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1. French protocol for the diagnosis and management of giant cell arteritis

Author

Aouba, Achille, Avouac, Jérôme, Cortet, Bernard, Darbon, Raphaël, De Wazieres, Benoît, Dieude, Philippe, Fautrel, Bruno, Gaxatte, Cédric, Gottenberg, Jacques-Eric, Granel, Brigitte, Greigert, Hélène, Jousse-Joulin, Sandrine, Liozon, Eric, Magnant, Julie, Mainbourg, Sabine, Martin, Thierry, Mirault, Tristan, Mouthon, Luc, Papo, Thomas, Pham, Thao, Puéchal, Xavier, Pugnet, Grégory, Ramon, André, Roca, Frédéric, Roubaud, Claire, Saadoun, David, Sevestre, Marie-Antoinette, Smets, Perrine, Terrier, Benjamin, Vignal, Catherine, de Boysson, Hubert, Devauchelle-Pensec, Valérie, Agard, Christian, André, Marc, Bienvenu, Boris, Bonnotte, Bernard, Carvajal Alegria, Guillermo, Espitia, Olivier, Hachulla, Eric, Heron, Emmanuel, Lambert, Marc, Lega, Jean-Christophe, Ly, Kim Heang, Mekinian, Arsène, Morel, Jacques, Regent, Alexis, Richez, Christophe, Sailler, Laurent, Seror, Raphaèle, Tournadre, Anne, and Samson, Maxime

Published
2025
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2. Use of immunosuppressants and biologics in giant cell arteritis: Recommendations of the French Study Group for Large Vessel Vasculitis (GEFA)

Author

de Boysson, Hubert, Devauchelle-Pensec, Valérie, Agard, Christian, André, Marc, Bienvenu, Boris, Bonnotte, Bernard, Carvajal Alegria, Guillermo, Espitia, Olivier, Hachulla, Eric, Héron, Emmanuel, Lambert, Marc, Lega, Jean-Christophe, Ly, Kim H., Mekinian, Arsène, Morel, Jacques, Régent, Alexis, Richez, Christophe, Sailler, Laurent, Seror, Raphaele, Tournadre, Anne, and Samson, Maxime

Published
2025
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3. The effects of plasma exchange and glucocorticoids on early kidney function among patients with ANCA-associated vasculitis in the PEXIVAS trial

