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2. Instance Segmentation of Dislocations in TEM Images

Author

Ruzaeva, Karina, Govind, Kishan, Legros, Marc, and Sandfeld, Stefan

Subjects
Computer Science - Computer Vision and Pattern Recognition, Condensed Matter - Materials Science
Abstract

Quantitative Transmission Electron Microscopy (TEM) during in-situ straining experiment is able to reveal the motion of dislocations -- linear defects in the crystal lattice of metals. In the domain of materials science, the knowledge about the location and movement of dislocations is important for creating novel materials with superior properties. A long-standing problem, however, is to identify the position and extract the shape of dislocations, which would ultimately help to create a digital twin of such materials. In this work, we quantitatively compare state-of-the-art instance segmentation methods, including Mask R-CNN and YOLOv8. The dislocation masks as the results of the instance segmentation are converted to mathematical lines, enabling quantitative analysis of dislocation length and geometry -- important information for the domain scientist, which we then propose to include as a novel length-aware quality metric for estimating the network performance. Our segmentation pipeline shows a high accuracy suitable for all domain-specific, further post-processing. Additionally, our physics-based metric turns out to perform much more consistently than typically used pixel-wise metrics.

Published
2023
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3. Variability of cortico‐cortical evoked potentials in the epileptogenic zone is related to seizure occurrence

Author

Odile Feys, Vincent Wens, Sophie Schuind, Estelle Rikir, Benjamin Legros, Xavier De Tiège, and Nicolas Gaspard

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Introduction Cortico‐cortical evoked potentials (CCEPs) were described as reproducible during trains of single‐pulse electrical stimulations (SPES). Still, few studies described a variability of CCEPs that was higher within the epileptogenic zone (EZ). This study aimed at characterizing the relationship of CCEP variability with the occurrence of interictal/ictal epileptiform discharges at the temporal vicinity of the stimulation, but not during the stimulation, by effective connectivity modifications. Methods We retrospectively included 20 patients who underwent SPES during their stereo‐electroencephalography (SEEG). We analyzed the variability of CCEPs by using the post‐stimulation time course of intertrial standard deviation (amplitude) and the timing of peak amplitude signal of CCEP epochs (latency). Values were corrected for the Euclidian distance between stimulating/recording electrodes. Receiver operating characteristics curves were used to assess the relationship with the EZ. The link between CCEP variability and interictal discharges occurrence, seizure frequency prior to the SEEG recording, and number of seizures during SEEG recording was assessed with Spearman's correlations. Results A relationship was demonstrated between the EZ and both the distance‐corrected latency variation (area under the curve (AUC): 0.73–0.74) and the distance‐corrected amplitude variation (AUC: 0.71–0.72) and both were related with the occurrence of seizures. Conclusion Seizures before/during SEEG impact the dynamics of effective connectivity within the epileptogenic network by reducing the variability of CCEP latency/amplitude when the seizure frequency increases. It suggests a strengthening of the epileptogenic network with the occurrence of many seizures. These findings stress the importance of early epilepsy surgery at a time when the network organization has not yet been complete.

Published
2024
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4. The Impact of Online Behavioral Advertising on Consumer Attitude and Impulse Buying: The Moderating Role of Privacy Concerns

Author

Elisa Legros, Yoonju Han, and Jeong Eun Park

Subjects
online behavioral advertising, impulse buying, consumer privacy, cultural difference, Business, HF5001-6182
Abstract

Online Behavioral Advertising (OBA), a recently emerging format of internet advertising, targets users based on their past online behaviors. This study examines the impact of OBA on consumer attitudes and impulse buying behavior, while exploring the moderating influence of privacy concerns, a crucial factor given that OBA relies on personal data collection. To test our conceptual model, we conducted surveys in Korea and France, to further analyze the potential cultural distinctions. Our findings, derived from a series of linear regression models, reveal that OBA significantly affects consumers' impulse buying, with this effect mediated by consumers' attitudes toward OBA. Moreover, consumers' privacy concerns weaken the positive effect of OBA on attitudes. Notably, we observe significant cultural differences, with these effects primarily manifesting in the Korean sample. Our study provides valuable insights for creating effective online advertising strategies that contribute to consumers' purchase funnel, ultimately leading to purchases, while addressing privacy concerns and cultural variations.

Published
2024
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5. Fine mapping of RNA isoform diversity using an innovative targeted long-read RNA sequencing protocol with novel dedicated bioinformatics pipeline

Author

Camille Aucouturier, Nicolas Soirat, Laurent Castéra, Denis Bertrand, Alexandre Atkinson, Thibaut Lavolé, Nicolas Goardon, Céline Quesnelle, Julien Levilly, Sosthène Barbachou, Angelina Legros, Olivier Caron, Louise Crivelli, Philippe Denizeau, Pascaline Berthet, Agathe Ricou, Flavie Boulouard, Dominique Vaur, Sophie Krieger, and Raphael Leman

Subjects
RNA splicing, Long read sequencing, HBOC, Isoform assembly, Automatic annotation, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Solving the structure of mRNA transcripts is a major challenge for both research and molecular diagnostic purposes. Current approaches based on short-read RNA sequencing and RT-PCR techniques cannot fully explore the complexity of transcript structure. The emergence of third-generation long-read sequencing addresses this problem by solving this sequence directly. However, genes with low expression levels are difficult to study with the whole transcriptome sequencing approach. To fix this technical limitation, we propose a novel method to capture transcripts of a gene panel using a targeted enrichment approach suitable for Pacific Biosciences and Oxford Nanopore Technologies platforms. Results We designed a set of probes to capture transcripts of a panel of genes involved in hereditary breast and ovarian cancer syndrome. We present SOSTAR (iSofOrmS annoTAtoR), a versatile pipeline to assemble, quantify and annotate isoforms from long read sequencing using a new tool specially designed for this application. The significant enrichment of transcripts by our capture protocol, together with the SOSTAR annotation, allowed the identification of 1,231 unique transcripts within the gene panel from the eight patients sequenced. The structure of these transcripts was annotated with a resolution of one base relative to a reference transcript. All major alternative splicing events of the BRCA1 and BRCA2 genes described in the literature were found. Complex splicing events such as pseudoexons were correctly annotated. SOSTAR enabled the identification of abnormal transcripts in the positive controls. In addition, a case of unexplained inheritance in a family with a history of breast and ovarian cancer was solved by identifying an SVA retrotransposon in intron 13 of the BRCA1 gene. Conclusions We have validated a new protocol for the enrichment of transcripts of interest using probes adapted to the ONT and PacBio platforms. This protocol allows a complete description of the alternative structures of transcripts, the estimation of their expression and the identification of aberrant transcripts in a single experiment. This proof-of-concept opens new possibilities for RNA structure exploration in both research and molecular diagnostics.

Published
2024
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6. Frailty and 6-month trajectory of elderly trauma patients over the age of 65 years admitted to intensive care unit for severe trauma: experience of a level 1 trauma center

Author

Vincent Legros, Pierre-Antoine Seube-Remy, Thierry Floch, Cindy Chauchard, Marion Leclercq-Rouget, Pierre-Alexandre Prevot-Minella, Alice Duvivier, Lucas Flamant, and Lukshe Kanagaratnam

Subjects
Trauma, Mortality, Trajectory frailty, Elderly patients, Clinical frailty scale, Geriatrics, RC952-954.6
Abstract

Abstract Background The aging global population forecasts a significant rise in severe trauma cases among individuals aged 65 and above. Frailty emerges as a paramount predictor of post-traumatic outcomes, surpassing age and trauma severity indices. Despite this, scant attention is given to the trajectory of elderly patients post-intensive care unit (ICU) stay following severe trauma, justifying this study. The objective of this study was to analyze trajectories (frailty, place of residence) following a major trauma requiring an ICU stay. Materials and methods An observational cohort study was conducted, leveraging data from a level 1 trauma center spanning 2018 to 2023. Inclusion criteria included elderly patients aged 65 and above admitted to the ICU for severe trauma. Data encompassed demographic profiles, trauma severity scores, clinical parameters, and frailty assessments sourced from the Traumabase database. Results Among 293 patients included 190 were non-frail, frailty was correlated with elevated mortality rates (114 (38.9%) at 6 months), heightened incidence of traumatic brain injuries, and notable declines in post-traumatic autonomy. Only 39.2% of patients had resumed residence at home six months post-injury, with a conspicuous trend towards institutionalization, particularly among frail individuals. Conclusion This study highlights the role of frailty in determining the outcomes of elderly patients following severe trauma. Frailty is associated with higher mortality, increased rates of institutionalization, and a decline in functional status. These results highlight the importance of assessing frailty in the trajectory of severely injured patients over the age of 65 years-old.

Published
2024
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8. Deep Learning of Crystalline Defects from TEM images: A Solution for the Problem of 'Never Enough Training Data'

Author

Govind, Kishan, Oliveros, Daniela, Dlouhy, Antonin, Legros, Marc, and Sandfeld, Stefan

Subjects
Computer Science - Computer Vision and Pattern Recognition, Condensed Matter - Materials Science
Abstract

Crystalline defects, such as line-like dislocations, play an important role for the performance and reliability of many metallic devices. Their interaction and evolution still poses a multitude of open questions to materials science and materials physics. In-situ TEM experiments can provide important insights into how dislocations behave and move. During such experiments, the dislocation microstructure is captured in form of videos. The analysis of individual video frames can provide useful insights but is limited by the capabilities of automated identification, digitization, and quantitative extraction of the dislocations as curved objects. The vast amount of data also makes manual annotation very time consuming, thereby limiting the use of Deep Learning-based, automated image analysis and segmentation of the dislocation microstructure. In this work, a parametric model for generating synthetic training data for segmentation of dislocations is developed. Even though domain scientists might dismiss synthetic training images sometimes as too artificial, our findings show that they can result in superior performance, particularly regarding the generalizing of the Deep Learning models with respect to different microstructures and imaging conditions. Additionally, we propose an enhanced deep learning method optimized for segmenting overlapping or intersecting dislocation lines. Upon testing this framework on four distinct real datasets, we find that our synthetic training data are able to yield high-quality results also on real images-even more so if fine-tune on a few real images was done.

