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2. Supplementary Figure 3 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., primary, Willson, Cynthia J., primary, Register, Thomas C., primary, Lees, Cynthia J., primary, Howard, Timothy D., primary, Huang, Zhiqing, primary, Murphy, Susan K., primary, Tooze, Janet A., primary, Chou, Jeff W., primary, Miller, Lance D., primary, and Cline, J. Mark, primary

Published
2023
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4. Data from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., primary, Willson, Cynthia J., primary, Register, Thomas C., primary, Lees, Cynthia J., primary, Howard, Timothy D., primary, Huang, Zhiqing, primary, Murphy, Susan K., primary, Tooze, Janet A., primary, Chou, Jeff W., primary, Miller, Lance D., primary, and Cline, J. Mark, primary

Published
2023
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5. Supplementary Figure 1 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., primary, Willson, Cynthia J., primary, Register, Thomas C., primary, Lees, Cynthia J., primary, Howard, Timothy D., primary, Huang, Zhiqing, primary, Murphy, Susan K., primary, Tooze, Janet A., primary, Chou, Jeff W., primary, Miller, Lance D., primary, and Cline, J. Mark, primary

Published
2023
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7. Supplementary Table 1 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., primary, Willson, Cynthia J., primary, Register, Thomas C., primary, Lees, Cynthia J., primary, Howard, Timothy D., primary, Huang, Zhiqing, primary, Murphy, Susan K., primary, Tooze, Janet A., primary, Chou, Jeff W., primary, Miller, Lance D., primary, and Cline, J. Mark, primary

Published
2023
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8. Supplementary Table 2 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., primary, Willson, Cynthia J., primary, Register, Thomas C., primary, Lees, Cynthia J., primary, Howard, Timothy D., primary, Huang, Zhiqing, primary, Murphy, Susan K., primary, Tooze, Janet A., primary, Chou, Jeff W., primary, Miller, Lance D., primary, and Cline, J. Mark, primary

Published
2023
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9. Supplementary Figure 2 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., primary, Willson, Cynthia J., primary, Register, Thomas C., primary, Lees, Cynthia J., primary, Howard, Timothy D., primary, Huang, Zhiqing, primary, Murphy, Susan K., primary, Tooze, Janet A., primary, Chou, Jeff W., primary, Miller, Lance D., primary, and Cline, J. Mark, primary

Published
2023
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11. Supplementary Table 3 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., primary, Willson, Cynthia J., primary, Register, Thomas C., primary, Lees, Cynthia J., primary, Howard, Timothy D., primary, Huang, Zhiqing, primary, Murphy, Susan K., primary, Tooze, Janet A., primary, Chou, Jeff W., primary, Miller, Lance D., primary, and Cline, J. Mark, primary

Published
2023
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15. Data from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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16. Supplementary Figure 2 from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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17. Supplementary Figure 1 from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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18. Supplementary Methods, Legends for Tables 1-2, Figures 1-4 from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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19. Supplementary Table 2 from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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20. Supplementary Figure 4 from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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21. Supplementary Figure 3 from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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22. Supplementary Table 1 from Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, primary, Cimic, Adela, primary, Romero, Lina, primary, Sui, Guangchao, primary, Lees, Cynthia J., primary, Cline, J. Mark, primary, Seals, Darren F., primary, Sirintrapun, Joseph S., primary, McCoy, Thomas P., primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Hawkins, Gregory A., primary, Peehl, Donna M., primary, Xu, Jianfeng, primary, and Cramer, Scott D., primary

Published
2023
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25. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

Author

Rayner, Katey J., Esau, Christine C., Hussain, Farah N., McDaniel, Allison L., Marshall, Stephanie M., van Gils, Janine M., Ray, Tathagat D., Sheedy, Frederick J., Goedeke, Leigh, Liu, Xueqing, Khatsenko, Oleg G., Kaimal, Vivek, Lees, Cynthia J., Fernandez-Hernando, Carlos, Fisher, Edward A., Temel, Ryan E., and Moore, Kathryn J.

Subjects
Physiological aspects, Research, Genetic aspects, Primates -- Genetic aspects -- Research, High density lipoproteins -- Physiological aspects -- Research, Very low density lipoproteins -- Physiological aspects -- Research, Low density lipoproteins -- Physiological aspects -- Research
Abstract

