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309 results on '"Lee, Hak Sung"'

13. Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong,andPeaonia lactiflora

Author

Bak, Su-Bin, Choi, Hansol, Kim, Gyoung-Deuck, Kim, Ju Gyeong, Kwon, Da-Ae, Kim, Ha-Young, Son, Dong-Won, Jeong, Jang-Hun, Lee, Byung-Woo, An, Hyo-Jin, and Lee, Hak Sung

Abstract

HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxiong, and Paeonia lactiflora, to improve impaired immune function. Considering the pharmacological benefits of its constituent herbal components, HemoHIM G is anticipated to have various health benefits; however, its toxicity has not been thoroughly evaluated. Here, we conducted a comprehensive study to assess the safety of HemoHIM G in terms of acute oral toxicity, 13-week repeat-dose toxicity, and genotoxicity. In the oral acute toxicity study, Sprague–Dawley rats were orally administered a single dose of HemoHIM G at 5000 mg/kg/day, the limit dose for the acute study. No abnormal findings or adverse effects were observed in this study, as confirmed by gross pathology. A 13-week repeated-dose toxicity study was conducted with HemoHIM G at doses of 1250, 2500, and 5000 mg/kg/day to examine the subchronic toxicity in both male and female rats after 28 days of dose-range finding study. No test substance-related clinical signs or mortality was observed at any of the tested doses. Gross pathology, hematology, blood chemistry, and histopathology were within normal ranges, further supporting the safety of HemoHIM G. Therefore, the NOAEL of HemoHIM G was considered to be at 5000 mg/kg/day for both sexes of rats. Bacterial reverse mutation tests, a chromosome aberration test in human peripheral blood lymphocytes, and a mouse micronuclei test were conducted to identify the potential genotoxicity of HemoHIM G. HemoHIM G is non-mutagenic and non-clastogenic. Collectively, these findings provide valuable evidence for the safe use of HemoHIM G as a functional food ingredient.

Published
2024
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23. A Real Time Color Gamut Mapping Method Using a Neural Network

Author

Lee, Hak-Sung, Han, Dongil, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Wang, Lipo, editor, Chen, Ke, editor, and Ong, Yew Soon, editor

Published
2005
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42. Source identification and trends in concentrations of gaseous and fine particulate principal species in Seoul, South Korea

Author

Kang, Choong-Min, Kang, Byung-Wook, and Lee, Hak Sung

Subjects
Seoul, South Korea -- Environmental aspects, Environmental services industry, Environmental issues, Science and technology
Abstract

ABSTRACT Ambient measurements were made using two sets of annular denuder system during the four seasons (April 2001 to February 2002) and were then compared with the results during the [...]

Published
2006

45. Atmospheric concentrations of P[M.sub.2.5] trace elements in the Seoul urban area of South Korea

Author

Kang, Choong-Min, Sunwoo, Young, Lee, Hak Sung, Kang, Byung-Wook, and Lee, Sang-Kwun

Subjects
Refuse and refuse disposal -- Research, Environmental services industry, Environmental issues, Science and technology, Research
Abstract

ABSTRACT Fine particles (P[M.sub.2.5]) were collected during all four seasons, from April 2001 to February 2002, in Seoul, South Korea, using an annular denuder system. Elemental compositions of ambient P[M.sub.2.5] [...]

Published
2004

47. Effect of different WC particle shapes on laser-exposed microstructures during the directed energy deposition.

Author

Lee, Woo-Jin, Kim, Eun-Ah, Woo, Yeong-Jin, Park, Ihho, Yu, Ji-Hun, Ha, Taeho, Choi, Yoon Suk, and Lee, Hak-Sung

Subjects
HARD materials, TUNGSTEN carbide, LASER damage, LASER beams, MICROSTRUCTURE, METAL powders
Abstract

Tungsten carbide (WC) in Ni-based powders is a promising candidate for laser-based additive manufacturing because WC is an extremely hard material, whereas Ni is tough and weldable. However, WC particles that are directly exposed to a laser beam can be degraded or disintegrated into tungsten and carbon as a result of excess energy. In contrast, particles in the melt pool are relatively stable. In this study, the direct energy deposition method was used with irregular and spherical WC particles in metal powder. Irregular WC particles were found to be more directly affected by laser irradiation. To explain the effects of WC particle shapes on direct laser damage, a finitepoint calculation was performed to estimate the sinking time in the melt pool. The rectangular shape particles a longer sinking time depending on the rotation angle, whereas the spherical particles sank uniformly based on the difference in the effective area of resistance. [ABSTRACT FROM AUTHOR]

Published
2022
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