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2. Author Correction: Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

Author

van der Stegen, Sjoukje J. C., Lindenbergh, Pieter L., Petrovic, Roseanna M., Xie, Hongyao, Diop, Mame P., Alexeeva, Vera, Shi, Yuzhe, Mansilla-Soto, Jorge, Hamieh, Mohamad, Eyquem, Justin, Cabriolu, Annalisa, Wang, Xiuyan, Abujarour, Ramzey, Lee, Tom, Clarke, Raedun, Valamehr, Bahram, Themeli, Maria, Riviere, Isabelle, and Sadelain, Michel

Published
2024
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4. Compositionally Complex Perovskite Oxides as a New Class of Li-Ion Solid Electrolytes

Author

Ko, Shu-Ting, Lee, Tom, Qi, Ji, Zhang, Dawei, Peng, Wei-Tao, Wang, Xin, Tsai, Wei-Che, Sun, Shikai, Wang, Zhaokun, Bowman, William J., Ong, Shyue Ping, Pan, Xiaoqing, and Luo, Jian

Subjects
Condensed Matter - Materials Science
Abstract

Compositionally complex ceramics (CCCs), including high-entropy ceramics (HECs) as a subclass, offer new opportunities of materials discovery beyond the traditional methodology of searching new stoichiometric compounds. Herein, we establish new strategies of tailoring CCCs via a seamless combination of (1) non-equimolar compositional designs and (2) controlling microstructures and interfaces. Using oxide solid electrolytes for all-solid-state batteries as an exemplar, we validate these new strategies via discovering a new class of compositionally complex perovskite oxides (CCPOs) to show the possibility of improving ionic conductivities beyond the limit of conventional doping. As an example (amongst the 28 CCPOs examined), we demonstrate that the ionic conductivity can be improved by >60% in (Li0.375Sr0.4375)(Ta0.375Nb0.375Zr0.125Hf0.125)O3-{\delta}, in comparison with the state-of-art (Li0.375Sr0.4375)(Ta0.75Zr0.25)O3-{\delta} (LSTZ) baseline, via maintaining comparable electrochemical stability. Furthermore, the ionic conductivity can be improved by another >70% via grain boundary (GB) engineering, achieving >270% of the LSTZ baseline. This work suggests transformative new strategies for designing and tailoring HECs and CCCs, thereby opening a new window for discovering materials for energy storage and many other applications.

Published
2022

5. Atomic-scale origin of the low grain-boundary resistance in perovskite solid electrolyte Li0.375Sr0.4375Ta0.75Zr0.25O3.

Author

Lee, Tom, Qi, Ji, Gadre, Chaitanya A, Huyan, Huaixun, Ko, Shu-Ting, Zuo, Yunxing, Du, Chaojie, Li, Jie, Aoki, Toshihiro, Wu, Ruqian, Luo, Jian, Ong, Shyue Ping, and Pan, Xiaoqing

Subjects
Affordable and Clean Energy
Abstract

Oxide solid electrolytes (OSEs) have the potential to achieve improved safety and energy density for lithium-ion batteries, but their high grain-boundary (GB) resistance generally is a bottleneck. In the well-studied perovskite oxide solid electrolyte, Li3xLa2/3-xTiO3 (LLTO), the ionic conductivity of grain boundaries is about three orders of magnitude lower than that of the bulk. In contrast, the related Li0.375Sr0.4375Ta0.75Zr0.25O3 (LSTZ0.75) perovskite exhibits low grain boundary resistance for reasons yet unknown. Here, we use aberration-corrected scanning transmission electron microscopy and spectroscopy, along with an active learning moment tensor potential, to reveal the atomic scale structure and composition of LSTZ0.75 grain boundaries. Vibrational electron energy loss spectroscopy is applied for the first time to reveal atomically resolved vibrations at grain boundaries of LSTZ0.75 and to characterize the otherwise unmeasurable Li distribution therein. We find that Li depletion, which is a major reason for the low grain boundary ionic conductivity of LLTO, is absent for the grain boundaries of LSTZ0.75. Instead, the low grain boundary resistivity of LSTZ0.75 is attributed to the formation of a nanoscale defective cubic perovskite interfacial structure that contained abundant vacancies. Our study provides new insights into the atomic scale mechanisms of low grain boundary resistivity.

Published
2023

8. Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells.

Author

van der Stegen, Sjoukje, Lindenbergh, Pieter, Petrovic, Roseanna, Xie, Hongyao, Diop, Mame, Alexeeva, Vera, Shi, Yuzhe, Mansilla-Soto, Jorge, Hamieh, Mohamad, Eyquem, Justin, Cabriolu, Annalisa, Wang, Xiuyan, Abujarour, Ramzey, Lee, Tom, Clarke, Raedun, Valamehr, Bahram, Themeli, Maria, Riviere, Isabelle, and Sadelain, Michel

Subjects
Mice, Animals, Humans, T-Lymphocytes, Induced Pluripotent Stem Cells, Receptors, Antigen, T-Cell, CD8 Antigens, Receptors, Chimeric Antigen
Abstract

The production of autologous T cells expressing a chimaeric antigen receptor (CAR) is time-consuming, costly and occasionally unsuccessful. T-cell-derived induced pluripotent stem cells (TiPS) are a promising source for the generation of off-the-shelf CAR T cells, but the in vitro differentiation of TiPS often yields T cells with suboptimal features. Here we show that the premature expression of the T-cell receptor (TCR) or a constitutively expressed CAR in TiPS promotes the acquisition of an innate phenotype, which can be averted by disabling the TCR and relying on the CAR to drive differentiation. Delaying CAR expression and calibrating its signalling strength in TiPS enabled the generation of human TCR- CD8αβ+ CAR T cells that perform similarly to CD8αβ+ CAR T cells from peripheral blood, achieving effective tumour control on systemic administration in a mouse model of leukaemia and without causing graft-versus-host disease. Driving T-cell maturation in TiPS in the absence of a TCR by taking advantage of a CAR may facilitate the large-scale development of potent allogeneic CD8αβ+ T cells for a broad range of immunotherapies.

Published
2022

9. Atomic-scale origin of the low grain-boundary resistance in perovskite solid electrolytes

Author

Lee, Tom, Qi, Ji, Gadre, Chaitanya A., Huyan, Huaixun, Ko, Shu-Ting, Zuo, Yunxing, Du, Chaojie, Li, Jie, Aoki, Toshihiro, Stippich, Caden John, Wu, Ruqian, Luo, Jian, Ong, Shyue Ping, and Pan, Xiaoqing

Subjects
Condensed Matter - Materials Science
Abstract

Oxide solid electrolytes (OSEs) have the potential to achieve improved safety and energy density for lithium-ion batteries, but their high grain-boundary (GB) resistance is a general bottleneck. In the most well studied perovskite OSE, Li3xLa2/3-xTiO3 (LLTO), the ionic conductivity of GBs is about three orders of magnitude lower than that of the bulk. In contrast, the related Li0.375Sr0.4375Ta0.75Zr0.25O3 (LSTZ0.75) perovskite exhibits low GB resistance for reasons yet unknown. Here, we used aberration-corrected scanning transmission electron microscopy and spectroscopy, along with an active learning moment tensor potential, to reveal the atomic scale structure and composition of LSTZ0.75 GBs. Vibrational electron energy loss spectroscopy is applied for the first time to characterize the otherwise unmeasurable Li distribution in GBs of LSTZ0.75. We found that Li depletion, which is a major reason for the low GB ionic conductivity of LLTO, is absent for the GBs of LSTZ0.75. Instead, the low GB resistivity of LSTZ0.75 is attributed to the formation of a unique defective cubic perovskite interfacial structure that contained abundant vacancies. Our study provides insights into the atomic scale mechanisms of low GB resistivity and sheds light on possible paths for designing OSEs with high total ionic conductivity.

