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711 results on '"Lee, Yun Kyung"'

23. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.

Author

Cekanaviciute, Egle, Yoo, Bryan B, Runia, Tessel F, Debelius, Justine W, Singh, Sneha, Nelson, Charlotte A, Kanner, Rachel, Bencosme, Yadira, Lee, Yun Kyung, Hauser, Stephen L, Crabtree-Hartman, Elizabeth, Sand, Ilana Katz, Gacias, Mar, Zhu, Yunjiao, Casaccia, Patrizia, Cree, Bruce AC, Knight, Rob, Mazmanian, Sarkis K, and Baranzini, Sergio E

Subjects
Leukocytes, Mononuclear, T-Lymphocytes, Cells, Cultured, Animals, Humans, Mice, Multiple Sclerosis, Encephalomyelitis, Autoimmune, Experimental, Disease Models, Animal, Female, Male, T-Lymphocytes, Regulatory, Gastrointestinal Microbiome, autoimmunity, microbiome, multiple sclerosis, Brain Disorders, Neurosciences, Autoimmune Disease, Clinical Research, Prevention, Neurodegenerative, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Aetiology, 5.1 Pharmaceuticals, Inflammatory and immune system, Oral and gastrointestinal, Neurological
Abstract

The gut microbiota regulates T cell functions throughout the body. We hypothesized that intestinal bacteria impact the pathogenesis of multiple sclerosis (MS), an autoimmune disorder of the CNS and thus analyzed the microbiomes of 71 MS patients not undergoing treatment and 71 healthy controls. Although no major shifts in microbial community structure were found, we identified specific bacterial taxa that were significantly associated with MS. Akkermansia muciniphila and Acinetobacter calcoaceticus, both increased in MS patients, induced proinflammatory responses in human peripheral blood mononuclear cells and in monocolonized mice. In contrast, Parabacteroides distasonis, which was reduced in MS patients, stimulated antiinflammatory IL-10-expressing human CD4+CD25+ T cells and IL-10+FoxP3+ Tregs in mice. Finally, microbiota transplants from MS patients into germ-free mice resulted in more severe symptoms of experimental autoimmune encephalomyelitis and reduced proportions of IL-10+ Tregs compared with mice "humanized" with microbiota from healthy controls. This study identifies specific human gut bacteria that regulate adaptive autoimmune responses, suggesting therapeutic targeting of the microbiota as a treatment for MS.

Published
2017

24. Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes

Author

Kang, Hyeon-Ji, Min, Byong-Keol, Choi, Won-Il, Jeon, Jae-Han, Kim, Dong Wook, Park, Sungmi, Lee, Yun-Kyung, Kim, Hwa-jin, Byeon, Ju-Eun, Go, Younghoon, Ham, Hye Jin, Jeon, Yong Hyun, Kim, Mi-Jin, Lee, Jung Yi, Wende, Adam R., Choi, Sung Hee, Harris, Robert A., and Lee, In-Kyu

Published
2021
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32. Optically Triggered Emergent Mesostructures in Monolayer WS2

Author

Leem, Young-Chul, primary, Fang, Zhenyao, additional, Lee, Yun-Kyung, additional, Kim, Na-Yeong, additional, Kakekhani, Arvin, additional, Liu, Wenjing, additional, Cho, Sung-Pyo, additional, Kim, Cheolsu, additional, Wang, Yuhui, additional, Ji, Zhurun, additional, Patra, Abhirup, additional, Kronik, Leeor, additional, Rappe, Andrew M., additional, Yim, Sang-Youp, additional, and Agarwal, Ritesh, additional

Published
2024
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45. Importance of Bilateral Hip Assessments in Unilateral Lower-Limb Amputees: A Retrospective Review Involving Older Veterans.

