Search

Your search keyword '"Leeds Metropolitan University"' showing total 625 results
Start Over Author "Leeds Metropolitan University"
625 results on '"Leeds Metropolitan University"'

2. OER for research repositories managers

Author

Nick Sheppard, Laura Skilton, Leeds Metropolitan University, Nick Sheppard, Laura Skilton, and Leeds Metropolitan University

Abstract

In this free RSP webinar, Nick Sheppard (Leeds Met Repository Development Officer) and Laura Skilton (Learning and Teaching Coordinator and Jorum Business Development Manager), will discuss issues on Open Educational Resources (OERs), their collections and the role of the institutional repositories. This webinar may be of interest to librarians and repository managers.

Published
2013

11. The Research Cycle

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

Animation showing a roadmap through the research process journey.

Published
2012

12. Evaluating information

Author

Leeds Metropolitan University, Smith, Susan, Wilson, Jennifer, Leeds Metropolitan University, Smith, Susan, and Wilson, Jennifer

Abstract

Leeds Metropolitan University Library Little Book of Information Skills.

Published
2012

14. Skills For Learning - Reflection Toolkit (2)

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

Animation of potential scenario's and 'what if's ...' in a similar situtation.

Published
2012

18. Skills For Learning - Reflection Toolkit (1)

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

Animation of a dialogue between student and tutor reflecting on interaction in a group seminar situation

Published
2012

22. The Little Book of Information Skills Online Referencing and Plagiarism worksheet 2

Author

Leeds Metropolitan University, Cardiff University Information Services, Smith, Susan, Wilson, Jennifer, Leeds Metropolitan University, Cardiff University Information Services, Smith, Susan, and Wilson, Jennifer

Abstract

The Little Book of Information Skills Online . Referencing and plagiarism. Worksheet 2 - Paraphrasing - good and bad examples.

Published
2012

23. The Little Book of Information Skills Online Referencing and Plagiarism Worksheet 1

Author

Leeds Metropolitan University, Cardiff University Information Services, Smith, Susan, Wilson, Jennifer, Leeds Metropolitan University, Cardiff University Information Services, Smith, Susan, and Wilson, Jennifer

Abstract

The Little Book of Information Skills Online. Referencing and plagiarism. Worksheet 1 - avoiding plagiarism exercise.

Published
2012

24. Stages in the Research Process

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

Stages in the Research Process

Published
2012

25. Carnegie Faculty Group for Equality and Diversity presentation notes

Author

Leeds Metropolitan University, Annette Stride, Leeds Metropolitan University, and Annette Stride

Abstract

Equality and diversity presentation notes to accompany the Carnegie Faculty Group for Equality and Diversity PowerPoint resource for Level 4 students.

Published
2011

26. Children of the state: Reforming the case system. New Labour and corporate parenting

Author

Univeristy of Chester ; Leeds Metropolitan University, Harlow, Elizabeth, Frost, Nick, Univeristy of Chester ; Leeds Metropolitan University, Harlow, Elizabeth, and Frost, Nick

Abstract

This book chapter is not available through ChesterRep., This book chapter discusses the role of the government as corporate patent to children who are unable to live with their birth parents. It describes and offers critical reflection on proposals to improve the education achievement of such children and their relational continuity with social workers.

Published
2011

27. Why do we need enterprise in the curriculum?

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

Three easily confused concepts - Enterprise - having an idea, and taking advantage of the opportunities to make things happen Entrepreneurship - an activity which leads to the creation and management of a new organisation designed to pursue a unique, innovative opportunity (Hindle & Rushworth, 2000) Intrapreneurs are "dreamers who do," those who take hands-on responsibility for creating innovation of any kind within an organization'. (Pinchot 1999) It's not about starting a business - its about developing better students

Published
2010

28. Enquiry into Enterprise - Coventry Workshop flyer

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

Discussion topics will include • What is ‘enterprise’ and why does it matter? • Mapping of enterprise values to EBL principles • The role of EBL in developing enterprenerurship and intrapreneurship • Enterprise across the disciplines • Messiness and complexity – challenges, opportunities, integration and embedding

Published
2010

29. Coaching with a Difference

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

This presentation will attempt to map EBL tutors’ skills and behaviours against those typically associated with ‘coaching’ and will make close reference to student and tutor commentary gathered as part of a funded EBL research project.

Published
2010

30. Enhancing learner engagement in e-learning provision

Author

Théophile Munyangeyo, Leeds Metropolitan University, Théophile Munyangeyo, and Leeds Metropolitan University

Abstract

1756-8781, Many theorists and practitioners in education (Atherton, 2009; Costello, 2003; Tomal, 2003) argue that reflection as it relates to our own teaching practice is profoundly part of the foundation of purposeful learning. Questioning our routine allows us to ask ourselves what really does and does not work when we seek to meet learners’ needs. Reflecting on what we do leads to the evaluation of the effectiveness of our teaching practice, the re-examination of our teaching approaches from the perspective of the learner and basing our professional decisions upon feedback from learners and/or colleagues. By examining the current e-learning provision in languages at Leeds Metropolitan University, this study aims to investigate teachers’ perceptions and students’ attitudes and preferences towards good practice in e-learning. This article reflects on the results of a survey of the Languages Subject Group’s e-learning activities and delivery, which was conducted from November 2008 to April 2009. The survey sought to enhance the understanding of good practice in e-learning provision and barriers that might hinder the effective delivery of web-based learning materials, from both the learner’s and the teacher’s point of view. Although preferences, in this respect, may change over time, making any step to understand the determinants of learners’ engagement in e-learning could challenge some assumptions on the effectiveness of teaching and learning approaches.

Published
2009

31. Practice_Exam_Overseas_Conference

Author

Leeds Metropolitan University and Leeds Metropolitan University

Abstract

40 question practice exam on sets of accounts are for years two and three of the Overseas Conference Company. Although written for the applied technology and finance module within the Tourism and entertainment course it is not topic specific. The questions. There is also a printout of the spreadsheet for year three accounts. You should use the information when answering the questions. The zip file is a Respondus file in WebCT/Vista 4-8 format that can be directly exported to x-stream VLE plus text and rtf versions.