Recent advances in the understanding of lipid metabolism have revealed that the genetic loci encoding the transcription factors SREBP1 and SREBP2 (known as SREBF1 and SREBF2) also encode the miRNAs [...], Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-associated cholesterol. The pursuit of novel therapies to target the residual risk has focused on raising the levels of high-density lipoprotein (HDL)-associated cholesterol in order to exploit its atheroprotective effects (1). MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of lipid metabolism and are thus a new class of target for therapeutic intervention (2). MicroRNA-33a and microRNA-33b (miR-33a/b) are intronic miRNAs whose encoding regions are embedded in the sterol-response-element-binding protein genes SREBF2 and SREBF1 (refs 3-5), respectively. These miRNAs repress expression of the cholesterol transporter ABCA1, which is a key regulator of HDL biogenesis. Recent studies in mice suggest that antagonizing miR-33a may be an effective strategy for raising plasma HDL levels (3-5) and providing protection against atherosclerosis (6); however, extrapolating these findings to humans is complicated by the fact that mice lack miR-33b, which is present only in the SREBF1 gene of medium and large mammals. Here we show in African green monkeys that systemic delivery of an anti-miRNA oligonucleotide that targets both miR-33a and miR-33b increased hepatic expression of ABCA1 and induced a sustained increase in plasma HDL levels over 12 weeks. Notably, miR-33 antagonism in this non-human primate model also increased the expression of miR-33 target genes involved in fatty acid oxidation (CROT, CPT1A, HADHB and PRKAA1) and reduced the expression of genes involved in fatty acid synthesis (SREBF1, FASN, ACLY and ACACA), resulting in a marked suppression of the plasma levels of very-low-density lipoprotein (VLDL)-associated triglycerides, a finding that has not previously been observed in mice. These data establish, in a model that is highly relevant to humans, that pharmacological inhibition of miR-33a and miR33b is a promising therapeutic strategy to raise plasma HDL and lower VLDL triglyceride levels for the treatment of dyslipidaemias that increase cardiovascular disease risk.

Published
2011
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33. Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring

Author

Shively, Carol A., Clarkson, Thomas B., Wagner, Janice D., Jorgensen, Matthew J., Cline, J. Mark, Lees, Cynthia J., Franke, Adrian A., Li Zhang, Ayers, Melissa R., Schultz, Carrie, and Kaplan, Jay R.

Subjects
Soy protein -- Nutritional aspects, Soybean products -- Nutritional aspects, Casein -- Health aspects, Obesity -- Diet therapy, Monkeys -- Physiological aspects, Glycemic index -- Evaluation, Isoflavones -- Health aspects, Isoflavones -- Research, Anthropology/archeology/folklore, Biological sciences, Health, Psychology and mental health
Published
2009

34. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Author

Dewi, Fitriya N., primary, Wood, Charles E., additional, Willson, Cynthia J., additional, Register, Thomas C., additional, Lees, Cynthia J., additional, Howard, Timothy D., additional, Huang, Zhiqing, additional, Murphy, Susan K., additional, Tooze, Janet A., additional, Chou, Jeff W., additional, Miller, Lance D., additional, and Cline, J. Mark, additional

Published
2016
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36. The Evolving Mcart Multimodal Imaging Core

Author

de Faria, Eduardo B., primary, Barrow, Kory R., additional, Ruehle, Bradley T., additional, Parker, Jordan T., additional, Swartz, Elisa, additional, Taylor-Howell, Cheryl, additional, Kieta, Kaitlyn M., additional, Lees, Cynthia J., additional, Sleeper, Meg M., additional, Dobbin, Travis, additional, Baron, Adam D., additional, Mohindra, Pranshu, additional, and MacVittie, Thomas J., additional

Published
2015
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39. Suppression of Tak1 Promotes Prostate Tumorigenesis

Author

Wu, Min, primary, Shi, Lihong, additional, Cimic, Adela, additional, Romero, Lina, additional, Sui, Guangchao, additional, Lees, Cynthia J., additional, Cline, J. Mark, additional, Seals, Darren F., additional, Sirintrapun, Joseph S., additional, McCoy, Thomas P., additional, Liu, Wennuan, additional, Kim, Jin Woo, additional, Hawkins, Gregory A., additional, Peehl, Donna M., additional, Xu, Jianfeng, additional, and Cramer, Scott D., additional

Published
2012
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47. Behavioral response inhibition and maturation of goal representation in prefrontal cortex after puberty.

Author

Xin Zhou, Dantong Zhu, King, Samson G., Lees, Cynthia J., Bennett, Allyson J., Salinas, Emilio, Stanford, Terrence R., and Constantinidis, Christos

Subjects
PREFRONTAL cortex, STIMULUS synthesis, PUBERTY, PUBERTY -- Physiological aspects, MUTATIONAL falsetto, GENETICS, PHYSIOLOGY
Abstract

Executive functions including behavioral response inhibition mature after puberty, in tandem with structural changes in the prefrontal cortex. Little is known about how activity of prefrontal neurons relates to this profound cognitive development. To examine this, we tracked neuronal responses of the prefrontal cortex in monkeys as they transitioned from puberty into adulthood and compared activity at different developmental stages. Performance of the antisaccade task greatly improved in this period. Among neural mechanisms that could facilitate it, reduction of stimulus-driven activity, increased saccadic activity, or enhanced representation of the opposing goal location, only the latter was evident in adulthood. Greatly accentuated in adults, this neural correlate of vector inversion may be a prerequisite to the formation of a motor plan to look away from the stimulus. Our results suggest that the prefrontal mechanisms that underlie mature performance on the antisaccade task are more strongly associated with forming an alternative plan of action than with suppressing the neural impact of the prepotent stimulus. [ABSTRACT FROM AUTHOR]

Published
2016
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