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235 results on '"Leenders, K.L."'

2. Identification and validation of a brain glucose metabolism conversion pattern in idiopathic REM Behaviour Disorder

Author

Orso, B., primary, Mattioli, P., additional, Liguori, C., additional, Famà, F., additional, Giorgetti, L., additional, Donniaquio, A., additional, Giberti, A., additional, Vallez Garcia, D., additional, Meles, S.K., additional, Leenders, K.L., additional, Renken, R.J., additional, Placidi, F., additional, Spanetta, M., additional, Chiaravallotti, A., additional, Camedda, R., additional, Schillaci, O., additional, Izzi, F., additional, Mercuri, N.B., additional, Pardini, M., additional, Bauckneht, M., additional, Morbelli, S., additional, Nobili, F., additional, and Arnaldi, D., additional

Published
2022
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11. An application of generalized matrix learning vector quantization in neuroimaging

Author

van-Veen, R. (Rick), Gurvits, V. (Vita), Kogan, R.V. (Rosalie V.), Meles, S.K. (Sanne K.), de-Vries, G. (Gert-Jan), Renken, R.J. (Remco J.), Rodriguez-Oroz, M.C. (María Cruz), Rodriguez-Rojas, R. (Rafael), Arnaldi, D. (Dario), Raffa, S. (Stefano), Jong, B.M. (Bauke M.) de, Leenders, K.L. (Klaus L.), and Biehl, M. (Michael)

Subjects
Scaled sub-profile scaling model principal component analysis (SSM/PCA), [18F]Fluorodeoxyglucose positron emission tomography (FDG-PET), Parkinson’s disease (PD), Generalized matrix learning vector quantization (GMLVQ)
Abstract

Background and objective: Neurodegenerative diseases like Parkinson’s disease often take several years before they can be diagnosed reliably based on clinical grounds. Imaging techniques such as MRI are used to detect anatomical (structural) pathological changes. However, these kinds of changes are usually seen only late in the development. The measurement of functional brain activity by means of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) can provide useful information, but its interpretation is more difficult. The scaled sub-profile model principal component analysis (SSM/PCA) was shown to provide more useful information than other statistical techniques. Our objective is to improve the performance further by combining SSM/PCA and prototype-based generalized matrix learning vector quantization (GMLVQ). Methods: We apply a combination of SSM/PCA and GMLVQ as a classifier. In order to demonstrate the combination’s validity, we analyze FDG-PET data of Parkinson’s disease (PD) patients collected at three different neuroimaging centers in Europe. We determine the diagnostic performance by performing a ten times repeated ten fold cross validation. Additionally, discriminant visualizations of the data are included. The prototypes and relevance of GMLVQ are transformed back to the original voxel space by exploiting the linearity of SSM/PCA. The resulting prototypes and relevance profiles have then been assessed by three neurologists. Results: One important finding is that discriminative visualization can help to identify disease-related properties as well as differences which are due to center-specific factors. Secondly, the neurologist assessed the interpretability of the method and confirmed that prototypes are similar to known activity profiles of PD patients. Conclusion: We have shown that the presented combination of SSM/PCA and GMLVQ can provide useful means to assess and better understand characteristic differences in FDG-PET data from PD patients and HCs. Based on the assessments by medical experts and the results of our computational analysis we conclude that the first steps towards a diagnostic support system have been taken successfully.

Published
2020

12. Abnormal pattern of brain glucose metabolism in parkinson’s disease: replication in three european cohorts

Author

Meles, S.K. (Sanne K.), Renken, R.J. (Remco J.), Pagani, M. (Marco), Teune, L.K. (L. K.), Arnaldi, D. (Dario), Morbelli, S. (Silvia), Nobili, F. (Flavio), van-Laar, T. (Teus), Obeso, J.A. (José A.), Rodriguez-Oroz, M.C. (María Cruz), and Leenders, K.L. (Klaus L.)

Subjects
Metabolic pattern, Parkinson’s disease, Networks, F-FDG PET
Abstract

Rationale In Parkinson’s disease (PD), spatial covariance analysis of 18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a further validation of the PDRP by applying spatial covariance analysis to PD cohorts from the Netherlands (NL), Italy (IT), and Spain (SP). Methods The PDRPNL was previously identified (17 controls, 19 PD) and its expression was determined in 19 healthy controls and 20 PD patients from the Netherlands. The PDRPIT was identified in 20 controls and 20 “de-novo” PD patients from an Italian cohort. A further 24 controls and 18 “de-novo” Italian patients were used for validation. The PDRPSP was identified in 19 controls and 19 PD patients from a Spanish cohort with late-stage PD. Thirty Spanish PD patients were used for validation. Patterns of the three centers were visually compared and then cross-validated. Furthermore, PDRP expression was determined in 8 patients with multiple system atrophy. Results A PDRP could be identified in each cohort. Each PDRP was characterized by relative hypermetabolism in the thalamus, putamen/pallidum, pons, cerebellum, and motor cortex. These changes co-varied with variable degrees of hypometabolism in posterior parietal, occipital, and frontal cortices. Frontal hypometabolism was less pronounced in “de-novo” PD subjects (Italian cohort). Occipital hypometabolism was more pronounced in late-stage PD subjects (Spanish cohort). PDRPIT, PDRPNL, and PDRPSP were significantly expressed in PD patients compared with controls in validation cohorts from the same center (P < 0.0001), and maintained significance on cross-validation (P < 0.005). PDRP expression was absent in MSA.

Published
2020

14. Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation

Author

Hilker, R., Portman, A.T., Voges, J., Staal, M.J., Burghaus, L., van Laar, T., Koulousakis, A., Maguire, R.P., Pruim, J., de Jong, B.M., Herholz, K., Sturm, V., Heiss, W.-D., and Leenders, K.L.

Subjects
Parkinson's disease -- Development and progression, Parkinson's disease -- Care and treatment, Thalamus -- Physiological aspects, Brain stimulation -- Physiological aspects, Health, Psychology and mental health
Published
2005

20. Positron emission tomography of large rock samples using a multiring PET instrument

Author

Maguire, R.P., Missimer, J.H., Emert, F., Townsend, D.W., Dollinger, H., and Leenders, K.L.

Subjects
PET imaging -- Usage, Rocks -- Measurement, Porosity -- Measurement, Business, Electronics, Electronics and electrical industries
Abstract

The technique of positron emission tomography (PET) is well established in the field of medical imaging. Non-medical applications have also been shown to be valuable in the measurement of dynamic chemical processes, specifically in the determination of the characteristics of small rock samples. Since rock is more dense than tissue, the problems of attenuation and scatter are accentuated. However, we are able to show that measurement of porosity in a large rock sample (21.5 cm diameter) is indeed practicable using three-dimensional (3-D) acquisition techniques. Due to multiple scattering of the photons in the rock and the cylindrical symmetry of the experiment, we measured a scatter distribution which is approximately homogeneous, allowing a correction for scattered radiation with a simple method. The problems of determining attenuation coefficients and applying a scatter correction makes absolute quantitation difficult. However, relative changes in porosity within the sample can be measured with a spatial resolution not appreciably different from that in water. Index Terms - PET, rock samples, scatter.