Published
2009

32. The Excess Burden of Cancer in Men in the UK

Author

Alan White, Catherine Thomson, National Cancer Intelligence Network, Cancer Research UK, The Centre for Men’s Health, Leeds Metropolitan University, Alan White, Catherine Thomson, National Cancer Intelligence Network, Cancer Research UK, and The Centre for Men’s Health, Leeds Metropolitan University

Abstract

#ISBN goes here#, In general men are at significantly greater risk than women from nearly all of the common cancers that occur in both sexes (with the exception of breast cancer) (White 2009, Wilkins 2006, DH 2007). This report will consider the current overall burden of cancer among men in the UK, estimated from the latest statistics, and outline the extent of the differences between the sexes. All figures and calculations reported here are based on data extracted from the Cancer Research UK CancerStats web pages extracted in June 2009 (Cancer Research UK, 2009).

Published
2009

33. Editorial

Author

Janet Finlay, Jim Stewart, Leeds Metropolitan University, Janet Finlay, Jim Stewart, and Leeds Metropolitan University

Abstract

1756-8781, This special issue of the Assessment, Learning and Teaching Journal brings together articles on two significant and topical subjects: technology enhanced learning and innovative learning spaces. The environments in which students learn, and the technologies they use while learning, are both critical factors in the quality of their learning experience. Designed well, both can scaffold learning and support innovative and effective practices. Both are focused on enhancing the student experience. Both are about applying advances in understanding learning processes and associated theoretical understanding. They are of course also more closely connected. They may have direct implications for each other. Increasing use of technology may result in less demand and need for space, for example, and when new and innovative learning spaces are being commissioned, the contribution of technology is an important element of the design. So, the two areas are often seen as complementary and considered together when policy-makers and institutions are planning investment in educational facilities. In short, learning spaces can be enhanced by the technologies located in them, technology can make ‘everywhere’ a learning space and, sometimes, the technology even becomes the learning space.

Published
2009

34. Same place – different space?

Author

Stuart Hirst, Leeds Metropolitan University, Stuart Hirst, and Leeds Metropolitan University

Abstract

1756-8781, Having worked at Leeds Met, and its predecessor Polytechnic, since 1980 (and in information technology-related areas) it is interesting to reflect on how the introduction of information technology has impacted on the deployment of staff as academics and administrators and the timetable as experienced by students.

Published
2009

35. The magic bullet: formative assessment with peer and tutor feedback in the VLE

Author

Ollie Jones, Leeds Metropolitan University, Ollie Jones, and Leeds Metropolitan University

Abstract

1756-8781, This paper describes and evaluates the use of a formative assessment activity within Leeds Met’s Virtual Learning Environment (VLE) to provide both peer and tutor feedback during the module on an assessment element prior to the main assignment. The task was also designed to provoke students’ interaction with each other and the VLE itself, and act as a familiarisation with e-tivities that formed another part of the assessment. This concept is aligned with Stages 1 and 2 (‘Access’ and ‘Motivation’) of Salmon’s (2000) five-stage model of online engagement.

Published
2009

36. X-stream assessments: utilising new technology to assess sports marketing students

Author

Angela Green, Colin Mitchell, Leeds Metropolitan University, Angela Green, Colin Mitchell, and Leeds Metropolitan University

Abstract

1756-8781, This paper aims to explore our experiences of implementing e-assessment in a sports marketing module at Leeds Met. It will highlight our successes and challenges, and through this, we hope, add to discussion and research in this area. This paper has been jointly written by the academic member of staff responsible for writing and delivering the content for the module and the technical expert who produced the actual e-assessment using the X-stream platform. We therefore hope that our collaborative activities will provide an insight from both an academic and a technical perspective.

Published
2009

37. Book Review

Author

Karli Wilkinson, Leeds Metropolitan University, Karli Wilkinson, and Leeds Metropolitan University

Abstract

1756-8781, Student Engagement in Higher Education: Theoretical Perspectives and Practical Approaches for Diverse Populations edited by Shaun R. Harper and Stephen John QuayeRoutledge, 2008, 368 pages, £21.99 ISBN 978-0-415-98851-3

Published
2009

38. Missing only the inkwells – or is this truly a learning space fit for the 21st century?

Author

Jayne Mothersdale, Leeds Metropolitan University, Jayne Mothersdale, and Leeds Metropolitan University

Abstract

1756-8781, Amid debate about mass changes in the way that we deliver higher education to the millennials and the ‘digital natives’, and with arguments supporting the view that “the idea of putting a lot of people in a classroom and feeding them information being already a thing of the past” (Heppell, 2007), you may be forgiven for being more than a little confused, at first sight, with what presents in the new ‘state of the art’ Rose Bowl building , the new home for over 5,000 students and 300 staff of the Leeds Business School at Leeds Metropolitan University. Its learning environments include a range of lecture theatres and teaching rooms, student social learning spaces, academic/student meeting offices and a café. The large, light-filled ‘classrooms’ are capable of holding 30 – 60 students, span four floors and are furbished with a mixture of square and oblong tables. Far from being technologically deterministic, they look traditional in format, with the blackboards white and the tables missing only the inkwells!

Published
2009

39. Enriching student experience through access to novel technology

Author

Tony Renshaw, Meg Soosay, Leeds Metropolitan University, Tony Renshaw, Meg Soosay, and Leeds Metropolitan University

Abstract

1756-8781, This paper describes how students on a Level 6 (finalyear undergraduate) Human Computer Interaction (HCI) module were given access to an eye tracker with a view to extending their knowledge of the technologies used in HCI for evaluation purposes. Learning to use this device gives students a distinct advantage in the job market as eye tracking is becoming increasingly accepted as a means of assessing users’ experience by professional usability and design experts. However, the benefits were not all one way. The introduction of the eye tracker also brought about a review of pedagogical benefits of this access in terms of the application of learning theory. Changes in the students’ performance and feedback are examined as indicators of enhanced student experience.

