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203 results on '"Lee, Lilian"'

1. Geometric Support for Dark Matter by an Unaligned Einstein Ring in Abell 3827

Author

Chen, Mandy C., Broadhurst, Tom, Lim, Jeremy, Molnar, Sandor M., Diego, Jose M., Oguri, Masamune, and Lee, Lilian L.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

The non-detection of dark matter (DM) particles in increasingly stringent laboratory searches has encouraged alternative gravity theories where gravity is sourced only from visible matter. Here, we consider whether such theories can pass a two-dimensional test posed by gravitational lensing -- to reproduce a particularly detailed Einstein ring in the core of the galaxy cluster Abell 3827. We find that when we require the lensing mass distribution to strictly follow the shape (ellipticity and position angle) of the light distribution of cluster member galaxies, intracluster stars, and the X-ray emitting intracluster medium, we cannot reproduce the Einstein ring, despite allowing the mass-to-light ratios of these visible components to freely vary with radius to mimic alternative gravity theories. Alternatively, we show that the detailed features of the Einstein ring are accurately reproduced by allowing a smooth, freely oriented DM halo in the lens model, with relatively small contributions from the visible components at a level consistent with their observed brightnesses. This dominant DM component is constrained to have the same orientation as the light from the intracluster stars, indicating that the intracluster stars trace the gravitational potential of this component. The Einstein ring of Abell 3827 therefore presents a new challenge for alternative gravity theories: not only must such theories find agreement between the total lensing mass and visible mass, but they must also find agreement between the projected sky distribution of the lensing mass and that of the visible matter, a more stringent test than has hitherto been posed by lensing data., Comment: 20 pages, 7 figures, 8 tables. Accepted for publication in ApJ

Published
2020
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6. Importance of parental involvement in paediatric palliative care in Hong Kong: qualitative case study

Author

Wong, Frances Kam Yuet, primary, Ho, Jacqueline Mei Chi, additional, Lai, Tsz Chui, additional, Lee, Lilian Po Yee, additional, Ho, Eva Ka Yan, additional, Lee, Susanna Wai Yee, additional, Chan, Stephan C W, additional, Fung, Cheuk Wing, additional, Ho, Assunta Chi Hang, additional, Li, Chak-Ho, additional, Li, Chi Kong, additional, Chiu, Annie Ting Gee, additional, Tsui, Kwing Wan, additional, and Lam, Katherine Ka Wai, additional

Published
2023
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7. A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications.

Author

Phan, Duc TT, Wang, Xiaolin, Craver, Brianna M, Sobrino, Agua, Zhao, Da, Chen, Jerry C, Lee, Lilian YN, George, Steven C, Lee, Abraham P, and Hughes, Christopher CW

Subjects
Humans, Neoplasms, Experimental, Neovascularization, Pathologic, Antineoplastic Agents, Microfluidic Analytical Techniques, Tissue Array Analysis, Cell Culture Techniques, Equipment Design, Drug Evaluation, Preclinical, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Biotechnology, Cancer, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Chemical Sciences, Engineering, Analytical Chemistry
Abstract

There is a growing awareness that complex 3-dimensional (3D) organs are not well represented by monolayers of a single cell type - the standard format for many drug screens. To address this deficiency, and with the goal of improving screens so that drugs with good efficacy and low toxicity can be identified, microphysiological systems (MPS) are being developed that better capture the complexity of in vivo physiology. We have previously described an organ-on-a-chip platform that incorporates perfused microvessels, such that survival of the surrounding tissue is entirely dependent on delivery of nutrients through the vessels. Here we describe an arrayed version of the platform that incorporates multiple vascularized micro-organs (VMOs) on a 96-well plate. Each VMO is independently-addressable and flow through the micro-organ is driven by hydrostatic pressure. The platform is easy to use, requires no external pumps or valves, and is highly reproducible. As a proof-of-concept we have created arrayed vascularized micro tumors (VMTs) and used these in a blinded screen to assay a small library of compounds, including FDA-approved anti-cancer drugs, and successfully identified both anti-angiogenic and anti-tumor drugs. This 3D platform is suitable for efficacy/toxicity screening against multiple tissues in a more physiological environment than previously possible.

Published
2017

8. Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

Author

Richards, Laura M., Whitley, Owen K. N., MacLeod, Graham, Cavalli, Florence M. G., Coutinho, Fiona J., Jaramillo, Julia E., Svergun, Nataliia, Riverin, Mazdak, Croucher, Danielle C., Kushida, Michelle, Yu, Kenny, Guilhamon, Paul, Rastegar, Naghmeh, Ahmadi, Moloud, Bhatti, Jasmine K., Bozek, Danielle A., Li, Naijin, Lee, Lilian, Che, Clare, Luis, Erika, Park, Nicole I., Xu, Zhiyu, Ketela, Troy, Moore, Richard A., Marra, Marco A., Spears, Julian, Cusimano, Michael D., Das, Sunit, Bernstein, Mark, Haibe-Kains, Benjamin, Lupien, Mathieu, Luchman, H. Artee, Weiss, Samuel, Angers, Stephane, Dirks, Peter B., Bader, Gary D., and Pugh, Trevor J.