Published
1997

24. Contributors

Author

Abel, Ty W., primary, Aisen, Paul S., additional, Alexander, Gene E., additional, Allman, John M., additional, Anderson, Nicole D., additional, Armstrong, David M., additional, Avis, Nancy E., additional, Baxter, Mark G., additional, Beal, M. Flint, additional, Bouras, Constantin, additional, Browne, Susan E., additional, Buée, Luc, additional, Burkard, Robert, additional, Bussière, Thierry, additional, Cassel, Christine K., additional, Conley, Kevin E., additional, Copinschi, Georges, additional, Cotman, Carl W., additional, Cowen, Tim, additional, Cronin-Golomb, Alice, additional, De Kloet, E. Ron, additional, Delacourte, André, additional, Dhenain, Marc, additional, Dickson, Dennis W., additional, Ding, Dalian, additional, Doty, Richard L., additional, Duan, Huiling, additional, Eddins, Ann Clock, additional, Ek, Kirsten, additional, Erwin, Joseph M., additional, Eshuis, S.A., additional, Frisina, D. Robert, additional, Frisina, Robert D., additional, Furey, Maura L., additional, Gabaldón, A.M., additional, Gannon, Patrick J., additional, Gerhardt, Greg A., additional, Giannakopoulos, Panteleimon, additional, Gilissen, Emmanuel P., additional, Godschalk, Michael, additional, Gold, Gabriel, additional, Grady, Cheryl L., additional, Gruenewald, David A., additional, Guazzelli, Mario, additional, Hansen, Lawrence, additional, Harvey, Philip D., additional, Hays, Nicholas P., additional, Head, Elizabeth, additional, Hebert, Meleik A., additional, Henderson, Donald, additional, Hernandez, M. Rosario, additional, Herrmann, François R., additional, Hof, Patrick R., additional, Horwitz, B.A., additional, Ikonomovic, Milos, additional, Ingram, Donald K., additional, Ison, James R., additional, Joray, Sabine, additional, Joyce, Jeffrey N., additional, Jubrias, Sharon A., additional, Keck, B. Jane, additional, Kolker, Daniel E., additional, Kordower, Jeffrey H., additional, Kövari, Enikö, additional, Kuchel, George A., additional, Kuljis, Rodrigo O., additional, Kuno, Helen, additional, Lakoski, Joan M., additional, LaPolt, Philip S., additional, Leenders, K.L., additional, Leproult, Rachel, additional, Lu, John K.H., additional, Lucassen, Paul J., additional, Magistretti, Pierre J., additional, Marin, Deborah B., additional, Masliah, Eliezer, additional, Matsumoto, Alvin M., additional, Mattson, Mark P., additional, McCoy, Norma L., additional, McDonald, R.B., additional, McFadden, Sandra L., additional, McKeon-O'Malley, Catherine, additional, Michel, Jean-Pierre, additional, Milgram, Norton William, additional, Mishizen, Amanda, additional, Mobbs, Charles V., additional, Mohs, Richard C., additional, Mufson, Elliott J., additional, Mulligan, Thomas, additional, Neufeld, Arthur H., additional, Nimchinsky, Esther A., additional, Pasinetti, Giulio Maria, additional, Pellerin, Luc, additional, Perl, Daniel P., additional, Pietrini, Pietro, additional, Rance, Naomi E., additional, Riggs, Jack E., additional, Roberts, Susan B., additional, Rowe, John W., additional, Salvi, Richard J., additional, Sims, Donald G., additional, Smith, Matthew J., additional, Snell, Karen B., additional, Sonntag, William E., additional, Stanford, John A., additional, Tanzi, Rudolph, additional, Thornton, Phillip L., additional, Tsopelas, Nicholas D., additional, Turek, Fred W., additional, Vallet, Philippe G., additional, Van Cauter, Eve, additional, Vickers, James C., additional, Vogt, Brent A., additional, Vogt, Leslie J., additional, Walton, Joseph P., additional, Willott, James F., additional, and Wise, Phyllis M., additional

Published
2001
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28. Contributors

Author

Abi-Dargham, Anissa, primary, Abrunhosa, A.J., additional, Aigner, T.G., additional, Alpert, Nathaniel M., additional, Andermann, Mark, additional, Anderson, J.R., additional, Andersson, Jesper L. R,, additional, Andreason, Paul, additional, Antonini, A., additional, Arai, Hiroyuki, additional, Ardekani, B.A., additional, Ashburner, John, additional, Ashworth, S., additional, Bailey, D.L., additional, Bánáti, Richard B., additional, Baron, J.C., additional, Barrio, Jorge R., additional, Bauer, R., additional, Beattie, Bradley J., additional, Bergmann, R., additional, Berman, Karen Faith, additional, Berzdorf, A., additional, Besret, L., additional, Blasberg, Ronald G., additional, Bloomfìeld, P.M., additional, Bonab, Ali A., additional, Bowery, A., additional, Brady, F., additional, Brooks, David J., additional, Brühlmeier, M., additional, Brust, P., additional, Budinger, T.F., additional, Byrne, Helen, additional, Carson, Richard E., additional, Chan, G.L. Y., additional, Chatziioannou, Arion, additional, Chefer, Svetlana I., additional, Chen, Chin-Tu, additional, Cherry, Simon R., additional, Cheung, K., additional, Chugani, Diane C., additional, Chugani, Harry T., additional, Cooper, Malcolm, additional, Cunningham, Vincent J., additional, Dagher, Alain, additional, Dahlbom, M., additional, Danielsen, E.H., additional, DaSilva, J.N., additional, Davis, James, additional, de Lima, J.J., additional, DeJesus, O.T., additional, Derenzo, S.E., additional, Dhawan, V., additional, Dogan, A.S., additional, Doudet, D.J., additional, Drevets, W., additional, Duncan, John, additional, Eidelberg, D., additional, Ellmore, Timothy M., additional, Endres, Christopher J., additional, English, C., additional, Esposito, Giuseppe, additional, Evans, Alan C., additional, Farahani, K., additional, Feng, Dagan, additional, Ficaro, Edward P., additional, Fischer, N., additional, Fischman, Alan J., additional, Fiset, Pierre, additional, Frey, Kirk A., additional, Friston, K.J., additional, Füchtner, F., additional, Fukushi, K., additional, Gee, A.D., additional, Ghaemi, M., additional, Ghez, C., additional, Ghilardi, M.F., additional, Gillispie, Steven B., additional, Gjedde, Albert, additional, Graf, R., additional, Grafton, Scott T., additional, Graham, Michael M., additional, Grasby, Paul M., additional, Greenwald, E., additional, Gunn, Roger N., additional, Günther, I., additional, Hansen, L.K., additional, Hansen, Søren B., additional, Heiss, W.-D., additional, Herholz, K., additional, Higuchi, Makoto, additional, Hirani, E., additional, Ho, D., additional, Hoffman, John M., additional, Holden, J.E., additional, Holt, Daniel, additional, Holt, John L., additional, Hommer, Daniel W., additional, Horwitz, Barry, additional, Houle, Sylvain, additional, Huang, Sung-Cheng, additional, Huang, Yiyun, additional, Huesman, R.H., additional, Hume, S.P., additional, Hussey, D., additional, Ibazizene, M., additional, Ido, Tatsuo, additional, Ilmberger, J., additional, Inaba, T., additional, Innis, Robert B., additional, Irie, T., additional, Ishii, Kenji, additional, Ito, K., additional, Itoh, Masatoshi, additional, Iyo, M., additional, Jivan, S., additional, Johannsen, B., additional, Johannsen, Peter, additional, Jones, Terry, additional, Kanno, Iwao, additional, Kapur, S., additional, Kawashima, Ryuta, additional, Kazumata, K., additional, Kilbourn, Michael R., additional, Klein, Denise, additional, Klein, G.J., additional, Koepp, Matthias, additional, Koeppe, Robert A., additional, Kuhl, David E., additional, Kumura, E., additional, Künig, G., additional, Labbé, Claire, additional, Lammertsma, Adriaan A., additional, Landeau, B., additional, Lange, N., additional, Larson, Steve M., additional, Laruelle, Marc, additional, Lau, K.K., additional, Law, I., additional, Leenders, K.L., additional, Lin, K.P., additional, Litt, Harold, additional, Livieratos, L., additional, Lockwood, Geoff, additional, London, Edythe D., additional, Lopresti, Brian, additional, Löttgen, J., additional, Luthra, S.K., additional, Ma, Yilong, additional, MacLeod, A.M., additional, Marenco, S., additional, Marrett, S., additional, Mason, N. Scott, additional, Mathis, Chester A., additional, Matthews, Julian C., additional, Mawlawi, Osama R., additional, Meadors, Ken, additional, Meikle, S.R., additional, Meyer, Ernst, additional, Miller, David H., additional, Miller, M.P., additional, Minoshima, Satoshi, additional, Missimer, J., additional, Moeller, J.R., additional, Moore, A.H., additional, Moran, L., additional, Moreno-Cantú, Jorge J., additional, Morris, Evan D., additional, Morris, H., additional, Morrish, P.K., additional, Morrison, K.S., additional, Moses, W.W., additional, Muzi, Mark, additional, Muzik, Otto, additional, Myers, Ralph, additional, Nagatsuka, S., additional, Namba, H., additional, Nguyen, Thinh B., additional, O'Sullivan, Finbarr, additional, Oakes, T.R., additional, Oda, Keiichi, additional, Ohta, K., additional, Okamura, Nobuyuki, additional, Opacka-Juffry, J., additional, Osman, S., additional, Østergaard, Leif, additional, Paulesu, Eraldo, additional, Paulson, O.B., additional, Paus, T., additional, Pawlik, G., additional, Perevuznik, Jennifer, additional, Petit-Taboué, M.C., additional, Phelps, Michael E., additional, Pietrzyk, U., additional, Price, Julie C., additional, Price, Pat M., additional, Psylla, M., additional, Raffel, D.M., additional, Rakshi, J.S., additional, Raleigh, Michael J., additional, Rawlings, Robert R., additional, Rehm, K., additional, Reulen, H. -J., additional, Reutens, David C., additional, Reutter, B.W., additional, Richardson, Mark, additional, Rio, Daniel, additional, Rottenberg, D.A., additional, Rousset, Olivier G., additional, Ruszkiewicz, James, additional, Ruth, T.J., additional, Ruttimann, Urs E., additional, Sadato, Norihiro, additional, Sasaki, Hidetada, additional, Schaper, K.A., additional, Schumann, P., additional, Schuster, A., additional, Senda, Michio, additional, Shao, Yiping, additional, Shen, Chenggang, additional, Shinotoh, H., additional, Silverman, Robert W., additional, Simpson, N.R., additional, Siu, Wan-Chi, additional, Slates, R., additional, Smith, D.F., additional, Smith, Gwenn S., additional, Snyder, Scott E., additional, Sobesky, J., additional, Søiling, Thomas, additional, Sossi, V., additional, Spinks, Terry J., additional, Steinbach, J., additional, Stout, David B., additional, Strother, S.C., additional, Sudo, Y., additional, Sugita, M., additional, Suhara, T., additional, Suzuki, K., additional, Tatsumi, Itaru, additional, Teng, X., additional, Thiel, A., additional, Thompson, Christopher J., additional, Thorpe, John, additional, Toussaint, P.-J., additional, Toyama, Hinako, additional, Uema, T., additional, Vafaee, M.S., additional, Van Horn, John Darrell, additional, Venkatachalam, T.K., additional, Virador, P.R.G., additional, von Stockhausen, H.-M., additional, Vontobel, P., additional, Vorwieger, G., additional, Votaw, John R., additional, Walter, B., additional, Wienhard, K., additional, Wilson, A.A., additional, Wong, Dean F., additional, Wong, Koon-Pong, additional, Wu, Chi-Ming, additional, Wu, L.C., additional, Yamaki, Atsushi, additional, Yanai, Kazuhiko, additional, Yang, J., additional, Yap, Jeffrey T., additional, Yokoi, Fuji, additional, Young, A.R., additional, Yu, C.L., additional, and Zatorre, Robert J., additional