Published
2023

10. Fine mapping of RNA isoform diversity using an innovative targeted long-read RNA sequencing protocol with novel dedicated bioinformatics pipeline

Author

Aucouturier, Camille, Soirat, Nicolas, Castéra, Laurent, Bertrand, Denis, Atkinson, Alexandre, Lavolé, Thibaut, Goardon, Nicolas, Quesnelle, Céline, Levilly, Julien, Barbachou, Sosthène, Legros, Angelina, Caron, Olivier, Crivelli, Louise, Denizeau, Philippe, Berthet, Pascaline, Ricou, Agathe, Boulouard, Flavie, Vaur, Dominique, Krieger, Sophie, and Leman, Raphael

Published
2024
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12. The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells

Author

Ritter, Maureen, Canus, Lola, Gautam, Anupriya, Vallet, Thomas, Zhong, Li, Lalande, Alexandre, Boson, Bertrand, Gandhi, Apoorv, Bodoirat, Sergueï, Burlaud-Gaillard, Julien, Freitas, Natalia, Roingeard, Philippe, Barr, John N., Lotteau, Vincent, Legros, Vincent, Mathieu, Cyrille, Cosset, François-Loïc, and Denolly, Solène

Published
2024
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13. Diagnostic management of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in close interaction with therapeutic considerations

Author

Shumilov, Evgenii, Mazzeo, Paolo, Ghandili, Susanne, Künstner, Axel, Weidemann, Sören, Banz, Yara, Ströbel, Philipp, Pollak, Matthias, Kolloch, Lina, Beltraminelli, Helmut, Kerkhoff, Andrea, Mikesch, Jan-Henrik, Schliemann, Christoph, Haase, Detlef, Wulf, Gerald, Legros, Myriam, Lenz, Georg, Feldmeyer, Laurence, Pabst, Thomas, Witte, Hanno, Gebauer, Niklas, and Bacher, Ulrike

Published
2024
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17. Comparison and Impact of Waste Heat Recovery Technologies on Passenger Car Fuel Consumption in a Normalized Driving Cycle

Author

Legros Arnaud, Guillaume Ludovic, Diny Mouad, Zaïdi Hamid, and Lemort Vincent

Subjects
passenger car, rankine cycle, turbocompound, thermoelectricity, driving cycle, Technology
Abstract

The purpose of this article was to compare different waste heat recovery system technologies designed for automotive applications. A complete literature review is done and results in two comparative graphs. In the second part, simulation models are built and calibrated in order to assess the fuel consumption reduction that can be achieved on a real driving cycle. The strength of this article is that the models are calibrated using actual data. Finally, those simulations results are analyzed and the Rankine cycle and turbocompound are the two most profitable solutions. However the simulations of the turbocompound shows its limitations because the impact on the exhaust pressure drop is not taken into account in the assessment of the car fuel consumption. Fuel reduction of up to 6% could be achieved, depending on the driving cycle and the waste heat recovery technology.

Published
2014
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18. Assessment of inter-regional dietary differences in anadromous Arctic char (Salvelinus alpinus) in Nunavik, Canada, and links with flesh quality indicators

Author

Sara Bolduc, Mélanie Lemire, Jean-Éric Tremblay, Marianne Falardeau, Xavier Dallaire, Mylène Brochu, Justine Legros, and Jean-Sébastien Moore

Subjects
Stable isotopes1, omega-3 fatty acids2, astaxanthin3, bio-impedance4, colorimetry5, Environmental sciences, GE1-350, Environmental engineering, TA170-171
Abstract

Arctic char (Salvelinus alpinus) is a salmonid fish that is the second-most consumed country food species by Nunavimmiut. Its nutritional quality is determined by omega-3 fatty acids and carotenoid pigments. Those molecules cannot be synthetized by fish and must be acquired through diet. We sampled Arctic char in 10 rivers from the three marine coastal regions of Nunavik (Hudson Bay, Hudson Strait, and Ungava Bay), described diet (stable isotopes δ13C and δ15N) and flesh quality (fatty acids and carotenoids, measured by chromatography) and assessed associations between both diet and flesh quality (including also bio-impedance and colorimetry). Our results suggested inter-regional differences in the diet and nutritional quality of Arctic char in Nunavik, where δ13C values indicated that the diet of Arctic char in Hudson Bay was more pelagic, while in Ungava Bay it was more coastal. We also observed inter-regional differences in omega-3 fatty acids and astaxanthin, the pigment responsible for the redness of the flesh color, where concentrations were highest in Ungava Bay Arctic char. In all sampling locations, Arctic char were an exceptional source of omega-3 fatty acids and astaxanthin, confirming its importance as a high-quality wild food. Our models suggest that astaxanthin, canthaxanthin, and water content influence flesh redness. Our data highlight inter-regional differences that could be taken in consideration to better predict the impact of climate change on fish quality and, ultimately, on Inuit diet and health.

Published
2024
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20. Time-Frequency Ridge Estimation of Multi-Component Signals using Sparse Modeling of Signal Innovation

Author

Legros, Quentin and Fourer, Dominique

Subjects
Mathematics - Numerical Analysis
Abstract

This paper presents a novel approach for estimating the modes of an observed non-stationary mixture signal. A link is first established between the short-time Fourier transform and the sparse sampling theory, where the observations are modeled as a stream of pulses filtered by a known function. As the signal to retrieve has a finite rate of innovation (FRI), an adapted reconstruction approach is used to estimate the signal modes in the presence of noise. We compare our results with state-of-the-art methods and validate our approach by highlighting an improvement of the estimation performance in different scenarios. Our approach paves the way of future FRI-based mode disentangling algorithms.

Published
2022

22. Towards Wearable Continuous Point-of-Care Monitoring for Deep Vein Thrombosis of the Lower Limb

Author

the ThrombUS+ Consortium, Kaldoudi, Eleni, Marozas, Vaidotas, Rytis, Jurkonis, Pousset, Nicolas, Legros, Mathieu, Kircher, Marco, Novikov, Dmitry, Sakalauskas, Andrius, Moustakidis, Pavlos, Ayinde, Babajide, Moltani, Lara Alessia, Balling, Susann, Vehkaoja, Antti, Oksala, Niku, Macas, Andrius, Balciuniene, Neringa, Bigaki, Maria, Potoupnis, Michail, Papadopoulou, Stella-Lida, Grandone, Elvira, Gautier, Maxime, Bouda, Sabrina, Schloetelburg, Cord, Prinz, Thorsten, Dionisio, Pietro, Anagnostopoulos, Spyridon, Drougka, Ioanna, Folkvord, Frans, Drosatos, George, Didaskalou, Stylianos, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Jarm, Tomaž, editor, Šmerc, Rok, editor, and Mahnič-Kalamiza, Samo, editor

Published
2024
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23. Transient staffing at the beginning of work.

Author

Legros, Benjamin and Jouini, Oualid

Subjects
SUPPLY & demand, EMPLOYEE selection
Abstract

Production and service systems often rely on stationary queueing formulas to determine the number of agents that need to be scheduled. However, this results in over-staffing decisions when the system starts empty. To address this issue, we propose a solution called transient staffing, which involves providing appointment times for agents to ensure that the expected queue length remains below a certain threshold. We model the system as a transient Erlang-A queue. To compute the appointment times, we employ a uniformized approximation that discretizes the elapsed time, which can be made as accurate as desired. We prove that the appointment times decrease with the arrival rate and traffic intensity, while increasing with the abandonment rate. Through numerical investigations, we find that adopting a transient staffing strategy leads to substantial cost savings, especially in scenarios where demand is high, customers are patient, traffic intensity is low, and the service level objective is intermediate. Furthermore, we use a fluid approximation to derive closed-form expressions for the agents' appointment times, and prove the impact of the system parameters. We show that this approximation performs well in predicting the first appointment times in contexts with high demand, low traffic intensity, and lax service level objective. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Data-mining of In-Situ TEM Experiments: on the Dynamics of Dislocations in CoCrFeMnNi Alloys

Author

Zhang, Chen, Song, Hengxu, Oliveros, Daniela, Fraczkiewicz, Anna, Legros, Marc, and Sandfeld, Stefan

Subjects
Condensed Matter - Materials Science
Abstract

High entropy alloys are a class of materials with many significant improvements in terms of mechanical properties as compared to ``classical'' alloys. The corresponding structure-property relations are not yet entirely clear, but it is commonly believed that the good mechanical performance is strongly related to dislocation interactions with the complex energy landscape formed due to alloying. Although in-situ Transmission Electron Microscopy (TEM) allows high-resolution studies of the structure and dynamics of moving dislocations and makes the local obstacle/energy ``landscape'' directly visible in the geometry of dislocations; such observation, however, are merely qualitative, and detailed three-dimensional analyses of the interaction between dislocations and the energy landscape is still missing. In this work, we utilized dislocations as ``probes'' for the local energy maxima which play the role of pinning points for the dislocation movement. To this end, we developed a unique data-mining approach that can perform coarse-grained spatio-temporal analysis, making ensemble averaging of a considerable number of snapshots possible. We investigate the effect of pinning points on the dislocation gliding behavior of CoCrFeMnNi alloy during in-situ TEM straining and find that (i) the pinning point strength changes when dislocations glide through and (ii) the pinning point moves along the direction close to the Burgers vector direction. Our data-mining method can be applied to dislocation motion in general, making it a useful tool for dislocation research.

