1. An Early Gestation Plasma Inflammasome in Rural Bangladeshi Women
- Author
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Hyunju Kim, Jacquelyn R. Bedsaul-Fryer, Kerry J. Schulze, Gwen Sincerbeaux, Sarah Baker, Casey M. Rebholz, Lee SF Wu, Joseph Gogain, Lena Cuddeback, James D. Yager, Luigi M. De Luca, Towfida J. Siddiqua, and Keith P. West
- Subjects
proteomics ,inflammation ,pregnancy ,biomarkers ,Microbiology ,QR1-502 - Abstract
Circulating α1-acid glycoprotein (AGP) and C-reactive protein (CRP) are commonly measured to assess inflammation, but these biomarkers fail to reveal the complex molecular biology of inflammation. We mined the maternal plasma proteome to detect proteins that covary with AGP and CRP. In 435 gravida predominantly in ®) with AGP and CRP, quantified by immunoassay. We defined a plasma inflammasome as protein correlates meeting a false discovery rate
- Published
- 2024
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