Published
2022
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10. Polyp detection with colonoscopy assisted by the GI Genius artificial intelligence endoscopy module compared with standard colonoscopy in routine colonoscopy practice (COLO-DETECT): a multicentre, open-label, parallel-arm, pragmatic randomised controlled trial

Author

Cripps, Neil, Greenaway, John, Higham, Andrew, Jacob, John, Murugananthan, Aravinth, Nylander, David, Patel, Panna, Singh, Salil, Verma, Ajay M, Seager, Alexander, Sharp, Linda, Neilson, Laura J, Brand, Andrew, Hampton, James S, Lee, Tom J W, Evans, Rachel, Vale, Luke, Whelpton, John, Bestwick, Nathania, and Rees, Colin J

Published
2024
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11. Metasurface wavefront control for high-performance user-natural augmented reality waveguide glasses

Author

Boo, Hyunpil, Lee, Yoo Seung, Yang, Hangbo, Matthews, Brian, Lee, Tom G, and Wong, Chee Wei

Subjects
Bioengineering
Abstract

Augmented reality (AR) devices, as smart glasses, enable users to see both the real world and virtual images simultaneously, contributing to an immersive experience in interactions and visualization. Recently, to reduce the size and weight of smart glasses, waveguides incorporating holographic optical elements in the form of advanced grating structures have been utilized to provide light-weight solutions instead of bulky helmet-type headsets. However current waveguide displays often have limited display resolution, efficiency and field-of-view, with complex multi-step fabrication processes of lower yield. In addition, current AR displays often have vergence-accommodation conflict in the augmented and virtual images, resulting in focusing-visual fatigue and eye strain. Here we report metasurface optical elements designed and experimentally implemented as a platform solution to overcome these limitations. Through careful dispersion control in the excited propagation and diffraction modes, we design and implement our high-resolution full-color prototype, via the combination of analytical-numerical simulations, nanofabrication and device measurements. With the metasurface control of the light propagation, our prototype device achieves a 1080-pixel resolution, a field-of-view more than 40°, an overall input-output efficiency more than 1%, and addresses the vergence-accommodation conflict through our focal-free implementation. Furthermore, our AR waveguide is achieved in a single metasurface-waveguide layer, aiding the scalability and process yield control.

Published
2022

14. Analyses of residual accelerations for TianQin based on the global MHD simulation

Author

Su, Wei, Wang, Yan, Zhou, Ze-Bing, Bai, Yan-Zheng, Guo, Yang, Zhou, Chen, Lee, Tom, Wang, Ming, Zhou, Ming-Yue, Shi, Tong, Yin, Hang, and Zhang, Bu-Tian

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, General Relativity and Quantum Cosmology
Abstract

TianQin is a proposed space-based gravitational wave observatory. It is designed to detect the gravitational wave signals in the frequency range of 0.1 mHz -- 1 Hz. At a geocentric distance of $10^5$ km, the plasma in the earth magnetosphere will contribute as the main source of environmental noises. Here, we analyze the acceleration noises that are caused by the magnetic field of space plasma for the test mass of TianQin. The real solar wind data observed by the Advanced Composition Explorer are taken as the input of the magnetohydrodynamic simulation. The Space Weather Modeling Framework is used to simulate the global magnetosphere of the earth, from which we obtain the plasma and magnetic field parameters on the detector's orbits. We calculate the time series of the residual accelerations and the corresponding amplitude spectral densities on these orbit configurations. We find that the residual acceleration produced by the interaction between the TM's magnetic moment induced by the space magnetic field and the spacecraft magnetic field ($\bm{a}_{\rm M1}$) is the dominant term, which can approach $10^{-15}$ m/s$^2$/Hz$^{1/2}$ at $f \approx$ 0.2 mHz for the nominal values of the magnetic susceptibility ($\chi_{\rm m} = 10^{-5}$) and the magnetic shielding factor ($\xi_{\rm m} = 10$) of the test mass. The ratios between the amplitude spectral density of the acceleration noise caused by the space magnetic field and the preliminary goal of the inertial sensor are 0.38 and 0.08 at 1 mHz and 10 mHz, respectively. We discuss the further reduction of this acceleration noise by decreasing $\chi_{\rm m}$ and/or increasing $\xi_{\rm m}$ in the future instrumentation development for TianQin., Comment: 21 pages, 9 figures; revised version, to be published in Classical and Quantum Gravity

Published
2020

15. iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy

Author

Cichocki, Frank, Bjordahl, Ryan, Gaidarova, Svetlana, Mahmood, Sajid, Abujarour, Ramzey, Wang, Hongbo, Tuininga, Katie, Felices, Martin, Davis, Zachary B, Bendzick, Laura, Clarke, Raedun, Stokely, Laurel, Rogers, Paul, Ge, Moyar, Robinson, Megan, Rezner, Betsy, Robbins, David L, Lee, Tom T, Kaufman, Dan S, Blazar, Bruce R, Valamehr, Bahram, and Miller, Jeffrey S

Subjects
Biotechnology, Vaccine Related, Cancer, Stem Cell Research - Induced Pluripotent Stem Cell, Immunization, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Stem Cell Research, Humans, Induced Pluripotent Stem Cells, Killer Cells, Natural, Neoplasms, Programmed Cell Death 1 Receptor, T-Lymphocytes, Biological Sciences, Medical and Health Sciences
Abstract

The development of immunotherapeutic monoclonal antibodies targeting checkpoint inhibitory receptors, such as programmed cell death 1 (PD-1), or their ligands, such as PD-L1, has transformed the oncology landscape. However, durable tumor regression is limited to a minority of patients. Therefore, combining immunotherapies with those targeting checkpoint inhibitory receptors is a promising strategy to bolster antitumor responses and improve response rates. Natural killer (NK) cells have the potential to augment checkpoint inhibition therapies, such as PD-L1/PD-1 blockade, because NK cells mediate both direct tumor lysis and T cell activation and recruitment. However, sourcing donor-derived NK cells for adoptive cell therapy has been limited by both cell number and quality. Thus, we developed a robust and efficient manufacturing system for the differentiation and expansion of high-quality NK cells derived from induced pluripotent stem cells (iPSCs). iPSC-derived NK (iNK) cells produced inflammatory cytokines and exerted strong cytotoxicity against an array of hematologic and solid tumors. Furthermore, we showed that iNK cells recruit T cells and cooperate with T cells and anti-PD-1 antibody, further enhancing inflammatory cytokine production and tumor lysis. Because the iNK cell derivation process uses a renewable starting material and enables the manufacturing of large numbers of doses from a single manufacture, iNK cells represent an "off-the-shelf" source of cells for immunotherapy with the capacity to target tumors and engage the adaptive arm of the immune system to make a "cold" tumor "hot" by promoting the influx of activated T cells to augment checkpoint inhibitor therapies.

Published
2020

16. Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Author

Zhu, Huang, Blum, Robert H, Bjordahl, Ryan, Gaidarova, Svetlana, Rogers, Paul, Lee, Tom Tong, Abujarour, Ramzey, Bonello, Gregory B, Wu, Jianming, Tsai, Pei-Fang, Miller, Jeffrey S, Walcheck, Bruce, Valamehr, Bahram, and Kaufman, Dan S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Immunology, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Stem Cell Research, Women's Health, Stem Cell Research - Induced Pluripotent Stem Cell, Cancer, Lymphatic Research, Hematology, Immunization, Biotechnology, Lymphoma, Ovarian Cancer, Rare Diseases, Immunotherapy, 5.2 Cellular and gene therapies, 2.1 Biological and endogenous factors, Animals, Antibodies, Monoclonal, Antibody-Dependent Cell Cytotoxicity, Antigens, CD20, Antineoplastic Agents, Immunological, Cell Line, Cell Line, Tumor, Female, Humans, Induced Pluripotent Stem Cells, Killer Cells, Natural, Lymphoma, B-Cell, Mice, Inbred NOD, Mice, SCID, Ovarian Neoplasms, Receptors, IgG, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Biochemistry and cell biology, Cardiovascular medicine and haematology, Paediatrics
Abstract

Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer (NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is facilitated by the Fc receptor CD16a on human NK cells. CD16a appears to be the only activating receptor on NK cells that is cleaved by the metalloprotease a disintegrin and metalloproteinase-17 upon stimulation. We previously demonstrated that a point mutation of CD16a prevents this activation-induced surface cleavage. This noncleavable CD16a variant is now further modified to include the high-affinity noncleavable variant of CD16a (hnCD16) and was engineered into human induced pluripotent stem cells (iPSCs) to create a renewable source for human induced pluripotent stem cell-derived NK (hnCD16-iNK) cells. Compared with unmodified iNK cells and peripheral blood-derived NK (PB-NK) cells, hnCD16-iNK cells proved to be highly resistant to activation-induced cleavage of CD16a. We found that hnCD16-iNK cells were functionally mature and exhibited enhanced ADCC against multiple tumor targets. In vivo xenograft studies using a human B-cell lymphoma demonstrated that treatment with hnCD16-iNK cells and anti-CD20 mAb led to significantly improved regression of B-cell lymphoma compared with treatment utilizing anti-CD20 mAb with PB-NK cells or unmodified iNK cells. hnCD16-iNK cells, combined with anti-HER2 mAb, also mediated improved survival in an ovarian cancer xenograft model. Together, these findings show that hnCD16-iNK cells combined with mAbs are highly effective against hematologic malignancies and solid tumors that are typically resistant to NK cell-mediated killing, demonstrating the feasibility of producing a standardized off-the-shelf engineered NK cell therapy with improved ADCC properties to treat malignancies that are otherwise refractory.

