadea, Fabregas, Joan Marti, Diener, Hans-Christoph, Endres, Matthias, Lemmens, Robin, Kwon, Sun U., Lee, Byung-Chul, Ameriso, Sebastian, Milling, Truman J., Kasner, Scott E., Mikulik, Robert, Xavier, Denis, Beer, Ronny, Toni, Danilo, Eckstein, Jens, Seiffge, David, Ferro, Jose M., Tsivgoulis, Georgios, Sharma, Sanjib K., Wei-Liou, Chia, Hohnloser, Stefan H., Katsanos, Aristeidis, Bosch, Jackie, Healey, Jeff, Eikelboom, John, Khaw, Alexander, Gladstone, David, Pikula, Aleksandra, Coutts, Shelagh, Smith, Eric E., Butcher, Ken, Field, Thalia, Gioia, Laura, Stapf, Christian, Halse, Omid, Ringleb, Peter, Enzinger, Christian, Sibon, Igor, Montaner, Joan, Caso, Valeria, Heuschmann, Peter, Lip, Gregory Y.H., Haefeli, Walter, Debette, Stefanie, Dennis, Martin S., Wyller, Torgeir Bruun, Rønning, Ole M., Eilertsen, Helle, Ihle-Hansen, Hege, Sandset, Else Charlotte, Pennlert, Johanna, Glader, Eva-Lotta, Kruuse, Christina, Wester, Per, Carlsson, Maria, Forfang, Elisabeth, Al-Shahi Salman, Rustam, Stephen, Jacqueline, Tierney, Jayne F, Lewis, Steff C, Newby, David E, Parry-Jones, Adrian R, White, Philip M, Connolly, Stuart J, Benavente, Oscar R, Dowlatshahi, Dar, Cordonnier, Charlotte, Viscoli, Catherine M, Sheth, Kevin N, Kamel, Hooman, Veltkamp, Roland, Larsen, Kristin T, Hofmeijer, Jeannette, Kerkhoff, Henk, Schreuder, Floris H B M, Shoamanesh, Ashkan, Klijn, Catharina J M, and van der Worp, H Bart

Published
2023
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18. Effect of Transport Time on the Use of Reperfusion Therapy for Patients with Acute Ischemic Stroke in Korea.

Author

Choi, Jay Chol, Kim, Joong Goo, Kang, Chul Hoo, Bae, Hee Joon, Kang, Jihoon, Lee, Soo Joo, Park, Jong Moo, Park, Tai Hwan, Cho, Yong Jin, Lee, Kyung Bok, Lee, Jun, Kim, Dong Eog, Cha, Jae Kwan, Kim, Joon Tae, Lee, Byung Chul, Lee, Ji Sung, and Kim, Anthony S

Subjects
Endovascular Treatment, Ischemic Stroke, Reperfusion, Thrombolysis, Utilization, General & Internal Medicine
Abstract

BackgroundWe investigated the association between geographic proximity to hospitals and the administration rate of reperfusion therapy for acute ischemic stroke.MethodsWe identified patients with acute ischemic stroke who visited the hospital within 12 hours of symptom onset from a prospective nationwide multicenter stroke registry. Reperfusion therapy was classified as intravenous thrombolysis (IVT), endovascular therapy (EVT), or combined therapy. The association between the proportion of patients who were treated with reperfusion therapy and the ground transport time was evaluated using a spline regression analysis adjusted for patient-level characteristics. We also estimated the proportion of Korean population that lived within each 30-minute incremental service area from 67 stroke centers accredited by the Korean Stroke Society.ResultsOf 12,172 patients (mean age, 68 ± 13 years; men, 59.7%) who met the eligibility criteria, 96.5% lived within 90 minutes of ground transport time from the admitting hospital. The proportion of patients treated with IVT decreased significantly when stroke patients lived beyond 90 minutes of the transport time (P = 0.006). The proportion treated with EVT also showed a similar trend with the transport time. Based on the residential area, 98.4% of Korean population was accessible to 67 stroke centers within 90 minutes.ConclusionThe use of reperfusion therapy for acute stroke decreased when patients lived beyond 90 minutes of the ground transport time from the hospital. More than 95% of the South Korean population was accessible to 67 stroke centers within 90 minutes of the ground transport time.

