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2,443 results on '"Lee, Sung-Ho"'

1. fMRI data acquisition and analysis for task-free, anesthetized rats

Author

Vrooman, Roël M., van den Berg, Monica, Desrosiers-Gregoire, Gabriel, van Engelenburg, Wessel A., Galteau, Marie E., Lee, Sung-Ho, Veltien, Andor, Barrière, David A., Cash, Diana, Chakravarty, M. Mallar, Devenyi, Gabriel A., Gozzi, Alessandro, Gröhn, Olli, Hess, Andreas, Homberg, Judith R., Jelescu, Ileana O., Keliris, Georgios A., Scheenen, Tom, Shih, Yen-Yu Ian, Verhoye, Marleen, Wary, Claire, Zwiers, Marcel, and Grandjean, Joanes

Published
2025
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8. Equivariant graph neural network interatomic potential for Green-Kubo thermal conductivity in phase change materials

Author

Lee, Sung-Ho, Li, Jing, Olevano, Valerio, and Sklénard, Benoit

Subjects
Condensed Matter - Materials Science, Condensed Matter - Disordered Systems and Neural Networks, Physics - Computational Physics
Abstract

Thermal conductivity is a fundamental material property that plays an essential role in technology, but its accurate evaluation presents a challenge for theory. In this work, we demonstrate the application of $E(3)$-equivariant neutral network interatomic potentials within Green-Kubo formalism to determine the lattice thermal conductivity in amorphous and crystalline materials. We apply this method to study the thermal conductivity of germanium telluride (GeTe) as a prototypical phase change material. A single deep learning interatomic potential is able to describe the phase transitions between the amorphous, rhombohedral and cubic phases, with critical temperatures in good agreement with experiments. Furthermore, this approach accurately captures the pronounced anharmonicity that is present in GeTe, enabling precise calculations of the thermal conductivity. In contrast, the Boltzmann transport equation including only three-phonon processes tends to overestimate the thermal conductivity by approximately a factor of 2 in the crystalline phases.

Published
2023

9. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice

Author

Heo, Mi Jeong, Suh, Ji Ho, Lee, Sung Ho, Poulsen, Kyle L, An, Yu A, Moorthy, Bhagavatula, Hartig, Sean M, Moore, David D, and Kim, Kang Ho

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Digestive Diseases, Biotechnology, Liver Disease, Chronic Liver Disease and Cirrhosis, Underpinning research, 2.1 Biological and endogenous factors, Aetiology, 1.1 Normal biological development and functioning, Mice, Animals, Reactive Oxygen Species, Receptors, Aryl Hydrocarbon, Ligands, Mitochondria, Liver, Mice, Knockout, Homeostasis, Mitophagy, Autophagy, Reactive oxygen species, BNIP3, Kynurenine, Physiology, Biochemistry and cell biology
Abstract

ObjectiveMitophagy removes damaged mitochondria to maintain cellular homeostasis. Aryl hydrocarbon receptor (AhR) expression in the liver plays a crucial role in supporting normal liver functions, but its impact on mitochondrial function is unclear. Here, we identified a new role of AhR in the regulation of mitophagy to control hepatic energy homeostasis.MethodsIn this study, we utilized primary hepatocytes from AhR knockout (KO) mice and AhR knockdown AML12 hepatocytes. An endogenous AhR ligand, kynurenine (Kyn), was used to activate AhR in AML12 hepatocytes. Mitochondrial function and mitophagy process were comprehensively assessed by MitoSOX and mt-Keima fluorescence imaging, Seahorse XF-based oxygen consumption rate measurement, and Mitoplate S-1 mitochondrial substrate utilization analysis.ResultsTranscriptomic analysis indicated that mitochondria-related gene sets were dysregulated in AhR KO liver. In both primary mouse hepatocytes and AML12 hepatocyte cell lines, AhR inhibition strongly suppressed mitochondrial respiration rate and substrate utilization. AhR inhibition also blunted the fasting response of several essential autophagy genes and the mitophagy process. We further identified BCL2 interacting protein 3 (BNIP3), a mitophagy receptor that senses nutrient stress, as an AhR target gene. AhR is directly recruited to the Bnip3 genomic locus, and Bnip3 transcription was enhanced by AhR endogenous ligand treatment in wild-type liver and abolished entirely in AhR KO liver. Mechanistically, overexpression of Bnip3 in AhR knockdown cells mitigated the production of mitochondrial reactive oxygen species (ROS) and restored functional mitophagy.ConclusionsAhR regulation of the mitophagy receptor BNIP3 coordinates hepatic mitochondrial function. Loss of AhR induces mitochondrial ROS production and impairs mitochondrial respiration. These findings provide new insight into how endogenous AhR governs hepatic mitochondrial homeostasis.