Author

Jin, Seong, An, Chi Hwan, Jeong, Ho Yong, Choi, Woohwa, Hong, Sun-Won, Song, Hoon Ki, Kim, Hyun Sung, Lee, Yun Kyung, Kang, Hyo Jung, Ahn, Dong-young, and Yang, Hea-Eun

Subjects
BONE density, DUAL-energy X-ray absorptiometry, LUMBAR vertebrae, VETERANS, OSTEOPENIA
Abstract

Background/Objectives: This study aimed to evaluate bone mineral density (BMD) discordance and its implications in veterans with unilateral lower-limb amputation, emphasizing the need for comprehensive hip assessments. Methods: Data were collected from 84 male veterans, and BMD was measured using dual-energy X-ray absorptiometry (DXA) at the lumbar spine, intact hip, and amputated hip. Results: The T-scores for the lumbar spine, intact hip, and amputated hip were −0.27 ± 1.69, −0.25 ± 1.20, and −1.07 ± 1.33, respectively. Osteoporosis and osteopenia were present in 19% and 34.6% of patients, respectively. Osteopenia and osteoporosis were most prevalent in the hips on the amputated side (32.1% and 13.1%, respectively), followed by the lumbar spines (22.6% and 8.3%) and the hips on the intact side (17.9% and 2.4%). BMD discordance between the lumbar spine and hip was found in 47.6% of participants, while discordance between both hips was observed in 39.3%. Transfemoral amputees had significantly lower BMD at the amputated hip compared to transtibial amputees (−2.38 ± 1.72 vs. −0.87 ± 1.16, p < 0.001). Conclusions: Veterans with unilateral lower-limb amputation exhibit a high prevalence of osteoporosis and significant BMD discordance, particularly between both hips. These findings underscore the necessity for bilateral hip assessments to ensure the accurate diagnosis and effective management of osteoporosis in this population. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Bee (Apis mellifera L. 1758) wax restores adipogenesis and lipid accumulation of 3T3‐L1 cells in cancer‐associated cachexia condition.

Author

Jang, Hyun‐Jun, Kim, Hyun‐Yong, Lyu, Ji Hyo, Muthamil, Subramanian, Shin, Ung Cheol, Kim, Hyo Seon, Jeong, Jieun, Chang, Suwhan, Lee, Yun Kyung, and Park, Jun Hong

Subjects
OXYGEN consumption, LIPOLYSIS, HONEYBEES, ADIPOGENESIS, CACHEXIA, MUSCLE mass, BEESWAX
Abstract

Cachexia is associated with various diseases, such as heart disease, infectious disease, and cancer. In particular, cancer‐associated cachexia (CAC) accounts for more than 20% of mortality in cancer patients worldwide. Adipose tissue in CAC is characterized by adipocyte atrophy, mainly due to excessively increased lipolysis and impairment of adipogenesis. CAC is well known for the loss of skeletal muscle mass and/or fat mass. CAC induces severe metabolic alterations, including protein, lipid, and carbohydrate metabolism. The objectives of this study were to evaluate the effects of bee wax (Apis mellifera L. 1758) (BW) extract on adipogenesis, lipolysis, and mitochondrial oxygen consumption through white adipocytes, 3T3‐L1. To achieve this study, cancer‐associated cachexia condition was established by incubation of 3T3‐L1 with colon cancer cell line CT26 cultured media. BW extract recovered the reduced adipogenesis under cachectic conditions in CT26 media. Treatment of BW showed increasing lipid accumulation as well as adipogenic gene expression and its target gene during adipogenesis. The administration of BW to adipocytes could decrease lipolysis. Also, BW could significantly downregulated the mitochondrial fatty acid oxidation‐related genes, oxygen consumption rate, and extracellular acidification rate. Our results suggest that BW could improve metabolic disorders such as CAC through the activation of adipogenesis and inhibition of lipolysis in adipocytes, although we need further validation in vivo CAC model to check the effects of BW extract. Therefore, BW extract supplements could be useful as an alternative medicine to reverse energy imbalances. [ABSTRACT FROM AUTHOR]

Published
2024
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