Author

Paizis, Kathy, Walters, Giles, Jardine, Meg, Milton, Caroline, Ibraham, Abu, Siva, Brian, Desmond, Michael, Perkovic, Vlado, Kurtkoti, Jadadeesh, Vilayur, Eswari, Cass, Alan, Summers, Shaun, Brown, Fiona, Ryan, Jessica, Kerr, Peter, Noble, Euan, Luxton, Grant, Mudge, David W., Hawley, Carmel, Johnson, David W., Peh, Chen Au, Faull, Randall J., Ranganathan, Dwarakanathan, Jeffs, Lisa, Nicholls, Kathy, Hughes, Peter, Cooper, Bruce, Boudville, Neil, Ford, Sharon, Langham, Robyn, Reidlinger, Donna, AliciaMorrish, Badve, Sunil V., Pascoe, Elaine, Paul-Brent, Peta-Anne, Robison, Laura, Valks, Andrea, Blockmans, Daniel, Henckaerts, Liesbet, Sprangers, Ben, Suri, Rita, Brachemi, Soumeya, Clark, William, Garg, Amit, Carette, Simon, Pagnoux, Christian, Reich, Heather, Barth, David, Walsh, Michael, Khalidi, Nader, Cox, Gerry, Mazzetti, Andrea, Robins, Diane, Wald, Ron, Perl, Jeffrey, Pavenski, Katerina, Dacouris, Niki, Levin, Adeera, Copland, Michael, Fairhead, Todd, Pannu, Neesh, Qarni, Muhammad Uwais, Habib, Syed, Girard, Louis, Manns, Braden, Tesar, Vladimir, Hruskova, Zdenka, Chocova, Zdenka, Povlsen, Johan, Gregersen, Jon, Ivarsen, Per, Birn, Henrik, Krarup, Elizabeth, Pedersen, Erling B., Thomsen, Ingrid, Bech, Jesper Nørgaard, Szpirt, Wladmir, Egfjord, Martin, Mesbah, Rafik, Bataille, Pierre, Rey, Isabelle, Chantrel, François, Vanhille, Philipe, Quémeneur, Thomas, Carron, Pierre-Louis, Zaoui, Philippe, de Moreuil, Claire, Gosselin, Morgane, Delluc, Aurélien, Hanrotel-Saliou, Catherine, Le Jeune, Mathilde, Ficheux, Maxence, Aniort, Julien, Lavigne, Christian, Augusto, Jean Francois, Chauveau, Dominique, Guitard, Joëlle, Huart, Antoine, Ribes, David, Gatault, Philippe, Becmeur, Camille, Muller, Sandrine, Betz, Valérie, Klein, Alexandre, Blaison, Gilles, Seror, Raphaele, Francois, Hélène, Mariette, Xavier, Aubrun, Aurore, Coustet, Baptiste, Palazzo, Elisabeth, Ottaviani, Sébastien, Goulenok, Tiphaine, Daugas, Eric, Dieudé, Philipe, Papo, Thomas, Lebas, Céline, Lionet, Arnaud, Guillevin, Loïc, Mouthon, Luc, Puéchal, Xavier, Jourde-Chiche, Noémie, Ruivard, Marc, Karras, Alexandre, Limal, Nicolas, Kofman, Thomas, Le Quellec, Alain, Maurier, François, Gibelin, Aude, Parrot, Antoine, Bachmeyer, Claude, Gombert, Bruno, Nouvier, Mathilde, Lega, Jean-Christophe, Fain, Olivier, Andrès, Emmanuel, Cottet, Rachel, Gregorini, Gina, Jeannin, Guido, Possenti, Stefano, Buzio, Carlo, Vaglio, Augusto, Oliva, Elena, Makino, Hirofumi, Muso, Eri, Endo, Tomomi, Kakita, Hiroko, Suzuki, Hiroyuki, Handa, Takaya, Kang, Youngna, Ariyasu, Yuki, Tsukamoto, Tatsuo, Endo, Shuichiro, Miyata, Hitomi, Yamada, Hiroyuki, Ito-Ihara, Toshiko, Uchida, Shunya, Kono, Hajime, Fujigaki, Yoshihide, Kikuchi, Hirotoshi, Nanki, Toshihiro, Kato, Hideki, Okamoto, Akiko, Asako, Kurumi, Suzuki, Kazuo, Hamano, Yoshitomo, Yamagata, Kunihiro, Usui, Joichi, Fujimoto, Shouichi, Sato, Yuji, Kikuchi, Masao, Flores-Suárez, Luis Felipe, Sánchez-Guerrero, Sergio A., Collins, Michael, Schollum, John, de Zoysa, Janak, Quincy, Vicki, Sizeland, Peter, Aasarod, Knut, Solbu, Marit, Bruun, Trude Jannecke, Koldingsnes, Wenche, Wludarczyk, Anna, Nowak, Ilona, Gorka, Jacek, Sznajd, Jan, Padjas, Agnieszka, Jankowski, Milosz, Widawska, Agnieszka, Szczeklik, Wojciech, Ballarin, Jose, Bruchfeld, Annette, Efvergren, Mats, Eriksson, Per, Westman, Kerstin, Selga, Daina, Heijl, Caroline, Ohlsson, Sophie, Segelmark, Marten, Basu, Neil, Kidder, Dana, Fluck, Nicholas, Jayne, David R.W., Smith, Rona, Wilcocks, Lisa, McClure, Mark, Jones, Rachel, Trivedi, Sapna, Gopaluni, Seerapani, Brettell, Elizabeth, Crump, Paul, Feilbach, Annika, Hewitt, Catherine, Hilken, Nick, Howman, Andrew, Hughes, Terry, Ives, Natalie, Jarrett, Hugh, Mehta, Samir, Record, Rebecca, Ryan, Gemma, Sidile, Chaka, Wheatley, Keith, Sheerin, Brown, Alison, Baines, Laura Anne, Lordan, Jim, Pusey, Charles, Tanna, Anisha, McAdoo, Stephen, Levy, Jeremy, Griffith, Megan, Klebe, Bernhard, Doulton, Timothy, Warwick, Graham, Burton, James, Barratt, Jonathon, Topham, Peter, Baines, Richard, Brunskill, Nigel, Al-Jayyousi, Reem, Hamilton, Patrick, Patel, Mumtaz, Mitra, Sandip, Brown, Nina, Sharples, Edward, Luqmani, Raashid, Harper, Lorraine, Rhodes, Benjamin, Chanouzas, Dimitrios, Morgan, Matthew, Hewins, Peter, Floßmann, Oliver, Bhandary, Nitin, Foxton, Julie, Jones, Linda, King, Jenny, Smyth, Lucy, D’Souza, Richard, Haigh, Richard, Hough, Maxine, Salama, Alan, Burns, Aine, Little, Mark, Dhaun, Neeraj, Dhaygude, Ajay, Basnayake, Kolitha, Iggo, Neil, Jones, Daniel, Oliveira, David, MacPhee, Iain A.M., Dunn, Emma, Lewington, Andrew J.P., Fan, Stanley Linsun, Rajakariar, Ravindra, Yaqoob, Magdi, Short, Andrew, Geddes, Colin, Mackinnon, Bruce, Jardine, Alan G., Monach, Paul, Merkel, Peter A., Amudala, Naomi, Quillen, Karen, Weisman, Michael, Wallace, Daniel, Forbess, Lindsy, Venuturupalli, Swamy, Langford, Carol, Hajj-Ali, Rula, Koo, Anna, Hoffman, Gary, Specks, Ulrich, Keogh, Karina, Ytterberg, Steven, Winters, Jeff, Warrington, Kenneth, Cartin-Ceba, Rodrigo, Peikert, Tobias, Fervenza, Fernando, Baqir, Misbah, Nachman, Patrick, Detwiler, Randy, Mottl, Amy, Derebail, Vimal, McGregor, JulieAnne, Sreih, Antoine, Rhee, Rennie, McAlear, Carol, Aqui, Nicole, Moreland, Larry, Kiss, Joseph, Liang, Kimberly, Mohan, Niveditha, Balogun, Rasheed, Li, Tingting, Brasington, Richard, Odler, Balazs, Riedl, Regina, Geetha, Duvuru, Szpirt, Wladimir M., Uchida, Lisa, Wallace, Zachary S., Pusey, Charles D., Little, Mark A., and Kronbichler, Andreas

