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143 results on '"Lei, Pengpeng"'

17. Near‐Infrared‐Responsive Rare Earth Nanoparticles for Optical Imaging and Wireless Phototherapy.

Author

Du, Pengye, Wei, Yi, Liang, Yuan, An, Ran, Liu, Shuyu, Lei, Pengpeng, and Zhang, Hongjie

Subjects
RARE earth metals, OPTICAL images, PHOTOTHERAPY, PHOTODYNAMIC therapy, OPTICAL communications, NANOPARTICLES
Abstract

Near‐infrared (NIR) light is well‐suited for the optical imaging and wireless phototherapy of malignant diseases because of its deep tissue penetration, low autofluorescence, weak tissue scattering, and non‐invasiveness. Rare earth nanoparticles (RENPs) are promising NIR‐responsive materials, owing to their excellent physical and chemical properties. The 4f electron subshell of lanthanides, the main group of rare earth elements, has rich energy‐level structures. This facilitates broad‐spectrum light‐to‐light conversion and the conversion of light to other forms of energy, such as thermal and chemical energies. In addition, the abundant loadable and modifiable sites on the surface offer favorable conditions for the functional expansion of RENPs. In this review, the authors systematically discuss the main processes and mechanisms underlying the response of RENPs to NIR light and summarize recent advances in their applications in optical imaging, photothermal therapy, photodynamic therapy, photoimmunotherapy, optogenetics, and light‐responsive drug release. Finally, the challenges and opportunities for the application of RENPs in optical imaging and wireless phototherapy under NIR activation are considered. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Wireless Photoactivated Targeted Nanosystem for Oncotherapy ViaSynergistic Effects of Hyperthermia/Redox Stress Amplification/GSK-3β Activity Inhibition

Author

Liang, Yuan, Lei, Pengpeng, An, Ran, Du, Pengye, Liu, Shuyu, Wei, Yi, and Zhang, Hongjie

Abstract

Highly soluble salts and gas mediated therapies are emerging antitumor strategies. However, the therapeutic efficacy remains restricted by difficulty in delivering them to the tumor site and poorly controlled release in deep tissues. Here, an intelligent wireless photoactivated targeted nanosystem is designed for delivering LiCl and H2to tumors for therapy. LiCl causes cell death by inhibiting the activity of GSK-3β. H2selectively interacts with reactive oxygen species in the tumor, leading to redox stress, which induces apoptosis. The significant heat generated by the nanosystem not only kills tumor cells but also accelerates the dissolution of LiCl and the release of H2. The rapid dissolution of LiCl leads to a surge in intracellular osmotic pressure, which further intensifies the redox stress response and enhances the efficiency of therapy. The nanosystem shows efficient tumor therapeutic capability viasynergistic effects of hyperthermia/redox stress amplification/GSK-3β activity inhibition.

Published
2024
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22. Multifunctional Superparticles for Magnetically Targeted NIR‐II Imaging and Photodynamic Therapy.

Author

Liu, Yilin, Liang, Yuan, Lei, Pengpeng, Zhang, Zhen, and Chen, Yongming

Subjects
PHOTODYNAMIC therapy, IRON oxide nanoparticles, INTRAVENOUS injections, PHOTOTHERMAL effect, NEAR infrared radiation, CANCER treatment, PHOTON upconversion, LUMINESCENCE, MAGNETIC particle imaging
Abstract

Theranostics, the combination of diagnostics and therapies, has been considered as a promising strategy for clinical cancer treatment. Nonetheless, building a smart theranostic system with multifunction for different on‐demand applications still remains elusive. Herein, an easy and user‐friendly microemulsion based method is developed to modularly assemble upconversion nanoparticles (UCNPs) and Fe3O4 nanoparticles together, forming multifunctional UCNPs/Fe3O4 superparticles with highly integrated functionalities including the 808 nm excitation for real‐time NIR‐II imaging, magnetic targeting, and the upconversion luminescence upon 980 nm excitation for on‐demand photodynamic therapy (PDT). With a magnet placed nearby the tumor, in vivo NIR‐II imaging uncovers that superparticles tend to migrate toward the tumor and exhibit intense tumor accumulation, ≈6 folds higher than that without magnetic targeting 2 h after intravenous injection. NIR laser irradiation is then used to trigger PDT, obtaining an outstanding tumor elimination under magnetic tumor targeting, which shows a high potential to be applied in targeted cancer theranostics. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Facile synthesis of rare earth-doped CeF3 two-dimensional nanosheets and their application in ratiometric luminescence temperature sensing.