Published
2022

25. A new method to construct high-dimensional copulas with Bernoulli and Coxian-2 distributions

Author

Blier-Wong, Christopher, Cossette, Hélène, Legros, Sébastien, and Marceau, Etienne

Subjects
Mathematics - Statistics Theory
Abstract

We propose an approach to construct a new family of generalized Farlie-Gumbel-Morgenstern (GFGM) copulas that naturally scales to high dimensions. A GFGM copula can model moderate positive and negative dependence, cover different types of asymmetries, and admits exact expressions for many quantities of interest such as measures of association or risk measures in actuarial science or quantitative risk management. More importantly, this paper presents a new method to construct high-dimensional copulas based on mixtures of power functions, and may be adapted to more general contexts to construct broader families of copulas. We construct a family of copulas through a stochastic representation based on multivariate Bernoulli distributions and Coxian-2 distributions. This paper will cover the construction of a GFGM copula, study its measures of multivariate association and dependence properties. We explain how to sample random vectors from the new family of copulas in high dimensions. Then, we study the bivariate case in detail and find that our construction leads to an asymmetric modified Huang-Kotz FGM copula. Finally, we study the exchangeable case and provide some insights into the most negative dependence structure within this new class of high-dimensional copulas.

Published
2022

28. Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study

Author

Zarbock, Alexander, Weiss, Raphael, Albert, Felix, Rutledge, Kristen, Kellum, John A., Bellomo, Rinaldo, Grigoryev, Evgeny, Candela-Toha, Angel M., Demir, Z. Aslı, Legros, Vincent, Rosenberger, Peter, Galán Menéndez, Patricia, Garcia Alvarez, Mercedes, Peng, Ke, Léger, Maxime, Khalel, Wegdan, Orhan-Sungur, Mukadder, and Meersch, Melanie

Published
2023
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30. The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells

Author

Maureen Ritter, Lola Canus, Anupriya Gautam, Thomas Vallet, Li Zhong, Alexandre Lalande, Bertrand Boson, Apoorv Gandhi, Sergueï Bodoirat, Julien Burlaud-Gaillard, Natalia Freitas, Philippe Roingeard, John N. Barr, Vincent Lotteau, Vincent Legros, Cyrille Mathieu, François-Loïc Cosset, and Solène Denolly

Subjects
Science
Abstract

Abstract The Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging pathogen of the Orthonairovirus genus that can cause severe and often lethal hemorrhagic diseases in humans. CCHFV has a broad tropism and can infect a variety of species and tissues. Here, by using gene silencing, blocking antibodies or soluble receptor fragments, we identify the low-density lipoprotein receptor (LDL-R) as a CCHFV entry factor. The LDL-R facilitates binding of CCHFV particles but does not allow entry of Hazara virus (HAZV), another member of the genus. In addition, we show that apolipoprotein E (apoE), an exchangeable protein that mediates LDL/LDL-R interaction, is incorporated on CCHFV particles, though not on HAZV particles, and enhances their specific infectivity by promoting an LDL-R dependent entry. Finally, we show that molecules that decrease LDL-R from the surface of target cells could inhibit CCHFV infection. Our study highlights that CCHFV takes advantage of a lipoprotein receptor and recruits its natural ligand to promote entry into cells.

Published
2024
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31. Thresholds and mechanisms of human magnetophosphene perception induced by low frequency sinusoidal magnetic fields

Author

Alexandre Legros, Janita Nissi, Ilkka Laakso, Joan Duprez, Robert Kavet, and Julien Modolo

Subjects
Extremely low-frequency magnetic fields, Power-line frequency magnetic fields, Magnetophosphenes, Human, Electroencephalography, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Virtually everyone is exposed to power-frequency MF (50/60 Hz), inducing in our body electric fields and currents, potentially modulating brain function. MF-induced electric fields within the central nervous system can generate flickering visual perceptions (magnetophosphenes), which form the basis of international MF exposure guidelines and recommendations protecting workers and the general public. However, magnetophosphene perception thresholds were estimated 40 years ago in a small, unreplicated study with significant uncertainties and leaving open the question of the involved interaction site. Methods: We used a stimulation modality termed transcranial alternating magnetic stimulation (tAMS), delivering in situ sinusoidal electric fields comparable to transcranial alternating current stimulation (tACS). Magnetophosphene perception was quantified in 81 volunteers exposed to MF (eye or occipital exposure) between 0 and 50 mT at frequencies of 20, 50, 60 and 100 Hz. Results: Reliable magnetophosphene perception was induced with tAMS without any scalp sensation, a major advantage as compared to tACS. Frequency-dependent thresholds were quantified using binary logistic regressions hence allowing to establish condition dependent probabilities of perception. Results support an interaction between induced current density and retinal rod cells. Conclusion: Beyond fundamental and immediate implications for international safety guidelines, and for identifying the interaction site underlying phosphene perception (ubiquitous in tACS experiments), our results support exploring the potential of tAMS for the differential diagnosis of retinal disorders and neuromodulation therapy.

Published
2024
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32. Oxydation des huiles de bases minérales d'origine pétrolière. Relation entre leur composition chimique, l'épaississement et la composition de leur produits de dégradation Oxidation of Mineral Base Stocks of Petroleum Origin. Relationship Between Chemical Composition, Thickening and Oxidized Degradation Products

Author

Faure D., Maleville X., Hipeaux J. C., and Legros A.

Subjects
Chemical technology, TP1-1185, Energy industries. Energy policy. Fuel trade, HD9502-9502.5
Abstract

Cette étude est basée sur la compréhension des problèmes liés à l'oxydation à haute température des huiles de base utilisées dans la formulation des lubrifiants pour moteurs automobiles. Les huiles étudiées sont d'origines différentes : huile Moyen-Orient et huile mer du Nord, respectivement à fortes et faibles teneurs en composés aromatiques et en soufre, huile hydroisomérisée et polyalphaoléfine, exemptes de ces composés, et huile hydrocraquée de composition intermédiaire. L'influence de la teneur et de la composition en produits aromatiques et en soufre des huiles sur la dégradation thermo-oxydante est montrée. Ces composés protègent naturellement les huiles de base contre l'oxydation, mais deviennent des précurseurs de dépôts dans des conditions d'oxydation sévères, en présence d'un catalyseur, tel le fer, qui est toujours présent dans un moteur. L'action des additifs antioxydants, inhibiteurs radicalaires et décomposeurs d'hydroperoxydes, est étudiée à l'aide d'essais d'oxydation en couche mince et en volume. Les produits d'oxydation sont identifiés, ce qui a permis d'améliorer la connaissance des processus de dégradation des composés en cours d'oxydation, et de montrer l'influence de ces processus sur la formation d'espèces oxydées volatiles, l'augmentation de la viscosité de l'huile et la formation d'espèces oxydées de haute masse molaire qui, en se condensant, participent à la formation de composés insolubles et de dépôts. This survey is based on an understanding of problems linked to the high-temperature oxidation of base stocks used for the formulation of lubricants for automotive engines. The oils investigated are of different origins : Middle East (MO) and the North Sea (MDN), which respectively have high and low aromatics and sulfur contents, hydroisomerized oil (HYDI) and polyalphaolefins (PA06), which are exempt from these compounds, and hydrocracked oil (HYDC), which has an intermediate composition (Table 1). By tests during which the amount of oxygen consumed is controled continuously (IFP OXYTEST, modified TFOUT) and by differential scanning calorimetry analysis (DSC), we have investigated the behavior of these different base stocks with regard to oxidation. Mineral base stocks with high contents of aromatics compounds and sulfur are partially and naturally protected against oxidation. The same is not true for hydroisomerized base stocks, which contain no natural inhibitor and so are very easily oxidized (Fig. 2). However, all such oils become oxidized quickly as soon as they are subjected to high temperatures in the presence of air or oxygen and an oxidation catalyzing metal (Fig. 3). In the presence of soluble iron salts used as catalysts, we havefound that, to be partially selfprotected against oxidation, a base stock must contain a minimum of aromatic carbons (CA > ou = 5 %) and sulfur (S > ou = 0. 5 %), with this sulfur generally being linked to aromatic compounds in the thiophenic form (Fig. 4). We will also show that, whereas the oxidation of a base stock issuing from refining products causes an increase in the viscosity of this base stock, this increase is linked directly to the amount of oxygen consumed and depends solely on this amount, no matter what the antioxidant additive may be or the amount of catalyst present. For a given amount of oxygen consumed, the variation in viscosity is independent of the temperature and duration of oxidation as well as of the concentration and choice of the antioxidant (Table 3, Figs. 5 and 6). The antioxidant properties of natural sulfur-containing aromatic compounds have been demonstrated by incorporating them in polyalphaolefin PA06 after they have been extracted from MO and MDN oils and by studying the oxidation stability of the mixtures thus obtained by thin-layer oxidation by DSC (Table 5). Whereas PA06 has no natural resistance to oxidation, the addition of aromatic compounds coming from MO and MDN oils give this base stock an oxidation stability directly linked with the amount and composition of the sulfur-containing aromatic compounds added (Tables 6 and 7, Figs. 7 to 11). Paradoxically, such natural inhibitors present in base stocks become precursors of deposits when these oils are subjected to severe oxidation conditions. These sulfur-containing aromatic inhibitors react themselves according to a process involving the association of sulfur-containing molecules. This process leads to an increase in viscosity and the formation of insoluble compounds (Table 10 and Fig. 20). These insoluble compounds are not detected with saturated base stocks such as PA06 or HYDI. The antioxydant effect of the radical-inhibitor and hydroperoxide-decomposer types has also been investigated, for each type of additive (Table 9 and Figs. 12 to 17) then together with synergism phenomena among such products (Figs. 18 and 19). By using high-performance analytical techniques (GC/MS, GC, 13C NMR, IR spectroscopy, SEM, etc. ), we have step by step, characterized the degradation products formed during oxidation, i. e. volatile products, liquid products and insoluble products (Table 17). All compounds polar products contained in these three components of oxidized oil are made up of hydroxyl, carbonyl and carboxyl species :- The volatile products that we condensed when cooled (- 80°C) are made up of a main aqueous phase and a supernatent organic phase (Table 12). These two phases contain nonsulfur-containing linear oxygenated constituents, alkanes as well as cyclical oxygenated components (lactones) and aromatics. The aromatic components are found solely in volatile products issuing from MO and MDN mineral base stocks (Tables 13 to 16). These products have a lower molar mass than that of base stocks and stem from the oxidation of hydrocarbons, from the oxidation and reactions of the recombination of oxidized products themselved and from termination reactions. Heavy soluble products are composed of species that may be divided into two categories (Tables 18 and 19) :- Nondialyzable products with oxygen contents of about 10 to 12 % and, for MO oil, 1. 3% sulfur. They have a average molar mass of around 1,000 g/mol and stem mainly from the oxidation of aromatic compounds contained in mineral oils. - Dialyzable products with molar masses always greater than those of the base stocks (400 to 500 g/mol) and oxygen contents of between 1. 8 and 3. 9% mass. The increase in the average molecular mass of oxidized compounds and their aromatics content is determined by steric exclusion chromatography with both ultraviolet and differential refractometric detections (Figs. 23 and 24). The insoluble products, whether in suspension inside the oil or deposited on the walls of the oxidation reactor, have been identified by scanning electron microscopy and by 13 C NMR. - They appear in the form of spherical clusters, with a size between 0. 1 and 8 µm depending on the oxidation conditions. They are rich in oxygen (20%) and concentrate the aromatic compounds and sulfur comingfromthe basestock. For example,the insolubles coming from MO oil contain 17. 5% CA compared to 9% in the initial oil. Their average molecular masses also depend on the initial CA and sulfur contents of the base stock and are between 1600 and 2300 g/mol (Table 20 and Figs. 25 and 26). This undeniably demonstrates that the presence of these sulfur-bearing aromatic compounds contributes in the formation of insoluble products during oxidation. Therefore, with regard to problems linked to oxidation and the formation of insoluble products, it seems desirable to formulate motor oil from base stocks that have undergone severe processing to remove sulfur-oontaining aromatic compounds such as the ones they naturally contain, and to reinforce their oxidation resistance by choosing a suitable combination of additives.