Published
2023

30. A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E. M., Guo, Chao C. G., Henckens, Marloes J. A. G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung-Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M. P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A. B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T. B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J. G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J. P. C., Blezer, Erwin L. A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai-Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean-Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen-Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W. J., Shemesh, Noam, Shih, Yen-Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A. F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, and Hess, Andreas

Published
2023
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31. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation

Author

Lee, Sung Ho, Choi, Jong Min, Jung, Sung Yun, Cox, Aaron R, Hartig, Sean M, Moore, David D, and Kim, Kang Ho

Subjects
Biochemistry and Cell Biology, Biological Sciences, Diabetes, Obesity, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Liver Disease, Genetics, Nutrition, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Oral and gastrointestinal, 3T3-L1 Cells, Adipogenesis, Animals, Bile Acids and Salts, Cattle, Fibroblasts, Lipogenesis, Liver, Male, Mice, Mice, Inbred C57BL, Orosomucoid, Protein Isoforms, Proteomics, Bile acid, Hepatokine, Medicinal and Biomolecular Chemistry, Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry
Abstract

Bile acids have recently emerged as key metabolic hormones with beneficial impacts in multiple metabolic diseases. We previously discovered that hepatic bile acid overload distally modulates glucose and fatty acid metabolism in adipose tissues to exert anti-obesity effects. However, the detailed mechanisms that explain the salutary effects of serum bile acid elevation remain unclear. Here, proteomic profiling identified a new hepatokine, Orosomucoid (ORM) that governs liver-adipose tissue crosstalk. Hepatic ORMs were highly induced by both genetic and dietary bile acid overload. To address the direct metabolic effects of ORM, purified ORM proteins were administered during adipogenic differentiation of 3T3-L1 cells and mouse stromal vascular fibroblasts. ORM suppressed adipocyte differentiation and strongly inhibited gene expression of adipogenic transcription factors such as C/EBPβ, KLF5, C/EBPα, and PPARγ. Taken together, our data clearly suggest that bile acid-induced ORM secretion from the liver blocks adipocyte differentiation, potentially linked to anti-obesity effect of bile acids.

Published
2021

43. Intra-individual comparison of long-term outcomes between combined and indirect bypass surgery in adult moyamoya disease.

Author

Chung, Yuwhan, Kim, Jeong Eun, Kang, Hyun-Seung, Kim, Tae Young, Paeng, Jin Chul, Cho, Won-Sang, Lee, Sung Ho, Ha, Eun Jin, and Kim, Kangmin

Subjects
MOYAMOYA disease, CEREBRAL circulation, CEREBRAL infarction, STROKE, ANGIOGRAPHY
Abstract

Purpose: Bypass surgery is regarded as the standard treatment option for symptomatic and hemodynamically unstable moyamoya disease (MMD). However, there is ongoing debate about the most effective type of bypass surgery. We aimed to analyze the long-term outcomes of combined and indirect bypasses for MMD patients through intra-individual comparisons. Methods: Of the 896 patients who underwent 1084 bypass surgeries between 2007 and 2021, 24 patients with MMD who underwent combined bypass on one side and indirect bypass on the other side were ultimately enrolled in this study. Clinical, angiographic and hemodynamic outcomes were retrospectively evaluated. Results: Three asymptomatic strokes (12.5%) occurred within 30 postoperative days in each group. Postoperative strokes after 30 days occurred in 3 patients (12.5%) with 3 hemorrhagic events and 1 cerebral infarction, only in indirect bypass, while no stroke occurred in hemispheres treated with combined bypass. The revascularization area relative to supratentorial area was significantly greater in combined bypass than in indirect bypass, both in short-term and long-term periods (64.9% versus 43.9% in short-term and 75.7% versus 54.9% in long-term; P <.001, respectively). Hemodynamic outcomes showed significantly greater increases in acetazolamide-challenged cerebral blood flow (CBFacz) during short-term follow-up (P =.04) and in both basal CBF (CBFbas) and CBFacz during long-term follow-up (P =.014 and P =.009, respectively) in combined bypass than in indirect bypass. Conclusion: Combined bypass may be a more effective treatment option for MMD based on its higher revascularization area and favorable hemodynamic results compared to indirect bypass in the same patient. [ABSTRACT FROM AUTHOR]

