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1,270 results on '"Lee, Je‐Hwan"'

5. The infusion of ex vivo, interleukin-15 and -21-activated donor NK cells after haploidentical HCT in high-risk AML and MDS patients—a randomized trial

Author

Lee, Kyoo-Hyung, Yoon, Suk Ran, Gong, Jeong-Ryeol, Choi, Eun-Ji, Kim, Hun Sik, Park, Chan-Jeoung, Yun, Sung-Cheol, Park, Soo-Yeon, Jung, Sol-Ji, Kim, Hanna, Lee, Soo Yun, Jung, Haiyoung, Byun, Jae-Eun, Kim, Mirang, Kim, Seon-Young, Kim, Jeong-Hwan, Lee, Je-Hwan, Lee, Jung-Hee, Choi, Yunsuk, Park, Han-Seung, Lee, Young-Shin, Kang, Young-Ah, Jeon, Mijin, Woo, Jimin, Kang, Hyeran, Baek, Seunghyun, Kim, Su Mi, Kim, Hoon-Min, Cho, Kwang-Hyun, and Choi, Inpyo

Published
2023
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6. Phase 3 trial of gilteritinib plus azacitidine vs azacitidine for newly diagnosed FLT3mut+ AML ineligible for intensive chemotherapy

Author

Wang, Eunice S., Montesinos, Pau, Minden, Mark D., Lee, Je-Hwan, Heuser, Michael, Naoe, Tomoki, Chou, Wen-Chien, Laribi, Kamel, Esteve, Jordi, Altman, Jessica K., Havelange, Violaine, Watson, Anne-Marie, Gambacorti-Passerini, Carlo, Patkowska, Elzbieta, Liu, Shufang, Wu, Ruishan, Philipose, Nisha, Hill, Jason E., Gill, Stanley C., Rich, Elizabeth Shima, and Tiu, Ramon V.

Published
2022
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8. Phase 3 randomized COMMODORE 2 trial: Crovalimab versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibition.

Author

Röth, Alexander, He, Guangsheng, Tong, Hongyan, Lin, Zenghua, Wang, Xiaoqin, Chai‐Adisaksopha, Chatree, Lee, Je‐Hwan, Brodsky, Andres, Hantaweepant, Chattree, Dumagay, Teresita E., Demichelis‐Gómez, Roberta, Rojnuckarin, Ponlapat, Sun, Jing, Höglund, Martin, Jang, Jun Ho, Gaya, Anna, Silva, Fernando, Obara, Naoshi, Kelly, Richard J., and Beveridge, Leigh

Published
2024
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11. Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆

Author

Yee, Karen, Papayannidis, Cristina, Vey, Norbert, Dickinson, Michael J., Kelly, Kevin R., Assouline, Sarit, Kasner, Margaret, Seiter, Karen, Drummond, Mark W., Yoon, Sung-Soo, Lee, Je-Hwan, Blotner, Steven, Jukofsky, Lori, Pierceall, William E., Zhi, Jianguo, Simon, Silke, Higgins, Brian, Nichols, Gwen, Monnet, Annabelle, Muehlbauer, Susanne, Ott, Marion, Chen, Lin-Chi, and Martinelli, Giovanni

Published
2021
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12. Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

Author

Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, null, null, Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, and null, null

Abstract

Purpose: Allogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with acute myeloid leukemia (AML) harboring an internal tandem duplication mutation of FLT3 (FLT3-ITD) AML. These patients are routinely treated with a FLT3 inhibitor after HCT, but there is limited evidence to support this. Accordingly, we conducted a randomized trial of post-HCT maintenance with the FLT3 inhibitor gilteritinib (ClinicalTrials.gov identifier: NCT02997202) to determine if all such patients benefit or if detection of measurable residual disease (MRD) could identify those who might benefit. Methods: Adults with FLT3-ITD AML in first remission underwent HCT and were randomly assigned to placebo or 120 mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival (RFS). Secondary end points included overall survival (OS) and the effect of MRD pre- and post-HCT on RFS and OS. Results: Three hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided P = .0518). However, 50.5% of participants had MRD detectable pre- or post-HCT, and, in a prespecified subgroup analysis, gilteritinib was beneficial in this population (HR, 0.515 [95% CI, 0.316 to 0.838]; P = .0065). Those without detectable MRD showed no benefit (HR, 1.213 [95% CI, 0.616 to 2.387]; P = .575). Conclusion: Although the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable FLT3-ITD MRD pre- or post-HCT who received gilteritinib treatment. To our knowledge, these data are among the first to support the effectiveness of MRD-based post-HCT therapy.