Published
2006
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33. Surface transfer coefficients estimation for heat conduction problem using the Bayesian framework

Author

Berger, Julien and Legros, Clemence

Subjects
Computer Science - Computational Engineering, Finance, and Science
Abstract

This work deals with an inverse two-dimensional nonlinear heat conduction problem to determine the top and lateral surface transfer coefficients. For this, the \textsc{B}ayesian framework with the \textsc{M}arkov Chain \textsc{M}onte \textsc{C}arlo algorithm is used to determine the posterior distribution of unknown parameters. To handle the computational burden, a lumped one-dimensional model is proposed. The lumped model approximations are considered within the parameter estimation procedure thanks to the Approximation Error Model. The experiments are carried out for several configurations of chamber ventilator speed. Experimental observations are obtained through a complete measurement uncertainty propagation. By solving the inverse problem, accurate probability distributions are determined. Additional investigations are performed to demonstrate the reliability of the lumped model, in terms of accuracy and computational gains.

Published
2022
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34. The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly

Author

Anupriya Gautam, Alexandre Lalande, Maureen Ritter, Natalia Freitas, Solène Lerolle, Lola Canus, Fouzia Amirache, Vincent Lotteau, Vincent Legros, François-Loïc Cosset, Cyrille Mathieu, and Bertrand Boson

Subjects
CCHFV, assembly, trafficking, glycoprotein, nucleoprotein, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface glycoproteins (GP), Gn and Gc, that are released by processing of a glycoprotein precursor complex whose maturation takes place in the ER and is completed through the secretion pathway. Here, we characterized the trafficking network exploited by CCHFV GPs during viral assembly, envelopment, and/or egress. We identified membrane trafficking motifs in the cytoplasmic domains (CD) of CCHFV GPs and addressed how they impact these late stages of the viral life cycle using infection and biochemical assays, and confocal microscopy in virus-producing cells. We found that several of the identified CD motifs modulate GP transport through the retrograde trafficking network, impacting envelopment and secretion of infectious particles. Finally, we identified PACS-2 as a crucial host factor contributing to CCHFV GPs trafficking required for assembly and release of viral particles.

Published
2024
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35. Unlocking the power of LiOH: Key to next-generation ultra-compact thermal energy storage systems

Author

F. Achchaq, S.-C. Moon, and P. Legros

Subjects
Alkali metal hydroxide, PCM, Enthalpy-temperature function, Softening, Anisotropy, Thermal property, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

This study explores the potential of untapped lithium hydroxide (LiOH) as a phase change material for thermal energy storage. By overcoming the challenges associated with the liquid LiOH leakage, we successfully thermal-cycled LiOH in a laboratory scale experimentation, and observed its stability (>500 thermal cycles), without chemical decomposition. This step has never been performed to date. Its solid-to-liquid reversible transitions temperatures and related solidification/melting enthalpies values have been verified. Then, the first experimental characterization of LiOH's thermal properties shows unexpected values for its heat capacity, thermal conductivity and diffusivity, in contradiction with the few ones available in literature. This opens avenues for LiOH's applications for the storage of sensible and latent heat, as shown through the increased cycle efficiency potential of a thermal energy storage system if based on its energy storage capacity; up to six times more volumetric energy density compared to traditional Solar Salt-based systems used in the solar tower plant (4.5 GJ/m3 vs. 0.76 GJ/m3 over 1000 thermal cycles). Additionally, we observed a softening phenomenon that occurs inconsistently during heating, but which may account for its excellent melting properties and the interplay with other raw chemicals. This new insight contributes certainly to the underlying mechanisms in the synthesis of another promising heat storage material in development: the peritectic compound Li4Br(OH)3. This pioneering work suggests LiOH as a promising ultra-compact thermal energy storage material for filling the intermediary gap from current to next-generation solar power plants, although its large-scale application requires further investigation to achieve economic viability.

Published
2024
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36. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Author

Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Clifton L. Dalgard, Shen-Ying Zhang, Qian Zhang, Christopher Chiu, Jacques Fellay, Joseph J. Grzymski, Vanessa Sancho-Shimizu, Laurent Abel, Jean-Laurent Casanova, Aurélie Cobat, Alexandre Bolze, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Giorgio Casari, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Stefan N. Constantinescu, Megan A. Cooper, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Carlos Flores, José Luis Franco, Antoine Froidure, Peter K. Gregersen, Bodo Grimbacher, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Elena W.Y. Hsieh, Eystein Husebye, Kohsuke Imai, Yuval Itan, Emmanuelle Jouanguy, Elżbieta Kaja, Timokratis Karamitros, Kai Kisand, Cheng-Lung Ku, Yu-Lung Lau, Yun Ling, Carrie L. Lucas, Tom Maniatis, Davood Mansouri, László Maródi, France Mentré, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine H. Mogensen, Tomohiro Morio, Lisa F.P. Ng, Luigi D. Notarangelo, Antonio Novelli, Giuseppe Novelli, Cliona O'Farrelly, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarström, Jean W. Pape, Rebeca Perez de Diego, Jordi Perez-Tur, David S. Perlin, Graziano Pesole, Anna M. Planas, Carolina Prando, Aurora Pujol, Anne Puel, Lluis Quintana-Murci, Sathishkumar Ramaswamy, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Anna Sediva, Mikko R.J. Seppänen, Mohammad Shahrooei, Anna Shcherbina, Ondrej Slaby, Andrew L. Snow, Pere Soler-Palacín, Vassili Soumelis, Ivan Tancevski, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Pierre Tiberghien, Sophie Trouillet-Assant, Stuart E. Turvey, K. M. Furkan Uddin, Mohammed J. Uddin, Diederik van de Beek, Donald C. Vinh, Horst von Bernuth, Joost Wauters, Mayana Zatz, Pawel Zawadzki, Serge Bureau, Yannick Vacher, Anne Gysembergh-Houal, Lauren Demerville, Abla Benleulmi-Chaachoua, Sebastien Abad, Radhiya Abassi, Abdelrafie Abdellaoui, Abdelkrim Abdelmalek, Hendy Abdoul, Helene Abergel, Fariza Abeud, Sophie Abgrall, Noemie Abisror, Marylise Adechian, Nordine Aderdour, Hakeem Farid Admane, Frederic Adnet, Sara Afritt, Helene Agostini, Claire Aguilar, Sophie Agut, Tommaso Francesco Aiello, Marc Ait Kaci, Hafid Ait Oufella, Gokula Ajeenthiravasan, Virginie Alauzy, Fanny Alby-Laurent, Lucie Allard, Marie-Alexandra Alyanakian, Blanca Amador Borrero, Sabrina Amam, Lucile Amrouche, Marc Andronikof, Dany Anglicheau, Nadia Anguel, Djillali Annane, Mohammed Aounzou, Caroline Aparicio, Gladys Aratus, Jean-Benoit Arlet, Jeremy Arzoine, Elisabeth Aslangul, Mona Assefi, Adeline Aubry, Laetitia Audiffred, Etienne Audureau, Christelle Nathalie Auger, Jean-Charles Auregan, Celine Awotar, Sonia Ayllon Milla, Delphine Azan, Laurene Azemar, Billal Azzouguen, Marwa Bachir Elrufaai, Aïda Badsi, Prissile Bakouboula, Coline Balcerowiak, Fanta Balde, Elodie Baldivia, Eliane-Flore Bangamingo, Amandine Baptiste, Fanny Baran-Marszak, Caroline Barau, Nathalie Barget, Flore Baronnet, Romain Barthelemy, Jean-Luc Baudel, Camille Baudry, Elodie Baudry, Laurent Beaugerie, Adel Belamri, Nicolas Belaube, Rhida Belilita, Pierre Bellassen, Rawan Belmokhtar, Isabel Beltran, Ruben Benainous, Mourad Benallaoua, Robert Benamouzig, Amélie Benbara, Jaouad Benhida, Anis Benkhelouf, Jihene Benlagha, Chahinez Benmostafa, Skander Benothmane, Miassa Bentifraouine, Laurence Berard, Quentin Bernier, Enora Berti, Astrid Bertier, Laure Berton, Simon Bessis, Alexandra Beurton, Celine Bianco, Clara Bianquis, Frank Bidar, Philippe Blanche, Clarisse Blayau, Alexandre Bleibtreu, Emmanuelle Blin, Coralie Bloch-Queyrat, Marie-Christophe Boissier, Diane Bollens, Marion Bolzoni, Rudy pierre Bompard, Nicolas Bonnet, Justine Bonnouvrier, Shirmonecrystal Botha, Wissam Boucenna, Fatiha Bouchama, Olivier Bouchaud, Hanane Bouchghoul, Taoueslylia Boudjebla, Noel Boudjema, Catherine Bouffard, Adrien Bougle, Meriem Bouguerra, Leila Bouras, Agnes Bourcier, Anne Bourgarit Durand, Anne Bourrier, Fabrice Bouscarat, Diane Bouvry, Nesrine Bouziri, Ons Bouzrara, Sarah Bribier, Delphine Brugier, Melanie Brunel, Eida Bui, Anne Buisson, Iryna Bukreyeva, Côme Bureau, Jacques Cadranel, Johann Cailhol, Ruxandra Calin, Clara Campos Vega, Pauline Canavaggio, Marta Cancella, Delphine Cantin, Albert Cao, Lionel Carbillon, Nicolas Carlier, Clementine Cassard, Guylaine Castor, Marion Cauchy, Olivier Cha, Benjamin Chaigne, Salima Challal, Karine Champion, Patrick Chariot, Julie Chas, Simon Chauveau, Anthony Chauvin, Clement Chauvin, Nathalie Chavarot, Kamélia Chebbout, Mustapha Cherai, Ilaria Cherubini, Amelie Chevalier, Thibault Chiarabini, Thierry Chinet, Richard Chocron, Pascaline Choinier, Juliette Chommeloux, Christophe Choquet, Laure Choupeaux, Benjamin Chousterman, Dragosmarius Ciocan, Ada Clarke, Gaëlle Clavere, Florian Clavier, Karine Clement, Sebastien Clerc, Yves Cohen, Fleur Cohen, Adrien Cohen, Audrey Coilly, Hester Colboc, Pauline Colin, Magalie Collet, Chloé Comarmond, Emeline Combacon, Alain Combes, Celine Comparon, Jean-Michel Constantin, Hugues Cordel, Anne-Gael Cordier, Adrien Costantini, Nathalie Costedoat Chalumeau, Camille Couffignal, Doriane Coupeau, Alain Creange, Yannie Cuvillier Lamarre, Charlène Da Silveira, Sandrine Dautheville Guibal El Kayani, Nathalie De Castro, Yann De Rycke, Lucie Del Pozo, Quentin Delannoy, Mathieu Delay, Robin Deleris, Juliette Delforge, Laëtitia Delphine, Noemie Demare, Sophie Demeret, Alexandre Demoule, Aurore Deniau, François Depret, Sophie Derolez, Ouda Derradji, Nawal Derridj, Vincent Descamps, Lydia Deschamps, Celine Desconclois, Cyrielle Desnos, Karine Desongins, Robin Dhote, Benjamin Diallo, Morgane Didier, Myriam Diemer, Stephane Diez, Juliette Djadi-Prat, Fatima-Zohra Djamouri Monnory, Siham Djebara, Naoual Djebra, Minette Djietcheu, Hadjer Djillali, Nouara Djouadi, Severine Donneger, Catarina Dos Santos, Nathalie Dournon, Martin Dres, Laura Droctove, Marie Drogrey, Margot Dropy, Elodie Drouet, Valérie Dubosq, Evelyne Dubreucq, Estelle Dubus, Boris Duchemann, Thibault Duchenoy, Emmanuel Dudoignon, Romain Dufau, Florence Dumas, Clara Duran, Emmanuelle Duron, Antoine Durrbach, Claudine Duvivier, Nathan Ebstein, Jihane El Khalifa, Alexandre Elabbadi, Caroline Elie, Gabriel Ernotte, Anne Esling, Martin Etienne, Xavier Eyer, Muriel Sarah Fartoukh, Takoua Fayali, Marion Fermaut, Arianna Fiorentino, Souha Fliss, Marie-Céline Fournier, Benjamin Fournier, Hélène Francois, Olivia Freynet, Yvann Frigout, Isaure Fromont, Axelle Fuentes, Thomas Furet, Joris Galand, Marc Garnier, Agnes Gaubert, Stéphane Gaudry, Samuel Gaugain, Damien Gauthier, Maxime Gautier, Sophie Georgin-Lavialle, Daniela Geromin, Mohamed Ghalayini, Bijan Ghaleh, Myriam Ghezal, Aude Gibelin, Linda Gimeno, Benoit Girard, Bénédicte Giroux Leprieur, Doryan Gomes, Elisabete Gomes-Pires, Anne Gouge, Amel Gouja, Helene Goulet, Sylvain Goupil, Jeanne Goupil De Bouille, Julien Gras, Segolene Greffe, Lamiae Grimaldi, Paul Guedeney, Bertrand Guidet, Matthias Guillo, Mariechristelle Gulczynski, Tassadit Hadjam, Didier Haguenauer, Soumeya Hammal, Nadjib Hammoudi, Olivier Hanon, Anarole Harrois, Coraline Hautem, Guillaume Hekimian, Nicholas Heming, Olivier Hermine, Sylvie Ho, Marie Houllier, Benjamin Huot, Tessa Huscenot, Wafa Ibn Saied, Ghilas Ikherbane, Meriem Imarazene, Patrick Ingiliz, Lina Iratni, Stephane Jaureguiberry, Jean-Francois Jean-Marc, Deleena Jeyarajasingham, Pauline Jouany, Veronique Jouis, Clement Jourdaine, Ouifiya Kafif, Rim Kallala, Sandrine Katsahian, Lilit Kelesyan, Vixra Keo, Flora Ketz, Warda Khamis, Enfel Khelili, Mehdi Khellaf, Christy Gaëlla Kotokpo Youkou, Ilias Kounis, Gaelle Kpalma, Jessica Krause, Vincent Labbe, Karine Lacombe, Jean-Marc Lacorte, Anne Gaelle Lafont, Emmanuel Lafont, Lynda Lagha, Lionel Lamhaut, Aymeric Lancelot, Cecilia Landman, Fanny Lanternier, Cecile Larcheveque, Caroline Lascoux Combe, Ludovic Lassel, Benjamin Laverdant, Christophe Lavergne, Jean-Rémi Lavillegrand, Pompilia Lazureanu, Loïc Le Guennec, Lamia Leberre, Claire Leblanc, Marion Leboyer, Francois Lecomte, Marine Lecorre, Romain