Published
2025
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46. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling

Author

Jung, Youn-Sang, Jun, Sohee, Kim, Moon Jong, Lee, Sung Ho, Suh, Han Na, Lien, Esther M, Jung, Hae-Yun, Lee, Sunhye, Zhang, Jie, Yang, Jung-In, Ji, Hong, Wu, Ji Yuan, Wang, Wenqi, Miller, Rachel K, Chen, Junjie, McCrea, Pierre D, Kopetz, Scott, and Park, Jae-Il

Subjects
Biochemistry and Cell Biology, Biological Sciences, Colo-Rectal Cancer, Digestive Diseases, Cancer, 2.1 Biological and endogenous factors, Adenomatous Polyposis Coli Protein, Animals, Cell Transformation, Neoplastic, Colorectal Neoplasms, HCT116 Cells, HT29 Cells, HeLa Cells, Humans, Hydrogen-Ion Concentration, Intestines, Membrane Proteins, Mice, Inbred BALB C, Mice, Knockout, Mice, Nude, Protein Binding, Transplantation, Heterologous, Vacuolar Proton-Translocating ATPases, Wnt Signaling Pathway, Hela Cells, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

Vesicular acidification and trafficking are associated with various cellular processes. However, their pathologic relevance to cancer remains elusive. We identified transmembrane protein 9 (TMEM9) as a vesicular acidification regulator. TMEM9 is highly upregulated in colorectal cancer. Proteomic and biochemical analyses show that TMEM9 binds to and facilitates assembly of vacuolar-ATPase (v-ATPase), a vacuolar proton pump, resulting in enhanced vesicular acidification and trafficking. TMEM9-v-ATPase hyperactivates Wnt/β-catenin signalling via lysosomal degradation of adenomatous polyposis coli (APC). Moreover, TMEM9 transactivated by β-catenin functions as a positive feedback regulator of Wnt signalling in colorectal cancer. Genetic ablation of TMEM9 inhibits colorectal cancer cell proliferation in vitro, ex vivo and in vivo mouse models. Moreover, administration of v-ATPase inhibitors suppresses intestinal tumorigenesis of APC mouse models and human patient-derived xenografts. Our results reveal the unexpected roles of TMEM9-controlled vesicular acidification in hyperactivating Wnt/β-catenin signalling through APC degradation, and propose the blockade of TMEM9-v-ATPase as a viable option for colorectal cancer treatment.

Published
2018

50. Clinical characteristics of apixaban prescription in AF patients with single dose-reduction criterion: the ASPIRE (efficAcy and safety of aPixaban in rEal-world practice in Korean frail patients with atrial fibrillation) study

Author

Choi, JungMin, primary, Lee, So-Ryoung, additional, Kwon, Soonil, additional, Ahn, Hyo-Jeong, additional, Lee, Kyung-Yeon, additional, Park, Jong-Sung, additional, Choi, Jong-Il, additional, Lee, Sung Ho, additional, Heo, Jung Ho, additional, Oh, Il-Young, additional, On, Young Keun, additional, Yu, Hee Tae, additional, Lee, Kwang-No, additional, Kim, Nam-Ho, additional, Park, Hyung Wook, additional, Lee, Ki Hong, additional, Shin, Seung Yong, additional, Oh, Seil, additional, Lip, Gregory Y. H., additional, Han, Seongwook, additional, and Choi, Eue-Keun, additional

Published
2024
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