Published
1998
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33. Contributors

Author

Adam, M., primary, Alpert, Nathaniel M., additional, Anderson, J.R., additional, Andreasen, Nancy C., additional, Antonini, A., additional, Ardekani, Babak A., additional, Arndt, Stephan, additional, Ashburner, John, additional, Ashworth, Sharon, additional, Bailey, Dale L., additional, Baker, E., additional, Barnes, D.G., additional, Bench, C., additional, Bendriem, B., additional, Berdichevsky, D., additional, Biegon, A., additional, Blair, R.C., additional, Blomqvist, G., additional, Bloomfield, Peter M., additional, Ponto, Laura L. Boles, additional, Brakeman, Paul, additional, Braun, Michael, additional, Brooks, David J., additional, Brown, C.K., additional, Brown, W.D., additional, Bruckbauer, T., additional, Buckley, K.R., additional, Calonder, C., additional, Campbell, Gregory, additional, Carson, Richard E., additional, Chaly, Thomas, additional, Chan, G. L-Y., additional, Chen, Chin-Tu, additional, Cizadlo, Ted, additional, Cliffe, I.A., additional, Collins, D.L., additional, Cooper, Malcolm, additional, Crivello, F., additional, Crossnoe, M., additional, Cumming, Paul, additional, Cunningham, Vincent J., additional, Czernin, J., additional, Dahlbom, M., additional, Damasio, H., additional, DaSilva, J., additional, Witherspoon, Margaret E. Daube-, additional, DeJesus, O.T., additional, Delforge, J., additional, Dhawan, Vijay, additional, Dickhoven, S., additional, Diksic, Mirko, additional, Eberl, Stefan, additional, Egan, G.F., additional, Eidelberg, David, additional, Eriksson, Lars, additional, Evans, Alan C., additional, Fink, G.R., additional, Fischman, Alan J., additional, Fisher, Ronald E., additional, Fletcher, A., additional, Fontaine, A., additional, Ford, I., additional, Forse, G., additional, Frackowiak, R.S.J., additional, Frank, R.J., additional, Friston, K.J., additional, Frost, J. James, additional, Frouin, V., additional, Fujita, Hideaki, additional, Fujiwara, Takehiko, additional, Fukuda, H., additional, Fulham, Michael J., additional, Gee, Anthony D., additional, Gillings, N., additional, Gjedde, Albert, additional, Glaser, Robert, additional, Grabowski, T.J., additional, Graf, R., additional, Grafton, S.T., additional, Graham, Michael M., additional, Grasby, P., additional, Gunn, R.N., additional, Günther, I., additional, Hagisawa, S., additional, Haida, A., additional, Halber, M., additional, Hallett, Mark, additional, Hansen, Lars K., additional, Harris, Greg, additional, Haslam, Jane, additional, Hasselbalch, Steen, additional, Hatazawa, Jun, additional, Heiss, W.-D., additional, Herholz, K., additional, Herscovitch, Peter, additional, Herzog, H., additional, Hichwa, Richard D., additional, Hoh, C., additional, Holden, J.E., additional, Holm, Søren, additional, Holmes, A.P., additional, Holmes, C.J., additional, Hooper, Patrick K., additional, Houle, S., additional, Houser, D., additional, Huang, Sung-Cheng, additional, Hume, S.P., additional, Hurtig, Richard R., additional, Hussey, D., additional, Hutton, Brian F., additional, Iacoboni, M., additional, Ido, T., additional, Iida, Hidehiro, additional, Inoue, O., additional, Ishii, Kazunari, additional, Ishikawa, Tatsuya, additional, Itoh, H., additional, Itoh, Masatoshi, additional, Iwata, R., additional, Jadali, F., additional, Jagust, W., additional, Jivan, S., additional, Joliot, M., additional, Jones, A.K.P., additional, Jones, C., additional, Jones, Terry, additional, Kanno, Iwao, additional, Kao, Chien-Min, additional, Kapur, S., additional, Karbe, H., additional, Kessler, J., additional, Kilbourn, Michael R., additional, Kimura, Yuichi, additional, Kinahan, P.E., additional, Knorr, U., additional, Kobayashi, K., additional, Kops, E. Rota, additional, Kosugi, Yukio, additional, Kruger, Mark, additional, Kuwabara, Hiroto, additional, Lammertsma, Adriaan A., additional, Laurier, L., additional, Law, Ian, additional, Leenders, K.L., additional, Legg, B., additional, Levin, Z., additional, Lin, Kang-Ping, additional, Links, Jonathan M., additional, Lipinski, B., additional, Lopresti, B.J., additional, Löttgen, J., additional, Luthra, S.K., additional, Ma, Yilong, additional, Maguire, R.P., additional, Mahmood, K., additional, Malizia, Andrea L., additional, Mankoff, David A., additional, Marenco, Stefano, additional, Marrett, S., additional, Mathis, C.A., additional, Matsumura, Y., additional, Mazoyer, B., additional, Mazziotta, John C., additional, McCarron, J.A., additional, Meguro, K., additional, Meikle, Steven R., additional, Mejia, Marco A., additional, Mellet, E., additional, Meltzer, Carolyn Cidis, additional, Meyer, Ernst, additional, Millet, P., additional, Minoshima, S., additional, Mintun, M.A., additional, Missimer, J., additional, Miura, Shuichi, additional, Miyake, M., additional, Momose, Toshimitsu, additional, Mørch, Niels, additional, Morris, Evan D., additional, Morrish, Paul K., additional, Morrison, S., additional, Müller-Gärtner, H.W., additional, Murase, Kenya, additional, Muzi, Mark, additional, Myers, R., additional, Nakamura, Takashi, additional, Nariai, Tadashi, additional, Neelin, P., additional, Nickles, R.J., additional, Nishikawa, Junichi, additional, Nishizawa, Sadahiko, additional, Nutt, D.J., additional, O'Keefe, G.J., additional, O'Leary, Daniel S., additional, O'Sullivan, B.T., additional, O'Sullivan, Finbarr, additional, Oberschelp, W., additional, Ogawa, Toshihide, additional, Ono, S., additional, Osman, S., additional, Patlak, Clifford, additional, Paulson, Olaf B., additional, Pawlik, Gunter, additional, Petit, L., additional, Pietrzyk, U., additional, Pike, V.W., additional, Poline, J.-B., additional, Poole, K., additional, Price, J.C., additional, Psylla, M., additional, Pyzalski, Robert, additional, Rajeswaran, S., additional, Rakshi, James S., additional, Ranicar, Alex, additional, Rauch, Scott L., additional, Remy, P., additional, Reutens, David C., additional, Roberts, Andy, additional, Rosenqvist, G., additional, Rottenberg, D.A., additional, Rousset, Olivier G., additional, Ruth, T.J., additional, Sadato, Norihiro, additional, Samson, Y., additional, Sasaki, H., additional, Sase, Mikiya, additional, Sashin, D., additional, Schaper, K., additional, Schlaug, G., additional, Schnorr, L., additional, Seitz, R.J., additional, Senda, Michio, additional, Shelton, S.E., additional, Shields, Anthony F., additional, Shimosegawa, Eku, additional, Shiraishi, Masahiro, additional, Shrager, Richard, additional, Sidtis, J.J., additional, Simpson, N.R., additional, Smith, D., additional, Smith, Donald F., additional, Snow, B.J., additional, Snyder, Abraham Z., additional, Sossi, V., additional, Spelle, L., additional, Spence, Alexander, additional, Strother, S.C., additional, Stumpf, Martin J., additional, Suganami, Yusuke, additional, Svarer, Claus, additional, Swerdloff, S.J., additional, Syrota, A., additional, Taguchi, A., additional, Talarico, E., additional, Taylor, Chris, additional, Tellman, L., additional, Thiel, A., additional, Danguy, H. J. Tochon-, additional, Toga, Arthur W., additional, Toussaint, P.-J., additional, Townsend, D.W., additional, Toyama, Hinako, additional, Trébossen, R., additional, Tzourio, N., additional, Uchiyama, A., additional, Uemura, Kazuo, additional, Uno, H., additional, Vafaee, M., additional, Vingerhoets, F.J.G., additional, Vontobel, P., additional, Wagner, R., additional, Watabe, Hiroshi, additional, Watkins, G. Leonard, additional, Watson, J.D.G., additional, Wernick, Miles, additional, Wienhard, K., additional, Wilson, A.A., additional, Wilson, S., additional, Wollenweber, Scott D., additional, Wong, Dean F., additional, Woods, Roger P., additional, Worsley, K.J., additional, Yan, Yuchen, additional, Yanai, K., additional, Yang, J., additional, Yap, Jeffrey T., additional, Yu, D.C., additional, Zeien, Gene, additional, Zhou, Y., additional, and Zubieta, Jon Kar, additional