Leenhardt, Marylou Lefebvre, Bénédicte Lefebvre, Paul Legendre, Anne Leger, Laurence Legros, Justyna Legrosse, Sébastien Lehuunghia, Julien Lemarec, Jeremie Leporrier-Ext, Manon Lesein, Hubert Lesur, Vincent Levy, Albert Levy, Edwige Lopes, Amanda Lopes, Vanessa Lopez, Julien Lopinto, Olivier Lortholary, Badr Louadah, Bénédicte Loze, Marie-Laure Lucas, Axelle Lucasamichi, Liem Binh Luong, Arouna Magazimama-Ext, David Maingret, Lakhdar Mameri, Philippe Manivet, Cylia Mansouri, Estelle Marcault, Jonathan Marey, Nathalie Marin, Clémence Marois, Olivier Martin, Lou Martineau, Cannelle Martinez-Lopez, Pierre Martyniuck, Pauline Mary De Farcy, Nessrine Marzouk, Rafik Masmoudi, Alexandre Mebazaa, Frédéric Mechai, Fabio Mecozzi, Chamseddine Mediouni, Bruno Megarbane, Mohamed Meghadecha, Élodie Mejean, Arsene Mekinian, Nour Mekki Abdelhadi, Rania Mekni, Thinhinan Sabrina Meliti, Breno Melo Lima, Paris Meng, Soraya Merbah, Fadhila Messani, Yasmine Messaoudi, Baboo-Irwinsingh Mewasing, Lydia Meziane, Carole Michelot-Burger, Françoise Mignot, Fadi Hillary Minka, Makoto Miyara, Pierre Moine, Jean-Michel Molina, Anaïs Montegnies-Boulet, Alexandra Monti, Claire Montlahuc, Anne-Lise Montout, Alexandre Moores, Caroline Morbieu, Helene Mortelette, Stéphane Mouly, Rosita Muzaffar, Cherifa Iness Nacerddine, Marine Nadal, Hajer Nadif, Kladoum Nassarmadji, Pierre Natella, Sandrine Ndingamondze, Stefan Neraal, Caroline Nguyen, Bao N'Guyen, Isabelle Nion Larmurier, Luc Nlomenyengue, Nicolas Noel, Hilario Nunes, Edris Omar, Zineb Ouazene, Elise Ouedraogo, Wassila Ouelaa, Anissa Oukhedouma, Yasmina Ould Amara, Herve Oya, Johanna Oziel, Thomas Padilla, Elena Paillaud, Solenne Paiva, Beatrice Parfait, Perrine Parize, Christophe Parizot, Antoine Parrot, Arthur Pavot, Laetitia Peaudecerf, Frédéric Pene, Marion Pepin, Julie Pernet, Claire Pernin, Mylène Petit, Olivier Peyrony, Marie-Pierre Pietri, Olivia Pietri, Marc Pineton De Chambrun, Michelle Pinson, Claire Pintado, Valentine Piquard, Christine Pires, Benjamin Planquette, Sandrine Poirier, Anne-Laure Pomel, Stéphanie Pons, Diane Ponscarme, Annegaelle Pourcelot, Valérie Pourcher, Anne Pouvaret, Florian Prever, Miresta Previlon, Margot Prevost, Marie-Julie Provoost, Cyril Quemeneur, Cédric Rafat, Agathe Rami, Brigitte Ranque, Maurice Raphael, Jean Herle Raphalen, Anna Rastoin, Mathieu Raux, Amani Rebai, Michael Reby, Alexis Regent, Asma Regrag, Matthieu Resche-Rigon, Quentin Ressaire, Christian Richard, Mariecaroline Richard, Maxence Robert, Benjamin Rohaut, Camille Rolland-Debord, Jacques Ropers, Anne-Marie Roque-Afonso, Charlotte Rosso, Mélanie Rousseaux, Nabila Rousseaux, Swasti Roux, Lorène Roux, Claire Rouzaud, Antoine Rozes, Emma Rubenstein, Jean-Marc Sabate, Sheila Sabet, Sophie-Caroline Sacleux, Nathalie Saidenberg Kermanach, Faouzi Saliba, Dominique Salmon, Laurent Savale, Guillaume Savary, Rebecca Sberro, Anne Scemla, Frederic Schlemmer, Mathieu Schwartz, Saïd Sedfi, Samia Sefir-Kribel, Philippe Seksik, Pierre Sellier, Agathe Selves, Nicole Sembach, Luca Semerano, Marie-Victoire Senat, Damien Sene, Alexandra Serris, Lucile Sese, Naima Sghiouar, Johanna Sigaux, Martin Siguier, Johanne Silvain, Noémie Simon, Tabassome Simon, Lina Innes Skandri, Miassa Slimani, Aurélie Snauwaert, Harry Sokol, Heithem Soliman, Nisrine Soltani, Benjamin Soyer, Gabriel Steg, Lydia Suarez, Tali-Anne Szwebel, Kossi Taffame, Yacine Tandjaoui-Lambiotte, Claire Tantet, Mariagrazia Tateo, Igor Theodose, Pierre clement Thiebaud, Caroline Thomas, Kelly Tiercelet, Julie Tisserand, Carole Tomczak, Krystel Torelino, Fatima Touam-Ext, Lilia Toumi, Gustave Toury, Mireille Toy-Miou, Olivia Tran Dinh Thanh Lien, Alexy Trandinh, Jean-Marc Treluyer, Baptiste Trinque, Jennifer Truchot, Sarah Tubiana, Simone Tunesi, Matthieu Turpin, Agathe Turpin, Tomas Urbina, Rafael Usubillaga Narvaez, Yurdagul Uzunhan, Prabakar Vaittinadaayar, Arnaud Valent, Maelle Valentian, Nadia Valin, Hélène Vallet, Marina Vaz, Miguel-Alejandro Vazquezibarra, Benoit Vedie, Laetitia Velly, Celine Verstuyft, Cedric Viallette, Eric Vicaut, Dorothee Vignes, Damien Vimpere, Myriam Virlouvet, Guillaume Voiriot, Lena Voisot, Emmanuel Weiss, Nicolas Weiss, Anaïs Winchenne, Youri Yordanov, Lara Zafrani, Mohamad Zaidan, Wissem Zaidi, Cathia Zak, Aida Zarhrate-Ghoul, Ouassila Zatout, Suzanne Zeino, Michel Zeitouni, Naïma Zemirli, Lorene Zerah, Ounsa Zia, Marianne Ziol, Oceane Zolario, Julien Zuber, Claire Andrejak, François Angoulvant, Delphine Bachelet, Marie Bartoli, Romain Basmaci, Sylvie Behillil, Marine Beluze, Dehbia Benkerrou, Krishna Bhavsar, Lila Bouadma, Sabelline Bouchez, Maude Bouscambert, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chirouze, Alexandra Coelho, Sandrine Couffin-Cadiergues, Eric d’Ortenzio, Marie-Pierre Debray, Laurene Deconinck, Dominique Deplanque, Diane Descamps, Mathilde Desvallée, Alpha Diallo, Alphonsine Diouf, Céline Dorival, François Dubos, Brigitte Elharrar, Vincent Enouf, Hélène Esperou, Marina Esposito-Farese, Manuel Etienne, Eglantine Ferrand Devouge, Nathalie Gault, Alexandre Gaymard, Tristan Gigante, Morgane Gilg, Jérémie Guedj, Alexandre Hoctin, Isabelle Hoffmann, Ikram Houas, Jean-Sébastien Hulot, Salma Jaafoura, Florentia Kaguelidou, Sabrina Kali, Antoine Khalil, Coralie Khan, Cédric Laouénan, Samira Laribi, Minh Le, Quentin Le Hingrat, Soizic Le Mestre, Hervé Le Nagard, François-Xavier Lescure, Sophie Letrou, Yves Levy, Bruno Lina, Guillaume Lingas, Jean-Christophe Lucet, Denis Malvy, Marina Mambert, Amina Meziane, Hugo Mouquet, Jimmy Mullaert, Nadège Neant, Duc Nguyen, Marion Noret, Saad Nseir, Aurélie Papadopoulos, Christelle Paul, Nathan Peiffer-Smadja, Thomas Perpoint, Ventzislava Petrov-Sanchez, Gilles Peytavin, Huong Pham, Olivier Picone, Oriane Puéchal, Christian Rabaud, Manuel Rosa-Calatrava, Bénédicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Richa Su, Coralie Tardivon, Marie-Capucine Tellier, François Téoulé, Olivier Terrier, Jean-François Timsit, Christelle Tual, Sylvie Van Der Werf, Noémie Vanel, Aurélie Veislinger, Benoit Visseaux, Aurélie Wiedemann, Yazdan Yazdanpanah, Loubna Alavoine, Charlotte Charpentier, Aline Dechanet, Jean-Luc Ecobichon, Wahiba Frezouls, Nadhira Houhou, Jonathan Lehacaut, Pauline Manchon, Mariama Nouroudine, Caroline Quintin, Michael Thy, Sylvie van der Werf, Valérie Vignali, Abir Chahine, Nawal Waucquier, Maria-Claire Migaud, Félix Djossou, Mayka Mergeay-Fabre, Aude Lucarelli, Magalie Demar, Léa Bruneau, Patrick Gérardin, Adrien Maillot, Christine Payet, Bruno Laviolle, Fabrice Laine, Christophe Paris, Mireille Desille-Dugast, Julie Fouchard, Thierry Pistone, Pauline Perreau, Valérie Gissot, Carole L.E. Goas, Samatha Montagne, Lucie Richard, Kévin Bouiller, Maxime Desmarets, Alexandre Meunier, Marilou Bourgeon, Benjamin Lefévre, Hélène Jeulin, Karine Legrand, Sandra Lomazzi, Bernard Tardy, Amandine Gagneux-Brunon, Frédérique Bertholon, Elisabeth Botelho-Nevers, Christelle Kouakam, Leturque Nicolas, Layidé Roufai, Karine Amat, Hélène Espérou, Samia Hendou, Giuseppe Foti, Giuseppe Citerio, Ernesto Contro, Alberto Pesci, Maria Grazia Valsecchi, Marina Cazzaniga, Giacomo Bellani, Jorge Abad, Giulia Accordino, Micol Angelini, Sergio Aguilera-Albesa, Aina Aguiló-Cucurull, Esra Akyüz Özkan, Ilad Alavi Darazam, Jonathan Antonio Roblero Albisures, Juan C. Aldave, Miquel Alfonso Ramos, Taj Ali Khan, Anna Aliberti, Seyed Alireza Nadji, Gulsum Alkan, Suzan A. AlKhater, Jerome Allardet-Servent, Luis M. Allende, Rebeca Alonso-Arias, Mohammed S. Alshahrani, Laia Alsina, Zahir Amoura, Arnau Antolí, Romain Arrestier, Mélodie Aubart, Teresa Auguet, Iryna Avramenko, Gökhan Aytekin, Axelle Azot, Seiamak Bahram, Fanny Bajolle, Fausto Baldanti, Aurélie Baldolli, Maite Ballester, Benoit Barrou, Federica Barzaghi, Sabrina Basso, Gulsum Iclal Bayhan, Liliana Bezrodnik, Agurtzane Bilbao, Geraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blázquez-Gamero, Marketa Bloomfield, Mireia Bolivar-Prados, Raphael Borie, Elisabeth Botdhlo-Nevers, Aurore Bousquet, David