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4. Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong,andPeaonia lactiflora

Author

Bak, Su-Bin, Choi, Hansol, Kim, Gyoung-Deuck, Kim, Ju Gyeong, Kwon, Da-Ae, Kim, Ha-Young, Son, Dong-Won, Jeong, Jang-Hun, Lee, Byung-Woo, An, Hyo-Jin, and Lee, Hak Sung

Abstract

HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxiong, and Paeonia lactiflora, to improve impaired immune function. Considering the pharmacological benefits of its constituent herbal components, HemoHIM G is anticipated to have various health benefits; however, its toxicity has not been thoroughly evaluated. Here, we conducted a comprehensive study to assess the safety of HemoHIM G in terms of acute oral toxicity, 13-week repeat-dose toxicity, and genotoxicity. In the oral acute toxicity study, Sprague–Dawley rats were orally administered a single dose of HemoHIM G at 5000 mg/kg/day, the limit dose for the acute study. No abnormal findings or adverse effects were observed in this study, as confirmed by gross pathology. A 13-week repeated-dose toxicity study was conducted with HemoHIM G at doses of 1250, 2500, and 5000 mg/kg/day to examine the subchronic toxicity in both male and female rats after 28 days of dose-range finding study. No test substance-related clinical signs or mortality was observed at any of the tested doses. Gross pathology, hematology, blood chemistry, and histopathology were within normal ranges, further supporting the safety of HemoHIM G. Therefore, the NOAEL of HemoHIM G was considered to be at 5000 mg/kg/day for both sexes of rats. Bacterial reverse mutation tests, a chromosome aberration test in human peripheral blood lymphocytes, and a mouse micronuclei test were conducted to identify the potential genotoxicity of HemoHIM G. HemoHIM G is non-mutagenic and non-clastogenic. Collectively, these findings provide valuable evidence for the safe use of HemoHIM G as a functional food ingredient.

Published
2024
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18. Optimum conductive fabric sensor sites for evaluating the status of knee joint movements using bio-impedance

Author

Kim Jinkwon, Lee Chungkeun, Lee Byung Woo, and Lee Myoungho

Subjects
Medical technology, R855-855.5
Abstract

Abstract Background There have been many studies that utilize the bio-impedance measurement method to analyze the movements of the upper and lower limbs. A fixed electrical current flows into the limbs through four standard disposable electrodes in this method. The current flows in the muscles and blood vessels, which have relatively low resistivity levels in the human body. This method is used to measure bio-impedance changes following volume changes of muscles and blood vessels around a knee joint. The result of the bio-impedance changes is used to evaluate the movements. However, the method using the standard disposable electrodes has a restriction related to its low bio-impedance changes: the standard disposable electrodes are only able to measure bio-impedance from a limited part of a muscle. Moreover, it is impossible to use continuously, as the electrodes are designed to be disposable. This paper describes a conductive fabric sensor (CFS) using a bio-impedance measurement method and determines the optimum configuration of the sensor for estimating knee joint movements. Methods The upper side of subjects' lower limbs was divided into two areas and the lower side of subjects' lower limbs was divided into three areas. The spots were matched and 6 pairs were selected. Subjects were composed of 15 males (age: 30.7 ± 5.3, weight: 69.8 ± 4.2 kg, and height: 173.5 ± 2.8 cm) with no known problems with their knee joints. Bio-impedance changes according to knee joint flexion/extension assessments were calculated and compared with bio-impedance changes by an ankle joint flexion/extension test (SNR I) and a hip joint flexion/extension test (SNR II). Results The bio-impedance changes of the knee joint flexion/extension assessment were 35.4 ± 20.0 Ω on the (1, 5) pair. SNR I was 3.8 ± 8.4 and SNR II was 6.6 ± 7.9 on the (1, 5) pair. Conclusions The optimum conductive fabric sensor configuration for evaluating knee joint movements were represented by the (1, 5) pair.

Published
2011
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23. Application of alginate microbeads as a carrier of bone morphogenetic protein‐2 for bone regeneration.

Author

Lee, Yun Hwan, Lee, Byung‐Woo, Jung, Yun Chan, Yoon, Byung‐Il, Woo, Heung‐Myong, and Kang, Byung‐Jae

Abstract

Bone morphogenetic protein‐2 (BMP‐2) is commonly used to enhance bone regeneration. The potential of BMP‐2 for bone regeneration varies according to the concentration and release kinetics on the implanted site. Therefore, it is important to determine appropriate carriers of BMP‐2. However, no optimal delivery vehicles have been identified. In the present study, we used alginate microbeads as a delivery vehicle for BMP‐2. Alginate microbeads can be implanted onto the disease site through surgery or injection. The objective of this study was to evaluate that the osteoinductive properties of BMP‐2 are effective in alginate microbeads as a carrier. In this study, the release kinetics of BMP‐2 in alginate microbeads was evaluated using an enzyme‐linked immunosorbent assay. BMP‐2 released from alginate microbeads induced high alkaline phosphatase activity in canine adipose tissue‐derived mesenchymal stem cells. Injection of alginate microbeads with BMP‐2 into mouse subcutaneous tissue, as well as surgical implantation into the 5‐mm circular calvarial defects in rats, was conducted and the results showed extensive new bone formation. In conclusion, alginate microbeads can be utilized as an effective BMP‐2 delivery vehicle for use in orthopedic surgery and as an injectable vehicle for a minimally invasive therapy. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 286–294, 2019. [ABSTRACT FROM AUTHOR]

Published
2019
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