183 results on '"Legewie, Stefan"'
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2. Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-$\beta$ signaling
3. Network switches and their role in circadian clocks
4. Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
5. Modelling cellular signalling variability based on single-cell data: the TGFb/SMAD signaling pathway
6. FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns
7. Modeling Cellular Signaling Variability Based on Single-Cell Data: The TGFβ-SMAD Signaling Pathway
8. Transcriptional regulators ensuring specific gene expression and decision making at high TGFβ doses
9. High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance
10. Mechanisms generating network switches and their role in circadian clocks
11. Network switches and their role in circadian clocks.
12. Small RNAs Establish Delays and Temporal Thresholds in Gene Expression
13. Data from Atypical Protein Kinase C ζ Exhibits a Proapoptotic Function in Ovarian Cancer
14. Supplementary Data from Atypical Protein Kinase C ζ Exhibits a Proapoptotic Function in Ovarian Cancer
15. State- and stimulus-specific dynamics of SMAD signaling determine fate decisions in individual cells
16. Quantifying post-transcriptional regulation in the development of Drosophila melanogaster
17. Modeling Formalisms in Systems Biology of Apoptosis
18. Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction
19. Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
20. Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling
21. Machine Learning-Assisted Identification of Factors Contributing to the Technical Variability Between Bulk and Single-Cell RNA-Seq Experiments
22. Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development
23. High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance
24. Robustness of signal transduction pathways
25. Applications in Cancer Research: Mathematical Models of Apoptosis
26. Modeling Formalisms in Systems Biology of Apoptosis
27. Exon Definition Facilitates Reliable Control of Alternative Splicing in the RON Proto-Oncogene
28. A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts
29. Effects of sequestration on signal transduction cascades
30. Quantitative analysis of ultrasensitive responses
31. In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors
32. Estrogen‐dependent control and cell‐to‐cell variability of transcriptional bursting
33. Sharing of Phosphatases Promotes Response Plasticity in Phosphorylation Cascades
34. Cell‐specific responses to the cytokine TGF β are determined by variability in protein levels
35. Abschlussbericht e:bio Consortium OncoPath - 'Dissecting and modeling vulnerabilities of oncogenic pathways and metabolism in solid cancers' : Vorhabensbezeichnung: e:Bio - Modul II - Verbundprojekt: OncoPath - Modellierung und Analyse von Signalwegen und Metabolismus in soliden Tumoren - Teilprojekt E : Laufzeit des Vorhabens: 01.01.2013-31.01.2016
36. Correlated receptor transport processes buffer single-cell heterogeneity
37. Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms
38. Exon Definition Facilitates Reliable Control of Alternative Splicing in the RONProto-Oncogene
39. Identifying Novel Transcriptional Regulators with Circadian Expression
40. Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways
41. Correction: Multi-Target Regulation by Small RNAs Synchronizes Gene Expression Thresholds and May Enhance Ultrasensitive Behavior
42. Cell‐specific responses to the cytokine TGFβ are determined by variability in protein levels.
43. Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR
44. Silence on the relevant literature and errors in implementation
45. Systems biological analyses of intracellular signal transduction
46. Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction
47. Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis
48. A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis
49. Determinants of Cell-to-Cell Variability in Protein Kinase Signaling
50. Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
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