Published
2024

13. Clinical outcomes in patients with relapsed/refractory FLT3-mutated acute myeloid leukemia treated with gilteritinib who received prior midostaurin or sorafenib

Author

Perl, Alexander E., Hosono, Naoko, Montesinos, Pau, Podoltsev, Nikolai, Martinelli, Giovanni, Panoskaltsis, Nicki, Recher, Christian, Smith, Catherine C., Levis, Mark J., Strickland, Stephen, Röllig, Christoph, Groß-Langenhoff, Marco, Chou, Wen-Chien, Lee, Je-Hwan, Yokoyama, Hisayuki, Hasabou, Nahla, Lu, Qiaoyang, Tiu, Ramon V., and Altman, Jessica K.

Published
2022
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16. Interleukin-15 and -21-activated, donor-derived NK cell infusion after haploidentical HCT in high-risk AML and MDS—a cohort analysis

Author

Lee, Kyoo-Hyung, primary, Lee, Sewon, additional, Park, Young Hoon, additional, Mun, Yeung-Chul, additional, Choi, Eun-Ji, additional, Choi, Yunsuk, additional, Park, Han-Seung, additional, Lee, Jung-Hee, additional, Lee, Je-Hwan, additional, Park, Soo-Yeon, additional, Yoon, Suk Ran, additional, and Choi, Inpyo, additional

Published
2023
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19. Clinical Outcomes of Decitabine Treatment for Patients With Lower-Risk Myelodysplastic Syndrome on the Basis of the International Prognostic Scoring System

Author

Jung, Ki Sun, Kim, Yoo-Jin, Kim, Yeo-Kyeoung, Park, Sung Kyu, Kim, Hoon Gu, Kim, Soo Jeong, Park, Jinny, Choi, Chul Won, Do, Young Rok, Kim, Inho, Park, Seonyang, Mun, Yeung-Chul, Jeong, Seong Hyun, Kim, Min-Kyoung, Yi, Hyeon Gyu, Chang, Myung Hee, Kim, Su Youn, Lee, Je-Hwan, and Jang, Jun Ho

Published
2019
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22. Increased PD-1 expression of bone marrow T-cells in acute myeloid leukaemia patients after stem cell transplantation, and its association with overall survival.

Author

You, Eunkyoung, Park, Chan-Jeoung, Cho, Young-Uk, Jang, Seongsoo, Lee, Min Young, Kim, Hery, Koh, Kyung Nam, Im, Ho Joon, Choi, Eun-Ji, Lee, Je-Hwan, and Lee, Kyoo-Hyung

Subjects
BONE marrow, ACUTE myeloid leukemia, STEM cell transplantation, T cells, OVERALL survival, IMMUNE checkpoint proteins
Abstract

Background: Immune checkpoints are involved in mechanisms by which tumours escape from the host immune system. Our aim was to evaluate acute myeloid leukaemia (AML) patients to determine expression levels of checkpoint molecules according to diagnosis and treatments, and to identify optimal candidates for checkpoint blockade. Methods: Bone marrow (BM) samples were obtained from 279 AML patients at different disease status and from 23 controls. Flow cytometric analyses of PD-1 and PD-L1/PD-L2 expression were performed. Results: Programmed death-1 (PD-1) expression levels on CD8+ T-cells at AML diagnosis were increased compared to controls. PD-L1 and PD-L2 expression levels on leukaemic cells at diagnosis were significantly higher in secondary AML than in de novo AML. PD-1 levels on CD8+ and CD4+ T-cells after allo-SCT were significantly higher than those at diagnosis and after CTx. PD-1 expression on CD8+ T-cells increased in the acute GVHD group than in the non-GVHD group. The overall survival of patients with high PD-1 expression on CD8+ T-cells was significantly shorter than that of patients with low PD-1 expression. Conclusions: In conclusion, patients who underwent allo-SCT exhibited high PD-1 expression, suggesting that allo-SCT increases PD-1 expression on T-cells, and the patients with high PD-1 expression on CD8+ T-cells after allo-SCT showed the poor prognosis. For these patients, PD-1 blockade could be an immunotherapeutic strategy. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Increased PD-1 expression of bone marrow T-cells in acute myeloid leukaemia patients after stem cell transplantation, and its association with overall survival

Author

You, Eunkyoung, primary, Park, Chan-Jeoung, additional, Cho, Young-Uk, additional, Jang, Seongsoo, additional, Lee, Min Young, additional, Kim, Hery, additional, Koh, Kyung Nam, additional, Im, Ho Joon, additional, Choi, Eun-Ji, additional, Lee, Je-Hwan, additional, and Lee, Kyoo-Hyung, additional

Published
2023
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30. P1291: REAL-WORLD DATA OF LONG-TERM SURVIVALS IN PATIENTS WITH MANTLE CELL LYMPHOMA WHO UNDERWENT STEM CELL TRANSPLANTATION

