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217 results on '"Lee, Hyeon Ju"'

12. Remembering and Forgetting the Korean War in the Republic of Korea

Author

Lee, Hyeon Ju

Subjects
Research reports, Anthropology
Abstract

The Korean War had no official ending and has continued in a form of Cold War since 1953, the year the cease-fire agreement was signed, and yet, during the past five decades, it appears to have faded from South Korean memory. Anti-communism became a national ideology in post-war South Korea. For a country that was endeavoring to establish a national identity that differs from communist North Korea, the establishment of an anti-communist state was inevitable. However, the collapse of the Communist Bloc and a humanitarian crisis in North Korea in the 1990s led to attitudinal changes in the South Korean public toward North Korea. The forgetting and remembering of North Korea in conjunction with the memory of the Korean War has left the South Korean people ambivalent toward North Koreans. This paper explores social encounters between North and South Koreans in the late 2000s in Seoul that illustrate the uneasy interactions that stem from past anti-communist education as well as the subsequent erasure of social memory about North Korea as part of Korean culture. Keywords: history, memory, migration, North Korean refugees

Published
2023

20. Induction of ICAM1 in Brain Vessels is Implicated in an Early AD Pathogenesis by Modulating Neprilysin.

Author

Otgongerel, Degeree, Lee, Hyeon-Ju, and Jo, Sangmee Ahn

Abstract

Intercellular adhesion molecule 1 (ICAM1) is a vessel adhesion protein induced during brain vascular inflammation, which could be closely linked with the development of Alzheimer's disease (AD). This study investigated the effect of ICAM1 on amyloid-degrading enzymes (ADEs) in endothelial cells and their potential involvement in inflammation and AD progression. TNF-α treatment increased ICAM1 in human brain microvascular endothelial cells (HBMVECs) but decreased the neprilysin (NEP) protein level. Knock-down of ICAM1 using siRNA enhanced NEP, which increased the degradation of amyloid-β. In the brains of 4-month-old AD transgenic mice (APPswe/PSEN1dE9), there were significantly higher levels of ICAM1 expression and amyloid deposits but lower levels of NEP and insulin-degrading enzymes (IDE), demonstrating an inverse correlation of ICAM1 with NEP and IDE expression. Further studies demonstrated significantly increased GFAP protein levels in the brain, specifically localized near blood vessels, of both TNF-α-injected and 4-month-old AD transgenic mice. Taken together, the induction of ICAM1 in endothelial cells suppresses NEP expression, accelerating the accumulation of amyloid-β in blood vessels. It also enhances leukocyte adhesion to blood vessels stimulating the migration of leukocytes into the brain, subsequently triggering brain inflammation. [ABSTRACT FROM AUTHOR]

Published
2023
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23. DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation

Author

Lee, Hyeon Ju, Jung, Yu-Jin, Lee, Seungkoo, Kim, Jong-Il, and Han, Jeong A.

Subjects
p53, senescence, transformation, Membrane Proteins, Oncogenes, HSP40 Heat-Shock Proteins, Transfection, Mice, Cell Transformation, Neoplastic, Animals, Humans, DNAJB9, Tumor Suppressor Protein p53, Research Article, RAS, Cell Proliferation, Molecular Chaperones
Abstract

DNAJB9 is known to be a member of the molecular chaperone gene family, whose cellular function has not yet been fully characterized. Here, we investigated the cellular function of DNAJB9 under strong mitogenic signals. We found that DNAJB9 inhibits p53-dependent oncogene-induced senescence (OIS) and induces neoplastic transformation under oncogenic RAS activation in mouse primary fibroblasts. In addition, we observed that DNAJB9 interacts physically with p53 under oncogenic RAS activation and that the p53-interacting region of DNAJB9 is critical for the inhibition of p53-dependent OIS and induction of neoplastic transformation by DNAJB9. These results suggest that DNAJB9 induces cell transformation under strong mitogenic signals, which is attributable to the inhibition of p53-dependent OIS by physical interactions with p53. This study might contribute to our understanding of the cellular function of DNAJB9 and the molecular basis of cell transformation.

Published
2020

48. Novel short peptide tag from a bacterial toxin for versatile applications

Author

Lee, Tae Hee, primary, Kim, Kwang Soo, additional, Kim, Jin Hee, additional, Jeong, Jae-Ho, additional, Woo, Hye Ryun, additional, Park, So Ra, additional, Sohn, Myung-Ho, additional, Lee, Hyeon Ju, additional, Rhee, Joon Haeng, additional, Cha, Sun-Shin, additional, Hwang, Joo-Hee, additional, and Chung, Kyung Min, additional

Published
2020
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