Published
2009

40. When learning spaces become learning homes: applications and implications

Author

Gary Poole, Shane Dawson, Leeds Metropolitan University, Gary Poole, Shane Dawson, and Leeds Metropolitan University

Abstract

1756-8781, If we have learned anything from the extensive discussions and research related to places of learning, it is that not all learning spaces are created equal (Fisher, 2005; Johnson & Lomas, 2005). This field of research suggests that well-designed spaces result in increases in student usage and a corresponding increase in student and teacher satisfaction. Some of these learning spaces are ingeniously designed and are, therefore, adopted by students and teachers with minimal modification. Others are designed with an emphasis on flexibility - the contemporary social demands for personalisation affecting learning space design.

Published
2009

41. “What can students do in here that they can’t do anywhere else?”

Author

Victoria Harte, Jim Stewart, Leeds Metropolitan University, Victoria Harte, Jim Stewart, and Leeds Metropolitan University

Abstract

1756-8781, This article reports on the research findings of an evaluation of the Enterprise Learning Space at Old Broadcasting House (OBH), part of the Institute for Enterprise, a HEFCE-funded Centre for Excellence in Teaching and Learning.

Published
2009

42. Sounds Good: using audio to give assessment feedback

Author

Bob Rotheram, Leeds Metropolitan University, Bob Rotheram, and Leeds Metropolitan University

Abstract

1756-8781, Feedback on student work is a problem in higher education (see, for example, the National Student Survey, 2009). On the one hand, students often complain they get too little, too late, and that they sometimes struggle to read or understand it. On the other hand, staff sometimes grumble that they spend ages assessing students’ assignments, but students are only interested in their mark, so don’t read the feedback. Worse, some don’t even bother to collect it. Could technology help? Some years ago, Rust suggested using audiotape. “While reducing the time you spend, this may actually increase rather than reduce the amount of feedback given … Students frequently say that they get far more information from taped comments, including the tone of one’s voice, than they do from written comments, and they also do not have to try to cope with some of our illegible writing.”

Published
2007

43. Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases: an overview of systematic reviews

Author

Loreto Carmona, Lene Terslev, Michael Doherty, Jenny de la Torre-Aboki, Ingrid Möller Parera, Elena Nikiphorou, Will Uwe Kampen, Raul Castellanos-Moreira, Esperanza Naredo, Maria Antonietta D'Agostino, Francis Berenbaum, Jacqueline Uson, Terence W O'Neill, Sebastian C. Rodriguez-García, Irene A Pitsillidou, Mikael Boesen, Hemant Pandit, V. Vardanyan, Universidad Rey Juan Carlos [Madrid] (URJC), University of Manchester [Manchester], University of Nottingham, UK (UON), Copenhagen University Hospital, Leeds Metropolitan University, Facultat de Medicina [Barcelona], Yerevan State Medical University after Mkhitar Heratsi, Rigshospitalet [Copenhagen], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), King‘s College London, King's College Hospital (KCH), Fondazione 'Policlinico Universitario A. Gemelli' [Rome], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
medicine.medical_specialty, therapeutics, Blinding, Settore MED/16 - REUMATOLOGIA, Intra-Articular, Inflammatory arthritis, Immunology, Psychological intervention, Arthritis, Osteoarthritis, Injections, Injections, Intra-Articular, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Bias, Rheumatoid, medicine, Immunology and Allergy, Humans, Knee, Adverse effect, arthritis, 030203 arthritis & rheumatology, 030222 orthopedics, glucocorticoids, business.industry, Treatments, Osteoarthritis, Knee, medicine.disease, 3. Good health, osteoarthritis, Systematic review, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Rheumatoid arthritis, Physical therapy, Medicine, business, Systematic Reviews as Topic
Abstract

ObjectiveTo summarise the evidence on intra-articular therapies (IAT) to inform the 2020 EULAR recommendations.MethodsAn overview of systematic reviews (SR) including randomised-controlled trials (RCTs) of IAT in adults with arthropathies was performed up to July 2020. Pain, function, and frequency of adverse events were the main efficacy and safety outcomes, respectively. Quality was assessed with the A MeaSurement Tool to Assess Systematic Reviews (AMSTAR)-2 tool.ResultsOf 184 references identified, 16 met the inclusion criteria, and a search of their reference lists identified 16 additional SRs. After quality assessment, 29 were finally included. Of these, 18 focused on knee osteoarthritis (KOA), 6 on hip osteoarthritis (HOA), 3 on shoulder capsulitis (SC), and 3 on rheumatoid arthritis. Overall, hyaluronic acid showed a small effect on pain and function in KOA but not in HOA or shoulder capsulitis. Intra-articular glucocorticoids showed a small effect in pain and function in KOA and function in HOA and SC. Platelet-rich plasma showed benefit in pain and function in KOA but not in HOA. Mesenchymal stem cells behaved similarly. Most SR results were of moderate quality and RCTs included often presented a high risk of bias, mainly due to inadequate blinding and heterogeneous results. All interventions were well tolerated with no clear safety differences.ConclusionsThis overview underlines that most IAT currently used in KOA, HOA, and SC exert small effects and are well tolerated. However, no firm conclusions can be drawn for inflammatory arthritis due to the limited data found.