Published
1996
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36. Chapter 83 Neural transplantation in Parkinson's disease: the Swedish experience

Author

Lindvall, O., primary, Rehncrona, S., additional, Brundin, P., additional, Gustavii, B., additional, Åstedt, B., additional, Widner, H., additional, Lindholm, T., additional, Björklund, A., additional, Leenders, K.L., additional, Rothwell, J.C., additional, Frackowiak, R., additional, Marsden, C.D., additional, Johnels, B., additional, Steg, G., additional, Freedman, R., additional, Hoffer, B.J., additional, Seiger, Å., additional, Bygdeman, M., additional, Strömberg, I., additional, and Olson, L., additional

Published
1990
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39. Cerebral blood flow, blood volume and oxygen utilization: normal values and effect of age

Author

Leenders, K.L., Perani, D., Lammertsma, A.A., Heather, J.D., Buckingham, P., Healy, M.J.R., Gibbs, J.M., Wise, R.J.S., Hatazawa, J., Herold, S., Beaney, R.P., Brooks, D.J., Spinks, T., Rhodes, C., Frackowiak, R.S.J., and Jones, T.

Subjects
Regional blood flow -- Measurement, Brain -- Aging, Cerebral circulation -- Demographic aspects, Health
Abstract

Various measurements can be used to study the energy metabolism of the brain; these include regional cerebral blood flow (CBF), oxygen extraction ratio (OER), oxygen utilization (CMRO2), and cerebral blood volume. Several earlier studies of healthy volunteers examined the effect of age on these parameters and sought to establish a range of normal values that would permit comparisons with ill patients, but the results were unclear. Under normal conditions, the CBF is directly related to the brain oxygen and glucose consumption, but the mechanisms responsible for this coupling are not known. A recent study of 34 healthy adults, 22 to 82 years of age, measured brain regional CBF, CMRO2, OER, and CBV using a method called oxygen steady-state inhalation, combined with a brain imaging technique called positron emission tomography (PET). In support of earlier studies, CBF was directly related CMRO2. OER or the amount of oxygen taken up from the blood was not related to brain CMRO2 or CBF. As expected, CBV was directly related to the CBF. The aging process decreased CMRO2, CBF, and CBV by 0.5 percent per year. The OER either remained the same or else slightly increased by an average of 0.35 percent per year. These results might indicate that neurotransmission, which is the process of how the brain communicates with itself, may decrease with age, but further studies are needed to confirm this. Furthermore, these observations give insight into the processes of normal brains and help researchers understand what happens in diseased brains. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

40. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Author

Moss, Davina J Hensman, primary, Pardiñas, Antonio F, additional, Langbehn, Douglas, additional, Lo, Kitty, additional, Leavitt, Blair R, additional, Roos, Raymund, additional, Durr, Alexandra, additional, Mead, Simon, additional, Holmans, Peter, additional, Jones, Lesley, additional, Tabrizi, Sarah J, additional, Coleman, A, additional, Santos, R Dar, additional, Decolongon, J, additional, Sturrock, A, additional, Bardinet, E, additional, Ret, C Jauff, additional, Justo, D, additional, Lehericy, S, additional, Marelli, C, additional, Nigaud, K, additional, Valabrègue, R, additional, van den Bogaard, SJA, additional, Dumas, E M, additional, van der Grond, J, additional, t'Hart, EP, additional, Jurgens, C, additional, Witjes-Ane, M-N, additional, Arran, N, additional, Callaghan, J, additional, Stopford, C, additional, Frost, C, additional, Jones, R, additional, Hobbs, N, additional, Lahiri, N, additional, Ordidge, R, additional, Owen, G, additional, Pepple, T, additional, Read, J, additional, Say, M, additional, Wild, E, additional, Patel, A, additional, Fox, N C, additional, Gibbard, C, additional, Malone, I, additional, Crawford, H, additional, Whitehead, D, additional, Keenan, S, additional, Cash, D M, additional, Berna, C, additional, Bechtel, N, additional, Bohlen, S, additional, Man, A Hoff, additional, Kraus, P, additional, Axelson, E, additional, Wang, C, additional, Acharya, T, additional, Lee, S, additional, Monaco, W, additional, Campbell, C, additional, Queller, S, additional, Whitlock, K, additional, Campbell, M, additional, Frajman, E, additional, Milchman, C, additional, O'Regan, A, additional, Labuschagne, I, additional, Stout, J, additional, Landwehrmeyer, B, additional, Craufurd, D, additional, Scahill, R, additional, Hicks, S, additional, Kennard, C, additional, Johnson, H, additional, Tobin, A, additional, Rosas, HD, additional, Reilmann, R, additional, Borowsky, B, additional, Pourchot, C, additional, Andrews, S C, additional, Bachoud-Lévi, Anne-Catherine, additional, Bentivoglio, Anna Rita, additional, Biunno, Ida, additional, Bonelli, Raphael, additional, Burgunder, Jean-Marc, additional, Dunnett, Stephen, additional, Ferreira, Joaquim, additional, Handley, Olivia, additional, Heiberg, Arvid, additional, Illmann, Torsten, additional, Landwehrmeyer, G. Bernhard, additional, Levey, Jamie, additional, Ramos-Arroyo, Maria A., additional, Nielsen, Jørgen, additional, Koivisto, Susana Pro, additional, Päivärinta, Markku, additional, Roos, Raymund A.C., additional, Sebastián, A Rojo, additional, Tabrizi, Sarah, additional, Vandenberghe, Wim, additional, Verellen-Dumoulin, Christine, additional, Uhrova, Tereza, additional, Wahlström, Jan, additional, Zaremba, Jacek, additional, Baake, Verena, additional, Barth, Katrin, additional, Garde, Monica Bascuñana, additional, Betz, Sabrina, additional, Bos, Reineke, additional, Callaghan, Jenny, additional, Come, Adrien, additional, Guedes, Leonor Correia, additional, Ecker, Daniel, additional, Finisterra, Ana Maria, additional, Fullam, Ruth, additional, Gilling, Mette, additional, Gustafsson, Lena, additional, Handley, Olivia J, additional, Hvalstedt, Carina, additional, Held, Christine, additional, Koppers, Kerstin, additional, Lamanna, Claudia, additional, Laurà, Matilde, additional, Descals, Asunción Martínez, additional, Martinez-Horta, Saül, additional, Mestre, Tiago, additional, Minster, Sara, additional, Monza, Daniela, additional, Mütze, Lisanne, additional, Oehmen, Martin, additional, Orth, Michael, additional, Padieu, Hélène, additional, Paterski, Laurent, additional, Peppa, Nadia, additional, Di Renzo, Martina, additional, Rialland, Amandine, additional, Røren, Niini, additional, Šašinková, Pavla, additional, Timewell, Erika, additional, Townhill, Jenny, additional, Cubillo, Patricia Trigo, additional, da Silva, Wildson Vieira, additional, van Walsem, Marleen R, additional, Whalstedt, Carina, additional, Witjes-Ané, Marie-Noelle, additional, Witkowski, Grzegorz, additional, Wright, Abigail, additional, Zielonka, Daniel, additional, Zielonka, Eugeniusz, additional, Zinzi, Paola, additional, Bonelli, Raphael M., additional, Lilek, Sabine, additional, Hecht, Karen, additional, Herranhof, Brigitte, additional, Holl, Anna, additional, Kapfhammer, Hans-Peter, additional, Koppitz, Michael, additional, Magnet, Markus, additional, Müller, Nicole, additional, Otti, Daniela, additional, Painold, Annamaria, additional, Reisinger, Karin, additional, Scheibl, Monika, additional, Schöggl, Helmut, additional, Ullah, Jasmin, additional, Braunwarth, Eva-Maria, additional, Brugger, Florian, additional, Buratti, Lisa, additional, Hametner, Eva-Maria, additional, Hepperger, Caroline, additional, Holas, Christiane, additional, Hotter, Anna, additional, Hussl, Anna, additional, Müller, Christoph, additional, Poewe, Werner, additional, Seppi, Klaus, additional, Sprenger, Fabienne, additional, Wenning, Gregor, additional, Boogaerts, Andrea, additional, Calmeyn, Godelinde, additional, Delvaux, Isabelle, additional, Liessens, Dirk, additional, Somers, Nele, additional, Dupuit, Michel, additional, Minet, Cécile, additional, van Paemel, Dominique, additional, Ribaï, Pascale, additional, van Reijen, Dimphna, additional, Klempír, Jirí, additional, Majerová, Veronika, additional, Roth, Jan, additional, Stárková, Irena, additional, Hjermind, Lena E., additional, Jacobsen, Oda, additional, Nielsen, Jørgen E., additional, Larsen, Ida Unmack, additional, Vinther-Jensen, Tua, additional, Hiivola, Heli, additional, Hyppönen, Hannele, additional, Martikainen, Kirsti, additional, Tuuha, Katri, additional, Allain, Philippe, additional, Bonneau, Dominique, additional, Bost, Marie, additional, Gohier, Bénédicte, additional, Guérid, Marie-Anne, additional, Olivier, Audrey, additional, Prundean, Adriana, additional, Scherer-Gagou, Clarisse, additional, Verny, Christophe, additional, Babiloni, Blandine, additional, Debruxelles, Sabrina, additional, Duché, Charlotte, additional, Goizet, Cyril, additional, Jameau, Laetitia, additional, Lafoucrière, Danielle, additional, Spampinato, Umberto, additional, Barthélémy, Rekha, additional, De Bruycker, Christelle, additional, Carette, Maryline Cabaret Anne-Sophie, additional, Defebvre, Eric Decorte Luc, additional, Delliaux, Marie, additional, Delval, Arnaud, additional, Destee, Alain, additional, Dujardin, Kathy, additional, Lemaire, Marie-Hélène, additional, Manouvrier, Sylvie, additional, Peter, Mireille, additional, Plomhouse, Lucie, additional, Sablonnière, Bernard, additional, Simonin, Clémence, additional, Thibault-Tanchou, Stéphanie, additional, Vuillaume, Isabelle, additional, Bellonet, Marcellin, additional, Berrissoul, Hassan, additional, Blin, Stéphanie, additional, Courtin, Françoise, additional, Duru, Cécile, additional, Fasquel, Véronique, additional, Godefroy, Olivier, additional, Krystkowiak, Pierre, additional, Mantaux, Béatrice, additional, Roussel, Martine, additional, Wannepain, Sandrine, additional, Azulay, Jean-Philippe, additional, Delfini, Marie, additional, Eusebio, Alexandre, additional, Fluchere, Frédérique, additional, Mundler, Laura, additional, Anheim, Mathieu, additional, Julié, Celine, additional, Boukbiza, Ouhaid Lagha, additional, Longato, Nadine, additional, Rudolf, Gabrielle, additional, Tranchant, Christine, additional, Zimmermann, Marie-Agathe, additional, Kosinski, Christoph Michael, additional, Milkereit, Eva, additional, Probst, Daniela, additional, Reetz, Kathrin, additional, Sass, Christian, additional, Schiefer, Johannes, additional, Schlangen, Christiane, additional, Werner, Cornelius J., additional, Gelderblom, Harald, additional, Priller, Josef, additional, Prüß, Harald, additional, Spruth, Eike Jakob, additional, Ellrichmann, Gisa, additional, Herrmann, Lennard, additional, Hoffmann, Rainer, additional, Kaminski, Barbara, additional, Kotz, Peter, additional, Prehn, Christian, additional, Saft, Carsten, additional, Lange, Herwig, additional, Maiwald, Robert, additional, Löhle, Matthias, additional, Maass, Antonia, additional, Schmidt, Simone, additional, Bosredon, Cecile, additional, Storch, Alexander, additional, Wolz, Annett, additional, Wolz, Martin, additional, Capetian, Philipp, additional, Lambeck, Johann, additional, Zucker, Birgit, additional, Boelmans, Kai, additional, Ganos, Christos, additional, Heinicke, Walburgis, additional, Hidding, Ute, additional, Lewerenz, Jan, additional, Münchau, Alexander, additional, Schmalfeld, Jenny, additional, Stubbe, Lars, additional, Zittel, Simone, additional, Diercks, Gabriele, additional, Dressler, Dirk, additional, Gorzolla, Heike, additional, Schrader, Christoph, additional, Tacik, Pawel, additional, Ribbat, Michael, additional, Longinus, Bernhard, additional, Bürk, Katrin, additional, Möller, Jens Carsten, additional, Rissling, Ida, additional, Mühlau, Mark, additional, Peinemann, Alexander, additional, Städtler, Michael, additional, Weindl, Adolf, additional, Winkelmann, Juliane, additional, Ziegler, Cornelia, additional, Bechtel, Natalie, additional, Beckmann, Heike, additional, Bohlen, Stefan, additional, Hölzner, Eva, additional, Reilmann, Ralf, additional, Rohm, Stefanie, additional, Rumpf, Silke, additional, Schepers, Sigrun, additional, Weber, Natalia, additional, Dose, Matthias, additional, Leythäuser, Gabriele, additional, Marquard, Ralf, additional, Raab, Tina, additional, Wiedemann, Alexandra, additional, Buck, Andrea, additional, Connemann, Julia, additional, Geitner, Carolin, additional, Kesse, Andrea, additional, Landwehrmeyer, Bernhard, additional, Lang, Christina, additional, Lezius, Franziska, additional, Nepper, Solveig, additional, Niess, Anke, additional, Schneider, Ariane, additional, Schwenk, Daniela, additional, Süßmuth, Sigurd, additional, Trautmann, Sonja, additional, Weydt, Patrick, additional, Cormio, Claudia, additional, Sciruicchio, Vittorio, additional, Serpino, Claudia, additional, de Tommaso, Marina, additional, Capellari, Sabina, additional, Cortelli, Pietro, additional, Galassi, Roberto, additional, Rizzo, Giovanni, additional, Poda, Roberto, additional, Scaglione, Cesa, additional, Bertini, Elisabetta, additional, Ghelli, Elena, additional, Ginestroni, Andrea, additional, Massaro, Francesca, additional, Mechi, Claudia, additional, Paganini, Marco, additional, Piacentini, Silvia, additional, Pradella, Silvia, additional, Romoli, Anna Maria, additional, Sorbi, Sandro, additional, Abbruzzese, Giovanni, additional, di Poggio, Monica Bandettini, additional, Ferrandes, Giovanna, additional, Mandich, Paola, additional, Marchese, Roberta, additional, Albanese, Alberto, additional, Di Bella, Daniela, additional, Castaldo, Anna, additional, Di Donato, Stefano, additional, Gellera, Cinzia, additional, Genitrini, Silvia, additional, Mariotti, Caterina, additional, Nanetti, Lorenzo, additional, Paridi, Dominga, additional, Soliveri, Paola, additional, Tomasello, Chiara, additional, De