Author

Won Baek, Dong, primary, Kim, Juhyung, additional, Lee, Je-Hwan, additional, Seong Park, Joon, additional, Hwan Yang, Deok, additional, Kim, Sung-Hyun, additional, Hoon Lee, Jae, additional, Sup Lee, Ho, additional, Kang, Ka-Won, additional, Ho Won, Jong, additional, Min Lee, Jung, additional, Ho Moon, Joon, additional, and Kyun Sohn, Sang, additional

Published
2023
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31. S181: THE PHASE III, RANDOMIZED COMMODORE 2 TRIAL: RESULTS FROM A MULTICENTER STUDY OF CROVALIMAB VS ECULIZUMAB IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) PATIENTS NAIVE TO COMPLEMENT INHIBITORS

Author

Röth, Alexander, primary, He, Guangsheng, additional, Brodsky, Andres, additional, Chai-Adisaksopha, Chatree Chatree, additional, Dumagay, Teresita, additional, Demichelis, Roberta, additional, Höglund, Martin, additional, Kelly, Richard, additional, Lee, Je-Hwan, additional, Nishimura, Jun-Ichi, additional, Obara, Naoshi, additional, Risitano, Antonio Maria, additional, Gaya, Anna, additional, Appius, Anita, additional, Gentile, Brittany, additional, Negricea, Raluca, additional, Zhang, Zilu, additional, Buatois, Simon, additional, and Han, Bing, additional

Published
2023
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34. Reduced-Intensity Conditioning with Busulfan, Fludarabine, and Antithymocyte Globulin for Hematopoietic Cell Transplantation from Unrelated or Haploidentical Family Donors in Patients with Acute Myeloid Leukemia in Remission

Author

Lee, Kyoo-Hyung, Lee, Je-Hwan, Lee, Jung-Hee, Kim, Dae-Young, Park, Han-Seung, Choi, Eun-Ji, Ko, Sun-Hye, Seol, Miee, Lee, Young-Shin, Kang, Young-A, Jeon, Mijin, Baek, Seunghyun, Kang, You-Lee, Kim, Sung-Han, Yun, Sung-Cheol, Kim, Hawk, Jo, Jae-Cheol, Choi, Yunsuk, Joo, Young-Don, and Lim, Sung-Nam

Published
2017
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38. Abstract CT026: A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced myeloid malignancies

Author

DiNardo, Courtney D., primary, Montesinos, Pau, additional, Benajiba, Lina, additional, Triguero, Ana, additional, Recher, Christian, additional, Schuh, Andre C., additional, Heiblig, Maël, additional, Bajel, Ashish, additional, Pigneux, Arnaud, additional, Alonso-Domiguez, Juan M., additional, Fathi, Amir T., additional, Grove, Carolyn, additional, Hou, Hsin-An, additional, Heuser, Michael, additional, Assouline, Sarit, additional, Fleming, Shaun, additional, Shin, Dong-Yeop, additional, Sweet, Kendra, additional, Odenike, Olatoyosi, additional, Altman, Jessica, additional, Ooi, Melissa Gaik Ming, additional, Zhentang, Lao, additional, Vey, Nobert, additional, Zeidner, Joshua, additional, Salhotra, Amandeep, additional, Wang, Eunice, additional, Schiller, Gary, additional, Porkka, Kimmo, additional, Zuckerman, Tsila, additional, Havelange, Violaine, additional, Jonas, Brian A., additional, Narayanan, Sujaatha, additional, Jang, Jun Ho, additional, Lee, Je-Hwan, additional, Szpurka, Anna M., additional, Heirich, Dana, additional, Chen, Hsiao Rong, additional, Hanft, Violet, additional, Zhao, Junjie, additional, Gueorguieva, Ivelina, additional, Zhang, Yin, additional, and Stein, Eytan M., additional

Published
2023
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39. Donor-Derived Natural Killer Cell Infusion after Human Leukocyte Antigen–Haploidentical Hematopoietic Cell Transplantation in Patients with Refractory Acute Leukemia

Author

Choi, Inpyo, Yoon, Suk Ran, Park, Soo-Yeon, Kim, Hanna, Jung, Sol-Ji, Kang, You-Lee, Lee, Je-Hwan, Lee, Jung-Hee, Kim, Dae-Young, Lee, Jae-Lyun, Park, Han-Seung, Choi, Eun-Ji, Lee, Young-Shin, Kang, Young-A., Jeon, Mijin, Seol, Miee, Baek, Seunghyun, Yun, Sung-Cheol, Kim, Hwa Jung, and Lee, Kyoo-Hyung