Published
2025
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4. Management and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study

Author

Douplat, Marion, Gavoille, Antoine, Subtil, Fabien, Haesebaert, Julie, Jacquin, Laurent, Durand, Guillaume, Lega, Jean-Christophe, Perpoint, Thomas, Potinet, Veronique, Berthiller, Julien, Perreton, Nathalie, and Tazarourte, Karim

Subjects
COVID-19, mortality, hospitalization, emergency department.
Abstract

Introduction: Few studies have investigated the management of COVID-19 cases from the operational perspective of the emergency department (ED), We sought to compare the management and outcome of COVID-19 positive and negative patients who presented to French EDs.Methods: We conducted a prospective, multicenter, observational study in four EDs. Included in the study were adult patients (≥18 years) between March 6–May 10, 2020, were hospitalized, and whose presenting symptoms were evocative of COVID-19. We compared the clinical features, management, and prognosis of patients according to their confirmed COVID-19 status. Results: Of the 2,686 patients included in this study, 760 (28.3%) were COVID-19 positive. Among them, 364 (48.0%) had hypertension, 228 (30.0%) had chronic cardiac disease, 186 (24.5%) had diabetes, 126 (16.6%) were obese, and 114 (15.0%) had chronic respiratory disease. The proportion of patients admitted to intensive care units (ICU) was higher among COVID-19 positive patients (185/760, 24.3%) compared to COVID-19 negative patients (206/1,926, 10.7%; P

Published
2022

8. Early-onset autoimmunity associated with SOCS1 haploinsufficiency.

Author

Hadjadj, Jérôme, Castro, Carla Noemi, Tusseau, Maud, Stolzenberg, Marie-Claude, Mazerolles, Fabienne, Aladjidi, Nathalie, Armstrong, Martin, Ashrafian, Houman, Cutcutache, Ioana, Ebetsberger-Dachs, Georg, Elliott, Katherine S, Durieu, Isabelle, Fabien, Nicole, Fusaro, Mathieu, Heeg, Maximilian, Schmitt, Yohan, Bras, Marc, Knight, Julian C, Lega, Jean-Christophe, Lesca, Gaetan, Mathieu, Anne-Laure, Moreews, Marion, Moreira, Baptiste, Nosbaum, Audrey, Page, Matthew, Picard, Cécile, Ronan Leahy, T, Rouvet, Isabelle, Ryan, Ethel, Sanlaville, Damien, Schwarz, Klaus, Skelton, Andrew, Viallard, Jean-Francois, Viel, Sebastien, Villard, Marine, Callebaut, Isabelle, Picard, Capucine, Walzer, Thierry, Ehl, Stephan, Fischer, Alain, Neven, Bénédicte, Belot, Alexandre, and Rieux-Laucat, Frédéric

Subjects
T-Lymphocytes, Humans, Autoimmune Diseases, Cytokines, Pedigree, Age of Onset, Signal Transduction, Autoimmunity, Mutation, Models, Molecular, Adolescent, Adult, Child, Child, Preschool, Female, Male, STAT Transcription Factors, Haploinsufficiency, Suppressor of Cytokine Signaling 1 Protein, Human Genome, Rare Diseases, Clinical Research, Genetics, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system
Abstract