Boutolleau, Claire Bouvattier, Oksana Boyarchuk, Juliette Bravais, M. Luisa Briones, Marie-Eve Brunner, Raffaele Bruno, Maria Rita P. Bueno, Huda Bukhari, Jacinta Bustamante, Juan José Cáceres Agra, Ruggero Capra, Raphael Carapito, Maria Carrabba, Carlos Casasnovas, Marion Caseris, Irene Cassaniti, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus V. Castro, Emilie Catherinot, Jale Bengi Celik, Alessandro Ceschi, Martin Chalumeau, Bruno Charbit, Cécile Boulanger, Père Clavé, Bonaventura Clotet, Anna Codina, Cloé Comarmond, Patrizia Comoli, Angelo G. Corsico, Taner Coşkuner, Aleksandar Cvetkovski, Cyril Cyrus, David Dalmau, François Danion, David Ross Darley, Vincent Das, Nicolas Dauby, Stéphane Dauger, Paul De Munte, Loic de Pontual, Amin Dehban, Geoffroy Delplancq, Isabelle Desguerre, Antonio Di Sabatino, Jean-Luc Diehl, Stephanie Dobbelaere, Elena Domínguez-Garrido, Clément Dubost, Olov Ekwall, Şefika Elmas Bozdemir, Marwa H. Elnagdy, Melike Emiroglu, Akifumi Endo, Emine Hafize Erdeniz, Selma Erol Aytekin, Maria Pilar Etxart Lasa, Romain Euvrard, Giovanna Fabio, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernandez Arquero, Ricard Ferrer, Jose Ferreres, Bruno Francois, Victoria Fumadó, Kitty S.C. Fung, Francesca Fusco, Alenka Gagro, Blanca Garcia Solis, Pierre Garçon, Pascale Gaussem, Zeynep Gayretli, Juana Gil-Herrera, Laurent Gilardin, Audrey Giraud Gatineau, Mònica Girona-Alarcón, Karen Alejandra Cifuentes Godínez, Jean-Christophe Goffard, Nacho Gonzales, Luis I. Gonzalez-Granado, Rafaela González-Montelongo, Antoine Guerder, Belgin Gülhan, Victor Daniel Gumucio, Leif Gunnar Hanitsch, Jan Gunst, Marta Gut, Jérôme Hadjadj, Selda Hancerli, Tetyana Hariyan, Nevin Hatipoglu, Deniz Heppekcan, Elisa Hernandez-Brito, Po-ki Ho, María Soledad Holanda-Peña, Juan P. Horcajada, Sami Hraiech, Linda Humbert, Ivan F.N. Hung, Alejandro D. Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María Jesús Arranz, Marie-Thérèse Jimeno, Iolanda Jordan, Saliha Kanık-Yüksek, Yalcin Kara, Aydın Karahan, Adem Karbuz, Kadriye Kart Yasar, Ozgur Kasapcopur, Kenichi Kashimada, Sevgi Keles, Yasemin Kendir Demirkol, Yasutoshi Kido, Can Kizil, Ahmet Osman Kılıç, Adam Klocperk, Antonia Koutsoukou, Zbigniew J. Król, Hatem Ksouri, Paul Kuentz, Arthur M.C. Kwan, Yat Wah M. Kwan, Janette S.Y. Kwok, Jean-Christophe Lagier, David S.Y. Lam, Vicky Lampropoulou, Fleur Le Bourgeois, Yee-Sin Leo, Rafael Leon Lopez, Daniel Leung, Michael Levin, Michael Levy, Romain Lévy, Zhi Li, Daniele Lilleri, Edson Jose Adrian Bolanos Lima, Agnes Linglart, Eduardo López-Collazo, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Kwok-Cheung Lung, Charles-Edouard Luyt, David C. Lye, Cinthia Magnone, Enrico Marchioni, Carola Marioli, Majid Marjani, Laura Marques, Jesus Marquez Pereira, Andrea Martín-Nalda, David Martínez Pueyo, Javier Martinez-Picado, Iciar Marzana, Carmen Mata-Martínez, Alexis Mathian, Larissa R.B. Matos, Gail V. Matthews, Julien Mayaux, Raquel McLaughlin-Garcia, Philippe Meersseman, Jean-Louis Mège, Armand Mekontso-Dessap, Isabelle Melki, Federica Meloni, Jean-François Meritet, Paolo Merlani, Özge Metin Akcan, Mehdi Mezidi, Isabelle Migeotte, Maude Millereux, Matthieu Million, Tristan Mirault, Clotilde Mircher, Mehdi Mirsaeidi, Yoko Mizoguchi, Bhavi P. Modi, Francesco Mojoli, Elsa Moncomble, Abián Montesdeoca Melián, Antonio Morales Martinez, Francisco Morandeira, Pierre-Emmanuel Morange, Clémence Mordacq, Guillaume Morelle, Stéphane J. Mouly, Adrián Muñoz-Barrera, Cyril Nafati, Shintaro Nagashima, Yu Nakagama, Bénédicte Neven, João Farela Neves, Yuk-Yung Ng, Hubert Nielly, Yeray Novoa Medina, Esmeralda Nuñez Cuadros, Semsi Nur Karabela, J. Gonzalo Ocejo-Vinyals, Mehdi Oualha, Amani Ouedrani, Tayfun Özçelik, Aslinur Ozkaya-Parlakay, Michele Pagani, Maria Papadaki, Philippe Parola, Tiffany Pascreau, Stéphane Paul, Estela Paz-Artal, Sigifredo Pedraza, Nancy Carolina González Pellecer, Silvia Pellegrini, Rebeca Pérez de Diego, Xosé Luis Pérez-Fernández, Aurélien Philippe, Quentin Philippot, Adrien Picod, Marc Pineton de Chambrun, Antonio Piralla, Laura Planas-Serra, Dominique Ploin, Julien Poissy, Géraldine Poncelet, Garyphallia Poulakou, Marie S. Pouletty, Persia Pourshahnazari, Jia Li Qiu-Chen, Paul Quentric, Thomas Rambaud, Didier Raoult, Violette Raoult, Anne-Sophie Rebillat, Claire Redin, Léa Resmini, Pilar Ricart, Jean-Christophe Richard, Raúl Rigo-Bonnin, Nadia Rivet, Jacques G. Rivière, Gemma Rocamora-Blanch, Mathieu P. Rodero, Carlos Rodrigo, Luis Antonio Rodriguez, Carlos Rodriguez-Gallego, Agustí Rodriguez-Palmero, Carolina Soledad Romero, Anya Rothenbuhler, Damien Roux, Nikoletta Rovina, Flore Rozenberg, Yvon Ruch, Montse Ruiz, Maria Yolanda Ruiz del Prado, Juan Carlos Ruiz-Rodriguez, Joan Sabater-Riera, Kai Saks, Maria Salagianni, Oliver Sanchez, Adrián Sánchez-Montalvá, Silvia Sánchez-Ramón, Laire Schidlowski, Agatha Schluter, Julien Schmidt, Matthieu Schmidt, Catharina Schuetz, Cyril E. Schweitzer, Francesco Scolari, Luis Seijo, Analia Gisela Seminario, Piseth Seng, Sevtap Senoglu, Mikko Seppänen, Alex Serra Llovich, Virginie Siguret, Eleni Siouti, David M. Smadja, Nikaia Smith, Ali Sobh, Xavier Solanich, Jordi Solé-Violán, Catherine Soler, Betül Sözeri, Giulia Maria Stella, Yuriy Stepanovskiy, Annabelle Stoclin, Fabio Taccone, Jean-Luc Taupin, Simon J. Tavernier, Loreto Vidaur Tello, Benjamin Terrier, Guillaume Thiery, Karolina Thorn, Caroline Thumerelle, Imran Tipu, Martin Tolstrup, Gabriele Tomasoni, Julie Toubiana, Josep Trenado Alvarez, Vasiliki Triantafyllia, Jesús Troya, Owen T.Y. Tsang, Liina Tserel, Eugene Y.K. Tso, Alessandra Tucci, Şadiye Kübra Tüter Öz, Matilde Valeria Ursini, Takanori Utsumi, Pierre Vabres, Juan Valencia-Ramos, Ana Maria Van Den Rym, Isabelle Vandernoot, Valentina Velez-Santamaria, Silvia Patricia Zuniga Veliz, Mateus C. Vidigal, Sébastien Viel, Cédric Villain, Marie E. Vilaire-Meunier, Judit Villar-García, Audrey Vincent, Dimitri Van der Linden, Alla Volokha, Fanny Vuotto, Els Wauters, Alan K.L. Wu, Tak-Chiu Wu, Aysun Yahşi, Osman Yesilbas, Mehmet Yildiz, Barnaby E. Young, Ufuk Yükselmiş, Marco Zecca, Valentina Zuccaro, Jens Van Praet, Bart N. Lambrecht, Eva Van Braeckel, Cédric Bosteels, Levi Hoste, Eric Hoste, Fré Bauters, Jozefien De Clercq, Catherine Heijmans, Hans Slabbynck, Leslie Naesens, Benoit Florkin, Mary-Anne Young, Amanda Willis, Paloma Lapuente-Suanzes, Ana de Andrés-Martín, Matilda Berkell, Valerio Carelli, Alessia Fiorentino, Surbhi Malhotra, Alessandro Mattiaccio, Tommaso Pippucci, Marco Seri, Evelina Tacconelli, Michiel van Agtmael, Anne Geke Algera, Brent Appelman, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije Bomers, Peter Bonta, Lieuwe Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, David T.P. Buis, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Mirjam Dijkstra, Dave A. Dongelmans, Romein W.G. Dujardin, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Endry H.T. Lim, Niels van Mourik, Jeaninne Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Dan A.I. Pina-Fuentes, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Reijnders, Maurits C.F. J. de Rotte, Michiel Schinkel, Marcus J. Schultz, Femke A.P. Schrauwen, Alex Schuurmans, Jaap Schuurmans, Kim Sigaloff, Marleen A. Slim, Patrick Smeele, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa M. Tsonas, Pieter R. Tuinman, Marc van der Valk, Denise P. Veelo, Carolien Volleman, Heder de Vries, Lonneke A. Vught, Michèle van Vugt, Dorien Wouters, A.H. Zwinderman, Matthijs C. Brouwer, W. Joost Wiersinga, Alexander P.J. Vlaar, Miranda F. Tompkins, Camille Alba, Daniel N. Hupalo, John Rosenberger, Gauthaman Sukumar, Matthew D. Wilkerson, Xijun Zhang, Justin Lack, Andrew J. Oler, Kerry Dobbs, Ottavia M. Delmonte, Jeffrey J. Danielson, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angiò, Ilaria Beretta, Luisa Imberti, Alessandra Sottini, Virginia Quaresima, Eugenia Quiros-Roldan, Camillo Rossi, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, and Gian Luigi Marseglia