Michele, Giuseppe, additional, Di Maio, Luigi, additional, Massarelli, Marco, additional, Peluso, Silvio, additional, Roca, Alessandro, additional, Russo, Cinzia Valeria, additional, Salvatore, Elena, additional, Sorrentino, Pierpaolo, additional, Amico, Enrico, additional, Favellato, Mariagrazia, additional, Griguoli, Annamaria, additional, Mazzante, Irene, additional, Petrollini, Martina, additional, Squitieri, Ferdinando, additional, D'Alessio, Barbara, additional, Esposito, Chiara, additional, Bentivoglio, Rita, additional, Frontali, Marina, additional, Guidubaldi, Arianna, additional, Ialongo, Tamara, additional, Jacopini, Gioia, additional, Piano, Carla, additional, Romano, Silvia, additional, Soleti, Francesco, additional, Spadaro, Maria, additional, van Hout, Monique S.E., additional, Verhoeven, Marloes E., additional, van Vugt, Jeroen P.P., additional, de Weert, A. Marit, additional, Bolwijn, J.J.W., additional, Dekker, M., additional, Kremer, B., additional, Leenders, K.L., additional, van Oostrom, J.C.H., additional, van den Bogaard, Simon J.A., additional, Dumas, Eve M., additional, 't Hart, Ellen P., additional, Kremer, Berry, additional, Verstappen, C.C.P., additional, Aaserud, Olaf, additional, C, Jan Frich, additional, Wehus, Ragnhild, additional, Bjørgo, Kathrine, additional, Fannemel, Madeleine, additional, Gørvell, Per F., additional, Lorentzen, Eirin, additional, Retterstøl, Lars, additional, Stokke, Bodil, additional, Bjørnevoll, Inga, additional, Sando, Sigrid Botne, additional, Dziadkiewicz, Artur, additional, Nowak, Malgorzata, additional, Robowski, Piotr, additional, Sitek, Emilia, additional, Slawek, Jaroslaw, additional, Soltan, Witold, additional, Szinwelski, Michal, additional, Blaszcyk, Magdalena, additional, Boczarska-Jedynak, Magdalena, additional, Ciach-Wysocka, Ewelina, additional, Gorzkowska, Agnieszka, additional, Jasinska-Myga, Barbara, additional, Klodowska-Duda, Gabriela, additional, Opala, Gregorz, additional, Stompel, Daniel, additional, Banaszkiewicz, Krzysztof, additional, Bocwinska, Dorota, additional, Bojakowska-Jaremek, Kamila, additional, Dec, Malgorzata, additional, Krawczyk, Malgorzata, additional, Rudzinska, Monika, additional, Szczygiel, Elzbieta, additional, Szczudlik, Andrzej, additional, Wasielewska, Anna, additional, Wójcik, Magdalena, additional, Bryl, Anna, additional, Ciesielska, Anna, additional, Klimberg, Aneta, additional, Marcinkowski, Jerzy, additional, Samara, Husam, additional, Sempolowicz, Justyna, additional, Gogol, Anna, additional, Janik, Piotr, additional, Kwiecinski, Hubert, additional, Jamrozik, Zygmunt, additional, Antczak, Jakub, additional, Jachinska, Katarzyna, additional, Krysa, Wioletta, additional, Rakowicz, Maryla, additional, Richter, Przemyslaw, additional, Rola, Rafal, additional, Ryglewicz, Danuta, additional, Sienkiewicz-Jarosz, Halina, additional, Stepniak, Iwona, additional, Sulek, Anna, additional, Zdzienicka, Elzbieta, additional, Zieora-Jakutowicz, Karolina, additional, Ferreira, Joaquim J, additional, Coelho, Miguel, additional, Mendes, Tiago, additional, Valadas, Anabela, additional, Andrade, Carlos, additional, Gago, Miguel, additional, Garrett, Carolina, additional, Guerra, Maria Rosália, additional, Herrera, Carmen Durán, additional, Garcia, Patrocinio Moreno, additional, Barbera, Miquel Aguilar, additional, Guia, Dolors Badenes, additional, Hernanz, Laura Casas, additional, Catena, Judit López, additional, Ferrer, Pilar Quiléz, additional, Sebastián, Ana Rojo, additional, Carruesco, Gemma Tome, additional, Bas, Jordi, additional, Busquets, Núria, additional, Calopa, Matilde, additional, Robert, Misericordia Floriach, additional, Viladrich, Celia Mareca, additional, Idiago, Jesús Miguel Ruiz, additional, Riballo, Antonio Villa, additional, Cubo, Esther, additional, Polo, Cecilia Gil, additional, Mariscal, Natividad, additional, Rivadeneyra, Perez Jessica, additional, Barrero, Francisco, additional, Morales, Blas, additional, Fenollar, María, additional, García, Rocío García-Ramos, additional, Ortega, Paloma, additional, Villanueva, Clara, additional, Alegre, Javier, additional, Bascuñana, Mónica, additional, Caldentey, Juan Garcia, additional, Ventura, Marta Fatás, additional, Ribas, Guillermo García, additional, de Yébenes, Justo García, additional, Moreno, José Luis López-Sendón, additional, Frech, Fernando Alonso, additional, Ruíz, Pedro J García, additional, Martínez-Descals, Asunción, additional, Guerrero, Rosa, additional, Artiga, María José Saiz, additional, Sánchez, Vicenta, additional, Perea, María Fuensanta Noguera, additional, Fortuna, Lorenza, additional, Manzanares, Salvadora, additional, Reinante, Gema, additional, Torres, María Martirio Antequera, additional, Moreau, Laura Vivancos, additional, González González, Sonia, additional, Guisasola, Luis Menéndez, additional, Salvador, Carlos, additional, Martín, Esther Suaréz San, additional, Ramirez, Inés Legarda, additional, Gorospe, Aranzazú, additional, Lopera, Mónica Rodriguez, additional, Arques, Penelope Navas, additional, Rodríguez, María José Torres, additional, Pastor, Barbara Vives, additional, Gaston, Itziar, additional, Martinez-Jaurrieta, Maria Dolores, additional, Moreno, Jose Manuel Garcia, additional, Lucena, Carolina Mendez, additional, Damas, Fatima, additional, Cortegana, Hermoso Eva Pacheco, additional, Peña, José Chacón, additional, Redondo, Luis, additional, Carrillo, Fátima, additional, Teresa Cáceres, María, additional, Mir, Pablo, additional, Suarez, María José Lama, additional, Vargas-González, Laura, additional, Bosca, Maria E., additional, Brugada, Francisco Castera, additional, Burguera, Juan Andres, additional, Campos, Anabel, additional, Vilaplana, Garcia Carmen Peiró, additional, Berglund, Peter, additional, Constantinescu, Radu, additional, Fredlund, Gunnel, additional, Høsterey-Ugander, Ulrika, additional, Linnsand, Petra, additional, Neleborn-Lingefjärd, Liselotte, additional, Wentzel, Magnus, additional, Loutfi, Ghada, additional, Olofsson, Carina, additional, Stattin, Eva-Lena, additional, Westman, Laila, additional, Wikström, Birgitta, additional, Stebler, Yanik, additional, Kaelin, Alain, additional, Romero, Irene, additional, Schüpbach, Michael, additional, Weber Zaugg, Sabine, additional, Hauer, Maria, additional, Gonzenbach, Roman, additional, Jung, Hans H., additional, Mihaylova, Violeta, additional, Petersen, Jens, additional, Jack, Roisin, additional, Matheson, Kirsty, additional, Miedzybrodzka, Zosia, additional, Rae, Daniela, additional, Simpson, Sheila A, additional, Summers, Fiona, additional, Ure, Alexandra, additional, Vaughan, Vivien, additional, Akhtar, Shahbana, additional, Crooks, Jenny, additional, Curtis, Adrienne, additional, de Souza, Jenny, additional, Piedad, John, additional, Rickards, Hugh, additional, Wright, Jan, additional, Coulthard, Elizabeth, additional, Gethin, Louise, additional, Hayward, Beverley, additional, Sieradzan, Kasia, additional, Armstrong, Matthew, additional, Barker, Roger A., additional, O'Keefe, Deidre, additional, Di Pietro, Anna, additional, Fisher, Kate, additional, Goodman, Anna, additional, Hill, Susan, additional, Kershaw, Ann, additional, Mason, Sarah, additional, Paterson, Nicole, additional, Raymond, Lucy, additional, Swain, Rachel, additional, Guzman, Natalie Valle, additional, Busse, Monica, additional, Butcher, Cynthia, additional, Clenaghan, Catherine, additional, Hunt, Sarah, additional, Jones, Una, additional, Khalil, Hanan, additional, Owen, Michael, additional, Price, Kathleen, additional, Rosser, Anne, additional, Edwards, Maureen, additional, Ho, Carrie, additional, Hughes, Teresa, additional, McGill, Marie, additional, Pearson, Pauline, additional, Porteous, Mary, additional, Smith, Paul, additional, Brockie, Peter, additional, Foster, Jillian, additional, Johns, Nicola, additional, McKenzie, Sue, additional, Rothery, Jean, additional, Thomas, Gareth, additional, Yates, Shona, additional, Burrows, Liz, additional, Chu, Carol, additional, Fletcher, Amy, additional, Gallantrae, Deena, additional, Hamer, Stephanie, additional, Harding, Alison, additional, Klöppel, Stefan, additional, Kraus, Alison, additional, Laver, Fiona, additional, Lewis, Monica, additional, Longthorpe, Mandy, additional, Markova, Ivana, additional, Raman, Ashok, additional, Robertson, Nicola, additional, Silva, Mark, additional, Thomson, Aileen, additional, Wild, Sue, additional, Yardumian, Pam, additional, Evans, Carole, additional, Gallentrae, Deena, additional, Hobson, Emma, additional, Jamieson, Stuart, additional, Musgrave, Hannah, additional, Rowett, Liz, additional, Toscano, Jean, additional, Bourne, Colin, additional, Clapton, Jackie, additional, Clayton, Carole, additional, Dipple, Heather, additional, Freire-Patino, Dawn, additional, Grant, Janet, additional, Gross, Diana, additional, Hallam, Caroline, additional, Middleton, Julia, additional, Murch, Ann, additional, Thompson, Catherine, additional, Alusi, Sundus, additional, Davies, Rhys, additional, Foy, Kevin, additional, Gerrans, Emily, additional, Pate, Louise, additional, Andrews, Thomasin, additional, Dougherty, Andrew, additional, Golding, Charlotte, additional, Kavalier, Fred, additional, Laing, Hana, additional, Lashwood, Alison, additional, Robertson, Dene, additional, Ruddy, Deborah, additional, Santhouse, Alastair, additional, Whaite, Anna, additional, Bruno, Stefania, additional, Doherty, Karen, additional, Haider, Salman, additional, Hensman, Davina, additional, Lahiri, Nayana, additional, Novak, Marianne, additional, Patel, Aakta, additional, Rosser, Elisabeth, additional, Taylor, Rachel, additional, Warner, Thomas, additional, Wild, Edward, additional, Arran, Natalie, additional, Bek, Judith, additional, Craufurd, David, additional, Hare, Marianne, additional, Howard, Liz, additional, Huson, Susan, additional, Johnson, Liz, additional, Jones, Mary, additional, Murphy, Helen, additional, Oughton, Emma, additional, Partington-Jones, Lucy, additional, Rogers, Dawn, additional, Sollom, Andrea, additional, Snowden, Julie, additional, Stopford, Cheryl, additional, Thompson, Jennifer, additional, Trender-Gerhard, Iris, additional, Verstraelen, Nichola, additional, Westmoreland, Leann, additional, Armstrong, Richard, additional, Dixon, Kathryn, additional, Nemeth, Andrea H, additional, Siuda, Gill, additional, Valentine, Ruth, additional, Harrison, David, additional, Hughes, Max, additional, Parkinson, Andrew, additional, Soltysiak, Beverley, additional, Bandmann, Oliver, additional, Bradbury, Alyson, additional, Gill, Paul, additional, Fairtlough, Helen, additional, Fillingham, Kay, additional, Foustanos, Isabella, additional, Kazoka, Mbombe, additional, O'Donovan, Kirsty, additional, Taylor, Cat, additional, Tidswell, Katherine, additional, Quarrell, Oliver, additional, Lau, Puay Ngoh, additional, Pica, Emmanul, additional, and Tan, Louis, additional