Published
2020

17. Atomic-scale origin of the interface resistivity in perovskite oxide solid electrolytes

Author

Lee, Tom

Subjects
Materials Science
Abstract

Oxide solid electrolytes (OSEs) have the potential to achieve improved safety and energy density for lithium-ion batteries, but their high grain-boundary (GB) resistivity generally is a bottleneck. In the well-studied perovskite oxide solid electrolyte, Li3xLa2/3-xTiO3 (LLTO), the ionic conductivity of grain boundaries is about three orders of magnitude lower than that of the bulk. In contrast, the related Li0.375Sr0.4375Ta0.75Zr0.25O3 (LSTZ) perovskite exhibits low grain boundary resistivity for reasons yet unknown. Here, we use aberration-corrected scanning transmission electron microscopy and spectroscopy, along with an active learning moment tensor potential, to reveal the atomic scale structure and composition of LSTZ grain boundaries. Vibrational electron energy loss spectroscopy is applied for the first time to reveal atomically resolved vibrations at grain boundaries of LSTZ and to characterize the otherwise unmeasurable Li distribution therein. We find that Li depletion, which is a major reason for the low grain boundary ionic conductivity of LLTO, is absent for the grain boundaries of LSTZ. Instead, the low grain boundary resistivity of LSTZ is attributed to the formation of a nanoscale defective cubic perovskite interfacial structure that contained abundant vacancies. Our study provides new insights into the atomic scale mechanisms of low grain boundary resistivity.To further improve the total ionic conductivity of LSTZ, we explore the wide compositional space of compositionally complex ceramics (CCCs). Herein, we propose and demonstrate strategies for tailoring CCCs via a combination of non-equimolar compositional designs and control of grain boundaries and microstructures. A class of compositionally complex perovskite oxides (CCPOs) with improved lithium ionic conductivities beyond the limit of conventional doping was discovered. For example, we demonstrate that the ionic conductivity can be improved by >60% in (Li0.375Sr0.4375)(Ta0.375Nb0.375Zr0.125Hf0.125)O3-d compared with the (Li0.375Sr0.4375)(Ta0.75Zr0.25)O3-d baseline that is synthesized using the same conditions. Furthermore, the ionic conductivity can be improved by another >70% via air quenching, achieving >270% of the LSTZ. Notably, we demonstrate GB enabled conductivity improvements via both promoting grain growth and altering GB structures through compositional designs and processing. In a broader perspective, this work suggests new routes for discovering and tailoring CCCs for energy storage and many other applications.In comparison with the ionic conductivities of the other compositions we have studied, i.e., (Li0.375Sr0.4375)(Ta0.75Zr0.125Hf0.125)O3, (Li0.375Sr0.4375)(Ta0.375Nb0.375Hf0.25)O3, (Li0.375Sr0.4375)(Ta0.375Nb0.375Zr0.25)O3, (Li0.375Sr0.4375)(Ta0.375Nb0.375Zr0.125Hf0.125)O3, and (Li0.375Sr0.4375)(Ta0.75Zr0.25)O3, the ionic conductivity of (Li0.375Sr0.4375)(Nb0.75Zr0.125Hf0.125)O3 (LSNZH) is at least one order of magnitude lower. This abnormally low total ionic conductivity intrigued us to investigate its microstructure. In depth investigation of periodic lattice and none-periodic features is crucial for understanding Li-ion transport in crystalline solid electrolytes. Identifying the crystal lattices of new Li-ion conductors has been a standard practice in physical science and is valuable for both pure and applied science. In comparison, the atomistic mechanisms that control the Li-ion migration of many non-periodic features are not as well studied. Herein, we discover a new atypical, ordered structure and a new self-interstitial point defect in solid electrolyte (Li0.375Sr0.4375)(Nb0.75Zr0.125Hf0.125)O3, and the names “Lee-Ko phase” and “defected Lee-Ko phase” are coined to describe them. The Lee-Ko phase degrades bulk ionic conductivity by its ordered structure. It also reduces the grain boundary ionic conductivity by creating a gradual change in composition at around the phase boundaries. In conclusion, both the Lee-Ko phase and defected Lee-Ko phase hinder Li-ion transport and are key factors contributing to the low total ionic conductivity of LSNZH perovskite solid electrolyte. Our discoveries highlight the importance of thoroughly investigating crystal lattices and none-periodic features and motivates similar studies for other solid electrolytes.

Published
2024

18. A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors

Author

Goulding, John, Yeh, Wen-I, Hancock, Bryan, Blum, Robert, Xu, Tianhao, Yang, Bi-Huei, Chang, Chia-Wei, Groff, Brian, Avramis, Earl, Pribadi, Mochtar, Pan, Yijia, Chu, Hui-Yi, Sikaroodi, Shohreh, Fong, Lauren, Brookhouser, Nicholas, Dailey, Thomas, Meza, Miguel, Denholtz, Matthew, Diaz, Evelyn, Martin, Judy, Szabo, Peter, Cooley, Sarah, Ferrari de Andrade, Lucas, Lee, Tom T., Bjordahl, Ryan, Wucherpfennig, Kai W., and Valamehr, Bahram

Published
2023
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20. Genetic architecture of subcortical brain structures in 38,851 individuals

Author

Satizabal, Claudia L, Adams, Hieab HH, Hibar, Derrek P, White, Charles C, Knol, Maria J, Stein, Jason L, Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V, Smith, Albert V, Bis, Joshua C, Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J, Yang, Jingyun, Yanek, Lisa R, Lee, Tom V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D, Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E, Kim, Sungeun, Hoehn, David, Armstrong, Nicola J, Chen, Qiang, Holmes, Avram J, den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K, Jones, Hannah J, Pike, G Bruce, Stein, Dan J, Stevens, Allison, Bralten, Janita, Vernooij, Meike W, Harris, Tamara B, Filippi, Irina, Witte, A Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H, Becker, James T, Doan, Nhat Trung, Hagenaars, Saskia P, Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M, Ames, David, Goldman, Aaron L, Lee, Phil H, Boomsma, Dorret I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M, Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M, Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E, Shin, Jean, Ipser, Jonathan C, Vinke, Louis N, Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K, Aribisala, Benjamin S, and Schmidt, Helena

Subjects
Biological Sciences, Genetics, Mental Health, Human Genome, Neurosciences, Brain Disorders, 2.1 Biological and endogenous factors, Neurological, Adult, Aged, Animals, Brain, Cohort Studies, Drosophila melanogaster, Genetic Variation, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Middle Aged, Neurodevelopmental Disorders, Organ Size, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Published
2019

21. Dual antigen–targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia

Author

Cichocki, Frank, Goodridge, Jodie P., Bjordahl, Ryan, Mahmood, Sajid, Davis, Zachary B., Gaidarova, Svetlana, Abujarour, Ramzey, Groff, Brian, Witty, Alec, Wang, Hongbo, Tuininga, Katie, Kodal, Behiye, Felices, Martin, Bonello, Greg, Huffman, Janel, Dailey, Thomas, Lee, Tom T., Walcheck, Bruce, Valamehr, Bahram, and Miller, Jeffrey S.

Published
2022
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22. Greater Transplant-Free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls

Author

Sturgess, Richard, Healey, Christopher, Gunasekera, Anton, Kallis, Yiannis, Wright, Gavin, Mathialahan, Thiriloganathan, Evans, Richard, Gasem, Jaber, Ramanaden, David, Ward, Emma, Bhalme, Mahesh, Southern, Paul, Maggs, James, Yousif, Mohamed, Mells, George, Srivastava, Brijesh, Foxton, Matthew, Collins, Carole, Prasad, Yash, Porras-Perez, Francisco, Yapp, Tom, Patel, Minesh, Ede, Roland, Carte, Martyn, Koss, Konrad, Sattianayagam, Prayman, Grimley, Charles, Tidbury, Jude, Mansour, Dina, Beckley, Matilda, Hollywood, Coral, Ramag, John, Gordon, Harriet, Ridpath, Joanne, Grover, Bob, Abouda, George, Rees, Ian, Narain, Mark, Salam, Imroz, Banim, Paul, Das, Debasish, Matthews, Helen, Mohammed, Faiyaz, Jones, Rebecca, Sen, Sambit, Bird, George, Prince, Martin, Prasad, Geeta, Kitchen, Paul, Hutchinson, John, Gupta, Prakash, Jones, David, Shah, Amir, Saha, Subrata, Pollock, Katharine, Barclay, Stephen, McDonald, Natasha, Rushbrook, Simon, Przemioslo, Robert, Millar, Andrew, Mitchell, Steven, Davis, Andrew, Naqvi, Asifabbas, Lee, Tom, Ryder, Stephen, Collier, Jane, Cramp, Matthew, Aspinal, Richard, Booth, Jonathan, Williams, Earl, Hussaini, Hyder, Christie, John, Chaudhry, Tehreem, Thorburn, Douglas, Mann, Stephen, Ala, Aftab, Maltby, Julia, Corbett, Chris, Singhal, Saket, Hoeroldt, Barbara, Butterworth, Jeff, Douglas, Andrew, Sinha, Rohit, Panter, Simon, Shearman, Jeremy, Bray, Gary, Roberts, Michael, Forton, Daniel, Taylor, Nicola, Jafar, Wisam, Cowan, Matthew, Ch'ng, Chin Lye, Rahman, Mesbah, Wesley, Emma, Jain, Sanjiv, Mandal, Aditya, Wright, Mark, Trivedi, Palak, Gordon, Fiona, Unitt, Esther, Austin, Andrew, Palegwala, Altaf, Vemala, Vishwaraj, Higham, Andrew, Fraser, Jocelyn, Li, Andy, Ramakrishnan, Subramaniam, King, Alistair, Whalley, Simon, Gee, Ian, Keld, Richard, Fellows, Helen, Gotto, James, Millson, Charles, Murillo Perez, C. Fiorella, Fisher, Holly, Hiu, Shaun, Kareithi, Dorcas, Adekunle, Femi, Mayne, Tracy, Malecha, Elizabeth, Ness, Erik, van der Meer, Adriaan J., Lammers, Willem J., Trivedi, Palak J., Battezzati, Pier Maria, Nevens, Frederik, Kowdley, Kris V., Bruns, Tony, Cazzagon, Nora, Floreani, Annarosa, Mason, Andrew L., Parés, Albert, Londoño, Maria-Carlota, Invernizzi, Pietro, Carbone, Marco, Lleo, Ana, Mayo, Marlyn J., Dalekos, George N., Gatselis, Nikolaos K., Verhelst, Xavier, Gulamhusein, Aliya, Janssen, Harry L.A., Smith, Rachel, Flack, Steve, Mulcahy, Victoria, Trauner, Michael, Bowlus, Christopher L., Lindor, Keith D., Corpechot, Christophe, Hirschfield, Gideon M., Wason, James, and Hansen, Bettina E.

Published
2022
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24. A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer

Author

Finer-Moore, Janet S, Lee, Tom T, and Stroud, Robert M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Binding Sites, Catalytic Domain, Crystallography, X-Ray, Escherichia coli, Folic Acid, Hydrogen, Models, Molecular, Mutation, Protein Conformation, Quinazolines, Substrate Specificity, Tetrahydrofolates, Thymidylate Synthase, Medicinal and Biomolecular Chemistry, Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medical biochemistry and metabolomics, Medicinal and biomolecular chemistry
Abstract

In Escherichia coli thymidylate synthase (EcTS), rate-determining hydride transfer from the cofactor 5,10-methylene-5,6,7,8-tetrahydrofolate to the intermediate 5-methylene-2'-deoxyuridine 5'-monophosphate occurs by hydrogen tunneling, requiring precise alignment of reactants and a closed binding cavity, sealed by the C-terminal carboxyl group. Mutations that destabilize the closed conformation of the binding cavity allow small molecules such as β-mercaptoethanol (β-ME) to enter the active site and compete with hydride for addition to the 5-methylene group of the intermediate. The C-terminal deletion mutant of EcTS produced the β-ME adduct in proportions that varied dramatically with cofactor concentration, from 50% at low cofactor concentrations to 0% at saturating cofactor conditions, suggesting communication between active sites. We report the 2.4 Å X-ray structure of the C-terminal deletion mutant of E. coli TS in complex with a substrate and a cofactor analogue, CB3717. The structure is asymmetric, with reactants aligned in a manner consistent with hydride transfer in only one active site. In the second site, CB3717 has shifted to a site where the normal cofactor would be unlikely to form 5-methylene-2'-deoxyuridine 5'-monophosphate, consistent with no formation of the β-ME adduct. The structure shows how the binding of the cofactor at one site triggers hydride transfer and borrows needed stabilization from substrate binding at the second site. It indicates pathways through the dimer interface that contribute to allostery relevant to half-sites reactivity.

Published
2018

25. Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Author

Cichocki, Frank, Bjordahl, Ryan, Goodridge, Jodie P., Mahmood, Sajid, Gaidarova, Svetlana, Abujarour, Ramzey, Davis, Zachary B., Merino, Aimee, Tuininga, Katie, Wang, Hongbo, Kumar, Akhilesh, Groff, Brian, Witty, Alec, Bonello, Greg, Huffman, Janel, Dailey, Thomas, Lee, Tom T., Malmberg, Karl-Johan, Walcheck, Bruce, Höpken, Uta, Rehm, Armin, Valamehr, Bahram, and Miller, Jeffrey S.

Published
2022
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27. Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

Author

Woan, Karrune V., Kim, Hansol, Bjordahl, Ryan, Davis, Zachary B., Gaidarova, Svetlana, Goulding, John, Hancock, Brian, Mahmood, Sajid, Abujarour, Ramzey, Wang, Hongbo, Tuininga, Katie, Zhang, Bin, Wu, Cheng-Ying, Kodal, Behiye, Khaw, Melissa, Bendzick, Laura, Rogers, Paul, Ge, Moyar Qing, Bonello, Greg, Meza, Miguel, Felices, Martin, Huffman, Janel, Dailey, Thomas, Lee, Tom T., Walcheck, Bruce, Malmberg, Karl J., Blazar, Bruce R., Bryceson, Yenan T., Valamehr, Bahram, Miller, Jeffrey S., and Cichocki, Frank

Published
2021
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29. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Author