Subjects
HLA, association, asymptomatic infection, COVID-19, population stratification, Genetics, QH426-470
Abstract

Summary: Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.

Published
2024
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37. Evolution of the cyclotron mass with doping in La$_{2-x}$Sr$_x$CuO$_4$

Author

Legros, A., Post, K. W., Chauhan, Prashant, Rickel, D. G., He, Xi, Xu, Xiaotao, Shi, Xiaoyan, Bozovic, Ivan, Crooker, S. A., and Armitage, N. P.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

The recent observation of cyclotron resonance in optimally-doped La$_{2-x}$Sr$_x$CuO$_4$ using time-domain THz spectroscopy in high magnetic field has given new possibilities for the study of cuprate superconductors. One can measure the cyclotron mass in more disordered cuprates possesing short scattering times therefore expanding the study to materials and dopings in which quantum oscillations have not been observed. Here we present the measurement of the carrier mass of the hole doped cuprate La$_{2-x}$Sr$_x$CuO$_4$ across a a range of dopings spanning the slightly underdoped ($x=0.13$) to highly overdoped ($x=0.26$), near to the termination of the superconducting dome. These results reveal a systematic increase of $m_c$ with doping, up to values greater than thirteen times the bare electron mass. This is in contrast with those masses extracted from the heat capacity, which show a peak near the pseudogap critical point $p^*$ and/or Lifshitz transition. The cyclotron frequency is linear in field up to 31 T for all dopings giving no evidence for field induced Fermi surface reconstructions. The cyclotron mass is found to be positive for all dopings, but with a magnitude systematically below the heat capacity mass for under and optimally doped samples, while exceeding it for overdoped samples. Among other aspects, these results are surprising as photoemission reveals a Lifshitz transition in the middle of our doping range and the sign of the cyclotron mass determined from a finite frequency resonance is -- in conventional theories -- a {\it topological quantity} only sensitive to whether or not the Fermi surface is closed around holes or electrons. We see no sign of a divergence of the mass near $p^*$ nor near the Lifshitz transition, showing that any singularity -- if it exists -- is not strong enough to affect the cyclotron mass., Comment: 9 pages, 4 figures

Published
2022
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38. Disorder-enhanced effective masses and deviations from Matthiessen's rule in PdCoO$_2$ thin films

Author

Barbalas, David, Legros, Anaëlle, Rimal, Gaurab, Oh, Seongshik, and Armitage, N. P.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The observation of hydrodynamic transport in the metallic delafossite PdCoO$_2$ has increased interest in this family of highly conductive oxides, but experimental studies so far have mostly been confined to bulk crystals. In this work, the development of high-quality thin films of PdCoO$_2$ has enabled a thorough study of the conductivity as a function of film thickness using both dc transport and time-domain THz spectroscopy. With increasing film thickness from 12 nm to 102 nm, the residual resistivity decreases and we observe a large deviation from Matthiessen's rule (DMR) in the temperature dependence of the resistivity. We find that the complex THz conductivity is well fit by a single Drude term. We fit the data to extract the spectral weight and scattering rate simultaneously. The temperature dependence of the Drude scattering rate is found to be nearly independent of the residual resistivity and cannot be the primary mechanism for the observed DMR. Rather, we observe large changes in the spectral weight as a function of disorder, changing by a factor of 1.5 from the most disordered to least disordered films. We believe this corresponds to a mass enhancement of $\geq 2$ times the value of the bulk effective mass which increases with residual disorder. This suggests that the mechanism behind the DMR observed in dc resistivity is primarily driven by changes in the electron mass. We discuss the possible origins of this behavior including the possibility of disorder-enhanced electron-phonon scattering, which can be systematically tuned by film thickness., Comment: 10 pages, 8 figures

Published
2022
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39. Instantaneous Frequency Estimation In Multi-Component Signals Using Stochastic EM Algorithm

Author

Legros, Quentin, Fourer, Dominique, Meignen, Sylvain, and Colominas, Marcelo A.

Subjects
Electrical Engineering and Systems Science - Signal Processing, Computer Science - Machine Learning, Mathematics - Numerical Analysis
Abstract

This paper addresses the problem of estimating the modes of an observed non-stationary mixture signal in the presence of an arbitrary distributed noise. A novel Bayesian model is introduced to estimate the model parameters from the spectrogram of the observed signal, by resorting to the stochastic version of the EM algorithm to avoid the computationally expensive joint parameters estimation from the posterior distribution. The proposed method is assessed through comparative experiments with state-of-the-art methods. The obtained results validate the proposed approach by highlighting an improvement of the modes estimation performance., Comment: Submitted to GRETSI 2022

Published
2022

42. Prospective multi-center evaluation of the incidence of unplanned extubation and its outcomes in French intensive care units. The Safe-ICU study

Author

Guillemin, Jérémie, Rieu, Benjamin, Huet, Olivier, Villeret, Léonie, Pons, Stéphanie, Bignon, Anne, de Roux, Quentin, Cinotti, Raphaël, Legros, Vincent, Plantefeve, Gaëtan, Dayhot-Fizelier, Claire, Omar, Edris, Cadoz, Cyril, Bounes, Fanny, Caplin, Cécile, Toumert, Karim, Martinez, Thibault, Bouvier, Damien, Coutrot, Maxime, Godet, Thomas, Garçon, Pierre, Constantin, Jean-Michel, Assefi, Mona, and Blanchard, Florian

Published
2024
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43. Faire vivre et grandir une communauté de chefs de service : acte 2 en hématologie

Author

Houot, Roch, Calmettes, Claire, Park, Sophie, Pascal, Laurent, Peffault de Latour, Regis, Pigneux, Arnaud, Quinquenel, Anne, Raffoux, Emmanuel, Thieblemont, Catherine, Touati, Mohamed, Trebouet, Adrien, Vaida, Ioana, Wémeau, Mathieu, Bastie, Jean-Noël, Bay, Jacques-Olivier, Cluzeau, Thomas, Cornillon, Jérôme, Damaj, Ghandi, Deconinck, Eric, Feugier, Pierre, Fornecker, Luc-Matthieu, Gay, Julie, Hermine, Olivier, Hospital, Marie Anne, Hunault, Mathilde, Jaccard, Arnaud, Jardin, Fabrice, Le Calloch, Ronan, Legros, Laurence, Leleu, Xavier, Lemonnier, François, Malfuson, Jean-Valere, Morel, Pierre, Ochmann, Marlene, Orsini-Piocelle, Frédérique, and Gyan, Emmanuel

Published
2024
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50. WORKING MEMORY IN LEARNING TO WRITE: EFFECTS OF CONTEXT AND DIGITAL TOOLS’ GENERALIZED USAGE

Author

Zohra Sakrane, Karen Ferreira-Meyers, and Denis Legros

Subjects
written verbal production, models of production, activated knowledge and processes, context, digital tools., Philology. Linguistics, P1-1091, Language. Linguistic theory. Comparative grammar, P101-410
Abstract

In this article, we present the main models of written verbal production activity that allow us to analyze and describe the processes implemented during this activity. According to these models, writers activate several types of knowledge: knowledge about the domain of the world evoked by the text to be produced, knowledge about language and texts, and pragmatic knowledge. The analysis of these models makes it possible to account for and describe the knowledge activated during the realization of this text production activity, but also the different processes implemented during this complex cognitive activity. We examine the effects of the development and generalized use of digital tools on the functioning of working memory and written verbal production.

Published
2023
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