Published
2017
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44. DNAJC6 Mutations Associated with Early-Onset Parkinson's Disease

Author

Olgiati, S. (Simone), Quadri, M. (Marialuisa), Fang, M. (Mingyan), Rood, J.P.M.A. (Janneke P.M.A.), Saute, J.A. (Jonas A.), Chien, H.F. (Hsin Fen), Bouwkamp, C.G. (Christian), Graafland, J. (Josja), Minneboo, M. (Michelle), Breedveld, G.J. (Guido J.), Zhang, J. (Jianguo), Verheijen, F.W. (Frans W.), Boon, A.J.W. (Agnita), Kievit, A.J.A. (Anneke J.A.), Jardim, L.B. (L.), Mandemakers, W.J. (Wim), Barbosa, E.R. (Egberto Reis), Rieder, C.R.M. (Carlos), Leenders, K.L. (Klaus L.), Wang, J. (Jinxia), Bonifati, V. (Vincenzo), Olgiati, S. (Simone), Quadri, M. (Marialuisa), Fang, M. (Mingyan), Rood, J.P.M.A. (Janneke P.M.A.), Saute, J.A. (Jonas A.), Chien, H.F. (Hsin Fen), Bouwkamp, C.G. (Christian), Graafland, J. (Josja), Minneboo, M. (Michelle), Breedveld, G.J. (Guido J.), Zhang, J. (Jianguo), Verheijen, F.W. (Frans W.), Boon, A.J.W. (Agnita), Kievit, A.J.A. (Anneke J.A.), Jardim, L.B. (L.), Mandemakers, W.J. (Wim), Barbosa, E.R. (Egberto Reis), Rieder, C.R.M. (Carlos), Leenders, K.L. (Klaus L.), Wang, J. (Jinxia), and Bonifati, V. (Vincenzo)

Abstract

_Objective_ DNAJC6 mutations were recently described in two families with autosomal recessive juvenile parkinsonism (onset age < 11), prominent atypical signs, poor or absent response to levodopa, and rapid progression (wheelchair-bound within ∼10 years from onset). Here, for the first time, we report DNAJC6 mutations in early-onset Parkinson's disease (PD). _Methods_ The DNAJC6 open reading frame was analyzed in 274 patients with early-onset sporadic or familial PD. Selected variants were followed up by cosegregation, homozygosity mapping, linkage analysis, whole-exome sequencing, and protein studies. _Results_ We identified two families with different novel homozygous DNAJC6 mutations segregating with PD. In each family, the DNAJC6 mutation was flanked by long runs of homozygosity within highest linkage peaks. Exome sequencing did not detect additional pathogenic variants within the linkage regions. In both families, patients showed severely decreased steady-state levels of the auxilin protein in fibroblasts. We also identified a sporadic patient carrying two rare noncoding DNAJC6 variants possibly effecting RNA splicing. All these cases fulfilled the criteria for a clinical diagnosis of early-onset PD, had symptoms onset in the third-to-fifth decade, and slow disease progression. Response to dopaminergic therapies was prominent, but, in some patients, limited by psychiatric side effects. The phenotype overlaps that of other monogenic forms of early-onset PD. _Interpretation_ Our findings delineate a novel form of hereditary early-onset PD. Screening of DNAJC6 is warranted in all patients with early-onset PD compatible with autosomal recessive inheritance. Our data provide further evidence for the involvement of synaptic vesicles endocytosis and trafficking in PD pathogenesis.