Autoimmunity can occur when a checkpoint of self-tolerance fails. The study of familial autoimmune diseases can reveal pathophysiological mechanisms involved in more common autoimmune diseases. Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene in ten patients from five unrelated families with early onset autoimmune manifestations. The intracellular protein SOCS1 is known to downregulate cytokine signaling by inhibiting the JAK-STAT pathway. Accordingly, patient-derived lymphocytes exhibit increased STAT activation in vitro in response to interferon-γ, IL-2 and IL-4 that is reverted by the JAK1/JAK2 inhibitor ruxolitinib. This effect is associated with a series of in vitro and in vivo immune abnormalities consistent with lymphocyte hyperactivity. Hence, SOCS1 haploinsufficiency causes a dominantly inherited predisposition to early onset autoimmune diseases related to cytokine hypersensitivity of immune cells.

Published
2020

9. Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Author

Chouik, Yasmina, Lebossé, Fanny, Plissonnier, Marie-Laure, Lega, Jean-Christophe, Pradat, Pierre, Antonini, Teresa, Subic, Miroslava, Hartig-Lavie, Kerstin, Erard, Domitille, Villeret, François, Guichon, Céline, Payancé, Audrey, Radenne, Sylvie, Rautou, Pierre-Emmanuel, Zoulim, Fabien, and Levrero, Massimo

Published
2023
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10. Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Author

Guillet, Stéphanie, Crickx, Etienne, Azzaoui, Imane, Chappert, Pascal, Boutin, Emmanuelle, Viallard, Jean-François, Rivière, Etienne, Gobert, Delphine, Galicier, Lionel, Malphettes, Marion, Cheze, Stéphane, Lefrere, François, Audia, Sylvain, Bonnotte, Bernard, Lambotte, Olivier, Noel, Nicolas, Fain, Olivier, Moulis, Guillaume, Hamidou, Mohamed, Gerfaud-Valentin, Mathieu, Marolleau, Jean-Pierre, Terriou, Louis, Martis, Nihal, Morin, Anne-Sophie, Perlat, Antoinette, Le Gallou, Thomas, Roy-Peaud, Frédérique, Robbins, Ailsa, Lega, Jean-Christophe, Puyade, Matthieu, Comont, Thibault, Limal, Nicolas, Languille, Laetitia, Zarrour, Anissa, Luka, Marine, Menager, Mickael, Belmondo, Thibault, Hue, Sophie, Canoui-Poitrine, Florence, Michel, Marc, Godeau, Bertrand, and Mahévas, Matthieu

Published
2023
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12. Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Author

Guillet, Stéphanie, Loustau, Valentine, Boutin, Emmanuelle, Zarour, Anissa, Comont, Thibault, Souchaud-Debouverie, Odile, Costedoat Chalumeau, Nathalie, Pan-Petesch, Brigitte, Gobert, Delphine, Cheze, Stéphane, Viallard, Jean Francois, Morin, Anne-Sophie, Sauvetre, Gaetan, Cliquennois, Manuel, Royer, Bruno, Masseau, Agathe, Terriou, Louis, Fieschi, Claire, Lambotte, Olivier, Girault, Stéphane, Lioger, Bertrand, Audia, Sylvain, Sacre, Karim, Lega, Jean Christophe, Langlois, Vincent, Benachi, Alexandra, Orvain, Corentin, Devidas, Alain, Humbert, Sebastien, Gambier, Nicolas, Ruivard, Marc, Zarrouk, Virginie, Ebbo, Mikael, Willems, Lise, Segaux, Lauriane, Mahevas, Matthieu, Haddad, Bassam, Michel, Marc, Canoui-Poitrine, Florence, and Godeau, Bertrand

Published
2023
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13. Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Author

Moyon, Quentin, Pineton de Chambrun, Marc, Gousseff, Marie, Mathian, Alexis, Hie, Miguel, Urbanski, Geoffrey, Verlicchi, Franco, Faguer, Stanislas, Dossier, Antoine, Lega, Jean-Christophe, Riviere, Sophie, Saadoun, David, Graveleau, Julie, Lucchini-Lecomte, Marie-Josée, Christides, Christine, Le Moal, Sylvie, Bibes, Béatrice, Malizia, Giuseppe, Ruivard, Marc, Blaison, Gilles, Alric, Laurent, Agard, Christian, Soubrier, Martin, Viallard, Jean-François, Levesque, Hervé, Rivard, Georges-Etienne, Tieulie, Nathalie, Hot, Arnaud, Lovey, Pierre-Yves, Hanslik, Thomas, Lhote, François, Eble, Vincent, Álvarez Troncoso, Jorge, Aujayeb, Avinash, Quentric, Paul, Taieb, Dov, Cohen-Aubart, Fleur, Lambert, Marc, and Amoura, Zahir

Published
2022
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17. Heart and systemic sclerosis—findings from a national cohort study.