Published
2021
Full Text
View/download PDF

44. Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Author

Kos, Z., Roblin, E., Kim, R. S., Michiels, S., Gallas, B. D., Chen, W., van de Vijver, K. K., Goel, S., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S., Denkert, C., Loibl, S., Luen, S. J., Bartlett, J. M. S., Savas, P., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kok, M., Horlings, H. M., Madabhushi, A., van der Laak, J., Ciompi, F., Laenkholm, A. -V., Bellolio, E., Gruosso, T., Fox, S. B., Araya, J. C., Floris, G., Hudecek, J., Voorwerk, L., Beck, A. H., Kerner, J., Larsimont, D., Declercq, S., Van den Eynden, G., Pusztai, L., Ehinger, A., Yang, W., Abduljabbar, K., Yuan, Y., Singh, R., Hiley, C., Bakir, M., Lazar, A. J., Naber, S., Wienert, S., Castillo, M., Curigliano, G., Dieci, M. -V., Andre, F., Swanton, C., Reis-Filho, J., Sparano, J., Balslev, E., Chen, I. -C., Stovgaard, E. I. S., Pogue-Geile, K., Blenman, K. R. M., Penault-Llorca, F., Schnitt, S., Lakhani, S. R., Vincent-Salomon, A., Rojo, F., Braybrooke, J. P., Hanna, M. G., Soler-Monso, M. T., Bethmann, D., Castaneda, C. A., Willard-Gallo, K., Sharma, A., Lien, H. -C., Fineberg, S., Thagaard, J., Comerma, L., Gonzalez-Ericsson, P., Brogi, E., Loi, S., Saltz, J., Klaushen, F., Cooper, L., Amgad, M., Moore, D. A., Salgado, R., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Gown, A., Lo, A., Sapino, A., Moreira, A. M., Richardson, A., Vingiani, A., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Garrido-Castro, A. C., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Ballesteroes-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Solinas, C., Drubay, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Perez, E., Elgabry, E. A., Blackley, E. F., Reisenbichler, E., Chmielik, E., Gaire, F., F. -I., Lu, Azmoudeh-Ardalan, F., Peale, F., Hirsch, F. R., Acosta-Haab, G., Farshid, G., Broeckx, G., Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Cree, I., Nederlof, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Weseling, J., Giltnane, J., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Hartman, J., Hainfellner, J., Le Quesne, J., Juco, J. W., van den Berg, J., Sanchez, J., Cucherousset, J., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Sikorska, K., Weber, K., Steele, K. E., Emancipator, K., El Bairi, K., Allison, K. H., Korski, K., Buisseret, L., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Van Seijen, M., Lacroix-Triki, M., Sebastian, M. M., Balancin, M. L., Mathieu, M. -C., van de Vijver, M., Rebelatto, M. C., Piccart, M., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., de Maaker, M., Van Bockstal, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Kirtani, P., Watson, P. H., Jelinic, P., Francis, P. A., Russell, P. A., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Bedri, S., Irshad, S., Liu, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Luz, S., Gevaert, T., D'Alfons, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camaea, V. P., Tong, W., Tran, W. T., Wang, Y., Allory, Y., Husain, Z., Bago-Horvath, Z., Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Odense University Hospital, Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Breast Medical Oncology [Houston], The University of Texas M.D. Anderson Cancer Center [Houston], Helsingborg Hospital, Division of Experimental Therapeutics [Milan, Italy], Département de médecine oncologique [Gustave Roussy], Cancer Research UK Lung Cancer Centre of Excellence [Londres, Royaume-Uni], University College of London [London] (UCL), Memorial Sloane Kettering Cancer Center [New York], Herlev and Gentofte Hospital, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Southern Queensland (USQ), Pharmacogenomics Unit [Paris], Department of Genetics [Paris], Institut Curie [Paris]-Institut Curie [Paris], Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ctr Biomol Struct & Org, University of Maryland [College Park], University of Maryland System-University of Maryland System, The University of Sydney, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Int Immuno-Oncology Biomarker, Graduate School, CCA - Cancer biology and immunology, Pathology, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), German Breast Group (GBG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Gallas, Brandon D [0000-0001-7332-1620], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, W Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Savas, Peter [0000-0001-5999-428X], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], van der Laak, Jeroen [0000-0001-7982-0754], Bellolio, Enrique [0000-0003-0079-5264], Araya, Juan Carlos [0000-0003-3501-8203], Floris, Giuseppe [0000-0003-2391-5425], Hudeček, Jan [0000-0003-1071-5686], Ehinger, Anna [0000-0001-9225-7396], Lazar, Alexander J [0000-0002-6395-4499], Castillo, Miluska [0000-0002-0111-3176], Curigliano, Giuseppe [0000-0003-1781-2518], Sparano, Joseph [0000-0002-9031-2010], Braybrooke, Jeremy P [0000-0003-1943-7360], Hanna, Matthew G [0000-0002-7536-1746], Willard-Gallo, Karen [0000-0002-1150-1295], Sharma, Ashish [0000-0002-1011-6504], Comerma, Laura [0000-0002-0249-4636], Gonzalez-Ericsson, Paula [0000-0002-6292-6963], Loi, Sherene [0000-0001-6137-9171], Cooper, Lee [0000-0002-3504-4965], Apollo - University of Cambridge Repository, Research Programs Unit, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center, Department of Oncology, Medicum, Gallas, Brandon D. [0000-0001-7332-1620], van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Symmans, W. Fraser [0000-0002-1526-184X], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Lazar, Alexander J. [0000-0002-6395-4499], Braybrooke, Jeremy P. [0000-0003-1943-7360], and Hanna, Matthew G. [0000-0002-7536-1746]

Subjects
Oncology, [SDV]Life Sciences [q-bio], THERAPY, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Prognostic markers, 0302 clinical medicine, Breast cancer, Medicine and Health Sciences, Pharmacology (medical), Lymphocytes, Stromal tumor, health care economics and organizations, 0303 health sciences, CHEMOTHERAPY, Sciences bio-médicales et agricoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], PROGNOSTIC VALUE, Clinical Practice, 030220 oncology & carcinogenesis, Educational resources, Immunosurveillance, medicine.medical_specialty, 3122 Cancers, [SDV.CAN]Life Sciences [q-bio]/Cancer, IMMUNITY, lcsh:RC254-282, Article, Limfòcits, Càncer de mama, 03 medical and health sciences, Gastrointestinal cancer, SDG 3 - Good Health and Well-being, Internal medicine, 692/53/2422, medicine, Radiology, Nuclear Medicine and imaging, Càncer gastrointestinal, 030304 developmental biology, Predictive biomarker, Tumor-infiltrating lymphocytes, business.industry, Médecine pathologie humaine, medicine.disease, Cancérologie, Human medicine, business, SYSTEM, 631/67/580/1884
Abstract

Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls., info:eu-repo/semantics/published