Published
2016
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47. Mapping human brain monoamine oxidase A and B with carbon eleven-labeled suicide inactivators and PET

Author

Fowler, J.S., MacGregor, R.R., Wolf, A.P., Arnett, C.D., Dewey, S.L., Schlyer, D., Christman, D., Logan, J., Smith, M., Sachs, H., Aquilonius, S.M., Bjurling, P., Halldin, C., Hartvig, P., Leenders, K.L., Lundquist, H., Oreland, L., Stalnacke, C.-G., and Langstrom, B.

Subjects
Brain research -- Usage -- Research, Neural transmission -- Research -- Usage, Parkinsonism -- Research, Monoamine oxidase -- Usage -- Research, Science and technology, Usage, Research
Abstract

Mapping Human Brain Monoamine Oxidase A and B with 11C-Labeled Suicide Inactivators and PET MONOAMINE OXIDASE (MAO)(E.C. 1.4.3.4) is responsible for the oxidative deamination of endogenous neurotransmitter amines as well [...]

Published
1987

48. [Br-76]bromodeoxyuridine PET in tumor-bearing animals

Author

Gardelle, O, Roelcke, U, Vontobel, P, Crompton, NEA, Guenther, [No Value], Blauenstein, P, Schubiger, AP, Blattmann, H, Ryser, JE, Leenders, K.L., and Kaser-Hotz, B

Subjects
F-18 FLUORODEOXYGLUCOSE, positron emission tomography, PROLIFERATIVE ACTIVITY, proliferation, FLOW-CYTOMETRY, INVIVO, [Br-76]bromodeoxyuridine, animal tumors, IN-VITRO, METABOLISM, BROMIDE, DOUBLING TIME, CELL-KINETICS, POSITRON-EMISSION-TOMOGRAPHY
Abstract

5-bromodeoxyuridine (BUdR) provides in vitro measures of tumor cell proliferation. We used positron emission tomography to study tissue and plasma kinetics of [Br-76]BUdR in tumor-bearing animals. In order to account for the slow washout of the major plasma metabolite, [Br-76]bromide, a mathematical correction for the distribution volume of [Br-76]bromide was applied. However, following correction specific tumor tracer retention was low or even zero and did not correlate with independent measures of proliferation. The kinetic characteristics of [Br-76]BUdR make this tracer unsuitable for proliferation imaging. (C) 2001 Elsevier Science Inc. All rights reserved.

Published
2001

49. Breakpoint mapping of 13 large parkin deletions/duplications reveals an exon 4 deletion and an exon 7 duplication as founder mutations

Author

Elfferich, P.C., Verleun-Mooijman, M.C. (Marja), Maat-Kievit, A.A. (Anneke), Warrenburg, B. (Bart) van de, Abdo, W.F. (Wilson), Eshuis, S.A. (Sylvia), Leenders, K.L. (Klaus), Hovestadt, A. (Ad), Zijlmans, J.C.M. (Jan), Stroy, J.-P.M., Swieten, J.C. (John) van, Boon, A.J.W. (Andrea), Engelen, K. (Klaartje) van, Verschuuren-Bemelmans, C.C. (Corien), Lesnik-Oberstein, S.A.J. (Saskia), Tassorelli, C. (Cristina), Lopiano, L. (Leonardo), Bonifati, V. (Vincenzo), Dooijes, D. (Dennis), Minkelen, R. (Rick) van, Elfferich, P.C., Verleun-Mooijman, M.C. (Marja), Maat-Kievit, A.A. (Anneke), Warrenburg, B. (Bart) van de, Abdo, W.F. (Wilson), Eshuis, S.A. (Sylvia), Leenders, K.L. (Klaus), Hovestadt, A. (Ad), Zijlmans, J.C.M. (Jan), Stroy, J.-P.M., Swieten, J.C. (John) van, Boon, A.J.W. (Andrea), Engelen, K. (Klaartje) van, Verschuuren-Bemelmans, C.C. (Corien), Lesnik-Oberstein, S.A.J. (Saskia), Tassorelli, C. (Cristina), Lopiano, L. (Leonardo), Bonifati, V. (Vincenzo), Dooijes, D. (Dennis), and Minkelen, R. (Rick) van

Abstract

Early-onset Parkinson's disease (EOPD) has been associated with recessive mutations in parkin (PARK2). About half of the mutations found in parkin are genomic rearrangements, i.e., large deletions or duplications. Although many different rearrangements have been found in parkin before, the exact breakpoints involving these rearrangements are rarely mapped. In the present study, the exact breakpoints of 13 different parkin deletions/duplications, detected in 13 patients out of a total screened sample of 116 EOPD patients using Multiple Ligation Probe Amplification (MLPA) analysis, were mapped using real time quantitative polymerase chain reaction (PCR), long-range PCR and sequence analysis. Deletion/duplication-specific PCR tests were developed as a rapid and low cost tool to confirmMLPA results and to test family members or patients with similar parkin deletions/duplications. Besides several different deletions, an exon 3 deletion, an exon 4 deletion and an exon 7 duplication were found in multiple families. Haplotype analysis in four families showed that a common haplotype of 1.2 Mb could be distinguished for the ex

Published
2011
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50. Breakpoint mapping of 13 large parkin deletions/duplications reveals an exon 4 deletion and an exon 7 duplication as founder mutations

Author

Elfferich, P., Verleun-Mooijman, M.C.T., Maat-Kievit, J.A., Warrenburg, B.P.C. van de, Abdo, W.F., Eshuis, S.A., Leenders, K.L., Hovestadt, A., Zijlmans, J.C.M., Stroy, J.P., Swieten, J.C. van, Boon, A.J., Engelen, K. van, Verschuuren-Bemelmans, C.C., Lesnik-Oberstein, S.A., Tassorelli, C., Lopiano, L., Bonifati, V., Dooijes, D., Minkelen, R. van, Elfferich, P., Verleun-Mooijman, M.C.T., Maat-Kievit, J.A., Warrenburg, B.P.C. van de, Abdo, W.F., Eshuis, S.A., Leenders, K.L., Hovestadt, A., Zijlmans, J.C.M., Stroy, J.P., Swieten, J.C. van, Boon, A.J., Engelen, K. van, Verschuuren-Bemelmans, C.C., Lesnik-Oberstein, S.A., Tassorelli, C., Lopiano, L., Bonifati, V., Dooijes, D., and Minkelen, R. van

Abstract

Item does not contain fulltext, Early-onset Parkinson's disease (EOPD) has been associated with recessive mutations in parkin (PARK2). About half of the mutations found in parkin are genomic rearrangements, i.e., large deletions or duplications. Although many different rearrangements have been found in parkin before, the exact breakpoints involving these rearrangements are rarely mapped. In the present study, the exact breakpoints of 13 different parkin deletions/duplications, detected in 13 patients out of a total screened sample of 116 EOPD patients using Multiple Ligation Probe Amplification (MLPA) analysis, were mapped using real time quantitative polymerase chain reaction (PCR), long-range PCR and sequence analysis. Deletion/duplication-specific PCR tests were developed as a rapid and low cost tool to confirm MLPA results and to test family members or patients with similar parkin deletions/duplications. Besides several different deletions, an exon 3 deletion, an exon 4 deletion and an exon 7 duplication were found in multiple families. Haplotype analysis in four families showed that a common haplotype of 1.2 Mb could be distinguished for the exon 7 duplication and a common haplotype of 6.3 Mb for the deletion of exon 4. These findings suggest common founder effects for distinct large rearrangements in parkin.

Published
2011

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