Published
2021

20. Admission LDL-cholesterol, statin pretreatment and early outcomes in acute ischemic stroke

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Kang, Jihoon, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Choi, Kang-Ho, Lee, Juneyoung, Park, Kwang-Yeol, and Bae, Hee-Joon

Published
2023
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21. Improvement in Delivery of Ischemic Stroke Treatments but Stagnation of Clinical Outcomes in Young Adults in South Korea

Author

Kim, Jonguk, Kim, Jun Yup, Kang, Jihoon, Kim, Beom Joon, Han, Moon-Ku, Lee, Jeong-Yoon, Park, Tai Hwan, Lee, Keon-Joo, Kim, Joon-Tae, Choi, Kang-Ho, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Lee, Kyungbok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi-Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Lee, Ji Sung, Lee, Juneyoung, Gorelick, Philip B., and Bae, Hee-Joon

Published
2023
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26. Frequency, management, and outcomes of early neurologic deterioration due to stroke progression or recurrence

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Choi, Kang-Ho, Lee, Juneyoung, Saver, Jeffrey L., and Bae, Hee-Joon

Published
2023
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27. Admission hyperglycemia, stroke subtypes, outcomes in acute ischemic stroke

Author

Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Kang, Jihoon, Lee, Keon-Joo, Park, Jong-Moo, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Lee, Sang-Hwa, Park, Man-Seok, Choi, Kang-Ho, Ryu, Wi-Sun, Lee, Juneyoung, Saver, Jeffrey L., and Bae, Hee-Joon

Published
2023
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28. More Than 50 Percent Reduction in LDL Cholesterol in Patients With Target LDL <70 mg/dL After a Stroke