Published
2020
Full Text
View/download PDF

45. Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue

Author

Richard Marais, Andrew Furness, Thomas B.K. Watkins, Maise Al-Bakir, Dionysis Papadatos-Pastos, Maryam Razaq, Mairead McKenzie, Lisa Pickering, Peter Ellery, Jonathan Ledermann, Andrew V. Biankin, Richard J. Gilbertson, Peter Cockcroft, Mary Mangwende, Sophie Ward, Mary Falzon, Cristina Naceur-Lombardelli, Carlos Caldas, Karla Pearce, Jacqui Shaw, Salma Kadiri, Lars Dyrskjøt, Mark Linch, Daniel Burgess, Nelson Alexander, Christian H. Ottensmeier, Kevin G. Blyth, Lisa L. Gallegos, Rodelaine Wilson, Hayley Bridger, Fiona H Blackhall, Peter J. Parker, Charles Swanton, Allan Hackshaw, Gert Attard, Gordon Stamp, Dean A. Fennell, Debra H. Josephs, Andrew P. Robinson, Kim Edmonds, Tina Mackay, Mita Afroza Akther, Miriam Mitchison, Sam M. Janes, Giorgia Trevisan, Adrienne M. Flanagan, Alison Cluroe, Henning Walczak, Stuart Horswell, Lena Karapagniotou, Simon Tavaré, Sarah Sarker, Teresa Marafioti, Matt Krebs, Anna Green, Philippe Lamy, Reena Khiroya, Samantha M. Hill, Andrew Tutt, Ashish Chandra, Selvaraju Veeriah, Faye Gishen, Lisa Thompson, Sarah Vaughan, Stacey Stanislaw, Kevin Litchfield, Colin Watts, Caroline Dive, Zayd Tippu, Ron Sinclair, Merche Jimenez-Linan, Lavinia Spain, Lizi Manzano, Zoe Rhodes, Caroline Stirling, Elena Provenzano, Andrew Rowan, Katey S. S. Enfield, Vasiliki Michalarea, Nahid Sheikh, Antonia Toncheva, Charlotte Ferris, James Spicer, Kai-Keen Shiu, Aida Murra, Gerald Langman, Scott Thomas Colville Shepherd, Nicholas McGranahan, Fabio Gomes, Daniel Hochhauser, Hang Xu, Sergio A. Quezada, James Larkin, Siow Ming Lee, Chi-wah Lok, Massimo Loda, Gary Middleton, Hollie Bancroft, Jo Dransfield, David Moore, Jennifer Thomas, Rebecca C. Fitzgerald, Peter Colloby, Annika Fendler, Emma Beddowes, Ultan McDermott, Christopher Abbosh, Uzma Asghar, Martin Forster, John Le Quesne, Katherine F. Leith, Paddy Stone, Bernard Olisemeke, Bruce Tanchel, Laura Farrelly, Grant D. Stewart, Justine Korteweg, Sanjay Jogai, Nnenna Kanu, Desiree Schnidrig, Heidi Rosenbaum, Elaine Borg, Mat Carter, Anthony J. Chalmers, Andrew C. Kidd, Alexandre Harlé, Ula Mahadeva, Crispin T. Hiley, Fiona Byrne, Heather Shaw, Mariam Jamal-Hanjani, Karin A. Oien, Ian Proctor, Joanne Webb, Sioban Fraser, Sarah Howlett, Ruby Stewart, Peter Van Loo, Nadia Yousaf, Tanya Ahmad, Martin Collard, Sanjay Popat, James D. Brenton, Sarah Rudman, Lewis Au, David G. Harrison, Elias Pintus, Patricia Roxburgh, Olivia Curtis, Ben Deakin, Ariana Huebner, Debra Enting, Simranpreet Summan, S. Baijal, Iver Nordentoft, Carol Jones, Haixi Yan, Sebastian Brandner, Tariq Enver, Lara-Rose Iredale, Yvonne Summers, Babu Naidu, Abby Sharp, Stephen Hazell, Aoune Barhoumi, Emma Nye, Robert E. Hynds, Sharmistha Ghosh, Emilia L. Lim, Ben Shum, Nikki Hunter, John Bridgewater, Eleanor Carlyle, Stephan Beck, Nicolai Juul Birkbak, Steve Hazell, Samra Turajlic, Amy Kerr, Ian Tomlinson, Adrian Tookman, Litchfield, Kevin [0000-0002-3725-0914], Birkbak, Nicolai J [0000-0003-1613-9587], Nordentoft, Iver [0000-0003-4856-4086], Dyrskjøt, Lars [0000-0001-7061-9851], Apollo - University of Cambridge Repository, Division of genetics and epidemiology, The institute of cancer research [London], The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford [Oxford], Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), The Royal Marsden, University of Arizona, University of Western Ontario, Physic and Astronomy Department, University of Western Ontario (UWO), Center for Biological Sequence Analysis [Lyngby], Technical University of Denmark [Lyngby] (DTU), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Aarhus University Hospital, Cancer Research UK Lung Cancer Centre of Excellence [Londres, Royaume-Uni], University College of London [London] (UCL), Comprehensive Cancer Center, UCL Cancer Institute [University College London], The Wellcome Trust Sanger Institute [Cambridge], Research Department of Pathology, Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Department of histopathology, University College Hospital, Mammalian Genetics Laboratory, Centre for Research on Adaptive Nanostructures and Nanodevices, Trinity College Dublin, Cancer Research UK London Research Institute, Guy's and St Thomas' Hospital [London], Breakthrough Breast Cancer Centre, London Institute of Cancer, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, University of Cambridge [UK] (CAM), Cancer Division [Sydney, Australia] (The Kinghorn Cancer Centre), Garvan Institute of Medical Research [Sydney, Australia], Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, University of Leicester, Experimental Cancer Medicine Centre, University of Southampton-Faculty of Medicine, Moses, Wittemyer, Harrison and Woodruff, P.C., University of Oxford, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), and Garvan Institute of medical research

Subjects
0301 basic medicine, tumor sequencing, medicine.medical_specialty, Sampling protocol, tumor mutational burden, tumor sampling, Lung Neoplasms, molecular profiling, Biopsy, homogenization, Tissue sample, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, medicine, Biomarkers, Tumor, Humans, Solid tumor, lcsh:QH301-705.5, Representative sampling, medicine.diagnostic_test, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Clonal structure, biomarkers, High-Throughput Nucleotide Sequencing, Tumor tissue, tumor hetereogeneity, Tumor Burden, 030104 developmental biology, lcsh:Biology (General), representative sampling, Urinary Bladder Neoplasms, Mutation, Radiology, 030217 neurology & neurosurgery
Abstract

International audience; Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias isinherent in current methodologies. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mmbiopsy), which becomes grossly under-powered as tumor volume scales. Here, we demonstrate representative sequencing (Rep-Seq) as a new method to achieve unbiased tumor tissue sampling. Rep-Seq uses fixed residual tumor material, which is homogenized and subjected to next-generation sequencing. Analysis of intratumor tumor mutation burden (TMB) variability shows a high level of misclassification using current single-biopsy methods, with 20% of lung and 52% of bladder tumors having at least one biopsy with high TMB butlow clonal TMB overall. Misclassification rates by contrast are reduced to 2% (lung) and 4% (bladder) when a more representative sampling methodology is used. Rep-Seq offers an improved sampling protocol for tumor profiling, with significant potential for improved clinical utility and more accurate deconvolution of clonal structure.

