48 results on '"Legay, Rémi"'
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2. Synthesis and biological evaluation of benzodiazepines containing a pentafluorosulfanyl group
3. Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax
4. Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode
5. Sequential one pot double C[sbnd]H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes
6. Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
7. Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease
8. Facile access to γ-aminothiols from 1,3-thiazines via a microwave-assisted three-component reaction
9. Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
10. Synthesis of new linear poly(phenylpyridyl) chains
11. First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
12. Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to ( Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity
13. General method for the synthesis of substituted phenanthridin-6(5 H)-ones using a KOH-mediated anionic ring closure as the key step
14. Convergent access to mono-fluoroalkene-based peptidomimetics
15. Michael addition to a chiral non-racemic 2-phosphono-2,3-didehydrothiolane S-oxide
16. A rapid and versatile synthesis of novel pyrimido[5,4- b]carbazoles
17. A general synthesis of halo-oligopyridines. The Garlanding concept
18. Media‐Driven Pd‐Catalyzed Reaction Cascades with 1,3‐Diynamides Leading Selectively to Either Indoles or Quinolines
19. Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use
20. Design and synthesis of a new indazole library: direct conversion of N-methoxy- N-methylamides (Weinreb amides) to 3-keto and 3-formylindazoles
21. The synthesis of three new heterocycles: the pyrido[4,3 or 3,4 or 2,3- c]-1,5-naphthyridines
22. Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy
23. N-substituted Piperazinopyridylsteroid Derivatives as Abiraterone Analogues Inhibit Growth and Induce Pro-apoptosis in Human Hormone-independent Prostate Cancer Cell Lines
24. First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease
25. Cardiotoxicity and Neurotoxicity of High-Dose Continuous Fluorouracil As a Result of Degradation Compounds in the Drug Vials
26. Difluorophosphonylated Allylic Ether Moiety as a 2′-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies
27. Abstract 3996: Pyridoclax and its derivatives from oligopyridine family directly inhibit Mcl-1 and exert potent antitumor effects on ovarian cancer in vitro and in vivo
28. First Examples of Povarov Reaction of Cyclopentadienones
29. β-Strand Mimicry: Exploring Oligothienylpyridine Foldamers
30. Sequential one pot double C H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes
31. Back Cover: Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment (ChemMedChem 12/2017)
32. Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
33. Four Partners, Three-Step, One-Pot Reaction for a Library of New 2-Alkyl(dialkyl)aminoquinazolin-4(3 H )-ones
34. Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines
35. An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one
36. Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease
37. Stereoselective Ring-Opening Reaction of α-Fluorinated Oxetanes: A Practical and Theoretical Investigation
38. Four Partners, Three-Step, One-Pot Reaction for a Library of New 2-Alkyl(dialkyl)aminoquinazolin-4(3H)-ones
39. Zinc and cobalt complexes based on tripodal ligands: synthesis, structure and reactivity toward lactide
40. Pummerer-type reactions in the (2-methylsulfanyl-2-phosphonyl) thiopyran 1-oxide series
41. Structural Characterizations of Oligopyridyl Foldamers, α-Helix Mimetics
42. General method for the synthesis of substituted phenanthridin-6(5H)-ones using a KOH-mediated anionic ring closure as the key step
43. Environmentally benign metal-free decarboxylative aldol and Mannich reactions
44. Synthesis of 2,3-trans Disubstituted Tetrahydrofurans through Sequential Xanthate Radical Addition−Substitution Reactions
45. Synthesis of 2,3-trans Disubstituted Tetrahydrofurans through Sequential Xanthate Radical Addition-Substitution Reactions.
46. First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease.
47. Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines.
48. Structural characterizations of oligopyridyl foldamers, α-helix mimetics.
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