Author

Amarenco, Pierre, Lavallée, Philippa C., Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, Bruckert, Eric, Kim, Jong S, Touboul, Pierre-Jean, Leys, Didier, Béjot, Yannick, Pico, Fernando, Touzé, Emmanuel, Ducrocq, Gregory, Abtan, Jérémy, Varenne, Olivier, Touboul, Pierre-Jean, Kemmel, Agnes, Syana, Fausta, Ledra, Manele, Nagasara, Tharani, Ledjeroud, Mervette, Samia, Bahous, Hadia, Hafirassou, Hazare, Benyoub, Jaghouni, Ikrame El, Yelles, Nessima, Zemouri, Sofia, Ladjeroud, Mervette, Kerai, Salim, In, YunJeong, Hobeanu, Cristina, Guidoux, Celine, Cabrejo, Lucie, Lapergue, Bertrand, Sabben, Candice, Gonzalez-Valcarcel, Jaime, Rigual, Ricardo, Sirimarco, Gaia, Martin-Bechet, Anna, Viedma, Elena, Avram, Ioan, Samson, Yves, Rosso, Charlotte, Crozier, Sophie, Leder, Sara, Léger, Anne, Deltour, Sandrine, Mutlu, Gurkan, Yger, Marion, Zavanone, Chiara, Baronnet, Flore, Pires, Christine, Lapergue, Bertrand, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Bourdain, Frédéric, Lopez, Delphine, Pico, Fernando, de la Tour, Laetitia Bayon, Chadenat, Marie-Laure, Duong, Duc Long, Genty, Solène, Hirel, Catherine, Mutlu, Gurkan, Nifle, Chantal, Servan, Jérôme, Stanciu, Daniela, Sudacevschi, Veronica, Tir, Mélissa, Troussière, Anne-Cécile, Yeung, Jennifer, Zeghoudi, Anne-Céline, Tidafi-Bayou, Ikram, Lachaud, Sylvain, Cho, Tae-Hee, Mechtouff, Laura, Ritzenthaller, Thomas, Derex, Laurent, Albanesi, Carlo, Ong, Elodie, Benoit, Amandine, Berhoune, Nadia, Felix, Sandra, Esteban-Mader, Maud, Sibon, Igor, Kazadi, Annabelle, Rouanet, François, Renou, Pauline, Debruxelles, Sabrina, Poli, Mathilde, Sagnier, Sharmila, Mas, Jean-Louis, Domigo, Valérie, Lamy, Catherine, Bodiguel, Eric, Grimaud, Jérôme, Bohotin, Valentin, Obadia, Michael, Sabben, Candice, Morvan, Erwan, Rodier, Gilles, Vadot, Wilfried, Hénon, Hilde, Cordonnier, Charlotte, Dumont, Frédéric, Bodenant, Marie, Lucas, Christian, Moulin, Solène, Dequatre, Nelly, Alamowitch, Sonia, Muresan, Jean-Paul, Drouet, Thomas, Gallea, Magalie, Dalloz, Marie-Amélie, Delorme, Stephen, Yger, Marion, Béjot, Yannick, Loisel, Philippe, Bonnin, Carine, Bernigal, Virginie, Osseby, Guy Victor, Hervieu-BègueMarsac, Marie, Garnier, Pierre, Accassat, Sandrine, Epinat, Magali, Varvat, Jérôme, Marinescu, Doïna, Triquenot-Bagan, Aude, Ozkul- Wermester, Ozlem, Philippeau, Frédéric, Olaru, Angel, Vieillart, Anne, Lannuzel, Annie, Demoly, Alice, Wolff, Valérie, Diaconu, Mihaela, Bataillard, Marc, Montoro, Francisco Macian, Faugeras, Frédéric, Gimenez, Laeticia, Abdallah-Lebeau, Françoise, Timsit, Serge, Viakhireva-Dovganyuk, Irina, Tirel-Badets, Anne, Merrien, François-Mathias, Goas, Philippe, Rouhart, François, Jourdain, Aurore, Guillon, Benoit, Hérissson, Fanny, Sevin-Allouet, Mathieu, Nasr, Nathalie, Olivot, Jean-Marc, Lecluse, Alderic, Marc, Guillaume, Touzé, Emmanuel, de la Sayette, Vincent, Apoil, Marion, Lin, Li, Cogez, Julien, Guettier, Sophie, Godefroy, Olivier, Lamy, Chantal, Bugnicourt, Jean-Marc, Taurin, Grégory, Mérienne, Marc, Gere, Julien, Chessak, Anne-Marie, Habet, Tarik, Ferrier, Anna, Bourgois, Nathalie, Minier, Dominique, Caillier-Minier, Marie, Contégal- Callier, Fabienne, Vion, Philippe, Vaschalde, Yvan, Amrani, Mohammed El, Emilie, Zuber, Mathieu, Bruandet, Marie, Join- Lambert, Claire, Garcia, Pierre-Yves, Serre, Isabelle, Faucheux, Jean-Marc, Radji, Fatia, Leca-Radu, Elena, Debroucker, Thomas, Cumurcuc, Rodica, Cakmak, Serkan, Peysson, Stéphane, Ellie, Emmanuel, Bernady, Patricia, Moulin, Thierry, Montiel, Paola, Revenco, Eugeniu, Decavel, Pierre, Medeiros, Elisabeth, Bouveret, Myriam, Louchart, Pierre, Vaduva, Claudia, Couvreur, Grégory, Sartori, Eric, Carpentier, Alnajar, Levasseur, Michèle, Louchart, Pierre, Faucheux, Jean-Marc, Neau, Philippe, Vandamme, Xavier, Meresse, Isabelle, Stantescu, Bataillard, Marc, Ozsancak, Canan, Beauvais, Katell, Auzou, Pascal, Amevigbe, Joséphine, Vuillemet, Francis, Dugay-Arentz, Marie-Hélène, Carelli, Gabriela, Martinez, Mikel, Maillet-Vioud, Marcel, Escaillas, Jean-Pierre, Chapuis, Stéphane, Tardy, Jean, Manchon, Eric, Varnet, Olivier, Kim, Yong-Jae, Chang, Yoonkyung, Song, Tae-Jin, Kim, Jong Sung, Han, Jung-Hoon, Noh, Kyung Chul, Lee, Eun-Jae, Kang, Dong-Wha, Kwon, Sun Uck, Kwon, Boseoung, Park, Seongho, Lee, Dongwhane, Kwon, Hyuk Sung, Jeong, Daeun, Lee, MinHwan, Kim, Joonggoo, Lee, Hanbin, Nam, Hyo Jung, Lee, Sang Hun, Kim, Bum Joon, Cha, Jae-kwan, Kim, DaeHyun, Kim, Rae Young, Sohn, Sang Wuk, Shim, Dong-Hyun, Lee, Hyungjin, Nah, Hyun-Wook, Sung, Sang Min, Lee, Kyung Bok, Yoon Lee, Jeong, Yoon, Jee Eun, Kim, Eung-Gyu, Seo, Jung Hwa, Kim, Yong-Won, Hwang, Yangha, Park, Man Seok, Kim, Joon-Tae, Choi, Kang-Ho, Nam, Hyo Suk, Heo, Ji Hoe, Kim, Young Dae, Hwang, In Gun, Park, Hyung Jong, Kim, Kyoung Sub, Baek, Jang Hyun, Song, Dong Beom, Yoo, Joon Sang, Park, Jong-Moo, Kwon, Ohyun, Lee, Woong-Woo, Lee, Jung-Ju, Kang, Kyusik, Kim, Byung Kun, Lim, Jae-Sung, Oh, Mi Sun, Yu, Kyung-Ho, Hong, Bora, Jang, Mihoon, Jang, Seyoung, Jin, Jung Eun, Kim, Jei, Jeong, Hye Seon, Hong, Keun Sik, Park, Hong Kyun, Cho, Yong Jin, Bang, Oh Young, Seo, Woo-Keun, and Chung, Jongwon

