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3. Oncologie

Author

de Bree, R., van Laer, C., van den Brekel, M. W. M., Leemans, C. R., de Vries, N., editor, Van de Heyning, P. H., editor, and Leemans, C. R., editor

Published
2019
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5. Cost-utility of an eHealth application ‘Oncokompas’ that supports cancer survivors in self-management: results of a randomised controlled trial

Author

van der Hout, A., Jansen, F., van Uden-Kraan, C. F., Coupé, V. M., Holtmaat, K., Nieuwenhuijzen, G. A., Hardillo, J. A., de Jong, R. J. Baatenburg, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., and Verdonck-de Leeuw, I. M.

Published
2021
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11. The impact of the COVID-19 pandemic on health-related quality of life in head and neck cancer survivors:An observational cohort studs

Author

Lissenberg-Witte, B. I., Jansen, F., Baatenburg de Jong, R. J., Lamers, F., Leemans, C. R., Oosting, S. F., Takes, R. P., Verdonck-de Leeuw, I. M., Lissenberg-Witte, B. I., Jansen, F., Baatenburg de Jong, R. J., Lamers, F., Leemans, C. R., Oosting, S. F., Takes, R. P., and Verdonck-de Leeuw, I. M.

Abstract

Objective: To investigate the impact of the COVID-19 pandemic on physical, psychological, and social aspects of health-related quality of life (HRQOL) among head and neck cancer (HNC) survivors. Materials and methods: Prospectively collected data from the NETherlands QUality of life and BIomedical Cohort study in HNC were used. All patients were diagnosed and treated before the COVID-19 pandemic. Patient reported outcome measures (PROMs) collected 24 and 36 months after treatment (M24 and M36) were compared between survivors who completed both assessments before the COVID-19 pandemic and those who completed M24 before but M36 during the pandemic. Personal, clinical, physical, psychological, social, and lifestyle characteristics of the survivors assessed at baseline or M24 were investigated as potential effect modifiers. Results: In total, 318 HNC survivors were included, of which 199 completed both M24 and M36 before the COVID-19 pandemic and 119 completed M24 before but M36 during the pandemic. Changes in HRQOL between 24 and 36 months follow-up did not differ between the two groups for any of the PROMs. Nevertheless, in some subgroups of HNC survivors the COVID-19 pandemic negatively affected the course of HRQOL for several PROMs while it positively affected the course of HRQOL for other PROMs. Conclusions: The COVID-19 pandemic did not affect HRQOL in HNC survivors in general, but some subgroups were affected in a positive and others in a negative way.

Published
2023

14. Phase III study assessing the best of radiotherapy compared to the best of surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0-N1 oropharyngeal, supraglottic carcinoma and with T1, N0 hypopharyngeal carcinoma

Author

Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., Gregoire, V., Simon, C., Lefevre, C. Fortpied, Govaerts, A-S., Raveloarivahy, T., Bourhis, J., Evans, M., Klussmann, J. P., Leemans, C. R., Hunter, K. D., Singer, S., Nuyts, S., Willemse, E., Ansarin, M., Spriano, G., Golusinski, W., Giger, R., Boehm, A., Lopez, F., and Gregoire, V.

Published
2022

24. Joint Practice Guidelines for Radionuclide Lymphoscintigraphy for Sentinel Node Localization in Oral/Oropharyngeal Squamous Cell Carcinoma

Author

Alkureishi, L. W. T., Burak, Z., Alvarez, J. A., Ballinger, J., Bilde, A., Britten, A. J., Calabrese, L., Chiesa, C., Chiti, A., de Bree, R., Gray, H. W., Hunter, K., Kovacs, A. F., Lassmann, M., Leemans, C. R., Mamelle, G., McGurk, M., Mortensen, J., Poli, T., Shoaib, T., Sloan, P., Sorensen, J. A., Stoeckli, S. J., Thomsen, J. B., Trifiro, G., Werner, J., Ross, G. L., and The European Association of Nuclear Medicine (EANM) Oncology Committee and European Sentinel Node Biopsy Trial (SENT) Committee

Published
2009
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26. The eHealth self-management application ‘Oncokompas’ that supports cancer survivors to improve health-related quality of life and reduce symptoms:which groups benefit most?