Siminovitch, Katherine A., Hirschfield, Gideon M., Mason, Andrew, Vincent, Catherine, Xie, Gang, Zhang, Jinyi, Tang, Ruqi, Ma, Xiong, Li, Zhiqiang, Shi, Yongyong, Affronti, Andrea, Almasio, Piero L., Alvaro, Domenico, Andreone, Pietro, Andriulli, Angelo, Azzaroli, Francesco, Battezzati, Pier Maria, Benedetti, Antonio, Bragazzi, MariaConsiglia, Brunetto, Maurizia, Bruno, Savino, Calvaruso, Vincenza, Cardinale, Vincenzo, Casella, Giovanni, Cazzagon, Nora, Ciaccio, Antonio, Coco, Barbara, Colli, Agostino, Colloredo, Guido, Colombo, Massimo, Colombo, Silvia, Cristoferi, Laura, Cursaro, Carmela, Crocè, Lory Saveria, Crosignani, Andrea, D’Amato, Daphne, Donato, Francesca, Elia, Gianfranco, Fabris, Luca, Fagiuoli, Stefano, Ferrari, Carlo, Floreani, Annarosa, Galli, Andrea, Giannini, Edoardo, Grattagliano, Ignazio, Lampertico, Pietro, Lleo, Ana, Malinverno, Federica, Mancuso, Clara, Marra, Fabio, Marzioni, Marco, Massironi, Sara, Mattalia, Alberto, Miele, Luca, Milani, Chiara, Morini, Lorenzo, Morisco, Filomena, Muratori, Luigi, Muratori, Paolo, Niro, Grazia A., O’Donnell, Sarah, Picciotto, Antonio, Portincasa, Piero, Rigamonti, Cristina, Ronca, Vincenzo, Rosina, Floriano, Spinzi, Giancarlo, Strazzabosco, Mario, Tarocchi, Mirko, Tiribelli, Claudio, Toniutto, Pierluigi, Valenti, Luca, Vinci, Maria, Zuin, Massimo, Nakamura, Hitomi, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Ishibashi, Hiromi, Ito, Masahiro, Migita, Kiyoshi, Ohira, Hiromasa, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ota, Hajime, Komura, Takuya, Nakamura, Yoko, Shimada, Masaaki, Hirashima, Noboru, Komeda, Toshiki, Ario, Keisuke, Nakamuta, Makoto, Yamashita, Tsutomu, Furuta, Kiyoshi, Kikuchi, Masahiro, Naeshiro, Noriaki, Takahashi, Hironao, Mano, Yutaka, Tsunematsu, Seiji, Yabuuchi, Iwao, Shimada, Yusuke, Yamauchi, Kazuhiko, Sugimoto, Rie, Sakai, Hironori, Mita, Eiji, Koda, Masaharu, Tsuruta, Satoru, Kamitsukasa, Hiroshi, Sato, Takeaki, Masaki, Naohiko, Kobata, Tatsuro, Fukushima, Nobuyoshi, Ohara, Yukio, Muro, Toyokichi, Takesaki, Eiichi, Takaki, Hitoshi, Yamamoto, Tetsuo, Kato, Michio, Nagaoki, Yuko, Hayashi, Shigeki, Ishida, Jinya, Watanabe, Yukio, Kobayashi, Masakazu, Koga, Michiaki, Saoshiro, Takeo, Yagura, Michiyasu, Hirata, Keisuke, Tanaka, Atsushu, Takikawa, Hajime, Zeniya, Mikio, Abe, Masanori, Onji, Morikazu, Kaneko, Shuichi, Honda, Masao, Arai, Kuniaki, Arinaga-Hino, Teruko, Hashimoto, Etsuko, Taniai, Makiko, Umemura, Takeji, Joshita, Satoru, Nakao, Kazuhiko, Ichikawa, Tatsuki, Shibata, Hidetaka, Yamagiwa, Satoshi, Seike, Masataka, Honda, Koichi, Sakisaka, Shotaro, Takeyama, Yasuaki, Harada, Masaru, Senju, Michio, Yokosuka, Osamu, Kanda, Tatsuo, Ueno, Yoshiyuki, Kikuchi, Kentaro, Ebinuma, Hirotoshi, Himoto, Takashi, Yasunami, Michio, Murata, Kazumoto, Mizokami, Masashi, Kawata, Kazuhito, Shimoda, Shinji, Miyake, Yasuhiro, Takaki, Akinobu, Yamamoto, Kazuhide, Hirano, Katsuji, Ichida, Takafumi, Ido, Akio, Tsubouchi, Hirohito, Chayama, Kazuaki, Harada, Kenichi, Nakanuma, Yasuni, Maehara, Yoshihiko, Taketomi, Akinobu, Shirabe, Ken, Soejima, Yuji, Mori, Akira, Yagi, Shintaro, Uemoto, Shinji, H, Egawa, Tanaka, Tomohiro, Yamashiki, Noriyo, Tamura, Sumito, Sugawara, Yasuhiro, Kokudo, Norihiro, Juran, Brian D., Atkinson, Elizabeth J., Cheung, Angela, de Andrade, Mariza, Lazaridis, Konstantinos N., Chalasani, Naga, Luketic, Vel, Odin, Joseph, Chopra, Kapil, Baras, Aris, Horowitz, Julie, Abecasis, Goncalo, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mitnaul, Lyndon J., Sturgess, Richard, Healey, Christopher, Yeoman, Andrew, Gunasekera, Anton VJ., Kooner, Paul, Kapur, Kapil, Sathyanarayana, V., Kallis, Yiannis, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Rooney, Paul, Ramanaden, David, Evans, Richard, Mathialahan, Thiriloganathan, Gasem, Jaber, Shorrock, Christopher, Bhalme, Mahesh, Southern, Paul, Tibble, Jeremy A., Gorard, David A., Jones, Susan, Mells, George, Mulcahy, Victoria, Srivastava, Brijesh, Foxton, Matthew R., Collins, Carole E., Elphick, David, Karmo, Mazn, Porras-Perez, Francisco, Mendall, Michael, Yapp, Tom, Patel, Minesh, Ede, Roland, Sayer, Joanne, Jupp, James, Fisher, Neil, Carter, Martyn J., Koss, Konrad, Shah, Jayshri, Piotrowicz, Andrzej, Scott, Glyn, Grimley, Charles, Gooding, Ian R., Williams, Simon, Tidbury, Judith, Lim, Guan, Cheent, Kuldeep, Levi, Sass, Mansour, Dina, Beckley, Matilda, Hollywood, Coral, Wong, Terry, Marley, Richard, Ramage, John, Gordon, Harriet M., Ridpath, Jo, Ngatchu, Theodore, Bob Grover, Vijay Paul, Shidrawi, Ray G., Abouda, George, Corless, L., Narain, Mark, Rees, Ian, Brown, Ashley, Taylor-Robinson, Simon, Wilkins, Joy, Grellier, Leonie, Banim, Paul, Das, Debasish, Heneghan, Michael A., Curtis, Howard, Matthews, Helen C., Mohammed, Faiyaz, Aldersley, Mark, Srirajaskanthan, Raj, Walker, Giles, McNair, Alistair, Sharif, Amar, Sen, Sambit, Bird, George, Prince, Martin I., Prasad, Geeta, Kitchen, Paul, Barnardo, Adrian, Oza, Chirag, Sivaramakrishnan, Nurani N., Gupta, Prakash, Shah, Amir, Evans, Chris DJ., Saha, Subrata, Pollock, Katharine, Bramley, Peter, Mukhopadhya, Ashis, Barclay, Stephen T., McDonald, Natasha, Bathgate, Andrew J., Palmer, Kelvin, Dillon, John F., Rushbrook, Simon M., Przemioslo, Robert, McDonald, Chris, Millar, Andrew, Tai, Cheh, Mitchell, Stephen, Metcalf, Jane, Shaukat, Syed, Ninkovic, Mary, Shmueli, Udi, Davis, Andrew, Naqvi, Asifabbas, Lee, Tom JW., Ryder, Stephen, Collier, Jane, Klass, Howard, Cramp, Matthew E., Sharer, Nichols, Aspinall, Richard, Ghosh, Deb, Douds, Andrew C., Booth, Jonathan, Williams, Earl, Hussaini, Hyder, Christie, John, Mann, Steven, Thorburn, Douglas, Marshall, Aileen, Patanwala, Imran, Ala, Aftab, Maltby, Julia, Matthew, Ray, Corbett, Chris, Vyas, Sam, Singhal, Saket, Gleeson, Dermot, Misra, Sharat, Butterworth, Jeff, George, Keith, Harding, Tim, Douglass, Andrew, Mitchison, Harriet, Panter, Simon, Shearman, Jeremy, Bray, Gary, Roberts, Michael, Butcher, Graham, Forton, Daniel, Mahmood, Zahid, Cowan, Matthew, Das, Debashis, Ch’ng, Chin Lye, Rahman, Mesbah, Whatley, Gregory C.A., Wesley, Emma, Mandal, Aditya, Jain, Sanjiv, Pereira, Stephen P., Wright, Mark, Trivedi, Palak, Gordon, Fiona H., Unitt, Esther, Palejwala, Altaf, Austin, Andrew, Vemala, Vishwaraj, Grant, Allister, Higham, Andrew D., Brind, Alison, Mathew, Ray, Cox, Mark, Ramakrishnan, Subramaniam, King, Alistair, Whalley, Simon, Fraser, Jocelyn, Thomson, S.J., Bell, Andrew, Wong, Voi Shim, Kia, Richard, Gee, Ian, Keld, Richard, Ransford, Rupert, Gotto, James, Millson, Charles, Cordell, Heather J., Fryett, James J., Ueno, Kazuko, Darlay, Rebecca, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Khor, Seik-Soon, Gervais, Olivier, Kawai, Yosuke, Nagasaki, Masao, Tokunaga, Katsushi, Gerussi, Alessio, Carbone, Marco, Asselta, Rosanna, Ferreira, Manuel A.R., Sun, Dylan, Jones, David E., Flack, Steven, Spicer, Ann, Mulcahy, Victoria L., Byan, Jinyoung, Han, Younghun, Sandford, Richard N., Amos, Christopher I., Seldin, Michael F., Invernizzi, Pietro, Nakamura, Minoru, and Mells, George F.

Published
2021
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30. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author