Published
2016
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41. Long-Term Efficacy and Safety of Eculizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria and High Disease Burden: Real-World Data From Korea

Author

Kim, Jin Seok, primary, Jang, Jun Ho, additional, Jo, Deog-Yeon, additional, Ahn, Seo-Yeon, additional, Yoon, Sung-Soo, additional, Lee, Je-Hwan, additional, Kim, Sung-Hyun, additional, Choi, Chul Won, additional, Shin, Ho-Jin, additional, Kim, Min-Kyoung, additional, Lee, Jae Hoon, additional, Mun, Yeung-Chul, additional, Kong, Jee Hyun, additional, Hyun, BokJin, additional, Nam, HyunSun, additional, Kim, Eunhye, additional, Kwak, Min Joo, additional, Won, Yong Kyun, additional, and Lee, Jong Wook, additional

Published
2023
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45. Safety and tolerability of eltrombopag versus placebo for treatment of thrombocytopenia in patients with advanced myelodysplastic syndromes or acute myeloid leukaemia: a multicentre, randomised, placebo-controlled, double-blind, phase 1/2 trial

Author

Platzbecker, Uwe, Wong, Raymond S M, Verma, Amit, Abboud, Camille, Araujo, Sergio, Chiou, Tzeon-Jye, Feigert, John, Yeh, Su-Peng, Götze, Katharina, Gorin, Norbert-Claude, Greenberg, Peter, Kambhampati, Suman, Kim, Yoo-Jin, Lee, Je-Hwan, Lyons, Roger, Ruggeri, Marco, Santini, Valeria, Cheng, Gregory, Jang, Jun Ho, Chen, Chien-Yuan, Johnson, Brendan, Bennett, John, Mannino, Frank, Kamel, Yasser Mostafa, Stone, Nicole, Dougherty, Souria, Chan, Geoffrey, and Giagounidis, Aristoteles

Published
2015
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46. Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia

Author

Kim, Dae-Young, Joo, Young-Don, Lim, Sung-Nam, Kim, Sung-Doo, Lee, Jung-Hee, Lee, Je-Hwan, Kim, Dong Hwan (Dennis), Kim, Kihyun, Jung, Chul Won, Kim, Inho, Yoon, Sung-Soo, Park, Seonyang, Ahn, Jae-Sook, Yang, Deok-Hwan, Lee, Je-Jung, Lee, Ho-Sup, Kim, Yang Soo, Mun, Yeung-Chul, Kim, Hawk, Park, Jae Hoo, Moon, Joon Ho, Sohn, Sang Kyun, Lee, Sang Min, Lee, Won Sik, Kim, Kyoung Ha, Won, Jong-Ho, Hyun, Myung Soo, Park, Jinny, Lee, Jae Hoon, Shin, Ho-Jin, Chung, Joo-Seop, Lee, Hyewon, Eom, Hyeon-Seok, Lee, Gyeong Won, Cho, Young-Uk, Jang, Seongsoo, Park, Chan-Jeoung, Chi, Hyun-Sook, and Lee, Kyoo-Hyung

Published
2015
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48. Salvage therapy for acute chemorefractory leukemia by allogeneic stem cell transplantation: the Korean experience

Author

Yoo, Shin Hye, Koh, Youngil, Kim, Dae-Young, Lee, Jung-Hee, Lee, Je-Hwan, Lee, Kyoo-Hyung, Yoon, Sung-Soo, Park, Seonyang, Park, Sung-Kyu, Hong, Dae-Sik, Yi, Hyeon Gyu, Kim, Chul-Soo, Jang, Ji Eun, Cheong, June-Won, Moon, Joonho, Min, Yoo Hong, Sohn, Sang Kyun, Kim, Inho, and for the Korean Society of Blood and Marrow Transplantation

Published
2017
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50. Role of Autologous or Allogeneic Stem Cell Transplantation in Patients with Peripheral T Cell Lymphomas (PTCLs)

Author

Baek, Dong Won, primary, Lee, Je-Hwan, additional, Im, Ho Joon, additional, Kim, Juhyung, additional, Park, Joon Seong, additional, Yang, Deok-Hwan, additional, Kim, Sung-Hyun, additional, Mun, Yeung-Chul, additional, Lee, Jae Hoon, additional, Lee, Ho Sup, additional, Kang, Ka-Won, additional, Lyu, Chuhl Joo, additional, Park, Seong Kyu, additional, Won, Jong Ho, additional, Jung, Chul Won, additional, Yoo, Keon Hee, additional, Yoon, Sung-Soo, additional, Bang, Soo-Mee, additional, Jo, Jae-Cheol, additional, Moon, Joon Ho, additional, and Sohn, Sang Kyun, additional

Published
2022
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