Published
2020
Full Text
View/download PDF

46. The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice

Author

Gonzalez-Ericsson, Paula, Stovgaard, Elisabeth, Sua, Luz, Reisenbichler, Emily, Kos, Zuzana, Carter, Jodi, Michiels, Stefan, Le Quesne, John, Nielsen, Torsten, Laenkholm, Anne-Vibeke, Fox, Stephen, Adam, Julien, Bartlett, John MS, Rimm, David, Quinn, Cecily, Peeters, Dieter, Dieci, Maria, Vincent-Salomon, Anne, Cree, Ian, Hida, Akira, Balko, Justin, Haynes, Harry, Frahm, Isabel, Acosta-Haab, Gabriela, Balancin, Marcelo, Bellolio, Enrique, Yang, Wentao, Kirtani, Pawan, Sugie, Tomoharu, Ehinger, Anna, Castaneda, Carlos, Kok, Marleen, McArthur, Heather, Siziopikou, Kalliopi, Badve, Sunil, Fineberg, Susan, Gown, Allen, Viale, Giuseppe, Schnitt, Stuart, Pruneri, Giancarlo, Penault-Llorca, Frédérique, Hewitt, Stephen, Thompson, E Aubrey, Allison, Kimberly, Symmans, William, Bellizzi, Andrew, Brogi, Edi, Moore, David, Larsimont, Denis, Dillon, Deborah, Lazar, Alexander, Lien, Huangchun, Goetz, Matthew, Broeckx, Glenn, El Bairi, Khalid, Harbeck, Nadia, Cimino-Mathews, Ashley, Sotiriou, Christos, Adams, Sylvia, Liu, Shi-Wei, Loibl, Sibylle, Chen, I-Chun, Lakhani, Sunil, Juco, Jonathan, Denkert, Carsten, Blackley, Elizabeth, Demaria, Sandra, Leon-Ferre, Roberto, Gluz, Oleg, Zardavas, Dimitrios, Emancipator, Kenneth, Ely, Scott, Loi, Sherene, Salgado, Roberto, Sanders, Melinda, Gonzalez‐Ericsson, Paula, Lænkholm, Anne‐Vibeke, Vincent‐Salomon, Anne, Acosta‐Haab, Gabriela, Penault‐Llorca, Frederique, Cimino‐Mathews, Ashley, Liu, Shi‐wei, Chen, I‐Chun, Leon‐Ferre, Roberto, Int Immuno-Oncology Biomarker Work, Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), University of Leicester, Department of Pathology, Odense University Hospital, Universita degli Studi di Padova, Pharmacogenomics Unit [Paris], Department of Genetics [Paris], Institut Curie [Paris]-Institut Curie [Paris], Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], Helsingborg Hospital, Ctr Biomol Struct & Org, University of Maryland [College Park], University of Maryland System-University of Maryland System, The Netherlands Cancer Institute, Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), European Institute of Oncology [Milan] (ESMO), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), The University of Texas M.D. Anderson Cancer Center [Houston], Université Mohamed 1 Oujda MAROC, Frauenklinik, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), German Breast Group, University of Southern Queensland (USQ), Charité, Institute of Pathology, Translational Tumorpathology Unit, West German Study Group, Breast International Group [Brussels, Belgium] (BIG aisbl), Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Padova = University of Padua (Unipd), Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), and German Breast Group (GBG)

Subjects
0301 basic medicine, Oncology, PD-L1, medicine.medical_specialty, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, Triple Negative Breast Neoplasms, Pembrolizumab, biomarker risk-management, B7-H1 Antigen, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, Lymphocytes, Tumor-Infiltrating, Atezolizumab, Internal medicine, Biomarkers, Tumor, Medicine, Humans, TILs, Triple-negative breast cancer, Tumor marker, Cancer immunology, Risk Management, business.industry, Médecine pathologie humaine, Sciences bio-médicales et agricoles, immunotherapy, medicine.disease, 3. Good health, Clinical trial, Cancérologie, 030104 developmental biology, 030220 oncology & carcinogenesis, Human medicine, Nivolumab, business
Abstract

Immune checkpoint inhibitor therapies targeting PD-1/PD-L1 are now standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic or locally advanced TNBC with PD-L1 expression on immune cells occupying ≥1% of tumor area demonstrated survival benefit with the addition of atezolizumab to nab-paclitaxel. However, concerns regarding variability between immunohistochemical PD-L1 assay performance and inter-reader reproducibility have been raised. High tumor-infiltrating lymphocytes (TILs) have also been associated with response to PD-1/PD-L1 inhibitors in patients with breast cancer. TILs can be easily assessed on hematoxylin and eosin stained slides and have shown reliable inter-reader reproducibility. As an established prognostic factor in early stage TNBC, TILs are soon anticipated to be reported in daily practice in many pathology laboratories worldwide. Since TILs and PD-L1 are parts of an immunological spectrum in breast cancer, we propose the systematic implementation of combined PD-L1 and TIL analyses as a more comprehensive immune-oncological biomarker for patient selection for PD-1/PD-L1 inhibition-based therapy in patients with breast cancer. Although practical and regulatory considerations differ by jurisdiction, the pathology community has the responsibility to patients to implement assays that lead to optimal patient selection. We propose herewith a risk-management framework that may help mitigate the risks of suboptimal patient selection for immuno-therapeutic approaches in clinical trials and daily practice based on combined TILs/PD-L1 assessment in breast cancer. This article is protected by copyright. All rights reserved., info:eu-repo/semantics/published

