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2,447 results on '"Lee, Sang Heon"'

2. Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Author

Choi, Sungwoo, Kang, Ju-Gyeong, Tran, Yen T. H., Jeong, Sun-Hye, Park, Kun-Young, Shin, Hyemi, Kim, Young Hoon, Park, Myungsun, Nahmgoong, Hahn, Seol, Taejun, Jeon, Haeyon, Kim, Yeongmin, Park, Sanghee, Kim, Hee-joo, Kim, Min-Seob, Li, Xiaoxu, Bou Sleiman, Maroun, Lee, Eries, Choi, Jinhyuk, Eisenbarth, David, Lee, Sang Heon, Cho, Suhyeon, Moore, David D., Auwerx, Johan, Kim, Il-Young, Kim, Jae Bum, Park, Jong-Eun, Lim, Dae-Sik, and Suh, Jae Myoung

Published
2024
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4. NEAR: Named Entity and Attribute Recognition of clinical concepts

Author

Nath, Namrata, Lee, Sang-Heon, and Lee, Ivan

Subjects
Computer Science - Computation and Language, 68U15 (primary)
Abstract

Named Entity Recognition (NER) or the extraction of concepts from clinical text is the task of identifying entities in text and slotting them into categories such as problems, treatments, tests, clinical departments, occurrences (such as admission and discharge) and others. NER forms a critical component of processing and leveraging unstructured data from Electronic Health Records (EHR). While identifying the spans and categories of concepts is itself a challenging task, these entities could also have attributes such as negation that pivot their meanings implied to the consumers of the named entities. There has been little research dedicated to identifying the entities and their qualifying attributes together. This research hopes to contribute to the area of detecting entities and their corresponding attributes by modelling the NER task as a supervised, multi-label tagging problem with each of the attributes assigned tagging sequence labels. In this paper, we propose 3 architectures to achieve this multi-label entity tagging: BiLSTM n-CRF, BiLSTM-CRF-Smax-TF and BiLSTM n-CRF-TF. We evaluate these methods on the 2010 i2b2/VA and the i2b2 2012 shared task datasets. Our different models obtain best NER F1 scores of 0. 894 and 0.808 on the i2b2 2010/VA and i2b2 2012 respectively. The highest span based micro-averaged F1 polarity scores obtained were 0.832 and 0.836 on the i2b2 2010/VA and i2b2 2012 datasets respectively, and the highest macro-averaged F1 polarity scores obtained were 0.924 and 0.888 respectively. The modality studies conducted on i2b2 2012 dataset revealed high scores of 0.818 and 0.501 for span based micro-averaged F1 and macro-averaged F1 respectively., Comment: 11 pages, 7 figures, 9 tables

Published
2022
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15. Ultra‐Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks

Author

Liu, Ren, Lee, Jihwan, Tchoe, Youngbin, Pre, Deborah, Bourhis, Andrew M, D'Antonio‐Chronowska, Agnieszka, Robin, Gaelle, Lee, Sang Heon, Ro, Yun Goo, Vatsyayan, Ritwik, Tonsfeldt, Karen J, Hossain, Lorraine A, Phipps, M Lisa, Yoo, Jinkyoung, Nogan, John, Martinez, Jennifer S, Frazer, Kelly A, Bang, Anne G, and Dayeh, Shadi A

Subjects
Engineering, Biomedical Engineering, cardiomyocytes, culture, intracellular, nanowires, neurons, tissues, cardiomyocyte, nanowire, neuron, tissue, Physical Sciences, Chemical Sciences, Materials, Chemical sciences, Physical sciences
Abstract

We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms.

Published
2022

16. Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks

Author

Liu, Ren, Lee, Jihwan, Tchoe, Youngbin, Pre, Deborah, Bourhis, Andrew M., D'Antonio-Chronowska, Agnieszka, Robin, Gaelle, Lee, Sang Heon, Ro, Yun Goo, Vatsyayan, Ritwik, Tonsfeldt, Karen J., Hossain, Lorraine A., Phipps, M. Lisa, Yoo, Jinkyoung, Nogan, John, Martinez, Jennifer S., Frazer, Kelly A., Bang, Anne G., and Dayeh, Shadi A.

Subjects
Condensed Matter - Materials Science, Physics - Biological Physics, Physics - Medical Physics, Quantitative Biology - Cell Behavior, Quantitative Biology - Neurons and Cognition
Abstract

Intracellular access with high spatiotemporal resolution can enhance our understanding of how neurons or cardiomyocytes regulate and orchestrate network activity, and how this activity can be affected with pharmacology or other interventional modalities. Nanoscale devices often employ electroporation to transiently permeate the cell membrane and record intracellular potentials, which tend to decrease rapidly to extracellular potential amplitudes with time. Here, we report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. We report large action potential amplitudes that are indicative of intracellular access from 3D tissue-like networks of neurons and cardiomyocytes across recording days and that do not decrease to extracellular amplitudes for the duration of the recording of several minutes. Our findings are validated with cross-sectional microscopy, pharmacology, and electrical interventions. Our experiments and simulations demonstrate that individual electrical addressability of nanowires is necessary for high-fidelity intracellular electrophysiological recordings. This study advances our understanding of and control over high-quality multi-channel intracellular recordings, and paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms., Comment: Main manuscript: 33 pages, 4 figures, Supporting information: 43 pages, 27 figures, Submitted to Advanced Materials

Published
2021

20. Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Author

Park, Anna, Kim, Kwang-eun, Park, Isaac, Lee, Sang Heon, Park, Kun-Young, Jung, Minkyo, Li, Xiaoxu, Sleiman, Maroun Bou, Lee, Su Jeong, Kim, Dae-Soo, Kim, Jaehoon, Lim, Dae-Sik, Woo, Eui-Jeon, Lee, Eun Woo, Han, Baek Soo, Oh, Kyoung-Jin, Lee, Sang Chul, Auwerx, Johan, Mun, Ji Young, Rhee, Hyun-Woo, Kim, Won Kon, Bae, Kwang-Hee, and Suh, Jae Myoung

Published
2023
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43. Video Face Recognition with Audio-Visual Aggregation Network

Author

Li, Qinbo, Wan, Qing, Lee, Sang-Heon, Choe, Yoonsuck, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Mantoro, Teddy, editor, Lee, Minho, editor, Ayu, Media Anugerah, editor, Wong, Kok Wai, editor, and Hidayanto, Achmad Nizar, editor

Published
2021
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45. Microscale dynamics of electrophysiological markers of epilepsy

Author

Yang, Jimmy C., Paulk, Angelique C., Salami, Pariya, Lee, Sang Heon, Ganji, Mehran, Soper, Daniel J., Cleary, Daniel, Simon, Mirela, Maus, Douglas, Lee, Jong Woo, Nahed, Brian V., Jones, Pamela S., Cahill, Daniel P., Cosgrove, Garth Rees, Chu, Catherine J., Williams, Ziv, Halgren, Eric, Dayeh, Shadi, and Cash, Sydney S.

Published
2021
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