Author

An, Ran, Liang, Yuan, Du, Pengye, Lei, Pengpeng, and Zhang, Hongjie

Subjects
TERBIUM, LUMINESCENCE, RARE earth ions, NANOSTRUCTURED materials, CONSTRUCTION materials, ENERGY transfer
Abstract

Discovery of new morphological and structural materials is significant but remains challenging. In this work, rare earth-doped CeF3 two-dimensional (2D) nanosheets were successfully synthesized using a facile and effective solvothermal method. By changing the amount of water in the solvent and the doping amount of rare earth ions, the morphology of CeF3 is significantly affected, but the hexagonal phase structure is always maintained. Under excitation at 254 nm, CeF3:20% Gd, 30% Tb 2D nanosheets emit bright green light, but the luminescence color changes to red when some of the Tb3+ ions are replaced by Eu3+ ions due to the efficient energy transfer from Tb3+ to Eu3+ ions. Moreover, the temperature-dependent luminescence properties of CeF3:20% Gd, 25% Tb, 5% Eu prove that it can be used as a ratiometric luminescent thermometer with an absolute sensitivity of 1.54% K−1 and a maximum relative sensitivity of 4.56% K−1 at 373 K. This study enriches the treasure trove of new materials and paves the way for future applications of CeF3-based luminescent materials in the field of temperature sensing. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Plasmonic Pt Superstructures with Boosted Near‐Infrared Absorption and Photothermal Conversion Efficiency in the Second Biowindow for Cancer Therapy

Author

Wang, Qishun, primary, Wang, Huan, additional, Yang, Yang, additional, Jin, Longhai, additional, Liu, Yang, additional, Wang, Ying, additional, Yan, Xiangyu, additional, Xu, Jing, additional, Gao, Ruoqian, additional, Lei, Pengpeng, additional, Zhu, Junjie, additional, Wang, Yinghui, additional, Song, Shuyan, additional, and Zhang, Hongjie, additional

Published
2019
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48. Enhanced upconversion luminescence and controllable phase/shape of NaYF4:Yb/Er crystals through Cu2+ ion doping.

Author

Du, Kaimin, Xu, Xia, Yao, Shuang, Lei, Pengpeng, Dong, Lile, Zhang, Manli, Feng, Jing, and Zhang, Hongjie

Subjects
LUMINESCENCE, DOPING agents (Chemistry)
Abstract

Hexagonal phase (β-) NaYF4:Yb/Er upconversion (UC) microrods doped with Cu2+ ions were prepared via a facile solvothermal method. Simultaneous phase and shape control of NaYF4:Yb/Er crystals with enhanced upconversion luminescence (UCL) was successfully realized by codoping with Cu2+ ions. With an increasing Cu2+ ion concentration in the NaYF4:Yb/Er system, the crystal structure changed from a mixture of α- and β-phases to the pure β-phase and was converted into highly uniform microrods. As for the Cu2+ ion doped β-NaYF4:Yb/Er upconversion microrods, the maximum emission occurs with the sample added with 60 mol% Cu2+ ions and the UCL intensities of the green and red emissions were enhanced 37 and 25 times, respectively. Meanwhile, the possible mechanisms for the enhanced UCL of NaYF4:Yb/Er crystals were also discussed in detail. Moreover, the temperature dependent UCL properties of 60 mol% Cu2+ ion doped β-NaYF4:Yb/Er were studied under 980 nm excitation, which were temperature-sensitive over a wide temperature range from 123 K to 423 K. The change in UCL intensity influenced by temperature was discussed in detail. [ABSTRACT FROM AUTHOR]

Published
2018
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