Author

Guédon, Alexis F, Carrat, Fabrice, Mouthon, Luc, Launay, David, Chaigne, Benjamin, Pugnet, Grégory, Lega, Jean-Christophe, Hot, Arnaud, Cottin, Vincent, Agard, Christian, Allanore, Yannick, Fauchais, Anne-Laure, Jego, Patrick, Dhote, Robin, Papo, Thomas, Chatelus, Emmanuel, Bonnotte, Bernard, Khan, Jean-Emmanuel, Diot, Elisabeth, and Bienvenu, Boris

Subjects
HEART disease complications, HEART disease risk factors, MORTALITY risk factors, HEART disease epidemiology, RISK assessment, HEART diseases, SEX distribution, CAUSES of death, DISEASE prevalence, DESCRIPTIVE statistics, CARDIOVASCULAR diseases risk factors, PERICARDITIS, LONGITUDINAL method, SYSTEMIC scleroderma, RESEARCH, SURVIVAL analysis (Biometry), DISEASE incidence, DISEASE complications, SYMPTOMS
Abstract

Objectives Heart involvement is one of the leading causes of death in SSc. The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases in a nationwide cohort of patients with SSc. Methods We used data from a multicentric prospective study using the French SSc national database. Focusing on SSc-related cardiac involvement, we aimed to determine its incidence and risk factors. Results Of the 3528 patients with SSc, 312 (10.9%) had SSc-related cardiac involvement at baseline. They tended to have a diffuse SSc subtype more frequently and to have more severe clinical features, and presented more cardiovascular risk factors. From the 1646 patients available for follow-up analysis, SSc-related cardiac involvement was associated with an increased risk of death. There was no significant difference in overall survival between SSc-related cardiac involvement, ischaemic heart disease or pulmonary arterial hypertension. Regarding survival analysis, 98 patients developed SSc-related cardiac involvement at 5 years (5-year event rate 11.15%). Regarding reduced left ventricular ejection fraction <50% and left ventricular diastolic dysfunction, the 5-year event rate was 2.49% and 5.84%, respectively. Pericarditis cumulative incidence at 5 years was 3%. Diffuse SSc subtype was a risk factor for SSc-related cardiac involvement and pericarditis. Female sex was associated with less left ventricular diastolic dysfunction incidence. Conclusions Our results describe the incidence and prognostic burden of SSc-related cardiac involvement at a large scale, with gender and diffuse SSc subtype as risk factors. Further analyses should assess the potential impact of treatment on these various cardiac outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Effective Anti–SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders

Author

Rossignol, Julien, Ouedrani, Amani, Livideanu, Cristina Bulai, Barete, Stéphane, Terriou, Louis, Launay, David, Lemal, Richard, Greco, Celine, Frenzel, Laurent, Meni, Cecile, Bodemere-Skandalis, Christine, Polivka, Laura, Collange, Anne-Florence, Hachichi, Hassiba, Bouzourine, Sonia, Messaoud, Djazira Nait, Negretto, Mathilde, Vendrame, Laurence, Jambou, Marguerite, Gousseff, Marie, Durupt, Stéphane, Lega, Jean-Christophe, Durand, Jean-Marc, Gaudy, Caroline, Damaj, Gandhi, Gourin, Marie-Pierre, Hamidou, Mohamed, Bouillet, Laurence, Le Mouel, Edwige, Maria, Alexandre, Zunic, Patricia, Cabrera, Quentin, Vincent, Denis, Lavigne, Christian, Riviere, Etienne, Gourguechon, Clement, Courbebaisse, Marie, Lebeaux, David, Parfait, Béatrice, Friedlander, Gérard, Brignier, Anne, Lhermitte, Ludovic, Molina, Thierry Jo, Bruneau, Julie, Agopian, Julie, Dubreuil, Patrice, Ranta, Dana, Mania, Alexandre, Arock, Michel, Staropoli, Isabelle, Tournilhac, Olivier, Lortholary, Olivier, Schwartz, Olivier, Chatenoud, Lucienne, and Hermine, Olivier

Published
2022
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22. Long-term follow-up of the STOPAGO study

Author

Cottu, Adrien, Guillet, Stéphanie, Viallard, Jean-François, Rivière, Etienne, Cheze, Stéphane, Gobert, Delphine, Neel, Antoine, Graveleau, Julie, Marolleau, Jean-Pierre, Lefrere, François, Moulis, Guillaume, Lega, Jean-Christophe, Moignet-Autrel, Aline, Robbins, Ailsa, Crickx, Etienne, Boutin, Emmanuelle, Noel, Nicolas, Malphettes, Marion, Galicier, Lionel, Audia, Sylvain, Bonnotte, Bernard, Lambotte, Olivier, Fain, Olivier, Gerfaud-Valentin, Mathieu, Terriou, Louis, Martis, Nihal, Morin, Anne-Sophie, Perlat, Antoinette, Le Gallou, Thomas, Roy-Peaud, Frédérique, Puyade, Matthieu, Comont, Thibault, Limal, Nicolas, Languille, Laetitia, Michel, Marc, Godeau, Bertrand, and Mahevas, Matthieu