Published
2021
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9. Importance of parental involvement in paediatric palliative care in Hong Kong: qualitative case study.

Author

Kam Yuet Wong, Frances, Mei Chi Ho, Jacqueline, Tsz Chui Lai, Po Yee Lee, Lilian, Ka Yan Ho, Eva, Wai Yee, Susanna, Chan, Stephan C. W., Cheuk Wing Fung, Chi Hang Ho, Assunta, Chak Ho Li, Chi Kong Li, Ting Gee Chiu, Annie, Kwing Wan Tsui, and Ka Wai Lam, Katherine

Subjects
PEDIATRIC nursing, PARENTING, EPILEPSY, PALLIATIVE treatment, EPIDERMOLYSIS bullosa, FAMILY support, TRANSITION to adulthood
Published
2024
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10. PRMT5 inhibition disrupts splicing and stemness in glioblastoma

Author

Sachamitr, Patty, Ho, Jolene C., Ciamponi, Felipe E., Ba-Alawi, Wail, Coutinho, Fiona J., Guilhamon, Paul, Kushida, Michelle M., Cavalli, Florence M. G., Lee, Lilian, Rastegar, Naghmeh, Vu, Victoria, Sánchez-Osuna, María, Coulombe-Huntington, Jasmin, Kanshin, Evgeny, Whetstone, Heather, Durand, Mathieu, Thibault, Philippe, Hart, Kirsten, Mangos, Maria, Veyhl, Joseph, Chen, Wenjun, Tran, Nhat, Duong, Bang-Chi, Aman, Ahmed M., Che, Xinghui, Lan, Xiaoyang, Whitley, Owen, Zaslaver, Olga, Barsyte-Lovejoy, Dalia, Richards, Laura M., Restall, Ian, Caudy, Amy, Röst, Hannes L., Bonday, Zahid Quyoom, Bernstein, Mark, Das, Sunit, Cusimano, Michael D., Spears, Julian, Bader, Gary D., Pugh, Trevor J., Tyers, Mike, Lupien, Mathieu, Haibe-Kains, Benjamin, Artee Luchman, H., Weiss, Samuel, Massirer, Katlin B., Prinos, Panagiotis, Arrowsmith, Cheryl H., and Dirks, Peter B.

Published
2021
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13. Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and Wnt

Author

El-Sehemy, Ahmed, Selvadurai, Hayden, Ortin-Martinez, Arturo, Pokrajac, Neno, Mamatjan, Yasin, Tachibana, Nobuhiko, Rowland, Katherine, Lee, Lilian, Park, Nicole, Aldape, Kenneth, Dirks, Peter, and Wallace, Valerie A.

Subjects
R and D Systems, Neurophysiology, Cancer -- Development and progression, Software industry, Stem cells, Glioblastomas -- Development and progression, Health care industry
Abstract

Glioblastoma multiforme (GBM) contains a subpopulation of cells, GBM stem cells (GSCs), that maintain the bulk tumor and represent a key therapeutic target. Norrin is a Wnt ligand that binds Frizzled class receptor 4 (FZD4) to activate canonical Wnt signaling. Although Norrin, encoded by NDP, has a well-described role in vascular development, its function in human tumorigenesis is largely unexplored. Here, we show that NDP expression is enriched in neurological cancers, including GBM, and its levels positively correlated with survival in a GBM subtype defined by low expression of ASCL1, a proneural factor. We investigated the function of Norrin and FZD4 in GSCs and found that it mediated opposing tumor-suppressive and -promoting effects on [ASCL1.sup.lo] and [ASCL1.sup.hi] GSCs. Consistent with a potential tumor-suppressive effect of Norrin suggested by the tumor outcome data, we found that Norrin signaling through FZD4 inhibited growth in [ASCL1.sup.lo] GSCs. In contrast, in [ASCL1.sup.hi] GSCs Norrin promoted Notch signaling, independently of WNT, to promote tumor progression. Forced ASCL1 expression reversed the tumor-suppressive effects of Norrin in [ASCL1.sup.lo] GSCs. Our results identify Norrin as a modulator of human brain cancer progression and reveal an unanticipated Notch-mediated function of Norrin in regulating cancer stem cell biology. This study identifies an unanticipated role of Norrin in human brain cancer progression. In addition, we provide preclinical evidence suggesting Norrin and canonical Wnt signaling as potential therapeutic targets for GBM subtype-restricted cancer stem cells., Introduction Glioblastoma multiforme (GBM) is the most common malignant brain cancer in adults (1, 2). Consistent with its progressive nature, GBM remains significantly refractory to current therapeutic strategies (3, 4). [...]