Author

van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., Verdonck-de Leeuw, I. M., van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., and Verdonck-de Leeuw, I. M.

Abstract

Background: Oncokompas is a web-based self-management application that supports cancer survivors to monitor their health-related quality of life (HRQOL) and symptoms, and to obtain personalised feedback and tailored options for supportive care. In a large randomised controlled trial among survivors of head and neck cancer, colorectal cancer, and breast cancer and (non-)Hodgkin lymphoma, Oncokompas proved to improve HRQOL, and to reduce several tumour-specific symptoms. Effect sizes were however small, and no effect was observed on the primary outcome patient activation. Therefore, this study aims to explore which subgroups of cancer survivors may especially benefit from Oncokompas. Materials and methods: Cancer survivors (n = 625) were randomly assigned to the intervention group (access to Oncokompas, n = 320) or control group (6 months waiting list, n = 305). Outcome measures were HRQOL, tumour-specific symptoms, and patient activation. Potential moderators included socio-demographic (sex, age, marital status, education, employment), clinical (tumour type, stage, time since diagnosis, treatment modality, comorbidities), and personal factors (self-efficacy, personal control, health literacy, Internet use), and patient activation, mental adjustment to cancer, HRQOL, symptoms, and need for supportive care, measured at baseline. Linear mixed models were performed to investigate potential moderators. Results: The intervention effect on HRQOL was the largest among cancer survivors with low to moderate self-efficacy, and among those with high personal control and those with high health literacy scores. Cancer survivors with higher baseline symptom scores benefitted more on head and neck (pain in the mouth, social eating, swallowing, coughing, trismus), and colorectal cancer (weight) specific symptoms. Discussion: Oncokompas seems most effective in reducing symptoms in head and neck cancer and colorectal cancer survivors who report a higher burden of tumour-specific sym

Published
2021

27. Reasons for not reaching or using web-based self-management applications, and the use and evaluation of Oncokompas among cancer survivors, in the context of a randomised controlled trial

Author

Hout, A. van der, van Uden-Kraan, C. F., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Jong, R. J. Baatenburg de, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., Brekel, M. W. M. van den, Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbosq, I., Broek, W. T. van den, de Brees, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstrab, J. M., Cuijpers, P., Poll-Franse, L. V. van de, Leeuw, I. M. Verdonck-de, Hout, A. van der, van Uden-Kraan, C. F., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., Nieuwenhuijzen, G. A. P., Hardillo, J. A., Jong, R. J. Baatenburg de, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., Brekel, M. W. M. van den, Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbosq, I., Broek, W. T. van den, de Brees, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstrab, J. M., Cuijpers, P., Poll-Franse, L. V. van de, and Leeuw, I. M. Verdonck-de

Abstract

Introduction: The web-based self-management application Oncokompas was developed to support cancer survi-vors to monitor health-related quality of life and symptoms (Measure) and to provide tailored information (Learn) and supportive care options (Act). In a previously reported randomised controlled trial (RCT), 68% of 655 recruited survivors were eligible, and of those 45% participated in the RCT. Among participants of the RCT that were randomised to the intervention group, 52% used Oncokompas as intended. The aim of this study was to explore reasons for not participating in the RCT, and reasons for not using Oncokompas among non-users, and the use and evaluation of Oncokompas among users.

Published
2021

28. The eHealth self-management application 'Oncokompas' that supports cancer survivors to improve health-related quality of life and reduce symptoms: Which groups benefit most?

Author

van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B., Van Uden-Kraan, C. F., Nieuwenhuijzen, G. A. P., Hardillo, J. A., de Jong, R. J. Baatenburg, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, null, van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstra, J. M., Cuijpersa, P., Van De Poll-Franse, L. V., Verdonck-de Leeuw, I. M., van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B., Van Uden-Kraan, C. F., Nieuwenhuijzen, G. A. P., Hardillo, J. A., de Jong, R. J. Baatenburg, Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J. E., Bosscha, K., van den Brekel, M. W. M., Petersen, F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, null, van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E. J., Leemans, C. R., Zijlstra, J. M., Cuijpersa, P., Van De Poll-Franse, L. V., and Verdonck-de Leeuw, I. M.