Walker, Erin, Xie, Gang, Mason, Andy, Myers, Robert, Peltekian, Kevork, Ghent, Cameron, Atkinson, Elizabeth, Juran, Bruce, Lazaridis, Kostas, Lu, Yue, Gu, Xiangjun, Jing, Kaiyan, Amos, Chris, Affronti, Andrea, Brunetto, Maurizia, Coco, Barbara, Spinzi, Giancarlo, Elia, Gianfranco, Ferrari, Carlo, Lleo, Ana, Muratori, Luigi, Muratori, Paolo, Portincasa, Piero, Colli, Agostino, Bruno, Savino, Colloredo, Guido, Azzaroli, Francesco, Andreone, Pietro, Bragazzi, MariaConsiglia, Alvaro, Domenico, Cardinale, Vincenzo, Cazzagon, Nora, Rigamonti, Cristina, Floreani, Annarosa, Rosina, Floriano, Ciaccio, Antonio, Cristoferi, Laura, D’Amato, Daphne, Malinverno, Federica, Mancuso, Clara, Massironi, Sara, Milani, Chiara, O’Donnell, Sarah E., Ronca, Vincenzo, Barisani, Donatella, Lampertico, Pietro, Donato, Francesca, Fagiuoli, Stefano, Almasio, Piero L., Giannini, Edoardo, Cursaro, Carmela, Colombo, Massimo, Valenti, Luca, Miele, Luca, Andriulli, Angelo, Niro, Grazia A., Grattagliano, Ignazio, Morini, Lorenzo, Casella, Giovanni, Vinci, Maria, Battezzati, Pier Maria, Crosignani, Andrea, Zuin, Massimo, Mattalia, Alberto, Calvaruso, Vincenza, Colombo, Silvia, Benedetti, Antonio, Marzioni, Marco, Galli, Andrea, Marra, Fabio, Tarocchi, Mirko, Picciotto, Antonio, Morisco, Filomena, Fabris, Luca, Crocè, Lory Saveria, Tiribelli, Claudio, Toniutto, Pierluigi, Strazzabosco, Mario, Ch’ng, Chin Lye, Rahman, Mesbah, Yapp, Tom, Sturgess, Richard, Healey, Christopher, Czajkowski, Marek, Gunasekera, Anton, Gyawali, Pranab, Premchand, Purushothaman, Kapur, Kapil, Marley, Richard, Foster, Graham, Watson, Alan, Dias, Aruna, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Ramanaden, David, Gasem, Jaber, Evans, Richard, Mathialahan, Thiriloganathan, Shorrock, Christopher, Lipscomb, George, Southern, Paul, Tibble, Jeremy, Gorard, David, Palegwala, Altaf, Jones, Susan, Dawwas, Mohamed, Alexander, Graeme, Dolwani, Sunil, Prince, Martin, Foxton, Matthew, Elphick, David, Mitchison, Harriet, Gooding, Ian, Karmo, Mazn, Saksena, Sushma, Mendall, Mike, Patel, Minesh, Ede, Roland, Austin, Andrew, Sayer, Joanna, Hankey, Lorraine, Hovell, Christopher, Fisher, Neil, Carter, Martyn, Koss, Konrad, Piotrowicz, Andrzej, Grimley, Charles, Neal, David, Lim, Guan, Levi, Sass, Ala, Aftab, Broad, Andrea, Saeed, Athar, Wood, Gordon, Brown, Jonathan, Wilkinson, Mark, Gordon, Harriet, Ramage, John, Ridpath, Jo, Ngatchu, Theodore, Grover, Bob, Shaukat, Syed, Shidrawi, Ray, Abouda, George, Ali, Faiz, Rees, Ian, Salam, Imroz, Narain, Mark, Brown, Ashley, Taylor-Robinson, Simon, Williams, Simon, Grellier, Leonie, Banim, Paul, Das, Debasish, Chilton, Andrew, Heneghan, Michael, Curtis, Howard, Gess, Markus, Drake, Ian, Aldersley, Mark, Davies, Mervyn, Jones, Rebecca, McNair, Alastair, Srirajaskanthan, Raj, Pitcher, Maxton, Sen, Sambit, Bird, George, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Chirag, Oza, Sivaramakrishnan, Nurani, MacFaul, George, Jones, David, Shah, Amir, Evans, Chris, Saha, Subrata, Pollock, Katharine, Bramley, Peter, Mukhopadhya, Ashis, Fraser, Andrew, Mills, Peter, Shallcross, Christopher, Campbell, Stewart, Bathgate, Andrew, Shepherd, Alan, Dillon, John, Rushbrook, Simon, Przemioslo, Robert, Macdonald, Christopher, Metcalf, Jane, Shmueli, Udi, Davis, Andrew, Naqvi, Asifabbas, Lee, Tom, Ryder, Stephen D., Collier, Jane, Klass, Howard, Ninkovic, Mary, Cramp, Matthew, Sharer, Nicholas, Aspinall, Richard, Goggin, Patrick, Ghosh, Deb, Douds, Andrew, Hoeroldt, Barbara, Booth, Jonathan, Williams, Earl, Hussaini, Hyder, Stableforth, William, Ayres, Reuben, Thorburn, Douglas, Marshall, Eileen, Burroughs, Andrew, Mann, Steven, Lombard, Martin, Richardson, Paul, Patanwala, Imran, Maltby, Julia, Brookes, Matthew, Mathew, Ray, Vyas, Samir, Singhal, Saket, Gleeson, Dermot, Misra, Sharat, Butterworth, Jeff, George, Keith, Harding, Tim, Douglass, Andrew, Panter, Simon, Shearman, Jeremy, Bray, Gary, Butcher, Graham, Forton, Daniel, Mclindon, John, Cowan, Matthew, Whatley, Gregory, Mandal, Aditya, Gupta, Hemant, Sanghi, Pradeep, Jain, Sanjiv, Pereira, Steve, Prasad, Geeta, Watts, Gill, Wright, Mark, Neuberger, James, Gordon, Fiona, Unitt, Esther, Grant, Allister, Delahooke, Toby, Higham, Andrew, Brind, Alison, Cox, Mark, Ramakrishnan, Subramaniam, King, Alistair, Collins, Carole, Whalley, Simon, Li, Andy, Fraser, Jocelyn, Bell, Andrew, Wong, Voi Shim, Singhal, Amit, Gee, Ian, Ang, Yeng, Ransford, Rupert, Gotto, James, Millson, Charles, Bowles, Jane, Thomas, Caradog, Harrison, Melanie, Galaska, Roman, Kendall, Jennie, Whiteman, Jessica, Lawlor, Caroline, Gray, Catherine, Elliott, Keith, Mulvaney-Jones, Caroline, Hobson, Lucie, Van Duyvenvoorde, Greta, Loftus, Alison, Seward, Katie, Penn, Ruth, Maiden, Jane, Damant, Rose, Hails, Janeane, Cloudsdale, Rebecca, Silvestre, Valeria, Glenn, Sue, Dungca, Eleanor, Wheatley, Natalie, Doyle, Helen, Kent, Melanie, Hamilton, Caroline, Braim, Delyth, Wooldridge, Helen, Abrahams, Rachel, Paton, Alison, Lancaster, Nicola, Gibbins, Andrew, Hogben, Karen, Desousa, Phillipa, Muscariu, Florin, Musselwhite, Janine, McKay, Alexandra, Tan, LaiTing, Foale, Carole, Brighton, Jacqueline, Flahive, Kerry, Nambela, Estelle, Townshend, Paula, Ford, Chris, Holder, Sophie, Palmer, Caroline, Featherstone, James, Nasseri, Mariam, Sadeghian, Joy, Williams, Bronwen, Thomas, Carol, Rolls, Sally-Ann, Hynes, Abigail, Duggan, Claire, Jones, Sarah, Crossey, Mary, Stansfield, Glynis, MacNicol, Carolyn, Wilkins, Joy, Wilhelmsen, Elva, Raymode, Parizade, Lee, Hye-Jeong, Durant, Emma, Bishop, Rebecca, Ncube, Noma, Tripoli, Sherill, Casey, Rebecca, Cowley, Caroline, Miller, Richard, Houghton, Kathryn, Ducker, Samantha, Wright, Fiona, Bird, Bridget, Baxter, Gwen, Keggans, Janie, Hughes, Maggie, Grieve, Emma, Young, Karin, Williams, D., Ocker, Kate, Hines, Frances, Martin, Kirsty, Innes, Caron, Valliani, Talal, Fairlamb, Helen, Thornthwaite, Sarah, Eastick, Anne, Tanqueray, Elizabeth, Morrison, Jennifer, Holbrook, Becky, Browning, Julie, Walker, Kirsten, Congreave, Susan, Verheyden, Juliette, Slininger, Susan, Stafford, Lizzie, O’Donnell, Denise, Ainsworth, Mark, Lord, Susan, Kent, Linda, March, Linda, Dickson, Christine, Simpson, Diane, Longhurst, Beverley, Hayes, Maria, Shpuza, Ervin, White, Nikki, Besley, Sarah, Pearson, Sallyanne, Wright, Alice, Jones, Linda, Gunter, Emma, Dewhurst, Hannah, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Marriott, Suzie, Leoni, Marina, Tyrer, David, Martin, Kate, Dali-kemmery, Lola, Lambourne, Victoria, Green, Marie, Sirdefield, Dawn, Amor, Kelly, Colley, Julie, Shinder, Bal, Jones, Jayne, Mills, Marisa, Carnahan, Mandy, Taylor, Natalie, Boulton, Kerenza, Tregonning, Julie, Brown, Carly, Clifford, Gayle, Archer, Emily, Hamilton, Maria, Curtis, Janette, Shewan, Tracey, Walsh, Sue, Warner, Karen, Netherton, Kimberley, Mupudzi, Mcdonald, Gunson, Bridget, Gitahi, Jane, Gocher, Denise, Batham, Sally, Pateman, Hilary, Desmennu, Senayon, Conder, Jill, Clement, Darren, Gallagher, Susan, Orpe, Jacky, Chan, PuiChing, Currie, Lynn, O’Donohoe, Lynn, Oblak, Metod, Morgan, Lisa, Quinn, Marie, Amey, Isobel, Baird, Yolanda, Cotterill, Donna, Cumlat, Lourdes, Winter, Louise, Greer, Sandra, Spurdle, Katie, Allison, Joanna, Dyer, Simon, Sweeting, Helen, Kordula, Jean, Aiba, Yoshihiro, Nakamura, Hitomi, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Ishibashi, Hiromi, Ito, Masahiro, Kawai, Yosuke, Kohn, Seik-Soon, Gervais, Olivier, Migita, Kiyoshi, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ota, Hajime, Komura, Takuya, Nakamura, Yoko, Shimada, Masaaki, Hirashima, Noboru, Komeda, Toshiki, Ario, Keisuke, Nakamuta, Makoto, Yamashita, Tsutomu, Furuta, Kiyoshi, Kikuchi, Masahiro, Naeshiro, Noriaki, Takahashi, Hironao, Mano, Yutaka, Tsunematsu, Seiji, Yabuuchi, Iwao, Shimada, Yusuke, Yamauchi, Kazuhiko, Sugimoto, Rie, Sakai, Hironori, Mita, Eiji, Koda, Masaharu, Tsuruta, Satoru, Kamitsukasa, Hiroshi, Sato, Takeaki, Masaki, Naohiko, Kobata, Tatsuro, Fukushima, Nobuyoshi, Higuchi, Nobito, Ohara, Yukio, Muro, Toyokichi, Takesaki, Eiichi, Takaki, Hitoshi, Yamamoto, Tetsuo, Kato, Michio, Nagaoki, Yuko, Hayashi, Shigeki, Ishida, Jinya, Watanabe, Yukio, Kobayashi, Masakazu, Koga, Michiaki, Saoshiro, Takeo, Yagura, Michiyasu, Hirata, Keisuke, Takikawa, Hajime, Ohira, Hiromasa, Zeniya, Mikio, Abe, Masanori, Onji, Morikazu, Kaneko, Shuichi, Honda, Masao, Arai, Kuniaki, Arinaga-Hino, Teruko, Hashimoto, Etsuko, Taniai, Makiko, Umemura, Takeji, Joshita, Satoru, Nakao, Kazuhiko, Ichikawa, Tatsuki, Shibata, Hidetaka, Yamagiwa, Satoshi, Seike, Masataka, Honda, Koichi, Sakisaka, Shotaro, Takeyama, Yasuaki, Harada, Masaru, Senju, Michio, Yokosuka, Osamu, Kanda, Tatsuo, Ueno, Yoshiyuki, Kikuchi, Kentaro, Ebinuma, Hirotoshi, Himoto, Takashi, Yasunami, Michio, Murata, Kazumoto, Mizokami, Masashi, Shimoda, Shinji, Miyake, Yasuhiro, Takaki, Akinobu, Yamamoto, Kazuhide, Hirano, Katsuji, Ichida, Takafumi, Ido, Akio, Tsubouchi, Hirohito, Chayama, Kazuaki, Harada, Kenichi, Nakanuma, Yasuni, Maehara, Yoshihiko, Taketomi, Akinobu, Shirabe, Ken, Soejima, Yuji, Mori, Akira, Yagi, Shintaro, Uemoto, Shinji, Tanaka, Tomohiro, Yamashiki, Noriyo, Tamura, Sumito, Sugawara, Yasuhiro, Kokudo, Norihiro, Asselta, Rosanna, Paraboschi, Elvezia M., Gerussi, Alessio, Cordell, Heather J., Mells, George F., Sandford, Richard N., Jones, David E., Nakamura, Minoru, Ueno, Kazuko, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Tokunaga, Katsushi, Nagasaki, Masao, Tanaka, Atsushi, Tang, Ruqi, Li, Zhiqiang, Shi, Yongyong, Liu, Xiangdong, Xiong, Ma, Hirschfield, Gideon, Siminovitch, Katherine A., Carbone, Marco, Cardamone, Giulia, Duga, Stefano, Gershwin, M. Eric, Seldin, Michael F., and Invernizzi, Pietro