Published
2023
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29. Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques

Author

Lee, Byung-Chul, primary, Gin, Ashley, additional, Wu, Chuanfeng, additional, Singh, Komudi, additional, Grice, Max, additional, Mortlock, Ryland, additional, Abraham, Diana, additional, Fan, Xing, additional, Zhou, Yifan, additional, AlJanahi, Aisha, additional, Choi, Uimook, additional, DeRavin, Suk See, additional, Shin, Taehoon, additional, Hong, Sogun, additional, and Dunbar, Cynthia E., additional

Published
2024
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31. A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

Author

Shin, Tae-Hoon, Zhou, Yifan, Chen, Shirley, Cordes, Stefan, Grice, Max Z., Fan, Xing, Lee, Byung-Chul, Aljanahi, Aisha A., Hong, So Gun, Vaughan, Kelli L., Mattison, Julie A., Kohama, Steven G., Fabre, Margarete A., Uchida, Naoya, Demirci, Selami, Corat, Marcus A. F., Métais, Jean-Yves, Calvo, Katherine R., Buscarlet, Manuel, Natanson, Hannah, McGraw, Kathy L., List, Alan F., Busque, Lambert, Tisdale, John F., Vassiliou, George S., Yu, Kyung-Rok, and Dunbar, Cynthia E.

Published
2022
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34. Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use

Author

Kang, You-Ri, Kim, Joon-Tae, Lee, Ji Sung, Kim, Beom Joon, Kang, Kyusik, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Lee, Kyung Bok, Lee, Jun, Hong, Keun-Sik, Cho, Yong-Jin, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Kim, Dong-Eog, Ryu, Wi-Sun, Choi, Jay Chol, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Sohn, Sung Il, Hong, Jeong-Ho, Park, Man-Seok, Choi, Kang-Ho, Cho, Ki-Hyun, Park, Jong-Moo, Lee, Sang-Hwa, Lee, Juneyoung, and Bae, Hee-Joon

Published
2022
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38. Statins

Author

Lee, Minwoo, Lee, Byung-Chul, Lee, Seung-Hoon, editor, and Kang, Min Kyoung, editor

Published
2021
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40. Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles

Author

Iacobazzi, Rosa Maria, Vischio, Fabio, Arduino, Ilaria, Canepa, Fabio, Laquintana, Valentino, Notarnicola, Maria, Scavo, Maria Principia, Bianco, Giusy, Fanizza, Elisabetta, Lopedota, Angela Assunta, Cutrignelli, Annalisa, Lopalco, Antonio, Azzariti, Amalia, Curri, Maria Lucia, Franco, Massimo, Giannelli, Gianluigi, Lee, Byung Chul, Depalo, Nicoletta, and Denora, Nunzio

Published
2022
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44. Temporal Trends in Stroke Management and Outcomes between 2011 and 2020: Results from a Nationwide Multicenter Registry