Abstract

In an open prospective, multicenter study enrolling 48 selected patients with chronic immune thrombocytopenia who achieved complete response for 1 year on thrombopoietin receptor agonists, half of the patients maintained a sustained response off treatment 4 years after treatment discontinuation.

Published
2025
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24. Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Author

Gendreau, Ségolène, Porcher, Raphael, Thoreau, Benjamin, Paule, Romain, Maurier, François, Goulenok, Tiphaine, Frumholtz, Laure, Bernigaud, Charlotte, Ingen-Housz-Oro, Saskia, Mekinian, Arsène, Audemard-Verger, Alexandra, Gaillet, Antoine, Perard, Laurent, Samson, Maxime, Sonneville, Romain, Arlet, Jean-Benoît, Mirouse, Adrien, Kahn, Jean-Emmanuel, Charpentier, Julien, Hachulla, Éric, Hummel, Aurélie, Pires, Thomas, Carron, Pierre-Louis, Durel, Cécile-Audrey, Jourde, Wendy, Puechal, Xavier, Lega, Jean-Christophe, Sarrot-Reynauld, Françoise, Tieulie, Nathalie, Diot, Elisabeth, Guillevin, Loïc, and Terrier, Benjamin

Published
2021
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25. Vasodilator drugs and heart-related outcomes in systemic sclerosis: an exploratory analysis.

Author

Guédon, Alexis F., Carrat, Fabrice, Mouthon, Luc, Launay, David, Chaigne, Benjamin, Pugnet, Grégory, Lega, Jean-Christophe, Hot, Arnaud, Cottin, Vincent, Agard, Christian, Allanore, Yannick, Fauchais, Anne Laure, Lescoat, Alain, Dhote, Robin, Papo, Thomas, Chatelus, Emmanuel, Bonnotte, Bernard, Kahn, Jean-Emmanuel, Diot, Elisabeth, and Aouba, Achille

Published
2024
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26. ANCA-associated vasculitides: Recommendations of the French Vasculitis Study Group on the use of immunosuppressants and biotherapies for remission induction and maintenance

Author

Terrier, Benjamin, Charles, Pierre, Aumaître, Olivier, Belot, Alexandre, Bonnotte, Bernard, Crabol, Yoann, Durel, Cécile-Audrey, Ebbo, Mikael, Jourde-Chiche, Noémie, Lega, Jean-Christophe, Puéchal, Xavier, Pugnet, Grégory, Quemeneur, Thomas, Ribi, Camillo, Samson, Maxime, Vandergheynst, Frédéric, and Guillevin, Loïc

Published
2020
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28. Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

Author

Campion, Dominique, Dartigues, Jean-Francois, Deleuze, Jean-François, Genin, Emmanuelle, Lambert, Jean-Charles, Redon, Richard, Allain-Launay, Emma, Bader-Meunier, Brigitte, Belot, Alexandre, Bouayed, Kenza, Burtey, Stephane, Carbasse, Aurélia, Decramer, Stéphane, Despert, Véronique, Fain, Olivier, Fischbach, Michel, Flodrops, Hugues, Galeotti, Caroline, Hachulla, Eric, Hatchuel, Yves, Kleinmann, Jean-Francois, Kone-Paut, Isabelle, Lanteri, Aurélia, Lemelle, Irène, Maillard, Hélène, Maurier, François, Meinzer, Ulrich, Melki, Isabelle, Morell-Dubois, Sandrine, Pagnier, Anne, Piram, Maryam, Ranchin, Bruno, Reumaux, Héloise, Samaille, Charlotte, Sibilia, Jean, Weill, Olivia, Al-Abadi, Eslam, Armon, Kate, Bailey, Kathryn, Beresford, Michael, Brennan, Mary, Ciurtin, Coziana, Gardner-Medwin, Janet, Haslam, Kirsty, Hawley, Daniel, Leahy, Alice, Leone, Valentina, Mewar, Devesh, Moots, Rob, Pilkington, Clarissa, Ramanan, Athimalaipet, Rangaraj, Satyapal, Ratcliffe, Annie, Riley, Philip, Sen, Ethan, Sridhar, Arani, Wilkinson, Nick, Wood, Fiona, Rice, Gillian I, Omarjee, Sulliman Ommar, Rouchon, Quentin, Smith, Eve M D, Moreews, Marion, Tusseau, Maud, Frachette, Cécile, Bournhonesque, Raphael, Thielens, Nicole, Gaboriaud, Christine, Rouvet, Isabelle, Chopin, Emilie, Hoshino, Akihiro, Latour, Sylvain, Cimaz, Rolando, Romagnani, Paula, Malcus, Christophe, Fabien, Nicole, Sarda, Marie-Nathalie, Kassai, Behrouz, Lega, Jean-Christophe, Abou-Jaoude, Pauline, Bruce, Ian N, Simonet, Thomas, Bardel, Claire, Rollat-Farnier, Pierre Antoine, Viel, Sebastien, O'Sullivan, James, Walzer, Thierry, Mathieu, Anne-Laure, Marenne, Gaelle, Ludwig, Thomas, Ellingford, Jamie, Briggs, Tracy A, Beresford, Michael W, and Crow, Yanick J