Published
2021
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31. Imprinted NanoVelcro Microchips for Isolation and Characterization of Circulating Fetal Trophoblasts: Toward Noninvasive Prenatal Diagnostics

Author

Hou, Shuang, Chen, Jie-Fu, Song, Min, Zhu, Yazhen, Jan, Yu Jen, Chen, Szu Hao, Weng, Tzu-Hua, Ling, Dean-An, Chen, Shang-Fu, Ro, Tracy, Liang, An-Jou, Lee, Tom, Jin, Helen, Li, Man, Liu, Lian, Hsiao, Yu-Sheng, Chen, Peilin, Yu, Hsiao-Hua, Tsai, Ming-Song, Pisarska, Margareta D, Chen, Angela, Chen, Li-Ching, and Tseng, Hsian-Rong

Subjects
Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Genetics, Human Genome, Pediatric, Biotechnology, Reproductive health and childbirth, Adolescent, Adult, Comparative Genomic Hybridization, DNA, Female, Genetic Testing, Humans, Immunohistochemistry, Male, Trisomy, Trophoblasts, Young Adult, noninvasive prenatal testing, nanoVelcro assays, circulating trophoblasts, single-cell analysis, array comparative genomic hybridization, Nanoscience & Nanotechnology
Abstract

Circulating fetal nucleated cells (CFNCs) in maternal blood offer an ideal source of fetal genomic DNA for noninvasive prenatal diagnostics (NIPD). We developed a class of nanoVelcro microchips to effectively enrich a subcategory of CFNCs, i.e., circulating trophoblasts (cTBs) from maternal blood, which can then be isolated with single-cell resolution by a laser capture microdissection (LCM) technique for downstream genetic testing. We first established a nanoimprinting fabrication process to prepare the LCM-compatible nanoVelcro substrates. Using an optimized cTB-capture condition and an immunocytochemistry protocol, we were able to identify and isolate single cTBs (Hoechst+/CK7+/HLA-G+/CD45-, 20 μm > sizes > 12 μm) on the imprinted nanoVelcro microchips. Three cTBs were polled to ensure reproducible whole genome amplification on the cTB-derived DNA, paving the way for cTB-based array comparative genomic hybridization (aCGH) and short tandem repeats analysis. Using maternal blood samples collected from expectant mothers carrying a single fetus, the cTB-derived aCGH data were able to detect fetal genders and chromosomal aberrations, which had been confirmed by standard clinical practice. Our results support the use of nanoVelcro microchips for cTB-based noninvasive prenatal genetic testing, which holds potential for further development toward future NIPD solution.

Published
2017

32. A Framework for Symmetric Part Detection in Cluttered Scenes

Author

Lee, Tom, Fidler, Sanja, Levinshtein, Alex, Sminchisescu, Cristian, and Dickinson, Sven

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

The role of symmetry in computer vision has waxed and waned in importance during the evolution of the field from its earliest days. At first figuring prominently in support of bottom-up indexing, it fell out of favor as shape gave way to appearance and recognition gave way to detection. With a strong prior in the form of a target object, the role of the weaker priors offered by perceptual grouping was greatly diminished. However, as the field returns to the problem of recognition from a large database, the bottom-up recovery of the parts that make up the objects in a cluttered scene is critical for their recognition. The medial axis community has long exploited the ubiquitous regularity of symmetry as a basis for the decomposition of a closed contour into medial parts. However, today's recognition systems are faced with cluttered scenes, and the assumption that a closed contour exists, i.e. that figure-ground segmentation has been solved, renders much of the medial axis community's work inapplicable. In this article, we review a computational framework, previously reported in Lee et al. (2013), Levinshtein et al. (2009, 2013), that bridges the representation power of the medial axis and the need to recover and group an object's parts in a cluttered scene. Our framework is rooted in the idea that a maximally inscribed disc, the building block of a medial axis, can be modeled as a compact superpixel in the image. We evaluate the method on images of cluttered scenes., Comment: 10 pages, 8 figures

Published
2015

34. A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

Author

Wong, Ee Tsin, Szostak, Justyna, Titz, Bjoern, Lee, Tom, Wong, Sin Kei, Lavrynenko, Oksana, Merg, Celine, Corciulo, Maica, Simicevic, Jovan, Auberson, Mehdi, Peric, Dariusz, Dulize, Remi, Bornand, David, Loh, Guo Jie, Lee, Kyeonghee Monica, Zhang, Jingjie, Miller, IV, John H., Schlage, Walter K., Guedj, Emmanuel, Schneider, Thomas, Phillips, Blaine, Leroy, Patrice, Choukrallah, Mohamed Amin, Sierro, Nicolas, Buettner, Ansgar, Xiang, Yang, Kuczaj, Arkadiusz, Ivanov, Nikolai V., Luettich, Karsta, Vanscheeuwijck, Patrick, Peitsch, Manuel C., and Hoeng, Julia

Published
2021
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35. Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Author