Published
2020
Full Text
View/download PDF

47. Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Author

Laura Comerma, Marie-Christine Mathieu, Joel H. Saltz, Giancarlo Pruneri, Peter Savas, Shom Goel, Stephan Wienert, Paula I. Gonzalez-Ericsson, Lee Cooper, Sunil R. Lakhani, Stefan Michiels, Pawan Kirtani, Sarah N Dudgeon, Francesco Ciompi, Uday Kurkure, Manu M. Sebastian, Giuseppe Viale, Brandon D. Gallas, Mohamed Amgad, John M. S. Bartlett, Jan Hudecek, Torsten O. Nielsen, Elisabeth Specht Stovgaard, Huang-Chun Lien, Alexander J. Lazar, Johan Hartman, Yinyin Yuan, Rim S. Kim, Jeppe Thagaard, Ashish Sharma, Sylvia Adams, Matthew G. Hanna, Stephen M. Hewitt, Weijie Chen, David L. Rimm, Khalid AbdulJabbar, Sibylle Loibl, Jochen K. Lennerz, I-Chun Chen, Zsuzsanna Bago-Horvath, Mehrnoush Khojasteh, Frédérique Penault-Llorca, Katherine L. Pogue-Geile, Federico Rojo, Marcelo Luiz Balancin, David Moore, Stuart J. Schnitt, Roberto Salgado, Loes F. S. Kooreman, Sherene Loi, Jeremy P Braybrooke, Eva Balslev, Leonie Voorwerk, Sunil S. Badve, Elvire Roblin, Jennifer K. Kerner, Marleen Kok, Andrew H. Beck, Michael Barnes, Jeroen van der Laak, Carsten Denkert, W. Fraser Symmans, Zuzana Kos, Rajendra Singh, Anant Madabhushi, Christos Sotiriou, Sandra Demaria, Hugo M. Horlings, Department of Pathology, Herlev and Gentofte Hospital, The University of Sydney, Charité, Institute of Pathology, Translational Tumorpathology Unit, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Pathologie morphologique, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), European Institute of Oncology [Milan] (ESMO), University of Southern Queensland (USQ), Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Division of Pathology and Laboratory Medicine, Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), University of the Sunshine Coast (USC), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), German Breast Group (GBG), Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR), Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, The Netherlands Cancer Institute, The University of Texas M.D. Anderson Cancer Center [Houston], Medizinische Universität Wien = Medical University of Vienna, Computational Biomedicine Lab (CBL), University of Houston, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), German Breast Group, Medical University of Vienna, Department of Pathology, Amgad, Mohamed [0000-0001-7599-6162], Sharma, Ashish [0000-0002-1011-6504], Savas, Peter [0000-0001-5999-428X], Hudeček, Jan [0000-0003-1071-5686], Braybrooke, Jeremy P [0000-0003-1943-7360], Demaria, Sandra [0000-0003-4426-0499], Comerma, Laura [0000-0002-0249-4636], Badve, Sunil S [0000-0001-8861-9980], Symmans, W Fraser [0000-0002-1526-184X], Gonzalez-Ericsson, Paula [0000-0002-6292-6963], Rimm, David L [0000-0001-5820-4397], Loi, Sherene [0000-0001-6137-9171], Hanna, Matthew G [0000-0002-7536-1746], Lazar, Alexander J [0000-0002-6395-4499], Bago-Horvath, Zsuzsanna [0000-0002-8555-7806], van der Laak, Jeroen AWM [0000-0001-7982-0754], Gallas, Brandon D [0000-0001-7332-1620], Kurkure, Uday [0000-0002-8273-7334], Cooper, Lee AD [0000-0002-3504-4965], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Computer science, [SDV]Life Sciences [q-bio], Review Article, DIGITAL PATHOLOGY, Tumour biomarkers, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Prognostic markers, 0302 clinical medicine, Breast cancer, Ecology,Evolution & Ethology, Visual scoring, Medicine and Health Sciences, Pharmacology (medical), Chemical Biology & High Throughput, Human Biology & Physiology, IN-SITU, Medicinsk bildbehandling, Genome Integrity & Repair, Sciences bio-médicales et agricoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, SOLID TUMORS, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Oncology, 030220 oncology & carcinogenesis, Tumour immunology, TILS, Tumor immunology, Genetics & Genomics, [SDV.CAN]Life Sciences [q-bio]/Cancer, Cancer imaging, lcsh:RC254-282, CLASSIFICATION, 03 medical and health sciences, Signalling & Oncogenes, STANDARDIZED METHOD, QUALITY-CONTROL, SDG 3 - Good Health and Well-being, BREAST-CANCER, Radiology, Nuclear Medicine and imaging, IMAGE-ANALYSIS, Computational & Systems Biology, Tumor-infiltrating lymphocytes, Digital pathology, Médecine pathologie humaine, Tumour Biology, Data science, Biomarker (cell), Cancérologie, Medical Image Processing, 030104 developmental biology, Workflow, T-CELLS
Abstract

Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring., info:eu-repo/semantics/published