Published
2020
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29. Sécurité des agents biologiques dans les maladies rhumatismales pédiatriques : étude rétrospective multicentrique en situation réelle dans la base de données JIRcohorte

Author

Cabrera, Natalia, Lega, Jean-Christophe, Kassai, Behrouz, Wouters, Carine, Kondi, Anuela, Cannizzaro, Elvira, Woerner, Andreas, Chausset, Aurelie, Roethlisberger, Samuel, Jeanneret, Cyril, Aeschlimann, Florence, Malik, Salma, Duquesne, Agnès, Kaiser, Daniela, Higel, Laetitia, Maes, Anne, Berthet, Gerald, Hentgen, Veronique, Kone-Paut, Isabelle, Belot, Alexandre, and Hofer, Michael

Published
2020
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31. Monogenic lupus: Dissecting heterogeneity

Author

Omarjee, Ommar, Picard, Cécile, Frachette, Cécile, Moreews, Marion, Rieux-Laucat, Frederic, Soulas-Sprauel, Pauline, Viel, Sebastien, Lega, Jean-Christophe, Bader-Meunier, Brigitte, Walzer, Thierry, Mathieu, Anne-Laure, Cimaz, Rolando, and Belot, Alexandre

Published
2019
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33. Safety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database

Author

Cabrera, Natalia, Lega, Jean-Christophe, Kassai, Behrouz, Wouters, Carine, Kondi, Anuela, Cannizzaro, Elvira, Woerner, Andreas, Chausset, Aurelie, Roethlisberger, Samuel, Jeanneret, Cyril, Aeschlimann, Florence, Malik, Salma, Duquesne, Agnès, Kaiser, Daniela, Higel, Laetitia, Maes, Anne, Berthet, Gerald, Hentgen, Veronique, Kone-Paut, Isabelle, Belot, Alexandre, and Hofer, Michael

Published
2019
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38. Mortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry

Author

Jardel, Sabine, Puéchal, Xavier, Le Quellec, Alain, Pagnoux, Christian, Hamidou, Mohamed, Maurier, François, Aumaitre, Olivier, Aouba, Achille, Quemeneur, Thomas, Subra, Jean-François, Cottin, Vincent, Sibilia, Jean, Godmer, Pascal, Cacoub, Patrice, Fauchais, Anne Laure, Hachulla, Eric, Maucort-Boulch, Delphine, Guillevin, Loïc, and Lega, Jean-Christophe

Published
2018
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42. Heart and systemic sclerosis—findings from a national cohort study

Author

Guédon, Alexis F, primary, Carrat, Fabrice, additional, Mouthon, Luc, additional, Launay, David, additional, Chaigne, Benjamin, additional, Pugnet, Grégory, additional, Lega, Jean-Christophe, additional, Hot, Arnaud, additional, Cottin, Vincent, additional, Agard, Christian, additional, Allanore, Yannick, additional, Fauchais, Anne-Laure, additional, Jego, Patrick, additional, Dhote, Robin, additional, Papo, Thomas, additional, Chatelus, Emmanuel, additional, Bonnotte, Bernard, additional, Khan, Jean-Emmanuel, additional, Diot, Elisabeth, additional, Bienvenu, Boris, additional, Magy-Bertrand, Nadine, additional, Queyrel, Viviane, additional, Le Quellec, Alain, additional, Kieffer, Pierre, additional, Amoura, Zahir, additional, Harlé, Jean-Robert, additional, Gaultier, Jean-Baptiste, additional, Balquet, Marie-Hélène, additional, Wahl, Denis, additional, Lidove, Olivier, additional, Fain, Olivier, additional, Mékinian, Arsène, additional, Hachulla, Eric, additional, and Rivière, Sebastien, additional

Published
2023
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43. Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents

Author

Ollier, Natasha, primary, Piel-Julian, Marie-Léa, additional, Mahévas, Matthieu, additional, Viallard, Jean-François, additional, Comont, Thibault, additional, Chèze, Stéphane, additional, Audia, Sylvain, additional, Ebbo, Mikaël, additional, Terriou, Louis, additional, Lega, Jean-Christophe, additional, Jeandel, Pierre-Yves, additional, Bonnotte, Bernard, additional, Michel, Marc, additional, Lapeyre-Mestre, Maryse, additional, Godeau, Bertrand, additional, and Moulis, Guillaume, additional

Published
2023
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44. Incidence of infections in patients with psoriatic arthritis and axial spondyloarthritis treated with biological or targeted disease-modifying agents: a systematic review and meta-analysis of randomised controlled trials, open-label studies and observational studies

Author

Aureal, Melanie, primary, Seauve, Milene, additional, Laplane, Soline, additional, Lega, Jean-Christophe, additional, Cabrera, Natalia, additional, and Coury, Fabienne, additional

Published
2023
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46. Difficult‐to‐treat primary immune thrombocytopenia in adults: Prevalence and burden. Results from the CARMEN‐France registry.

Author

Moulis, Guillaume, Rueter, Manuela, Duvivier, Aymeric, Mahévas, Matthieu, Viallard, Jean‐François, Comont, Thibault, Chèze, Stéphane, Audia, Sylvain, Ebbo, Mikaël, Terriou, Louis, Lega, Jean‐Christophe, Jeandel, Pierre‐Yves, Hemim, Ines, Bozzi, Sylvie, Daak, Ahmed, Okada, Hikaru, Bonnotte, Bernard, Michel, Marc, Lapeyre‐Mestre, Maryse, and Godeau, Bertrand

Subjects
IDIOPATHIC thrombocytopenic purpura, ADULTS, ROMIPLOSTIM, CONFIDENCE intervals, ELTROMBOPAG
Abstract

Summary: The aim of this study was to assess the prevalence and the burden of difficult‐to‐treat primary ITP (pITP), defined by the need for another ITP treatment after romiplostim and eltrombopag. Adult patients were selected in the prospective, real‐world CARMEN‐France registry up to December 2021. Out of 821 adult patients with pITP, 29 had difficult‐to‐treat ITP (3.5%; 95% confidence interval [CI]: 2.3%–4.8% in total; 7.6%; 95% CI: 4.9%–10.2% of patients needing ≥2nd line treatment). The 3‐year cumulative incidence of bleeding, infection and thrombosis was 100%, 24.1% and 13.8% respectively. The median cumulative duration of hospital stays was 31 days (median follow‐up: 30.3 months). [ABSTRACT FROM AUTHOR]

Published
2024
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47. Association between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis.

Author

Euvrard, Romain, Robert, Marie, Mainbourg, Sabine, Dalle, Stéphane, and Lega, Jean‐Christophe

Subjects
DRUG side effects, IMMUNE checkpoint inhibitors, MELANOMA, PROGNOSIS, PROGRESSION-free survival, BETA (Finance)
Abstract

Background: Immune checkpoint inhibitors (ICI) represent a breakthrough in oncology in terms of prognosis and safety. They now constitute a cornerstone in the management of metastatic melanoma. However, a new kind of adverse event called immune‐related adverse events (irAE) has emerged. These irAE could be conceptually considered as an indicator of the antitumoral immune response, but the association between irAE and prognosis is still a matter of debate. Objective: The purpose of this study was to investigate the association between the overall survival (OS) and the prevalence of irAE in melanoma. Methods: MEDLINE/PubMed, WebofScience, ClinicalTrials, and WHOTrials databases were searched to identify phase 3 randomized controlled trials (RCT) assessing ICI in melanoma and published up to April 2021. A weighted regression was performed to estimate this association according to standard method of surrogacy analysis. Results: A total of 14 RCT including 7646 patients (median age: 59.3 years) with melanoma were included. All types of ICI were represented (ipilimumab, tremelimumab, pembrolizumab, nivolumab, atezolizumab, as well as ipilimumab and nivolumab combination). irAE were frequent but rarely fatal. The combination of ICI caused more irAE than anti‐PD1 (or PDL1) and anti‐CTLA4 monotherapies. No relationship was found between the occurrence of irAE and OS (beta coefficient 0.078, R2 3%, p = 0.52), nor between cutaneous irAE and OS (beta coefficient 0.080, R2 6%, p = 0.33). Conclusion: Although limited by the heterogeneity of ICI included in the regression and the low number of included RCT, the present study suggests an absence of association between irAE and prognosis in melanoma. [ABSTRACT FROM AUTHOR]

Published
2024
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