Published
2020
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14. One-Month Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Zotarolimus-Eluting Stents in High-Bleeding-Risk Patients

Author

Kandzari, David E., Kirtane, Ajay J., Windecker, Stephan, Latib, Azeem, Kedhi, Elvin, Mehran, Roxana, Price, Matthew J., Abizaid, Alexandre, Simon, Daniel I., Worthley, Stephen G., Zaman, Azfar, Choi, James W., Caputo, Ronald, Kanitkar, Mihir, McLaurin, Brent, Potluri, Srinivasa, Smith, Timothy, Spriggs, Douglas, Tolleson, Thaddeus, Nazif, Tamim, Parke, Maria, Lee, Lilian C., Lung, Te-Hsin, and Stone, Gregg W.

Published
2020
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42. Importance of parental involvement in paediatric palliative care in Hong Kong: qualitative case study

Author

Wong, Frances Kam Yuet, Ho, Jacqueline Mei Chi, Lai, Tsz Chui, Lee, Lilian Po Yee, Ho, Eva Ka Yan, Lee, Susanna Wai Yee, Chan, Stephan C W, Fung, Cheuk Wing, Ho, Assunta Chi Hang, Li, Chak-Ho, Li, Chi Kong, Chiu, Annie Ting Gee, Tsui, Kwing Wan, and Lam, Katherine Ka Wai

Abstract

ObjectiveTo compare and contrast the perceived care needs of children with life-limiting conditions (CLLC) from the perspectives of the children, parents and healthcare providers.DesignA qualitative case study method using semistructured interviews was employed with a within-case and across-case analysis. Themes and subthemes emerging from the cases were compared and contrasted in the across-case analysis to explore the similarities and variations in participant perceptions.Setting/participantsThe setting was the paediatric departments of five regional hospitals in Hong Kong. Twenty-five sets of informants (CLLC–parent–healthcare provider) were recruited, with 65 individual interviews conducted.ResultsA total of 3784 units of analysis were identified, resulting in three themes with subthemes. ‘Living with the disease’ (55.8%) occupied the largest proportion, followed by ‘information and understanding about the disease’ (27.4%), and ‘care support and palliative care’ (16.8%). Healthcare provider support mainly focused on physical concerns. Family and social support were present, but carer stress created tension between couples. Doctors were the primary source of medical information, but the parents had to seek further information via the internet and support from patient groups. There was a perceived need for better coordination and collaboration of care. The palliative care approach coordinated by nurses was seen as helpful in addressing the care needs of the CLLC.ConclusionsThis original study identified the importance of palliative care with active engagement of parents which can address the service gap for CLLC.

Published
2024
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48. Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

Author

Lan, Xiaoyang, Jörg, David J., Cavalli, Florence M. G., Richards, Laura M., Nguyen, Long V., Vanner, Robert J., Guilhamon, Paul, Lee, Lilian, Kushida, Michelle M., Pellacani, Davide, Park, Nicole I., Coutinho, Fiona J., Whetstone, Heather, Selvadurai, Hayden J., Che, Clare, Luu, Betty, Carles, Annaick, Moksa, Michelle, Rastegar, Naghmeh, Head, Renee, Dolma, Sonam, Prinos, Panagiotis, Cusimano, Michael D., Das, Sunit, Bernstein, Mark, Arrowsmith, Cheryl H., Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Gallo, Marco, Lupien, Mathieu, Pugh, Trevor J., Taylor, Michael D., Hirst, Martin, Eaves, Connie J., Simons, Benjamin D., and Dirks, Peter B.

Published
2017
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49. Clinical outcomes according to lesion complexity in high bleeding risk patients treated with 1‐month dual antiplatelet therapy following PCI: Analysis from the Onyx ONE clear study

Author

Kandzari, David E., primary, Kirtane, Ajay J., additional, Mehran, Roxana, additional, Price, Matthew J., additional, Simon, Daniel I., additional, Latib, Azeem, additional, Kedhi, Elvin, additional, Abizaid, Alexandre, additional, Worthley, Stephen G., additional, Zaman, Azfar, additional, Hudec, Martin, additional, Stoler, Robert, additional, Choi, James W., additional, Kanitkar, Mihir, additional, Conradie, Andre, additional, Tam, Chor‐Cheung Frankie, additional, Walton, Antony, additional, Gruberg, Luis, additional, Ando, Kenji, additional, Lee, Lilian C., additional, Lung, Te‐Hsin, additional, Windecker, Stephan, additional, and Stone, Gregg W., additional

Published
2021
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