Author

Park, Tai Hwan, primary, Hong, Keun-Sik, additional, Cho, Yong-Jin, additional, Ryu, Wi-Sun, additional, Kim, Dong-Eog, additional, Park, Man-Seok, additional, Choi, Kang-Ho, additional, Kim, Joon-Tae, additional, Kang, Jihoon, additional, Kim, Beom-Joon, additional, Han, Moon-Ku, additional, Lee, Jun, additional, Cha, Jae-Kwan, additional, Kim, Dae-Hyun, additional, Kim, Jae Guk, additional, Lee, Soo Joo, additional, Kwon, Jee-Hyun, additional, Kim, Wook-Joo, additional, Shin, Dong-Ick, additional, Yum, Kyu Sun, additional, Sohn, Sung Il, additional, Hong, Jeong-Ho, additional, Choi, Jay Chol, additional, Lee, Byung-Chul, additional, Yu, Kyung-Ho, additional, Oh, Mi-Sun, additional, Park, Jong-Moo, additional, Kang, Kyusik, additional, Lee, Kyungbok, additional, Lee, Sang-Hwa, additional, Jeong, Hae-Bong, additional, Park, Kwang-Yeol, additional, Lee, Ji Sung, additional, Lee, Juneyoung, additional, Gorelick, Philip B., additional, and Bae, Hee-Joon, additional

Published
2024
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46. Abstract TMP107: Persistent Beta-Blocker Use and Mortality Reduction in Acute Ischemic Stroke Patients

Author

Lee, Keon-Joo, primary, Kim, Seong-eun, additional, Guk, Hyung Seok, additional, Kim, Beom Joon, additional, Han, Moon-Ku, additional, Kim, Joon-Tae, additional, Choi, Kangho, additional, Shin, Dong-Ick, additional, Cha, Jae-kwan, additional, Kim, Dae Hyun, additional, Kim, Dong-Eog, additional, Park, Jong-moo, additional, Kang, Kyusik, additional, Lee, Soo Joo, additional, Kim, Jae G, additional, Oh, Mi-Sun, additional, Yu, Kyung-Ho, additional, Lee, Byung-Chul, additional, Hong, Keun-Sik, additional, Cho, Yong-jin, additional, Choi, Jay Chol, additional, Park, Tai H, additional, Park, Sang-Soon, additional, Kwon, Jee-Hyun, additional, Kim, Wook-Joo, additional, Lee, Kyungbok, additional, Lee, Jun, additional, Lee, Ji Sung, additional, Lee, Juneyoung, additional, Bae, Hee-Joon, additional, and Kim, Nakhoon, additional

Published
2024
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47. A Relaxor-Ferroelectric Pmn-Pzt Thin-Film-Based Drop-on-Demand Printhead for Bioprinting Applications with High Piezoelectricity and Low Heat Dissipation

Author

Park, Jin Soo, primary, Huh, Keun Young, additional, Kim, Min-Seok, additional, Jung, Soo Young, additional, Park, Jung Ho, additional, Kim, Soo Jin, additional, Jang, Ho Won, additional, Hwang, Kyeong Seob, additional, Kim, Hong Nam, additional, Kim, Tae Geun, additional, Baek, Seung-Hyub, additional, and Lee, Byung Chul, additional

Published
2024
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48. Brain Frailty and Outcomes of Acute Minor Ischemic Stroke With Large-Vessel Occlusion

Author

Park, Je-Woo, primary, Kim, Joon-Tae, additional, Lee, Ji Sung, additional, Kim, Beom Joon, additional, Yoo, Joonsang, additional, Han, Jung Hoon, additional, Kim, Bum Joon, additional, Kim, Chi Kyung, additional, Kim, Jae Guk, additional, Baik, Sung Hyun, additional, Park, Jong-Moo, additional, Kang, Kyusik, additional, Lee, Soo Joo, additional, Park, Hyungjong, additional, Cha, Jae-Kwan, additional, Park, Tai Hwan, additional, Lee, Kyungbok, additional, Lee, Jun, additional, Hong, Keun-Sik, additional, Lee, Byung-Chul, additional, Kim, Dong-Eog, additional, Choi, Jay Chol, additional, Kwon, Jee-Hyun, additional, Shin, Dong-Ick, additional, Sohn, Sung Il, additional, Lee, Sang-Hwa, additional, Ryu, Wi-Sun, additional, Lee, Juneyoung, additional, and Bae, Hee-Joon, additional

Published
2024
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50. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Author

Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M, Chen, Christopher P L H, Dondaine, Thibaut, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kang, Yeonwook, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Kuchcinski, Gregory, Lam, Bonnie Y K, Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D J, Mendyk, Anne-Marie, Mok, Vincent C T, Oh, Mi Sun, van Oostenbrugge, Robert J, Roussel, Martine, Shi, Lin, Staals, Julie, del C Valdés-Hernández, Maria, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J E, Zhao, Lei, Biesbroek, J Matthijs, and Biessels, Geert Jan

Published
2021
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