Abstract

BackgroundOncokompas is a web-based self-management application that supports cancer survivors to monitor their health-related quality of life (HRQOL) and symptoms, and to obtain personalised feedback and tailored options for supportive care. In a large randomised controlled trial among survivors of head and neck cancer, colorectal cancer, and breast cancer and (non-)Hodgkin lymphoma, Oncokompas proved to improve HRQOL, and to reduce several tumour-specific symptoms. Effect sizes were however small, and no effect was observed on the primary outcome patient activation. Therefore, this study aims to explore which subgroups of cancer survivors may especially benefit from Oncokompas.Materials and methodsCancer survivors (n = 625) were randomly assigned to the intervention group (access to Oncokompas, n = 320) or control group (6 months waiting list, n = 305). Outcome measures were HRQOL, tumour-specific symptoms, and patient activation. Potential moderators included socio-demographic (sex, age, marital status, education, employment), clinical (tumour type, stage, time since diagnosis, treatment modality, comorbidities), and personal factors (self-efficacy, personal control, health literacy, Internet use), and patient activation, mental adjustment to cancer, HRQOL, symptoms, and need for supportive care, measured at baseline. Linear mixed models were performed to investigate potential moderators.ResultsThe intervention effect on HRQOL was the largest among cancer survivors with low to moderate self-efficacy, and among those with high personal control and those with high health literacy scores. Cancer survivors with higher baseline symptom scores benefitted more on head and neck (pain in the mouth, social eating, swallowing, coughing, trismus), and colorectal cancer (weight) specific symptoms.DiscussionOncokompas seems most effective in reducing symptoms in head and neck cancer and colorectal cancer survivors who report

Published
2021

29. The eHealth self-management application ‘Oncokompas’ that supports cancer survivors to improve health-related quality of life and reduce symptoms: which groups benefit most?

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., Verdonck-de Leeuw, I. M., MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A., Holtmaat, K., Jansen, F., Lissenberg-Witte, B. I., van Uden-Kraan, C. F., Nieuwenhuijzen, G. A.P., Hardillo, J. A., Baatenburg de Jong, R. J., Tiren-Verbeet, N. L., Sommeijer, D. W., de Heer, K., Schaar, C. G., Sedee, R. J.E., Bosscha, K., van den Brekel, M. W.M., Petersen, J. F., Westerman, M., Honings, J., Takes, R. P., Houtenbos, I., van den Broek, W. T., de Bree, R., Jansen, P., Eerenstein, S. E.J., Leemans, C. R., Zijlstra, J. M., Cuijpers, P., van de Poll-Franse, L. V., and Verdonck-de Leeuw, I. M.

Published
2021

30. Cost-utility of an eHealth application 'Oncokompas' that supports cancer survivors in self-management: results of a randomised controlled trial

Author

CDL Patiëntenzorg KC, Anatomie, ZL Neuromusculaire Ziekten Zorg, MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A, Jansen, F, van Uden-Kraan, C F, Coupé, V M, Holtmaat, K, Nieuwenhuijzen, G A, Hardillo, J A, de Jong, R J Baatenburg, Tiren-Verbeet, N L, Sommeijer, D W, de Heer, K, Schaar, C G, Sedee, R J E, Bosscha, K, van den Brekel, M W M, Petersen, J F, Westerman, M, Honings, J, Takes, R P, Houtenbos, I, van den Broek, W T, de Bree, R, Jansen, P, Eerenstein, S E J, Leemans, C R, Zijlstra, J M, Cuijpers, P, van de Poll-Franse, L V, Verdonck-de Leeuw, I M, CDL Patiëntenzorg KC, Anatomie, ZL Neuromusculaire Ziekten Zorg, MS Hoofd-Hals Chirurgische Oncologie, Cancer, van der Hout, A, Jansen, F, van Uden-Kraan, C F, Coupé, V M, Holtmaat, K, Nieuwenhuijzen, G A, Hardillo, J A, de Jong, R J Baatenburg, Tiren-Verbeet, N L, Sommeijer, D W, de Heer, K, Schaar, C G, Sedee, R J E, Bosscha, K, van den Brekel, M W M, Petersen, J F, Westerman, M, Honings, J, Takes, R P, Houtenbos, I, van den Broek, W T, de Bree, R, Jansen, P, Eerenstein, S E J, Leemans, C R, Zijlstra, J M, Cuijpers, P, van de Poll-Franse, L V, and Verdonck-de Leeuw, I M