Published
2020
Full Text
View/download PDF

48. Opportunities and challenges for an Indonesian forest monitoring network

Author

Fitri Khusyu Aini, Hendra Gunawan, Rodrigo Cámara-Leret, Andes Hamuraby Rozak, Iswan Dunggio, Agustinus Murdjoko, Lan Qie, Liam A. Trethowan, Endah Sulistyawati, Francis Q. Brearley, Muhammad Abdul Qirom, Thomas E. L. Smith, Muhammad Mansur, Relawan Kuswandi, Fabien Garnier, Charlotte E. Wheeler, Sunitha Pangala, Benjamin J. W. Buckley, Prayoto, Tatang Tiryana, Emma Soraya, Haruni Krisnawati, Hesti Lestari Tata, Elena Cantarello, Siti Sundari, Sutomo, Agustinus P. Tampubolon, Nurul Silva Lestari, Asep Sadili, W.C. Adinugroho, Muhammad Abdullah, Ramadhanil, Diah Irawati Dwi Arini, Antun Puspanti, Aswandi, Campbell O. Webb, Satria Oktarita, Istomo, Charlie D. Heatubun, Ismayadi Samsoedin, Tajudin Edy Komar, Alicia Ledo, Zaenal Mutaqien, Manchester Metropolitan University (MMU), Forestry Research and Development Agency (FORDA), Royal Botanic Gardens, University of Aberdeen, Leeds Metropolitan University, Economic History Department - London school of economics and political science (LSE), London School of Economics and Political Science (LSE), Center for International Forestry Research (CIFOR), Consultative Group on International Agricultural Research [CGIAR] (CGIAR), Sumatran Orangutan Society, Indonesian Institute of Sciences (LIPI), University of Papua New Guinea (UPNG), Universitas Gadjah Mada, Bogor Agricultural University - IPB (INDONESIA), University of Edinburgh, Universitas Negeri Semarang (UNNES), Borneo Nature Foundation, Bournemouth University [Poole] (BU), Gorontalo Regency Res & Dev Agcy, Manokwari Environm & Forestry Res & Dev Inst, Lancaster University, Institut Teknologi Bandung (ITB), Indonesian Government, Harvard University [Cambridge], and British Council through the UK Newton Fund

Subjects
0106 biological sciences, Monitoring, GeneralLiterature_INTRODUCTORYANDSURVEY, Tropical forests, [SDV]Life Sciences [q-bio], Forest management, [SDV.BID]Life Sciences [q-bio]/Biodiversity, 010603 evolutionary biology, 01 natural sciences, SD Forestry, Ecosystem, High potential, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Ecology, business.industry, Environmental resource management, Sampling (statistics), Forestry, 15. Life on land, language.human_language, Carbon, Dynamics, Indonesian, Geography, language, Data sharing, business, GE Environmental Sciences, 010606 plant biology & botany, Diversity (business)
Abstract

© 2019, INRA and Springer-Verlag France SAS, part of Springer Nature. Key message: Permanent sampling plots (PSPs) are a powerful and reliable methodology to help our understanding of the diversity and dynamics of tropical forests. Based on the current inventory of PSPs in Indonesia, there is high potential to establish a long-term collaborative forest monitoring network. Whilst there are challenges to initiating such a network, there are also innumerable benefits to help us understand and better conserve these exceptionally diverse ecosystems.

Published
2019
Full Text
View/download PDF

49. Semantic interoperability of knowledge in feature-based CAD models

Author

Behzad Shariat, Parisa Ghodous, Eliane Perna, Samer Abdul-Ghafour, Farzad Khosrowshahi, Service Oriented Computing (SOC), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Université Lumière - Lyon 2 (UL2), Simulation, Analyse et Animation pour la Réalité Augmentée (SAARA), Modélisation Géométrique, Géométrie Algorithmique, Fractales (GeoMod), and Leeds Metropolitan University

Subjects
Information retrieval, business.industry, Computer science, computer.file_format, Ontology (information science), Semantic interoperability, Computer Graphics and Computer-Aided Design, Industrial and Manufacturing Engineering, Computer Science Applications, Semantic similarity, Description logic, New product development, [INFO]Computer Science [cs], Semantic integration, business, Semantic Web, ISO 10303, computer
Abstract

International audience; A major issue in product development is the exchange and sharing of product knowledgeamong many actors. This knowledge includes many concepts such as design history, componentstructure, features, parameters, constraints, and more.Regarding CAD models, most of the current CAD systems provide feature-based design for theconstruction of solid models and to carry, semantically, product information throughout its life cycle. Unfortunately, existing solutions and standards, such as STEP, for exchanging product information, are limited to the process of geometrical data, where semantics assigned to product model are completely lost during the translation process. Moreover, STEP does not provide a sound basis to reason with knowledge.The work described in this paper is part of our approach based on the development of OWL ontologies to preserve semantics associated with product data. In this work, we will focus on the semantic integration of these ontologies by defining axioms and rules. The integration process relies basically on reasoning capabilities provided by description logics in order to recognize automatically additional mappings among ontologies entities. Furthermore, the mapping process is enhanced with a semantic similarity measure to detect similar design features. Similarity measure integrates all aspects of OWL DL language. Thus, similarity functions are defined for each type of entity to involve all the features that make its definition. However, this will enable data analysis, as well as manage and discover implicit relationships among product data based on semantic modeling and reasoning.

Published
2014
Full Text
View/download PDF

50. Construction Sustainability Through Visualisation of Building Operation

Author

Farzad Khosrowshahi, Parisa Ghodous, Leeds Metropolitan University, Service Oriented Computing (SOC), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Université Lumière - Lyon 2 (UL2), and Springer

Subjects
Engineering, Building maintenance, Process (engineering), 020209 energy, Compromise, media_common.quotation_subject, 0211 other engineering and technologies, Scheduling (production processes), 02 engineering and technology, Information Visualisation, Transport engineering, [SPI]Engineering Sciences [physics], Information visualization, 021105 building & construction, 11. Sustainability, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Economic impact analysis, Lighting, media_common, Flooring, business.industry, Just-in-time, Visualization, Sustainability, Risk analysis (engineering), business, Virtual prototyping
Abstract

International audience; The maintenance phase of construction project exerts the biggest influence on project sustainability which is measured in terms of environmental, social and economic impacts. Building maintenance itself is profoundly influenced by decisions at the design phase. Typically, building maintenance programmes are designed using preventative or responsive approaches. While the former have an adverse impact on both the economic and environmental priorities, the responsive methods tend to compromise the interests of the users. It is therefore argued that the just-in-time methodology is the only approach that is capable of producing an optimised and balanced solution to building maintenance scheduling. However, due to its retrospective nature, this method has posed serious practical challenges. On the other hand, with the advent of visualisation technologies and virtual prototyping, we are now capable of making informed decisions about design parameters as well as generating building maintenance scheduling that would facilitate a just-in-time solution. This chapter presents a visual methodology for developing just-in-time solution through visualisation of the degradation of building components. To this end, the chapter presents the overall time-based visualisation model and demonstrates the simulation process for two major building components—the lighting and flooring systems.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results