Wan, Ying-Wooi, Al-Ouran, Rami, Mangleburg, Carl G., Perumal, Thanneer M., Lee, Tom V., Allison, Katherine, Swarup, Vivek, Funk, Cory C., Gaiteri, Chris, Allen, Mariet, Wang, Minghui, Neuner, Sarah M., Kaczorowski, Catherine C., Philip, Vivek M., Howell, Gareth R., Martini-Stoica, Heidi, Zheng, Hui, Mei, Hongkang, Zhong, Xiaoyan, Kim, Jungwoo Wren, Dawson, Valina L., Dawson, Ted M., Pao, Ping-Chieh, Tsai, Li-Huei, Haure-Mirande, Jean-Vianney, Ehrlich, Michelle E., Chakrabarty, Paramita, Levites, Yona, Wang, Xue, Dammer, Eric B., Srivastava, Gyan, Mukherjee, Sumit, Sieberts, Solveig K., Omberg, Larsson, Dang, Kristen D., Eddy, James A., Snyder, Phil, Chae, Yooree, Amberkar, Sandeep, Wei, Wenbin, Hide, Winston, Preuss, Christoph, Ergun, Ayla, Ebert, Phillip J., Airey, David C., Mostafavi, Sara, Yu, Lei, Klein, Hans-Ulrich, Carter, Gregory W., Collier, David A., Golde, Todd E., Levey, Allan I., Bennett, David A., Estrada, Karol, Townsend, T. Matthew, Zhang, Bin, Schadt, Eric, De Jager, Philip L., Price, Nathan D., Ertekin-Taner, Nilüfer, Liu, Zhandong, Shulman, Joshua M., Mangravite, Lara M., and Logsdon, Benjamin A.

Published
2020
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38. Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

Author

Ho, Jenny, Sciuscio, Davide, Kogel, Ulrike, Titz, Bjoern, Leroy, Patrice, Vuillaume, Gregory, Talikka, Marja, Martin, Elyette, Pospisil, Pavel, Lebrun, Stefan, Xia, Wenhao, Lee, Tom, Chng, Yun Xuan, Phillips, Blaine W., Veljkovic, Emilija, Guedj, Emmanuel, Xiang, Yang, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, and Vanscheeuwijck, Patrick

Published
2020
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40. A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer

Author

Jiang, Runze, Lu, Yi-Tsung, Ho, Hao, Li, Bo, Chen, Jie-Fu, Lin, Millicent, Li, Fuqiang, Wu, Kui, Wu, Hanjie, Lichterman, Jake, Wan, Haolei, Lu, Chia-Lun, OuYang, William, Ni, Ming, Wang, Linlin, Li, Guibo, Lee, Tom, Zhang, Xiuqing, Yang, Jonathan, Rettig, Matthew, Chung, Leland WK, Yang, Huanming, Li, Ker-Chau, Hou, Yong, Tseng, Hsian-Rong, Hou, Shuang, Xu, Xun, Wang, Jun, and Posadas, Edwin M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Genetics, Biotechnology, Urologic Diseases, Clinical Research, Human Genome, Prostate Cancer, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Base Sequence, Biomarkers, Tumor, Biopsy, Cell Separation, Chromosomes, Human, DNA Mutational Analysis, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Rearrangement, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Humans, Laser Capture Microdissection, Liver Neoplasms, Male, Molecular Sequence Data, Mutation, Nanotechnology, Neoplastic Cells, Circulating, Oligonucleotide Array Sequence Analysis, Phenotype, Polymorphism, Single Nucleotide, Predictive Value of Tests, Prostatic Neoplasms, Time Factors, circulating tumor cell, prostate cancer, whole genome sequencing, liquid biopsy, cancer heterogeneity, Oncology and carcinogenesis
Abstract

Previous studies have demonstrated focal but limited molecular similarities between circulating tumor cells (CTCs) and biopsies using isolated genetic assays. We hypothesized that molecular similarity between CTCs and tissue exists at the single cell level when characterized by whole genome sequencing (WGS). By combining the NanoVelcro CTC Chip with laser capture microdissection (LCM), we developed a platform for single-CTC WGS. We performed this procedure on CTCs and tissue samples from a patient with advanced prostate cancer who had serial biopsies over the course of his clinical history. We achieved 30X depth and ≥ 95% coverage. Twenty-nine percent of the somatic single nucleotide variations (SSNVs) identified were founder mutations that were also identified in CTCs. In addition, 86% of the clonal mutations identified in CTCs could be traced back to either the primary or metastatic tumors. In this patient, we identified structural variations (SVs) including an intrachromosomal rearrangement in chr3 and an interchromosomal rearrangement between chr13 and chr15. These rearrangements were shared between tumor tissues and CTCs. At the same time, highly heterogeneous short structural variants were discovered in PTEN, RB1, and BRCA2 in all tumor and CTC samples. Using high-quality WGS on single-CTCs, we identified the shared genomic alterations between CTCs and tumor tissues. This approach yielded insight into the heterogeneity of the mutational landscape of SSNVs and SVs. It may be possible to use this approach to study heterogeneity and characterize the biological evolution of a cancer during the course of its natural history.

Published
2015

43. Polyp detection with colonoscopy assisted by the GI Genius artificial intelligence endoscopy module compared with standard colonoscopy in routine colonoscopy practice (COLO-DETECT): a multicentre, open-label, parallel-arm, pragmatic randomised controlled trial

Author

Seager, Alexander, Sharp, Linda, Neilson, Laura J, Brand, Andrew, Hampton, James S, Lee, Tom J W, Evans, Rachel, Vale, Luke, Whelpton, John, Bestwick, Nathania, Rees, Colin J, Cripps, Neil, Greenaway, John, Higham, Andrew, Jacob, John, Murugananthan, Aravinth, Nylander, David, Patel, Panna, Singh, Salil, and Verma, Ajay M

Abstract

Increased polyp detection during colonoscopy is associated with decreased post-colonoscopy colorectal cancer incidence and mortality. The COLO-DETECT trial aimed to assess the clinical effectiveness of the GI Genius intelligent endoscopy module for polyp detection, comparing colonoscopy assisted by GI Genius (computer-aided detection [CADe]-assisted colonoscopy) with standard colonoscopy in routine practice.

Published
2024
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45. 268 Development of FT825/ONO-8250: an off-the-shelf CAR-T cell with preferential HER2 targeting and engineered to enable multi-antigen targeting, improve trafficking, and overcome immunosuppression

Author

Hosking, Martin, primary, Shirinbak, Soheila, additional, Omilusik, Kyla, additional, Chandra, Shilpi, additional, Gentile, Angela, additional, Kennedy, Stephanie, additional, Loter, Lorraine, additional, Ecker, Chris, additional, Brookhouser, Nicholas, additional, Fong, Lauren, additional, Campanati, Loraine, additional, Yuan, Xu, additional, Palomares, Karina, additional, Pan, Yijia, additional, Sikaroodi, Shohreh, additional, Kaneko, Mika K, additional, Maeda, Tatsuo, additional, Nakayama, Daisuke, additional, Rezner, Betsy, additional, Bjordahl, Ryan, additional, Peralta, Eigen, additional, Szabo, Peter, additional, Cooley, Sarah, additional, Chow, Laura, additional, Clarke, Raedun, additional, Abujarour, Ramzey, additional, Lee, Tom, additional, Yamamoto, Susumu, additional, Kato, Yukinari, additional, and Valamehr, Bahram, additional

Published
2023
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48. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Author

Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Taylor-Robinson, Simon, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, IM, Bishop, Rebecca, Davies, Mervyn, Jones, Rebecca, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Bathgate, Andrew, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Thorburn, Douglas, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Invernizzi, Pietro, Carbone, Marco, Cristoferi, Laura, Bonato, Giulia, Malinverno, Federica, Bernuzzi, Francesca, Alvaro, Domenico, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Muratori, Luigi, Azzaroli, Francesco, Floreani, Annarosa, Galli, Andrea, Tarocchi, Mirko, Giannini, Edoardo, Miele, Luca, Gasbarrini, Antonio, Grieco, Antonio, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Marra, Fabio, Marzioni, Marco, Maroni, Luca, Rigamonti, Cristina, Zuin, Massimo, Battezzati, Pier Maria, Picciotto, Antonino, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Neuberger, James M, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Sampaziotis, Fotios, Gaudio, Eugenio, Ronca, Vincenzo, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, and Mells, George F

Published
2018
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49. A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology

Author

Phillips, Blaine W., Schlage, Walter K., Titz, Bjoern, Kogel, Ulrike, Sciuscio, Davide, Martin, Florian, Leroy, Patrice, Vuillaume, Gregory, Krishnan, Subash, Lee, Tom, Veljkovic, Emilija, Elamin, Ashraf, Merg, Celine, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, and Vanscheeuwijck, Patrick

Published
2018
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