Published
2021

37. The eHealth self-management application ‘Oncokompas’ that supports cancer survivors to improve health-related quality of life and reduce symptoms: which groups benefit most?

Author

van der Hout, A., primary, Holtmaat, K., additional, Jansen, F., additional, Lissenberg-Witte, B. I., additional, van Uden-Kraan, C. F., additional, Nieuwenhuijzen, G. A. P., additional, Hardillo, J. A., additional, Baatenburg de Jong, R. J., additional, Tiren-Verbeet, N. L., additional, Sommeijer, D. W., additional, de Heer, K., additional, Schaar, C. G., additional, Sedee, R. J. E., additional, Bosscha, K., additional, van den Brekel, M. W. M., additional, Petersen, J. F., additional, Westerman, M., additional, Honings, J., additional, Takes, R. P., additional, Houtenbos, I., additional, van den Broek, W. T., additional, de Bree, R., additional, Jansen, P., additional, Eerenstein, S. E. J., additional, Leemans, C. R., additional, Zijlstra, J. M., additional, Cuijpers, P., additional, van de Poll-Franse, L. V., additional, and Verdonck-de Leeuw, I. M., additional

Published
2020
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40. Cost-utility of an eHealth application ‘Oncokompas’ that supports cancer survivors in self-management: results of a randomised controlled trial

Author

van der Hout, A., primary, Jansen, F., additional, van Uden-Kraan, C. F., additional, Coupé, V. M., additional, Holtmaat, K., additional, Nieuwenhuijzen, G. A., additional, Hardillo, J. A., additional, de Jong, R. J. Baatenburg, additional, Tiren-Verbeet, N. L., additional, Sommeijer, D. W., additional, de Heer, K., additional, Schaar, C. G., additional, Sedee, R. J. E., additional, Bosscha, K., additional, van den Brekel, M. W. M., additional, Petersen, J. F., additional, Westerman, M., additional, Honings, J., additional, Takes, R. P., additional, Houtenbos, I., additional, van den Broek, W. T., additional, de Bree, R., additional, Jansen, P., additional, Eerenstein, S. E. J., additional, Leemans, C. R., additional, Zijlstra, J. M., additional, Cuijpers, P., additional, van de Poll-Franse, L. V., additional, and Verdonck-de Leeuw, I. M., additional

Published
2020
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45. Correction to:Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: The NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank(BMC Cancer (2019) 19 (765) DOI: 10.1186/s12885-019-5866-z)

Author

Verdonck-de Leeuw, I. M., Jansen, F., Brakenhoff, R. H., Langendijk, J. A., Takes, R., Terhaard, C. H. J., Baatenburg de Jong, R. J., Smit, J. H., Leemans, C. R., Otolaryngology / Head & Neck Surgery, APH - Mental Health, APH - Personalized Medicine, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, AII - Cancer immunology, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and APH - Methodology

Abstract

Following publication of the original article [1], the authors reported the name of R.J. Baatenburg de Jong was incorrectly tagged in the HTML version of the article.

Published
2019
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50. Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

Author

MS Radiotherapie, Cancer, Douma, J A J, Verdonck-de Leeuw, I M, Leemans, C R, Jansen, F, Langendijk, J A, Baatenburg de Jong, R J, Terhaard, C H J, Takes, R P, Chinapaw, M J, Altenburg, T M, Buffart, L M, MS Radiotherapie, Cancer, Douma, J A J, Verdonck-de Leeuw, I M, Leemans, C R, Jansen, F, Langendijk, J A, Baatenburg de Jong, R J, Terhaard, C H J, Takes, R P, Chinapaw, M J, Altenburg, T M, and Buffart, L M

Published
2020

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